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    Presented By: Imran Ahammad Chowdhury

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    Sonia Barua
    A loading dose is an initial higher dose of a drug given at the beginning of treatment to more rapidly reach steady state plasma concentrations. Drugs with long half-lives especially benefit from loading doses. The loading dose approximates the amount of drug in the body at steady state. It is calculated based on factors like the drug's half-life, desired plasma concentration, salt form, and bioavailability. The main importance of a loading dose is to quickly attain the average plasma concentration and therapeutic effects at steady state.

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    Presented By: Imran Ahammad Chowdhury

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    Sonia Barua
    215 views8 pages
    A loading dose is an initial higher dose of a drug given at the beginning of treatment to more rapidly reach steady state plasma concentrations. Drugs with long half-lives especially benefit from loading doses. The loading dose approximates the amount of drug in the body at steady state. It is calculated based on factors like the drug's half-life, desired plasma concentration, salt form, and bioavailability. The main importance of a loading dose is to quickly attain the average plasma concentration and therapeutic effects at steady state.

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    A loading dose is an initial higher dose of a drug given at the beginning of treatment to more rapidly reach steady state plasma concentrations. Drugs with long half-lives especially benefit from loading doses. The loading dose approximates the amount of drug in the body at steady state. It is calculated based on factors like the drug's half-life, desired plasma concentration, salt form, and bioavailability. The main importance of a loading dose is to quickly attain the average plasma concentration and therapeutic effects at steady state.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    215 views8 pages

    Presented By: Imran Ahammad Chowdhury

    Uploaded by

    Sonia Barua
    A loading dose is an initial higher dose of a drug given at the beginning of treatment to more rapidly reach steady state plasma concentrations. Drugs with long half-lives especially benefit from loading doses. The loading dose approximates the amount of drug in the body at steady state. It is calculated based on factors like the drug's half-life, desired plasma concentration, salt form, and bioavailability. The main importance of a loading dose is to quickly attain the average plasma concentration and therapeutic effects at steady state.

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    Presented by:

    Imran Ahammad Chowdhury


    LOADING DOSE
    A loading dose is an initial
    higher dose of a drug that may be
    given at the beginning of a course
    of treatment before dropping
    down to a lower maintenance
    dose.
    Drugs with long half-life require a loading
    dose to more rapid attain steady state plasma
    concentration. It is clinically desirable to
    achieve rapid therapeutic drug levels by using
    a loading dose.
    If a rapid dose is given too rapidly, the drug
    may initially give excessive high
    concentration in the plasma (central
    concentration), which then decrease as drug
    equilibrium reached.
    CALCULATION:

    The time required for the drug to accumulate to a steady-state


    plasma level is dependent mainly on its elimination half-life.
    The time needed to reach 90% of C ∞ av is approximately 3.3
    half-lives, and the time required to reach 99% of C ∞ av is equal
    to approximately 6.6 half-lives. For a drug with a half-life of 4
    hours, it will take approximately 13 and 26 hours to reach 90%
    and 99% of C ∞ av, respectively.

    For drugs absorbed rapidly in relation to elimination


    (k a >> k) and are distributed rapidly, the loading
    dose D L can be calculated as follows:
    For extremely rapid absorption, as when the product of k a is
    large or in the case of IV infusion, e –k a becomes approximately
    zero and 1st equation reduces to :

    The loading dose should approximate the amount of drug contained in the body at
    steady state. The dose ratio is equal to the loading dose divided by the maintenance
    dose.

    As a general rule, the dose ratio should be equal to 2.0 if the selected
    dosage interval is equal to the elimination half-life. shows the plasma level–
    time curve for dosage regimens with equal maintenance doses but different
    loading doses. A rapid approximation of loading dose, D L, may be
    estimated from:

    Where, C ∞ av is the desired plasma drug concentration, S is the salt form


    of the drug, and F is the fraction of drug bioavailability
    IMPORTANCE OF LOADING
    DOSE

    1. To attend quick plasma level.


    2. Attain quick action.
    3. The main importance of loading dose is
    average plasma concentration at steady state as
    quickly as possible.
    4. In some cases loading dose helps to get
    therapeutic effect quickly.
    THANK YOU

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