Chemdraw Kimia Medisinal

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A.

Membuat Gambar Struktur Kimia 2D dan Memberi Nama IUPAC dari Senyawa Obat

O
O NH2
S

O
F
N
OH N
F

OH

salicylic acid
2-hydroxybenzoic acid
celecoxib
4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

O
HO

O
O

O
H

simvastatin
(1R,3S,7R,8R,8aS)-8-(2-((2R,4S)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-
1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

HO O

OH
O H

ibuprofen
N
2-(4-isobutylphenyl)propanoic acid
HO
morphine
(4R,4aR,7S,7aR,12bS)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-
4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
B. Menggambar Struktur Senyawa dari Template

1. Amino Acids

O H2N CH C OH

H 2N CH C OH CH2

CH3 CH2

alanine CH2

NH

C NH

NH2

arginine
2. DNA Template

NH2

N
N

N
N
HO

O
H H

H H
OH H
(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
Adeninedeoxyribosenucleoside

N
NH

N
O N NH2

-
O P O
O
O- H H

H H
OH H
((2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-
yl)methyl phosphate
Guaninedeoxyribosenucleoside
3. RNA Template

NH2

N O
HO

O
H H

H H
OH OH
4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Cytosineribonucleoside

NH

N O
O

-
O P O
O

O - H H

H H
OH OH

((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl
phosphate
Uracilribonucleotide
4. Hexoses

CHO

H OH

HO H

H OH

H OH

CH2OH

(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
D-glucose

H OH

H O
HO
HO H
H OH

H OH
(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
D-glucose bentuk -pyranose

H OH

H O
HO
H OH
H OH

OH H
(2R,3R,4R,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
D-glucose bentuk -pyranose
H
H
HO O
HO
HO H

H OH
H OH

(2S,3R,4R,5R)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-2,3,4-triol
D-glucose a-furanose

H
OH
HO O
HO
HO H

H H
H OH

(2R,3R,4R,5R)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-2,3,4-triol
D-glucose bentuk -furanose

C. Menggambar Struktur dari Nama IUPAC

OH N+
O O-

Cl
N
H

Cl OH
chloramphenicol
2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide

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