Lesson Plan - Cloning

Copy Cat
(A lesson plan on Cloning)
Learning Objectives:
At the end of the learning period, the learner should be able to:
a. define key terms associated with cloning;
b. explain the benefits and risk surrounding cloning; and
c. outweigh the benefits and the risks of cloning.
Learning Resources:
a. Kumar, Dinesh. (2018). Retrieved from https://www.slideshare.net/mobile/dineshbhati5209000/cloning-

34236683.
b. Baron, Adrianne. (2018). Retrieved from https://study.com/academy/lesson/cloning-lesson-plan.html.
c. Kopernik. (2018). Retrieved from http://www.kopernik.org.pl/en/special-projects/archiwum-
projektow/projekt-genesis/krotka-historia-klonowania/
d. Genetics. (2018). Retrieved from https://learn.genetics.utah.edu/content/cloning/whatiscloning/
e. Genome. (2018). Retrieved from https://www.genome.gov/25020028/cloning-fact-sheet/
f. Livestrong. (2018). Retrieved from https://www.livestrong.com/article/254843-what-are-the-risks-of-
cloning/
g. Sciencestruck. (2018). Retrieved from https:www.google.com.ph/amp/s/sciencestruck.com/ethical-
issues-of-cloning.amp
Learning Materials:
For activating prior knowledge and the whole setup: Laptop, TV

For motivational activity: Printed material.
Activating Prior Knowledge
1. The students will watch a video clip (trailer of The Island and Multiplicity) and they will write on their
notes their initial responses, thoughts and feelings about the video they have watched.
2. Then ask the following questions:
a. Based on the video you have watched, what key concepts, initial response, and thoughts have you
written on your notes?
b. What have you observed in the video?
c. Is there something similar or common in the video?
d. Can you enumerate those?
1|BTCH1 – Introduction to Biotechnology

Activity:
1. Preparation:
The teacher will distribute paper.
2. The teacher will give instructions:
a. Answer the 4 pics 1 word as fast as you can.
b. The student who will submit the paper with the correct answer will have an additional 2 points in our
quiz.
Analysis:
1. The teacher will ask the following questions after the activity.
a. Based on our activity, what have you observe in the picture?
b. In real life, do they have similar traits?
c. Can you give me some positive and negative effects of cloning?
Abstraction:
1. Based on our activity, can you define what is cloning

2. Do you in favor for cloning?
3. If yes, do you think harvesting organs, tissue and any body parts from clone is right?
4. If you had the option, would you want to clone yourself?
5. Do you think the benefits outweigh the risks with cloning?
Cloning
- Describes a number of different processes that can be used to produce genetically identical copies of
biological entity.
- Creation of an organism that is an exact genetic copy of another.
- Clones are organisms that are exact genetic copies. Every single bit of DNA is identical
History of Cloning
1938 – The first idea of cloning. Hans Spemman proposes a fantastic experiment – to replace the
nucleus of an egg cell with the nucleus of another cell and to grow an embryo from such an egg.
1952 – An attempt to clone a Rana pipiens.
1970 – A Xenopus laevis frog. Development only reaches tadpole.

1981 – Karl Illmenese and Peter Hope clone a mouse. They take the nucleus not from an adult specimen
but from mouse embryo.
1994 – Neal first tries to clone a sheep. He takes the nucleus from embryonic cell.
1995 – Two sheeps are cloned.
1996 – Dolly the sheep. Creator Ian Wilmut and Keith Campbell.
1998 – First cloned mouse.
2000 – First cloned monkey and pig.
2001 – A buffalo, cow and cat cloned.
2002 – Cloned mice from T – lymphocytes.
2003 – A rabbit, mule, and deer cloned.
2004 – Fruit flies cloned. A group of Korean announces an alleged cloning of human embryo.
2005 – afghan hound cloned
2007 – Wolf cloned
2008 – Dog cloned
2009 – First animal from extinct species cloned. A female camel cloned.
Types of cloning
1. Natural cloning – in nature, twins from very early in development when the embryo splits into two.
2. Artificial embryo cloning – is a relatively low-tech way to make clones. This technique mimics the
natural process that creates identical twin. It is carried out in a petri dish instead of inside the mother.
a. Therapeutic cloning – produces embryonic stem cells for experiments aimed at creating tissues to
replaced injured or diseased tissues.
b. Reproductive cloning – It is used to generate an animal that has the same nuclear DNA as another
currently or previously existing animals. Dolly the sheep was created by reproductive cloning
technology in a process called Somatic Cell Nuclear Transfer (SCNT).

c. Gene cloning – Also known as DNA cloning; produces copies of genes or segments of DNA.
Cloning strategies
1. Fragmentation – breaking a part a strand of DNA
2. Ligation – gluing together pieces of DNA in a desired sequence.
3. Transfection – inserting the newly formed pieces of DNA into cells.
4. Screening/Selection – selecting out the cells that were successfully transfected with the new DNA
Potential uses for cloning humans or human cells
1. A research tool to understand how genes in cells can be switched off and on.
2. Growing new skin for burn victims
3. Culturing bone marrow that could be used to treat cancer patients
4. Manipulating genes to cure sickle cell anemia.
5. Potential application in treating infertility.
Benefits of cloning
1. There will be endless supply of animals to clone, and we will never rut out of food from animals.
2. The animal in which we intend to clone will result perfectly the same as the animal which has been
cloned in every way,
3. Chances of curing certain disease and being able to breed ideal stock for research and consumption.
4. Cloning an extinct species to bring them back, to clone organs to repair damaged organs in people, and
variety of other medical advancements.
Risk of cloning
1. Miscarriage
2. Health problems
3. Abnormal gene expression
Legal and ethical issues of cloning
1. It helps homosexual and sterile couples to have biological offspring.
2. Helps in-depth research, like motor neuron disease.
3. Embryonic stem cells can be cloned to produce tissues or organs to replace or repair the damaged ones
4. Human cloning could allow parents who have lost a child a chance to redress their loss using the DNA
of their deceased child
5. Cloning violates the marriage act by separating procreation of children from the unifying act of love
between husband and wife.
Application:
The teacher will post a jumbled picture of steps in cloning and the students will arrange those steps in
order of process.

Assessment:
I. Identification: Fill each Blank with correct answer. Write your answer on the space provided before the
number.
______________ 1. This technique mimics the natural process that creates identical twin. It is carried out in a
petri dish instead of inside the mother.
______________ 2. Produces copies of genes or segments of DNA.
______________ 3. First cloned mammals.
______________ 4. Produces embryonic stem cells for experiments aimed at creating tissues to replaced
injured or diseased tissues.
______________ 5. _________________ 6. ________________7. Risk of cloning.
______________ 8. Produces copies of whole animals.
______________ 9. Are organisms that are exact genetic copies.
______________ 10. The first idea of cloning
______________ 11. Dolly was created in a process called __________________.
______________ 12. Breaking a part a strand of DNA.
______________ 13. Selecting out the cells that were successfully transfected with the new DNA
______________ 14. Inserting the newly formed pieces of DNA into cells.
______________ 15. Gluing together pieces of DNA in a desired sequence.
_____________ 16. _________________ 17. The scientist who created the first cloned mammals.
_____________ 18. It is used to generate an animal that has the same nuclear DNA as another currently or
previously existing animal.
_____________ 19. Also known as DNA cloning.
_____________ 20. In a year 2002 a mice cloned from ______________________.
PREPARED BY:
Landagan, Richard P.
Camacho, Sachiko N.

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Copy Cat

(A lesson plan on Cloning)

a. Kumar, Dinesh. (2018). Retrieved from https://www.slideshare.net/mobile/dineshbhati5209000/cloning-

For activating prior knowledge and the whole setup: Laptop, TV

Activating Prior Knowledge

1|BTCH1 – Introduction to Biotechnology

1. Based on our activity, can you define what is cloning

2|BTCH1 – Introduction to Biotechnology

3|BTCH1 – Introduction to Biotechnology

4|BTCH1 – Introduction to Biotechnology

5|BTCH1 – Introduction to Biotechnology

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