047 Pathology MCQ ACEM Primary Neoplasia

NEOPLASMS
1. Which of the following is NOT a sign of anaplasia?

A. cytoplasmic & nuclear pleomorphism
B. large nucleoli & hyperchromic chromatin
C. presence of mitotic figures
D. disturbed orientation of cells
E. increased nuclear & cytoplasmic ratio
2. Malignant tumors has the following characteristics:

A. All malignant tumors are poorly differentiated
B. All malignant tumors metastasize
C. Anaplasia is a consequence of de-differentiation
D. Malignant tumors may develop capsules
E. Malignant tumors are always more rapidly proliferative than benign tumors
3. Dysplastic tissue:
A. has architectural anarchy
B. has nuclear & cytoplasmic pleomorphism
C. has more mitotic figures than are normally present
D. dysplastic changes may be reversible
E. all of the above are true
4. Which of the following skin tumor does NOT metastasize?

A. Squamous cell carcinoma
B. Basal cell carcinoma
C. Melanoma
D. All of the above can metastasize
E. None of the above metastasize
5. Normal nuclear: cytoplasmic ratio is:

A. 1: 1
B. 1:2
C. 1:3
D. 1:4
E. none of the above
6. Which of the following tumors does NOT cause lytic lesions in the vertebrae?
A. prostatic carcinoma
B. renal cell carcinoma
C. colonic carcinoma
D. bronchogenic carcinoma
E. malignant melanoma
PATHOLOGY NEOPLASM - MCQ

7. Which of the following tumor do NOT metastasize to bone?
A. breast carcinoma
B. prostatic carcinoma
c. glioma
D. bronchogenic carcinoma
E. renal cell carcinoma
8. Which of the following statements regarding tumorigenesis is TRUE?

A. All malignant tumors are monoclonal.
B. Mutant alleles of proto-oncogenes can incur cell transformation even in presence of
their normal counter parts (ie. It is a dominant phenomenon)
C. Both mutant alleles of anti-oncogenes must exist for cell transformation to occur (ie.
It is a recessive phenomenon)
D. Phenotypic attributes of a tumor is acquired in a stepwise fashion
E. All of the above
9. Which of the following statement is FALSE?

A. Oncoproteins targets the normal cellular proliferation pathway to induce tumor
progression
B. 30% of all human tumor contain the ras oncoprotein
C. Oncoprotein production is not dependent on the availability of growth factors
D. Proto-oncogenes are regulatory segments in the DNA for c-oncogenes
E. No single oncogene can fully transform cells on its own
10. Maximum size of tumor compatible with life has:

A. 106 cells
B. 109 cells
C. 1012 cells
D. 1015 cells
E. 1018 cells
1 1. Neoplastic growth has the following characteristics:

A. All cells in a tumor is in actively replicating phase of the cell cycle as there is a loss
of proliferative control.
B. Tumors with small growth fraction is refractive to chemotherapy
C. Tumor growth is associated with shortened cell cycle
D. Frequency of mitoses in a neoplasm is not reflective of its growth rate
E. All of the above are correct.
PATHOLOGY - NEOPLASM - MCQ 2

12. In tumor invasion & dissemination:
A. Extracellular matrix cleavage products are growth promoting & chemotactic for
tumor cells.
B. Tumor invasion through the extracellular matrix is by progressive expansile growth
C. Tumor cells downregulates their adhesion molecules to reduce adhesion to each other
during vascular dissemination
D. Organ selective homing of tumor cells are purely due to the anatomical location of the
primary tumor.
E. All of the above
13. Cushing's syndrome may occur as a paraneoplastic syndrome in:

A. SCC lung
B. Small cell carcinoma of lung
C. Large cell carcinoma of lung
D. Mesothelioma
E. All of the above
14. PTHrP is commonly expressed by:

A. SCC lung
B. Renal cell carcinoma
C. Ovarian carcinoma
D. Adult T cell lymphoma
E. All of the above
15. Which of the following is NOT a paraneoplastic syndrome in bronchogenic

carcinoma?
A. Horner's syndrome
B. Hypercalcemia
C. Hypertrophic pulmonary osteo-arthropathy
D. Clubbing
E. All of the above are paraneoplastic syndrome of bronchogenic carcinoma
16. uFP is increased in the following EXCEPT:

A. Hepatocellular carcinoma
B. Cirrhosis
C. Carcinoma of colon
D. Lactation
E. Bronchogenic carcinoma

ANSWERS:
1. C I 1. B
2. D 12. A
3. E 13. B
4. B 14. E
5. D 15. A
6. A 16. D
7. C
8. E
9. D
10. C
POSSIBLE VIVA TOPICS:

1. Benign vs Malignant neoplasm *
2. Dysplasia vs Metaplasia vs Neoplasm *
3. Routes of malignant spread

4. Oncogenes & antioncogenes in tumorigenesis
5. Tumor invasion & metastatsis - mechanism
6. Effect of tumor on host
*
similar questions in previous exams.

047 Pathology MCQ ACEM Primary Neoplasia

Uploaded by

Copyright:

Available Formats

047 Pathology MCQ ACEM Primary Neoplasia

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

047 Pathology MCQ ACEM Primary Neoplasia

Uploaded by

Copyright:

Available Formats

NEOPLASMS

1. Which of the following is NOT a sign of anaplasia?

2. Malignant tumors has the following characteristics:

4. Which of the following skin tumor does NOT metastasize?

5. Normal nuclear: cytoplasmic ratio is:

PATHOLOGY NEOPLASM - MCQ

8. Which of the following statements regarding tumorigenesis is TRUE?

9. Which of the following statement is FALSE?

10. Maximum size of tumor compatible with life has:

1 1. Neoplastic growth has the following characteristics:

PATHOLOGY - NEOPLASM - MCQ 2

13. Cushing's syndrome may occur as a paraneoplastic syndrome in:

14. PTHrP is commonly expressed by:

15. Which of the following is NOT a paraneoplastic syndrome in bronchogenic

16. uFP is increased in the following EXCEPT:

PATHOLOGY - NEOPLASM - MCQ 3

POSSIBLE VIVA TOPICS:

2. Dysplasia vs Metaplasia vs Neoplasm *

3. Routes of malignant spread

PATHOLOGY - NEOPLASM - MCQ 4

You might also like