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    Hyperlipidemic Animal Models: Hyperlipidemia Induction Animal Specificity Modelsystem Effect Ref

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    Awais Arain Ahmad
    This document summarizes 8 different animal models that have been used to study hyperlipidemia. These include models using chickens, rabbits, rats, guinea pigs, quails, and hamsters fed various high fat or high cholesterol diets to induce hyperlipidemia. The models have been used to study the effects of drugs like quercetin on hyperlipidemia and conditions like atherosclerosis. Comparison of models found that guinea pigs are more sensitive to high fat diets than rats and can be used to study hyperlipidemia at low cholesterol levels. Quail were also identified as a useful model for atherosclerosis studies.

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    Hyperlipidemic Animal Models: Hyperlipidemia Induction Animal Specificity Modelsystem Effect Ref

    Uploaded by

    Awais Arain Ahmad
    23 views2 pages
    This document summarizes 8 different animal models that have been used to study hyperlipidemia. These include models using chickens, rabbits, rats, guinea pigs, quails, and hamsters fed various high fat or high cholesterol diets to induce hyperlipidemia. The models have been used to study the effects of drugs like quercetin on hyperlipidemia and conditions like atherosclerosis. Comparison of models found that guinea pigs are more sensitive to high fat diets than rats and can be used to study hyperlipidemia at low cholesterol levels. Quail were also identified as a useful model for atherosclerosis studies.

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    Hyperlipidemia Induction

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    This document summarizes 8 different animal models that have been used to study hyperlipidemia. These include models using chickens, rabbits, rats, guinea pigs, quails, and hamsters fed various high fat or high cholesterol diets to induce hyperlipidemia. The models have been used to study the effects of drugs like quercetin on hyperlipidemia and conditions like atherosclerosis. Comparison of models found that guinea pigs are more sensitive to high fat diets than rats and can be used to study hyperlipidemia at low cholesterol levels. Quail were also identified as a useful model for atherosclerosis studies.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    23 views2 pages

    Hyperlipidemic Animal Models: Hyperlipidemia Induction Animal Specificity Modelsystem Effect Ref

    Uploaded by

    Awais Arain Ahmad
    This document summarizes 8 different animal models that have been used to study hyperlipidemia. These include models using chickens, rabbits, rats, guinea pigs, quails, and hamsters fed various high fat or high cholesterol diets to induce hyperlipidemia. The models have been used to study the effects of drugs like quercetin on hyperlipidemia and conditions like atherosclerosis. Comparison of models found that guinea pigs are more sensitive to high fat diets than rats and can be used to study hyperlipidemia at low cholesterol levels. Quail were also identified as a useful model for atherosclerosis studies.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    of 2

    Hyperlipidemia Induction Animal ModelSystem Effect Ref.

    specificity
    Chicken lipid + sucrose BALB/c In vivo lipid and sucrose supplementation can induce [1]
    C57BL/J6 mice chronic hyperlipidemia as well as obesity
    HFD + Quercetin(drug) Male mongrel In vivo Quercetin acts as hypolipidemic by ameliorating [2]
    rabbit atherosclerosis
    HFD(2%cholestrol,10%lard,10% Sprague- In vivo Animala were more prone to the development of [3]
    Powdered egg yolk,0.2% bile salt) Dawley(SD) rats hyperlipidemia
    Coconut oil+castoroil+high Albino rats In vivo High fat diet and hypercholesteromlemia are [4]
    cholesterol diet considered as a risk of hepatic
    fibrosis,artheroscleoris and coronary artery disease.
    Poloxamer 407 Albino rats In vivo Poloxamer 407 cause dose dependent [5]
    hyperlipidemia by inhibiting activity of (LDL)
    Cholestrol + butter Male golden In vivo Hypercholesterolemia is one of the major risk factor [6]
    Syrian hamster for atherosclerosis.
    HFD(1% cholesterol) + LFD (0.1% Guinea pigs + In vivo Comparison was evaluated/ Guinea pigs are more [7]
    choletsrol) rat models sensitive to HFD than rat models.so for low
    cholesterol level guinea pigs can be use for
    hyperlipidemia study.
    Dietary cholesterol Quail In vivo Quail is a useful animal model for the study of [8]
    atherosclerosis.
    Hyperlipidemic Animal Models

    1. Madariaga, Y.G., et al., Assessment of four experimental models of hyperlipidemia. Lab Anim (NY), 2015. 44(4): p. 135-40.
    2. JuŸwiak, S., et al., Effect of quercetin on experimental hyperlipidemia and atherosclerosis in rabbits. Pharmacol Rep, 2005. 57(57): p.
    604-9.
    3. Xian, Z., et al., The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo. Biological and Pharmaceutical Bulletin,
    2017. 40(11): p. 1839-1845.
    4. Mathur, M. and K. Devi Vemula, Investigation of different types of nano drug delivery systems of atorvastatin for the treatment of
    hyperlipidemia. Drug development and industrial pharmacy, 2018. 44(12): p. 2048-2060.
    5. Sheneni, V., et al., Invivo biological effect of Carica papaya leaf extracts on P-407 induced hyperlipidemic Wistar rats. MOJ Food
    Process Technol, 2018. 6(4): p. 409-412.
    6. Nistor, A., et al., The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis, 1987. 68(1-2): p. 159-173.
    7. LI, J.-l., N.-n. GAO, and R.-m. YANG, Establishment and Mechanisms of a Guinea Pig Model of Hyperlipidemia and Comparison with
    the Rat Model [J]. Acta Laboratorium Animalis Scientia Sinica, 2009. 2.
    8. INOUE, Y., et al., The response of serum and hepatic lipids and the aortic wall to different levels of dietary cholesterol: a comparative
    study between hyperlipidemia-and-atherosclerosis-prone quail and commercially available quail. The Tohoku journal of experimental
    medicine, 1995. 175(1): p. 1-13.

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