Cancer of The Breast
Cancer of The Breast
Cancer of The Breast
Lesson 1: Introduction
Lesson 2: Breast Cancer
Lesson 3: Lung Cancer
Lesson 4: Colorectal Cancer
Lesson 5: Cervical Cancer
Lesson 6: Uterine Cancer
Lesson 7: Prostate Cancer
Lesson 8: Liver Cancer
Lesson 9: Leukemia
Lesson 10: Brain Cancer
INTRODUCTION
Breast cancer is the number cause of cancer in females. You may already know someone
or may have encountered someone, at least, who have been diagnosed with this condition. The
thing is, the incidence of breast cancer has grown and is still growing. In your clinical encounters
as a student nurse, there is a great possibility that you might be given the responsibility to take
care of an individual with breast cancer. It is therefore, best for you to know the nature of this
disease in order for you to be prepared to take care of not only the sick individual with breast
cancer but also for those who are identified as high risk.
STATEMENT OF OUTCOMES
In this lesson, we will be discussing about the nursing process approach on the care of
clients suffering from cancer of the breast. At the end of this this lesson, the learners will be
able to:
1. Define breast cancer.
2. Differentiate the different types of breast cancer.
3. Explain the pathophysiology of breast cancer.
4. Identify and explain the risk factors for breast cancer.
5. Explain the causes of the manifestations of breast cancer.
6. Identify and explain the diagnostic examinations for breast cancer.
7. Identify and explain the managements for breast cancer.
8. Apply the nursing process in caring for clients with breast cancer.
WARM-UP ACTIVITY
You are assigned as the nurse in-charge of the Out-Patient Clinic and a woman came to
you at the station and says, “I am worried, I think I have breast cancer.” While talking to her,
you learned that she is only 35 years old and single. She said that her aunt has just been
diagnosed with breast cancer and her first degree cousin is a breast cancer survivor as well.
1. What could be the reason why the woman thinks she has breast cancer?
MODULE IN BREAST CANCER – MMSU CHS 2
2. Basing from this scenario, do you think the woman has breast cancer?
Breast Cancer is a malignant new growth that originates from the breast tissues and other
structures of the breast like the milk ducts, lobules or tubules. It is the number one cause of
cancer in females and second only to lung cancer as the leading cause of cancer deaths in
females.
Types of Breast cancer
Breast Cancer in Situ is a type of breast cancer in which cancer cells remained contained
within their place of origin and haven’t invaded breast tissue around the duct or lobule.
It has two types which includes:
o Ductal carcinoma in situ originates from the linings of milk ducts that haven’t
invaded the surrounding breast tissue. They are sometimes considered as
precancerous tumors in which if detected and treated at an early stage results to
good prognosis and when left untreated might progress to the invasive type of
breast cancer
o Lobular carcinoma in situ (LCIS) originates within a lobule of a breast but haven’t
invaded the surrounding breast tissue
Invasive breast cancers are the aggressive type of breast cancers wherein they invade
the surrounding tissues that support ducts and lobules of the breast. The tumor cells of
this type can travel to distant parts such as lymph nodes. It also has two types which
include:
o Invasive ductal carcinoma (IDC) forms at the lining of milk duct and accounts for
the majority of the invasive type of breast cancer. Tumor cells break free of
ductal walls and invade surrounding breast tissues
o Invasive lobular carcinoma (ILC) is the less common and acts in similar manner
wherein it starts at milk producing lobules and invades surrounding breast
tissues
Other Types
Medullary Carcinoma occurs when tumor cells grow in a capsule inside a duct. They can
become large and can be mistaken for a fibroadenoma which is a solid, non-cancerous
breast lump. It accounts for about 5% of breast cancers and women less than 50 years
old are often affected by this type. Medullary carcinomas often have favorable
prognosis.
Mucinous carcinoma is a slow growing type of breast tumor which has the ability to
produce mucin—the main ingredient of mucus hence the name. It accounts for about
3% of breast cancers. This often presents in post menopausal women 75 years and older
with a favorable prognosis compared to many other types.
Tubular ductal carcinoma are sometimes considered as a subtype of IDC that starts in
the milk ducts and extends to other parts of the breast. The cancer cells of this type
resemble small tubes when examined under a microscope hence the name. It accounts
for about 2% of breast cancers and although they are considered as invasive types,
axillary metastasis uncommon and prognosis is often excellent.
Inflammatory carcinoma is an aggressive type of breast cancer which may present as an
indiscrete thickening along with diffused edema and brawny erythema of the skin also
MODULE IN BREAST CANCER – MMSU CHS 3
known as Peau d’orange. This results when cancer cells block lymph channels in the skin.
This is a rare type of breast CA which accounts for only 1-2% of cases.
Paget disease of the breast is an uncommon type of breast cancer that originates in or
around the nipple. It accounts for 1% of cases and presents as scaly, erythematous and
pruritic lesion of the nipple.
ACTIVITY NO. 1
Copy and paste this table in a separate document and identify the type of breast cancer
described.
1. Sometimes considered as precancerous lesions that
Click or tap here to enter originates in milk ducts.
text.
2. An invasive type of breast CA that starts at the milk
Click or tap here to enter producing lobules.
text.
3. This type of breast CA causes blockage of lymph channels
Click or tap here to enter in the skin.
text.
Click or tap here to enter 4. Cancer cells of this type originates in or around the
text. nipple.
5. It originates within a lobule of a breast but haven’t
Click or tap here to enter invaded the surrounding breast tissue
text.
6. This is an invasive type of cancer wherein tumor cells
Click or tap here to enter resemble small tubes when examined under a
text. microscope.
Click or tap here to enter 7. Tumor cells originates from ducts and are encapsulated.
text.
Click or tap here to enter 8. A slow growing breast tumor that produces mucin.
text.
Click or tap here to enter 9. Most common type of invasive breast cancer.
text.
10. Originates within a lobule of a breast but haven’t invaded
Click or tap here to enter the surrounding breast tissue
text.
Risk Factors
Gender - women accounts for 99% of breast cancer cases
Age - majority of breast cancers are found in postmenopausal women; incidence increases
significantly at age 60
MODULE IN BREAST CANCER – MMSU CHS 4
Reproductive factors - prolonged exposure to unopposed estrogen increases risk for breast
cancer which includes nulliparity and late first pregnancy at after the age of 35 years old
Hormonal Factors – estrogen exposure in women with early menarche (before age 12) and
late menopause (after age 55) as well as estrogen therapy in post-menopausal women and
contraceptive use have higher risk for the development of breast cancer
Environmental and lifestyle – exposure to carcinogens including cigarette smoking and
alcohol consumption of more than 1 alcoholic beverage per day increases the risk of breast
cancer; obesity also increases breast cancer risk due to increase in circulating estrogen;
breast CA risk is decreased in physically active women
Familial factors and tumor related genes – inherited mutations in BRCA1 and BRCA2 genes
as well as p53 genes significantly increases risk; family history of breast cancer in first
degree relatives also increases breast cancer risk
Previous medical history – history of breast tumors such as moderate or florid mammary
hyperplasia, mammary papilloma and atypical mammary hyperplasia increases breast
cancer risk; prior treatment of Hodgkin’s lymphoma through ionizing radiation damages cell
DNA posing risk for development of breast CA
Protective Factors
Protective factors may include regular vigorous exercise (decreased body fat), pregnancy before
age 30 years, and breastfeeding.
Prevention Strategies
Patients at high risk for breast cancer may consult with specialists regarding possible or
appropriate prevention strategies such as the following:
Long-term surveillance consisting of twice-yearly clinical breast examinations starting at
age 25 years, yearly mammography, and possibly MRI (in BRCA1 and BRCA2 carriers)
Chemoprevention to prevent disease before it starts, using tamoxifen (Nolvadex) and
possibly raloxifene (Evista)
Prophylactic mastectomy (“risk-reducing” mastectomy) for patients with strong family
history of breast cancer, a diagnosis of lobular carcinoma in situ (LCIS) or atypical
hyperplasia, a BRCA gene mutation, an extreme fear of cancer (“cancer phobia”), or
previous cancer in one breast
ACTIVITY NO. 2
Make a list of the possible risk-assessment questions using three languages. Refer to the
example below.
ENGLISH TAGALOG ILOCANO
Are there any members of Mayroon bang miyembro ng Adda kadi miyembro ti
your family or immediate pamilya ninyo o sa mga pamilya yo wennu asideg nga
relatives who have had malapit na kamag-anak ang kabagyan yo nga addaan ti
breast cancer? may kancer sa suso? kanser ti suso?
Clinical Manifestations
MODULE IN BREAST CANCER – MMSU CHS 5
Presence of fixed, irregular, non- encapsulated and non-tender lump usually in upper
outer quadrants (because it is where the largest breast tissue can be found) is usually
the first sign of breast cancer. It may also be firm, hard and embedded in surrounding
tissues, which may only be palpable after 2 years.
Asymmetry observed on examination with affected breast being higher
Retraction or dimpling of the skin over the mass if tumor infiltrates surrounding tissues,
which is secondary to fibrosis or scar formation in the breast. It may appear only with
position changes or with breast palpation.
Nipple retraction as a result of shortening of mammary gland
Peau d’orange
Bloody or clear nipple discharges which may be due to obstruction
Lymph edema of the affected arm due obstruction of lymphatic circulation
Unilateral increased venous
Axillary lymphadenopathy/ nodular axillary mass
MODULE IN BREAST CANCER – MMSU CHS 6
Late manifestations
Nodule becomes more fixed to the chest wall
Pain as a result of pressure of the growing tumor
Ulceration as a result of decreased blood supply leading to necrosis
Systemic manifestations such as cachexia, weight loss, body malaise, anorexia, body
weakness, pallor
Manifestations of metastasis
Lung and pleura - productive sputum production; diminished breath sounds; dyspnea;
cough; chest pain
Liver - hepatomegaly; jaundice; ascites; RUQ pain
Bone (spine, proximal long bone) - spinal punch; tenderness; aching; fracture;
hypercalcemia
Brain – Papilledema (swelling of the optic nerve); corresponding abnormality in mental
status; increased ICP; headache; impaired cognitive function; hemiparesis, seizure,
visual changes
Prognosis
When malignancy is confirmed to breast - 5 years survival, 85 %
When malignancy has spread to axilla- 5 years survival, 55 %
Important factors to consider:
Tumor size - the smaller the size, the better the prognosis
Spread to lymph nodes under the arm (axilla) and surrounding structures – more
lymph nodes and surrounding structures involved, the poorer prognosis; distant
metastases or presence of secondary tumor always lead to poor prognosis
Examiner gently abducts the patient’s arm from the thorax. With left
hand, patient’s left forearm is grasped and supported. Right hand is then
free to palpate the axilla.
Any lymph nodes that maybe lying against the thoracic wall are noted;
Normally, these lymph nodes are not palpated, but if enlarged, their
location, size, mobility, consistency are noted
o For male, follow the same procedure
o BSE is best performed after menses - days 5-7, counting the first day of menses
as day 1
Note:
*Adolescent breast – firm and lobular
*Postmenopausal – thinner and fattier
*Pregnancy and lactation – firmer and larger with lobules more distinct
*Menstruating – Cysts are common, well defined and freely movable
*Malignant – hard, poorly defined, non-tender
Mammography
o Can detect non-palpable lesions (<1cm)
o Takes about 15 minutes and can be performed in hospital radiology department/
independent imaging center
o 2 views are taken of each breast – mechanically compressed from top-bottom
(craniocaudal view) and side-side (mediolateral oblique view)
o Women may experience some fleeting discomfort because maximum
compression is necessary for proper visualization
o New mammogram is compared with previous ones and any changes may
indicate a need for further investigation
o False (-) ranges between 5-10%
o Younger women and those taking hormonal therapy – more difficult to detect
lesions due to dense breast tissue
o The radiation exposure is = 1 hour of sunlight exposure
o Those with history of breast cancer – screening should begin 10 years earlier
than the age at which the youngest family member developed breast cancer but
not before 25 years of age
Galactography
o Involves injection of <1ml of radiopaque material through a canula inserted into
a ductal opening on areola, followed by mammogram
o To evaluate abnormality within duct when patient has bloody nipple discharge
on expression, spontaneous nipple discharge or solitary dilated duct on
mammogram
Ultrasound
o Diagnostic adjunct to mammogram to help distinguish fluid-filled cysts from
other lesions
o A thin coating of lubricating jelly is spread over the area, transducer
o Accurate but can’t definitively rule out malignant lesions
MODULE IN BREAST CANCER – MMSU CHS 8
ACTIVITY NO. 3
Copy and paste the table in a separate document and label the images according to what
method of BSE is used.
Click or tap here to enter text. Click or tap here to enter text. Click or tap here to enter text.
T – Primary
Tumor Size
Tx Primary tumor cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ: intraductal carcinoma, lobular carcinoma in situ,
or Paget disease of the nipple with node
T1 Tumor 2 cm or less in greatest dimension
T2 Tumor more than 2 cm but not more than 5 cm in greatest
dimension
T3 Tumor more than 5 cm in greatest dimension
T4 Tumor of any size with direct extension to chest wall or skin
N – Regional
Lymph Nodes
Nx Regional lymph nodes cannot be assessed ( e.g., previously removed)
N0 No regional lymph node metastasis
N1 Metastasis to movable ipsilateral axillary lymph node or nodes
N2 Metastasis to ipsilateral axillary lymph node(s) fixed to one another
or to other structures
N3 Metastasis to ipsilateral internal mammary lymp node or nodes
M- Distant
Metastasis
Mx Presence of distant metastasis can not be assessed
M0 No distant metastasis
M1 Distant metastasis (includes metastasis to ipsilateral supraclavicular
MODULE IN BREAST CANCER – MMSU CHS 10
Management
Surgical – the goal of surgery is to obtain local control of the disease
Types of Surgical Intervention:
o Breast conservation
Lumpectomy (tylectomy, tumorectomy) is the removal of circumscribed area
around and including tumor
Quadrantectomy is the removal of breast quadrant that includes the tumor
Partial/ segmental mastectomy is the removal of the tumor and 2-3 cm
wedge of normal tissue surrounding it and also a portion of the overlying skin
and underlying fascia that envelops the breast and chest muscle
o Total mastectomy is the removal of the entire breast but pectoralis muscles are left
intact
o Modified radical mastectomy is the removal of the entire breast including pectoralis
minor muscle, some or most of the axillary lymph nodes. This is used to treat
invasive breast cancer. A drain is inserted to remove serous fluid that collects under
skin --- promotes healing and decreases potential infection.
o Classical radical mastectomy (Halsted) is the removal of breast, underlying muscles
of the chest wall, nodules and lymphatic of axilla
Radiation Therapy – the goal of RT is 1) to decrease the chance of local recurrence on breast
by eradicating residual microscopic cancer cells; 2) serves as an adjunct therapy with
surgery; 3) to shrink large tumor to operable size; 4) to alleviate pain caused by metastasis;
and 5) as primary therapy
MODULE IN BREAST CANCER – MMSU CHS 11
Methods:
o External Beam Radiation starts at about 6 weeks after surgery to allow surgical site
to heal or after completion of chemotherapy. Each treatment lasts for 5 minutes, 5
days/week, for 5-6 weeks then a “boost” dose of RT is given after completion.
o Brachytherapy involves placing a radioactive source within lumpectomy site. It is
administered for 4-5 days.
o Intra operative RT (IORT) is the use of single intense dose of RT that is delivered in
surgical site in OR immediately following lumpectomy
Side Effects
Mild to moderate erythema, breast edema, fatigue
Skin breakdown in inflammatory fold or near axilla which occurs few weeks to few
months after treatment is completed
Pneumonitis, rib fracture, breast fibrosis
Nursing Management
Use mild soap with minimal rubbing
Avoid perfumed soap or deodorant
Use hydrophilic lotion (Aquaphor, Lubriderm) for dryness
Avoid tight clothes, under wire bras, excessive temperature, UV light
Minimize sun exposure to the treated area
Chemotherapy - Adjuvant therapy; for patient with lymph nodes involvement or invasive
tumor >1 cm, regardless of nodal status. It is given for 3-6 months and may include single or
combined antineoplastic drugs :
o Cyclophosphamide, Methotrexate, Fluorouracil (CMF)
o Taxanes (Paclitaxel, docetaxel)
Side Effects: Nausea/vomiting, BM suppression, taste changes, fatigue, weight gain >10 lbs,
permanent or temporary amenorrhea causing sterility
Hormonal Therapy is indicated for women who have hormone receptor-positive tumors,
which is determined by the results of an estrogen and progesterone receptor assay. About
2/3 of breast cancer are dependent on estrogen for growth and express a nuclear receptor
that binds to estrogen [ESTROGEN RECEPTOR (+)/ER (+)]. HT involves the use of medications
that compete with estrogen by binding to receptor sites. Similarly, tumor that express
progesterone receptor that are called progesterone receptor (+)/ PR (+). Tumors which are
ER (+)/ PR (+) – greatest likelihood to respond to HT with more favorable prognosis than ER
(-)/ PR (-). It is more commonly for used in postmenopausal women.
MODULE IN BREAST CANCER – MMSU CHS 12
Targeted Therapy
o Trastuzumab (Herceptin) is a monoclonal antibody that binds especially to HER –
2/neu protein. It regulates cell growth; (+) in small amount in surface of normal
breast cells and most breast cancers. Approximately 25-30% of tumors over express
it and are associated with rapid growth and poor prognosis. Trastuzumab targets
and inactivates the HER – 2/neu protein --- slowing tumor growth. Unlike
chemotherapy, it spares normal cells and has limited adverse reactions including
fever, chills, nausea/vomiting, diarrhea and headache. It may be administered as
single agent or in combination with chemotherapy.
MODULE IN BREAST CANCER – MMSU CHS 13
WRAP-UP ACTIVITY
Instruction: Choose the letter that best answers the question.
Continuation…
7. The client is to receive Cyclophosphamide for chemotherapy, which of the following
medications are given to prevent side-effects?
A. Leucovorin Calcium
B. Amifostine
C. Nitroomidazoles
D. MESNA
8. This drug inhibits the conversion of estradiol to estrogen in post-menopausal thereby
decreasing circulating estrogen in the body and minimizing breast cancer risk.
A. Transtuzumab
B. Tamoxifen
C. 5-Fluorouracil
D. Anastrazole
9. One of the general side-effects of chemotherapy is alopecia or loss of hair, as the nurse
in charge, when should you advise the client to buy her wig?
A. When there is minimal loss of hair
B. Before she starts losing her hair
C. Until all of her hair falls off
D. When she is half bald
10. The patient is for modified radical mastectomy, right breast. Which of the following is an
appropriate health teaching?
A. Use protective gloves when gardening
B. Avoid doing the laundry
C. Use arm sling for at least 4 weeks
D. Limit movement on your right hand
11. Which of the following manifestations would suggest metastasis of breast cancer?
A. Significant weight loss
B. Severe anemia
C. Difficulty of breathing
D. Orange discoloration of breast
12. Which of the following is an appropriate management for a non-invasive ductal
carcinoma?
A. Total mastectomy
B. Breast conservation treatment
C. Modified radical mastectomy
D. None of the above
MODULE IN BREAST CANCER – MMSU CHS 19
Continutation…
13. The patient worries that her husband won’t find her attractive after her mastectomy,
which of the following is an appropriate nursing diagnosis?
A. Decisional conflict related to lack of knowledge about treatment options and
their effects
B. Fear and anxiety related to diagnosis of breast cancer
C. Disturbed body image related to anticipated physical and emotional effects of
treatment modalities
D. Risk for infection related to immunosuppression
14. Which of the following is NOT included in the CAF chemotherapy protocol for high risk
breast cancer patients?
A. Cyclophosphamide
B. Adriamycin
C. Cisplatin
D. Fluorouracil
15. The patient asks you why should the chemotherapy be given in sessions, your best
response is:
A. It will minimize the occurrence of nadir
B. It will allow your normal cells to repair
C. It will maintain therapeutic serum level of the drugs
D. It will prevent the occurrence of side-effects
POST-ASSESSMENT
(A post-assessment quiz will be administered via MVLE.)
REFERENCES
Borromeo, A.R. Lewis, S.L. Dirksen, S. (2014). Lewis’s Medical Surgical Nursing: Assessment and
Management of Clinical Problems Philippine Edition (8th ed) Singapore: Elsevier
(Singapore) Pte Ltd
Hinkle, J.L. Cheever, K.H. (2014). Brunner & Suddarth’s Textbook of Medical-Surgical Nursing
(13th ed). Philadelphia: Lippincot Williams & Wilkins
Handbook for Brunner and Suddarth's textbook of medical-surgical nursing. (2010). Philadelphia:
Wolters Kluwer Health/Lippincott Williams & Wilkins.