Republic of the Philippines

University of Science and Technology of Southern Philippines

COLLEGE OF AGR ICULTURE
Claveria, Misamis Oriental
Telefax (088) 3581465; Tel.(088) 358-1465 local 241 www.moscat.edu.ph

CS 520/620: Crop Environmental Physiology and Ecology

This will be submitted on or before June 3, 2019 at 12:00noon. Please email your output to:
[email protected] and [email protected]

GUIDELINES IN PREPARING A CRITIQUE PAPER REPORT

Journal must be within 10 years from the current year, either print or electronic. Be
sure that the Journal contains: title including author(s), abstract/summary, keyword(s),
introduction, review of related literature (depending on journal specification), materials
and methods, results and discussion (depending on journal specification), and lastly
summary, conclusion and recommendation.

1. Write the full information of the source(s):

Family Name, Initials of First Name and Middle Name, (the succeeding
authors will be initials of first name and middle name then Family Name).
Year. Title (should be in Title Case). Name of journal. Volume (Number of
Issues): page(s).

 Benjamin, S. A., Lee, A. C., & Saunders, W.J. (1999). Classification and
behavior of canine mammary epithelial neoplasms based on life-span
observations in beagles. Veterinary Phatology, 36, 423-436.
Bertagnolli, A. C., Cassali, G. D., Genelhu, M.C.U.S., Costa, F.U.M.A.,
Oliveira,
J.F.C., & Goncalves, P.B.D (2009). Immunohistochemical expressions of
p63 and _np63 in mixed tumors of canine mammary glands and its
relation with p53 expression. Vet. Pathol. 46, 407-415.
Bertagnolli, A.C., Ferreira, E., Dias, E.J., & Cassali, G.D., (2011). Canine
mammary mixed tumours: Immunohistochemical expressions of EGFR
and HER-2. Australian Veterinary Journal, 89, 312-317.
Bostock, D.E. (1986). Canine and feline mammary neoplasms. British
Veterinary Journal, 142, 506-515.
Campo, C. B., Lavalle, G. E.. Ligorio, S.f., Monteiro, L.N., Amorim, R.L., &
Cassali, G.D. (2017). Thalidomide treatment in a canine mammary gland
carsinosarcoma presenting pulomonary metastasis. Advances in Animal
and Veterinary Sciences, 5, 120-126.
Cassali, G.D., Bertagnolli, A.C., Lavalle, G.E., Tavares, W.L.F., Ferreira, e.,
 Silva , A. E., & Campos, C. B. (2009). Perspectives for diagnosis,
prognosis
and treatment of mammary neoplasias in dogs. In 34 th World Small Animal
Veterinary Congress- WSAVA, 14, 173.
Cassali, G.D., Bertagnolli, C.A., Ferreira, E., Gamba, C. O., Araujo, K., &
Campos,
B. (2012). Canine mammary mixed tomours: A review. Veterinary
Medicine International, 1-7.
Cassali, G, D., Lavalle. G.E., Nardi, A.B., Ferreira, E., Bertagnolli, A.C., Estrela-
Lima, A., De Nardi, A.B., et al. (2014). Consensus for the diagnosis,
prognosis and treatment of canine mammary tumors. Brazilian J. Vet.
Pathol. 4, 153-180.
Cassali, G., Damasceno, K., Bertagnolli, A., Estrela-Lima, A., Lavalle, G., Di
Santis, G., et al., (2017). Consensus regarding the prognosis and
treatment of canine mammary tumors. Benign mixed tumors, carcinomas
in mixed tumors and carcinosarcomas. Brazilian Journal of Veterinary
Phatology, 10, 87-99.
Damasceno. K.A., Ferreira, E., Estrela-Lima, A., Gamba, C. O., Miranda, F.F.,
Alves, M. R., et al. (2016). HER-2 and EGFR mRNA expression and its
relationship with versican in malignant matrix-producing tumors of the
canine mammary gland. Plos one, 11(8)
Dutra, A.P., Azevedo, J.G.M., Schmitt, F.C., & Cassali, G.D. (2008). Assessment
of cell proliferation and prognostic factor in canine mammary gland
tumors. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 60, 1403-
1412.
Elston, C. W., & Ellis, I.O. (1998). Assesment of histological gradeSystemic
Pathology. The breast (3rd ed.,). London: Churchill Livingstone365-384.
Estrela-lima, A., Araujo, M. S. S., Costaneto, J.M., Teixeira-Carvalho, A.,
Barrouin-
Melo, S.M., Cardoso, S. V., et al. (2010).Immunophenotypic features of
prognostic factors and survival rates. BMC Cancer [Electronic Resource],
10, 1-14.
Ferreira, E., Bertagnolli, A. C., Cavalcanti, M.F., Schmitt, F.C., & Cassali, G.D.
(2009). The relationship between tumour size and expression of
prognostic markers in benign and malignant canine mammary tumours.
Veterinary and Comparative Oncology, (7), 230-235.
Gilbertson, S.R., Kurzman, I.D., Zachrau, R.E., Hurvitz, A.I., & Black, M.M.
(1983)
Canine mammary epithelial neoplasms:biologic implications of
morphologic characteristics assessed in 232 dogs. Veterinary Pathology,
20, 127-142
Goldschmidt, M.., Pena,L. & Zappulli, V. (2011). Classification and grading of
canine mammary tumors. Veterinary phatology, 48,117-131.
Goldschmidt, M. H. Pena, L., & Zappulli, V. (2017). Tumors of the mammary
gland.
In D. j. Meuten (Ed.) Tumors in domestic animals (pp. 731-773). (5 th ed.).
Karayannopoulou, M., Kaldrymidou, E., Constantinidis, T. C., & Dessiris, A.
(2001).
 Adjuvant post-operative chemotheraphy in bitches with mammary cancer.
J. Vet. Med. A. Physioll. Pathol. Clin. Med. 48, 85-96.
Karayannopoulou, M., Kaldrymidou, E., Constantinidis, T. C., Dessiris (2005).
Histological grading and prognosis in dogs with mammary carcinomas:
Application of a human grading method. Journal of Comparative
Pathology, 133, 246-252.
Lavalle, G. E., Bertagnolli, A. C., Travares, W.L.F., & Cassali, G.D. (2009). Cox-2
expression in canine mammary carcinomas: Correlation with angiogenesis
and overall survival. Veterenary Phatology, 46, 1275-1280.
Lavalle, G. E., Campos, C. B., Bertagnolli, A.C., & Cassali, G.D. (2012). Canine
malignant mammary gland neoplasms with advanced clinical staging
threated with carboplatin and ecylcooxygenase inhibitors. In Vivo (Athens,
Greece), 26, 375-379.
Misdorp, w.,& Cotchin E., Hampe, J. f., Jabara, A.G., & Sandersleben, J.V.
(1973). Canine malignant mammary tumors specialtypes of carcinomas,
malignant mixed tumors. Veterinary Pathology, 10, 241-256.
Misdorp, w., & Hart, A. A. (1976). Prognostic factors in canine mammary cancer.
Journal of the National Cancer Institute, 56, 779-786.
Misdorp, W., (1999). Histological classification of the mammary tumors of the dog
and the cat. In S. Series (Ed) . WHO international histological classification
tumors of domestic animals. Washington , DC: AFIP.
Moulton, J., Rosenblatt , L., & Goldman, M. (1986). Mammary tumors in a colony
of beagle dogs. Veterinary Phatology, 23, 741-749.
Moulton, J. E., Taylor, D. O., & Dorn, C, R. (1970). Andersen AC. Canine
Mammary
Tumors. Phatologia Veterinaria, 7, 289-320.
Owen, L. (1980). TNM classification of tumours in domestic animals. World
Health
Organisation1-52.
Pierini, A., Bocci, G., Giorgi, M., Owen, H., & Marchetti, V. (2012). From humans
to dogs and back: The translation lesson of metronomic chemotherapy.
American Journal of Animal and Veterinary Sciences, 7, 198-1212.
Raje, N., & Anderson, K.C. (2002). Thalidomide and immunodulatory drugs as
Cancer therapy. Current Opinion in Oncology, 14, 635-640.
Santos, M., Correla-Gomes, C., Marcos R., Santos, A., De Matos, A., Lopes, C.,
et al. (2015). Value of the Nottingham histological grading parameters and
nottingham prognostic index in canine mammary carcinoma. Anticancer
Research 35, 4219-4228.
Sarli, G., Preziosi, R., Benazzi, C. G. C. & Marcatto, P. S. (2002). Prognostic
value
of Journal of veterinary Diagnostic Investigation Investigation, 14, 24-32.
Sorenmo, K. u., (2003), Ganine mammary gland tumors. Veterinary Clinics of
North America. Small Animal Practice, 33, 573-596.
Sorenmo, K. U., Kristiansen, V.M., & Cofone, M. A. (2009). Canine mammary
Gland tumours: a histological continuum from benign to malignant; clinical
and histopathological evidence. Vet. Comp. Oncol. 7, 162-172.
Sorenmo, K.U., Worley, D., & Goldschmidt, M.H. (2013). Tumors of the
mammary
 Gland. In S.J. Withdraw, D.M. Vail, & R.L. Page (Eds). Withdraw and
MacEwen’s small animal clinical oncology (pp. 538-556). (5th ed.). St.
Louis: Saunders Elsevier.
Toribio, J.M.D.M.L., Lima, A. E., Martins, F.E.F., Ribeiro, L.G.R., Assist,
M.J.M.H.,
Teixeira, R. G., et al (2012). Clinical characterization, histopathologic
diagnosis and geoprocessing of mammary tumours in bitches from the city
of Salvador, Bahia Satate. Revista Ceres, 59, 427-433.
Von Euler, H. (2011). Tumors of the mammary gland. In J.M. Dobson, & B.
Lascelles (Eds.). BSAVA Manual of canine and feline oncology (pp. 237-
247). (3rd ed.). Gloucester: British small Animal Veterinary Association.
Yamagami, T., kobayashi, T., Takahashi, K., & Sugiyama, M. (1996). Prognosis ,
For canine malignant mammary tumors based on TNM and histologic
classification. Journal of Veterinary Medical Science, 58, 1079-1083
(For Items 2 to 6  at least 10 sentences each)

2. Highlights (brief summary of major concepts, paraphrase or quote of the major

points) and Comments/Critics 
a. INTRODUCTION
Highlights:
 Mixed tumors are the most frequent mammary gland neoplasms in bitches
(Cassali et al., 2012). Microscopically, benign mixed tumors are
characterized by benign epithelial, myoepithelial, and mesenchymal
elements, along with the presence of cartilage and/or bone (Misdorp et al.,
1999).
 Studying the epidemiological and clinicopathological characteristics of mix
tumors provides important information that helps in understanding behavior.
Comments/Critique
 This study evaluated the epidemiological and clinicopathological data,
prognostic factors, and treatment approach in bitches with mixed tumors and
is the first study to present these evaluations using a large number of cases.
b. REVIEW OF RELATED LITERATURE (optional depending on journal
specification)
Highlights:
 Carcinosarcomas are mammary neoplasms with both malignant epithelial and
mesenchymal components (Misdorp et al., 1999).
 Mammary tumor prognosis is influenced be several factors including age,
histological type and grade, clinical staging, tumor size, tumor biological
behavior, mitotic index, regional or distant metastases, microvessel density,
and molecular markers (Sorenmo, 2003; Cassali et al.,2014)
Comments/Critique
 This study about mammary tumor prognosis is connected to the several
factors where it can affect or influence the mammary tumor prognosis.
c. MATERIALS AND METHODS
Highlights:
 In total, 904 bitches were included and diagnosed with mixed tumors that
were histologically classified as follows: 162 benign mixed tumors, 682
carcinomas in mixed tumors, and 60 carsinosarcomas.
 Comments/Critique
 Survival was defined as the time in a days between the tumor’s surgical
excision and the animal’s death from disease progression. Animals that died
of unknown causes or causes unrelated to the tumor and those that were lost
to follow-up were not included in the analysis.
d. RESULTS AND DISCUSSION
Highlights:
 Carcinomas in mixed tumors were the most frequent, representing 75%
(682/904) of cases, followed by benign mixed tumors at 18% (162/904).
 Most bitches with mixed mammary neoplasms were purebred, intact,
presented regular estrous cycles, and had never received hormones.
Pseudocyesis was observed in more than half the benign mixed tumors
cases but was absent in most bitches with carcinomas in mixed tumors and
carcinosarcomas.

Comments/Critique
 The mixed tumors presented high heterogeneity regarding morphological
characteristics, clinical progression, and response to combination therapy.
e. SUMMARY, CONCLUSION AND RECOMMENDATION
Highlights:
 Carcinomas in mixed tumors are neoplasms that present good biological
behavior, but depending on their epithelial histological subtypes, their
prognosis may vary. However, even at advanced stages, bitches with
carcinomas in mixed tumors’ survive longer than bitches with
carcinosarcomas.
Comments/Critique
 These mixed tumors’ different biological behaviors, evaluating each patient
and considering all prognostic factors are important for adopting adequate
and individualized therapeutic protocols.

3. Present an idea or concept in the article or research which interest to you, which
you would like to know more to read further. State in your own words as much as
possible but shows where in the article or research the ideas or concepts occur.
 The idea in the article or research which I interested the most is the table 2
which showcased the Epidemiological, clinical, and pathological
characteristics according to the histological classification of mixed tumors in
bitches. I would like to know more or to read further about the table 1 which is
the study of Clinical staging of bitches with mammary tumors according to the
modified version of the original TNM system established by the WHO (5).

4. Give an idea or concept with which you disagree, or with the interpretation or
emphasis of which you disagree. Show where in the article or research study it
occurs and show the basis of your disagreement – with what other evidence,
knowledge, or concept of yours does this idea conflict, and why does this other
knowledge seem more valid than the author’s presentation? Be sure to make
your discussion specific.
  I don’t have any idea or concept with which I disagree because the study was
accurate base to the table presented showcased the Clinical staging of
bitches with mammary tumors according to the modified version of the original
TNM system established by the WHO (5) and Epidemiological, clinical, and
pathological characteristics according to the histological classification of
mixed tumors in bitches. And there is no concept in me that does idea conflict.
5. Would you recommend this article or research results to someone? Why or Why
not?
 I would recommend this article or research results to someone because this
study evaluated the epidemiological and clinic pathological data, prognostic
factors and therapeutic approaches for bitches with mixed tumors were we
can gain knowledge and learn something that is important in our daily living.
6. What class or group of readers do you think would find this article or research
useful, helpful or interesting? Why?
 The class or group of readers I think would find this article or research useful,
helpful or interesting are those people who make study that is related with this
topic.
7. Attachment: photocopy or prints of the journals