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    CC1 8

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    Joshua Trinidad
    The document contains 10 multiple choice questions about clinical chemistry concepts such as Gaussian distributions, mean, median, standard deviation, method comparison studies, systematic error, reference intervals, and reference interval verification. For each question, the document provides an explanation or rationale for the correct answer. It defines key terms and concepts and applies mathematical formulas as needed to justify the reasoning behind selecting the right choice.

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    CC1 8

    Uploaded by

    Joshua Trinidad
    117 views4 pages
    The document contains 10 multiple choice questions about clinical chemistry concepts such as Gaussian distributions, mean, median, standard deviation, method comparison studies, systematic error, reference intervals, and reference interval verification. For each question, the document provides an explanation or rationale for the correct answer. It defines key terms and concepts and applies mathematical formulas as needed to justify the reasoning behind selecting the right choice.

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    The document contains 10 multiple choice questions about clinical chemistry concepts such as Gaussian distributions, mean, median, standard deviation, method comparison studies, systematic error, reference intervals, and reference interval verification. For each question, the document provides an explanation or rationale for the correct answer. It defines key terms and concepts and applies mathematical formulas as needed to justify the reasoning behind selecting the right choice.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    117 views4 pages

    CC1 8

    Uploaded by

    Joshua Trinidad
    The document contains 10 multiple choice questions about clinical chemistry concepts such as Gaussian distributions, mean, median, standard deviation, method comparison studies, systematic error, reference intervals, and reference interval verification. For each question, the document provides an explanation or rationale for the correct answer. It defines key terms and concepts and applies mathematical formulas as needed to justify the reasoning behind selecting the right choice.

    Copyright:

    © All Rights Reserved
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    Download as doc, pdf, or txt
    of 4

    Answer and Rationalize

    1. A Gaussian distribution is usually


    a. Bell-shaped
    b. Rectangular
    c. Uniform
    d. Skewed
    *defined formally as a normalized frequency distribution that is symmetrical about the
    line of zero error and in which the frequency and magnitude of quantities are related by
    the expression

    2. The following chloride (mmol/L) results were obtained using a new analyzer: 106 111
    104 106 112 110 115 127 83 110 108 109 83 119 105 106 108 114 120 100 107 110 109
    102
    What is the mean?
    a. 108
    b. 105
    c. 109
    d. 107
    *All the sample given will be added, resulting to 2584 then divided into 24 because they
    are 24 sets of given. It will give you 107.67 or 108.

    3. The following chloride (mmol/L) results were obtained using a new analyzer: 106 111
    104 106 112 110 115 127 83 110 108 109 83 119 105 106 108 114 120 100 107 110 109
    102
    What is the median?
    a. 108.5
    b. 105
    c. 112
    d. 107
    *Those sample given must be in order from lowest to biggest. Each end must be equal
    and when looking in the middle, make sure that it is only one. If not, add those two given
    sample and divide it into 2. And there, you have it.
    4. For a data value set that is Gaussian distributed, what is the likelihood (%) that a data
    point will be within ±1 SD from the mean?
    a. 68%
    b. 99%
    c. 95%
    d. 100%
    *For the standard normal distribution, 68% of the observations lie within 1 standard
    deviation of the mean; 95% lie within two standard deviation of the mean; and 99.9% lie
    within 3 standard deviations of the mean.

    5. The correlation coefficient


    a. Indicates the strength of relationship in a linear regression.
    b. Determines the regression type used to derive the slope and y-intercept.
    c. Is always expressed as “b.”
    d. Expresses method imprecision
    *The magnitude of the correlation coefficient indicates the strength of the association.

    6. If two methods agree perfectly in a method comparison study, the slope equals _____
    and the y-intercept equals _____.
    a. 1.0, 0.0
    b. 0.0, 1.0
    c. 1.0, 1.0
    d. 0.0, 0.0
    e. 0.5, 0.5
    *to make sure that there is a difference between the first method to another method.
    7. Systematic error can best be described as consisting of
    a. Constant and proportional error.
    b. Constant error.
    c. Proportional error.
    d. Random error.
    e. Syntax error.
    *because when we say proportional, it is corresponding in size or amount to something
    else and by that, we can see the problem immediately,

    8. Examples of typical reference interval data distribution plots include all of the
    following except
    a. ROC
    b. Nonparametric
    c. Parametric
    d. Bimodal
    * Receiver Operating Characteristic is created by plotting the true positive rate against the
    false positive rate at various threshold settings. Also, it is a graphical plot that illustrates
    the diagnostic ability of a binary classifier system as its discrimination threshold is
    varied. while the nonparametric, parametric, and bimodal are only focusing on the peaks
    of the distribution.

    9. A reference range can be verified by


    a. Testing as few as 20 normal donor specimens.
    b. Literature and vendor material review.
    c. Using samples from previously tested hospital patients.
    d. Using pharmacy-provided plasmanate spiked with target analyte concentrations.
    *The more the merrier, that’s why it should be more than the expected donor to be able to
    gather more information.
    10. Reference interval transference studies
    a. Are used to verify a reference interval.
    b. Are used to establish a reference interval.
    c. Require as many as 120 normal donors.
    d. Use a 68% reference limit for acceptability.

    *Reference interval is the range of values that is deemed normal for a physiologic
    measurement in healthy persons.

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