Comprehensive Assessment I:

I. Identification: (Refer to Appendix B of your textbook)

Liniment​ - Alcoholic or oleaginous solutions or emulsions of various medicinal substances intended to be

rubbed on the skin and to be used for treating stiffness of underlying musculature.
Collodion​ - Liquid preparations composed of pyroxylin dissolved in an alcohol-ether mixture with or
without added medicinal substances.
Tincture​ - Alcoholic or hydroalcoholic solution prepared from vegetable material or chemical substance.
Aromatic Water​ - Clear aqueous solutions saturated with volatile oils.
Aqueous or oleaginous solutions in the form of coarse droplets or as finely divided solids to be applied
topically, most usually to the nasopharyngeal tract or to the skin.
Spirit​ - Alcoholic or hydroalcoholic solutions of volatile substances prepared usually by simple solution.
Elixir ​- Clear, sweetened hydroalcoholic solutions intended for oral use and are usually flavored.
Concentrated aqueous preparations of a sugar or sugar substitute with or without flavoring agents and
medicinal substances.
Emulsion​ - A two-phase system in which one liquid is dispersed throughout another liquid in the form of
small droplets.
Extract​ - A concentrated preparation of vegetable or animal drug obtained by removal of the active
constituents with suitable menstrua by evaporation of all or nearly all of the solvent.
Fluidextract​ - A liquid preparation of a vegetable drug containing alcohol as a solvent, preservative, each
milliliter contains the therapeutic constituents of 1 g of the standard drug.
Foam ​- An emulsion containing dispersed gas bubbles.
Gel ​- A semisolid system consisting of either a suspension of small inorganic particles or large organic
molecules interpenetrated by a liquid.
Inhalant​ - Drug or combination of drugs that by virtue of their high vapor pressure can be caried by an air
current into the nasal passage where they exert their effect.
Sterile and pyrogen-free preparation intended for parenteral administration.
Solution​ - A liquid preparation that contains one or more dissolved chemical substances in a suitable
solvent or mixture of miscible solvents.
Suspension​ - A liquid preparation that consists of solid particles dispersed throughout a liquid phase in
which the particles are not soluble.
Douche​ - A liquid preparation intended for the irrigate cleansing of the vagina.
A gel mass consists of floccules of small, distinct particles and is classified as a two-phase system.
Irrigation​ - A sterile solution intended to bathe of flush open wounds or body cavities.
II. Transdermal Drug Delivery Systems

1. Transdermal drug delivery systems (TDDS)

I. Facilitate the passage if therapeutic quantities of drug substances through the skin into
the systemic circulation
II. Often called "transdermal patches"
III. Avoid first-pass effect
A. only I is correct B. I and III are correct
C. I and II are correct ​ ​D. I, II and III are correct
2.​ ​Transderm-Nitro Therapeutic System
I. Is an example of monolithic system – membrane-controlled
II. Is used to treat and prevent angina
III. Delivers nitroglycerin for 24 hours after application
A. only II is correct ​ ​B. II and III are correct
C. I and III are correct D. I, II and III are correct
3.​ ​ A TDDS used to prevent travel related motion sickness is:
A. Transdermal Scopolamine​ B. Transdermal Clonidine - hypertension
C. Transdermal Nicotine – adjuncts in smoking cessation programs D. Transdermal
Estradiol – treatment of moderate to severe vasomotor symptoms assoc. with
menopause-anything that has do to with the female reproductive system
4.​ ​Nicotine transdermal delivery system:
A. Testoderm - Testosterone B. Deponit - Nitroglycerin
C. Habitrol D. Transderm-Scop
5.​ ​Correct statement about Catapres TTs include:
I. The first transdermal patch to receive FDA approval – transdermal scopolamine
II. Worn in a hairless area behind the ear – upper outer arm or chest
III. Provides controlled release of clonidine for 7 days
A. I, II and III B. I and III
C. I and II D. III only
6.​ ​Drug readily absorbed in the skin and administered via transdermal route include:
I. Nitroglycerin II. Clonidine III. Scopolamine
A. Only I is correct B. I and III are correct
C. I and II are correct D. I, II and III are correct
7.​ ​Clinical considerations in the use of TDDS include:
I. Should be placed at a site that will subject it to being rubbed off by clothing or
movement – should not be
II. Wet or moist skin can accelerate drug permeation beyond the intended rate
III. Use of skin lotions should be avoided at the application site because they affect skin
hydration and can also alter the partition coefficient between the drug in the TDDS and
the skin
A. I only B. III only
C. I and III D. II and III
8.​ ​Which of the following is a correct statement regarding TDDS?
A. Ortho Evra is a testosterone transdermal system - contraceptive
B. Skin lotion may be used at the application site of transdermal patches to avoid
irritation
C. Physical exercise and extreme ambient temperature (e.g. sauna) may increase
the absorption of drug from nitroglycerin patch
D. Absorption of drug from TDDS is greater if the patch is applied to a site with a thick
horny layer
9.​ ​Considerations in the use of TDDS include:
I. Rotating locations within the recommended site should be avoided in the application of
replacement patches – rotate locations within the site
II. TDDS should be removed when showering, bathing or swimming – may be left on
III. Use of the skin lotions should be avoided at the application site because they affect
skin hydration and can also alter the partition coefficient between the drug in the TDDS
and the skin
A. I, II and III B. I and II
C. II and III D. III only
10.​ ​A part of a monolithic transdermal system that functions to store and release the drug at
the skin site is the:
A. Occlusive backing layer - protect the system from environmental entry and from loss
of drug from the system or moisture from the skin B. Liquid drug reservoir
C. Semi-permeable membrane D. Matrix system
11.​ ​ Membrane-controlled transdermal system contains the following layers:
I. An occlusive backing layer
II. Drug matrix system
III. Microporous rate-limiting membrane
A. Only III is correct ​ ​ ​ B. I and III are correct
C. II and III are correct D. I and II are correct
12.​ ​ The ideal molecular weight of a drug for transdermal drug delivery is:
A. 1000 and below B. 800 and below
C. 600 and below ​ ​D. 400 and below
13.​ ​ Advantages of transdermal drug delivery systems EXCEPT:
A. It can avoid gastrointestinal drug absorption difficulties
B. It avoids first pass effect
C. They are non-invasive
D. Only potent drugs are suitable candidates for transdermal delivery
14.​ ​The first transdermal system for hypertension:
A. Nicotine B. Clonidine
C. Nitroglycerin D. Estradiol
15.​ ​General guidelines for TDDS's EXCEPT:
A. It should be applied to clean, dry skin.
B. Use of skin lotion should be avoided at the application site.
C. It can be physically altered by cutting.
D. It may be left on when showering, bathing or swimming.
III. Suppositories, Sticks, and Inserts

1. Cocoa butter:
I. Exhibits marked polymorphism
II. Phenol and chloral hydrate have a tendency to lower its melting point
III. Is a water-soluble or water-miscible base – glycerinated gelatin and polyethylene
glycol
A. I only B. III only
C. I and II ​ ​ D. II and III
2.​ ​The following drug products require colorants EXCEPT:
A. Capsules B. Suspension
C. Sugar-coated tablets ​ ​D. Suppositories
3.​ ​In preparing vaginal inserts, the following excipients are used EXCEPT:
A. Lubricant B. Disintegrating agent
C. Filler ​D. Coating agent
4.​ ​Wecobee bases used in suppositories are triglycerides derived from:
A. Mineral oil​ ​ B. Coconut oil
C. Almond oil D. Theobroma oil
5.​ ​In preparing suppositories by molding from a melt, lubricating the mold is required if the
suppository is:
A. PEG-based B. Cocoa butter-based
C. Glycerinated gelatin based​ ​D. Both B and C
6.​ ​True statement about PEG-based suppositories include:
I. Stored at room temperature
II. Leaks from the orifice – does not leak
III. It dissolves in the body fluid to release the active drug
A. I, II and III ​ ​B. I and III
C. II and III D. I and II
7.​ ​Cocoa butter, NF is also known as:
A. Yellow wax B. Paraffin
C. Theobroma oil ​ ​D. Spermaceti
8.​ ​Suppositories that are shaped like a bullet, or torpedo or the little finger:
A. Rectal ​ ​B. Vaginal – globular, oviform, or cone shaped
C. Urethral – slender, pencil-shaped D. Nasal
9.​ ​Example of rectal suppositories:
A. Clindamycin phosphate – vagina; B. Clotrimazole
C. Miconazole nitrate - vaginal ​D. Bisacodyl
10.​ ​Suppositories that are usually globular, oviform, or cone-shaped and weigh about 5g
when cocoa butter is the base
A. Rectal ​ ​ B. Vaginal
C. Urethral D. Nasal
11.​ ​Solid dosage forms intended for insertion into the body orifices where they melt, soften or
dissolve and exert local or systemic effects.
A. Suppositories ​ ​B. Lozenges
C. Pills D. Emulsion
12.​ ​The most frequently employed suppository bases.
A. Water miscible bases B. Polyethylene glycols
C. Fatty bases ​ ​ D. Glycerin
13.​ ​Type of suppositories that are thinner and tapered, often about 5 mm in diameter.
A. Rectal ​ ​B. Urethral
C. Vaginal ​ ​D. Aural
14.​ ​Example of vaginal suppositories​:
A. Hydromorphone ​ ​ ​B. Clotrimazole
C. Hydrocortisone D. Bisacodyl
15.​ ​Cocoa butter is softened due to the addition of certain drugs, which of the following can
be added as a solidifying agent?
A. Gelatin B. White petrolatum
C. Paraffin ​ ​ D. Beeswax
Comprehensive Assessment II:
I. Solutions
1. A viscous liquid, miscible with water and alcohol frequently substituted for glycerin in modern
pharmaceutical formulations.
A. Isopropyl alcohol B. Purified water
C. Propylene glycol D. Glycerol
2. Process referred to in industry as cross-flow membrane filtration.
A. Ion exchange method B. reverse osmosis
C. cation exchange D. distillation
3. A normal physiologic body response to rid itself of a noxious or toxic substance, such as
rotavirus or Escherichia coli.
A. diarrhea B. vomitting
C. acidosis D. hypovolemic shock
4. Self-preserving elixir and do not require the addition of an antimicrobial agent.
A. 4% - 6% B. 6% - 8%
C. 8% -10% D. 10% -12%
5. Water soluble organic mercurial antibacterial agent used topically for its bacteriostatic and
mild fungistatic properties:
A. Hydrogen peroxide topical solution B. Povidone iodine topical solution
C. Thimerosal topical solution D. Chlorhexedine gluconate
6. Component of douche powder EXCEPT:
A. Boric acid B. Zinc sulfate
C. Sodium sulfate D. Detergent
7. Medical substances employed topically in the mouth.
A. Benzocaine B. Camphorated parachlorophenol
C. Carbamide peroxide D. all of the above
8. When the word alcohol is used in pharmacy, it refers especially to:
A. isopropyl alcohol B. ethanol-water mixture 50% v/v
C. ethyl alcohol D. methyl alcohol
9. Purified water USP:
I. Can be prepared by ion-exchange treatment
II. Used to manufacture parenterals
III. Sterile and pyrogen free
A. I, II and III B. I and II
C. only I is correct D. II and III
10. Use of aromatic waters:
I. Flavored vehicle
II. Perfumed vehicle
III. Disinfectant
A. I, II and III B. I and II
C. II and III D. I and III
11. The following solutions are administered topically EXCEPT:
A. Hydrogen peroxide solution B. Aluminum subacetate solution
C. Povidone-iodine solution D. Magnesium Citrate solution
12. Which of the following statements is correct about Simple Syrup?
I. It is a highly viscous vehicle
II. It is 85%w/w
III. A sucrose-based syrup
A. I, II and III B. I and III
C. II and III D. only III is correct
13. Medicated syrups have 3 or more components. Which of the following could be present?
I. A pharmacologically active chemical
II. Sucrose or artificial sweeteners
III. Flavoring agents
A. I only B. II and III
C. I and III D. I, II and III
14. Dilute acids have strength of:
A. 10%w/w B. 10%w/v
C. 12%w/v D. 6%w/w
15. Evacuation enemas are used to:
I. Promote evacuation of bowel
II. Cleanse the colon
III. Diagnose the GIT
A. I and III B. I and II
C. II and III D. I, II and III
16. Compared with syrups, elixirs are:
I. Less sweet
II. Less effective in masking the taste of medicinal substances
III. More viscous
A. I, II and III B. II and III
C. I and II D. I and III
17. Phenobarbital Elixir is used as:
A. cardiotonic B. nasal decongestant
C. antihistamine D. sedative-hypnotic
18. Spirits can be prepared by:
I. Solution with heat
II. Solution with maceration
III. Distillation
A. I, II and III B. II and III
C. I and II D. only III is correct
19. Flexible Collodion is prepared by adding castor oil and camphor to Collodion USP. How
many % castor oil is required in this preparation?
A. 1% B. 2%
C. 3% D. 5%
20. The method of extraction is a process in which the soluble constituent of a comminuted drug
is extracted by a slow passage of a suitable solvent through a column of the drug.
A. percolation B. infusion
C. decoction D. maceration
 II. Dispersed Systems:
1. Reasons for preparing suspensions EXCEPT:
A. Drugs are chemically unstable in solution. B. ease of swallowing
C. used to prepare a palatable liquid dosage form​ D. none of the above
2. The study of flow which addresses the viscosity characteristics of powder, fluids and
semisolids.
A. Stokes B. Colligative
C. Embryology D. Rheology
3. Guidelines in packaging and storage of suspensions EXCEPT:
A. Use wide mouth container B. protected from freezing
C. tight container D. clear bottle
4. Method which is useful for the extemporaneous preparation of emulsions from volatile oils or
oleaginous substances of low viscosities.
A. Forbes bottle method B. English method
C. Dry gum method D. Auxiliary method
5. Semisolid systems consisting of dispersion made up of either small inorganic particles or
large organic molecules enclosing and interpenetrated by a liquid.
A. suspension B. gels
C. emulsion D. collodion
6. The taking up of a certain amount of liquid without a measurable increase in volume.
A. Imbibition B. Swelling
C. Syneresis D. Thixotropy
7. Taking up of liquid by a gel with an increase in volume.
A. Imbibition B. Swelling
C. Syneresis D. Thixotropy
8. It occurs when the interaction between particles of the dispersed phase becomes so great
that on standing, the dispersing medium is squeezed out in droplets and the gel shrinks.
A. Imbibition B. Swelling
C. Syneresis D. Thixotropy
9. A reversible gel sol with no change in volume or temperature.
A. Imbibition B. Swelling
C. Syneresis D. Thixotropy
10. It is formed when the liquid is removed from a gel and only the framework remains.
A. suspension B. emulsion
C. xerogel D. solution
11. Example/s of gelling agent.
A. Acacia B. Alginic acid
C. Bentonite D. all of the above
12. It is not a component of an aerosol formulation.
A. Product concentrate B. propellant
C. housing D. active ingredient
13. Part of the usual aerosol valve assembly that supports the actuator and delivers the
formulation in the proper form to the chamber of actuator.
A. stem B. gasket
C. spring D. mounting cup
14. Temperature necessary to liquefy the propellant gas in aerosol.
A. 0⁰C and below B. -15⁰C to -20⁰C
C. -25.5⁰C to -30⁰C D. -34.5⁰C to -40⁰C
15. Acacia, as ___% dispersion in water, is used as a suspending agent.
A. 10 B. 25
C. 35 D. 50
16. Benzalkonium chloride is :
A. non-ionic surfactant B. cationic surfactant
C. anionic surfactant D. chelating agent
17. The theory of emulsification assumes monomolecular layers of emulsifying agent curved
around a droplet of the internal phase.
A. Surface tension B. Plastic-film
C. Oriented-wedge D. Interfacial film
18. Inhalation aerosols are commonly employed as/in:
A. anti-infective B. contraceptive
C. anorectal conditions D. asthma therapy
19. Which of the following have liquid as a continuous phase?
I. Emulsions
II. Aerosols
III. Suspensions
A. I, II and III B. II and III
C. I and III D. only III

20. Microemulsions are:

I. Thermodynamically unstable system
II. Optically transparent
III. O/W system stabilized by surfactant
A. I, II and III B. II and III
C. I and II D. only I
III. Parenterals
1. Aqueous vehicle for parenteral products include:
I. Water for injection
II. Bacteriostatic water for injection
III. Sodium chloride injection
A. I, II and III B. II and III
C. I and III D. I and II
2. Large volume parenterals for maintenance therapy is employed for patients:
I. Entering or recovering from surgery
II. Who are unconscious and unstable to take fluids, electrolytes and nutrition orally
III. Who have suffered a heavy loss of fluids and electrolytes such as diarrhea
A. I, II and III B. I and II
C. I only D. II and III
3. Propofol USP is a:
A. solution for injection B. dry solid for injection
C. injectable emulsion D. injectable suspension
4. Method of sterilization conducted in an autoclave is:
A. steam sterilization B. dry heat sterilization
C. sterilization by filtration D. gas sterilization
5. The following sterile fluids are classified as large volume parenterals EXCEPT:
A. Ringer's injection B. Total parenteral nutrition
C. Humulin R D. Dextrose 5% injection
6. Parenterals drug products should possess the following characteristics EXCEPT:
I. Sterilized using either autoclaving, dry heat or bacterial filtration
II. Isotonic
III. Colored
A. I, II and III B. II and III
C. I and II D. only III
7. Intrathecal administration is the injection of drug into the:
A. joint fluid area B. spinal fluid
C. heart D. under the skin
8. Irrigation solutions are:
I. Sterile solutions
II. Intended to bathe or wash wounds, surgical incisions or body tissues
III. Injected into veins
A. I, II and III B. II and III
C. I and III D. I and II
9. Ringer's Injection USP contains:
I. Sodium chloride
II. Potassium chloride
III. Calcium chloride
A. I, II and III B. II and III
C. I and II D. only III
10. IV administration is needed when:
I. An immediate action is required
II. An oral administration is ineffective
III. A prolonged action is required
A. I, II and III B. I and II
C. II and III D. I and III
11. Method of sterilization employed for heat-labile enzyme preparations, catheters, needles
and plastic disposable syringes.
A. Sterilization by ionizing radiation B. Gas sterilization
C. Dry heat sterilization D. Steam sterilization
12. Commonly used fixed oils in injections include all of the following EXCEPT:
A. corn oil B. peanut oil
C. sesame oil D. mineral oil
13. This is a long acting insulin.
A. Insulin zinc ultralente B. Isophane (NPH) insulin
C. Insulin lispro D. Regular insulin
14. Parenteral preparations are of different types. Which of the following is a dry Solid for
injection?
A. Propofol, USP ​B. Cefuroxime for injection, USP
C. Methylprednisolone Acetate Susp., USP D. Insulin injection, USP
15. Sterile, pyrogen limited preparations intended to be administered parenterally.
A. aerosols B. injections
C. Ophthalmic solution D. None of the above