BP 401T MCQ Unit2 by Dr. Parjanya Shukla

27 Important MCQs
(Unit-2)
(With Solutions)
Pharmaceutical Organic Chemistry-

III
BP 401T
By
Dr. Parjanya Kumar Shukla
Assoc. Prof. & HOD
Krishnarpit Institute of Pharmacy
Prayagraj, India
Q.1. Isomerism that arises out of the difference in
spatial arrangement of atoms or groups about the
doubly bonded carbon atoms are called? (In
specific)
a) Structural Isomerism
b) Stereo Isomerism
c) Geometrical Isomerism
d) Optical Isomerism
Answer: c) Geometrical Isomerism

Q.2. Which among the following does not exhibit
geometric isomerism?
a) 3-hexene
b) 2-hexene
c) 1-hexene
d) 4-hexene
Answer: c) 1-hexene
Explanation: Alkenes like 1-hexene when flipped from top to bottom
they have identical structures and also they have C=CH 2unit which
does not exist as cis-trans isomers.
Q.3. Select the incorrect option from the following.
a) Fischer projections are two dimensional representations of

three dimensional molecules
b) A molecule is achiral if it cannot be superimposed on its mirror
reflection
c) E and Z notations are based on Cahn, Ingold and Prelog priority
system
d) Chiral molecules which are non-superimposable mirror images
of each other are enantiomers
Answer: b) A molecule is achiral if it cannot be

superimposed on its mirror reflection
Q.4. The relationship of the following two
structures is
a) structural isomers H3C Br Br Br

b) geometric isomers C C C C
Br CH3 H3C CH3
c) not isomeric
d) conformational isomers
Answer: b) geometric isomers

Q.5. Which of the following notations is not used
to distinguish between pairs of enantiomers?
a) R and S
b) E and Z
c) + and -
d) D and L
Answer: b) E and Z
Q.6. Cis-trans isomerism only occurs in compounds
possessing double bonds
a) True
b) False
c) yes for geometrical isomerism double bond is
must
d) cant say about this
Answer: b) False
Explanation : While cis-trans isomerism is widely associated with

compounds exhibiting double bonds, it also arises in cyclic
compounds, where the groups attached to the ring lie above or below
the plane of the ring.
Q.7. The cis-trans nomenclature is not applicable when
a) The different groups attached to the carbon atom of double bond are
same
b) At least one of the group attached to each carbon atom is same
c) The cis-trans nomenclature is applicable for all compounds
d) The different groups attached to the carbon atom of double bond are
not same
Answer: d
Explanation: The cis-trans nomenclature is applicable when the

different groups attached to the carbon atom of double bond are
same or atleast one of the group attached to each carbon atom is
same.
Q.8. Assign E or Z configuration to the given compound
a) Z-configuration
b) E-configuration
c) S-configuration
d) R-configuration
Answer: b) E-configuration
Q.9. The reaction that yields predominantly one enantiomer of a
possible pair is called
a) Dynamicselective
b) Stereoselective
c) Regioselective
d) Stereospecific
Answer: b) Stereoselective
Explanation: Stereoselectivity is the property of a chemical reaction in

which a single reactant forms an unequal mixture of stereo isomers
during the non-stereo specific creation of a new stereo center
Q.10. The reaction in which stereochemically different molecules
react differently is called
a) Dynamicselective
b) Stereoselective
c) Regioselective
d) Stereospecific
Answer d) Stereospecific
Explanation: Stereospecificity is the property of a reaction mechanism

that leads to different stereo isomeric reaction products from different
stereo isomeric reactants, or which operates on only one of the stereo
isomers.
Q.11. Syn and anti notations are used to represent
geometrical isomerism in …. And due to……..?
a) Alkenes / C=C
b) Alkanes / C-C
c) Oximes / N=N
d) Oximes / C=N
Answer: d) Oximes / C=N
Explanation: the syn form is the one in which both the lowest group
on carbon and the hydroxyl (-OH) group on nitrogen are on the
same side of the C=N.
Whereas in the anti form, they are on the opposite side
Q.12. in following example of oxime which is syn and which is
anti cofiguration
a) A- anti / B- syn
b) A- syn / B- anti
c) No syn only anti
d) No anti only syn
Answer: b) A- syn / B- anti

Q.13. R,S System and E,Z system is based on Sequence rules
these rules are also known as
a) CIP Rules
b) Group priority rules
c) Cahn Ingold Prelog system
d) All of the above
Answer: d) All of the above

Q.14. Which of the following groups has the second highest
priority in the Cahn-Ingold-Prelog sequence rules?
a) CH2OH
b) CH2OCH3
c) CH=O
d) CO2H
Answer: d) CO2H
Q.15. Isomerism in ortho substituted biphenyl is known as
Atropisomerism, aries due to which condition?
a) A rotationally stable axis

b) Presence of different substituents on both sides of the axis
c) bulky groups at ortho positions restrict rotation
d) All of the above
Answer: d) All of the above

Q.16. what are the methods of determinataion of geometrical
isomers
a) Physical methods like m.p., b.p., solubility, dipole moment

b) Chemical methods like cyclization, chemical correlation,
stereoselective reactions
c) Both a and b
d) None of the above
Answer: c) Both a and b

Q.17. what is true about cis and trans isomers
a) In general trans isomers has higher b.p. and lower m.p. than
corresponding cis isomers
b) In general trans isomers has higher m.p. and lower b.p. than
corresponding cis isomers
c) no effect of b.p. and m.p.
d) all of the above
Answer: b) In general trans isomers has higher

m.p. and lower b.p. than corresponding cis
isomers
Q.18. Why is the boiling point of cis isomers higher?
a) Due to low dipole moment

b) Due to high dipole moment
c) Due to chiral carbon atom
d) Due to double bon between C=N
Answer: b) Due to high dipole moment

Q.19. When oxidation of benzene or quinone done in
V2O5 and followed by hydrolysis product obtained is
always in ?
a) Fumaric acid (trans configuration)

b) Racemic mixture
c) Maleic acid (cis configuration)
d) No oxidation occures
Answer: (c) Maleic acid (cis configuration)

Q.20. In cyclization reaction of maleic acid and fumaric acid
which statement is correct?
a) Only maleic acid will under go cyclization

b) Only fumaric acid will under go cyclization
c) Both will go cyclization by fumaric acid need higher
temprature
d) No will form cyclic product
Answer: c) Both will go cyclization by fumaric

acid need higher temprature
Q.21. What is syn addition?
a) When both atoms are added to the same side of the

molecule
b) When the two atoms are added to opposite sides of the
molecule
c) When more than one type of product is produced
d) When only one product type is produced
Answer: a) When both atoms are added to

the same side of the molecule
Q.22. What type of stereochemistry will be seen when H2 is
added to an alkene?
a) Stereospecifically Syn
b) Stereospecifically Anti
c) Syn and Anti
d) No stereochemistry
Answer: b) Stereospecifically Anti

Q.23. Conformations are different arrangements of atoms that
can be converted into one another by rotation about
a) Covalent bond
b) Double bond
c) Single bond
d) Triple bond
Answer: c) Single bond
Explanation: Conformational isomerism is a form of stereoisomerism

in which the isomers can be interconverted exclusively by
rotations about formally single bonds.
Q.24. Which of the following is a representation of the gauche
conformer of n- butane
Answer: b)
Q.25. The potential energy of n-butane is minimum and
maximum for (respectively)
a) Skew conformations / Eclipsed conformations

b) Staggered conformations / Eclipsed conformations
c) Eclipsed conformations/ Staggered conformations
d) Gauche/ Staggered conformations
Answer: b) Staggered conformations / Eclipsed

conformations
Explanation: The potential energy of n-butane is minimum for staggered

conformations. It is because of no steric hindrance.
The potential energy of n-butane is maximum for eclipsed

conformations. It is because of overlapping of functional groups.
Q.26. Which of the following is least stable?
a) Anti conformation
b) Gauche conformation
c) Staggered conformation
d) Eclipsed conformation
Answer: d) Eclipsed conformation
Explanation: Eclipsed conformation is the least stable due to its high

torsional energy. The potential energy of n-butane is maximum for
eclipsed conformations.
Q.27. Which of the following statements regarding chair
cyclohexane is wrong?
a) The dihedral angle of the two axial bonds on adjacent carbons is 180°.
b) The dihedral angle of the two equatorial bonds on adjacent carbons is
60°.
c) The dihedral angle between the axial bond and the equatorial bond on
adjacent carbons is 120°.
d) The axial hydrogen atoms on C1, C3, and C5 form an equilateral
triangle
Answer: c)
Explanation: The dihedral angle between the axial bond and the
equatorial bond on adjacent carbons is 60°.
Thank You !!
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27 Important MCQs

Pharmaceutical Organic Chemistry-

Answer: c) Geometrical Isomerism

a) Fischer projections are two dimensional representations of

Answer: b) A molecule is achiral if it cannot be

a) structural isomers H3C Br Br Br

Answer: b) geometric isomers

Explanation : While cis-trans isomerism is widely associated with

Explanation: The cis-trans nomenclature is applicable when the

Explanation: Stereoselectivity is the property of a chemical reaction in

Explanation: Stereospecificity is the property of a reaction mechanism

Answer: d) Oximes / C=N

Answer: b) A- syn / B- anti

Answer: d) All of the above

a) A rotationally stable axis

Answer: d) All of the above

a) Physical methods like m.p., b.p., solubility, dipole moment

Answer: c) Both a and b

Answer: b) In general trans isomers has higher

a) Due to low dipole moment

Answer: b) Due to high dipole moment

a) Fumaric acid (trans configuration)

Answer: (c) Maleic acid (cis configuration)

a) Only maleic acid will under go cyclization

Answer: c) Both will go cyclization by fumaric

a) When both atoms are added to the same side of the

Answer: a) When both atoms are added to

Answer: b) Stereospecifically Anti

Answer: c) Single bond

Explanation: Conformational isomerism is a form of stereoisomerism

a) Skew conformations / Eclipsed conformations

Answer: b) Staggered conformations / Eclipsed

Explanation: The potential energy of n-butane is minimum for staggered

The potential energy of n-butane is maximum for eclipsed

Answer: d) Eclipsed conformation

Explanation: Eclipsed conformation is the least stable due to its high

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