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    ASSIGNMENT

    Uploaded by

    Mae Maricar
    Celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and specific COX-2 enzyme inhibitor used to treat pain and inflammation from conditions like rheumatoid arthritis and osteoarthritis by inhibiting the COX-2 enzyme involved in inflammation while sparing the COX-1 enzyme that protects the stomach; it has potential contraindications with allergies, renal or liver impairment, and risks of side effects like headaches, dizziness, and gastrointestinal bleeding; and nursing responsibilities involve assessment of risks, instructing patients on administration and monitoring for side effects.

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    ASSIGNMENT

    Uploaded by

    Mae Maricar
    18 views2 pages
    Celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and specific COX-2 enzyme inhibitor used to treat pain and inflammation from conditions like rheumatoid arthritis and osteoarthritis by inhibiting the COX-2 enzyme involved in inflammation while sparing the COX-1 enzyme that protects the stomach; it has potential contraindications with allergies, renal or liver impairment, and risks of side effects like headaches, dizziness, and gastrointestinal bleeding; and nursing responsibilities involve assessment of risks, instructing patients on administration and monitoring for side effects.

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    Celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and specific COX-2 enzyme inhibitor used to treat pain and inflammation from conditions like rheumatoid arthritis and osteoarthritis by inhibiting the COX-2 enzyme involved in inflammation while sparing the COX-1 enzyme that protects the stomach; it has potential contraindications with allergies, renal or liver impairment, and risks of side effects like headaches, dizziness, and gastrointestinal bleeding; and nursing responsibilities involve assessment of risks, instructing patients on administration and monitoring for side effects.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    18 views2 pages

    ASSIGNMENT

    Uploaded by

    Mae Maricar
    Celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and specific COX-2 enzyme inhibitor used to treat pain and inflammation from conditions like rheumatoid arthritis and osteoarthritis by inhibiting the COX-2 enzyme involved in inflammation while sparing the COX-1 enzyme that protects the stomach; it has potential contraindications with allergies, renal or liver impairment, and risks of side effects like headaches, dizziness, and gastrointestinal bleeding; and nursing responsibilities involve assessment of risks, instructing patients on administration and monitoring for side effects.

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    © All Rights Reserved
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    Generic Name: Celecoxib

    Brand Name: Celebrex


    Drug Classification: Analgesic (nonopioid); NSAID; Specific COX-2 enzyme inhibitor; Antirheumatics
    Mechanism of Action: Analgesic and anti-inflammatory activities relate to inhibition of the COX-2 enzyme,
    which is activated in inflammation to cause the signs and symptoms associated with inflammation; does not
    affect the COX-1 enzyme, which protects the lining of the GI tract and has blood clotting and renal functions
    Indications:

    - Acute and long-term treatment of signs and symptoms of rheumatoid arthritis and osteoarthritis
    - Reduction of the number of colorectal polyps in familial adenomatous polyposis (FAP)
    - Management of acute pain
    - Treatment of primary dysmenorrhea
    - Relief of signs and symptoms of anklylosing spondylitis
    - Relief of signs and symptoms of juvenile rheumatoid arthritis

    Contraindications and cautions:

    - Contraindicated with allergies to sulfonamides, celecoxib, NSAIDs, or aspirin; significant renal


    impairment; perioperative pain post CABG surgery; pregnancy (third trimester); lactation
    - Use cautiously with impaired hearing, hepatic and CV conditions

    Side effects:

    - Dizziness, drowsiness

    Adverse effects:

    - CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, tinnitus, ophthalmologic effects
    - CV: MI, CVA
    - Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
    - GI: Nausea, abdominal pain, dyspepsia, flatulence, GI bleed
    - Hematologic: Neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytes,
    granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia
    - Other: Peripheral edema, anaphylactoid reactions to anaphylactic shock

    Nursing Responsibilities:

    Before:

    Assessment

    - History:  Renal impairment, impaired hearing, allergies, hepatic and CV conditions, lactation, pregnancy

    - Physical: Skin color and lesions; orientation, reflexes, ophthalmologic and audiometric evaluation,
    peripheral sensation; P, edema; R, adventitious sounds; liver evaluation; CBC, LFTs, renal function
    tests; serum electrolytes
    During:

    - Instruct patient to take drug with food or milk- Teach patient to avoid aspirin and other NSAIDs (such as
    ibuprofen and naproxen) during therapy.
    - Instruct patient to take celecoxib exactly as directed. Do not take more than prescribed dose.
    - Instruct patient in correct technique for monitoring BP and to notify health care professional if
    significant changes occur.

    After:

    - Advise patient to notify health care professional promptly if signs or symptoms of GI toxicity
    (abdominal pain, black stools), cardiovascular effects (chest pain, shortness of breath, weakness, slurring
    of speech), skin rash, unexplained weight gain, or edema occurs. Patients should discontinue celecoxib
    and notify health care professional if signs and symptoms of hepatotoxicity (nausea, fatigue, lethargy,
    pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.

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