Subtitle - 2020-05-08T224930.852

Hello everyone.
Welcome to the course on Antimicrobial

resistance theory and methods. We would really thank that you
are enrolling for this course or maybe you are just thinking
of enrolling still. So here we have this welcome video as
an introduction to the course. It's not a real video lecture, as it is meant to
tell you much more
about what to expect in this course. So first of all, we'd like to introduce to
us, to me, for example, I'm Lina Cavaco. I'm a Senior Researcher at the research
group for Genomic Epidemiology. At the National Food Institute, which is located at
the technical
university of Denmark, and I have been working on Antimicrobial
Resistance for about ten years. And I do research and
teaching in this area. About other teaching stuff involved
in this course you will also have some presentations that
are going to be presented by Shinny. Shinny, Valeria and Susanne have also
helped in providing materials for this course and providing slides
that I'm using in the lectures. They are also colleagues working in research
in this area of anti-microbial resistance. And if you're curious to know about what
we normally do in our research laboratory, we do definitely research on predicting
and preventing infectious diseases and including anti microbial
resistance of course. And we do a lot of work on
supporting global surveillance. to help establishing and monitoring surveillance in
different countries in the world. As part of of this work we
are also reference laboratory for antimicrobial resistance in the EU for
the EU Comission. And we are the collaborating center for antimicrobial resistance
in
the World Health Organization. And therefore, we do a lot of work with
the countries to provide them with the methods and the teaching and
training of resistance testing methods. And finding out ways to get
comparable results between countries. We also do other teaching. We do teaching at
the Technical University of Denmark and training courses all
over the world basically. So in regards to the course, I'm sure you are curious to
know
what you will expect in the course. There will be six modules that will guide you
through starting with
antimicrobials and antimicrobial action. How drugs will affect bacteria. And then
we will go into the bacteria and
how they develop resistance, and how you do the tests. And we will look also into
the quality of those tests. How to do them well and finally we'll have a module on
looking directly at the genomes and finding the resistance mechanisms instead
of doing the susceptibility tests. So for these six modules you will have
a number of videos and each one of the modules and inside these videos to
keep you awake, to keep you on your feet we have some in video quizzes that you
will take in the middle of the videos. And in the final end of the modules, you
will have quizzes that will be
graded as part of your final grade. So you'll have six quizzes to put
together on your final grades. So, as part of what you expected to learn
in this course, well here you can see on the left side what the learning objectives
on pedagogic language would look like. But I'll make a translation for you. So as
the first part of the learning
objectives we would think that you learn things about what are the drugs,
what are the antimicrobials. So these antibiotics that you take and that you would
expect to kill or
inhibit bacteria, how do they act? And you will hear a lot about which
groups and how they act on bacteria then we have the bacterial side because
they would normally be killed or inhibited but
sometimes they develop resistance. So they get these special super power where they
can actually
resist to the anti-microbes. And that is quite interesting and we
are going to focus on how they manage to do that, how they manage to be a step
ahead of the pharmaceutical industry, and go and
get resistance against antimicrobials. And in that way, they become the superbugs
that you'll learn sometimes in the news. And we will also get a little bit
into how they become these superbugs, and how they manage to spread around
in the environment, and in animals, and in humans. So with all this we hope that as
part of this learning, you will get to understand a lot more of the scary
things that are put on the newspapers, or on the TV news about antimicrobial
resistance showing up in a unknown, bacteria that has an unknown
resistance mechanism in a far country. How will that affect me? That is something
that you might learn,
for example, taking the recent news in last November 2015 16 or sorry 15. There was
this new resistance
coming up for Colostin in China. And every newspaper in
the world was talking about it. But they we're not really
translating how does that affect me. So having this course you might have
a little bit more of an idea of what it really means to you in the end. So going a
little bit ahead on what you're
also expected to learn in this course, you'll learn a lot about testing. And this
is regarding
the methods that can be used, you will get presented the methods we
are going to explain what they are, how they are done, how you would go about
them, and what you get out of them. What is the difference so
that you can make a choice in case you need to make a choice in
choosing a method for a different purpose. And how in the end you will also make
sense of the results because then we have a module on interpretation of the
results depending on the method you get, you will get results and
you need to make sure that your results are interpreted in the best way so that
you can use them in different settings. So, as part of this getting the results
well and getting the results to be interpreted, you also need to
make sure that there are really right. And that's all about
quality management and quality assurance and
we'll have a few lectures on that. Looking at what is it that you can
do in a laboratory to make sure tha the results you get can be compared
with results in other parts of the world. And that they are right, and nobody can
tell you that they are not so right. So, that is about the testing in
phenotypes, in the laboratory. But, then we have another module
where we've turned the things around. So, now a days we have a whole
genome sequencing of bacteria. Why not look directly into
the DNA sequences and look for the resistance mechanism. Well that can also be
done. So in this course you also get
an introduction to some very easy tools on how to look into the genomes and
find these resistance mechanisms. And on finding them then you are almost
sure that the resistance is there and that they are what you aim to do,
to look at. We are not only going to present
you a tool on resistance. We are also going to present you another
tool where you can play with and put your own of interest. And, I think that is
very interesting for
many researchers around the world. And these videos are quite
demonstrative so that you can do it yourself when
you're ready with this course. So for learning objectives of
this course that is mostly it. But today we have other information
that might be interesting for you. If you're still in doubt, if you choose
this course or not we would like to tell you well that of course it is
a microbiology oriented course and knowing some basics about
microbiology might be an advantage. But it's actually not needed as much
because we are going to put the language so that anyone can understand. Also
regarding how things are going. We are going to do video lectures and
most of the materials are there. If we need to provide
you with something else. We will give you some links and
extra material but you will not need a course book or
such a purchase for this course. So you can go along without
buying any materials. Also, regarding the experience
that you have in the course, it's quite important that you feel
like you have somebody to talk to. And I would really recommend that
people going on our courses go on the discussion forums, present
yourself, start asking questions, so that it is a lively environment to exchange
ideas, and comments, and information. We've on behalf of the course team
we would really welcome you, and we hope you really enjoy this course, and
that you feel that you learned from it. Thank you very much. [MUSIC]

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Hello everyone.

Welcome to the course on Antimicrobial

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