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    Jolito John Dleh A.

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    The document discusses research on how different amounts of mosquito bites affect the chance of getting a disease from a mosquito. The problem statement outlines how mosquitoes transfer diseases and the different diseases they can transmit. The hypothesis states that if the number of mosquito bites increases, then the chances of getting a disease will increase.

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    Jolito John Dleh A.

    Uploaded by

    .....
    35 views5 pages
    The document discusses research on how different amounts of mosquito bites affect the chance of getting a disease from a mosquito. The problem statement outlines how mosquitoes transfer diseases and the different diseases they can transmit. The hypothesis states that if the number of mosquito bites increases, then the chances of getting a disease will increase.

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    The document discusses research on how different amounts of mosquito bites affect the chance of getting a disease from a mosquito. The problem statement outlines how mosquitoes transfer diseases and the different diseases they can transmit. The hypothesis states that if the number of mosquito bites increases, then the chances of getting a disease will increase.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    35 views5 pages

    Jolito John Dleh A.

    Uploaded by

    .....
    The document discusses research on how different amounts of mosquito bites affect the chance of getting a disease from a mosquito. The problem statement outlines how mosquitoes transfer diseases and the different diseases they can transmit. The hypothesis states that if the number of mosquito bites increases, then the chances of getting a disease will increase.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 5

    Performance Task (PETA)

    Portfolio of Abstracts/Individual
    Topic
    Research 8
    Quarter 1
    Project Title:
    How different amounts of mosquito bites
    affect the chance of getting a disease
    from a mosquito

    Category:
    Animal Sciences
    Jolito, John D’leh A.
    8-Pascal

    Problem Statement
    Main Problem:
    How do different frequencies of
    mosquito bites affect the chances of
    getting a disease from a mosquito?

    Sub-problem/s:
    1. How does a mosquito transfer
    diseases?
    2. What are the different diseases
    that a mosquito can transfer?

    Hypothesis: (IF and THEN statement)


    If the number of mosquito bites
    increases, then the chances of getting a
    disease will increase.
    Differential mosquito attraction to humans is
    associated with skin-deprived carboxylic acid
    levels
    Some people are more attractive to mosquitoes than others, but the
    mechanistic basis of this phenomenon is poorly understood. We tested
    mosquito attraction to human skin odor and identified people who are
    exceptionally attractive or unattractive to mosquitoes. These differences
    were stable over several years. Chemical analysis revealed that highly
    attractive people produce significantly more carboxylic acids in their skin
    emanations. Mutant mosquitoes lacking the chemosensory co-receptors Ir8a,
    Ir25a, or Ir76b were severely impaired in attraction to human scent, but
    retained the ability to differentiate highly and weakly attractive people. The
    link between elevated carboxylic acids in “mosquito-magnet” human skin
    odor and phenotypes of genetic mutations in carboxylic acid receptors
    suggests that such compounds contribute to differential mosquito attraction.
    Understanding why some humans are more attractive than others provides
    insights into what skin odorants are most important to the mosquito and
    could inform the development of more effective repellents.

    Authors/Researchers:
    Maria Elena De Obaldia, Takeshi Morita, Laura C. Dedmon, Daniel J. Boehmler, Caroline S.
    Jiang, Emely V. Zeledon, Justin R. Cross, Leslie B. Vosshall

    Title of the Research:


    Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels

    Year of Publication:
    2022

    Converting endogenous genes of the malaria


    mosquito into simple non-autonomous gene drives
    for population replacement
    Gene drives for mosquito population replacement are promising tools for
    malaria control. However, there is currently no clear pathway for safely
    testing such tools in endemic countries. The lack of well-characterized
    promoters for infection-relevant tissues and regulatory hurdles are further
    obstacles for their design and use. Here we explore how minimal genetic
    modifications of endogenous mosquito genes can convert them directly into
    non-autonomous gene drives without disrupting their expression. We co-
    opted the native regulatory sequences of three midgut-specific loci of the
    malaria vector Anopheles gambiae to host a prototypical antimalarial
    molecule and guide-RNAs encoded within artificial introns that support
    efficient gene drive. We assess the propensity of these modifications to
    interfere with the development of Plasmodium falciparum and their effect on
    fitness. Because of their inherent simplicity and passive mode of drive such
    traits could form part of an acceptable testing pathway of gene drives for
    malaria eradication

    Authors/Researchers:
    Astrid Hoermann, Sofia Tapanelli, Paolo Capriotti, Giuseppe Del Corsano, Ellen KG Masters,
    Tibebu Habtewold, George K Christophides, Nikolai Windbichler

    Title of the Research:


    Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives
    for population replacement

    Year of Publication:
    2021

    Vertical Transmission of Zika Virus in Aedes


    aegypti Mosquitoes

    Previous experimental studies have demonstrated that a number of


    mosquito-borne flavivirus pathogens are vertically transmitted in their insect
    vectors, providing a mechanism for these arboviruses to persist during
    adverse climatic conditions or in the absence of a susceptible vertebrate host.
    In this study, designed to test whether Zika virus (ZIKV) could be vertically
    transmitted, female Aedes aegypti and Aedes albopictus were injected with
    ZIKV, and their F1 adult progeny were tested for ZIKV infection. Six of 69
    Ae. aegypti pools, comprised of a total of 1,738 F1 adults, yielded ZIKV
    upon culture, giving a minimum filial infection rate of 1:290. In contrast,
    none of 803 F1 Ae. albopictus adults (32 pools) yielded ZIKV. The MFIR
    for Ae. aegypti was comparable to MFIRs reported for other flaviviruses in
    mosquitoes, including dengue, Japanese encephalitis, yellow fever, West
    Nile, and St. Louis encephalitis viruses. The results suggest that vertical
    transmission may provide a potential mechanism for the virus to survive
    during adverse conditions.

    Authors/Researchers:
    S. Thangamani, J. Huang, C. E. Hart, H. Guzman, R. B. Tesh

    Title of the Research:


    Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes

    Year of Publication:
    2016

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