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    Phloroglucinol Trimethyloroglucinol

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    Tablets and There uses

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    Phloroglucinol Trimethyloroglucinol

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    ziaddd
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    Tablets and There uses

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    phloroglucinol_trimethyloroglucinol

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    Tablets and There uses

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    Download as pdf or txt
    228 views1 page

    Phloroglucinol Trimethyloroglucinol

    Uploaded by

    ziaddd
    Tablets and There uses

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    FORMULATION HANDBOOK

    # 4282-048 Key Words: Trimethylphloroglucinol,


    Phloroglucinol, Poor Flowability,
    Phloroglucinol / Multi Dosage, Direct Compression
    JRS Products: PROSOLV ® SMCC 90, EMDEX ®,
    Trimethylphloroglucinol VIVASOL® , PRUV ®
    Direct Compression Page 1

    Summary
    Phloroglucinol and Trimethylphloroglucinol are naturally disorders. Both APIs exhibit poor flow and are not readily
    occurring polyphenols often used in combination as an compressible. The following direct compression formulation
    antispasmodic to relieve symptoms of gastrointestinal overcomes these difficulties.

    Formulation
    Active Content [mg]/tablet Contribution [%]
    Phloroglucinol 80.0 80.0 16.0
    Trimethylphloroglucinol 80.0 80.0 16.0
    PROSOLV ® SMCC 90 (Silicified Microcrystalline Cellulose) 215.0 43.0
    EMDEX® (Dextrates) 108.0 21.6
    VIVASOL® (Croscarmellose Sodium) 10.0 2.0
    PRUV ® (Sodium Stearyl Fumarate) 7.0 1.4
    Total 500.0 100.0

    Procedure
    Blending:
    All substances, except PRUV ® , were blended for 30 minutes in a turbula powder blender. The lubricant was added and the
    powder was mixed in a V-blender for another 3 minutes. The powder mixture was ready for direct compression.

    Equipment:
    Tablet Press Korsch EK 0
    Turbula Mixer Type T2A
    Hardness Tester Schleuniger 6D

    Tablet Characteristics
    Tablet Weight: 500 mg
    Tablet Diameter: 13 mm
    Compaction Force: 20 kN
    Crushing Strength: 100 N

    Disclaimer: The information provided is based on thorough research and is believed to be completely reliable. Application suggestions are
    given to assist our customers, but are for guidance only. Circumstances in which our material is used vary and are beyond our control.
    Therefore, we cannot assume any responsibility for risks or liabilities, which may result from the use of this technical advice.

    WORLDWIDE HEADQUARTERS
    JRS PHARMA GMBH & CO. KG
    73494 Rosenberg (Germany)
    Phone: + 49 (0) 7967 / 152 312 [email protected]
    Fax: + 49 (0) 7967 / 152 345 www.jrs.de

    Customer Service: +49 (0) 7967 / 152 312 www.jrspharma.com

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