The Management of Psychiatric Emergencies: Medicine
The Management of Psychiatric Emergencies: Medicine
The Management of Psychiatric Emergencies: Medicine
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FIGURE 1
The differential diagnosis and acute treatment of psychomotor excitement and agitation
AP, antipsychotic drugs; BDZ, benzodiazepines
the Social Psychiatry Service—can petition the respon- non-emergency psychiatric or medical interview, both
sible court to commit a person with a mental disturbance because of the intensity of the patient’s disease state and
to a psychiatric hospital because of an acute danger to this because of the possible danger to the patient or others (9).
person or other persons, in order to avert harm. In some Along with noting the patient’s main subjective com-
circumstances, help can be officially requested and ob- plaints, the examiner must observe the patient’s behavior
tained from the police and/or the fire department, if closely while examining him or her, paying attention to
necessary (Box 1). spontaneous movements and any signs of psychomotor
In an emergency situation, the physician must establish agitation, tension, or impulsiveness. If persons other than
conversational contact with the patient and take the history the patient can supply any further history, the examiner
more rapidly and in more structured fashion than in a should ask them specifically about the patient’s behavior
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FIGURE 2 BOX 4
an anxious quality or as more severe conditions ranging are taken to protect them from harming themselves or
to a highly excited state with marked aggressiveness. behaving aggressively toward others.
The following organic conditions can cause an excited
state: Therapeutic measures
● dementing diseases The main objective in treating acute states of excitation
● medical illnesses such as hyperthyroidism or and agitation is to keep the patient from inflicting harm
myocardial infarction on him- or herself and others. This is generally accom-
● neurological disturbances such as encephalitis, sub- plished with pharmacotherapy (most often by sedation),
arachnoid hemorrhage, or postictal state. which must not, however, be allowed to stand in the way
Excited states in the setting of dementing diseases are of a further differential-diagnostic evaluation (13).
usually associated with spatial and temporal disorien- “Talking down” is often successful: this is the attempt to
tation, and commonly also with abnormal behavior. The calm the patient verbally by speaking with him or her in
possibility of an underlying medical illness should be a friendly way, in an even tone, and maintaining conver-
ruled out (or confirmed) by a thorough diagnostic evalu- sational contact (1). An excited state may wear off over
ation of the potential organic causes. Acute neurological a short period of time only to come back rapidly and be-
disturbances of brain function usually impair conscious- come even more severe than before (“the calm before
ness; in some cases, such disturbances are hard to tell apart the storm”), giving a misleading picture of the actual
from intoxication with a psychotropic substance. Patients danger. One should, therfore, always try to have trained
in an impulsive and hostile excited state need, above all, to nurses or other auxiliary staff in the room during the in-
be monitored in an intensive care setting while measures itial contact with an aggressive, tense patient. Dealing
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with the patient too energetically may only increase his dose, leading to yet more akathisia. The first-line treat-
or her aggressiveness, and one should beware of overes- ment of acute akathisia is with anticholinergic drugs,
timating oneself, as patients in excited states can muster benzodiazepines, amitriptyline, or the beta-blocker pro-
great strength. In such cases, the examiner’s first duty is pranolol. Moreover, the antipsychotic drug that induced
to see to his or her own safety. akathisia should be changed, or its dose lowered.
Excited states with an anxious coloration in patients
taking stimulants and hallucinogenic drugs are best Self-destructive and suicidal behavior
treated with benzodiazepines (14) (Figure 1). In agi- Diagnostic evaluation
tation due to withdrawal of alcohol, opioids, or sleeping Suicidality and self-destructive behavior account for
medication, clomethiazol p.o. is the medication of first up to 15% of psychiatric emergencies (3, 15, 17). In
choice to prevent delirium, or to treat delirium that is this connection, the physician may face the very diffi-
already present; clonidine or a beta-blocker can be added cult task of gauging the risk of suicide in a patient who
to treat any accompanying autonomic manifestations, has already attempted suicide or who currently has
while an antipsychotic can be added to treat psychosis. suicidal ideation. The phases classically described by
Another way to treat alcohol withdrawal syndrome, Pöldinger (18) and the pre-suicidal syndrome de-
particularly when it presents with seizures, is with a ben- scribed by Ringel (19) are not always floridly present
zodiazepine, such as diazepam or lorazepam. Opioid (17). In general, the suicide rate rises with advancing
withdrawal syndrome is treated instead with a sedating age (20). Further factors associated with an elevated
antidepressant, such as doxepin. When taking patients risk of suicide include the following:
off benzodiazepines, one should take care not to lower ● prior suicide attempts
the dose too quickly. Psychomotor excitement with ● alcohol and drug dependency
aggressive behavior as a component of schizophrenic ● the loss of important persons in the patient’s life
psychosis, a problem often necessitating police interven- ● long depressive episodes
tion(15), can be treated effectively with antipsychotic ● prior psychiatric treatment
drugs (16) (Box 2). ● physical illness
Psychomotor excitement and agitation are also typical ● unemployment or retirement
features of agitated depression, although, in this condi- ● rejection of offers of help
tion, the depressive mood is usually obvious, pointing the ● a history of violent behavior.
way to the correct diagnosis. In agitated depression, as in About 98% of persons who commit suicide are
other types of depression, antidepressants take effect only either mentally or physically ill. Elderly men living
after a delay; thus, a benzodiazepine or low-potency anti- alone are more likely to commit suicide than elderly
psychotic drug should be added on at once, to provide im- women living alone. Living in a city, rather than the
mediate relief. Excited states caused by panic attacks are country, is a further risk. Suicide is also more common
best treated with benzodiazepines, if pharmacotherapy is in the spring and summer than in the autumn and
the treatment chosen. States of excitement and agitation winter. Many suicide attempts are never detected as
can be seen in acute stress reactions, too, or as a manifes- such: in Germany, where about 12 500 people commit
tation of diseases from the anxiety disorder spectrum; suicide every year, the number of suicide attempts is es-
benzodiazepines are indicated in such cases as well, but timated to be between 5 and 30 times higher than this.
they should be replaced as soon as possible with targeted 80% of persons who commit suicide have previously
psychotherapy because of the potential for abuse. stated their intention to do so—often, for example, to
It should not be forgotten that a state of agitation can their family physician, through a remark such as “I
also be caused by antipsychotic or other dopaminergic can’t see any meaning to it all any more,” or the like.
medication, e.g., by metoclopramide. This type of agi- 30% to 40 % of suicide victims attempted suicide at
tation, called akathisia, is characterized by restless least once beforehand (9, 17) (Box 3).
movements of (mainly) the legs when the patient either It is often difficult to decide whether inpatient treat-
sits or stands, often accompanied by a distressing feel- ment is needed or outpatient treatment suffices.
ing of unrest. If akathisia is misinterpreted as a Reasons for hospital admission include
psychotic manifestation, a vicious circle can arise in ● a lack of social connections,
which akathisia leads to an increase in the antipsychotic ● a history of impulsive behavior,
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● concrete plans for a suicidal act, or parasuicidal medical supervision for a period of up to several days.
behavior. Self-destructive behavior in intellectually impaired
In an emergency situation, it is often hard to tell at persons generally takes the form of jactations (rhyth-
first whether the apparent suicide attempt was more a mic back-and-forth movements of the body), or of
cry for help or an actual aggressive act against the self biting of the lips, hands, and arms; on the other hand,
with the serious intention of committing suicide. persons who are emotionally unstable or who have an
emotionally unstable personality disorder of border-
Therapeutic measures line type or an impulse-control disorder often present
In every case of self-destructive behavior or attempted with recurrent self-inflicted cutting injuries. Most of
suicide, emergency management should include the these patients have a decreased sensitivity to pain.
provision of immediate medical care (diagnosis and Repetitive self-injury in such cases is usually due to
treatment of the underlying psychiatric disturbance), conflicts with the patient’s social environment;
the elucidation of existing acute conflicts, and an at- because of a low tolerance for frustration, the patient
tempt to establish a therapeutic bond that the patient responds to these conflicts with severely hurt feelings
experiences as helpful and durable, through the use of or the desire to lower inner tension. It is especially
concrete agreements. The patient should be told about difficult for the physician to establish robust contact
the possibility of, and perhaps the need for, an exam- with such patients in the setting of a psychiatric
ination by a psychiatrist, and should be prepared for emergency, just as it is with suicidal patients in gen-
this examination. Particular caution is needed if the eral; serious mistakes can be made (21) (Box 4).
patient is uncooperative, refuses to accept help, triv- All suicidal patients and all patients who have at-
ializes the danger of the suicide attempt, or manifests tempted suicide should undergo psychotherapy and
an abrupt change to a highly relaxed or even euphoric rehabilitation, either individually or in group therapy
mood. If suicidality persists, and no reliable agree- (22).
ment with the patient can be reached, then the patient
must be admitted to a protected psychiatric ward for Conflict of interest statement
close observation and surveillance. Thus, in some The authors declare that no conflict of interest exists.
cases, involuntary commitment in accordance with
Manuscript submitted on 1 February 2010; revised version accepted on
the law cannot be avoided. Self-destructive behavior 10 August 2010.
(which may be repetitive) is not the same thing as sui-
cidal or parasuicidal behavior; it is seen, for example, Translated from the original German by Ethan Taub, M.D.
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7. Simpson AE, Emmerson WB, Frost AD, Powell JL: “GP Psych 16. Thomas P, Alptekin K, Gheorghe M, Mauri M, Olivares JM, Riedel M:
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1–20. 19. Ringel E: Der Selbstmord. Abschluß einer krankhaften psychischen
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Please answer the following questions to participate in our certified Continuing Medical Education
program. Only one answer is possible per question. Please select the answer that is most appropriate.
Question 4 Question 9
Which of the following medications is least suitable for the treat- Which of the following is a sedating antidepressant used to treat
ment of an excited, agitated patient? opioid withdrawal syndrome in the psychiatric emergency set-
a) diazepam ting?
b) zuclopenthixol a) alfentanil
c) haloperidol b) pipamperone
d) sertraline c) valproic acid
e) levomepromazine d) lithium
e) doxepin
Question 5
What is the therapeutic goal of “talking down”? Question 10
a) to calm the patient verbally Which of the following are rare presentations of psychiatric
b) to relax the patient with meditation exercises emergencies?
c) to discuss the patient’s state of tension with the patient a) visual hallucinations, illusory misidentifications, suggestibility, and
d) to calm the patient through physical contact fidgeting
e) to converse quietly with the patient b) cognitive disturbances and intermittent disorientation
c) dermatozoal delusion and obsessive-compulsive manifestations
Question 6 d) psychomotor excitation and agitation or self-destructive or suicidal
Which of the following is associated with an increased risk of behavior
attempting suicide? e) depression
a) a steady job
b) brief episodes of melancholy
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