Chapter 9 The Endocrine System
Chapter 9 The Endocrine System
Chapter 9 The Endocrine System
The Endocrine
System
Lecture Presentation by
Patty Bostwick-Taylor
Florence-Darlington Technical College
Hormone Action
Hormone Action
Hormone Action
Hormone Action
DNA
mRNA
5
New
protein
Plasma
membrane
of target
cell 6
▪ Second-messenger system
1. Hormone (first messenger) binds to a membrane
receptor
2. Activated receptor sets off a series of reactions that
activates an enzyme
3. Enzyme catalyzes a reaction that produces a second-
messenger molecule (such as cyclic AMP, known as
cAMP)
4. Oversees additional intracellular changes to promote
a specific response in the target cell
Cytoplasm
Hormone (first
messenger)
Enzyme
ATP
1 2 3
Second
cAMP
messenger
4
Receptor
protein
Effect on cellular function,
such as glycogen
Plasma breakdown
membrane
of target cell
Cytoplasm
Hormone (first
messenger)
Enzyme
ATP
1 2 3
Second
cAMP
messenger
4
Receptor
protein
Effect on cellular function,
such as glycogen
Plasma breakdown
membrane
of target cell
Stimuli for Control of Hormone Release
Stimuli for Control of Hormone Release
▪ Hormonal stimuli
▪ Most common category of
stimulus
▪ Endocrine organs are
activated by other
hormones
▪ Example:
▪ Hormones of the
hypothalamus stimulate
the anterior pituitary to
secrete its hormones
Stimuli for Control of Hormone Release
▪ Humoral stimuli
▪ Changing blood levels of certain
ions and nutrients stimulate
hormone release
▪ Humoral indicates various body
fluids, such as blood and bile
▪ Examples:
▪ Parathyroid hormone and
calcitonin are produced in
response to changing levels of
blood calcium levels
▪ Insulin is produced in response
to changing levels of blood
glucose levels
Stimuli for Control of Hormone
Release
▪ Neural stimuli
▪ Nerve fibers stimulate
hormone release
▪ Most are under the control
of the sympathetic nervous
system
▪ Examples:
▪ Sympathetic stimulation of
the adrenal medulla to
release epinephrine and
norepinephrine
▪ Hypothalamus
▪ Pituitary gland
▪ Pineal gland
▪ Thyroid gland
▪ Parathyroid glands
▪ Thymus
▪ Adrenal glands
▪ Pancreas
▪ Gonads (testes and ovaries)
The Major Endocrine Organs
▪ Pituitary gland
▪ Pea-sized gland that hangs by a stalk from the
hypothalamus in the brain
▪ Protected by the sella turcica of the sphenoid bone
▪ Has two functional lobes
▪ Anterior pituitary—glandular tissue
▪ Posterior pituitary—nervous tissue
▪ Often called the “master endocrine gland”
Figure 9.4 Hormones released by the posterior pituitary and their target organs.
Hypothalamic
neurosecretory
Optic cells
chiasma Hypothalamus
Axon
Arterial blood supply
terminals
Posterior lobe
Capillary bed
Venous drainage
Anterior lobe
of the pituitary
ADH Oxytocin
Testes or ovaries
Anterior Pituitary
Hormone Function
Growth Hormone • Stimulates bone growth and tissue
• Causes amino acids to be built into
proteins
• Causes fats to be broken down for a
source of energy
Prolactin Stimulates milk production in females
Gonadotropic hormones Control sexual function and
(1) Luteinizing hormone (LH) production of sex steroids, estrogen
(2) Follicle-stimulating hormone and progesterone
Thyroid-stimulating hormone Influences growth and activity of
(thyrotropic hormone) the thyroid gland
Adrenocorticotropic hormone Regulates endocrine activity of the
adrenal cortex
Axon
Arterial blood supply
terminals
Posterior lobe
Capillary bed
Venous drainage
Anterior lobe
of the pituitary
ADH Oxytocin
Pineal Gland
Thyroid Gland
Thyroid Gland
Hormone Function
Thyroid hormone • Major metabolic hormone
• Controls rate of oxidation of glucose to supply
body heat and chemical energy
• Needed for tissue growth and development
• Composed of two active iodine-containing
hormones
Thyroxine (T4)—secreted by thyroid follicle
Triiodothyronine (T3)—conversion of T4 at
target tissues
Calcitonin • Decreases blood calcium levels by causing calcium
deposition on bone
• Antagonistic to parathyroid hormone
• Produced by parafollicular cells found between
the follicles
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•Goiters
•Thyroid gland enlarges due to
lack of iodine
•Salt is iodized to prevent
goiters
•Cretinism
•Caused by hyposecretion of
thyroxine
•Results in dwarfism during
childhood
•Myxedema
•Caused by hypothyroidism in adults
•Results in physical and mental
sluggishness
•Graves’ disease
•Caused by hyperthyroidism
•Results in increased metabolism, heat
intolerance, rapid heartbeat, weight loss,
and exophthalmos
Figure 9.7 Hormonal control of the level of calcium ions in the blood.
Calcitonin
Calcitonin
stimulates
calcium salt
deposit in bone.
Thyroid gland
releases calcitonin.
Stimulus
Rising blood IMB
AL
Ca2+ levels AN
CE
Calcium homeostasis of blood:
BALANCE BALANCE
9–11 mg/100 ml
IMB Stimulus
AL Falling blood
AN
CE Ca2+ levels
Thyroid
gland
Osteoclasts
degrade bone Parathyroid
matrix and release glands Parathyroid
Ca2+ into blood. glands release
parathyroid
hormone (PTH).
PTH
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Thymus
Adrenal Glands
Adrenal
Capsule
gland
Mineralocorticoid-
Kidney secreting area
Glucocorticoid-
secreting area
Adrenal
Cortex
Adrenal gland
•Medulla cortex
•Cortex
Sex hormone-
Kidney secreting area
Medulla
Adrenal
medulla
Adrenal Glands
Adrenal Glands
Figure 9.9 Major mechanisms controlling aldosterone release from the adrenal cortex.
Decreased Na+ or
increased K+ in Stress
blood
Hypothalamus
Decreased Corticotropin-
blood volume releasing
and/or blood hormone
pressure Anterior pituitary
Increased
ACTH blood pressure
Kidney or blood volume
Renin
Heart
Indirect
stimulating
effect via
angiotensin Atrial natriuretic
peptide (ANP)
Angiotensin II
Direct
stimulating Inhibitory
effect effect
Mineralocorticoid-
producing part of
adrenal cortex
Enhanced secretion
of aldosterone targets
kidney tubules
Adrenal Glands
Adrenal Glands
Adrenal Glands
▪ Adrenal medulla
▪ Produces two similar hormones (catecholamines)
1. Epinephrine (adrenaline)
2. Norepinephrine (noradrenaline)
▪ These hormones prepare the body to deal with short-
term stress (“fight or flight”) by:
▪ Increasing heart rate, blood pressure, blood glucose
levels
▪ Dilating small passageways of lungs
Adrenal
Capsule
gland
Mineralocorticoid-
Kidney secreting area
Glucocorticoid-
secreting area
Adrenal
Cortex
Adrenal gland
•Medulla cortex
•Cortex
Sex hormone-
Kidney secreting area
Medulla
Adrenal
medulla
Figure 9.10 Roles of the hypothalamus, adrenal medulla, and adrenal cortex in the stress response.
ACTH
Adrenal
Preganglionic cortex
Adrenal sympathetic
medulla fibers
Mineralocorticoids Glucocorticoids
Pancreatic Islets
▪ Pancreas
▪ Located in the abdomen,
close to stomach
▪ Mixed gland, with both endocrine and exocrine
functions
▪ The pancreatic islets (islets of Langerhans)
produce hormones
▪ Insulin—produced by beta cells
▪ Glucagon—produced by alpha cells
▪ These hormones are antagonists that maintain blood
sugar homeostasis
Pancreatic Islets
▪ Insulin
▪ Released when blood glucose levels are high
▪ Increases the rate of glucose uptake and metabolism
by body cells
▪ Effects are hypoglycemic
▪ Glucagon
▪ Released when blood glucose levels are low
▪ Stimulates the liver to release glucose to blood, thus
increasing blood glucose levels
Figure 9.12 Regulation of the blood glucose level by a negative feedback mechanism involving pancreatic hormones.
Uptake of glucose
from blood is
enhanced in most
body cells.
Glucagon-releasing
Glucose Glycogen cells of pancreas
Liver breaks
activated; release
down glycogen glucagon into blood.
stores and Liver
Glucagon
releases glucose
to the blood.
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Gonads
▪ Produce sex cells
▪ Produce sex hormones
▪ Ovaries
▪ Female gonads located in the pelvic cavity
▪ Produce eggs
▪ Produce two groups of steroid hormones
1. Estrogens
2. Progesterone
▪ Testes
▪ Male gonads suspended outside the pelvic cavity
▪ Produce sperm
▪ Produce androgens, such as testosterone
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Gonads
▪ Estrogens
▪ Stimulate the development of secondary female
characteristics
▪ Mature the female reproductive organs
▪ Progesterone
▪ Acts with estrogen to bring about the menstrual cycle
▪ Helps in the implantation of an embryo in the uterus
▪ Helps prepare breasts for lactation
Gonads
▪ Testes
▪ Produce several androgens
▪ Testosterone is the most important androgen
▪ Responsible for adult male secondary sex characteristics
▪ Promotes growth and maturation of male reproductive
system
▪ Required for sperm cell production
Other Hormone-Producing Tissues and Organs
▪ Placenta
▪ Produces hormones that maintain pregnancy
▪ Some hormones play a part in the delivery of the baby
▪ Produces human chorionic gonadotropin (hCG) in
addition to estrogen, progesterone, and other
hormones
▪ Human placental lactogen (hPL) prepares the breasts
for lactation
▪ Relaxin relaxes pelvic ligaments and pubic symphysis
for childbirth
Table 9.2 Hormones Produced by Organs Other Than the Major Endocrine Organs (1 of 3).
Developmental Aspects of the Endocrine System