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    Syllabus

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    Prakash Kumar
    This document outlines a course on system biology. The course aims to teach an understanding of biology from a systems-level perspective by examining the structure and dynamics of cellular and organismal functions as interacting networks, rather than isolated parts. The expected outcomes are an ability to predict how biological systems change over time under varying conditions and to develop multiscale models that can discover new disease biomarkers and target treatments. The course consists of 8 modules covering topics like modeling single genes and biochemical networks, kinetic models, stochastic models, and simulating whole cells. Assessment is based on student learning outcomes related to understanding biological systems and developing predictive models.

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    Syllabus

    Uploaded by

    Prakash Kumar
    96 views2 pages
    This document outlines a course on system biology. The course aims to teach an understanding of biology from a systems-level perspective by examining the structure and dynamics of cellular and organismal functions as interacting networks, rather than isolated parts. The expected outcomes are an ability to predict how biological systems change over time under varying conditions and to develop multiscale models that can discover new disease biomarkers and target treatments. The course consists of 8 modules covering topics like modeling single genes and biochemical networks, kinetic models, stochastic models, and simulating whole cells. Assessment is based on student learning outcomes related to understanding biological systems and developing predictive models.

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    System biology

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    This document outlines a course on system biology. The course aims to teach an understanding of biology from a systems-level perspective by examining the structure and dynamics of cellular and organismal functions as interacting networks, rather than isolated parts. The expected outcomes are an ability to predict how biological systems change over time under varying conditions and to develop multiscale models that can discover new disease biomarkers and target treatments. The course consists of 8 modules covering topics like modeling single genes and biochemical networks, kinetic models, stochastic models, and simulating whole cells. Assessment is based on student learning outcomes related to understanding biological systems and developing predictive models.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    96 views2 pages

    Syllabus

    Uploaded by

    Prakash Kumar
    This document outlines a course on system biology. The course aims to teach an understanding of biology from a systems-level perspective by examining the structure and dynamics of cellular and organismal functions as interacting networks, rather than isolated parts. The expected outcomes are an ability to predict how biological systems change over time under varying conditions and to develop multiscale models that can discover new disease biomarkers and target treatments. The course consists of 8 modules covering topics like modeling single genes and biochemical networks, kinetic models, stochastic models, and simulating whole cells. Assessment is based on student learning outcomes related to understanding biological systems and developing predictive models.

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    of 2

    BIT1031 SYSTEM BIOLOGY L T P J C

    3 0 0 0 3
    Pre-requisite BIT 2001 / BIT 2004 Syllabus version
    V.1.0
    Course Objectives:
     It aims at system-level understanding of biology, and to understand biological systems as a
    system. This means an examination of the structure and dynamics of cellular and organism
    function, rather than the characteristics of isolated parts of a cell or organism.

    Expected Course Outcome:


     Gives a holistic approach to decipher the complexity of biological systems by understanding
    the interaction networks
     Provides an ability to predict how these systems change over time and under varying
    conditions, and to develop solutions to health issues
     Provides an ability to design predictive, multiscale models that enables our scientists to
    discover new biomarkers for disease, stratify patients based on unique genetic profiles,
    and target drugs and other treatments

    Student Learning Outcomes (SLO): 2, 4

    Module:1 System-level Understanding of Biological 6 hours SLO: 2,4


    Systems
    Introduction - system level understanding of biological systems - Biological systems: Example.
    Advanced measurement systems - cell lineage and its application

    Module:2 Modeling the Activity of Single Genes 6 hours SLO: 2


    Modeling the activity of single genes - Chemical reactions- Physical chemistry, The Basics of
    Transcription, a probabilistic model of a prokaryotic gene and its regulation

    Module:3 Modeling biochemical networks 7 hours SLO: 2


    Atomic - level simulation and modeling of bio-macromolecules - molecular dynamics – the force field,
    molecular dynamics methods – Monte Carlo methods

    Module:4 Kinetic Models 7 hours SLO: 2


    Kinetic models of excitable membranes and synaptic interactions - Kinetic models of ion channels –
    Voltage-dependent Ion channels – Ligand gated synaptic ion channels

    Module:5 Stochastic Models 6 hours SLO: 4


    Stochastic simulation of cell signaling pathways – Limitations of deterministic models. A novel
    stochastic simulator, Multistate molecules, signalling complex and allostery

    Module:6 Virtual Biology Laboratory 6 hours SLO: 4


    Modeling large biological systems from functional genomic data: Parameter estimation, cellular
    simulation, towards a virtual biology laboratory, computational cell biology, the stochastic
    approach.

    Module:7 Simulation of the Whole Cell 5 hours SLO: 4


    Computer simulation of the whole cell, computer simulation of the cell, human erythrocyte model
    and its application, software for modeling and simulation, E-cell, and V-cell.

    Module:8 Contemporary issues: 2 hours


    Lecture by Industrial Expert

    Total Lecture hours: 45 hours


    Text Book(s)
    1. Uri Alon, 2016 An Introduction to Systems Biology: Design Principles of Biological Circuits, 1st
    Edition, Chapman & Hall/CRC publishers
    Reference Books
    1. Systems Biology: A Textbook- Axel Kowald, Christoph Wierling, Edda Klipp, and Wolfram
    Liebermeister, 2016

    2. Eberhard O. Voit, 2012, A First Course in Systems Biology, 1st Edition, Garland Science

    Recommended by Board of Studies 03-08-2017


    Approved by Academic Council No.47 Date 05.10.2017

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