Quality Assurance Unit Assiut University Department of Faculty of Pharmacy

Quality Assurance Unit Course Specification Assiut University
Department of ………………… Faculty of Pharmacy

Biopharmaceutics and Pharmacokinetics
Program(s) on which the course is given: B. Pharm. (Clinical Pharmacy)

Major or Minor element of program: Major element
Department offering the program: Faculty of Pharmacy
Department offering the course:Pharmaceutics
Academic year / Level: 2012 / 2013(second semester)– 3rdyear of the program
Date of specification approval:
A- Basic Information
Title: Biopharmaceutics and Pharmacokinetics Code: PT 609
Credit Hours: 3 Lecture: 2hours/week
Tutorial/Practical: 1 hour/weekTotal: 42 hours/semester
B- Professional Information
1. Overall Aims of Course
The course aims at enabling the students to acquire and understand the basic
knowledge of pharmacokinetics and biopharmaceutics. This will enable the students
to design, monitor and modify dosage regimen.
2. Intended Learning Outcomes of Course(ILOs)

a-Knowledge and Understanding :
al- Describe the basic principles of pharmacokinetics and biopharmaceutics.
a2- Define various aspects concerning drug absorption, distribution and elimination
in the body.
a3- Illustrate the theoretical basis of each pharmacokinetic process.
b-Intellectual Skills
b1-Analyze patients data and identify problems in drug disposition.
b2-Plan a strategy for good pharmaceutical care based on the pharmacokinetics data.
b3-Calculate drug pharmacokinetic parameters including half-life, elimination rate
constant, etc.
c- Professional and practical Skills

c1-Identify and monitor patient data during each pharmacokinetic process.
c2-Recommended initial dosage regimen, adjust dosage and recommend monitoring
strategy.
d- General and Transferable Skills

d1- Correlate in vitroand in vivo data.
d2- Apply all the pharmacokinetic data in the form of equations and figures.
١

3- Contents
No. of Tutorial /
Topic Lecture
hours Practical
Introduction and definitions
10 6 4
Absorption of drugs from GIT
Factors affecting drug absorption 3 2 1
Pharmacokinetic models 10 6 4
Drug Distribution and protein binding 9 8 1
Drug elimination and clearance concept
A- Renal drug excretion
10 6 4
B- Biliary excretion
C- Clearance
Total 42 28 14
Practical Lessons
Topics Week
Introduction 1
Intravenous bolus injection 2-3
Urinary excretion data 4-5
Oral absorption 6-7
Bioavailability, drug clearance 8-10
Intravenous infusion 11-12
Multiple dose 13-14
4- Teaching and Learning Methods

4.1- Lectures
4.2- Interactive discussions
4.3- Practical lessons and demonstrations
5- Student Assessment Methods

5.1- Class discussions: to assess understanding and knowledge.
5.2- Semester work: (quizzes, reports, group project) to assess
professional and intellectual skills.
5.3- Practical exam: to assess professional and intellectual skills.
5.4- Written final exam: to assess understanding and knowledge.
5.5- Oral exam: to assess understanding, intellectual and communication skills.
Assessment Schedule
No. Assessment week
1. Problem solving lessons Every week
2. Reports and presentations 13th weeks
3. Practical exam 14th week
4. Oral exam 16th week
5. Final written exam 16th week
٢

Weighting of Assessments
No. Exam. Mark %
1 Final-Term Examination 50 50
2 Oral Examination 15 15
3 Practical Examination (including 25 25
problem solving skills and reports and
presentation)
4 Semester Work/ Mid-Term 10 10
Examination
Total 100 100%
6- List of Reference
6.1- Essential Books (Text Books)
-Biopharmaceutics and Clinical Pharmacokinetics, Robert E. Notari (editor),
Taylor & Francis, 1986.
-Applied Biopharmaceutics and Pharmacokinetics,Leon Shargel (editor),
McGraw-Hill Medical, 2004.
6.2-Recommended Books:
-Biopharmaceutics and Clinical Pharmacokinetics, Robert E. Notari (editor),
Taylor & Francis, 1986.
-Applied Biopharmaceutics and Pharmacokinetics, Leon Shargel (editor),
McGraw-Hill Medical, 2004.
7- Facilities Required for Teaching and Learning

- Books, database, computers and data show.
Course Coordinator: Prof. Sayed Ismail

Head of Department: Prof. Ibraheem El-Sayed El-Gibaly
Date: 1 / 11/ 2012
٣

Course Title Biopharmaceutics and
Assiut University
Pharmacokinetics
Course Cod. PT609
Faculty of Pharmacy
Pharmaceutics Department Year 2012-2013 Second Term
Matrix of the Intended Learning Outcomes (ILOs) of the Course
Knowledge and Professional and General and Transferable

Topic Week Intellectual Skills
Understanding Practical Skills Skills
Introduction and definitions 1-3 a1, a8 b1,b5 c5, c7, c8 d8

Absorption of drugs from GIT
4 a1, a8 b1, b5, b8 c5, c7 d8
Factors affecting drug absorption
5-7 a1, a8 b1, b5, b8 c5, c7 d8
Pharmacokinetic models
8-11 a1, a8 b1, b5, b8 c5, c7, c8 d8
Drug Distribution and protein binding
Drug elimination and clearance concept 12-14 a1, a8 b1, b5, b8 c5, c7, c8 d8
A- Renal drug excretion
B- Biliary excretion
C- Clearance
Course Coordinator:Prof. Dr. SayedIsmail

Head of Department: Prof. Dr. Ibraheem El-Sayed El-Gibaly
Dean of Faculty: Prof. Gamal Ahmed Saleh
Date: 04/11/2012
٤

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Biopharmaceutics and Pharmacokinetics

Program(s) on which the course is given: B. Pharm. (Clinical Pharmacy)

2. Intended Learning Outcomes of Course(ILOs)

c- Professional and practical Skills

d- General and Transferable Skills

4- Teaching and Learning Methods

5- Student Assessment Methods

7- Facilities Required for Teaching and Learning

Course Coordinator: Prof. Sayed Ismail

Matrix of the Intended Learning Outcomes (ILOs) of the Course

Knowledge and Professional and General and Transferable

Introduction and definitions 1-3 a1, a8 b1,b5 c5, c7, c8 d8

Course Coordinator:Prof. Dr. SayedIsmail

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