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    Proposal Title: Possible Antiviral Drug For Covid-19 Patients Proponent: Belmonte, Camila Shaine C

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    Camila Shaine Belmonte
    This proposal suggests testing the drugs hydroxychloroquine (HCQ) and chloroquine (CQ) as possible antiviral treatments for COVID-19 patients. HCQ and CQ have been used to treat malaria and autoimmune diseases. Literature shows they have antiviral effects by inhibiting virus cell entry and suppressing cytokine storms. The proposal aims to test if HCQ can reduce extreme COVID-19 symptoms by reducing immune overreaction and suppressing the cytokine storm. Since HCQ is already an approved drug, the proposal recommends testing it on COVID-19 patients and conducting more in vitro laboratory tests to determine its effectiveness as an antiviral.

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    Proposal Title: Possible Antiviral Drug For Covid-19 Patients Proponent: Belmonte, Camila Shaine C

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    Camila Shaine Belmonte
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    This proposal suggests testing the drugs hydroxychloroquine (HCQ) and chloroquine (CQ) as possible antiviral treatments for COVID-19 patients. HCQ and CQ have been used to treat malaria and autoimmune diseases. Literature shows they have antiviral effects by inhibiting virus cell entry and suppressing cytokine storms. The proposal aims to test if HCQ can reduce extreme COVID-19 symptoms by reducing immune overreaction and suppressing the cytokine storm. Since HCQ is already an approved drug, the proposal recommends testing it on COVID-19 patients and conducting more in vitro laboratory tests to determine its effectiveness as an antiviral.

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    This proposal suggests testing the drugs hydroxychloroquine (HCQ) and chloroquine (CQ) as possible antiviral treatments for COVID-19 patients. HCQ and CQ have been used to treat malaria and autoimmune diseases. Literature shows they have antiviral effects by inhibiting virus cell entry and suppressing cytokine storms. The proposal aims to test if HCQ can reduce extreme COVID-19 symptoms by reducing immune overreaction and suppressing the cytokine storm. Since HCQ is already an approved drug, the proposal recommends testing it on COVID-19 patients and conducting more in vitro laboratory tests to determine its effectiveness as an antiviral.

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    28 views2 pages

    Proposal Title: Possible Antiviral Drug For Covid-19 Patients Proponent: Belmonte, Camila Shaine C

    Uploaded by

    Camila Shaine Belmonte
    This proposal suggests testing the drugs hydroxychloroquine (HCQ) and chloroquine (CQ) as possible antiviral treatments for COVID-19 patients. HCQ and CQ have been used to treat malaria and autoimmune diseases. Literature shows they have antiviral effects by inhibiting virus cell entry and suppressing cytokine storms. The proposal aims to test if HCQ can reduce extreme COVID-19 symptoms by reducing immune overreaction and suppressing the cytokine storm. Since HCQ is already an approved drug, the proposal recommends testing it on COVID-19 patients and conducting more in vitro laboratory tests to determine its effectiveness as an antiviral.

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    © All Rights Reserved
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    of 2

    Technological Institute of the Philippines

    Department of Chemical Engineering


    Principles of Biochemical Engineering

    Proposal Title: Possible antiviral drug for Covid-19 patients


    Proponent: Belmonte, Camila Shaine C.

    RATIONALE

    Let us be really rational about this pandemic that every country is now facing . The Covid-19
    is not going to vanish in the near future. This virus has been shown to be extremely
    infectious with a fast incubation time in humans that cause hundreds of new cases everyday
    here in the Philippines. That's why the government is keen to discover a way to suppress the
    replication of the virus, and this research aims to develop possible antiviral medications.

    REVIEW OF LITERATURE

    The novel coronavirus disease or COVID-19 caused by SARS-CoV-2 infection has spread
    quickly in many countries worldwide. The transition from early signs to acute respiratory
    distress syndrome is very likely to be due to uncontrolled production of cytokines and it can
    be dangerous due to an overreaction of the human immune system (A. George,2020). An
    antiviral drug called chloroquine (CQ) is being developed for the medication of malaria and
    HIV-1/aids, a drug well known for its effectiveness in the treatment of autoimmune disease,
    and insights into its antiviral activity have also been obtained from in vitro studies (Dr. A.
    Savarino et al,. 2006). Also, there’s a Hydroxychloroquine (HCQ) which has the same
    chemical formula with chloroquine is known to have a strong immunomodulatory potential
    which really stops flare-up inflammation and organ damage (Dan Zhuo et al., 2020).

    HCQ and CQ,in terms of immune regulation is said to inhibit the binding of receptors and
    membrane fusion, two main steps should be taken for coronavirus cell entry. CQ has been
    shown to have an antiviral effect throughout pre-and post-infection conditions by
    suppressing angiotensin-converting enzyme 2 (ACE2) glycosylation (SARS-CoV cellular
    receptor) and blocking virus fusion fast (Dan Zhuo et al., 2020).

    OBJECTIVES

    The objective of the study is emphasize the possible effectiveness of hydrochloroquine


    (HCQ) and chloroquine(CQ) for the treatment of fast growing number of Covid -19 patients.

    METHODOLOGY

    Since, hydrochloroquine is already a drug which is known as Plaqueniel, and used as to treat
    malaria and to treat rheumatoid arthritis,it might also used as antiviral drug for Covid-19
    patients. In addition, HCQ can improve intracellular pH and suppress lysosomal activity in
    antigen-presenting cells (APCs), including plasmacytoid dendritic cells (pDCs) and B cells,
    therefore preventing the processing of antigens and major histocompatibility complex
    (MHC) class II-mediated autoantigen presentation to T cells (Dan zhouet al,.2020)
    Figure 1.The chemical structures of CQ and HCQ.

    HCQ is expected to reduce the extreme development of COVID-19 by suppressing the


    cytokine storm by reducing CD154 production in T cells. Since CQ and HCQ share similar
    chemical structures and pathways to serve as a weak base and immunomodulator, it is
    simple to summon up up the possibility that HCQ might be a potent agent for SARS-CoV-2
    infection.

    Since it is available drug in the market, test it to Covid-19 patients and more laboratoy test in
    vitro is necessary. There is an immediate need to distinguish the effectiveness of this drug.

    References:
    Alison George,(2020) Cytokine Storm: An overreaction of the Body’s immune system, doi:
    https://www.newscientist.com/term/cytokine-storm/
    Dr. A. Savarino et al,. (2006) New insights into the antiviral effects of chloroquine, doi:
    https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(06)70361-9/fulltext
    Dan Zhou et al,.(2020)COVID-19: a recommendation to examine the effect of
    hydroxychloroquine in preventing infection and progression,
    https://doi.org/10.1093/jac/dkaa114

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