Multisystem Problems - NCM 410 LEC 1
Multisystem Problems - NCM 410 LEC 1
Multisystem Problems - NCM 410 LEC 1
PROBLEMS
NCM 410 LECTURE
Table of contents
01 02 03
SYSTEMIC MULTI-ORGAN
INFLAMMATORY DYSFUNCTION
SHOCK RESPONSES SYNDROME(MODS)
SYNDROME(SIRS)
The person experiencing shock
01
SHOCK
Shock is a clinical syndrome characterised by a systemic imbalance between
oxygen supply and demand. This imbalance results in a state of inadequate
blood flow to body organs and tissues, causing life-threatening cellular
dysfunction. (Pearson, 2017)
Overview of cellular homeostasis and
haemodynamics
FOUR PHYSIOLOGIC COMPONENTS:
CO = SV × HR
baSIC HEMODYNAMICS
■ Mean arterial pressure (MAP) is the product of cardiac
output and systemic vascular resistance (SVR):
MAP = CO × SVR
MAP normal range = 70 to 110
■Sympathetic tone.
Increased sympathetic stimulation increases
vasoconstriction and SVR; decreased sympathetic
stimulation allows vasodilation which decreases SVR.
pathophysiology
Altered Hemodynamics
SHOCK
● CARDIOGENIC shock
● Hypovolemic shock
● distributive/vasogenic
● Anaphylactic shock
● Neurogenic shock
● Septic shock
● Obstructive shock
assessment
SHOCK MANIFESTATIONS
Cardiogenic SHOCK
Cardiogenic shock manifestations
hypovolemic SHOCK
is caused by a decrease in intravascular
volume of 15% or more (Huether & McCance,
2013)
Hvs manifestations
1. INITIAL STAGE
2. COMPENSATORY
3. PRORESSIVE STAGES
4. IRREVERSIBLE/refractory STAGE
Distributive/
vasogenic shock
anaphylactic SHOCK
neurogenic SHOCK
Neurogenic shock is the result of an
imbalance between parasympathetic and
sympathetic stimulation of vascular smooth
muscle.
neurogenic
shock
05
septic SHOCK
Septic shock, the leading cause of death for
people in critical care units, is one part of a
progressive syndrome called systemic
inflammatory response syndrome (SIRS).
Septic
shock
● Toxic Shock syndrome
● Disseminated intravascular coagulation
(DIC)
06
obstructive SHOCK
is caused by an obstruction in the heart or
great vessels that either impedes venous
return or prevents effective cardiac pumping
action.
obstructive
shock
● Jugular vein distension
● Pulsus paradoxus
Diagnostic studies
● Hx and PE
● labs ● 12 leads ecg
● Continuous ecg
monitoring
● Chest x-ray, mri, ct scan
● Cont. pulse oximetry
● Invasive and
non=invasive
hemodynamic monitoring
shock Interprofessional care
cardiovascular endocrine
Gi system hematologic
● GI bleeding, mucous ● Bleeding times, PT, PTT
ischemia ● Platelet count
Sequential organ failure assessment
(sofa)
shock Sirs
early sign of shock is
Characterized by
a change in the level
generalized
of consciousness, with
inflammation in
restlessness being a
organs remote from
common symptom of
the initial insult
cerebral hypoxia.
types Mods
Cardiogenic the failure of 2 or
Hypovolemic more organ systems
Anaphylactic in an acutely ill patient
Neurogenic
Septic
Obstructive
“
“I attribute my success to this, I never gave nor took
any excuse.”
—florence nightingale
“I attribute my success to this, I
never gave nor took any excuse.”
—florence nightingale
Thanks!
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