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    Paracetamol Overdose: BW 40 KG Without Fluid Restriction

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    Andy Tan
    This document outlines the SGH protocol for administering N-acetylcysteine (NAC) intravenous therapy to patients for paracetamol overdose and acute liver failure. It provides dosage guidelines based on patient weight, with higher dosages given over shorter durations initially then lower dosages over longer durations. Guidelines are given for patients both above and below 40kg in weight and/or with fluid restrictions.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Paracetamol Overdose: BW 40 KG Without Fluid Restriction

    Uploaded by

    Andy Tan
    223 views2 pages
    This document outlines the SGH protocol for administering N-acetylcysteine (NAC) intravenous therapy to patients for paracetamol overdose and acute liver failure. It provides dosage guidelines based on patient weight, with higher dosages given over shorter durations initially then lower dosages over longer durations. Guidelines are given for patients both above and below 40kg in weight and/or with fluid restrictions.

    Original Description:

    Acetylcysteine infusion protocol for acute liver failure and pcm toxicity

    Original Title

    SGH Protocol for NAC

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    This document outlines the SGH protocol for administering N-acetylcysteine (NAC) intravenous therapy to patients for paracetamol overdose and acute liver failure. It provides dosage guidelines based on patient weight, with higher dosages given over shorter durations initially then lower dosages over longer durations. Guidelines are given for patients both above and below 40kg in weight and/or with fluid restrictions.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    223 views2 pages

    Paracetamol Overdose: BW 40 KG Without Fluid Restriction

    Uploaded by

    Andy Tan
    This document outlines the SGH protocol for administering N-acetylcysteine (NAC) intravenous therapy to patients for paracetamol overdose and acute liver failure. It provides dosage guidelines based on patient weight, with higher dosages given over shorter durations initially then lower dosages over longer durations. Guidelines are given for patients both above and below 40kg in weight and/or with fluid restrictions.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    SGH Protocol for N-acetylcysteine (NAC) for paracetamol overdose and acute liver failure HUS1.

    1/ver1/2020

    Paracetamol Overdose
    Patient’s Actual body
    IC No:
    name: weight (kg):

    BW ≥ 40 kg without fluid restriction


    Start date
    IV NAC 200 mg/kg over 4 hours & time

    STEP 200 mg × _______ (kg) BW = ______________ (mg) NAC


    1
    Dilute in 500 ml D5% and infuse over 4 hours.
    Infusion rate:125 ml/hour (Signature)

    Start date
    IV NAC 50 mg/kg over 8 hours & time

    STEP 50 mg × _______ (kg) BW = _______________ (mg) NAC


    2
    Dilute in 500 ml D5% and infuse over 8 hours.
    (Signature)
    Infusion rate: 63 ml/hour
    Start date
    IV NAC 50 mg/kg over 8 hours & time

    STEP 50 mg × _______ (kg) BW = _______________ (mg) NAC


    3
    Dilute in 500 ml D5% and infuse over 8 hours.
    Infusion rate: 63 ml/hour (Signature)

    ××××××××××××××××××××××××××××××××××××××××××××
    BW < 40 kg and/or fluid restriction
    Start date
    IV NAC 200 mg/kg over 4 hours & time

    STEP 200 mg × _______ (kg) BW = _____________ (mg) NAC


    1
    Dilute in 250 ml D5% and infuse over 4 hours.
    (Signature)
    Infusion rate:125 ml/hour
    Start date
    IV NAC 100 mg/kg over 16 hours & time

    STEP 100 mg × _______ (kg) BW = ______________ (mg) NAC


    2-3
    Dilute in 500 ml D5% and infuse over 16 hours.
    (Signature)
    Infusion rate: 63 ml/hour
    NOTE: Alternative diluent: Normal Saline (NaCl 0.9%)
    Stability of diluted solution: 24 hours
    Strength of NAC available: 200 mg/ml

    Ordered by: Date:


    (Signature & stamp)

    Acute Liver Failure


    Page 1
    SGH Protocol for N-acetylcysteine (NAC) for paracetamol overdose and acute liver failure HUS1.1/ver1/2020
    Patient’s Actual body
    IC No:
    name: weight (kg):

    BW ≥ 40 kg without fluid restriction


    IV NAC 150 mg/kg over 1 hour (150 mg/kg/hour) Start date & time

    STEP
    1 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 200 ml D5% and infuse over 1 hour. Infusion rate: 200 ml/hour (Signature)

    IV NAC 50 mg/kg over 4 hours (12.5 mg/kg/hour) Start date & time

    STEP
    2 50 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 500 ml D5% and infuse over 4 hours. Infusion rate: 125 ml/hour (Signature)

    IV NAC 150 mg/kg over 24 hours (6.25 mg/kg/hour) Start date & time

    STEP
    3 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 500 ml D5% and infuse over 24 hours. Infusion rate: 21 ml/hour (Signature)

    IV NAC 150 mg/kg over 24 hours (6.25 mg/kg/hour) Start date & time

    STEP
    4 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 500 ml D5% and infuse over 24 hours. Infusion rate: 21 ml/hour (Signature)

    IV NAC 118.75 mg/kg over 19 hours (6.25 mg/kg/hour) Start date & time

    STEP
    5 118.75 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 500 ml D5% and infuse over 19 hours. Infusion rate: 21 ml/hour (Signature)

    ××××××××××××××××××××××××××××××××××××××××××××××××××××××××××××××××××××
    BW < 40 kg and/or fluid restriction
    IV NAC 150 mg/kg over 1 hour (150 mg/kg/hour) Start date & time

    STEP
    1 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 100 ml D5% and infuse over 1 hour. Infusion rate: 100 ml/hour (Signature)

    IV NAC 50 mg/kg over 4 hours (12.5 mg/kg/hour) Start date & time

    STEP
    2 50 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 250 ml D5% and infuse over 4 hours. Infusion rate: 63 ml/hour (Signature)

    IV NAC 150 mg/kg over 24 hours (6.25 mg/kg/hour) Start date & time

    STEP
    3 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 250 ml D5% and infuse over 24 hours. Infusion rate: 11 ml/hour (Signature)

    IV NAC 150 mg/kg over 24 hours (6.25 mg/kg/hour) Start date & time

    STEP
    4 150 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 250 ml D5% and infuse over 24 hours. Infusion rate: 11 ml/hour (Signature)

    IV NAC 118.75 mg/kg over 19 hours (6.25 mg/kg/hour) Start date & time

    STEP
    5 118.75 mg × _______ (kg) BW = ______________ (mg) NAC.
    Dilute in 250 ml D5% and infuse over 19 hours. Infusion rate: 11 ml/hour (Signature)

    Ordered by: Date:


    (Signature & stamp)

    Page 2

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