Furosemide

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Alunsabe, Cesar Jr. B NPF-1/ BSN-4 A.

Commonly drugs prescribed for Kidney disease Drug Mechanism of Dosage Route Action & Indication & frequency
A. Generic name : furosemide B. Brand name : - Lasix , Uritol, - Myrosemide C. Functional class : - Loop diuretic Action: Acts on the ascending loop of Henle in the kidney, inhibiting reabsorption of electrolytes sodium and chloride, causing excretion of sodium, calcium, magnesium, water and some potassium; decreases reabsorption of sodium and chloride and increase excretion of potassium in the distal tubule of the kidney; responsible for slight antihypertensive effect and peripheral vasodilation. Indication: Edema in CHF, nephritic syndrome, ascites, caused by hepatic disease, hepatic cirrhosis; may be used alone or as adjunct with antihypertensive such as spironelactone, triamterene; should not be used with ethacrynic acid. Adult: PO 20-80 mg/day in am may give another dose in 6 hr, up to 600 mg/day IM/IV 20-40 mg, increased by 20 mg q2h until desired response y y

CI: Nathaniel G. Denna, RN, MAN January 2, 2012 Adverse Effects


ringing in your ears, hearing loss; feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; painful or difficult urination; pale skin, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; feeling light-headed or short of breath, rapid heart rate, trouble concentrating; nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); sudden numbness or weakness, especially on one side of the body; skin rash, bruising, severe tingling, pain, muscle weakness; dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, uneven heart rate, fainting, or seizure (convulsions); numbness or tingly feeling around your mouth, muscle tightness or contraction, overactive reflexes; headache, trouble concentrating, weakness, loss of appetite, feeling unsteady, shallow breathing or breathing that stops; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. 

Nursing Intervention
Observe patients receiving parenteral drug carefully; closely monitor BP and vital signs. Sudden death from cardiac arrest has been reported.  Monitor BP during periods of diuresis and through period of dosage adjustment.  Observe older adults closely during period of brisk diuresis. Sudden alteration in fluid and electrolyte balance may precipitate significant adverse reactions. Report symptoms to physician.  Lab tests: Obtain frequent blood count, serum and urine electrolytes, CO2, BUN, blood sugar, and uric acid values during first few months of therapy and periodically thereafter.  Monitor for S&S of hypokalemia (see Appendix F).  Monitor I&O ratio and pattern. Report decrease or unusual increase in output. Excessive diuresis can result in dehydration and hypovolemia, circulatory collapse, and hypotension. Weigh patient daily under standard conditions.  Monitor urine and blood glucose & HbA1C closely in diabetics and patients with decompensated hepatic cirrhosis. Drug may cause hyperglycemia.  Note: Excessive dehydration is most likely to occur in older adults, those with chronic cardiac disease on prolonged salt restriction, or those receiving sympatholytic agents. Patient & Family Education  Consult physician regarding allowable salt and fluid intake.  Ingest potassium-rich foods daily (e.g., bananas, oranges, peaches, dried dates) to reduce or prevent potassium depletion.  Learn S&S of hypokalemia (see Appendix F). Report muscle cramps or weakness to physician.  Make position changes slowly because high doses of antihypertensive drugs taken concurrently may produce episodes of dizziness or imbalance.  Avoid replacing fluid losses with large amounts of water.  Avoid prolonged exposure to direct sun.  Do not breast feed while taking this drug.

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Child: PO /IM/IV 2mg/kg, may increase by 1-2 mg/kg/q6h-8h up to 6mg/kg

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