TEST

Pharmaceutics Subject Wise Test (Major)

QUESTIONS

SECTIONS

1. Pharmaceutics - 100 Questions

Section 1 : Pharmaceutics - 100 Questions

1 What is the IP specification for solubility of sparingly soluble compounds?

1 part in 10-30 parts of solvent

1 part in 30-100 parts of solvent
1 part in 100-1000 parts of solvent 
1 part in 1-10 pats of solvent

Correct: +1 · Incorrect: -0.25

2 Cold place as per IP indicates storage at

2-8oC

8-25 oC

0 oC

25 oC

Correct: +1 · Incorrect: -0.25

3 Zanasi instrument is used for

To determine particle size

To determine rheology of semisolids 
For tablet coating
Capsule machine

Correct: +1 · Incorrect: -0.25

4 The stability of suspension can be evaluated by

 Sedimentation volume
Degree of flocculation
Re-dispersibility
All the above

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 1 of 26

 5 1 Fluid ounce is equal to

60 ml
30 ml
120 ml
90 ml

Correct: +1 · Incorrect: -0.25

6 Acid hydrolysis of ester followed which type order of reaction ?

Zero
Second
First
None

Correct: +1 · Incorrect: -0.25

7 ----------------microencapsulation technique is suitable for coating of only solids

Air suspension
Pan coating
Solvent evaporation
Both a & b

Correct: +1 · Incorrect: -0.25

8 Mottling is referred to deformity in

Colour
Shape
Thickness
Flavour

Correct: +1 · Incorrect: -0.25

9 ------------------is trade name of croscarmellose sodium which is used as superdisintegrant

Ac-di-sol
Primogel  
 Polyplasdone  
 Explotab

Correct: +1 · Incorrect: -0.25

10  The  change of a state from a solid directly to a gas is called as

Evaporation
Fusion

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 2 of 26

 Sublimaton
Boiling

Correct: +1 · Incorrect: -0.25

11 Which of the following dosage form is suitable for to get 100% bioavailability of drug?

Tablet  
Capsule
I V injection
Transdermal patch

Correct: +1 · Incorrect: -0.25

12 Water attack test is used to identify the alkalinity in

Type-I glass
Type-II glass
Type-III glass
All the above

Correct: +1 · Incorrect: -0.25

13 Mixing of semisolid is carried out using

Double cone mixer

Rotating cube mixer
Planetary mixer
Fluidized bed mixer

Correct: +1 · Incorrect: -0.25

14 First order half-life is equal to

1/k
K
 0.693/k
2k+1

Correct: +1 · Incorrect: -0.25

15 A super disintegrant in tablet formulation is

Sodium starch glycolate

Starch
PVP
Mg-Aluminium silicate

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 3 of 26

 16 Temperature range for the dissolution test as per IP

37±1C
37±0.1C
37±2C
37±0.5C

Correct: +1 · Incorrect: -0.25

17 Following is the true order of solubility:

Amorphous>metastable>stable 
Metastable>amorphous>stable
Stable>amorphous>metastable
Stable>metastable>amorphous

Correct: +1 · Incorrect: -0.25

18 Separation of tablet into two or more distinct layers is

Picking    
Capping
Lamination 
Broken

Correct: +1 · Incorrect: -0.25

19 Creaming is a ------------ process ?

Reversible
Irreversible
Diffficult
Both b and c

Correct: +1 · Incorrect: -0.25

20 HLB system was developed by

Griffin
Stock’s
Dalla Valle
Crook

Correct: +1 · Incorrect: -0.25

21 Bulk density and tapped density’s relation is explained by

Hausner’s ratio
Angle of repose

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 4 of 26

 Tan Ɵ
All the above

Correct: +1 · Incorrect: -0.25

22 ------------------acts as preservative

Methyl paraben
Propyl paraben
Benzoic acid
All the above

Correct: +1 · Incorrect: -0.25

23  The Dip tube in an aerosol container is made from

 

Poly propylene
Glass
Al
Stainless steel

Correct: +1 · Incorrect: -0.25

24 -----------------is used to adjust isotonicity

Dextrose
Boric acid
Sodium chloride
All the above

Correct: +1 · Incorrect: -0.25

25 Which one of the following propellant is used in the aerosol for oral use

Propane
Oxygen
Methane
Trichloro monofluoro methane

Correct: +1 · Incorrect: -0.25

26  As per IP , the percentage of sucrose in simple syrup is

56 % w/w
66.7 % w/v
66.7 %w/w
85 % w/w

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 5 of 26

 27  If the Carr’s index of a powder is 10 %  then the type of powder flow is

Poor
Excellent
Very poor
Good

Correct: +1 · Incorrect: -0.25

28 On which factor the rate constant of a reaction does not depend upon ?

Temperature
Activation energy
Catalyst
Concentration of reactants and products

Correct: +1 · Incorrect: -0.25

29 Lecithin is incorporated in shampoo as

Conditioning agent
Clarifying agent
Opacifying agent
PH adjusting agent

Correct: +1 · Incorrect: -0.25

30 In extemporaneous preparation of a suspension ,levigation is used to

Reduce viscosity
Reduced Zeta potential
Reduce particle size
Avoid bacterial growth

Correct: +1 · Incorrect: -0.25

31 Reynold’s number of steamline flow should be

<0.2< p>
>0.2
<0.8< p>
>0.8

Correct: +1 · Incorrect: -0.25

32  Creatinine clearance is used as a measurement of

Passive renal absorption

Glomerular Filtration rate

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 6 of 26

 Renal excretion rate
All

Correct: +1 · Incorrect: -0.25

33  Moisture content of empty gelatin capsule lie in the range of

Below 10 %
12-15 %
Above 16 %
Above 20 %

Correct: +1 · Incorrect: -0.25

34 Cryoscopic method of calculation of isotonic concentration is based on

Freezing point depression

Molar Concentration
Sodium chloride equivalent method
None of the above

Correct: +1 · Incorrect: -0.25

35 Very fine powder must pass through sieve no

22
44
120
85

Correct: +1 · Incorrect: -0.25

36 In tablet coating process, inadequate spreading of coating solution before drying causes

Orange peel effect

Sticking effect
Blistering effect
Picking effect

Correct: +1 · Incorrect: -0.25

37 The first and most widely used diluents in tablet formulation is

Dextrose
Lactose
MCC
Starch

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 7 of 26

 38 Which of the following is the first process that must occur before  a drug can become available for absorption from a
tablet dosage form

Dissolution of the drug in GI fluids

Dissolution of the drug in epithelium
Ionization of the drug
Disintegration of the drug

Correct: +1 · Incorrect: -0.25

39 Which of the following apparatus can be used for determining the viscosity of Non-newtonian fluids

Ostwald viscometer
Brookfield viscometer
Falling sphere viscometer
Ubbelohde viscometer

Correct: +1 · Incorrect: -0.25

40 For an ideal suspension sedimentation volume should be

More than 1
Equal to 1
Zero
Less than 1

Correct: +1 · Incorrect: -0.25

41 ------------acts as humectants

Propylene glycol
Sorbitol
Glycerol
All the above

Correct: +1 · Incorrect: -0.25

42 BCS class-III drugs possess

Low solubility and low permeability

High solubility and low permeability
Low solubility and high permeability
High solubility and high permeability

Correct: +1 · Incorrect: -0.25

43 When the solvent in association with the drug is water, the solvate is known as

Anhydrate
Amorphous

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 8 of 26

 Hydrate
None

Correct: +1 · Incorrect: -0.25

44 The term bioavailability refer to the relative amount of drug that reaches

Small intestine
Stomach
Liver
Systemic circulation

Correct: +1 · Incorrect: -0.25

45 Seal coating is applied for

Taste masking
Sustaining release instant release
Prevention of moisture content
All the above

Correct: +1 · Incorrect: -0.25

46 The time required for drugs to start producing pharmacologicl response is known as

Duration of action
Onset of action
Onset time
Therapeutic index

Correct: +1 · Incorrect: -0.25

47 Department of Transport test (DOT)  is performed for

Aerosols
Ointment
Emulsions
None

Correct: +1 · Incorrect: -0.25

48  Guidelines on stability testing of drugs are given in

ICH 
USFDA 
Both 
None

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 9 of 26

 49  Addition of enough CaCl2 in emulsion stabilized by a soap solution causes

Cracking of emulsion
Phase inversion from o/w to w/o
Phase inversion from w/o to o/w 
Precipitation of emulsifier

Correct: +1 · Incorrect: -0.25

50 Tablets which are placed between cheek and teeth are known as

Buccal
Sublingual
Lozenges
Troches

Correct: +1 · Incorrect: -0.25

51 Flow rate of granules from the hopper can be improved by adding

Disintegrant
Glidant
Binder
Lubricant

Correct: +1 · Incorrect: -0.25

52 Viscosity of suspension is determined by

Ostwald’s viscometer
Capillary viscometer
 Brookfield viscometer
Cone and plate viscometer

Correct: +1 · Incorrect: -0.25

53  Young formula for calculating child dose

Age in years+20×adult dose

Age (year)+Age+12×Adult dose
Age in year +1/2×Adult dose
Age in year+Age+12×1/2×Adult dose

Correct: +1 · Incorrect: -0.25

54 Other than tablet hardness, which method is used to measure the tablet strength

Thickness
Weight variation

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 10 of 26

 Friability
Organoleptic properties

Correct: +1 · Incorrect: -0.25

55 The commonly used diluent  in chewable tablet formula is

Sucrose
Mannitol
Lactose
Saccharin sodium

Correct: +1 · Incorrect: -0.25

56 In capsules, ROTOFIL is used for filling

Powders
Pellets
Liquids
Corrosive liquids

Correct: +1 · Incorrect: -0.25

57 ICHQ4 guideline  is for

Test methods
Pharmacopoeias
New products development
None

Correct: +1 · Incorrect: -0.25

58 Look at this series: 21,9,21,11,21,13,21---------what number should come next

12
14
15
17

Correct: +1 · Incorrect: -0.25

59 Vulcanising agent used in rubber is

Mineral Oil
Thiazoles
Sulphur
Sulphides of iron

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 11 of 26

 60 BHT stands for

Butylated hydrated trioxide

Butylated hydroxyl toluene
Butelene hydroxide toluene
Butylated hydroxyl terpene

Correct: +1 · Incorrect: -0.25

61 What is the pH of human tears

6.2
7.4
8.0
9.0

Correct: +1 · Incorrect: -0.25

62 The quantity of the drug which displace one part of the base is called

Saponification value
Displacement value
Acid value
Iodine value

Correct: +1 · Incorrect: -0.25

63 The condition required for autoclave

1210c temp & 20lbs .pressure for 30 min

1210c temp & 15 lbs .pressure for 15 min

1500c temp for 1 hr

1300c temp for 2 hr

Correct: +1 · Incorrect: -0.25

64  The first edition of the pharmacopoeia of India was published in the year.

1947
1955
1966
1946

Correct: +1 · Incorrect: -0.25

65 BET equation is used for measurement of

Tensile strength

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 12 of 26

 Porosity
Bioavailability
Surfacearea

Correct: +1 · Incorrect: -0.25

66 The identification of propellants in pharmaceutical aerosols is carried out by

 (P) Gas chromatography                      (Q) Pycnometer
  ( R) Tag open cup apparatus                 (S) IR spectrophotometer

P, Q
P,S
Q,R
R,S

Correct: +1 · Incorrect: -0.25

67  Instrument used to measure the hardness of tablet is  

Monsanto
Pfizer tester 
Strong cob 
All the above

Correct: +1 · Incorrect: -0.25

68  Type B gelatin is having isoeletric point in the region _______.

2-3 
4-5 
6-7 
8-9

Correct: +1 · Incorrect: -0.25

69  The function of the lubricant in tablet formation is

Improving flow properties of granule

Reducing punch and die wear
Facillitating tablet ejection from the die
All the above

Correct: +1 · Incorrect: -0.25

70 The disintegration time for sugar coated tablets is

30 min
60 min
90 min
15 min

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 13 of 26

 Correct: +1 · Incorrect: -0.25

71 Friabilator is operated at

100 RPM
75 RPM
50 RPM
25 RPM

Correct: +1 · Incorrect: -0.25

72 The diameter of the mesh aperture in the I.P. disintegration apparatus is given below. choose the correct size

2 mm
4 mm
1 mm
1.5 mm

Correct: +1 · Incorrect: -0.25

73 Ratio of dry glycerin/dry gelatin for hard gelatin capsules is`

0.6 : 1
0.4 : 1
0.8 : 1
1 : 0.8

Correct: +1 · Incorrect: -0.25

74 Which of the following is not an antioxidant

BHT
BHA
Tocopherol
Theobroma oil

Correct: +1 · Incorrect: -0.25

75 ---------------jellies are sometimes called Bassorin pastes

Tragacanth
Pectin
Starch
Sodium alginate

Correct: +1 · Incorrect: -0.25

76 The mechanism of dry heat sterilization is

Oxidation

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 14 of 26

 Protein coagulation
Alkylation
Hydrolysis

Correct: +1 · Incorrect: -0.25

77  Choose the one of the following gasses used for sterilization of medical products

Ethylene oxide  
Carbon dioxide 
Nitrous oxide
Nitrogen

Correct: +1 · Incorrect: -0.25

78 Roller mill is used mainly to reduce particle size in

Ointment
Tablet granulation
Capsules
Bulk powders

Correct: +1 · Incorrect: -0.25

79 Agglomeration  of particles in emulsion is called

Polymerisation
Coalescence
Dimerisation
Dichromatism

Correct: +1 · Incorrect: -0.25

80 Magnesium stearate is used as

Binder
Lubricant
Glidant
Diluent

Correct: +1 · Incorrect: -0.25

81 Passive diffusion

Means 90% of drugs get absorbed

Is usually slow
Requires no energy
All of the above

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 15 of 26

 Correct: +1 · Incorrect: -0.25

82 The area under the plasma level time profile curve represented the

Amount of drug excreted in urine

Amount of drug absorbed
Amount of drug that is cleaned by the kidney
Biological half-life of the drug

Correct: +1 · Incorrect: -0.25

83 ------------------method is used for determination  of particle size

Sieving
Sedimentation
Optical microscopy
All of the above

Correct: +1 · Incorrect: -0.25

84 ICH Q9 guideline is for

Safety assessment
Quality risk management
Product development
None

Correct: +1 · Incorrect: -0.25

85 Volume fill in 000 capsule size

1.37 ml
0.95 ml
0.68 ml
0.15 ml

Correct: +1 · Incorrect: -0.25

86 Aerosil is used as

Glidant
Lubricant
Anti adherent
Diluent

Correct: +1 · Incorrect: -0.25

87 ___________ is zwitterionic surfactant.

SLS

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 16 of 26

 Lecithin
Tween
Benzalkonium chloride

Correct: +1 · Incorrect: -0.25

88  Bloom is the measurement for _______ of gelatin molecules.

Cohesivenss
Dissolution
Adhesiveness 
Elasticity

Correct: +1 · Incorrect: -0.25

89  Stable form of cocoa butter is having melting point ____ C

 

 25
35 
45 
 55

Correct: +1 · Incorrect: -0.25

90 ______ contains highest amount of solid content

Ointment
Gel
Jellies
Paste

Correct: +1 · Incorrect: -0.25

91  Suspensions follows _______ order kinetics.

Zero order
Apparent zero order 
Both (a) and (b)
None of the above

Correct: +1 · Incorrect: -0.25

92  A synthetic sweetening agent which is approximately 200 times sweeter than sucrose and has no after taste is

Saccharine
Aspartame
Cyclamate
Sorbitol

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 17 of 26

 Correct: +1 · Incorrect: -0.25

93  Which one of the following plasma protein has high affinity for binding with drug?

HSA
1-acid glycoprotein

Lipoprotein
Globulins

Correct: +1 · Incorrect: -0.25

94  Which one of the following marker is used to measure total body water?

Antipyrine
Evans blue 
Na
Mannitol

Correct: +1 · Incorrect: -0.25

95 Surface tension of water at 200 c is

72.8 dynes /cm

72.8 N/m
75.6 dynes/cm
75.6 N/m

Correct: +1 · Incorrect: -0.25

96 Convert 1200 F into 0 c

370 c

470 c

48.90 c

50.20 c

Correct: +1 · Incorrect: -0.25

97 Drug release from diffusion controlled matrix tablets is explained by

Ishikawa
Toshiba
Higuchi
Noyes-Whitney

Correct: +1 · Incorrect: -0.25

98 Potential between the surface of the tightly bound layer and the electroneutral region of the solution called as

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 18 of 26

 Nernst potential
Electrodynamic potential
Zeta potential
None

Correct: +1 · Incorrect: -0.25

99 Suppositories used for ear infection are called

Rockets 
Cones 
Bougies
Pessaries

Correct: +1 · Incorrect: -0.25

100 Bingham bodies show which type of flow?

Newtonian flow 
Plastic flow
Pseudoplastic
Dilatant

Correct: +1 · Incorrect: -0.25

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Questions Page 19 of 26

 TEST

Pharmaceutics Subject Wise Test (Major)

ANSWERS

SECTIONS

1. Pharmaceutics - 100 Questions

Section 1 : Pharmaceutics - 100 Questions

1 1 part in 30-100 parts of solvent

2 2-8oC
3 Capsule machine
4 All the above
5 30 ml
6 First
7 Both a & b
8 Colour
9 Ac-di-sol
10 Sublimaton
11 I V injection
12 Type-II glass
13 Planetary mixer
14  0.693/k
15 Sodium starch glycolate
16 37±0.5C
17 Amorphous>metastable>stable 
18 Lamination 
19 Irreversible
20 Griffin
21 Hausner’s ratio
22 All the above
23 Poly propylene
24 All the above
25 Trichloro monofluoro methane
26 66.7 %w/w
27 Excellent
28 Concentration of reactants and products

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Answers Page 20 of 26

 29 Conditioning agent
30 Reduce particle size
31 <0.2< p>
32 Glomerular Filtration rate
33 12-15 %
34 Freezing point depression
35 120
36 Orange peel effect
37 Lactose
38 Disintegration of the drug
39 Brookfield viscometer
40 Equal to 1
41 All the above
42 High solubility and low permeability
43 Hydrate
44 Systemic circulation
45 All the above
46 Onset of action
47 Aerosols
48 Both 
49 Phase inversion from o/w to w/o
50 Buccal
51 Glidant
52  Brookfield viscometer
53 Age (year)+Age+12×Adult dose
54 Friability
55 Mannitol
56 Pellets
57 Pharmacopoeias
58 15
59 Sulphur
60 Butylated hydroxyl toluene
61 7.4
62 Displacement value
63
1210c temp & 15 lbs .pressure for 15 min
64 1955
65 Surfacearea

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Answers Page 21 of 26

 66 P,S
67 Pfizer tester  All the above
68 4-5 
69 All the above
70 60 min
71 25 RPM
72 2 mm
73 0.4 : 1
74 Theobroma oil
75 Tragacanth
76 Oxidation
77 Ethylene oxide  
78 Capsules
79 Polymerisation
80 Lubricant
81 All of the above
82 Amount of drug absorbed
83 All of the above
84 Quality risk management
85 1.37 ml
86 Glidant
87 Lecithin
88 Cohesivenss
89 35 
90 Paste
91 Apparent zero order 
92 Aspartame
93 HSA
94 Antipyrine
95 72.8 N/m
96 48.90 c
97 Higuchi
98 Zeta potential
99 Cones 
100 Plastic flow

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Answers Page 22 of 26

 TEST

Pharmaceutics Subject Wise Test (Major)

SOLUTIONS

SECTIONS

1. Pharmaceutics - 100 Questions

Section 1 : Pharmaceutics - 100 Questions

1 1 part in 30-100 parts of solvent

2
2-8oC
3 Capsule machine

4 All the above

5 30 ml

6 First

7 Both a & b

8 Colour

9 Ac-di-sol

10 Sublimaton

11 I V injection

12 Type-II glass

13 Planetary mixer

14  0.693/k

15 Sodium starch glycolate

16 37±0.5C

17 Amorphous>metastable>stable

18 Lamination       

19 Creaming

20 Griffin

21 Hausner’s ratio

22 All the above

23 Poly propylene
Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Solutions Page 23 of 26
 24 All the above

25 Trichloro monofluoro methane

26 66.7 %w/w

27 Excellent

28 Concentration of reactants and products

29 Conditioning agent

30 Reduce particle size

31 <0.2< p>

32 Glomerular Filtration rate

33 12-15 %

34 Freezing point depression

35 120       

36 Orange peel effect

37 Lactose

38 Disintegration of the drug

39 Brookfield viscometer

40 Equal to 1

41 All the above

42 High solubility and low permeability

43 Hydrate

44 Systemic circulation

45 All the above

46 Onset of action

47 Aerosols

48 Both

49 Phase inversion from o/w to w/o

50 Buccal

51 Glidant

52 Brookfield viscometer

53 Age (year)+Age+12×Adult dose

54 Friability

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Solutions Page 24 of 26

 55 Mannitol

56 Pellets

57 Pharmacopoeias

58 15       

59 Sulphur

60 Butylated hydroxyl toluene

61 7.4       

62 Displacement value

63 1210c temp & 15 lbs .pressure for 15 min

64 1955

65 Surface area

66 P,S

67 All the above

68 4-5

69 All the above

70 60 min

71 25 RPM

72 2 mm

73 0.4 : 1

74 Theobroma oil

75 Tragacanth

76 Oxidation

77 Ethylene oxide

78 Capsules

79 Coalescence

80 Lubricant

81 All of the above

82 Amount of drug absorbed

83 All of the above

84 Quality risk management

85 1.37 ml
Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Solutions Page 25 of 26
 86 Glidant

87 Lecithin

88  Cohesivenss

89 35

90 Paste

91 Apparent zero order

92 Aspartame

93 HSA

94 Antipyrine

95 72.8 N/m

96 48.90 c

97 Higuchi

98 Zeta potential

99 Cones

100 Plastic flow

Pharmaceutics Subject Wise Test (Major) · Pharmaceutics · Solutions Page 26 of 26