MEDICINE

REVIEW ARTICLE

Rehabilitation After Stroke

Stefan Knecht, Stefan Hesse, and Peter Oster

ach year in Germany, 200 000 persons sustain

SUMMARY
Background: Stroke is becoming more common in Ger-
E their first stroke, and another 60 000 sustain a
stroke after one or more prior strokes; roughly one
many as the population ages. Its long-term sequelae can citizen in five will have a stroke at some time in his or
be alleviated by early reperfusion in stroke units and by
her life (1, 4). About 80% of strokes are ischemic, and
complication management and functional restoration in
20% are hemorrhagic (2). More than a quarter of stroke
early-rehabilitation and rehabilitation centers.
patients are under age 65 (3).
Methods: Selective review of the literature. Better preventive care is needed for the vascular
Results: Successful rehabilitation depends on systematic diseases underlying stroke, including the detection of
treatment by an interdisciplinary team of experienced risk factors (hypertension, smoking, lack of exercise,
specialists. In the area of functional restoration, there has overweight, and other risk factors), treatment with
been major progress in our understanding of the physiol- appropriate medications, and help with the necessary
ogy of learning, relearning, training, and neuroenhance- accompanying changes in lifestyle. Acute stroke treat-
ment. There have also been advances in supportive phar- ment in Germany, on the other hand, is relatively better
macotherapy and robot technology. developed.
Conclusion: Well-organized acute and intermediate reha-
bilitation after stroke can provide patients with the best
Initial care in stroke units
At present, 45% to 50% of all patients with acute stroke
functional results attainable on the basis of our current
scientific understanding. Further experimental and clinical
in Germany are treated in stroke units in which treat-
studies will be needed to expand our knowledge and ments that establish reperfusion can be provided and
improve the efficacy of rehabilitation. acute complications managed (4). Ideally, the stroke
unit infrastructure enables the rapid reopening of oc-
►Cite this as: cluded cerebral vessels, with immediate restoration of
Knecht S, Hesse S, Oster P: Rehabilitation after stroke. brain function. Because of the accompanying circum-
Dtsch Arztebl Int 2011; 108(36): 600–6. stances, however—in particular, the latency from the
DOI: 10.3238/arztebl.2011.0600 onset of symptoms to the initial examination by a
neurologist—only 7% to 10% of stroke patients cur-
rently undergo thrombolysis (4).
More than half of the patients admitted to a stroke
unit with an acute stroke can be discharged directly
home after treatment. Fewer than 5% of them die (4).
About 5% are highly unlikely to recover from their
stroke because of its severity, because they are very old
or severely demented, or because of accompanying ill-
nesses, such as cardiac or renal failure; for such pa-
tients, only nursing care and palliative measures are in-
dicated (5). More than 25% of patients are markedly
functionally disabled when they are ready to be dis-
charged from acute care and therefore stand to benefit
from early rehabilitation and rehabilitation (4).

Determinants of functional recovery

The site, extent, and nature of the stroke (ischemic vs.
hemorrhagic) are the main determinants of functional
recovery. Recovery is hindered above all by the in-
volvement of major white-matter tracts and by damage
or disconnection of the hippocampus, a structure that
Neurologische Universitätsklinik Münster: Prof. Dr. med. Knecht
plays a key role in the learning and relearning of neur-
Medical Park Humboldtmühle Berlin und Neurologische Rehabilitation, Charité
Universitätsmedizin Berlin: Prof. Dr. med. Hesse ological functions (6).
Geriatrisches Zentrum Agaplesion Bethanien-Krankenhaus Heidelberg:
In general, neurological function recovers less well
Prof. Dr. med. Oster in the elderly, though many very old persons recover

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FIGURE 1 TABLE

Complication rates of strokes that require early

rehabilitation (based on [13])

Complication
Overall 60–90%
Impaired regulation of breathing 20–60%
Dysphagia 35–70%
Aspiration pneumonia 10–20%
Urinary tract infection 10–30%
Pain 15–40%
Depression 15–25%
Simplified diagram of the time course of susceptibility to compli- Recurrent stroke 5–30%
cations and of functional recovery during rehabilitation after stroke.
The phases of rehabilitation (A–D) are indicated below. Epileptic seizures 10%
Myocardial infarction 2–6%
Congestive heart failure 3–10%
Cardiac arrest / arrhythmia 2–8%
surprisingly well from a stroke. The decisive factor Gastrointestinal hemorrhage 3–5%
here is the brain’s reserve capacity, i.e., the absence of
pre-existing damage in the form of subclinical vascular Deep vein thrombosis (lower limb) 2–4%
lesions. Accordingly, persons who had led an active Decubitus ulcer 1–4%
lifestyle till just before the stroke (7) and those with no Pulmonary embolism 1%
more than a minor degree of leukoaraiosis (pre-existing
white-matter damage) have been found to recover par-
ticularly well from stroke. In fact, the beneficial effect
of not having leukoaraiosis is of comparable magnitude
to that of thrombolysis. Thus, pre-existing brain
damage is more important than age as a determinant of Thanks to modern stroke unit care and neurological
the chance of recovery (8). intensive-care medicine, 20% more patients survive
their strokes today than 20 years ago, but those who
Available types of rehabilitation survive are also more severely affected early on than
Another relevant factor for the success of rehabilitation their historical counterparts (10). These patients’ out-
after stroke is the available infrastructure for rehabili- come depends nearly entirely on the prevention and
tative care. In Germany, a stepwise (phased) model of management of complications, notably (Table):
rehabilitation for stroke patients prevails, as recom- ● impaired control of breathing
mended by the Nationwide Rehabilitation Task Force ● dysphagia
(Bundesarbeitsgemeinschaft für Rehabilitation); in this ● aspiration pneumonia
model, the available broad spectrum of rehabilitative ● recurrent stroke
measures can be exploited to a greater or lesser extent, ● urinary tract infection
partially or sequentially, depending on the patient’s in- ● sugar and electrolyte disturbances
dividual needs (Figure 1). Emergency care in a stroke ● cardiac arrhythmia
unit is called Phase A, while early neurological reha- ● thrombosis.
bilitation constitutes Phase B of treatment and rehabili- The early Scandinavian experience revealed that
tation, characterized by a still high demand for medical stroke patients are more likely to make a good recovery
treatment (sometimes including intensive care). In if they are hospitalized in a stroke unit rather than on a
Phase C of post-stroke rehabilitation, patients can ac- general medical ward, even if they are not treated with
tively participate in their therapy but still need medical thrombolysis (11). The specialization and focusing of
treatment and nursing assistance. Phase D is the phase medical teams has markedly lowered the mortality and
right after early mobilization; strictly speaking, this morbidity of acute stroke (9, 12). More empirical data
phase corresponds to the idea of rehabilitation in the are needed before we can say whether the same holds
narrower definition of post hospital curative treatment. true for early neurological rehabilitation.
Phase E consists of occupational reintegration, Phase F Functional recovery is based on the restitution of
of continuing measures to support, maintain, or im- brain tissue and on the relearning of, and compensation
prove function. for, lost functions. Brain tissue restitution involves an
In the early phase after stroke, the patient’s progno- interlinked cascade of biological processes (Figure 2)
sis is determined mainly by potential complications due (14, 15). It has not yet been directly observed in man;
to the disturbance of elementary brain functions (9). we thus do not yet know how variable it is from one

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Phases and levels FIGURE 2

of brain tissue res-
toration and func-
tional restitution
after stroke (RF =
receptive fields)

patient to the next, to what extent it can be influenced trials have been carried out to date. On the other hand,
by current modes of treatment, and whether it might be small-scale controlled trials can point to the basic prin-
promoted by specific drug therapy with inflammatory ciples underlying functional recovery. Such trials have
modulators, growth factors, or other agents. The spon- shown that the main factors affecting outcome are
taneous restitution of brain tissue takes time and is the individual adaptation of therapy and the intensity and
underlying mechanism for the recovery of wakefulness, frequency of training (18).
attention, swallowing, and mobility that is often
observed over weeks after a stroke. The recovery of motor function
Lost functions can be compensated for or relearned The rehabilitation of walking
after stroke because of the complexity and plasticity of In our experience, various formalized physiothera-
the human brain. The complexity of the brain, with peutic methods, such as proprioceptive neuromuscular
over one trillion specified synaptic nerve connections, facilitation or the methods of Bobath and Vojta, are all
is genetically determined only in its coarse structure about equally effective (19). All are based on the
(16). At a finer level, synapses are specified by a pro- transfer of learned performance from one motor task to
cess of plastic adaptation that depends on interaction another. The Bobath method, for example, involves in-
with the environment. Thus, for example, the part of the tensive preparatory training for walking in the sitting
brain that normally becomes the visual cortex can grow and standing positions. In the rehabilitation of stance
to subserve language or tactile perception if visual and gait, a task-specific repetitive approach is increas-
input is lacking during development because of con- ingly being used in addition to conventional therapeutic
genital blindness (17). While complexity enables func- approaches: i.e., the motor task to be learned must be
tional compensation, the inherent adaptive plasticity of practiced by repeating it as many times as possible.
the system enables functional reorganization. Relearn- We recommend organizing the temporal course of
ing and compensation are intertwined. Functional rehabilitation in three transitional phases with different
recovery benefits from stepwise training, beginning goals, corresponding to the patient’s deficit at the time
with simple and supported functions and moving on- of each phase:
ward to complex and increasingly automatic sensori- ● the bedridden patient is mobilized out of bed;
motor interactions. Large-scale randomized and ● the patient, having been mobilized into a wheel-
controlled trials of specific modes of therapy are hard chair, learns to walk again;
to conduct, both because of the heterogeneity of func- ● the patient, having regained the ability to walk,
tional disturbances after stroke (site and extent of learns to do so rapidly and steadily, also under the
lesions, degree of pre-existing brain damage, and sever- prevailing conditions of everyday life.
ity of neurological deficit) and because of the difficulty Very early mobilization of stroke patients has been
of recruiting patients; thus, no more than a few such shown to lead to significantly better functional

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recovery. Thus, one should try to reach the concisely

stated goal “Out of bed!” within two days, as long as
the patient is hemodynamically stable (20). Mobili-
zation over the edge of the bed into a wheelchair, with
repeated practicing of transfers, should be supple-
mented by training in how to drive a wheelchair and
how to stand up at a standing desk, in order to prevent
functional impairment through contraction of the hip
and knee flexors. Further benefits of verticalization are:
● circulatory training,
● prevention of pneumonia and venous thrombosis,
● stimulation of the autonomic nervous system,
● sensory activation through standing.
Once the patient, having been mobilized out of the
wheelchair, can sit at the edge of the bed and can toler-
ate verticalization for at least ten minutes, the training
of ambulation can begin.
The number of footsteps practiced per training
session appears to be essential, whichever particular
method is used. The physical work needed to practice
a large number of steps is, however, difficult for
physiotherapists to carry out unaided, and thus gait-
training machines are recommended for this purpose
(Figure 3). The machine enables the patient, wearing a
safety belt, to practice walking over and over again. It
does not replace the physiotherapist, but the combi-
nation of the machine and the physiotherapist is more
effective than the latter alone and can prevent one-
quarter of all cases of inability to walk that would
otherwise ensue (21). Figure 3: Robot-assisted gait training in a virtual environment. The system enables early
Severe arthrosis in the lower limbs, congestive verticalization of the patient and an early start of gait training, with a continuous transition
heart failure, or a markedly abnormal spastic posture from mainly robot-initiated to increasingly independent movement. (Photograph by Roland
Magunia)
of the joints requires either specific treatment or else
reduction of the intensity of physiotherapy. If the pa-
tient suffers from spastic pes equinus, with a twisted
food and claw toes, timely treatment with a splint or
intramuscular injection of botulinum toxin is recom- induced movement therapy is a treatment option for the
mended. Specialized centers offer the further option chronic phase that has been found effective in multiple
of surgical myotendolysis, which enables wider open- scientific studies. It involves binding the unaffected
ing of a joint once contractures have formed. If the hand and intensively practicing the use of the affected
patient can walk a short distance independently, using one in small group sessions (24).
a mechanical aid, then the steadiness, speed, and It is much harder to rehabilitate an upper limb that is
maximal duration of gait can all be improved. These so severely effected that the hand—in particular, the
are the important characteristics of gait for everyday wrist and finger extensors—remain plegic four to six
life. weeks after the stroke, so that the patient can carry out
no more than synergistic movements of the shoulder
The rehabilitation of arm and hand function and elbow. In such cases, the limb should be positioned
Some 80% of stroke patients suffer from upper limb and passively mobilized so as to prevent shoulder pain
paresis. Those who are less severely affected can begin (never lift the arm by simply picking up the hand!) and
to move their fingers again in the first four to six weeks spastic flexor posture. The benefit of physiotherapy for
after the stroke and rapidly regain the ability to extend restoring arm and hand function is debated. The prob-
the wrist and fingers actively. This is a strong predictor ability of restoring useful hand function for everyday
of the restoration of hand function (22). Physiothera- life six months after the stroke is less than 5% (25). If
pists try to train the patient’s returning arm and hand the decision is made to pursue physiotherapy, it should
function with repetitive practice, paying special atten- be begun early. If weakness is so severe that active ther-
tion to strength, coordination, and speed, and to apy is not possible, then passive or assistive therapy
integrate hand function into the patient’s everyday should be provided by an experienced therapist, with
activities (23). Learned non-use of the limb (because the use of facilitation techniques. Isolated movements
the other hand is much faster and more accurate) should are repetitively practiced. Alternatively, robots and
be watched for. If it should arise, so-called constrained mechanical apparatus can be used (e1, e2). Two types

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BOX with respect to attention and memory, often limit the

patient’s autonomy, even if the patient does not
perceive this (e6). Neuromodulation, which will be
Common complications of stroke in discussed in the next section, can be used in such situ-
elderly patients* ations alongside targeted neurocognitive training.
● Falls (particularly common after discharge from acute
hospital care) Neuromodulation
Neuroenhancement is the use of drugs or electrical
● Incontinence (urinary, fecal) stimulation to improve wakefulness, mood, and learn-
● Delirium / development of dementia ing ability to further enhance functional recovery after
● Depression / anxiety disorders stroke. The underlying principle is that the processing
of incoming stimuli by the central nervous system is
● Dysphagia / aspiration pneumonia normally modulated according to their significance for
● Pulmonary embolism / thrombosis the organism. Significant contexts are those that are
linked to attention, emotion, novelty, or reward. When
● Psychosocial problems incoming stimuli are monotonous, the activity level of
● Drug side effects and interactions the ascending brainstem pathways declines. Because
these pathways function, in part, through the use of
* that are observed in clinical practice typical neurotransmitters such as noradrenaline and
dopamine, their modulating effects on learning can be
reproduced by the exogenous administration of these
transmitters or their precursors. In this way, brainstem
activation that is slowly declining, or that has been
of therapy are currently established for use in the impaired by brain damage, can be compensated for or
chronic phase: even driven to supranormal levels. Initial randomized
● constrained induced movement therapy, described clinical trials have yielded promising results (e7–e9),
above, for patients who can voluntarily extend which, however, still need to be confirmed in further
their wrist and finger joints; studies (e10). Multiple clinical trials of transcranial
● botulinum toxin injections to treat spastic flexion, direct-current (DC) stimulation to facilitate functional
with the aim of reducing muscle tone, facilitating recovery after stroke are now in progress (e11).
hand care, and alleviating pain.
Special considerations for elderly patients
The recovery of cognitive function Stroke is also a classic disease of old age. The more
Neurocognitive functional recovery involves con- functionally relevant comorbidities the patient has, the
sciousness, attention, language, memory, and planning; clearer the indication for geriatric rehabilitation. Nearly
these are complex, adaptive functions with correspond- all patients aged 80 and above undergo geriatric reha-
ingly complex and dynamic neural substrates. Here, bilitation.
too, the relevant factors for recovery are time and After acute treatment for stroke, elderly patients can
stepwise training, which we shall illustrate through the undergo either a complex early rehabilitative geriatric
example of language training. One-third of all stroke treatment in an acute hospital or else a course of
patients suffer from aphasia, and two-thirds of these geriatric rehabilitation, which, unlike specialized neu-
have a permanent language deficit of greater or lesser rological rehabilitation for younger stroke patients, is
severity (e3). Five or more hours of speech therapy per not divided into phases. The multimodal and multidis-
week are associated with significantly better functional ciplinary treatment plan for the patient’s functional
recovery than the spontaneous course after stroke (e4). deficits is established on the basis of the geriatric
Speech therapy can be conducted at the level of words, assessment. Secondary stroke prevention, particularly
sentences, or conversations. Functional improvement is through increased exercise, is not merely indicated, but
usually limited to the particular area practiced and can actually especially effective in the elderly, who have a
be lost if maintenance training is not kept up. If the higher incidence of stroke than younger patients do.
patient’s condition allows more complex pragmatic Nonetheless, treatment recommendations for elderly
communication situations to be trained, this may con- patients are still based on extrapolation from the find-
tribute, by way of improved strategies, to an indirect ings of trials carried out on younger patients (e12).
generalization of the effect of training. Relevant scientific data are particularly scarce for
The goal of all rehabilitative treatments is to achieve patients in advanced old age.
the greatest possible autonomy and, ideally, complete Brain plasticity basically remains intact into old age.
psychosocial reintegration for the patient. Some 40% of Problems arise, however, through comorbidities such as
stroke patients who undergo rehabilitation can re-enter congestive heart failure and diabetes, and through the
the working world afterward (e5). Motor deficits play patient’s functional limitations—physical, mental,
only a moderate role in determining whether the patient emotional, and psychosocial. Stroke complications are
can return to work, while cognitive deficits, particularly more common in old age, and confer a worse prognosis

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(Box). Precise data are unavailable, as these effects Manuscript submitted on 5 October 2010; revised version accepted on
21 March 2011.
depend both on the severity of the stroke and on the
extent of pre-existing damage.
Because the structure of ambulatory care has im- Translated from the original German by Ethan Taub, M.D.
proved in recent years, early hospital discharge pro-
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Corresponding author
Prof. Dr. med. Stefan Knecht
Neurologie
Universitätsklinikum Münster
D-48129 Münster, Germany
[email protected]

@ For eReferences please refer to:

www.aerzteblatt-international.de/ref3611

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REVIEW ARTICLE

Rehabilitation After Stroke

Stefan Knecht, Stefan Hesse, and Peter Oster

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