Summary Guaifenesin is a fluffy, low-melting-point expectorant. It is tablet with excellent formulation and tableting characteristics. poorly flowing and poorly compressible and is typically granu- In a comparison study, PROSOLV ® SMCC HD 90 provided lated prior to solid dosage form manufacture. The typical harder, smaller tablets at lower compaction forces than dosage of Guaifenesin is a 200 mg/tablet. PROSOLV ® SMCC comparable high-density Microcrystalline Cellulose HD 90 faciliated a directly compressible, quickly disintegrating formulations.
Formulation Active content [mg] mg/tablet Contribution [%] Guaifenesin 200.0 200.0 40.0 PROSOLV ® SMCC HD 90 (Silicified Microcrystalline Cellulose) 295.0 59.0 Talcum 5.0 1.0 Total 500.0 100.0
Procedure Blending: PROSOLV ® SMCC HD 90 and Talcum were dispensed to the correct masses and transferred to a Patterson-Kelly twin-shell V-blender. Guafenesin was sieved and transferred into the V-blender. The powders were blended for 5 minutes. The powder mixture was ready for direct compression.
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