Campilobacter: Yutika Kun

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Campilobacter

yutika kun
|MAY.17
I. Characteristic
 Curved, spiral, S-shaped
 Microscopically resemble vibrios
 A single, polar flagellum provides the organism with its characteristic darting motility.
 Microaerophilic: they required oxygen but at lower concentrations than that found in air.
 They use a respiratory pathway and do not ferment carbohydrates
 Campylobacter infect the intestine and can cause ulcer-active, inflammatory lesions in the
jejunum, ileum, or colon. Bacteremia may occur.

II. Epidemiology
 They are widely distributed in nature as commensals of many different vertebrate species, and
served as reservoirs of infection.
 Transmitted via fecal-oral route.

III. Pathogenesis and clinical significance


 They may cause both intestinal and extraintestinal disease
 Bacterial food-borne illness
 Food infection: have longer incubation periods and required colonization by bacterium.
 Food poisoning: have shorter incubation periods and only required ingestion of the
toxin.
 Campylobacter jejuni is a cause of both traveler’s diarrhea and pseudoappendicitis
(symptoms simulating appendicitis without inflammation of the appendix).
 Virulence factors includes a cytotoxin that may be involved in inflammatory colitis and
an enterotoxin that results in increased adenylyl cyclase activity and, therefore,
electrolyte and fluid imbalance.

IV. Laboratory identification


 Can be isolated from feces using special selective media and microaerophilic conditions

V. Treatment and prevention


 Diarrhea should be treated symptomatically with fluid and electrolyte replacement.
 For c. jejuni ciprofloxacin is the drug of choice
 For C. fetus ampicillin or third-generation cephalosporins are effective
Gram (-) rods o Curved, spiral, or S –shaped rods
o Single, polar flagellum, resulting
in characteristic darting motion
o Microaerophilic
Campylobacter o Do not ferment carbohydrates
o Culture on selective medium

species (blood agar containing antibiotics


to inhibit growth of other fecal
flora)

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