SAFETY DATA SHEET Version 6.

1
Revision Date 27.09.2019
according to Regulation (EC) No. 1907/2006 Print Date 14.09.2020
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Caffeine
Product Number : 56396
Brand : Sigma-Aldrich
Index-No. : 613-086-00-5
REACH No. : A registration number is not available for this substance as the
substance or its uses are exempted from registration, the
annual tonnage does not require a registration or the
registration is envisaged for a later registration deadline.
CAS-No. : 58-08-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
1 Science Park Road
#02-14 The Capricorn, S'pore Sci. PkII
SINGAPORE 117528
SINGAPORE
Telephone : +65 6779-1200
Fax : +65 6779-1822
1.4 Emergency telephone number
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

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 Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
Precautionary none
statement(s)
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C8H10N4O2
Molecular weight : 194,19 g/mol
CAS-No. : 58-08-2
EC-No. : 200-362-1
Index-No. : 613-086-00-5
Component Classification Concentration
Caffeine
Acute Tox. 4; H302 <= 100 %
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult
a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist
or gas. Ensure adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Store under inert gas. Moisture sensitive.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
Personal protective equipment

Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye
protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
[email protected], test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the CE approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must
be selected according to the concentration and amount of the dangerous substance
at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle
respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU
EN 143) respirator cartridges. Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN (EU).

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 Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: powder
Colour: white, colourless
b) Odour odourless
c) Odour Threshold No data available
d) pH 5,5 - 6,5 at 10 g/l at 20 °C

e) Melting 238 °C
point/freezing point
f) Initial boiling point No data available
and boiling range
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapour pressure 20 hPa at 89 °C
l) Vapour density No data available
m) Relative density 1,230 g/cm3 at 18 °C
n) Water solubility 18,7 g/l at 16 °C
o) Partition coefficient: log Pow: -0,091 at 23 °C
n-octanol/water
p) Auto-ignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Bulk density 220 kg/m3
Dissociation constant 10,4 at 40 °C

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SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen
oxides (NOx)
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - 367,7 mg/kg
(OECD Test Guideline 401)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LC50 Inhalation - Rat - male and female - 4 h - 4,94 mg/l
(OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
Germ cell mutagenicity
In vitro mammalian cell gene mutation test
mouse lymphoma cells
Result: negative
Chromosome aberration test in vitro

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 Human lymphocytes
Result: negative
Ames test
Escherichia coli/Salmonella typhimurium
Result: negative
Chromosome aberration test in vitro
Chinese hamster lung cells
Result: positive

Mouse - male
Result: negative
(ECHA)

Human
Result: negative
(ECHA)

Mouse - male
Result: negative
(ECHA)
OECD Test Guideline 474
Mouse - male and female - Red blood cells (erythrocytes)
Result: Positive results were obtained in some in vivo tests.
Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Caffeine)
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
Repeated dose toxicity - Mouse - male and female - Oral - 90 d - No observed adverse
effect level - 167,4 - 179,4 mg/kg
(ECHA)
RTECS: EV6475000

To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
After absorption of toxic quantities:
Diarrhoea, Vomiting, agitation, Headache
Systemic effects:
drop in blood pressure, tachycardia
Handle in accordance with good industrial hygiene and safety practice.
Liver - Irregularities - Based on Human Evidence

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SECTION 12: Ecological information
12.1 Toxicity
Toxicity to fish static test LC50 - Leuciscus idus (Golden orfe) - ca. 87 mg/l - 96 h
(DIN 38412 part 15)
static test NOEC - Leuciscus idus (Golden orfe) - 46 mg/l - 96 h
(DIN 38412 part 15)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 182 mg/l - 48 h
and other aquatic (DIN 38412)
invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 100
mg/l - 72 h
(OECD Test Guideline 201)
static test NOEC - Desmodesmus subspicatus (green algae) - 6,25
mg/l - 72 h
(OECD Test Guideline 201)
Toxicity to bacteria EC50 - activated sludge - > 1.000 mg/l - 3 h
(OECD Test Guideline 209)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 22 d
Result: 90 - 100 % - Readily biodegradable.
(OECD Test Guideline 301A)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator
equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to
a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
14.1 UN number
ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
14.4 Packaging group
ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
Further information
Copyright 2018 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact [email protected].

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