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    CMR Sedation

    Uploaded by

    Yong Wai
    This document provides dosing guidelines for midazolam and pethidine in both adults and pediatric patients for procedural sedation and analgesia. It lists midazolam as 1 ampoule containing 5 mg/ml for adults and 0.1 mg/kg for pediatrics. Pethidine is listed as 1 ampoule containing 50 mg/ml for adults and 1 mg/kg for pediatrics. Reversal agents are also provided as flumazenil for midazolam and naloxone for pethidine.

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    CMR Sedation

    Uploaded by

    Yong Wai
    161 views2 pages
    This document provides dosing guidelines for midazolam and pethidine in both adults and pediatric patients for procedural sedation and analgesia. It lists midazolam as 1 ampoule containing 5 mg/ml for adults and 0.1 mg/kg for pediatrics. Pethidine is listed as 1 ampoule containing 50 mg/ml for adults and 1 mg/kg for pediatrics. Reversal agents are also provided as flumazenil for midazolam and naloxone for pethidine.

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    CMR SEDATION

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    This document provides dosing guidelines for midazolam and pethidine in both adults and pediatric patients for procedural sedation and analgesia. It lists midazolam as 1 ampoule containing 5 mg/ml for adults and 0.1 mg/kg for pediatrics. Pethidine is listed as 1 ampoule containing 50 mg/ml for adults and 1 mg/kg for pediatrics. Reversal agents are also provided as flumazenil for midazolam and naloxone for pethidine.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    161 views2 pages

    CMR Sedation

    Uploaded by

    Yong Wai
    This document provides dosing guidelines for midazolam and pethidine in both adults and pediatric patients for procedural sedation and analgesia. It lists midazolam as 1 ampoule containing 5 mg/ml for adults and 0.1 mg/kg for pediatrics. Pethidine is listed as 1 ampoule containing 50 mg/ml for adults and 1 mg/kg for pediatrics. Reversal agents are also provided as flumazenil for midazolam and naloxone for pethidine.

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    Adults Paeds

    IV Midazolam IV Midazolam
    1 ampoule = 5 mg / ml 0.1 mg/kg
    ½ dose = 2.5 mg / ml
    Antidote: Flumazenil IV Pethidine
    IV Pethidine 1 mg/kg
    1 ampoule = 50 mg / ml
    ½ dose = 25 mg / ml 20 kg = 1 cc
    Antidote: Naloxone 30 kg = 1.5cc
    40 kg = 2cc
    1cc + 4cc (water of injection) = 5cc 50 kg = 2.5cc
    Half dose = 2.5 cc max 2.5 cc in 2 minutes

    SpO2 monitoring
    Put on NPO2
    Reversal agent

    Commonly Used Drugs for Procedural Sedation and Analgesia in Adults

    Drug Adult Dose Onset of Duration of Common adverse


    Action Action effects
    Midazolam 0.02 – 0.1 mg/kg IV 1 – 2 min 30 – 60 min 1. Respiratory
    initially ; if further depression
    sedation is required , may 2. Hypotension
    repeat with 25% of initial
    dose after 3 – 5 min , not Reversal agent :
    to exceed 2.5 mg/dose Flumazenil
    Fentanyl 1 – 2 mcg/kg slow IV push 1 – 2 min 30 – 60 min 1. Respiratory
    (over 1 – 2 min) ; may depression
    repeat dose after 30 min 2. Hypotension
    3. Dysphoria
    4. Nausea and
    vomiting
    Pethidine 50 – 150 mg PO / IM / SC < 1 min 2 – 4 hours 1. Respiratory
    q3 – 4 hr PRN ; adjust depression
    dose based on degree of
    response Reversal agent :
    Naloxone
    Propofol 0.5 – 1 mg/kg IV loading < 1 min 3 – 10 min 1. Rapidly causes
    dose; may repeat by 0.5 deepening
    mg/kg increments q3- sedation
    5min 2. Cardiovascular
    depression
    3. Hypotension

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