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    In Vitro Drug Release Studies (24 Hours) Formulation Code PII Was Found To Be Better Than Other

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    Hilya
    The document summarizes research on developing a transdermal patch for hydrochlorothiazide (HCT) to improve its bioavailability and reduce dosing frequency. Three transdermal patch formulations were created using hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers. In vitro drug release studies found that formulation PII released the highest percentage of drug over 24 hours. Formulation PII was selected as the optimized patch as it followed Korsmeyer-Peppas, zero order, and Higuchi kinetic models. The optimized patch showed maximum drug permeation of 90.04% at 24 hours.

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    In Vitro Drug Release Studies (24 Hours) Formulation Code PII Was Found To Be Better Than Other

    Uploaded by

    Hilya
    21 views2 pages
    The document summarizes research on developing a transdermal patch for hydrochlorothiazide (HCT) to improve its bioavailability and reduce dosing frequency. Three transdermal patch formulations were created using hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers. In vitro drug release studies found that formulation PII released the highest percentage of drug over 24 hours. Formulation PII was selected as the optimized patch as it followed Korsmeyer-Peppas, zero order, and Higuchi kinetic models. The optimized patch showed maximum drug permeation of 90.04% at 24 hours.

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    The document summarizes research on developing a transdermal patch for hydrochlorothiazide (HCT) to improve its bioavailability and reduce dosing frequency. Three transdermal patch formulations were created using hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers. In vitro drug release studies found that formulation PII released the highest percentage of drug over 24 hours. Formulation PII was selected as the optimized patch as it followed Korsmeyer-Peppas, zero order, and Higuchi kinetic models. The optimized patch showed maximum drug permeation of 90.04% at 24 hours.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    21 views2 pages

    In Vitro Drug Release Studies (24 Hours) Formulation Code PII Was Found To Be Better Than Other

    Uploaded by

    Hilya
    The document summarizes research on developing a transdermal patch for hydrochlorothiazide (HCT) to improve its bioavailability and reduce dosing frequency. Three transdermal patch formulations were created using hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers. In vitro drug release studies found that formulation PII released the highest percentage of drug over 24 hours. Formulation PII was selected as the optimized patch as it followed Korsmeyer-Peppas, zero order, and Higuchi kinetic models. The optimized patch showed maximum drug permeation of 90.04% at 24 hours.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Nur Azizah

    145070500111002
    ABSTRACT
    Hydrochlorothiazide (HCT), thiazide diuretics, has comparatively short elimination half life,
    about 5.6 to 14.8 hours with bioavailability of 65-72%. the short half-life leads to increased
    frequency of drug use and decreased medication adherence. So as to enhance the bioavailability
    and to reduce the difficulties associated with HCT, it is decided to design a transdermal drug
    delivery system for this drug. Transdermal patches are used to deliver certain doses of drugs
    through the skin and into the bloodstream. Three formulations of Transdermal patches were
    fabricated by solvent evaporation technique using Hydroxy Propyl Methyl Cellulose polymer
    (HPMC), and Polyvinyl Pyrrolidone (PVP) to make the controlled release formulation. The
    prepared patches were wvaluated for their physicochemical characteristics and in-vitro drug
    release study. Physicochemical parameters like organoleptic, weight variation, thickness
    uniformity, and folding endurance were evaluated. In vitro permeation studies through snake
    skin were carried out using modified Franz diffusion cell. All the formulations exhibited
    satisfactory physicochemical characteristics. Among the formulations prepared, On the basis of
    in vitro drug release studies (24 hours) formulation code PII was found to be better than other
    formulation and it was selected as the optimized formulation. The results from in vitro drug
    release shows that the release of drug from patches increase with increase in concentration of
    HPMC. Drug release from optimized patch followed Korsmeyer-Peppas model zero and first
    order kinetic model, and higuchi model. The present study can be concluded that formulation
    code PII found to be the ideal patch, shown the maximum drug permeation of 90.04% at the end
    of 24 h followed Higuchi diffusion kinetics.

    Keywords : Transdermal patch, HCT, HPMC, PVP, Optimized, Franz diffusion cell
    ABSTRAK
    Hydrochlorothiazide (HCT), diuretik Thiazide, memiliki waktu paruh pendek, sekitar 5,6-14,8
    jam dengan bioavailabilitas 65-72%. waktu paruh yang pendek tersebut menyebabkan frekuensi
    peggunaan obat meningkat dan menyebabkan kepatuhan minum obat menurun. Jadi, untuk
    meningkatkan biovailabilitas dan mengurangi frekuensi penggunaan HCT, yaitu dengan
    menggunakan transdermal patch. Transdermal patch digunakan untuk menghantarkan obat
    dengan dosis tertentu melalui kulit dan masuk ke aliran darah. 3 formulasi Patch transdermal
    dibuat dengan teknik “solvent evaporation” menggunakan kombinasi polimer HydroxyPropil
    Metil Selulosa (HPMC) dan Polyvinyl Pyrrolidone (PVP) untuk membuat formulasi pelepasan
    terkontrol. Hasil patch dievaluasi untuk karakteristik fisikokimia dan studi pelepasan obat in-
    vitro. Parameter fisiko - kimia seperti organoleptis, keseragaman bobot, ketebalan, dan daya
    lipat. Penelitian difusi in vitro dilakukan melalui kulit ular dengan menggunakan Franz diffusion
    cell. Semua formulasi tersebut menunjukkan karakteristik fisikokimia yang memuaskan.
    Diantara formulasi yang dihasillkan, berdasarkan studi pelepasan obat in vitro (24 jam), kode
    formulasi PII ternyata lebih baik dari formulasi lainnya dan dipilih sebagai formulasi yang
    optimal. Laju difusi semua formulasi menunjukkan bahwa laju difusi mengalami penurunan
    ketika konsentrasi HPMC diturunkan. Laju pelepasan obat patch dioptimasi mengikuti
    Korsmeyer-Peppas model, zero dan first order kinetic model, dan higuchi model. Penelitian ini
    dapat disimpulkan bahwa patch transdermal dengan code PII adalah sebagai patch yang ideal
    dan optimum, ditunjukkan dengan permeasi obat maksimum 90,04% pada akhir 24 jam
    mengikuti Higuchi diffusion kinetic.

    Kata kunci : Transdermal patch, HCT, HPMC, PVP, optimum, Franz diffusion cell

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