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    Biol 243 Tert Assignment w19

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    rtm haider
    This document outlines a take-home assignment for a human genetics course assessing students' understanding of the human telomerase (TERT) gene. The assignment requires students to answer multiple choice questions about how alleles cause phenotypic variation and how differences in the wild type and PR228 alleles of TERT could increase mRNA production in the PR228 allele. Students must submit their typed responses in PDF format by the assigned deadline.

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    Biol 243 Tert Assignment w19

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    rtm haider
    153 views3 pages
    This document outlines a take-home assignment for a human genetics course assessing students' understanding of the human telomerase (TERT) gene. The assignment requires students to answer multiple choice questions about how alleles cause phenotypic variation and how differences in the wild type and PR228 alleles of TERT could increase mRNA production in the PR228 allele. Students must submit their typed responses in PDF format by the assigned deadline.

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    Assignment by university of calgary for practice

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    This document outlines a take-home assignment for a human genetics course assessing students' understanding of the human telomerase (TERT) gene. The assignment requires students to answer multiple choice questions about how alleles cause phenotypic variation and how differences in the wild type and PR228 alleles of TERT could increase mRNA production in the PR228 allele. Students must submit their typed responses in PDF format by the assigned deadline.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    153 views3 pages

    Biol 243 Tert Assignment w19

    Uploaded by

    rtm haider
    This document outlines a take-home assignment for a human genetics course assessing students' understanding of the human telomerase (TERT) gene. The assignment requires students to answer multiple choice questions about how alleles cause phenotypic variation and how differences in the wild type and PR228 alleles of TERT could increase mRNA production in the PR228 allele. Students must submit their typed responses in PDF format by the assigned deadline.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    BIOL

    243: Human TERT Take-Home Assignment (2019) – 3% of course grade

    Molecular Genetic Analysis of the Human Telomerase (TERT) Gene


    (Due on Wednesday February 13th before 4:00 PM)

    The purpose of this take-home assignment is to review and reinforce some of the concepts of
    molecular genetics learned in BIOL 243 and to develop critical thinking skills

    Instructions:
    • Type your answers to the following questions. Your responses must be double-spaced with
    12-point Times, Times New Roman or Cambria font. Although there is no page limit for this
    assignment, your responses should be concise and clearly answer each question.
    • Your assignment must be in PDF format and uploaded to the D2L (digital) Dropbox
    prior to 4:00 PM on Wednesday February 13th.
    • Do not submit this question sheet with your assignment
    • Contact Dr. Chua if you have any questions about this assignment
    • The work that you submit must be your own original work in your own words. Submissions
    that are identical or very similar are not acceptable and all suspected cases of academic
    misconduct are reported to the Head of the Department. See the University Calendar for more
    information on academic misconduct.

    Background Information:

    Telomeres are single-stranded DNA sequences located at the 3’ ends of eukaryotic


    chromosomes. They are repetitive noncoding DNA sequences (5’-TTAGCCC-3’) that play a
    critical role in protecting the ends of chromosome during DNA replication. The synthesis of
    telomeres at the 3’ ends of linear chromosomes is carried out by a reverse transcriptase
    enzyme called telomerase. Telomerase synthesizes telomeric DNA by using an RNA template
    that is complementary to the repeated sequences of the telomere (Figure 1). In humans, the
    telomerase is encoded by the TERT gene. There are two alleles of the human TERT gene.
    One allele (referred as “+” or wild type) produces normal levels of TERT mRNA or protein
    in stem cells. In contrast, the other allele (referred as “PR228”) produces four times the
    normal level of TERT mRNA and protein in stem cells.

    Page 1 of 3
    BIOL 243: Human TERT Take-Home Assignment (2019) – 3% of course grade

    Questions:

    Q1. According to the central dogma of molecular biology, explain how alleles cause
    phenotypic variation. Your answer should also include the definition of alleles. (4 marks)

    Page 2 of 3
    BIOL 243: Human TERT Take-Home Assignment (2019) – 3% of course grade

    Q4. Closer examination of the wild type and PR228 alleles of the human TERT gene reveals
    no changes in nucleotide sequence in the transcriptional unit. This observation indicates
    that the difference in nucleotide sequence between the two alleles must not occur within the
    transcriptional unit.

    Q4A. What is the transcriptional unit of the TERT gene? (2 marks)

    Q4B. Provide a possibility where nucleotide changes could occur on the chromosome in the
    PR228 allele that increases production of TERT mRNA and explain why. (3 marks)

    Q5. The PR228 allele of the TERT gene is commonly found in multiple types of cancers.
    Explain why. Your answer should not exceed 6 sentences. (4 marks)

    Page 3 of 3

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