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    Connective Tissue Disease Cascade

    Uploaded by

    Yustina Bubnova
    Connective Tissue Disease Cascade

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Connective Tissue Disease Cascade

    Uploaded by

    Yustina Bubnova
    392 views1 page
    Connective Tissue Disease Cascade

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    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Connective Tissue Disease Cascade

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    392 views1 page

    Connective Tissue Disease Cascade

    Uploaded by

    Yustina Bubnova
    Connective Tissue Disease Cascade

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    Connective Tissue Disease Cascade (CTDC)

    CTDC / Connective Tissue Diseases Cascade, Serum

    STOP
    Cyclic citrullinated Antinuclear antibodies (ANA) <3.0 U
    No further testing required
    peptide antibodies, IgG

    ≥20 U <20 U ≥3.0 U

    Positive result supports the STOP


    diagnosis of rheumatoid arthritis No further testing required

    DNA double-stranded (dsDNA) Antibody to extractable nuclear Centromere Ribosome P


    antibodies with reflex, IgG antigen evaluation antibodies, IgG antibodies, IgG
    This test includes the following IgG
    antibodies, which are automatically
    30-75 IU/mL performed: ≥1.0 U ≥1.0 U
    >75 IU/mL ■ SS-A/Ro ■ RNP

    ■ SS-B/La ■ Scl 70

    ■ Sm ■ Jo 1
    Positive result supports the Positive result supports
    CRITH / DNA Double-Stranded Positive result supports the diagnosis of CREST (calcinosis, the diagnosis of SLE and
    (dsDNA) Antibodies by Crithidia diagnosis of systemic lupus Raynaud disease, esophageal may indicate the presence
    luciliae IFA, IgG, Serum erythematosus (SLE) motility disorder, sclerodactyly, of central nervous system
    and telangiectasia) syndrome involvement

    Positive result Negative result


    supports unable to confirm
    the diagnosis borderline positive SS-A/Ro Antibodies SS-B/La Antibodies Sm Antibodies RNP Antibodies Scl 70 Antibodies Jo 1 Antibodies
    of SLE result obtained
    by EIA ≥1.0 U ≥1.0 U ≥1.0 U ≥1.0 U ≥1.0 U ≥1.0 U

    Positive result supports Positive result Positive result Positive result Positive result Positive result
    the diagnosis of Sjögren supports diagnosis supports supports diagnosis supports supports
    syndrome or other connective of Sjögren syndrome diagnosis of SLE of mixed connective diagnosis of diagnosis of
    tissue disease (CTD) or other CTD tissue disease scleroderma polymyositis

    NOTE: Positive results are not diagnostic for any CTD and should be interpreted within the clinical context of the patient.

    © Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 01/2020

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