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    V. Azapirones

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    Christine Pialan Salimbagat
    This document provides information on the azapirone buspirone, including its classification, dosage, mechanism of action, drug interactions, indications, contraindications, side effects, and nursing responsibilities. Buspirone is an anxiolytic that works by binding serotonin and dopamine receptors in the brain. It is administered orally twice daily and has drug interactions with MAO inhibitors and grapefruit juice. Common side effects include dizziness, nausea, and headache. Nurses should assess anxiety levels before and during therapy and educate patients on proper administration and reporting side effects.

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    V. Azapirones

    Uploaded by

    Christine Pialan Salimbagat
    71 views2 pages
    This document provides information on the azapirone buspirone, including its classification, dosage, mechanism of action, drug interactions, indications, contraindications, side effects, and nursing responsibilities. Buspirone is an anxiolytic that works by binding serotonin and dopamine receptors in the brain. It is administered orally twice daily and has drug interactions with MAO inhibitors and grapefruit juice. Common side effects include dizziness, nausea, and headache. Nurses should assess anxiety levels before and during therapy and educate patients on proper administration and reporting side effects.

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    This document provides information on the azapirone buspirone, including its classification, dosage, mechanism of action, drug interactions, indications, contraindications, side effects, and nursing responsibilities. Buspirone is an anxiolytic that works by binding serotonin and dopamine receptors in the brain. It is administered orally twice daily and has drug interactions with MAO inhibitors and grapefruit juice. Common side effects include dizziness, nausea, and headache. Nurses should assess anxiety levels before and during therapy and educate patients on proper administration and reporting side effects.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    71 views2 pages

    V. Azapirones

    Uploaded by

    Christine Pialan Salimbagat
    This document provides information on the azapirone buspirone, including its classification, dosage, mechanism of action, drug interactions, indications, contraindications, side effects, and nursing responsibilities. Buspirone is an anxiolytic that works by binding serotonin and dopamine receptors in the brain. It is administered orally twice daily and has drug interactions with MAO inhibitors and grapefruit juice. Common side effects include dizziness, nausea, and headache. Nurses should assess anxiety levels before and during therapy and educate patients on proper administration and reporting side effects.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Brand Name:

    Generic Name:

    Classification: AZAPIRONES

    Recommended Dosage, Route, and Frequency:

    PO (Adults): 7.5 mg twice daily;qby 5 mg/day q 2– 4 days as needed (not to exceed 60 mg/day). Usual
    dose is 20– 30 mg/day (in 2 divided doses).

    Drug Action: ADME, Onset, Peak, Duration

    Binds to serotonin and dopamine receptors in the brain. Increases norepinephrine metabolism in the
    brain. Therapeutic Effects: Relief of anxiety
    Absorption: Rapidly absorbed. Distribution: Unknown
    Metabolism and Excretion: Extensively metabolized by the liver (CYP3A4 enzyme system); 20– 40%
    excreted in feces.

    Drug-Drug and Drug-Food Interactions:

    Drug-Drug: Use with MAO inhibitors may result in hypertension and is not recommended
    Drug-Natural Products: Concomitant use of kava-kava,valerian, orchamomile can↑CNS depression.
    Drug-Food: Grapefruit juice ↑ serum levels and effect; ingestion of large amounts of grapefruit juice is
    not recommended.

    Indications:
    Management of anxiety.

    Contraindications:

    Contraindicated in: Hypersensitivity; Severe hepatic or renal impairment; Concurrent use of MAO
    inhibitors; Ingestion of large amounts of grapefruit juice. Use Cautiously in: Patients receiving other
    antianxiety agents (other agents should be slowly withdrawn to prevent withdrawal or rebound
    phenomenon); Patients receiving other psychotropics;

    Side Effects: By system

    CNS: dizziness, drowsiness, excitement, fatigue, headache, insomnia, nervousness EENT: blurred vision,
    sore throat GI: nausea, abdominal pain, constipation, diarrhea, dry mouth, vomiting

    Adverse Reaction: By system

    CNS: dizziness, drowsiness, excitement, fatigue, headache, insomnia, nervousness, weakness,


    personality changes. EENT: blurred vision, nasal congestion, sore throat, tinnitus, altered taste or smell,
    conjunctivitis. Resp: chest congestion, hyperventilation, shortness of breath. CV:chest pain, palpitations,
    tachycardia, hypertension, hypotension, syncope. GI: nausea, abdominal pain, constipation, diarrhea,
    dry mouth, vomiting. GU: changes in libido, dysuria, urinary frequency, urinary hesitancy. Derm: rashes,
    alopecia, blisters, dry skin, easy bruising, edema, flushing, pruritus. Endo: irregular menses. MS: myalgia.
    Neuro: incoordination, numbness, paresthesia, tremor.Misc:clamminess, sweating, fever.

    Nursing Responsibilities: (ADPIE Format)

    Assessment
    ● Assess degree and manifestations of anxiety before and periodically during therapy. ● Buspirone does
    not appear to cause physical or psychological dependence or tolerance. However, patients with a history
    of substance use disorder should be assessed for tolerance or impaired control. Restrict amount of drug
    available to these patients.

    Potential Nursing Diagnoses

    Anxiety (Indications)
    Risk for injury (Side Effects)

    Implementation
    ● Do not confuse buspirone with bupropion. ● Patients changing from other antianxiety agents should
    receive gradually decreasing doses. Buspirone will not prevent withdrawal symptoms. ● PO: May be
    administered with food to minimize gastric irritation. Food slows but does not alter extent of
    absorption.

    Patient/Family Teaching
    Instruct patient to notify health care professional if any chronic abnormal movements occur (dystonia,
    motor restlessness, involuntary movements of facial or cervical muscles) or if pregnancy is suspected.

    Evaluation/Desired Outcomes
    ● Increase in sense of well-being. ● Decrease in subjective feelings of anxiety. Some improvement may
    be seen in 7– 10 days. Optimal results take 3– 4 wk of therapy. Buspirone is usually used for short-term
    therapy (3– 4 wk). If prescribed for long-term therapy, efficacy should be periodically assessed.

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