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Discussion

Lipids are compounds that are insoluble in water but are soluble in


organic solvents such as ether and chloroform. Lipids that are important
to our discussion include fats and oils (triglycerides or triacyglycerols),
fatty acids, phospholipids, and cholesterol.
Fats and oils are esters of glycerol and three fatty acids. They are
important in the diet as energy sources and as sources of essential fatty
acids and fat-soluble vitamins, which tend to associate with fats. They
also contribute satiety, flavor, and palatability to the diet.
Linoleic acid (18 carbons with 2 double bonds) and arachidonic acid (20
carbons with 4 double bonds) belong to the omega(ω)-6 group of fatty
acids, since the first double bond, counting from the methyl end of the
molecule, occurs at carbon number 6. Since linoleic acid has 18 carbon
atoms and 2 double bonds, it is usually represented in shorthand as
C18:2, ω-6. Under this classification system, oleic acid (C18:1, ω-9)
belongs to the ω-9 group, and the PUFAs in fish oils currently receiving
much attention belong to the ω-3 group. Chief among these ω-3 fatty
acids are eicosapentaenoic acid (EPA), which has 20 carbons and 5
double bonds (C20:5, ω-3), and docosahexaenoic acid (DHA), which
has 22 carbons and 6 double bonds (C22:6, ω-3).

A growing body of evidence from studies in animals, including


nonhuman primates, indicates that α-linolenic acid, or its longer-chain
derivates EPA and DHA, are essential in the diet. These fatty acids
appear to play distinctive roles in the structure and function of biologic
membranes in the retina and central nervous system (Neuringer and
Connor, 1986).
Phospholipids contain glycerol, fatty acids, phosphate, and, with such
exceptions as phosphatidylglycerol and phosphatidylinositol, a
nitrogenous component. Lecithin, for example, is made up of glycerol,
two fatty acids (one saturated, usually), phosphate, and choline.
Phospholipids are important structural components of brain and nervous
tissue, of membranes throughout body tissues, and of lipoproteins—the
carriers of cholesterol and fats in the blood.
Cholesterol and plant sterols, such as sitosterol, are high-molecular-
weight alcohols with a characteristic cyclic nucleus and are unrelated to
the structure of fats or phospholipids. Cholesterol frequently exists in
foods and body tissues esterified to one fatty acid per molecule. It is a
component of membranes in body cells and is required for normal
development of the brain and nervous tissue. Furthermore, it is the
precursor to bile acids, steroid hormones, and 7-dehydrocholesterol in
the skin, which in turn is the precursor to vitamin D.
Cholesterol occurs naturally only in foods of animal origin. The highest
concentrations are found in liver and egg yolk, but red meats, poultry
(especially the skin), whole milk, and cheese make significant
contributions to the diet

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