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    Hematology Review Notes

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    Tan CA
    The document discusses hematopoiesis, which is the production of blood cells and plasma through stages within the bone marrow, liver, and spleen. It describes the three stages of hematopoiesis as the mesoblastic, hepatic, and medullary periods. Finally, it outlines the six steps of red blood cell maturation from pronormoblast to erythrocyte.

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    Hematology Review Notes

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    Tan CA
    34 views2 pages
    The document discusses hematopoiesis, which is the production of blood cells and plasma through stages within the bone marrow, liver, and spleen. It describes the three stages of hematopoiesis as the mesoblastic, hepatic, and medullary periods. Finally, it outlines the six steps of red blood cell maturation from pronormoblast to erythrocyte.

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    HEMATOLOGY REVIEW NOTES

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    The document discusses hematopoiesis, which is the production of blood cells and plasma through stages within the bone marrow, liver, and spleen. It describes the three stages of hematopoiesis as the mesoblastic, hepatic, and medullary periods. Finally, it outlines the six steps of red blood cell maturation from pronormoblast to erythrocyte.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    34 views2 pages

    Hematology Review Notes

    Uploaded by

    Tan CA
    The document discusses hematopoiesis, which is the production of blood cells and plasma through stages within the bone marrow, liver, and spleen. It describes the three stages of hematopoiesis as the mesoblastic, hepatic, and medullary periods. Finally, it outlines the six steps of red blood cell maturation from pronormoblast to erythrocyte.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 2

    HEMATOLOGY REVIEW NOTES

    I. Hematopoiesis
    - is the production of all of the cellular components of blood and blood
    plasma. It occurs within the hematopoietic system, which includes organs and
    tissues such as the bone marrow, liver, and spleen. Simply, hematopoiesis is the
    process through which the body manufactures blood cells.

    STAGES OF HEMATOPOIESIS
    1. MESOBLASTIC PERIOD
     Start 19th or 20th day of Gestation.
     Production of Erythroblast
     Presence of Embryonic Hemoglobins
    2. HEPATIC PERIOD
     4th or 5th week of gestation.
     DEFINITIVE HEMATOPOIESIS
     Liver still produces even after 1-2 weeks after birth
    3. MEDULLARY PERIOD
     Fifth month of Gestation
     3 weeks after birth
     Bone marrow is the only hematopoietic organ remaining.

    Multipotent Progenitor Take Note:


    Hematopoietic Stem cell RBC MATURATION 18-21 days
    Growth Factors:
     RBC (GM-CSF, IL3,EPO)
     WBC (GM-CSF, IL3, IL5)
    Common Myeloid Common Lympoid  Platelets (GM-CSF, IL3,6,11 TPO)
    Progenitor Cells Progenitor Cells  NK CELLS (IL 1,2,4,5,6,7,,12,14,15)

    Granulocytes, B Cells
    Monocytes
    T Cells
    Red blood cells
    Platelets
    NK Cells
    RED BLOOD CELL MATURATION

    1. PRONORMOBLAST/RUBRIBLAST
     Globin production begins
    2. BASOPHILIC NORMOBLAST/PRORUBRICYTE
     Hemoglobin production begins
    3. POLYCHROMATIC NORMOBLAST/RUBRICYTE
     Hemoglobin synthesis is evident/ Last Stage to undergo mitosis.
    4. ORTHOCHRMATIC NORMOBLAST/METARUBRICYTE
     The nucleus is ejected together with the mitochondria (PYKNOTIC NUCLEUS)
    5. POLYCHHROMATIC ERYTHROCYTE/RETICULOCYTES
     First stage without nucleus
     1 day in the circulation before it matures
     Ribosomal RNA Remnants
    6. ERYTHROCYTE

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