Indian J Med Res. 2013 Feb; 137(2): 251–269.

PMCID: PMC3657849

PMID: 23563369

Chronic obstructive pulmonary disease

V.K. Vijayan*

Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India**

*
Reprint requests: Dr V.K. Vijayan, Advisor, Bhopal Memorial Hospital & Research Centre Raisen By-
Road, Bhopal 462 038, India e-mail: moc.liamtoh@kvnayajiv, Present address: Advisor to Director
General, ICMR Bhopal Memorial Hospital & Research Centre & National Institute for Research in
Environmental Health, Bhopal
**
Former Director

Received 2012 Nov 6

Copyright : © The Indian Journal of Medical Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-
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Abstract

The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults
aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma,
Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic
bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk
factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed
in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes
proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance,
systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a
postbronchodilator FEV1 (forced expiratory volume in 1 sec) to FVC (forced vital capacity) ratio <0.70.
COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are
cardiovascular disorders (coronary artery disease and chronic heart failure), hypertension, metabolic
diseases (diabetes mellitus, metabolic syndrome and obesity), bone disease (osteoporosis and
osteopenia), stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive
decline. The assessment of COPD is required to determine the severity of the disease, its impact on the
health status and the risk of future events (e.g., exacerbations, hospital admissions or death) and this is
essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral
theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes
smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery
and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis,
management and prevention of Chronic Obstructive Pulmonary Disease guidelines recommend
influenza and pneumococcal vaccinations.

Keywords: Airflow limitation, air pollution, bronchodilators, chronic obstructive pulmonary disease,
exacerbations, lung, pulmonary rehabilitation, smoking

Introduction

Chronic obstructive pulmonary disease (COPD) is a name coined for the diseases that were previously
known as chronic bronchitis and emphysema. The British Medical Research Council (BMRC) defined
chronic bronchitis as “daily productive cough for at least three consecutive months for more than two
successive years1. American Thoracic Society (ATS) in 1962 defined emphysema as an “anatomic
alteration of the lung characterized by an abnormal enlargement of the air spaces distal to the terminal,
non-respiratory bronchiole, accompanied by destructive changes of the alveolar walls”2. The definition
of emphysema put forth by the National Heart, Lung and Blood Institute in 1984 is as “a condition of the
lung characterized by abnormal, permanent enlargement of airspaces distal to the terminal bronchiole,
accompanied by the destruction of their walls, and without obvious fibrosis”3. Reid reported that “the
diagnosis of emphysema by itself is incomplete unless it is taken into account the presence or absence
of chronic bronchitis and vice versa”4. McDonough et al5 have recently reported extensive obliteration
of terminal bronchioles in patients with COPD who have emphysema, suggesting that “the permanent
enlargement of the distal airspaces may serve only as a structural biomarker, being a secondary result of
small airway inflammation and destruction”6. Thus, COPD has both airway (central and small airways)
and airspace abnormalities. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recently
defined COPD as “a common preventable and treatable disease characterized by persistent airflow
limitation that is usually progressive and associated with an enhanced chronic inflammatory response in
the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to
the overall severity in individual patient7”. It is worthwhile to mention that William Osler in 1892 in his
“Textbook of Medicine” has described hypertrophic emphysema as “a well-marked clinical affection,
characterized by enlargement of the lungs due to distension of the air cells and atrophy of their walls,
and clinically by imperfect aeration of the blood and more or less dyspnea”8, a beautiful clinical
description of emphysema.

Epidemiology

(i) Global scenario

There are wide variations in the prevalence of COPD across countries. This variation in the estimated
prevalence is due to the method of diagnosis and classification of COPD9. It has been observed that the
prevalence estimates were higher when COPD has been diagnosed by spirometry compared with
methods using symptoms10. COPD is common in older population and is highly prevalent in those aged
more than 75 yr. The global prevalence of physiologically defined chronic obstructive pulmonary disease
(GOLD stage 2 or more) in adults aged ≥40 yr is approximately 9-10 per cent11. The Burden of
Obstructive Lung Disease (BOLD) study from 12 sites involving 9425 subjects who had completed post
bronchodilator spirometry testing found that the overall prevalence of COPD of GOLD stage II or higher
was 10.1 per cent and the prevalence was 11.8 per cent for men and 8.5 per cent for women12. This
study had also revealed that there were differences between countries, the prevalence ranging from 9
per cent in Reykjavik, Iceland to 22 per cent in Cape Town, South Africa for men and from 4 per cent in
Hannover, Germany to 17 per cent in Cape Town for women. The multicentre PLATINO study that
described the burden of COPD in five Latin American countries using post-bronchodilator spirometry
had reported that the prevalence of airway obstruction was 14.3 per cent and the proportion of subjects
in stages II- IV of the GOLD classification was 5.6 per cent13. The reported prevalence of COPD in China
varied between 5 and 13 per cent in different provinces/cities14.

(ii) Indian scenario

One of the earliest studies to know the prevalence of COPD in India was carried out by Wig et al in
196415 in rural Delhi. The prevalence was 3.36 per cent in males and 2.54 per cent in females in this
study. Viswanathan in 196616 reported 2.12 per cent prevalence in males and 1.33 per cent in females in
Patna. Radha and colleagues18 noticed that the prevalence in New Delhi in 1977 was 8.1 per cent in men
and 4.6 per cent in women17. Jindal in 199318 reported that the prevalence was 6.2 per cent in men and
3.9 per cent in women in rural area, and 4.2 and 1.6 per cent, respectively in urban area. All these
studies were from north India and information from south India was scanty. Thiruvengadam et al in
197719 from Madras (south India) reported the prevalence of COPD of 1.9 per cent in males and 1.2 per
cent in females. However, Ray et al in 199520 from south India found that the prevalence was 4.08 per
cent in males and 2.55 per cent in females. Recently, the Indian Study on Epidemiology of Asthma,
Respiratory Symptoms and Chronic Bronchitis in Adults (INSEARECH) involving a total of 85105 men,
84470 women from 12 urban and 11 rural sites was reported21. This study had shown that the overall
prevalence of chronic bronchitis in adults >35 yr was 3.49 per cent (ranging 1.1% in Mumbai to 10% in
Thiruvananthapuram). Thus there are wide variations in the prevalence of COPD in India subcontinent.
Based on this study, the national burden of chronic bronchitis was estimated as 14.84 million.

Risk factors

The development of COPD is multifactorial and the risk factors of COPD include genetic and
environmental factors. The interplay of these factors is important in the development of COPD.

(i) Genetic factors

Alpha1-antitrypsin deficiency is an established genetic cause of COPD especially in the young and it has
been reported that α1-antitrypsin deficiency occurs in 1-2 per cent of individuals with COPD22. Alpha1-
antitrypsin is mainly produced in the liver and normal alpha1 antitrypsin is due to the M allele. Severe
alpha1-antitrypsin deficiency results from mutation in the SERPINA 1 gene [located on the long arm of
chromosome 14 (14q31-32.3)] and this gives rise to the Z allele23.

Genome-wide association (GWA) study has identified three loci (CHRNA3/CHRNA5/IREB2, HHIP, and
FAM13A) that are associated with COPD susceptibility24–26. A new COPD locus has also been identified on
chromosome 19q13, which harboured the RAB4B, EGLN2, MIA, and CYP2A6 genes27. GWA study on
forced expiratory volume in 1 second (FEV1) and FEV1/FVC (forced vital capacity) ratio has identified five
genome-wide significant loci for pulmonary function, three [2q35 (TNS1), 4q24 (GSTCD), and 5q33
(HTR4)] for FEV1, and two for FEV1/FVC [6p21 (AGER) and 15q23 (THSD4)28. Another GWA study found
significant associations with FEV1/FVC ratio for SNPs located in seven previously unrecognized loci: 6q24
(GPR126), 5q33 (ADAM19), 6p21 (AGER and PPT2), 4q22 (FAM13A), 9q22 (PTCH1), 2q36 (PID1), and
5q33 (HTR4). One new locus for FEV1 on 4q24 annotated by three genes (INTS12, GSTCD, and NPNT)
was identified for FEV128. 4q24 (GSTCD), 5q33 (HTR4) and 6p21 (AGER) were common in both
studies28,29. The first GWA study on lung-function decline has recently reported one locus on
chromosome 13q14.3 containing the DLEU7 gene that is strongly associated with FEV1 decline30.

(ii) Environmental factors

Tobacco smoking is the main cause of obstructive pulmonary disease31. Other important environmental
factors associated with COPD are outdoor air pollution, occupational exposure to dusts and fumes,
biomass smoke inhalation, exposure to second-hand smoke and previous tuberculosis32.

(a) Tobacco smoking: Though tobacco smoking is the most important cause of COPD, the population-
attributable fraction for smoking as a cause of COPD ranged from 9.7 to 97.9 per cent32. A Swedish
cohort study had observed that population-attributable fraction for smoking as a cause of COPD was
76.2 per cent33. In another Denmark study, the reported population-attributable fraction as a cause of
COPD was 74.6 per cent34. Thus, a significant proportional subjects with COPD had causes other than
tobacco smoking. In our country, bidi smoking is an important factor in addition to cigarette smoking
that causes COPD35.

(b) Outdoor air pollution: Outdoor air pollution mainly from emission of pollutants from motor vehicles
and industries is an important public health problem36. In a community-based study, it has been
observed that higher traffic density was significantly associated with lower FEV1 and FVC in women37. In
the Danish Diet, Cancer and Health cohort study involving 57,053 participants, it has been shown that
COPD incidence was significantly associated with nitrogen dioxide levels38. Particulate pollutants, ozone
and nitrogen dioxide can produce bronchial hyper reactivity, airway oxidative stress, pulmonary and
systemic inflammation36. However, a causal relationship between outdoor air pollution and COPD is still
not established.

(c) Indoor air pollution: Important indoor air pollutants are environmental tobacco smoke, particulate
matter, nitrogen dioxide, carbon monoxide, volatile organic compounds and biological allergens37.
Among these, environmental tobacco smoke39,40 and biomass smoke exposure are related to the
development of COPD42. Globally, it has been estimated that about 2.4 billion people (about 50% of
world's population) use biomass fuel as the primary energy source for domestic cooking, heating and
lighting43. Biomass (wood, crop residue and animal drug) are burnt in rural areas using substandard
stoves in poorly ventilated indoors. Women, spending more time indoors for cooking than men, are
exposed to biomass fuel combustion products and are prone to develop COPD41,42,44. A meta-analysis has
shown that biomass smoke exposure was a risk factor for developing COPD in both women and men44.

(d) Other risk factors: Other risk factors associated with COPD and reduced FEV1 are occupational
exposure to dusts and fumes, previous tuberculosis, maternal smoking, childhood asthma and childhood
respiratory infections45.

Pathology

Pathological changes in COPD are observed in central airways, small airways and alveolar space46. Mucus
glands and goblet cells are found in the lining of trachea-bronchial tree in normal individuals and mucus
is produced by these cells. In chronic bronchitis patients, the mucus glands are enlarged and goblet cells
undergo metaplasia. The excess mucus secreted by these cells as a result of irritation from cigarette
smoke, air pollutants, etc. and cough are the cardinal features of chronic bronchitis. The size of the
mucus glands can be determined by the Reid index which is measured by calculating the ratio of
bronchial gland to the thickness of bronchial wall4. Narrowing and destruction of terminal bronchioles
(airways <2 mm in diameter) are characteristic changes in COPD. Small airways offer <20 per cent of the
total resistance below the larynx47 and the resistance of the small airways is increased 4- to 40-fold in
lungs from patients with COPD48. Thus, the small airways are the major site of increased resistance in
persons with COPD. The cellular events that occur in the small airways in COPD include replacement of
Clara cells with mucus-secreting and infiltrating mononuclear cells and goblet cell metaplasia46. Smooth
muscle hypertrophy is also an important finding. As a result of excess mucus secretion, oedema
formation and cellular infiltration and the resultant fibrosis cause airway narrowing. Pathological
changes that occur in alveolar space include accumulation of macrophages and neutrophils. There is also
an increase in T-lymphocytes particularly CD8+ T cells. Chronic inflammation and destruction of alveolar
space lead to either cetriacinar or panacinar emphysema.

Pathogenesis

The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological

mechanisms, oxidant-antioxidant balance,systemic inflammation, apoptosis and ineffective repair46.

(i) The proteinase-antiproteinase hypothesis

The proteinase-antiproteinase hypothesis is based on the assumption that tissue destruction and
emphysema occur due to an imbalance between the proteinases and their inhibitors. It has been
proposed that there is an increase in the quantity of elastic-degrading enzymes compared to their
inhibitors in emphysema. This concept has been suggested in emphysema that has been described in α1
antitrypsin (α1AT) deficiency, first reported by Laurell and Eriksson in 196349. The patients with α1AT
deficiency have mutations in the α1AT gene. Z mutation is the common mutation and these mutations
impair secretion of the protein from hepatocytes. As a result, there is markedly decreased circulating
level of serine proteinase inhibitor. PiZ-α1AT is less effective than the normal PiM-α1AT. It has been
recently reported that PiZ-α1AT is prone to polymerization which can inhibit hepatic secretion, impair
neutrophil elastase (NE) inhibition and promote inflammation46. Chronic cigarette smoke exposure leads
to accumulation of activated macrophages, neutrophils and CD8+ T lymphocytes in the distal airways
and alveolar spaces50. Macrophages and neutrophils are the main sources of proteases in lungs. Excess
neutrophil elastase produced by the activated neutrophils overwhelms the serine proteinase inhibitors
leading to the development of emphysema. Cigarette smoke also activates airway epithelium to trigger
airway remodelling51. Studies have demonstrated that there are correlations between the degree of
macrophage and neutrophil inflammation and severity of airflow obstruction52.

Matrix metalloproteinases (MMP), increased in many lung diseases including COPD, have the capacity to
cleave structural proteins such as collagen and elastin and these MMPs are linked to the pathogenesis of
COPD53. Increases in many MMPs are reported in smoking-related emphysema and three MMPs (MMP-
2, -9, and 12) are shown to degrade elastin53. MMP-9 and MMP-12 are expressed in alveolar
macrophages from COPD patients. Cigarette smoke causes macrophages to produce MMP-12 which can
cleave elastin into fragments. Elastin fragments are chemotactic to monocytes and fibroblasts and this
increases the inflammatory and protease burden in the lung and leads to subsequent lung destruction.
This creates a positive feedback loop that results in continuous destruction of lung parenchyma54. A
single-nucleotide polymorphism in MMP-12 has been identified as a protective factor for COPD55. Other
proteases that play important roles in COPD are cathapsins S, L (in macrophages), and G, and
proteinase-3 (in neutrophils)56. However, subsequent studies have unravelled a more complex
pathogenesis in emphysema57.

(ii) Immunological mechanisms

COPD is associated with an abnormal inflammatory response of the lungs to noxious particles or gases,
most commonly cigarette smoke7. Patients with COPD have been reported to have increased numbers
of neutrophils in sputum, lung tissue and bronchoalveolar lavage (BAL)58 and neutrophils are important
cells in the pathogenesis of COPD. Serum levels of immunoglobulin free light chains (IgLC) were found to
be increased in smoking-induced COPD59. IgLC were found to bind neutrophils and cross-linking of IgLC
on neutrophils results in increased production of IL8/CXCL8 which is a selective attractant of
neutrophils. B cells have been found to be increased in COPD and these cells produce IgCL, in addition to
IgG and IgA in COPD60. It has also been reported that serum IgE levels are increased in patients with
COPD and this may be related to smoking61. Both IgE and IgLC can exert similar proinflammatory effects
via neutrophils59. However, the role of immunoglobulins in the pathogenesis of COPD is not understood.

(iii) Oxidant-antioxidant balance

Abnormally accumulated inflammatory cells including neutrophils and macrophages and cigarette
smoke produce reactive oxygen species which play an important role in the pathogenesis of COPD.
Oxidative stress can impair vasodilation and endothelial cell growth. When the oxidant load exceeds the
antioxidant capacity of the lung, modification of proteins, lipids, carbohydrates and DNA occurs in the
local milieu resulting in tissue injury. Though the oxidants cannot degrade extracellular matrix, these can
modify elastin. Modified elastin is then more susceptible to proteolytic cleavage. Cigarette smoke can
inactivate histone deacetylase (HDAC2) and this leads to NF-kB-mediated transcription of neutrophil
chemokines/cytokines (TNF-α and IL-8) and MMPs. Neutrophil elastase and MMPs overwhelm their
respective inhibitors. This can augment the matrix-degrading capacity which can promote emphysema
formation46.

(iv) Systemic inflammation

In addition to the pulmonary component, COPD has several extrapulmonary manifestations. It has been
postulated that persistent pulmonary inflammation may promote the release of pro-inflammatory
chemokines and cytokines into the circulation62. These mediators can stimulate liver, adipose tissue and
bone marrow to release excessive amounts of leucocytes, C-reactive protein (CRP), interleukin (IL)-6, IL-
8, fibrinogen and tumour necrosis factor-α (TNF-α) into the circulation62,63. This may lead to a persistent
low-grade systemic inflammation62. Systemic inflammation may initiate or worsen comorbid diseases,
such as ischaemic heart disease, heart failure, osteoporosis, normocytic anaemia, lung cancer,
depression and diabetes64. Two Danish population studies involving 8656 COPD patients had revealed
that simultaneously elevated levels of CRP, fibrinogen, and leukocyte count were associated with a 2- to
4-fold increased risk of major comorbidities (myocardial infarction, heart failure, diabetes, lung cancer
and pneumonia) in COPD65.

(v) Apoptosis

Recent studies have highlighted that apoptosis is involved in the development of COPD and it has been
demonstrated that there is an increase in apoptotic alveolar epithelial and endothelial cells in the lungs
of COPD patients. Since this is not counterbalanced by an increase in proliferation of these structural
cells, the net result is destruction of lung tissue and the development of emphysema. It has been
suggested that there is a role for vascular endothelial growth factor (VEGF) in the induction of apoptosis
of structural cells in the lung. Other mediators involved in apoptosis are caspase-3 and ceramide51,66–68.

(vi) Ineffective repair

There is ineffective repair in emphysema and this is due to the limited ability of the adult lung to repair
the damaged alveoli. Studies have shown that treatment of normal rats with all-trans-retinoic acid
increases the number of alveoli and this prompted the investigators to study whether a similar effect
would occur in rats with emphysema. In experimentally produced emphysema in rats, it has been shown
that treatment with all-trans-retinoic acid reversed the changes associated with emphysema. A similar
effect in humans is a possibility69. Advances in regenerative medicine and stem cell biology may answer
some of these issues.

(vii) Endothelial microparticles

Pulmonary vascular disease is an important consequence of COPD. Endothelial microparticles (EMPs)

which are microvesicles released from apoptotic endothelial cells are increased in smokers with normal
spirometry and low diffusing capacity70. The majority of microparticles are angiotensin-converting
enzyme positive and this observation suggests that EMPs are of pulmonary vascular origin. EMPs can be
a potential biomarker for pulmonary vascular disease associated with COPD.

Pathophysiology

Pathophysiological changes in COPD are due to the pathological changes seen in central airways, small
peripheral airways, pulmonary parenchyma and pulmonary vasculature. Mucus hypersecretion is
common in patients with predominant central airway involvement. Chronic obstructive pulmonary
disease is characterized by an accelerated decline in FEV171. Airflow limitation in COPD is defined as a
postbronchodilator FEV1 (forced expiratory volume in 1 sec) to FVC (forced vital capacity) ratio <0.70,
usually without reversibility to bronchodilators. Bronchodilator reversibility and bronchial hyper-
reactivity are variable in COPD and, therefore, have limited value in distinguishing COPD from bronchial
asthma72. Overall 23 to 42 per cent of patients with COPD have responsiveness to bronchodilators and
59 per cent of men and 85 per cent of women with moderate COPD have airway hyper
responsiveness73,74. The severity of airflow limitation in COPD is classified based on post-bronchodilator
FEV1value into four groups (GOLD 1, GOLD 2, GOLD 3 and GOLD 4). In patients with FEV1/FVC <70, if
FEV1 >80 per cent predicted, they are classified as mild (GOLD 1), if FEV1 predicted < 80 per cent and ≥
50 per cent as moderate (GOLD 2), if FEV1 predicted <50 per cent and >30 per cent as severe (GOLD 3)
and if FEV1 predicted <30 per cent as very severe (GOLD 4) airflow limitation7. The Evaluation of COPD
Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study has shown that the rate of
decline in FEV1 over a 3-year period was highly variable76. In this study, the mean rate of change in FEV1
was a decline of 33 ml per year with significant variation and only 38 per cent of patients had an
estimated decline in FEV1 of more than 40 ml per year. The rate of decline in FEV1 in this study in more
than half of the patients was no greater than that observed in subjects without lung disease suggesting
that COPD is not invariably progressive. Current smokers, patients with bronchodilator reversibility, and
patients with emphysema had increased rates of decline in FEV175. The ECLIPSE study further observed
that Clara cell protein (CC-16) was significantly associated with a greater decline in FEV1 of 4 ± 2 ml per
year for each decrease in one standard deviation of the CC-16 level75. Patients with COPD have
pulmonary hyperinflation characterized by an increase in functional residual capacity and a decreased
inspiratory capacity. Patients with emphysema have low carbon monoxide diffusing capacity. Low
arterial oxygen and high carbon dioxide levels are observed in patients with COPD with respiratory
failure. Pulmonary arterial hypertension (PAH) develops late in the course of the natural history of
patients with COPD. This can be associated with the development of severe hypoxaemia and is a major
cardiovascular complication of COPD. Chronic pulmonary hypertension leads to the development of
right ventricular hypertrophy and cor pulmonale and has a poor prognosis76. Wells et al77 observed that
computerised tomography-detected pulmonary artery enlargement defined as a ratio of the diameter of
the pulmonary artery to the diameter of the aorta (PA: A ratio of >1) was independently associated with
acute exacerbations of COPD77.

Co-morbidities

Extrapulmonary manifestations in COPD, in addition to pulmonary component, are common. It has been
observed in the ECLIPSE study that comorbidities were significantly higher in patients with COPD than in
smokers and never smokers78. The important comorbidities associated with COPD are cardiovascular
disorders (coronary artery disease and chronic heart failure, hypertension), metabolic diseases (diabetes
mellitus, metabolic syndrome and obesity), bone disease (osteoporosis and osteopenia), stroke, lung
cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline79. Risk factors
such as advancing age, cigarette smoking and environmental pollution are common to both COPD and
ischaemic heart disease. The potential mechanisms of increased risk of cardiovascular disease in COPD
are systemic inflammation, increased oxidative stress, neurohumoral disturbances and increased
thrombotic tendency62. A systematic review of literature had shown that reduced FEV1 nearly doubles
the risk for cardiovascular mortality independent of age, sex and cigarette smoking80. It has been
reported that a 10 per cent decrease in FEV1 among COPD patients increases the cardiovascular event
rate 28 per cent81. COPD patients were 1.76 times more likely to have arrhythmias, 1.61 times more
likely to have angina, 1.61 times more likely to develop acute myocardial infarction and 3.84 times more
likely to develop congestive heart failure82. There was also an inverse relationship between lung function
and ischaemic stroke in subjects who had never smoked83. In a study of 12,04,110 patients aged >35 yr,
COPD patients (n=29870) were five times more likely to have a cardiovascular disease compared with
those without COPD (n=11,74,240)84. Analysis of data from 20,296 subjects aged ≥45 yr at baseline in
the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) has
revealed that subjects with GOLD stages 3 or 4 COPD had a higher prevalence of diabetes, hypertension
and cardiovascular disease85. Lucas-Ramos et al86 in a study of 1200 COPD patients and 300 control
subjects showed that the COPD group had a significantly higher prevalence of ischaemic heart disease,
cerebrovascular disease, and peripheral vascular disease. COPD, hypertension, diabetes, obesity, and
dyslipidaemia were risk factors for ischaemic heart disease in the univariate analysis. In the multivariate
analysis adjusted for the remaining factors, COPD was still an independent risk factor suggesting that
COPD patients had a high prevalence of cardiovascular disease, higher than expected given their age and
the co-existence of classic cardiovascular risk factors86.

Cachexia, defined as excessive weight loss is a frequent finding in COPD and is associated with poor
functional capacity and increased mortality. It has been observed that 10 to 15 per cent of patients with
mild to moderate COPD have significant weight loss whereas the weight loss is observed in 50 per cent
of patients with severe COPD87. It has been reported that fat-free mass is significantly reduced in
COPD61. The proposed mechanism of cachexia in COPD includes low testosterone levels, increased pro-
inflammatory cytokines and increased catecholamine synthesis88–90.

Skeletal muscle dysfunction due to loss of skeletal muscle mass occurs mainly in the thighs and upper
arms91. As a result of skeletal muscle dysfunction, patients with COPD have reduced exercise endurance
and present with symptoms of fatigue and dyspnoea92. There was significant reduction in type I fibres
and a relative increase in type II fibres in skeletal muscles of patients with COPD93. Reduced oxidative
energy metabolism as a result of the reduced cytochrome C oxidase and succinate dehydrogenase
activities has been reported in COPD94. Microscopic findings in skeletal muscles of COPD patients include
increased oxidative stress, lactic acidosis, increased apoptosis and inflammatory changes95.
Deconditioning and disuse are other factors that may contribute to skeletal muscle dysfunction. Use of
corticosteroids, poor nutrition and hormonal changes exaggerate muscle dysfunction in COPD96.
Another important comorbid condition in COPD is reduced bone mass. A strong correlation between low
bone mass and radiological emphysema has been reported in smokers97. The risk of osteoporosis
increases by 1.9-fold in patients with airway obstruction compared with those without airway
obstruction and by 2.4-fold in patients with severe COPD98. The proposed aetiology for the bone loss
includes smoking, vitamin D deficiency, low body mass index, hypogonadism, sedentary lifestyle, and
use of glucocorticoids99. Patients with COPD are vulnerable to fractures particularly vertebral
fractures100.

Epidemiological studies have suggested that the risk of lung cancer is higher in smokers with COPD
compared with smokers with normal lung function101,102. Previous lung diseases are also found to be
associated with an increased risk of lung cancer101. The annual-incidence rates of lung cancer per 10,000
person-years were at least four-fold higher in patients with prior COPD compared with the general
population102. A longitudinal study has revealed that there is high incidence density of lung cancer in
outpatients with COPD (16 per 1000 person- years compared with 1-1.5 per persons in smokers with
normal lung function)103. This study has also shown that the most frequent type of lung cancer was
squamous cell carcinoma (44%) and lung cancer incidence was lower in patients with worse severity of
airflow obstruction. GOLD stages I and II, older age, lower body mass index, and lung diffusion capacity
of carbon monoxide less than 80 per cent were associated with lung cancer diagnosis103.

Depressive symptoms were found to be common among patients with COPD104. In a study consisting of
2,118 subjects with COPD, 335 smokers without COPD (smokers), and 243 non-smokers without COPD
(non-smokers), 26, 12, and 7 per cent of COPD, smokers, and non-smokers, respectively have been
found to suffer from depression. In subjects with COPD, higher depression prevalence was seen in
females, current smokers, and those with GOLD-defined severe disease105. Frontal-type cognitive decline
with the worsening of the hypoxemia has been reported in COPD106.

Anaemia was observed in 17 per cent of patients with COPD compared to 6 per cent seen with
polycythemia and anaemia was an independent risk factor for reduced functional capacity in COPD107.

Exacerbations

Exacerbation in COPD is defined as an acute event characterised by a worsening of the patient's

respiratory symptoms that is beyond normal day-to-day variations and leads to a change in medication7.
COPD exacerbations are important because they are associated with significant morbidity, health care
cost and mortality108. Several factors exacerbate COPD and the common factors are bacterial or viral
respiratory tract infections. Air pollution is another contributing factor. The cause of exacerbations
cannot be identified in one-third of cases. Patients with 2 or more exacerbations per year are classified
as “frequent exacerbators”. A new patient-reported outcome diary known as EXAcerbation of Chronic
Pulmonary Disease Tool (EXACT) has been developed to evaluate the frequency, severity, and duration
of exacerbations of COPD and this 14-item daily diary has been found to be reliable, valid, and sensitive
to changes during recovery from exacerbation109. Bafadhel et al110 using unbiased analysis have
identified four distinct biologic exacerbation clusters and these were bacterial, viral, eosinophilic and
pauci inflammatory. They have also found that sputum IL-1β, serum CXCL10, and peripheral eosinophils
are biomarkers of bacteria-, virus-, or eosinophil associated exacerbations of COPD110. Tanabe et al111
reported that annual changes in CT parameters of emphysema are greater in patients with a history of
exacerbations of COPD than in those without a history of exacerbations suggesting that exacerbations
accelerate emphysema progression in patients with COPD111. A systematic review of the literature to
determine the prevalence of pulmonary embolism in acute exacerbations of COPD had revealed that
one of four COPD patients who require hospitalization for an acute exacerbation might have pulmonary
embolism112.

The diagnosis of exacerbation is based on the acute change of symptoms (baseline dyspnoea, cough
and/or sputum production) that is beyond normal day-to-day variation. Differential diagnosis of COPD
exacerbations includes pneumonia, pulmonary embolism, congestive cardiac failure, cardiac
arrhythmias, pneumothorax and pleural effusion. These conditions may mimic and/or aggravate
exacerbations and have to be treated if identified. The assessment of severity of exacerbations can be
assessed by pulse oxymetry (for adjusting supplemental oxygen therapy), arterial blood gases (for
diagnosis of acute-on-chronic respiratory failure), acid-base status (for initiating mechanical ventilation),
chest X-rays to exclude alternate causes, electrocardiogram to diagnose cardiac conditions and whole
blood count to identify polycythemia, anaemia or leucocytosis. In addition, the presence of purulent
sputum is an indication for initiating empiric antibiotic treatment. Common pathogens in an
exacerbation are Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis.
Pseudomonas aerugenosa can be identified in COPD patients belonging to the GOLD groups 3 and 4.
Electrolyte abnormalities and hyperglycaemia may be due to the associated co-morbidities87.

Management

(i) Pharmacological agents

The drugs for treatment of COPD are inhaled bronchodilators, inhaled corticosteroids, oral theophylline
and oral phosphodiesterase-4 inhibitor. Oxygen therapy is indicated in COPD patients with chronic
respiratory failure with hypoxemia.

(a) Bronchodilators: Inhaled bronchodilators are the main pharmacological agents that improve
symptoms, decrease exacerbations and improve quality of life in COPD113. Bronchodilators can cause
only a small (<10%) increase in FEV1 in patients with COPD. Though there is only a small improvement in
spirometric measurements, bronchodilators may improve symptoms especially dyspnoea by reducing
hyperinflation114,115. Inhaled bronchodilators can be either β2-adrenergic receptor agonists or cholinergic
receptor antagonists. β2-adrenergic receptor agonists can be short-acting (e.g. salbutamol) or long-
acting (e.g. formoterol fumarate and salmeterol xinafoate). Similarly, cholinergic receptor antagonists
can be short-acting (e.g. ipratropium bromide) or long-acting (e.g. tiotropium bromide). The duration of
action of inhaled short-acting β2-agonists is 4 to 6 h and that of short-acting inhaled anticholinergics
lasts up to 8 h. The duration of action of inhaled long-acting β2-agonists is 12 h or more and the action of
inhaled long-acting anticholinergics lasts more than 24 h. The adverse effects of inhaled short-acting β2-
agonists include sinus tachycardia, somatic tremor and hypokalemia. The important adverse effects of
inhaled anticholinergics are dry mouth and occasional prostatic symptoms.
Patients with mild airflow limitation can be treated with a single short-acting inhaled bronchodilator,
either with salbutamol or with ipratropium. Both drugs are equally effective to relieve symptoms and to
improve airflow. Patients with moderate airflow limitation require treatment with either a long-acting
β2-adrenergic receptor agonist (formoterol or salmeterol) or long-acting cholinergic receptor antagonist
(tiotropium). A short-acting bronchodilator (not a long-acting inhaled bronchodilator) is the appropriate
treatment for relief of acute symptoms. Combination of short-acting bronchodilators, a β2-adrenergic
receptor agonist and a cholinergic receptor antagonist (e.g. salbutamol and ipratropium) has been
shown to have a greater bronchodilation than either drug used alone116. Combining a long-acting β2-
adrenergic receptor agonist (e.g. salmeterol) with a short-acting cholinergic receptor antagonist (e.g.
ipratropium) has been shown to improve airways obstruction117. In a randomized, double-blind trial in
patients with COPD, the Understanding Potential Long-Term Impacts on Function with Tiotropium
(UPLIFT) study has demonstrated that treatment with tiotropium was associated with improvements in
lung function, quality of life, and exacerbations during a 4-year period but did not significantly reduce
the rate of decline in FEV1118. In a 1-year, randomized, double-blind, double-dummy, parallel-group trial,
the investigators of the Prevention of Exacerbations with Tiotropium in COPD (POET-COPD) trial
reported that tiotropium (18 μg once daily) is more effective than salmeterol (50 μg twice daily) in
preventing exacerbations in patients with moderate-to-very-severe COPD119.

Glycopyrronium is a novel long-acting anticholinergic and is a synthetic quaternary ammonium

compound acting as a competitive antagonist by binding to muscarinic receptors in bronchial smooth
muscle. It is currently in development for the treatment of COPD. The effect of glycopyrronium (50 μg) is
similar to that of tiotropium in reducing dyspnoea and the risk of exacerbations, as well as improving
lung function, exercise tolerance, and health status in patients with COPD120,121.

Indacaterol is an “ultra” long-acting β2-adrenergic agonist that is distinguished by once-daily dosing. The
duration of action of inhaled indacaterol is >24 h compared to twice-daily dosing of other long-acting β2-
adrenergic agonists such as salmeterol and formoterol that have a bronchodilator action of about 12 h.
Indacaterol has a fast onset and produces sustained bronchodilation. It relaxes bronchial smooth
muscles to reduce the symptoms of COPD and is well tolerated. Indacaterol is intended for the long-
term maintenance treatment of COPD122. Indacaterol (150 or 300 μg) was found to be an effective once-
daily bronchodilator and was at least as effective as tiotropium in improving clinical outcomes for
patients with COPD122. Indacaterol 150 μg administered once daily had been shown to have a clinically
relevant bronchodilator effect over 24 h post-dose and improved health status and dyspnoea to a
greater extent than twice-daily 50 μg salmeterol123. Indacaterol given to COPD patients for one year was
well tolerated and provided significant and well-maintained bronchodilation that was accompanied by
improved clinical outcomes124. Feldman et al125 had shown that low dose (75 μg) of indacaterol can be
used for maintenance therapy for patients with COPD and indacaterol at this dose showed positive
benefit in both decreasing dyspnoea and improving quality of life. The US FDA has approved 75 μg once-
daily dose of indacaterol for use as a long-term maintenance treatment for patients with COPD126.

(b) Corticosteroids: The fact that COPD is associated with chronic inflammation is the rational for the use
of inhaled corticosteroids in COPD. There is no evidence that inhaled or oral steroids suppress
inflammation in COPD127. This is in contrast to the beneficial effects of inhaled steroids in the treatment
of chronic asthma. However, there are evidences that inhaled and systemic steroids have beneficial
effects in acute exacerbations of COPD128,129. Inhaled steroids have been shown to improve symptoms,
lung function, quality of life and to reduce the frequency of exacerbations in COPD patients with FEV1
<50 per cent predicted130–132. Adverse effects of inhaled corticosteroids are oral candidiasis, hoarseness
of voice and skin bruising. Long-term treatment with inhaled corticosteroids has been shown to be
associated with an increased risk of pneumonia130,133,134. Oral corticosteroids are not recommended as
long-term monotherapy in COPD patients and have numerous side effects if administered long-term.

(c) Phosphodiesterase inhibitors: Theophylline, a weak oral bronchodilator is a non-selective

phosphodiesterase inhibitor and has some anti-inflammatory properties. However, its narrow
therapeutic index is a concern requiring frequent monitoring of blood levels, adverse drug reactions and
drug interactions. COPD patients, if continued to be symptomatic despite combined inhaled
bronchodilator treatment, can be prescribed theophylline and it provides additional improvement in
lung function with a few exacerbations135. Important adverse effects of theophylline are atrial and
ventricular arrhythmias, convulsions, headache, insomnia and nausea. Theophylline has also interactions
with many commonly used medications.

Roflumilast is a phosphodiesterase-4 (PDE-4)inhibitor and it reduces inflammation by inhibiting the

breaking down of intracellular cyclic AMP. It is administered orally with a once a day schedule (500 mg)
and it reduces acute exacerbations in patients with COPD136. Roflumilast used concomitantly with long-
acting β2 agonists has been shown to reduce exacerbations in COPD137,138. Adverse reactions with
roflumilast include nausea, diarrhoea, sleep disturbances, headache, and weight loss.

(ii) Pharmacotherapy

The clinical diagnosis of COPD is based on the history of progressive and persistent dyspnoea that
worsens with exercise, chronic cough which may be initially intermittent and may be unproductive,
chronic sputum production of any pattern, history of exposure to risk factors (tobacco smoke, smoke
from home cooking and heating fuels, occupational dusts and chemicals) and a family history of COPD7.
Spirometry is required to confirm the presence of persistent airflow limitation which is defined as the
presence of post-bronchodilator FEV1/FVC <70.

(a) Assessment of disease: The assessment of COPD is required to determine the severity of the disease,
its impact on the health status and the risk of future events (e.g. exacerbations, hospital admissions or
death) and this is essential to guide therapy. Assessment of COPD is achieved by considering the
patient's current symptoms, the severity of spirometric abnormality, the exacerbation risk and the
presence of comorbidities separately. GOLD guidelines recommend Modified British Medical Council
(mMRC) questionnaire or COPD Assessment Test (CAT) to assess symptoms139,140. Spirometric
assessment is required to classify the severity of airflow limitation. Spirometric evaluation is to be done
after administration of inhaled short-acting bronchodilator. The best predictor of having frequent
exacerbations (2 or more exacerbations per year) is a history of previous treated events141 and
worsening airflow limitation is also associated with an increasing prevalence of exacerbations and risk of
death7. Assessment of comorbidities is essential in COPD, as these can influence mortality and
hospitalizations in COPD85.

Combined COPD assessment is based on the combination of the symptomatic assessment with the
spirometric classification and/or risk of exacerbations. The assessment of symptoms based on mMRC
questionnaire or CAT scale indicates the level of symptoms. A high level of symptom is indicated when
the mMRC grade is >2 or the CAT score is >10. Only one scale either mMRC grade or CAT scale is
sufficient to assess the symptoms, preferring the CAT scale. Exacerbation risk can be assessed by using
GOLD spirometric classification and by the individual patient's history of exacerbations. GOLD
spirometric categories 3 or 4 and two or more exacerbations in the preceding year indicate high risk. If
the risk assessment done based on spirometric categories or exacerbation history shows any
discrepancy, the assessment that provides the highest risk is to be used. Combined COPD assessment
done as mentioned provides four groups as follows7:

Group A (Low risk, less symptoms): GOLD 1 or 2 (mild or moderate airflow limitation) and/or 0-1
exacerbation per year and mMRC grade 0-1 or CAT score <10.

Group B (Low risk, more symptoms): GOLD 1 or 2 (mild or moderate airflow limitation) and/or 0-1
exacerbation per year and mMRC grade >2 or CAT score >10.

Group C (High risk, less symptoms): GOLD 3 or 4 (severe or very severe airflow limitation) and/or >2
exacerbation per year and mMRC grade 0-1 or CAT score <10.

Group D (High risk, more symptoms): GOLD 3 or 4 (severe or very severe airflow limitation) and/or >2
exacerbation per year and mMRC grade >2 or CAT score >10.

Group A patients are treated with a short-acting bronchodilator (either short-acting anticholinergic or
short-acting β2-agonist) as the first choice. The second choice is a combination of short-acting
bronchodilators (short-acting anticholinergic and short-acting β2-agonist) or a long-acting bronchodilator
(either long-acting anticholinergic or long-acting β2-agonist). Theophylline is an alternative choice.

Group B patients can be treated with a long-acting bronchodilator (either long-acting anticholinergic or
long-acting β2-agonist). Patients with severe breathlessness in group B can be treated with a
combination of long-acting anticholinergic and long-acting β2-agonist. Alternate choice is short-acting
bronchodilators (short-acting anticholinergic and/or short-acting β2-agonist) and theophylline.

Group C patients require treatment with a fixed combination of inhaled corticosteroids and long-acting
β2-agonist or long-acting anticholinergic. The second choice of treatment is with a combination of long-
acting anticholinergic and long-acting β2-agonist. Alternate treatment is with short-acting
bronchodilators (short-acting anticholinergic and/or short-acting β2-agonist) and theophylline. A
phosphodiesterase-4 inhibitor can also be added.

Group D patients can be treated with a fixed combination of inhaled corticosteroids and long-acting β2-
agonist or long-acting anticholinergic. Different drug combinations are recommended as second choice
for treatment of group D patients. The combinations are inhaled corticosteroid and long-acting
anticholinergic or inhaled corticosteroid + long-acting β2-agonist and long-acting anticholinergic or
inhaled corticosteroid + long-acting β2-agonist and phosphodiesterase-4 inhibitor or long-acting β2-
agonist and long-acting anticholinergic or long-acting anticholinergic and phosphodiesterase-4 inhibitor.
Alternate treatment is with short-acting bronchodilators (short-acting anticholinergic and/or short-
acting β2-agonist) and theophylline and carbocysteine.

(b) Oxygen therapy: Patients with COPD with respiratory failure and with severe resting hypoxemia on
long-term oxygen therapy (LTOT) (>15 h per day) have been found to have increased survival. LTOT is
prescribed to COPD patients with PaO2 <7.3 kPa (55 mm Hg) or SaO2 <88 per cent with or without
hypercapnia confirmed twice over a three week period or PaO2 between 7.3 kPa (55 mm Hg) and 8 kPa
(60 mm Hg) with evidence of pulmonary hypertension, peripheral oedema indicating congestive cardiac
failure or polycythemia (haematocrit >55)142,143.

(c) Exacerbations: The treatment of exacerbations in COPD is with bronchodilators, corticosteroids and
antibiotics. Short-acting inhaled β2-agonists or short-acting anticholinergics are the preferred
bronchodilator for the treatment of exacerbations144. Short-acting bronchodilators can be given either
by metered-dose inhalers or by nebulizers and there are no differences in FEV1 whether given by
metered-dose inhalers or by nebulizers145. When there is insufficient response to inhaled short-acting
bronchodilators, intravenous methylxanthines (theophylline or aminophylline) can be given, keeping in
mind the adverse effects and drug interactions of methylxanthines146,147. Systemic corticosteroids have
been found to shorten recovery time and arterial hypoxemia129,148. The systemic corticosteroids also
reduce the risk of early relapse, treatment failure and length of hospital stay148,149. Oral prednisolone 30-
40 mg daily is given for 10-14 days. Alternative treatment is with nebulized budesonide. Increase in
dyspnoea, sputum volume and sputum purulence are the cardinal features of exacerbations in COPD.
Antibiotics for 5 to 10 days are prescribed if two of the three cardinal symptoms (increased purulence of
symptoms is one of the symptoms) are observed. The COPD Clinical Research Network undertook a
study to determine whether azithromycin decreased the frequency of exacerbations in patients with
COPD, as macrolide antibiotics have immunomodulatory, anti-inflammatory, and antibacterial effects150.
COPD patients (n=1142) with a history of prior exacerbation were randomised to receive azithromycin
250 mg daily or a placebo and continued their usual care. The study showed that azithromycin 250 mg
daily taken daily for 1 year, when added to usual treatment in COPD patients, decreased the frequency
of exacerbations and improved quality of life. However, azithromycin caused hearing decrements in a
small percentage of subjects151. Supplemental oxygen is required to maintain arterial oxygen saturation
88 to 92 per cent. Ventilatory support either non-invasive mechanical ventilation or mechanical
ventilation based on proper indications is required in patients in COPD patients with severe
exacerbations admitted to hospitals.

(iii) Non-pharmacologic treatment

(a) Smoking cessation: Smoking cessation is the most important step in the treatment of COPD. Smoking
cessation has been found to reduce the decline of FEV1152. Nicotine replacement treatment with
nicotine gum, inhaler, nasal spray, transdermal patch, sublingual tablet or lozenges has been found to
increase long term smoking-abstinence rates. Varenicline and bupropion are pharmacologic agents for
the treatment of tobacco addiction. Smoking cessation counselling is also effective to treat tobacco
addiction. It has been reported that even a 3 min counselling to a smoker enables smoking cessation
rates of 5 to 10 per cent153. Patients with COPD who smoke and receive intensive counselling or a
combination of intensive counselling and nicotine replacement therapy (NRT) or bupropion had
significantly higher abstinence rates154.

(b) Pulmonary rehabilitation: Pulmonary rehabilitation is an important component of therapy of COPD.

The components of a comprehensive pulmonary rehabilitation programme include exercise training,
smoking cessation, nutrition counselling and education. The benefits of pulmonary rehabilitation include
improvement in exercise capacity, reduction in the perceived intensity of breathlessness, improvement
in health-related quality of life, reduction in the number of hospitalizations and days in the hospital and
reduction in anxiety and depression associated with COPD. In an evidence-based review of the literature
surrounding treatment strategies for patients with COPD, pulmonary rehabilitation including at least 4
wk of exercise training is shown to cause clinically and statistically significant improvements in health
related quality of life (HRQOL) in patients with COPD and pulmonary rehabilitation also leads to a
clinically and statistically significant improvement in functional exercise capacity155. In a randomized,
double-blind, placebo-controlled trial (tiotropium, n=47; placebo, n=44), tiotropium (18 μg)
administered to COPD patients participating in 8 wk of pulmonary rehabilitation (treadmill training three
times a week; ≥30 min per session), it has been demonstrated that tiotropium in combination with
pulmonary rehabilitation produced clinically meaningful improvements in dyspnoea and health status
compared to pulmonary rehabilitation alone. Improvements with tiotropium were sustained for 3
months following pulmonary rehabilitation completion156.

(c) Nutritional support: Patients from the Copenhagen City Heart Study involving 1,218 men and 914
women, aged 21 to 89 yr, with airway obstruction defined as an FEV1/FVC ratio < 0.7 were prospectively
examined to know whether body mass index (BMI) is an independent predictor of mortality in subjects
with COPD. This study has shown that low BMI is an independent risk factor for mortality in subjects
with COPD, and that the association is strongest in subjects with severe COPD157. In a prospective cohort
study from Korea, it has been observed that the risk of death from respiratory causes was higher among
subjects with a lower BMI158. Survival analysis studies have shown that body weight has an independent
effect on survival in COPD and the negative effect of low body weight can be reversed by appropriate
therapy in some of the patients with COPD90. Chailleux et al159 had shown that nutritional depletion was
an independent risk factor for mortality and hospitalization in patients with COPD receiving LTOT and
the best prognosis was observed in overweight and obese patients. European Society for Parenteral and
Enteral Nutrition (ESPN)) guidelines state that enteral nutrition (EN) in combination with exercise and
anabolic pharmacotherapy has the potential to improve nutritional status and function in COPD patients
and frequent small amounts of oral nutritional supplements are preferred in order to avoid postprandial
dyspnoea and satiety as well as to improve compliance160. It has been reported that nutritional
supplementation may have a role in the management of COPD when provided as part of an integrated
rehabilitation programme incorporating a structured exercise component as an anabolic stimulus161.
Ghrelin is a novel growth hormone (GH)-releasing peptide that also induces a positive energy balance by
decreasing fat utility and stimulating feeding through GH-independent mechanisms. Plasma ghrelin level
has been shown to be decreased in COPD and this is different from other weight-loss diseases162.
Repeated administration of ghrelin has been found to improve body composition, muscle wasting,
functional capacity, and sympathetic augmentation in cachectic patients with COPD163.

(iv) Surgical treatment

(a) Lung volume reduction surgery: The National Emphysema Treatment Trial is a randomized,
multicenter clinical trial that compared lung-volume-reduction surgery (LVRS) with medical treatment.
Patients with emphysema who have a low FEV1 and either homogeneous emphysema or a very low
carbon monoxide diffusing capacity are at high risk for death after surgery and also are unlikely to
benefit from the surgery164. LVRS has been shown to improve mortality, exercise capacity, and QOL in
selected patients with upper lobe emphysema and poor exercise capacity. Patients with non-upper lobe
emphysema and high baseline exercise capacity are poor candidates for lung-volume-reduction surgery,
because of increased mortality and negligible functional gain165. Bilateral LVRS procedures result in
greater short-term improvement than unilateral LVRS. Improvement has also been reported in dyspnoea
and health status after LVRS and this is better preserved over longer-term follow up than physiological
improvement. It has also been observed that physiological benefits are similar with video-assisted
thoracoscopy (VATS) or median sternotomy (MS) techniques166. It has been reported that LVRS produces
superior patient outcomes compared to medical treatment in terms of exercise capacity, lung function,
quality of life and long-term (>1 yr post-operative) survival especially for patients with upper-lobe-
predominant disease and low exercise capacity, but with a much greater cost per person over five
years167,168.

Alternative methods of lung volume reduction include bronchoscopic lung volume reduction and
endobronchial valve placement. Endobronchial valve placement has been shown to improve lung
volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolongs exercise
time by reducing dynamic hyperinflation169. Shah et al170 studied lung volume reduction by placing
paclitaxel-coated metal stents through bronchoscope into the emphysematous lung in a randomised
trial. This method creates a bypass allowing exhalation from hyperinflated lung regions. Though there
were significant improvements in radiographic lung volume, symptoms and lung physiology on day one,
the beneficial effects were not sustained and the airway bypass intervention failed to improve dyspnoea
and pulmonary function at 6 months170.

(b) Lung transplantation: Lung transplantation is an option in COPD patients who have FEV1 below 25
per cent predicted and/or the paCO2 is > or = 55 mm Hg. Both single- and double-lung transplant have
been reported in COPD. The reported survival rates after lung transplantation are approximately 80 per
cent 1-year, 50 per cent 5-year, and 35 per cent 10-year. The most important long-term complication
after lung transplantation is bronchiolitis obliterans resulting in decreased pulmonary function166.
Despite significant progress over the past 25 years, both short- and long-term outcomes remain
significantly inferior for lung recipients relative to other “solid” organs171.

(v) Immunization
Vaccinations can prevent some of the infections that cause COPD exacerbations and can be
administered to patients with COPD172. Influenza vaccination reduces lower respiratory tract infections
and death in patients with COPD173,174. In a study of 177,120 patients with COPD (mean age 65 yr) with a
mean follow up of 6.8 yr between 1988 and 2006, it had been observed that influenza but not
pneumococcal vaccination was associated with a reduced risk of all-cause mortality in COPD175. Two
types of pneumococcal vaccines, polysaccharide and polysaccharide conjugated vaccines, are available.
Studies have shown conflicting results with regard to the effectiveness and efficacy of the 23-valent
polysaccharide vaccine. Pneumococcal polysaccharide vaccine is useful in COPD patients 65 yr and older
and in younger patients with significant comorbid conditions such as cardiac disease176,177. However,
conjugate vaccine is found to have superior immunogenicity178. The pneumococcal polysaccharide
conjugate vaccine (PCV) comprises capsular Streptococcus pneumoniae polysaccharide serotypes that
are individually conjugated to non-toxic diphtheria protein. Immunization with conjugated vaccines
results in the development of T cell dependent immune responses, whereas unconjugated vaccines do
not lead to booster responses on revaccination179. GOLD guidelines recommend influenza and
pneumococcal vaccinations to COPD patient and state that these are more effective in older patients
and those with severe disease or cardiac morbidity7.

X. Conclusions and future directions

The Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults
funded by the Indian Council of Medical Research had shown that the overall prevalence of chronic
bronchitis in adults > 35 years is 3.49% (21) and this study shows that COPD is an important public
health problem in India. As there are differences in clinical presentation and in the progression of
disease in COPD, there is a need to understand different phenotypes in relation to clinical presentation,
changes in pulmonary function, exacerbations, response to treatment and prognosis. It is increasingly
realised that COPD may be due to non-smoking factors especially in our country where solid fuels are
used as a source for domestic energy. The indoor biomass smoke from these sources may be an
important factor causing COPD. There is a need to study the differences, if any, in pathogenesis of
smoking-induced COPD and non-smoking induced COPD. The contribution of bidi smoking in causing and
aggravating COPD compared to cigarette smoking is another area for future research. It has already
been known that alpha-1 antitrypsin deficiency predisposes to development of COPD. Future studies
including genome-wide linkage studies and other related studies may establish specific genes that
contribute to the development of COPD. There is a growing realisation that COPD is a disease not
confined to the lung alone, but is being recognised as systemic disease with multi-system
manifestations. Better understanding of the pathogenesis in future may throw light on the
consequences of COPD on other organs and new therapeutic options may emerge from the on-going
studies. Globally, COPD will be the third leading cause of death by 2030180, though COPD is a
preventable disease. Therefore, urgent action is required from medical community and policy makers to
reduce the burden of disease in our country by adopting appropriate preventive strategies giving due
attention to COPD as is being done to diseases such as heart diseases and diabetes mellitus.

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