Empty Nest Assignment v.2021-22

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Empty Nest Assignment

Learning Objectives

1. Identify the diagnostic criteria and clinical presentation for various mood disorders.
2. Articulate the key principles of treatment for major depression including psychotherapeutic,
pharmacological, and other somatic treatments.
3. Understand and apply to clinical practice the risk factors associated with suicide and
suicidal behavior.

Mrs. Baker is a 49-year-old female who has been married for 28 years. She has three grown
children. The two older ones are married and have left home. The youngest one, Becky, is a
sophomore in college. Now it's only her and her husband at home.

After Becky left, Mrs. Baker was doing fairly well, although she freely admits she was missing
her kids and felt “at loose ends.” A few months later, however, she developed insomnia, loss of
energy, loss of interest in things, and started to cry frequently. She could not quit worrying about
Becky, and she kept rehearsing all kinds of bad scenarios in her mind about what might happen
to her daughter. She started to call her daughter several times a day for reassurance, but it did not
help. She had no appetite and lost quite a bit of weight. She felt tired all the time and started to
feel hopeless and worthless. She even had some suicidal thoughts, which really scared her. This
went on for about four months. She thought she might "snap out of this," but her condition just
did not improve. This was doubly frightening to her because her mother had several bouts with
severe depression, including two failed suicide attempts, which necessitated psychiatric
hospitalizations. "I don't want to go down that same road!" She also worried that she may be
medically ill. She underwent a complete physical, including blood work, which showed no
significant medical problems, other than the beginning of menopause. Her primary care
physician put her on an SSRI. This seemed to help. Mrs. Baker's appetite returned, ("now it's
almost too good! I'm gaining too much weight!"), she is sleeping through the night, she has more
energy, and her obsessive worrying has ceased. The only major concern today is that Mrs. Baker
has absolutely no sexual interest or desire. "If this does not improve, doctor, I'm afraid for my
marriage."

QUESTIONS:
1. What is on her differential and what is her most likely diagnosis?

MDD
Adjustment Disorder
GAD
Bipolar Disorder
2. What would you have to be on the lookout for as far as her medical status? Which medical
problems might mimic depression?

Hypothyroidism
Dementia

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Adrenal insufficiency
Cushing syndrome
Vitamin D/B12 deficiency
MS
Hep C, HIV
Menopause

3. What factors would help you determine the appropriate setting for treatment: Outpatient,
inpatient, or day treatment?

Social support (obtain collateral)


Degree of impairment
Suicidality
Admit if patient refuses to eat, has unkempt appearance, displays SI/HI, or psychosis

4. What factors should be considered when you select an antidepressant?

Side effect profile


Dosage and routes of administration
Hx and FHx of mental health disorders and treatments that have worked
Interactions with other medications
Cost and accessibility

5. How long would you treat with it and how do you decide? What are the phases of treatment?

Acute (6 – 12 weeks)
Continuation (4 – 9 months)
Maintenance (1 year out)
For beyond a year, look at past number of depressive episodes in the past, hx of suicide, and
residual symptoms, stressors and psychosocial environment

6. At what point would you change the medication? Augment with another medication? What are
your options for each?

Change if side effects interfere with daily functioning.


Can either replace or augment with bupropion if there are sexual side effects
Augment with aripiprazole
Augment with psychotherapy
Lithium and clozapine (if chronic SI – to decrease suicidality)
If comorbid hypothyroidism, supplement with levothyroxine
If comorbid anxiety, buspirone or propranolol

7. What about the role of psychotherapy in depression? Is there evidence that psychotherapy
improves mood? What types of psychotherapy have been shown to be beneficial?

Psychotherapy is an adjunct (not monotherapy) for depression that has been shown to improve

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mood.
CBT: Breaking the negative cycle between thoughts, feelings, and behaviors
Interpersonal therapy: Helping the patient with their relationships with others
Behavioral therapy

8. Is there a role for ECT or other somatic treatments in this case? When would it be considered?
What are the contraindications? Side effects? Typical course of treatment?

Not eligible because has not yet failed 2 antidepressant trials

Indications:
Catatonic schizophrenia
Elderly patients with polypharmacy
Depression with psychotic features
Pregnancy

Contra-indications:
No absolute CIs.
Relative – recent cardiovascular event; elevated ICP (look for papilledema)

Side effects:
Retrograde and anterograde amnesia
Headaches

Course:
2-3x weekly for a total of 6 – 12 sessions.

ABBREVIATIONS:
MDD = major depressive disorder
CVA = cerebral-vascular accident
ECT = electroconvulsive therapy
VNS = vagal nerve stimulations
TMS = transcranial magnetic stimulation
CBT = cognitive behavioral therapy
IPT = interpersonal therapy
MAOI = monoamine oxidase inhibitors
SSRI = selective serotonin reuptake inhibitors

REFERENCES:
1. American Psychiatric Association: Practice guideline for the treatment of patients with major
depressive disorder, 3rd edition in Supplement to the American Journal of Psychiatry, Vol 167
(10), October 2010.
2. Preskorn S.H. , Treatment Options for the Patient who does not respond well to initial
antidepressant therapy, J of Psychiatric Practice Vol 15 (3), 202-210, May 2009.
3. MCG- GHSU Psychiatry Clerkship Survival guide, 2011.

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PLEASE REFER TO THE CLERKSHIP SURVIVAL GUIDE OR ANY TEXTBOOK
MNETIONED IN THE
RECOMMENDED READOING LIST FOR A DESCRIPTION OF MEDICATION CLASSES
MENTIONED
IN THIS DISCUSSION.

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