Essentials of Community Medicine

Contents i
Essentials of Community Medicine

A Practical Approach
Essentials of Community Medicine
A Practical Approach
SECOND EDITION
Lalita D Hiremath MD
Professor
Department of Community Medicine
S Nijalingappa Medical College
Bagalkot, Karnataka, India
Dhananjaya A Hiremath MD
Professor
Department of Anesthesia
Foreword
SJ Nagalotimath
JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD

New Delhi Panama City London

Jaypee Brothers Medical Publishers (P) Ltd
Headquarter
Jaypee Brothers Medical Publishers (P) Ltd
4838/24, Ansari Road, Daryaganj
New Delhi 110 002, India
Phone: +91-11-43574357
Fax: +91-11-43574314
Email: [email protected]
Overseas Offices
JP Medical Ltd Jaypee-Highlights Medical Publishers Inc.
83 Victoria Street London City of Knowledge, Bld 237, Clayton
SW1H 0HW (UK) Panama City, Panama
Phone: +44-2031708910 Phone: 507-301-0496
Fax: +02-03-0086180 Fax: +507-301-0499
Email: [email protected] Email: [email protected]
Website: www.jaypeebrothers.com
Website: www.jaypeedigital.com
2012, Jaypee Brothers Medical Publishers
All rights reserved. No part of this book may be reproduced in any form or by any means
without the prior permission of the publisher.
Inquiries for bulk sales may be solicited at: [email protected]
This book has been published in good faith that the contents provided by the authors contained
herein are original, and is intended for educational purposes only. While every effort is made to
ensure accuracy of information, the publisher and the authors specifically disclaim any damage,
liability, or loss incurred, directly or indirectly, from the use or application of any of the contents of
this work. If not specifically stated, all figures and tables are courtesy of the authors.
Essentials of Community MedicineA Practical Approach
First Edition: 2004

Reprint: 2006
Second Edition: 2012
ISBN: 978-93-5025-044-0
Printed at
Foreword
There was a time when medical students used to consider community medicine
as a less important subject. The result sheet used to show passing percentage
over 95 percent. But the subject has gained importance steadily. Today it is
one of the important subjects. Not only the theory but the practicals are also
important.
Students need a manual to complete the practicals. However, a useful
practical manual was not available. This lacunae is being fulfilled herewith
by Dr Dhananjaya A Hiremath and Dr Smt Lalita D Hiremath. This is a gift
from the authors to all the students. They have covered in this book all topics
required by the medical students. The explanation and descriptions are so
detailed that even the postgraduates can refer.
The book is quite useful to dental, nursing and paramedical students and
public health consultants.
I wish all the best to the authors and they should produce such useful books
for the students in future.
SJ Nagalotimath MD
Medical Director
Preface to the Second Edition
The community medicine subject undergoes frequent changes according to
the needs of the community and to match its dynamic growth, the updating
of the subject is essential. It gives us a great pleasure to present this revised
second edition. Considering mainly the interests of the postgraduate students,
the following topics are updated, viz. Economics, Reproductive and Child
Health, Contraceptive Methods, Immunization, Nutrition, and Hospital Waste
Management.
Newer topics, viz. Integrated Disease Surveillance Project, Integrated
Management of Neonatal and Childhood Illness, National Rural Health
Mission, Community-based Rehabilitation, Indian Systems of Medicine,
Hospital Statistics, and Social Security, are added.
Lalita D Hiremath
Dhananjaya A Hiremath
Preface to the First Edition
We are living in a world different from that of previous generation.
The information superhighway is a reality and has become a tool for instant
sharing of vast amounts of information. This book is written to serve both the
undergraduates and postgraduates to face the practical and viva voce
confidently and derive the maximum benefit from their honest endeavor.
It is generally observed that students face acute difficulties in accurately
answering questions raised in viva voce. The practical portion has been written
in a systemic and lucid manner so as to enable the students to grasp the subject
easily and quickly answer any question to the complete satisfaction of the
honorable examiners.
The book also serves the needs of the dental, nursing and paramedical
students. It is a good tool for the personnel working in the department of
health and family welfare services and public health administrators and
consultants.
Dhananjaya A Hiremath
Lalita D Hiremath
Acknowledgments
We express our deep sense of gratitude to Dr Ashok S Mallapur, Principal,
S Nijalingappa Medical College and HSK Hospital and Research Centre,
Bagalkot, Karnataka, India, for his incessant inspiration and encouragement.
We convey our sincere thanks to Dr TM Chandrashekhar, Dean, HSK Hospital,
Bagalkot, Karnataka, India.
We are thankful to Shri Veeranna Charantimath, the Chairman of BVV
Sangh, who is the visionary and founder of many educational institutions.
We are also thankful to Shri Siddanna Shettar, Chairman, Governing Council
of S Nijalingappa Medical College and HSK Hospital and Research Centre,
Bagalkot, Karnataka, India, who is an eminent educationist and able
administrator.
We convey our sincere thanks to Dr CH Ghattargi, Professor and Head,
and all members of the Department of Community Medicine, S Nijalingappa
Medical College, Bagalkot, Karnataka, India. We are grateful to all the students
and teaching faculty, who have encouraged us to bring the revised second
edition. We also express sincere thanks to Smt Kalpana Kulkarni, who
contributed chapters on Biostatistics. The critical appraisal of the book by
readers is always welcome. We are thankful to M/s Jaypee Brothers Medical
Publishers (P) Ltd, New Delhi, India.
Contents
1. Present Health Status 1-6

Disease Burden 1
Reasons for High Disease Burden 1
Communicable Diseases 2
Chronic Noncommunicable Diseases and Conditions 2
Nutritional Deficiencies 2
Maternal and Child Health 3
Burden of Occupational Diseases and Injuries 3
Clinical Diagnosis and Community Diagnosis 5
Notifiable Diseases 5
2. Family 7-9
Family 7
Definition 7
Types of Family 7
Special Objectives 8
Method of Study 8
FamilyA Dynamic Unit 8
General Information for Students 9
3. Economics 10-15
Poverty Line 10
Per Capita Income 10
Overcrowding 10
Accepted Standards 11
Sex Separation 11
Housing 11
Social Classification 11
4. Communicable Diseases 16-75

Communicable Disease 16
Definition 16
Tuberculosis 18
Sites Affected 18
Economic Burden of Tuberculosis 18
Epidemiological Indices 19
Communicability 19
Case Finding 20
Chemoprophylaxis 21
Treatment 21
Important Definitions 23
xiv Essentials of Community MedicineA Practical Approach
Pediatric Tuberculosis 25
Pediatrics DOTS 25
Directly Observed Therapy Short-course (DOTS) 27
Structure of the RNTCP 28
Reasons for Dropout of the Treatment 29
National TB Control Program 29
Objectives of NTCP (1962) 30
Disinfection of Sputum 30
DOTS-Plus Strategy 30
Green Light Committee Initiative 32
HIV Infection and Risk of Tuberculosis 32
Leprosy 33
History 33
Burden of Leprosy 33
Essential Indicators for Leprosy 34
Epidemiology 35
Lepromatous Leprosy 37
Diagnosis 38
Bacteriological Examination 40
Treatment of Reversal Reaction 44
Treatment of ENL Reaction 46
Completion of Treatment and Cure 46
Leprosy Control 47
Leprosy Control Programs 47
Health Education 48
Rehabilitation 49
Leprosy Organizations in India 49
National Leprosy Eradication Program (NLEP) 50
Modified Leprosy Elimination Campaigns 50
Special Action Projects for the Elimination of Leprosy 51
Global Leprosy Elimination Program 51
Filariasis 52
Burden of Disease 52
Epidemiology 52
Clinical Manifestations 53
Control Measures 53
National Filaria Control Program 54
Diarrhea and Dysentery 54
Definition 54
Dysentery 55
Problem of Diarrheal Disease 55
Cholera 56
Epidemiology 56
Disinfection 62
Diarrheal Diseases Control Program 63
Contents xv
Scabies 66
Epidemiology 66
Clinical Features 67
Complications 67
Variants 68
Control of Scabies 68
Sexually Transmitted Diseases 68
What are Sexually Transmitted Diseases? 68
Why is STD Control an Important Component of HIV/AIDS
Prevention? 68
What are the Symptoms of STDs? 69
How can One Protect Oneself from STDs? 69
How can Reinfection of STDs be prevented? 69
What are the Approaches to STD Management? 70
What is the Syndrome Approach? 70
The Steps Involved in Adopting a Syndromic Approach 71
Syndromic Case Management necessitates Clinical Examination
of the Patient 71
Syndromic Case Management 72
Advantages of the Syndromic Case Management 72
Treatment for the Most Common STD Associated Syndromes 73
National STD Control Program 74
5. Noncommunicable Diseases 76-100

Coronary Heart Disease 76
Definition 76
Measurement the Burden of Disease 77
Epidemiology 77
Risk Factors for CHD 77
Medical Treatment 78
Prevention and Control 79
Population Strategy 79
Hypertension 80
Prevalence 80
Risk Stratification 80
Pharmacologic Treatment Initiation 81
Obesity 82
Prevalence 82
Assessment of Obesity 83
Clinical Features of Obesity 85
Complications 85
Treatment 85
Rheumatic Heart Disease 86
Prevalence 87
xvi Essentials of Community MedicineA Practical Approach
Diagnosis 87
Mental Health 88
Prevalence 88
Classification 89
Etiology 89
Organic Conditions 89
Social Pathological Causes 90
Environmental Factors 90
Warning Signals of Poor Mental Health 90
National Mental Health Program 91
Aims 91
Objectives 91
Strategies 91
Diabetes Mellitus 92
Latent Diabetic 92
Black Zone 92
Clinical Classification of Diabetes Mellitus as Adopted by WHO 92
Epidemiology 93
Environmental Factors 93
Social Factors 93
Complications 93
Investigations 94
Prevention and Care 94
National Diabetes Control Program 95
Objectives 95
Cancer 96
Prevalence 96
Causes of Cancer 98
Environment 98
Genetic 98
Primary Prevention 98
Health Education Regarding Danger Signals 99
Secondary Prevention 99
Treatment for Cancer 99
National Cancer Control Program (NCCP) 99
Basic Steps 99
Goals of NCCP 99
District Cancer Control Program 99
Carcinoma of Breast 99
Carcinoma of Lung 100
6. Maternity and Child Health 101-133

In Developing Countries 101
Causes of Maternal Death 101
Contents xvii
Conceptual Framework of Safe Motherhood 102

Risk Approach 102
Reproductive and Child Health Program 103
Definition of RCH 103
Major Elements of RCH Program 104
Reproductive Health Elements 104
Child Survival Elements 104
State Committee on Voluntary Action 105
Contents of Kits Supplied to Subcenter and First Referral
Unit (FRU) 105
Under RCH Program 106
Methods to Estimate Requirements for MCH Services 107
Antenatal Care 107
Objectives of Antenatal Visit 107
Specific Protection 108
Maternal and Child Health 108
RCH-II and Family Planning 108
Program Implementation Plan (PIP) 109
Janani Suraksha Yojana 109
Mamta SchemeAn Example of Public Private Partnership in
Health Care 111
Health Care Services for the Beneficiaries under the Scheme 112
Eligibility Criteria for Beneficiaries under the Scheme 112
Registration of Beneficiaries under the Scheme 112
Prevention of Patient to Child Transmission (PPTCT) 112
Role of Maternal and Child Health Services in the Prevention of
HIV Infection in Infants and Young Children Program. 113
Integration of PPTCT within Postnatal MCH Services 114
Key Points 114
Infant Feeding Formula 115
Intranatal Care 116
Care at Birth 116
Postnatal Care 116
Objectives of Postnatal Care 116
Warm Chain 117
High-Risk Infants 117
Malnutrition 117
Definition 117
Classification 117
Nutritional Problems 118
Epidemiology 118
Protein-Energy Malnutrition 119
Definition 119
Types of PEM 119
Signs 120
xviii Essentials of Community MedicineA Practical Approach
Classification of PEM 120

Epidemiology of Malnutrition 122
Examination of the Case 124
Weighing Procedure 124
Height or Length 126
Midarm Circumference 128
Head and Chest Circumference 129
General Procedures for Treatment of Severe PEM 129
Calculation of Expected Weight of the Child 131
Calculation of Expected Height of the Child 132
Surface Area According to Weight 132
Calculation of Pediatrics Doses 132
Breastfeeding 132
A to Z Benefits for Baby 132
Advantages to Mother 132
7. Reproductive and Child Health 134-154

Qualities of Good Contraceptives 134
Methods of Family Planning 136
Emerging Oral Contraception 142
Give Specific Instructions 143
Important 144
Give Advice on Common Problems 144
Explain Specific Reasons to Return to the Health Care Provider 144
Introduction to Injectable Contraceptives 145
Mechanism of Action 145
Advantages and Disadvantages of Injectable Contraceptives 145
Subcutaneous DMPA and Home Injection 147
Centchroman 147
Family Planning Insurance Scheme 148
Medical Methods of Abortion 149
Mifepristone and Misoprostol 149
Future Fertility 150
Manual Vacuum Aspiration (MVA) 150
Methods of Uterine Evacuation 150
Calculation of the Effective Couple Protection Rate (ECPR) 152
Effective Protection 152
Pearl Index 153
Important Facts about Contraceptives 153
8. Immunization 155-187
National Immunization Schedule 155
Immunization of Pregnant Woman 155
Determine Needs and Requirement 156
Difference between EPI and UIP 157
Estimation of Requirements of Syringes and Needles 158
Contents xix
Estimation of Requirements of Sterilization Equipment 159

Estimation of Vaccine Needs 159
Estimation of Cold Chain Requirements 160
Determine Training Needs 161
Estimation of Requirements of Immunization Cards 162
Estimation of Vaccine Requirements 162
Maintain Vaccines 164
Maintain Equipment 165
Vaccine 166
Oral Polio 168
Development of Immunity 168
Strategies for Polio Eradication 170
Current Four Basic Strategies to Eradicate Polio 170
National Immunization Days 171
Intensive Pulse Polio Immunization (IPPI) 175
Vaccine Vial Monitoring 176
Measles Vaccine 176
Adverse Effects of Vaccine 177
Combined Vaccine 178
Urban Measles Campaign 178
Diphtheria Immunization 178
Composition of DPT Vaccines 179
Tetanus Toxoid 180
Active and Passive Immunization 182
Elimination of Neonatal Tetanus 182
Anti-Rabies Vaccine 182
Anti-Snake Venom 184
Newer Vaccines 185
9. Nutrition 188-214
Dietetics 188
Balanced Diet 188
Assessment of Nutritional Status 190
Assessment of the Energy Requirement for Family 191
Cereals and Millets 191
Pulses (Legumes) 192
Fruits 194
Nuts and Oil Seeds 195
Nutrient Requirements during Pregnancy 196
Rich Sources of Essential Nutrients 199
Protein Requirements 200
Principles in Calculating Balanced Diet 200
Balanced Diets 200
Balanced Diet for Children 201
Average Weight of Vegetables 204
xx Essentials of Community MedicineA Practical Approach
Approximate Weight of Foods Equal to 1 Level Katori (Bowl) of

150 ml Volume 205
Average Weight of Nuts and Spices 205
10. Medical Entomology and Worm Infestations 215-227
Arthropods 215
Arthropods of Medical Importance 215
Mosquito 217
Mosquito-borne Diseases 217
Mosquito Control Measures 220
Ticks 220
Houseflies 221
Public Health Importance of Worm Infestation 224
Ascariasis 224
Enterobius vermicularis 225
Trichuris trichiura 225
11. Disinfection 228-233

Definitions (Disinfectant or Germicide) 228
Disinfectant 228
Antiseptic 228
Deodorant 228
Detergent 228
Sterilization 228
Disinfection 228
Types of Disinfection 229
Disinfecting Agents 229
Natural Agents 230
Physical Agents 230
Chemical Disinfectants 231
12. Insecticides and Rodenticides 234-237

Insecticides and Pesticides 234
Classification 235
DDT (Dichloro-diphenyl-trichloroethane) 235
HCH (BHC) Hexachlorocyclohexane 236
Malathion 236
Mineral Oil 236
Paris Green (Copper aceto-arsenite) 237
13. Environmental Models 238-245

Chloroscope/Chlorinometer 238
Procedure 238
Dry and Wet Bulb Thermometer (Hygrometer) 238
Procedure 239
Maximum and Minimum Thermometer 239
Procedure 239
Kata Thermometer 240
Contents xxi
Used for Measuring 240

Procedure 240
Globe Thermometer 240
Procedure 240
Sling Psychrometer 241
Procedure 241
Gully Trap 242
Soak Pit 242
Slow Sand Filter 244
Rapid Sand Filter 245
14. Water Analysis 246-252

Determination of Total Hardness 246
Theory 246
Procedure 246
Bacteriology of Water 247
Bacteriological Examination of Water 247
Steps in Well Disinfection 250
Find the Volume of Water in a Well 250
Find the Amount of Bleaching Powder Required for
Disinfection 250
Procedure 251
Dissolve Bleaching Powder in Water 251
Delivery of Chlorine Solution into the Well 251
Contact Period 251
Orthotolidine Arsenite Test 252
15. Bacteriology of Milk 253-254

Bacteria in Milk 253
Types of Bacteria in Milk 253
Bacteriological Examination 253
Staining, Culture Media and Microscopy of Slides

16. 255-263
of Public Health Importance
Gram Stain 255
Aim 255
Requirement 255
Procedure 255
Result 255
Ziehl-Neelsen Stain 256
Aim 256
Procedure 256
Result 256
Albert Stain 256
Aim 256
Requirement 256
Procedure 257
Result 257
xxii Essentials of Community MedicineA Practical Approach
Culture Media 257

Types of Media 257
Microscopic Slides 258
Mycobacterium tuberculosis 259
Mycobacterium leprae 259
Treponema pallidum 259
Neisseria meningitidis 260
Corynebacterium diphtheriae 261
Neisseria gonorrhoeae 261
Clostridium tetani 261
Leptospira 262
17. Hospital Waste Management 264-279

Type of Hospital Waste 265
Hazards and Risks from Hospital Waste Exposure 266
Hospital Waste Disposal 266
Categories of Biomedical Waste 267
Objectives of Plan 268
Planning and Organization 268
Organization 269
Staff Appraisal on Hospital Waste Management 269
Waste Disposal Strategy 270
Incinerators 272
Site for Incinerator 272
Standards for Incinerators 272
Inertization 276
Legislative Framework 276
Summary of Biomedical Waste Rules 276
What You should Know and Do 277
18. National Rural Health Mission (2005-2012) 280-296

Goals 281
Strategies 281
Core Strategies 281
Supplementary Strategies 282
Plan of Action 282
Component (A): Accredited Social Health Activists 282
Component (B): Strengthening Sub-Centers 283
Component (C): Strengthening Primary Health Centers 283
Component (D): Strengthening CHCs for First Referral Care 284
Component (E): District Health Plan 284
Component (F): Converging Sanitation and Hygiene under
NRHM 284
Component (G): Strengthening Disease Control Programs 285
Component (H): Public-Private Partnership for Public Health
Goals, including Regulation of Private Sector 285
Component (I): New Health Financing Mechanisms 285
Component (J): Reorienting Health/Medical Education to
support Rural Health Issues 286
Contents xxiii
Institutional Mechanisms 286

Technical Support 287
Program Management Support Center 287
Health Trust of India 287
Role of State Governments Under NRHM 288
Focus on the North-Eastern States 288
Role of Panchayati Raj Institutions 288
Role of NGOs in the Mission 289
Mainstreaming Ayush 289
Funding Arrangements 289
Timelines (for Major Components) 290
Outcomes 290
National Level 290
Community Level 291
Monitoring and Evaluation 291
Is NRHM a New Program of the Government of India? 292
What is the Institutional Setup at National, State and District
Levels? 292
National Urban Health Mission 292
Goal 293
Core Strategies 293
Components of Urban Health Mission (UHM) 293
Targets 294
Urban Health Delivery Model 294
At Community Level (Urban Social Health Activist, USHA) 294
Essential Service to be Rendered by the USHA 294
Primary Urban Health Center 295
19. Sanitation of Camps 297-301

Camp Site 297
Accommodation and Equipment 298
Water 298
Food and Cooking Arrangements 298
Disposal of Refuse and Excreta 299
Dry Camp and Kitchen Refuse 299
Liquid Waste 299
Disposal of Feces 300
Disposal of Stable Litter 301
20. Indian Systems of Medicine 302-307
Ayurveda System of Medicine 302
Siddha System of Medicine 303
Introduction and Origin 303
Basic Concepts 303
Diagnosis and Treatment 303
Unani System of Medicine 304
Origin and Development 304
Fundamental Principles 304
Diagnosis and Treatment 304
Homeopathy 305
xxiv Essentials of Community MedicineA Practical Approach
Yoga 306
Naturopathy 307
Allopathy 307
Methods 307
21. Adolescent Health 308-315

Population Profile: Ages 10 to 24 Years in India 308
Characteristics 308
Physical Changes during Adolescent 309
Puberty Changes in Adolescent 310
Puberty in Girls 310
Psychological and Behavioral Changes 310
Impact of Adolescence 310
Adolescent Health Problems 311
Emotional Problems 311
Educational Problems 311
Reasons for Adolescent Reluctant to seek Help 312
Prevention 312
Syllabus for Adolescent Health Education 312
Life Skills 312
Adolescent Friendly Health Center Services 313
Criteria for Adolescent Friendly Health Worker 313
Criteria for Adolescent Friendly Health Center 313
Adolescent Girls Scheme 314
Beneficiaries 314
Scheme I: Girl-to-Girl Approach 314
Scheme II: Balika Mandal 314
Interventions 315
Training 315
22. Integrated Disease Surveillance Project 2004-2009 316-334

Project Objectives 316
Specific Objectives 316
Phasing of IDSP Covering the States of India 316
Project Activities 317
Sentinal Surveillance under IDSP 317
Regular Periodic Survey 317
National Surveillance Unit 318
State Surveillance Unit 318
District Level Unit 318
District Surveillance Unit 318
Functions of the District Surveillance Unit 318
District Epidemiological Cell 320
Levels of Response to Different Triggers 321
Malaria Triggers 322
Cholera Triggers 322
Typhoid Fever Triggers 322
Contents xxv
Polio Trigger 322

Plague Triggers 323
Japanese Encephalitis Triggers 323
Dengue Triggers 323
Triggers for Syndromic Surveillance 323
Surveillance of Noncommunicable Diseases 332
Aims 332
NCD Risk Factors 332
Program for Control and Treatment of
Occupational Diseases 332
List 332
Etiological Classification of Occupational Disorders 332
Proposed Projects for Occupational Diseases under National
Program for Control and Treatment of Occupational Diseases 333
Global Strategy of Occupational Health 333
Monitoring and Evaluation 334
23. Integrated Management of Neonatal and Childhood Illnesses 335-338

Components of IMNCI in India 335
IMNCI Strategy in India 335
Timeline of IMNCI 337
The IMNCI-PLUS 338
24. Community-Based Rehabilitation 339-345

Hard Facts 339
Need of Rehabilitation Service 340
Seven National Levels Institutes 340
Government Rehabilitation Services 340
Objectives 340
District Rehabilitation Center (DRC) Project 340
Regional Rehabilitation Training Center (RRTC) 341
National Information Center on Disability and Rehabilitation
(NICDR) 341
Role of Primary Health Centers for Disability Rehabilitation 342
Model Method of Implementation of CBR Using Primary Health
Centers 343
Orientation of Medical Officers Working in Primary Health
Centers to Disability Management 344
Expected Benefits of the Program 345
25. Social Security 346-349

Workforce in India 346
Organized and Unorganized Sectors 346
Functions of Social Security Division 347
List of Subjects 347
New Initiative in Social Security 349
xxvi Essentials of Community MedicineA Practical Approach
26. Swine Flu 350-352

Transmission 350
Signs and Symptoms 351
Cause of Death 351
Facility Management 351
Herd Management 351
27. Hospital Statistics 353-355

Daily Analysis 353
Monthly Reports 353
Census 353
Death Rate 353
28. Biostatistics 356-377
Definitions of Statistics 356
Use of Biostatistics 357
Collection and Presentation of Data 357
Frequency Table 358
Graphical Representation of Data 358
Graphs 358
Bar Diagram 358
Histogram 359
Frequency Polygon 360
Pie Diagram 360
The Ogive 360
Centering Constants (Measures of Central Tendency) 361
Arithmetic Mean 361
Median 362
Mode 362
Measures of Variation 362
Range 362
Mean Deviation (MD) 363
Standard Deviation (SD) 363
Coefficient of Variation (CV) 363
Quartile Deviation (QD) 363
Percentile 364
Tests of Statistical Comparison of Two Groups 364
Test of Significance (for Large Size) 364
Test of Significance (for Small Sample Size) 366
t-tests for Unpaired Data 366
t-tests for Paired Data 367
Steps for Paired t-test 367
Standard Error of Proportion (Large Sample Size) 367
Standard Error of Difference between Two Proportions (Large
Sample) 368
Probability of a Larger Value of t 369
Normal Distribution 370
Contents xxvii
Table of the Unit Normal Distribution 371

Chi-square Test (-Test) 372
Table of Chi-square 372
Formula 373
Fallacies in Biostatistics 373
Vital Statistics 374
Geometrical Progression Method 374
Measures of Vital Statistics 374
International Death CertificateCause of Death 377
29. Problems 378-407
Environmental Problems 378
Problems 378
Biostatistics 381
Limitations of the Mean 384
Correlation and Regression 387
Problems 389
Demography 392
Epidemiological and Nutritional Exercises 399
Miscellaneous Problems 404
30. Visits 408-434

Integrated Counseling and Testing Center (ICTC) 408
Visit to Blind School 409
Admission Criteria 409
Government Authority 409
National and International Agencies 410
A Visit to Deaf and Dumb School 410
Staffing Pattern 411
Rules and Regulations 411
Visit to District Health Laboratory 411
Functions 411
Visit to Primary Health Center (PHC) 412
Functions of the PHC 412
Postpartum Center 413
Functions of Postpartum Unit 414
Department of Obstetrics and Gynecology 415
Monitoring and Evaluation Aspects 415
Broad Functions 416
Delivery of Integrated Services for Maternal and Child Health,
Family Planning, Nutrition and Immunization 416
The Baby Friendly Hospital Initiative 417
What is BFHI? 417
Why this Program? 417
What is New About it? 417
xxviii Essentials of Community MedicineA Practical Approach
What is this Program All About? Can it be Simply

Described in a Few Words? 418
What are the Benefits of Making My Hospital Baby Friendly? 418
What are the Investments Needed and What is the Cost
Involved? 419
What should I do to get My Hospital Recognized as
Baby Friendly Hospital? 419
World Breastfeeding Week 419
What are Our Problems? 419
Anganwadi 421
Integrated Child Development Scheme 421
Objectives 422
Organizational Set-up 422
Visit to District Tuberculosis Center 425
National Tuberculosis Program (NTP) 425
Visit to District Rehabilitation Center 426
Services Provided 426
National Program for Rehabilitation of Persons with
Disabilities 427
Visit to Places of Natural Calamities 427
Disasters 427
School Health Service 430
Benefits of School Health Programs 430
Objectives of School Health Service 431
School Health Program in India 431
Aspects of School Health Service 431
Visit to District Leprosy Center 432
District Infrastructure 432
Goal of National Health Policy 2002Elimination of
Leprosy by 2005 433
Appendix ...................................................................................................435
Index ..........................................................................................................447
Introduction
COMMUNITY MEDICINE
Community medicine is comparatively a newcomer among academic
disciplines of medicine. Previously it was taught to medical students as hygiene
and public health. This name was later changed to preventive and social
medicine when it was realized that the subject encompassed much more than
merely the principles of hygiene and sanitation and public health engineering.
The name preventive and social medicine emphasizes the role of: (a) disease
prevention in general through immunization, adequate nutrition, etc. in
addition to the routine hygiene measures and (b) social factors in health and
disease. The modern day message is that the discipline variously labeled in
the past as public health or preventive and social medicine cannot be divorced
from health care, including clinical care of the community. It is in recognition
of this wider role that the Medical Council of India has recently decided to
label the discipline as Community Medicine in place of Preventive and Social
Medicine.
CHALLENGES OF 21ST CENTURY

Challenges of 21st century are not only to combat diseases producing microbes
but also to recognize that many of the causes of ill health are increasingly
related to lifestyle, man-made changes in environment, and disparity and
inequality in resources distribution within country and between the countries.
Developed world is facing epidemiological transition that is transition from
infectious diseases as measles, diphtheria, and pneumonia to chronic diseases
as heart diseases, cancer, stroke and diabetes, which consisted 9 out of 10
leading causes of deaths. This transition is mainly due to improved water
supply, sewerage, and less crowded living environment, application of the
preventive health services, such as immunization, preventive health check-
ups, specific food interventions and use of highly developed curative
technology.
Now, developing countries are experiencing the double burden of diseases,
i.e. one which is caused by poverty, poor water supply and sanitation and
low standard of livings and other which is due to adopting similar lifestyles
as of developed world.
Another important concern is the world population that has increased three-
fold in last century whereas India has increased almost five times in the same
duration. The number of persons living in urban areas increased globally from
32 percent of world population in 1955 to 38 percent in 1975, and to 45 percent
in 1995. It is expected to reach 54 percent by 2015 (World Health Report 1998).
xxx Essentials of Community MedicineA Practical Approach
In India, the urban population during 1911-1931 was 11-12 percent only and
in 1951 was 17.3 percent only, however, in 1991 it reached to 25.7 percent and
it is estimated 31 percent in 1996-97 and it was going to be 38 percent in
2006-07.
Chapter
1 Present Health Status
CHAPTER OUTLINE
DISEASE BURDEN REASONS FOR HIGH DISEASE BURDEN IN INDIA
COMMUNICABLE DISEASES CHRONIC NONCOMMUNICABLE DISEASES AND CONDITIONS
MATERNAL AND CHILD HEALTH NOTIFIABLE DISEASES
DISEASE BURDEN
It has been estimated that the disease burden of the people of India is
one of the highest in the world (Table 1.1). We have a triple burden of
infectious diseases. Firstly, we have those infectious diseases that are
prevalent worldwide and for which specific preventive measures are
yet not available. Secondly, we have infectious diseases that are prevalent
because of insufficient public health measures. Thirdly, we have infectious
diseases perpetuated by the prevalence of vectors (hematophagous
arthropods) as well as vertebrate fauna, the ecological determinants of
which are given due to our geoclimatic features.
REASONS FOR HIGH DISEASE BURDEN
1. Poor economy of the country
2. Maldistribution of country resources
3. Poor governance and management to utilize resources appropriately
4. Poor people participation.
Table 1.1: Ten leading causes of burden of disease,world, 2004 and 2030
2004 As % of Rank Rank As % of 2030
Disease or injury total total Disease or injury
DALYs DALYs
Lower respiratory infection 6.2 1 1 6.2 Unipolar depressive disorders
Diarrheal diseases 4.8 2 2 5.5 Ischemic heart disease
Unipolar depressive disorders 4.3 3 3 4.9 Road traffic accidents
Ischemic heart disease 4.1 4 4 4.3 Cerebrovascular disease
HIV/AIDS 3.8 5 5 3.8 COPD
Cerebrovascular disease 3.1 6 6 3.2 Lower respiratory infections
Prematurity and low birth weight 2.9 7 7 2.9 Hearing loss, adult onset
Birth asphyxia and birth trauma 2.7 8 8 2.7 Refractive errors
Road traffic accidents 2.7 9 9 2.5 HIV/AIDS
Neonatal infections and other* 2.7 10 10 2.3 Diabetes mellitus
COPD 2.0 13 11 1.9 Neonatal infections and other
Refractive errors 1.8 14 12 1.9 Prematurity and low birth weight
Hearing loss, adults onset 1.8 15 15 1.9 Birth asphyxia and birth trauma
Diabetes mellitus 1.3 19 18 1.6 Diarrheal diseases
COPD, chronic obstructive pulmonary disease
*This category also includes other noninfectious causes arising in the perinatal period apart from prematurity,
low birth weight, birth trauma and asphyxia. These noninfectious causes are responsible for about 20% of
DALYs shown in this category.
2 Essentials of Community MedicineA Practical Approach
5. Poor level of literacy of the people

6. Geographical characteristics of the country for certain diseases like
malaria, filaria, etc.
7. Poor political commitment
8. Poor policy
9. Poor scientific development
10. Religious belief system and cultural practices of the population.
COMMUNICABLE DISEASES
About 17 percent of all deaths and about 21 percent of all illnesses are
due to communicable diseases. The major problems continue to be
tuberculosis, filariasis, leprosy, malaria, diarrheal diseases and
malnutrition.
Among viral diseases smallpox was eradicated in 1980. Measles
continues to be rife frequency in occurrence, and so is viral hepatitis.
Since 1973, the country has been experiencing large scale outbreaks of
Japanese encephalitis. Dengue fever is also emerging as another health
problem.
Among bacterial diseases meningococcal meningitis has shown a
substantial increase. Cholera has significantly declined, but the other
waterborne diseases (e.g. acute diarrheas, dysentery and enteric fever)
have not abated. Half the worlds tuberculosis patients are in India
accounting for 14 million cases of which in the world, estimated to be
0.6 million. Tetanus and Diphtheria are not yet under control.
The country has one-third of leprosy cases. Among parasitic diseases,
Malaria and Kala-azar have staged a comeback. During 1995, 3 million
cases of malaria and 22,000 cases of Kala-azar were reported. About
420 million people are estimated to be living in known endemic areas of
Filariasis.
Intestinal parasites such as ascariasis, hookworms, giardiasis and
amoebiasis are widely prevalent. STDs are on the increase.
CHRONIC NONCOMMUNICABLE DISEASES AND CONDITIONS

Noncommunicable diseases such as hypertension, diabetes, cancer, road
accidents, alcohol drug abuse and mental health problems are slowly
emerging as health problems. One reason for this appears to be changes
in lifestyle and growing stresses of urban life.
The Table 1.2 shows the percentage (approximately) of major causes
of all deaths in developing countries.
Nutritional Deficiencies
Nutritional deficiencies are widespread and include protein energy
malnutrition, vitamin deficiency, vitamin B complex deficiency, nutritional
anemia and iodine-deficiency disorders. Undernutrition affects millions
Present Health Status 3
of people. In 1992, about 30 percent of babies were born with birth

weight of less than 2.5 kg.
Table 1.2: The percentage (approximately) of major causes
of all deaths in developing countries
Case Years
1985 2000
Infections 35 25
Neoplasm 7 10
Circulatory diseases 20 30
Injuries 8 6
Recent trends with regard to nutritional status of women and children

in India have been positive and modest. The improvement has been
marked with respect to the prevalence of severe malnutrition. Even
with respect to moderate undernutrition modest improvements in
anthropometry and birth weight have been noticeable even amongst
the poor.
MATERNAL AND CHILD HEALTH

By virtue of the large group (Women 22% Children 38% together
constitute 60%) of total population and also vulnerable or special risk
group mother and children are the major consumer of health services.
Tables 1.3 and 1.4 show the poor status of MCH (Maternal and Child
Health).
Burden of Occupational Diseases and Injuries

There are 100 million occupational injuries causing 0.1 million deaths in
the world according to WHO (Leigh et al 1999). It is also estimated that
in India 17 million occupational nonfatal injuries (17% of the world) and
45,000 fatal injuries (45% of the total deaths due to occupational injuries
in world) occurs each year. Out of 11 million cases of occupational
diseases in the world 1.9 million cases (17%) are contributed by India
and out of 0.7 million deaths in the world 0.12 (17%) is contributed by
India.
Table 1.3: Health facilities in India
India
Population 2001 [Million] 1028.6 1
Projected population 2010 [Million] 1176.7 1
Health care infrastructure
Community health centers 4276 2
Primary health centers 23458 2
Subcenters 146036 2
Total FRUs 1813 2
Contd...
Contd...
India
CHCs owned building 3882 2
PHCs owned building 19706 2
SCs owned building 78803 2
Manpower status
Total allopathic doctors 725190 3
Total allopathic doctors in Govt 84852 3
Total dentist 73057 3
Total dentist in govt sector 3233 3
Total ayurvedic doctors 458418 3
Total registered ANMs 549292 3
Total ANMs in govt 153568 2
Total registered GNMs 971574 3
Total registered LHVs 51497 3
Total specialist at CHCs 4279 2
MBBs doctors at PHCs 24375 2
Health care indicators
Doctor population ratio [per 1000] 0.633
Doctor nurse ratio 0.463
Nurse population ratio [per 1000] 1.373
Bed population ratio 0.874
Population per subcenter ratio 7838 2
Population per PHC 48799 2
1 2 3 4
Census of India RHS-08 NPH-08 CBHI
Table 1.4: Health status in India

Infants mortality rate 53 2
Maternal mortality ratio 254 2
Total fertility rate 2.72
Crude birth rate 22.82
Crude death rate 7.42
Life expectancy 66.91
Under 5 mortality rate 74.33
ANC-3 check ups (%) 52 3
I and FA Tab. received for 90 days % 23 3
Two TT Inj. received in last preg % 72 3
Birth in medical institutions (%) 49 3
BCG (%) 78 3
Polio 3 doses (%) 78 3
DPT3 (%) 55 3
Measles (%) 59 3
1 2 3
Census of India NHP-08 SRS-08
Present Health Status 5
Clinical Diagnosis and Community Diagnosis (Table 1.5)

Table 1.5: Comparative model of clinical diagnosis and community diagnosis
Clinical diagnosis Community diagnosis

Sick patient Sick community
Patient decides to consult doctor Community feels the need for consulting
professionals
Visits doctor Professions and community interaction
Doctor takes history and symptomology Studies community history, hospital
record, birth,death, notification analysis
Provisional diagnosis Community provisional diagnosis,
(Identify community problems)
Decides which system to examine and Decides what type of exploration or
what type of investigations to be performed studies to be conducted in the community
Carry out clinical examination Carry health surveys,screening for
and investigations diseases surveillance
Scrutiny, analysis and interpretation Scrutiny, analysis and
clinical examination and laboratory results interpretation of data
Arrives at clinical diagnosis Makes community diagnosis
Decides treatment and advice Decide on community treatment or
community action on priorities.
Administers the treatment and Plans and implements community
give advices service and program
Monitor of follow-up of the patient Monitor community change, reduction in
(Symptomatic improvement, etc) morbidity, mortality, etc. (Evaluation)
If no improvement change the If no improvement, change or
treatment regimen modify plan of action
NOTIFIABLE DISEASES
A disease that, by statutory requirements, must be reported to the public
health authority in the pertinent jurisdiction when the diagnosis is made.
Following are the notifiable diseases:
1. Lead poisoning or its sequelae.
2. Lead tetraethyl poisoning to its sequelae.
3. Phosphorus poisoning or its sequelae.
4. Mercury poisoning or its sequelae.
5. Manganese poisoning or its sequelae.
6. Arsenic poisoning or its sequelae.
7. Poisoning by nitrous fumes.
8. Carbon bisulfite poisoning.
9. Benzene and its derivatives poisoning or its sequelae.
10. Chrome ulceration or its sequelae.
11. Anthrax.
12. Silicosis.
13. Poisoning by halogens or its derivatives of hydrocarbons.
14. Pathological manifestation due to radium, radioactive substances,
or X-rays.
15. Primary epitheliomatous cancer of the skin.
16. Toxic anemia.

17. Toxic jaundice due to poisonous substances.
18. Oil acne or dermatitis due to mineral oil or its derivatives in any form.
19. Byssinosis.
20. Asbestosis.
21. Occupational or contact dermatitis caused by direct contact with
chemical or paints. It could be primary irritants or allergic sensitizers.
22. Noise induced hearing loss.
23. Beryllium poisoning.
24. Carbon monoxide.
25. Coal miners pneumoconiosis.
26. Phosgene poisoning.
27. Occupational cancers.
28. Isocyanates poisoning.
29. Toxic nephritis.
Chapter
2 Family
CHAPTER OUTLINE
FAMILY
GENERAL INFORMATION FOR STUDENTS
FAMILY
Each student will be assigned families in the village. The objective of
this program is to provide opportunities to the medical student to learn
that the family is the basic unit for epidemiological studies and obtain practical
experience in the health promotion, early diagnosis and treatment,
disability limitation and rehabilitation.
Definition
Family is a group of individuals, who are related by blood or marriage,
live under same shelter and share common kitchen.
Types of Family
There are four basic types of families:
Nuclear Family
When the family unit consists of husband, wife and children it is called
nuclear family. Relationships of married couple in this type of family are
more intimate than in other types of families. Nuclear family is mostly
male dominated.
Polygamous type of nuclear family: It is made up of a husband, two or more
co-wives and the children.
Polyandrous type: In some communities polyandrous type of families exists.
This consists of wife, two or more co-husbands and the children. All
family members either live in one house or each co-wife/co-husband
occupies separate house. These houses (or huts) are usually within family
compound or homestead. In most societies polygyny is socially
permitted.
Extended Family
This type of family can be considered as a vertical extension of nuclear
family. Thus, a small extended family consists of the old man, his wife,
their sons, the sons wife and the sons children. Here the married son is
a member of two nuclear families, his fathers and his own. A large
extended family, for example, may consist of, the old man, his wives,
their unmarried children, married sons, sons wives (each son having
one or more wives) along with their unmarried children.
Joint Family
This family can be considered as lateral extension of nuclear family. It
consists of nuclear families of siblings (brothers in patrilocal system and
sisters in matrilocal system), eldest brother/sister has the position of
authority.
Three Generation Family

This is similar to joint family, but the reason for married son living with
the parents is economical and not social.
Special Objectives
1. To study the family composition.
2. To study and observe environmental factors having their influence
on the health and disease of the family members.
3. To study and observe social and economic factors associated with
health and disease.
4. To observe the growth and development of the family.
5. To study the health status of the family members.
6. To study and followthe morbidity encountered in the family and
to learn the importance of observing the patient in his natural
surroundings.
7. To learn the multiple factors associated with the cause of disease
and in getting the treatment.
8. To study the mortality in the family.
9. To study the attitudes and practices of people towards health.
Method of Study
a. Observation
b. Questioning
c. Clinical examination
d. Investigation at field level.
Familya Dynamic Unit

Family Cycle
Family is not a static unit. It is a dynamic unit. Four stages are described
in family cycle.
Family 9
Stage of formation: This stage begins with marriage.

Stage of growth: In this stage, the family grows due to procreation.
Stage of retraction: In this stage, there is reduction in the size of family.
This is due to members leaving family due to marriage or due to death.
It may also be due to married children forming a separate family.
Stage of disintegration: The original family looses its existence due to death
of the couple which formed the original family.
All these stages may not follow the above sequence. Some may occur
simultaneously. In joint and extended family the stage of retraction does
not exist.
GENERAL INFORMATION FOR STUDENTS

1. In the family record, the details of the following done should be
recorded namely immunization, environment, socioeconomic survey,
diet survey, health check-up and annual family morbidity, etc.
2. In family record dead members (in last one year only) in household
should also be recorded at the end with appropriate heading in the
first column of living family members. The cause of death should be
recorded in the Remarks Column. Any members dying during
our care should be recorded.
3. A child under 1 year is not taken into account of while calculating
for overcrowding, a child above 1 year but under 10 years is reckoned
as a half unit.
4. Economic status should be enquired only when you have gained the
confidence of the family.
5. In recording diet, note down seven days typical diet of the family.
Weigh it and calculate the calories, proximate principles, vitamins
and trace elements, etc.
6. Health knowledge should be assessed for common communicable
diseases, diet, infant feeding, contraception, family planning, etc.
7. Past illness should be enquired for all infectious diseases.
8. While doing general physical examination look for the early signs of
chronic diseases, common deficiency, skin infections, diseases
prevalent in the family and treat them under the guidance of the staff.
9. For antenatal examination of the pregnant lady and examination of
infants make an appointment in consultation with Public Health
Nurse.
10. You will present your family study to the class, bringing out all the
important features of environment, the growth and development of
children in the family, common diseases in the family members, their
problems and how you have helped them. The outlines for guidance
are also provided.
Chapter
3 Economics
CHAPTER OUTLINE
POVERTY LINE PER CAPITA INCOME
OVERCROWDING
POVERTY LINE
Poverty line is generally defined in terms of minimum per capita consumption
level of the people. As per the definition given by the Planning Commission,
this level is the caloric intake of people. Thus, poverty line refers to the
cut off point of income below which people are not able to purchase
food sufficient to provide 2400 kcal per head per day. This income level
has been fixed by the Planning Commission at Rs 356.35 per head in
rural areas and Rs 538.60 (January 2010) in urban areas at 1987-88 prices.
Definitions and methodologies used for estimating poverty line differ
from one source to other. According to the sixth five-year plan document,
A family having five members, whose annual income is less than
Rs 3500 is said to be living below poverty line. This income limit was
increased to Rs 6400 in the seventh plan. It was further raised to Rs 7200
as per the eighth plan document.
PER CAPITA INCOME
It is the per head income of the people of a country. It is calculated by
dividing the national income of a country by its population.
Per capita income = National Income/Total population
Increase in the national income may not necessarily lead to an increase
in the per capita income if there is a corresponding increase in population.
The per capita income is the best indicator of measuring the standard of
living of the people of a country. It provides an index of economic welfare.
Per capita income (1997-1998) Rs. 13,193
OVERCROWDING
Degree of overcrowding can be best expressed as the number of persons
per room, i.e.
Number of persons in household
=
Number of rooms in the dwelling
Economics 11
Accepted Standards
1 Room 2 persons
2 Rooms 3 persons
3 Rooms 5 persons
4 Rooms 7 persons
5 Rooms or more 10 persons
(Additional 2 persons for each further room)
Floor Space Accepted Standard

110 sq ft 2 persons
90-100 sqft 1 persons
70-90 sq ft 1 person
50-70 sq ft person
Under 50 sq ft Nil
(A baby under 12 months is not countedchildren between 1-10 years
counted as half a unit)
Sex Separation
Overcrowding is considered to exist if two persons over nine years of
age, (not husband and wife) of opposite sexes are obliged to sleep in
same room.
Housing
Housing Standards
Floor: The floors should be damp proof and free from cracks. The height
of the plinth should be 2 to 3 feet.
Roof: The height of the roof should be minimum of 10 feet from the
surface of floor.
Windows: Should be placed at a height of 3 feet above the ground level.
Window area should be 1/5th of the floor area.
Doors and windows combined should have 2/5th the floor area.
Lighting: The day light factor should exceed one percent of the floor
area.
Cubic space: The height of the room should be such as to give an air space
of at least 500 cft. per capita, preferably 1000 cft.
Living rooms: At least two rooms, one of which can be closed for security.
Social Classification
Methods of Social Classification
Prasads method: This method is proposed by BG Prasad and is based on
per capita income of family. It is useful for social classification of family
and not for individuals. While using this classification it is necessary to

update the value of rupee by applying appropriate correction factor.
Correction factor is obtained by multiplying AICPI by 4.93 percent
3
(i.e. 0.0493) as suggested by Kumar . This is preferred for rural areas.
This is modified BG Prasads social classification (Table 3.1).
= Per capita family monthly income of
1961 (as suggested by BG prasad) correction
factor (CF)
Total monthly income of the family
Where, per capita monthly income =
Total members of the family
CF = Value AICPI, (Which is variable and it was Rs 741 in July 2009)

multiplied by 0.0493, which is a finite number/multiplier (linking factor).
Therefore, CF during July 2009 was 741 0.0493 = 36.53
Table 3.1: Assessment of socioeconomic status by modified BG Prasads classification
BGP classification 1961 Modified BGP Socioeconomic class
based on per capita classification for the status
monthly income CF Year 2009 (July)
Rs 100 and above 36.53 Rs 3653 and below I
Rs 99 to 50 36.53 Rs 3652 to 1826 II
Rs 49 to 30 36.53 Rs 1825 to 1096 III
Rs 29 to 15 36.53 Rs 1095 to 548 IV
Rs 14 and below Rs 547 and below V
Note:
i. Rs 100 during 1961 is equivalent to Rs 3653 during July 2009.
ii. Per capita family monthly income of today (as assessed by the above
formula) has to be fitted in the second column and assessed
accordingly.
iii. All India consumers price Index (AICPI) is variable.
Thus, classification can be derived for any period by referring AICPI of
that period.
Kuppuswamys method: Kuppuswamys socioeconomic status is an
important tool in hospital and community based research in India. It
was proposed in 1976.1 This scale takes account of education, occupation
and income of the family to classify study groups into high, middle and
low socioeconomic status. As pointed out rightly by Mishra and Singh2
from Rewa, An income scale usually has relevance only for the period
under study. Due to the steady inflation and consequent fall in the value
of the rupee, the income criteria in the scale lose their relevance. Mishra,
therefore, undertook important task of revision of family income per
month (in Rs.) for 1976 when the price index was 296 according to base
year 1960=100 (Table 3.2). He however revised it for 1998 using base
year 1982=100. The base year has been changed from 2001.
Economics 13
Table 3.2: Reference index

Year Reference index
1960 100 (base)
1976 296
1982 490 100 (new base)
1998 405
2001 458 100 (new base)
2007 April 128
We have attempted the same exercise using the new base year of 2001
for CPI-IW (All India average consumer price index for industrial
workers).
Price index for 2001 by old base (1982=100) was 458. One needs to
divide given years price index by price index of the base years. For
example, Kuppuswamys price index for 1976 was based on 1960 as 100.
In other words means that any thing which cost Rs 100 in 1960 would
cost Rs 296 in 1976. The criteria were, however, changed in 1982 to 100
(called as new base). As per criteria of 1960 (old base), the price index
for 1982 was 490. Therefore, we get price index of 1976 converted to
new base:
Price index by old base for 1982 = 490
Price index by new base for 1982=100
Price index by old base for 1976 was 296.
Conversion factor for 1976 by new base was calculated as follows:
100/490 296 = 60.04.
To know the price increase in 1998, price index by then new base
(1982) was divided by conversion factor. Mishra, thus determined new
income criteria for 1998 by multiplying old income ranges of 1976 by
6.745 (obtained by dividing price index of 1998 by 60.04 (405/60.04=6.745)
on the basis of base year of 1982.
Now in view of new base for 2001 updating for current year is
attempted hereby to help researchers in formulating their ranges of
income for upcoming research. Conversion factor for 1982 base year has
changed with considering 2001 as base year. To get updated conversion
factor same exercise is adopted as follows:
Price index by old base for 2001=458
Price index by base for 2001 =100
Price index by old base for 1998 was 405
Price index by new base for 1998=100/458 405=88.42
To calculate conversion factor for the year 2007, we have to divide
price index by 88.428. All-India average consumer price index numbers
for industrial workers (Base 2001=100) shows general index as 128 on
April 2007.
A conversion factor can be obtained by calculating from 1976 index
also, and it comes as 9.764, which implies 9.764 times price increased as
compared to 1976. Multiplying 1976 income by the factor of 9.764 would
also provide scale for 2007.
Now the prices from 1982 levels have increased, and that increase can
be obtained by multiplying prices of that time by the factor obtained as
follows: 128/88.428 = 1.45.
Revised table (Table 3.3) for scales in 2007 to define socioeconomic
status has thus obtained as follows (by multiplying 1998 income ranges
by the factor 1.45): This revised prices scale for different socioeconomic
status has shortcomings as educational and occupational factors also
need to be revised by large scale survey. Another lacuna is also the
2
same as were in modification for the year 1998. However, this exercise
will provide some clue for setting income group in researches as per
current inflation rate.
Table 3.3: Kuppuswamys socioeconomic status scale

A. Education score
1. Profession or Honours 7
2. Graduate or postgraduate 6
3. Intermediate or post high school diploma 5
4. High school certificate 4
5. Middle school certificate 3
6. Primary school certificate 2
7. Illiterate 1
B. Occupation score
1. Profession 10
2. Semi-profession 6
3. Clerical, Shop-owner, Farmer 5
4. Skilled worker 4
5. Semi-skilled worker 3
6. Unskilled worker 2
7. Unemployed 1
C. Family income per Score Modified Modified
month (in Rs) original for 1982 for 2007
1. 2000 12 13500 19575
2. 1000-1999 10 6750-13499 9788-19574
3. 750-999 6 5050-6749 7323-9787
4. 500-749 4 3375-5049 4894-7322
5. 300-499 3 2025-3374 2936-4893
6. 101-299 2 676-2024 980-2935
7. 100 1 675 979
Total score Socioeconomic class
26-29 Upper (I)
16-25 Upper middle (II)
11-15 Middle lower middle (III)
5-10 Lower upper lower (IV)
<5 Lower (V)
Economics 15
REFERENCES
1. Kuppuswamy B. Manual of socioeconomic status (Urban), Manasayan,
Delhi, 1981.
2. Mishra D, Singh HP. Kuppuswamys socioeconomic status scale a
revision. Indian J Pediatr 2003;70(3):273-74.
3. Kumar P. Indian Journal of Community Medicine 1993;18:2.
Chapter
4 Communicable Diseases
CHAPTER OUTLINE
COMMUNICABLE DISEASE TUBERCULOSIS
PEDIATRIC TUBERCULOSIS LEPROSY
LEPROSY CONTROL FILARIASIS
DIARRHEA AND DYSENTERY CHOLERA
SCABIES SEXUALLY TRANSMITTED DISEASES
COMMUNICABLE DISEASE
Definition
An illness due to a specific infectious agent or its toxic products capable
of being directly or indirectly transmitted from man to man, animal to
animal or from the environment (through air, dust, soil, water, food, etc.)
to man or animal.
Definition of Infection
The entry and development or multiplication of an infectious agent in the
body of man and animals.
Infectious disease: A clinically manifest disease of man or animal resulting
from an infection.
Contamination: The presence of an infectious agent on a body surface; also
on or in clothes, beddings, toys, surgical instruments or dressings or other
inanimate articles.
Contagious disease: A disease that is transmitted through contact, e.g. scabies
trachoma infestation.
Containment: The concept of regional eradication of communicable disease.
Infestation: For persons or animals the lodgment, development and
reproduction of arthropods on the surface of the body or in the clothing,
e.g. lice, itchmite.
Host: A person or other animal including birds and arthropods that affords
subsistence or lodgment to an infectious agent under natural condition.
1. Obligate host Means the only host
2. Definitive host Parasite passes its sexual stage in host
3. Intermediate host Parasite passes its a sexual stage in host
4. Transport host (carrier) Organism remains alive but do not
undergo development
Case
Case is defined as a person in the population or study group identified
as having the particular disease, health disorder or condition under
investigation.
Primary case: Refers to the first case of communicable disease introduced
into the population unit being studied.
Index case: Refers to the first case to come to the attention of the investigator.
Secondary case: Secondary case are those developing from contact with
primary case.
Epidemic (Epiupon, demospeople)

The unusual occurrence in a community or region, of disease, specific
health-related behavior (e.g. smoking) or other health related events
(e.g. traffic accidents) clearly in excess of expected occurrence.
Endemic (Enin, demospeople)

It refers to the constant presence of a disease or infectious agent within a
given geographic area or population group, without importation from
outside may also refer to the usual or expected frequency of the disease
within such area or population group.
Sporadic
The cases are so few and separated widely in space and time that they
show little or no connection with each other, nor a recognizable common
source of infection, e.g. polio, tetanus.
Pandemic
An epidemic usually affecting a large proportion of the population
occuring over a wide geographic area such as a section of a nation, the
entire nation, a continent or the world, e.g. influenza pandemics of 1918
and 1957.
Disease
Disease is a condition of the body or some part or organ of the body in
which its functions are disrupted or deranged; in simple terms it is the
physiological or psychological dysfunction.
Illness
Illness is a subjective state of the person who feels aware of not being
well.
Sickness
Sickness is a state of social dysfunction, i.e. a role that the individual
assumes when ill. It is quite difficult to assess the illness and sickness,
however, disease can be measured directly or indirectly in terms of clinical

state, disability, and death.
TUBERCULOSIS
It is a chronic bacterial infectious disease caused by Mycobacterium
tuberculosis and is characterized by formation of granuloma in infected
tissue and by cell-mediated hypersensitivity (Table 4.1). Dr Robert Koch
discovered TB bacillus on 24th March 1882.
Sites Affected
Lungs, intestine, meninges, bones, lymph nodes and skin.
It has been reported as one of most important public health problem by
all regions of WHO.
It affects the cream of population, i.e. adults in age group of 21 to 40
years.
Table 4.1: Important rates in relation to burden of tuberculosis
Prevalence of TB infection 30%
Incidence of TB infection (ARI) 1.4% in 0-4 years, 2.1% in 0-14
years, 1.7% is average ARI
Incidence of active TB 168/100,000/year
Incidence of sputum positive 075/100,000/year
Prevalence of sputum positive 0.4%
Primary drug resistance 3-13.3%
Primary resistance to INH 10.6-21.83%
Primary resistance to rifampicin 0-11.9%
Acquired resistance to INH 34.5%-76%
Acquired resistance to rifampicin 0.53.26%
Ethmbutol resistance 0-20.6%(0.5%)
Streptomycin resistance 0/35.8%(2.4%)
Any one drug resistance (means 10.7%)
Multidrug resistant TB 3.5-42.3%
Resistance to 4 drugs 0%-14.1%
In new cases (mean 1.0%)
(Source: Paramasivan, 1998, Jain, et al. 1992, Pablos-Mendez, et al. 1998, Espinal, et al. 2001,
2004; Negi, et al. 2003; WHO Report 2005).
Economic Burden of Tuberculosis

1. TB kills more people in India than HIV, STD, malaria, leprosy and
tropical diseases combined.
2. Every year 30,000 children are forced to leave school because their
parents have tuberculosis, and 1,00,000 women lose their status as
mothers and wives because of social stigma.
3. Every year, more than 17 crores more days are lost to the National
Economy on account of tuberculosis at a cost of Rs 700 crore.
Epidemiological Indices
1. Prevalence of infection
2. Prevalence of disease or case rate
3. Incidence of infection
4. Incidence of new cases
5. Prevalence of suspected cases
6. Prevalence of drug resistance cases
7. Mortality rate.
Epidemiology
Agent: Mycobacterium tuberculosis which is commonly known as Koch
bacillus or tubercle bacilli or acid fast bacillus (AFB).
Sources
1. Human:
a. Rapid multiplier
b. Slow multiplier
2. BovineInfected milk
3. Atypical Mycobacterium.
Communicability
Patients are infective as long as they remain untreated.
Host Factors
Age: Prevalence increases with age up to the age of 45 to 54 in males.
Sex: In female the peak of tuberculosis prevalence is below 35 years.
One percent prevalence: In under 5 years of age.
Thirty percent prevalence: At the age of 15 years.
Common in elderly.
Environmental Factors
Housing factors
1. Darkness
2. Illventilated
3. Overcrowded.
Social factors
1. Poor quality of life
2. Poor housing
3. Overcrowding.
4. Population explosion
5. Under nutrition
6. Lack of education
7. Large families
8. Early marriages
9. Lack of awareness regarding cause of illness
10. Poor sanitation
11. Air pollution
12. Spitting indiscriminately
13. Sharing of Hukka and smoke
14. Purdha system.
Incubation period: Three to six weeks
Mode of transmissions
1. Inhalation
2. Ingestion
3. Surface implantation.
Case Finding
Based on four cardinal symptoms:
1. Continuous, irregular, intermittent and low grade fever for more than
two weeks
2. Cough with expectoration for more than two weeks
3. Chest pain (plural involvement)
4. Hemoptysis.
Definitions
(According to WHO)
Case: Patient whose sputum is positive for tubercular bacilli.
Suspected case: Patient whose sputum is negative for tubercular bacilli and
X-ray suggestive of shadow.
Case Finding Tools (Table 4.2 to 4.7)

1. Sputum examination.
2. Mass miniature radiography (MMR)
3. Tuberculin test.
4. Other tests:
a. Polymarase chain reaction (PCR)
b. CT scan
c. Magnetic resonance imaging (MRI).
Sputum Examination
Two samples are to be collected:
1. Over night sputum
2. Spot sputum.
Chemoprophylaxis
Primary
When drug is given to person not infected so far (Tuberculin negative)
and who has been exposed to open case.
Secondary
INH is given to person already infected (Tuberculin positive) in order to
prevent development of disease.
Treatment
Drug Regimens Currently used in India

Standard regimens/Conventional regimens (Table 4.2)
Short-course chemotherapy regimens (Table 4.3).
Conventional Regimens
Two types:
1. Daily regimens
2. Bi-weekly regimens.
Table 4.2: Standard regimens/conventional regimens

Regimen Regimen with drugs and Duration Mode and rhythm Instructions
code dosage (Months) of administration
2 STH/10TH Inj. S (IM) adminis- Inj. adminis-
a. Intensive phase tered daily. Other tered DTC/
(2 months) two drugs orally PHI/other
S = 0.75 g daily in a single health
H = 300 mg dose, self-adminis- facilities
R1 T = 150 mg 12 tered at home Oral drugs
b. Continuation phase issued on
(10 months) monthly
H = 300 mg basis by
T = 150 mg DTC/PHI
R2 12TH 12 Both drugs orally Issued on
H = 300 mg daily at home in monthly
T = 150 mg a single dose basis by
DTC/PHI
Table 4.3: Short-course chemotherapy regimens (SCC)

Regimen Regimen with drugs and Duration Mode and rhythm Instructions
code dosage (Months) of administration
2 EHRZ/6TH
a. Intensive phase All drugs daily at Issued on
(2 months) the same time, self- fortnightly
E = 800 mg, H = 300 mg administered at home basis
R = 450 mg, Z = 1.5 gm 8 Both drugs orally Issued on
RA b. Continuation phase daily, self-adminis- monthly
(6 months) tered at home basis by
H = 300 mg, T = 150 mg DTC/PHI
RB 2 SHRZ/4 S2H2R2
a. Intensive phase (2 months) Inj. S (IM) admini- All drugs
nistered daily. Other adminis-
S = 0.75g, H = 300 mg 3 drugs orally daily tered under
in a single dose, supervision
R = 450 mg, Z = 1.5 g 6 under supervision at DTC/PHI
Twice weekly; all
b. Continuation phase drugs together All drugs
(4 months) administered
S = 0.75 g, H = 600 mg under
R = 600 mg supervision
at DTC/PHI
S = Streptomycin, R = Rifampicin, T = Thioacetazone, H = Isoniazid
Z = Pyrazinamide, E = Ethambutol
Table 4.4: Category of patients for treatment

Regimen code Category
R1 a. Smear negative patients with extensive radiological evidence of disease/
cavity/toxemia
b. New smear positive cases where SCC is not available or a patient is
unable to continue SCC
c. Extra- pulmonary patients in general (e.g. tubercular lymphadenitis)
d. Cases, sputum positive after treatment completion with RA who are unable
to attend DTC or other specialized centers on referral for further treatment
R2 a. Smear negative patients with X-ray evidence of tuberculosis other than
those in (R1 a)
b. Lost patients, smear negative on reporting back, irrespective of previous
history of treatment
c. Highly irregular patients (e.g. with cumulative default of more than a month
in the intensive phase of any of the regimens or in continuation phase of
RB) irrespective of the smear result
RA New cases
a. All smear positive cases newly indexed under DTP, irrespective of age
and previous treatment outside the program
b. Serious forms of extrapulmonary tuberculosis (e.g. meningeal, spinal)
RB Retreatment cases
a. Patients remaining smear positive on completion of treatment with R1,
R2 and RA or on return after lost
b. Cured patients returning with smear positive result
Note: Patients requiring retreatment should be referred to DTC for initiation of treatment and sent
back to the concerned PHIs for continuation of prescribed regimen.
Table 4.5: Doses of antitubercular drugs for adult and children

Medication Adult Children
Dose thrice Number of pills Daily dose Thrice a
a week in combipack week
Isoniazid 600 mg 2 5 mg/kg 10-15 mg/kg
Rifampicin 450 mg* 1 10 mg/kg 10 mg/kg
Pyrazinamide 1500 mg 3 25 mg/kg 35 mg/kg
Streptomycin** 0.75 mg 15 mg/kg 15 mg/kg
Ethambutol# 1200 mg 3 15 mg/kg 30 mg/kg
* Patient who weigh 60 kg or more are given an extra 150 mg dose.
** Patient over 50 years of age are given 0.5 gm of streptomycin.
# Ethambutol should not be given in children below 6 years of age.
Table 4.6: Important regimens in relation to burden of tuberculosis

Adult Children
Medication Drug action Daily Dose No.of Daily Thrice a
dose thrice pills in dose week
regimen a week combipack
Isoniazid Bactericidal 300 mg 600 mg 2 5 mg/Kg 10-15 mg/Kg
Rifampicin Bactericidal 450-600 mg 450 mg* 1 10 mg/Kg 10 mg/Kg
Pyrazinamide Bactericidal 1-1.5 gm 1.5 gm 2-3 25 mg/Kg 35 mg/Kg
Streptomycin** Bactericidal 0.75-0.5 gm 0.75 gm 15 mg/Kg 15 mg?Kg
Ethambutol# Bacteriostatic 800 mg 1200 mg 2-3 2.5 mg/Kg 30 mg/Kg
Thiacetazone Bacteriostatic 150 mg Not applied Not applied
Ofloxacine/Cipro Bactericidal 200/400 mg
Kanamycine Bactericidal 1gm
Ethionamide Bactericidal 250-1 gm
Cycloserine Bacteriostatic 250 mg
* Patient who weigh 60 kg. or more are given an extra 150 mg. dose
** Patient over 50 years of age are given 0.5 gm of streptomycin
# Ethambutol should not be given in children below 6 years of age
Important Definitions
Smear +ve TB
At least 2 initial sputum smear +ve for AFB or 1AFB +ve smear and 1+ve
culture.
Smear ve TB
At least 3 ve smears, but tuberculosis suggestive symptoms and X-ray.
Abnormalities or +ve culture (Fig. 4.1).
Adherence
Persons take appropriate drug regimen for required time (also known as
compliance).
New Cases
A Patient with sputum +ve pulmonary tuberculosis who have never had
treatment for TB or has taken anti-TB drugs for less than four weeks.
Table 4.7: Classification of categories, types of patients,

regimens adopted under RNTCP
Category Type of patient Regimens in months Duration Color of

the box
Category New sputum smear 2(HRZE)3@4(HR)3 6 Red
I Positive seriously ill
sputum negative
Seriously ill extra-
pulmonary**
Category Sputum positive 2(HRZES)3 1(HRZE)3# 8 Blue
II relapse*** 5(HRE)3
Sputum positive
failure***
Sputum positive
treatment after
default
Category Sputum negative 2(HRZ)3 4(HR)3 6 Green
III extrapulmonary
not seriously ill
Category MDR-TB cases# # [6(9)Km Ofx eto Cs 24-27
IV ZE/18 Ofx eto Cs E]
All the drugs are administered thrice weekly. The number before the letters refers to the
number of months of treatment. The abbreviations are as follow: R-Rifampicin,
E-Ethambutol, H-INH, S-Streptomycin, and Z-Pyrazinamide, K-Kanamycin, O-Oflaxacin,
Et-Ethionamide, C-Cycloserine.
**Examples of seriously ill extrapulmonary TB cases are meningitis, disseminated TB,
TB pericarditis,Tuberculous peritonitis, bilateral or extensive pleurisy, spinal involvement
with neurological complications; smear negative pulmonary TB with extensive parenchymal
involvement and intestinal and genitourinary TB.
If sputum smear is positive after two months of the start of treatment then same treatment
regimen (Intensive phase) should be continued for another one month. Thereafter
continuation phase should be started irrespective of sputum report at three months. If patient
is sputum positive at five months also then he/she should be labeled as failure and category
II treatment should be started from the beginning.
***In rare and exceptional cases, patients who are sputum smear-negative or who have
extrapulmonary disease can have relapse or failure. This diagnosis in all such cases should
always be made by a medical officer and should be supported by culture or histological
evidence of current active tuberculosis. In these cases, the patient should be categorized
other and given category II treatment.
# If the Sputum smear is positive even after three months of the start of treatment in category
II patients then four drugs (HRZE), excluding streptomycin, should be extended for one
more month.
# # Smear examination should be conducted monthly during intensive phase and at least
quarterly during continuous phase. Culture examination should be done at least at 4,6,12,18
and 24 months of treatment.
Fig. 4.1: Diagnosis of tuberculosis
Relapse
A patient who returns smear +ve having previously been treated for TB
and declared cured after the completion of his treatment.
PEDIATRIC TUBERCULOSIS
Tuberculosis is a major cause of childhood morbidity and mortality. It is
estimated that about six to eight percent of all new TB cases are in the
pediatric age group and majority is in one to four years. Childhood TB is
a reflection of the prevalence of sputum positive pulmonary tuberculosis
in the community and the extent of transmission of infection in the
community. Children suffer from severe forms of TB because of their poor
immunity.
Pediatrics DOTS
Weight Box color Regimen
11-17 kg 1 Orange 2(HRZE)34 (HR)3
6-10 kg 1 Yellow 2(HRZE)34 (HR)3
18-25 kg 1 Orange + 1 Yellow 2(HRZE)34 (HR)3
26-30 kg 2 Orange 2(HRZE)34 (HR)3
Orange box Yellow
24 strips 24 strips
H = 150 mg H = 75 mg
R = 150 mg R = 75 mg
Z = 500 mg Z = 250 mg
E = 400 mg E = 200 mg
18 strips
H = 150 mg H = 75 mg
R = 150 mg R = 75
Pediatric TB do not accord high priority as it is less infectious. But because

of serious forms of TB that occurs in children they are more likely to die if
not treated properly.
Failure Case
A patient who was initially smear +ve , who began treatment and who
remained or became smear +ve again at five months or later during the
course of treatment.
Return after Default
A patient who returns sputum smear +ve, after having left treatment for
at least two months.
Transfer In
A patient recorded in another administrative area register and transferred
into another area to continue the treatment.
Transfer Out
A patient who has been transferred to another area register.
Cured
Initially smear +ve patient who completed treatment and had ve smear
result on at least two occasions (one at treatment completion).
Treatment Completed
Initially smear ve patient who received full course of treatment, or smear
+ve who completed treatment with ve smear at the end of initial phase,
but no or only one ve smear during continuation phase and none at the
end of the treatment.
Died
Patient who died during treatment regardless of cause.
Directly Observed Therapy Short-course (DOTS)

1993DOT Pilots
1998DOTS scale-up begins
2000More than 30 percent of country covered by DOTS.
Principles
1. Case detection primarily by microscopic examination of sputum of
patient presenting to health facilities.
2. Adequate drug supply.
3. Short-course chemotherapy given under direct observation.
4. Systematic monitoring and accountability for every patient diagnosed.
5. Political will.
Follow-up
Response to treatment
Symptomatic and general well being usually within 10 to 15 days.
Fever subsides by two weeks , occasionally may take up to one month
Respiratory symptoms decrease by second month and may subside by
third or fourth month.
Sputum Examination
In category I and IIIRepeat sputum smear examination at the end of
2nd, 4th , and 6th month (Flow chart 4.1).
Flow chart 4.1: CategoryI and III
In category IIRepeat sputum smear examination at the end of 3rd,

5th and 8th month (Flow chart 4.2).
Flow chart 4.2: CategoryII
Structure of the RNTCP
National Level (Deputy Director GeneralTB)

National Institutes
(NTI Bangalore, TRC Madras)
State Level (State Tuberculosis Officer)

State TB Training and Demonstration Center (Director)
District Level (District Tuberculosis Officer)

Sub-district Level (Tuberculosis Unit)
Medical officerTB control (MOTC)
Senior treatment supervisor (STS)
Senior TB laboratory supervisor (STLS).
Peripheral Health Level

Microscopy centers
Treatment centers
DOTs Providers.
Difference in National Tuberculosis Program and

Revised NTCP (Table 4.8)
Table 4.8: Difference in National Tuberculosis Program and Revised NTCP

NTP RNTCP
Objective Early diagnosis and treatment Breaking the chain of transmission
Operational 1. Not defined 1. Cure rate 85%
2. Case finding 70% of estimated cases
Strategy 1. Short-course chemotherapy 1. DOTs (Directly observed
(SCC) unsupervised treatment short-course)
2. Conventional 2. Uninterrupted drug supply
Diagnosis 1. More emphasis on X-ray 1. Mainly sputum microscopy
2. Two sputum smears 2. Three sputum smears
3. One sputum +ve is 3. One +ve is not a case
considered a case
Reasons for Dropout of the Treatment

1. Long distance from PHI/DTC
2. Transport facilities to PHI/DTC
3. Costing time
4. Affordability (economic status for travelling)
5. Unpleasant side effects
6. Uncooperative staff
7. Communication gap
8. Personal inconvenience
9. Discontinuous/improper treatment
10. Demoralization
11. Stigma
12. Ignorance
13. Sex bias
14. Views expressed by doctor, uncooperative staff, shortage of staff,
shortage of drug
15. Interest in hospital admission
16. Belief in other systems of medicines.
National TB Control Program

Program has been in operation since 1962 in India.
Its objectives are:
1. Long-term
2. Short-term.
Objectives of NTCP (1962)
Long-term Objectives
To reduce tuberculosis in the community to that level when it ceases to be
a public health problem, i.e.
a. One case infects less than one new person annually.
b. The prevalence of infection in age group below 14 years is brought
down to less than 1 percent, against about 30 percent, as at present.
Short-term Objectives
a. To detect maximum number of TB cases among the outpatient attending
any health institution with symptoms suggestive of TB and treat them
effectively.
b. To vaccinate newborns and infants with BCG.
c. To undertake the above objectives in an integrated manner through all
the existing health institutions in the country.
Disinfection of Sputum
1. Cheap handkerchiefs, cotton tissue towels and paper box, etc. used to
receive the sputum and nasal discharge of the patient, should be burnt.
2. Sputum cups containing 50 percent carbolic lotion.
3. Disposal of sputum should be done by burying.
4. Safe, cheap and practical method is to receive sputum in small tin can
and put boiling water in it, within a minute bacilli will be killed.
5. Cups and utensils should be disinfected by boiling.
6. Beds and beddings should be exposed to sunlight.
7. Wet mopping of floors.
8. Fly sitting on sputum and other discharges should be prevented.
DOTS-Plus Strategy
DOTS-Plus for MDR-TB is a comprehensive management initiative under
development that is built upon the five elements of the DOTS strategy
DOTS-Plus takes into account specific issues, such as the use of second-
line anti-TB drugs, that need to be addressed in areas where there are
significant levels of MDR-TB. The goal of DOTS-Plus is to prevent the
further development and spread of MDR-TB. DOTS-Plus is not intended
as a universal option and is not required in all settings. DOTS-Plus should
be implemented in selected areas in order to combat an emerging epidemic.
The underlying principle is that proper implementation of DOTS will
prevent the emergence of drug resistance and should be the first step in
fighting MDR-TB. It is not possible to conduct DOTS-Plus in an area
without having an effective DOTS-based TB control program in place.
The Working Group has identified access to second-line anti-TB drugs as
one of the major obstacles to the implementation of DOTS Plus pilot
projects. While access to second-line anti-TB drugs must increase, these
drugs should only be used in DOTS-Plus pilot projects that meet the
standards set forth by the Scientific Panel of the Working Group in the
Guidelines for the Establishment of DOTS-Plus Pilot Projects for the Management
of MDR-TB (the Guidelines). Adherence to the Guidelines results in proper
management of existing cases of MDR-TB while preventing the rapid
development of resistance to second-line anti-TB drugs. The Guidelines
are based on the recommendations of the Scientific Panel of the Working
Group and will be further developed based on evidence provided by
DOTS-Plus pilot projects. In addition to explaining the DOTS-Plus concept,
the Guidelines define the minimum requirements necessary to establish
and maintain DOTS-Plus pilot projects. Sample protocols are available to
design standardized or individualized treatment regimens with second-
line anti-TB drugs to be used in DOTS-Plus pilot projects.
Components
DOTS-Plus refers to DOTS programs that add components for MDR-TB
diagnosis, management and treatment. The DOTS-Plus strategy promotes
full integration of DOTS and DOTS-Plus activities under the RNTCP, so
that patients with MDR- TB are both correctly identified properly managed
DOTS Plus is having five components:
1. Sustained government commitment.
2. Accurate, timely diagnosis through quality assured culture and drug
susceptibility assured culture and drug susceptibility testing (DST).
3. Appropriate treatment utilizing second-line drugs under strict
supervision.
4. Uninterrupted supply of quality assured anti-TB drugs: and
5. Standardized recoding and reporting system.
Strategy and Focus

1. DOTS reveals the emergence of drug-resistant TB and MDR-TB by
ensuring that patient to the full course of treatment.
2. DOTS-Plus is designed to cure MDR-TB using second line anti-TB
drugs.
3. DOTS-Plus is needed in areas where MDR-TB has emerged due to
previous inadequate programs.
4. DOTS-Plus pilot project are only recommended in setting where the
DOTS strategy place to protect against the creation of further drug
resistance.
5. It is vital that DOTS-Plus pilot project are implemented following the
recommendation. Stop TB working group on MDR-TB in order to
minimize the risk of creating resistant second line anti-TB drugs.
6. Before launching DOTS-Plus pilot project, WHO member states are
strongly recommended to consult WHO.
7. With the coordination of the working group on DOTS-Plus for

MDR-TB and a partnership industry, the price of second line anti-TB
drugs have fallen considerable, making these more accessible to the
poor.
Green Light Committee Initiative

Component two of the stop TB strategy calls for the control and prevention
of multidrug-resistant tuberculosis (MDR-TB) through: (i) increased access
to quality-assured second-line anti-TB drugs; and (ii) prevention of
development of resistance to anti-TB drugs.
The Green Light Committee (GLC) initiative, together with the working
group on MDR-TB, promotes implementation of this strategy in
accordance with the global plan to stop TB (20062015) and the global
MDR/XDR-TB response plan (20072008).
Established in 2000, the GLC initiative is the mechanism that enables
access to affordable, high-quality, second-line anti-TB drugs for the
treatment of MDR-TB. Its objectives are:
Ensuring effective treatment of patients with MDR-TB in accordance
with guidelines published by the World Health Organization (WHO)
on the programmatic management of MDR-TB;
Increasing access to technical assistance to facilitate rapid scale-up of
MDR-TB management;
Increasing access to high-quality, low-cost, second-line anti-TB drugs
for the treatment of MDR-TB among well-performing programs;
preventing the development of resistance to second-line anti-TB drugs
by ensuring rational drug use;
Advising WHO on policy-related matters to effectively prevent and
control MDR-TB based on the best available scientific evidence.
The GLC initiative therefore contributes to reducing transmission of
TB, preventing further drug resistance and ultimately reducing the global
burden of TB. The initiative is coordinated by the GLC Secretariat, which
is hosted and administered by WHO. The Global Drug Facility (GDF), an
arm of the stop TB partnership, which is also hosted and administered by
WHO, carries out drug procurement for GLC-approved programs.
Technical assistance to MDR-TB program is coordinated and delivered
by WHO and its technical partners.
HIV Infection and Risk of Tuberculosis
HIV increases the susceptibility to infection with M. tuberculosis. In a person
infected with Mycobacterium tuberculosis, HIV is a potent cause of
progression of tuberculosis infection to disease. Compared to an individual
who is not infected with HIV, an individual infected with HIV has a 10
times increased risk of developing tuberculosis.
As HIV infection progresses, CD4 lymphocytes decline in number and

function. The immune system is less able to prevent the growth and local
spread of M.tuberculosis. The duration of TB in HIV infected persons is
more difficult on account of more non-TB respiratory diseases, more smear
negative, disseminated and extrapulmonary TB and X-rays being less
specific. Fortunately more than 90 percent of surviving HIV infected TB
can be cured provided complete treatment is taken regularly.
LEPROSY
Leprosy continues to be a social and public health problem but the situation
is gradually improving.
History
Milestones
1955 National Leprosy Control Program
1983 National Leprosy Eradication Program (MDT started)
1991 World Health Assembly resolution to eradicate leprosy
by 2000 AD
1993 World Bank supported the MDT program Phase I
1997 Mid-term appraisal
1997-2002 Ninth Five Years Plan
2000 NLEP Project Phase II
It is a disease of antiquity. The causative organism, Mycobacterium
lepreae was discovered in 1873 by Hanson Norway.
Sulphon drugs were introduced for treatment of leprosy in 1943.
Burden of Leprosy
World
There are around 1.3 million cases of leprosy in the world (1996). Leprosy
remains a public health problem in 55 countries, but 16 countries account
for 91 percent of the total number of registered cases and five of them
(Brazil, India, Indonesia, Myanmar, and Nigeria) account for about
82 percent. Globally 60 percent of the estimated cases are contributed by
India.
India
Prevalence rate (PR) is 3.74/10,000 population (March 2001) which was
57/10,000 in 1981.
Elimination level (<1/10,000) achieved in 13 statesNagaland,
Haryana, Punjab, Mizoram,Tripura, Himachal Pradesh, Meghalaya,
Sikkim, Jammu and Kashmir, Rajasthan, Manipur, Assam, and Kerala.
States close to achieve eliminationGujarat, Arunachal Pradesh,
Daman and Diu.
Leprosy is endemic mainly in states of Bihar, Jharkhand, Chhattisgarh,

UP, West Bengal, Orissa and MP where 64 percent are found.
Bihar has 24 percent of recorded leprosy cases in India.
A total of 5.59 lakh cases were detected in India by 2000-2001 due to
intensification of the program, the highest number of cases detected in
any year.
Annual new cases detected were 4 to 7.8 lakh. Out of the total
18.5 percent were children.
Deformity cases (Grade II and above) among new cases were
2.7 percent.
MB cases among new cases were 34 percent.
Essential Indicators for Leprosy

An indicator is a calculation, which is used to measure different aspects
of leprosy control. Indicators can give different information:
a. They can tell how big or how serious is the problem of leprosy in the
area. It can help one to analyze the situation regarding leprosy in the area.
b. They can help to assess how well the leprosy control program is
functioning. This will help to plan and run program more efficiently.
The following indicators are mainly used.
Prevalence Rate (Point Prevalence Rate)

Prevalence indicates the quantum of morbidity due to leprosy in the
community. Prevalence rate is calculated by using the following formula.
No. of Regd cases in the project are at a point of time

PR = 10,000
Estimated mid-year population
A reduction in prevalence rate from year to year indicates a favorable

impact of the measures taken.
New Case Detection Rate

NCDR or annual case detection rate ACDR. It is calculated as follows:
No. of new cases detected in the new year

NCDR = 10,000
Mid-year population
New case detection roughly indicates the quantum of transmission.

A reduction in new case detection rate indicates a reduction in transmission.
Disability Rate Among New Detection

It can be calculated as follows:
No. of new cases having disability grade '2'
= No. of new cases detected during the year 100
It indicates the efficiency in early detection of cases.
Proportion of Children among New Detection

No. of children (0-14 year) cases among new cases
= 100
Total new cases detected during the year
Reduction of this rate in the later years indicates favorable impact on
disease transmission.
Multibacillary (MB) Rate

No. of MB cases among new cases
= 100
Total new cases detected during the year
Proportion of Single Skin Lesion (SSL) Case Rate

No. of SSL cases detected during the year
= 100
Total no. of new cases detected during the year
Cohort Cure Rate MB/PB

a. The No.of MB/PB cases put under treatment during the year.
b. The No.of those patients of the Cohort group who have completed full
course of treatment during the next one and half years.
b
Cohort cure rate = 100
a
Epidemiology
Agent (Mycobacterium leprae)

1. Sources of infection: Lepromatous and borderline lepromatous cases in
the family or among close contacts.
2. Mode of transmission:
a. Droplet infection
b. Contact transmission.
3. Period of communicability: Lepromatous and borderline cases become
noninfectious within two weeks of treatment with rifampicin or three
months of treatment with dapsone.
4. Incubation period: Long, usually three to five years, shorter incubation

in tuberculoid leprosy.
5. Secondary attack rate: Five to twelve percent.
Host
1. Age: Occurs at all ages, with maximum incidence during 10 to 20 years
2. Sex: More in males, M:F is 3:2 in all types of leprosy and 3:1 in
lepromatous type of leprosy.
Environmental and Social Factors

1. Physical environment
2. Social environment
3. Biological environment.
Physical environment: The factors are:
a. Large family size
b. Over crowding
c. Poor ventilation
d. Urban slum.
M. leprae can remain viable in dried nasal secretions for 9 days and in
moist soil for 46 days.
Social environment: Deep rooted prejudices lead to social ostracism of
patients with leprosy, Thus, there is delay in seeking treatment, thereby
increasing the possibility of transmission.
Biological environment: Wild armadillos in limited area of USA have been
found to be infected.
a. Genetic factor-HLA linked gene
b. Migration
Mode of Transmission
1. Droplet infection
2. Contact transmission
3. Other routes
a. Breast milk
b. Insect vector
c. Tattooing needles.
Clinical Features
Presentation depends upon cell mediated immunity of the patient
(Tables 4.9 and 4.10).
Table 4.9: Classification of leprosy

NLEP Ridely and Jopling Indian International (Madrid)
Paucibacillary Indeterminate Indeterminate Indeterminate
TT Tuberculoid Tuberculoid
BT Pure neuritic
Multibacillary BB Borderline Borderline
BL Lepromatous
LL Lepromatous Lepromatous
Table 4.10: Immunological status and type of leprosy

Immunological status Type of disease
1. Poor immunity Lepromatous (LL) leprosy
2. Intermediate immunity Borderline leprosy (BB, BL, BT)
3. Good immunity Tuberculoid (TT) leprosy
Lepromatous Leprosy
Early manifestations commonly missed by patients include:
1. Nasal symptoms:
a. Stuffiness
b. Crust formation
c. Blood stained discharged from nose.
2. Edema of legs and ankles:
a. Bilateral and symmetrical
b. More marked in the evening.
Other overt manifestations include:
1. Skin lesions:
a. Macules (more common, papules and nodules.
b. Bilateral symmetrical and large.
c. Sites: Face, arms, buttocks, legs and trunk.
d. Hypopigmented.
2. Leonine facies:
a. Thickening of skin of forehead, causes deepening of the natural lines.
b. Ear lobes are thickened.
c. Eyebrows are lost (madarosis).
d. Nasal bridge may collapse.
3. Superficial nerves:
a. Thickened
b. Glove and stocking anesthesia.
4. Testicular atrophy leading to:
a. Sterility
b. Impotence
c. Gynecomastia.
5. Bone:
a. Periostitis
b. Disuse osteoporosis.
6. Eye:
a. Superficial punctate keratitis.
Diagnosis
1. Clinical examination
2. Bacteriological examination
3. Foot-pad culture
4. Histamine test
5. Biopsy
6. Immunological tests.
Clinical Examination
Diagnosis is fairly easy in lepromatous and non-lepromatous cases if the
disease is just kept in mind. Simple diagnostic guidelines have been
outlined by WHO. Difficulty may arise in the indeterminate type. It should
be confirmed by bacteriological examination of the material obtained by
the routine slit-and-scrape method from the edge of the lesion or from
the lobule of the ear. Nasal smear may also be used. Skin and nerve biopsy
may be performed in non-lepromatous cases.
Early detection of subclinical cases is obviously of great importance in
control of leprosy.
The following three are helpful in this:
i. Enlargement of great auricular nerve.
ii. Search for AFB in ear lobes of contacts of leprosy patients.
iii. Immunological test aimed at assessing cell mediated or humoral
immunity. The most commonly used test for cell mediated
immunity is the lepromin test, using either the Mitsuda or
Dharmendra lepromin preparation. There is evidence that the tests
for humoral immunoresponse, such as FLA-ABS, may be much
more sensitive than lepromin test alone.
The government has brought out a simple guide for medical officers to
help them to diagnose and manage leprosy patients. Some practical
guidelines for diagnosis are given below.
What are the principles of skin examination? How does one examine the skin?
1. Choose a spot where good light is available.
2. As far as possible, choose a spot where there is privacy.
3. Always examine the whole skin from head to toe.
4. Use the same order of examination always so that you do not forget to
examine any part of the body.
5. Compare both sides of the body.
What should one look for in the skin?

The following features must be noted when examining a patch on the skin:
Site: This is useful for follow-up.
Number: The number of lesions indicates the severity of the disease.
This is useful for classification and follow-up.
Color: May be hypopigmented (lighter in color than the rest of the skin),
or erythematous (red). Lesions of leprosy are never depigmented.
Erythematous color can be used to identify disease activity or a
reactional state (Active lesions or those in reaction are often red).
Sensory loss: This is useful both for diagnosis and classification of leprosy.
Loss of sensation is a cardinal sign of leprosy.
Tenderness on gentle tapping: This is seen in reactional states.
Presence of infiltration: This term refers to skin which is thickened, shiny
and erythematous. All three features must be present in the same area.
This may be seen in severe forms of leprosy.
How should One Test for Sensation?

Remember the cardinal sign: Hypopigmented or reddish skin lesion(s) with
definite loss of sensation.
It is very important to pick up the skill of eliciting sensory loss in skin
patch.
You will need a ball point pen/pin, etc.
Explain to the person what you are going to do and demonstrate it.
Touch the skin with the pen/pin. Ask the person to count aloud each
time he feels the pen/pin. Alternatively, ask the individual to point to
the spot touched with his finger.
Repeat this procedure a few times until the patient is familiar and
comfortable with the procedure.
Now ask the patient to close his eyes and repeat over the area to be
tested. Alternatively, the person should be blindfolded or some barrier
should be used to prevent his or her from watching the procedure.
Remember
1. Do not keep asking the patient whether he feels the pen/pin or not.
You may get misleading results.
2. When testing for sensation, touch the skin lightly with the pen/pin. Do
not stroke.
3. Proceed from the normal skin to the abnormal.
4. Give only one stimulus at a time.
5. Vary the pace of testing.
What are the General Principles of Nerve Palpation?
Examination of nerves in all the patients is very important for prevention
of deformity. This involves two aspects:
Palpation of the nerves for thickening, tenderness and consistency.

Assessment of nerve function.
1. When palpating the nerves, you should look for three things:
Thickening, tenderness and consistency.
2. When palpating the nerve, the patient should be properly positioned.
The examiner should also be positioned correctly.
3. Always compare both sides to assess thickness and consistency.
4. Look at the patients face while palpating the nerve to elicit tender-
ness.
5. Always palpate across the course of the nerve.
6. Feel along the nerve as far as possible in both directions.
7. Palpate gently with the pulp of the finger, not the tip.
How should We assess Nerve Function?
Nerve function assessment includes both motor and sensory function, i.e.
Voluntary Muscle Test (VMT) and Sensory Test (ST). Both VMT and ST
should be done for:
a. All patients with nerve thickening.
b. All patients with multibacillary leprosy.
How is Voluntary Muscle Testing done?
Voluntary muscle testing is done by first checking the range of movement
to see whether movement is normal, reduced or absent due to paralysis.
If movement is normal, a test for resistance is then done (Fig. 4.2). Press
gently in the opposite direction while asking the patient to maintain
position, resisting pressure as strongly as possible. Then gradually press
more firmly and judge whether resistance is normal, reduced or absent.
Always compare the right side with the left. The grading of the result can
be done as follows:
S (Strong)Able to perform the movement against full resistance.
W (Weak)Able to perform the movement but not against full
resistance.
P (Paralysed)Not able to perform the movement at all.
Bacteriological Examination
Skin smear
Nasal smear
Nasal scraping.
Bacterial Index (BI)

Bacterial Index (BI) is the only objective way of monitoring the benefit of
treatment. The WHO grading of smears for BI is as follows:
Negative : No bacilli found in 100 fields
One plus (+) : One or less than one bacillus in each
microscopic field
Fig. 4.2: Diagram of the human body showing nerves commonly invoiced in leprosy
Two plus (+ +) : Bacilli found in all fields

Three plus (+ + +) : Many bacilli found in all fields
Add G to the entry if globi are present
Bacterial index is calculated by totalling the number of + given to each
smear and dividing this number by the smears collected. A minimum of
seven sites should be examined; smears from four skin lesions, one nasal
swab, and smears from both ear lobes, e.g.
Right ear +++
Left ear +++
Nasal smear +++
First skin lesion +++
Second skin lesion ++
Third skin lesion +++
Fourth skin lesion ++
19
Bacterial index (BI)= 7 sites of examination
In paucibacillary leprosy the bacterial index is less than two; in

multibacillary leprosy, it is greater than two.
Two other types of grading are also in use for reporting bacterial index,
e.g. Dharmendras scale and Ridleys scale.
Morphological Index (MI)

During the course of microscopic examination of smears, it is possible to
distinguish and count the number of solid staining organisms (organisms
that stain completely) and irregularly staining bacilli. The percentage of
solid staining bacilli in a stained smear is referred to as Morphological
Index (MI). The total of the MIs for all sites divided by the number of
sites gives the average MI for the body. The criteria for calling the bacilli
solid rods are:
a. Uniform staining of the entire organism
b. Parallel sides
c. Rounded ends
d. Length five times that of the width.
It has been widely believed that only solid-staining organisms are viable.
Recently, however, doubts have been raised about this notion.
Histamine Test (Table 4.11)

This is very reliable method of detecting at an early stage peripheral nerve
damage due to leprosy. The test is carried out by injecting 0.1 ml of 1:1000
histamine phosphate intradermally into the hypopigmented patches or
in areas of anesthesia.
Table 4.11: Histamine testresult and interpretation
Result Interpretation
Bright flare (triple response) Normal skin
Delayed and feeble flare Indeterminate
Flare absent (BB)
Tuberculoid (TT)
Sweat Test (Table 4.12)

This test is recommended when difficulty is experienced in the diagnosis,
as for example, indeterminate leprosy.
0.2 ml of 1:1000 solution of pilocarpine is injected intra-dermally. Paint
with iodine and dust with starch powder.
Table 4.12: Sweat testresult and interpretation
Result Interpretation
Blue discoloration Normal skin
No color Leprosy
Lepromin Test
It is used to classify the type of lesion.
0.1 ml of antigen is injected intradermally. The reaction is read at

48 hours and 21 days.
Early reaction (Fernadez reaction): An inflammatory response develops
within 24 to 48 hours and this tends to disappear after 3 to 4 days. It is
evidenced by redness and induration at the site of inoculation. If the
diameter of the red area is more than 10 mm at the end of 48 hours, the
test is considered positive. The early positive reaction indicates whether
or not a person has been previously sensitized by exposure to and infection
by the leprosy bacilli. The early reaction is induced by soluble constituents
of the leprosy bacilli. The reaction corresponds to Mantoux reaction in TB.
Late reaction (Mitsuda reaction): The test is read at 21 days. If there is a
nodule more than 5 mm in diameter at the site of inoculation, the reaction
is said to be positive. The late reaction is induced by the bacillary
component of the antigen. It indicates cell mediated immunity.
Value of the lepromin test: Lepromin test is not a diagnostic test. It evaluates
the immmune status of leprosy patients. It helps in classification of leprosy.
This test also helps in assessing the prognosis in cases of leprosy of all
types.
Utility of lepromin test: In classifying the types of leprosy (Table 4.13).
Table 4.13: Classifying the types of leprosy
Test Type of leprosy
+++ TT
++ BT
ve BB, BL, LL
Lepromin positive individuals either escape the clinical disease (the

majority) or develop paucibacillary disease.
Lepromin negative individuals are at a higher risk of developing
progressive multibacillary leprosy.
Deformities Occurring in Leprosy (Table 4.14)
Table 4.14: Deformities occurring in leprosy
Face Mask face, facies leonina, sagging face, lagophthalmos, loss
of eye-brows (superciliary madarosis) and eyelashes (ciliary
madarosis), corneal ulcers and opacities, perforated nose,
depressed nose, ear deformities, e.g. nodules on the ear
and elongated lobules
Hands Claw hand, wrist-drop, ulcers, absorption of digits, thumb-
web contracture, hollowing of the interosseous spaces and
swollen hand
Feet Plantar ulcers, foot-drop, inversion of the foot, clawing of the
toes, absorption of the toes, collapsed foot, swollen foot and
callosities
Other deformities Gynecomastia and perforation of the palate
Features of Lepra Reactions (Reversal Reaction) (Table 4.15)

Table 4.15: Features of lepra reactions (reversal reaction)
Features Type 1 (Reversal reaction) Type 2 (Erythema nodosum
leprosum reaction)
Skin Existing lesions suddenly become Red, painful, tender, subcutaneous
red, swollen warm, and tender. (deep) nodules (ENL) appear
New lesions may appear commonly on face and arms and
legs. They appear in groups and
subside within a few days
Nerves Lesions when subsiding may Nerves may be affected but not as
show scales on the surface. commonly as in type 1
Nerves close to the skin may
become enlarged, tender and
painful (neuritis) with loss of
nerve function
Other Not affected Other organs like eye, joints, bones,
organs testes, kidney may be affected
General Not common Fever, joint pains, fatigue symptoms
Clinical Difference between Reversal Reaction and Relapse (Table 4.16)

Table 4.16: Clinical difference between reversal reaction and relapse
Reversal reaction Relapse
Time Generally occurs during Usually occurs only when
interval chemotherapy or within chemotherapy has been
6 months of stopping treatment discontinued, after an interval of
usually more than 6 months
Onset Abrupt and sudden Slow and insidious
Old lesions Existing lesions become Lesions may show erythema and
edematous, erythematous infiltration, but no tenderness
or tender
New Several new lesions appear New lesions are few
lesions
Ulceration Lesions may ulcerate Ulceration does not occur
Nerve Multiple nerve involvement Nerve involvement may occur only
involve- common, painful and tender in a single nerve; usually no pain,
ment tenderness
General May have fever, joint pains, Not usually affected
condition malaise
Response Rapid Nil
to steroid
treatment
Treatment of Reversal Reaction

During reversal reaction (multidrug therapy) MDT should be contained
without interruption along with antireaction treatment.
Antileprosy Drugs and their Characteristics (Table 4.17)

Table 4.17: Antileprosy drugs and their characteristics
Drug Dose (mg) Bactericidal activity
Dapsone 100 +
Rifampicin 600 +++
Ethionamide 375 ++
Prothionamide 375 ++
Clofazimine 100 +
Patient Grouping for MDT (Table 4.18)

Table 4.18: Patient grouping for MDT
Group criteria PB single skin lesion PB (Paucibacillary) MB (Multibacillary)
(patch) PB-SSL leprosy leprosy
Skin lesions 1 skin lesions 2-5 lesions 6 and above
asymmetrically Symmetrically
distributed distributed
Nerve No nerve No nerve More than one
involvement involvement involvement/ nerve trunk
only one nerve trunk involvement
Skin smear Negative at all sites Negative at all sites Positive at all sites
Dosage Schedule for MDT (Table 4.19)

Table 4.19: Dosage schedule for MDT
Drugs used Dosage Frequency of Criteria for cure
(adults) administration
MB leprosy Rifampicin 600 mg Once monthly Completion of 12
Dapsone 100 mg Daily monthly. Pulses
Clofazimine 300 mg Once monthly within 18 months
50 mg Daily
PB leprosy Rifampicin 600 mg Once monthly Completion of 6
Dapsone 100 mg Daily monthly. Pulses
within 9 months
Single skin Rifampicin 600 mg Single dose Administration of
lesion Ofloxacin 400 mg Single dose single dose
leprosy Minocycline 100 mg Single dose treatment (ROM)
If there is no nerve involvement-rest and analgesics only are used. If

there is nerve involvement-corticosteroids (Prednisolone) are given in
addition to rest and analgesics.
A suggested course of prednisolone for an adult patient is as follows:
40 mg once a day for the first 2 weeks then
30 mg once a day for 3 and 4 weeks
5 mg once a day for 11 and 12 weeks.
The daily dose of prednisolone should not exceed 1 mg/kg body weight.
Treatment of ENL Reaction

ENL reaction occurs only in MB cases.
For mild reactions, bed rest, aspirin or paracetamol are sufficient.
In case of nerve involvement, treatment with prednisolone should be
started immediately during ENL reaction. MDT should be continued
without interruption along with antibiotic treatment.
Completion of Treatment and Cure
Any SSL patient who has taken one dose of ROM should be considered
as cured.
Any PB patient who has taken six months of PB-MDT within 9 months
should be considered as cured.
Any MB patient who has taken 12 months of MB-MDT within 18 months
should be considered as cured
All such patients should be told about the early signs of reactions and
relapse and asked to report any such events promptly to the center.
If the individual has sequelae due to the disease, such as disabilities
he/she should be encouraged and helped to use the available facilities
at the health centre or at an appropriate referral center.
It is important to remember that a leprosy patient who has completed
a full course of treatment should no longer be regarded as a case of leprosy
even if some sequelae of leprosy remain.
Side Effects of Anti-leprosy Drugs (Table 4.20)
Table 4.20: Side effects of anti-leprosy drugs
Common Signs and What to do if side
side effects symptoms effects occur
Dapsone
Anemia Paleness inside the lower eyelids, Give anti-worm treatment
tongue and finger nail and iron tablets. Continue
Tiredness, edema of feet and dapsone
breathlessness
Severe skin Extensive scaling, itching, ulcers Stop dapsone. Refer to
complication in the mouth, the eyes, jaundice hospital immediately.
(Exfoliative and reduced urine output Never restart
dermatitis)
Abdominal Abdominal pain, nausea, and Symptomatic treatment.
symptoms vomiting on high doses Reassure the patient
Liver damage Jaundice (Yellow color Stop dapsone. Refer to
(Hepatitis) of skin, eyeballs and urine), hospital, restart after the
loss of appetite and vomiting jaundice subsides.
Kidney damage Edema of face and feet Stop dapsone. Refer to
(Nephritis) Reduced urine output hospital
Contd....
Contd....
Rifampicin
No significance Reddish coloration of urine, Reassure the patient
saliva and sweat
Hepatitis Jaundice (yellow color of skin, Stop Rifampicin. Refer to
(liver damage) eyeballs and urine) hospital restart after the
jaundice subsides
Flu-like illness Fever,malaise and body ache Symptomatic treatment
Allergy Skin rash Stop rifampicin
Clofazimine
No significance Brownish-red discoloration Reassure the patient, it will
of skin, urine, and body fluids go after completion of
treatment
Ichthyosis Dryness and thickening of the Apply oil to the skin
skin, itching Reassure the patient
Eye Conjuctival dryness Moistening eye drops
Abdominal Abdominal pain, nausea and Symptomatic treatment
Ofloxacin*
Central nervous Sleeplessness, headaches, Symptomatic treatment
system dizziness, nervousness, Reassure the patient
complaints hallucinations
Dizziness Reassure the patient
Discoloration Reassure the patient
of the teeth in
children
Pigmentation Reassure the patient
of the mucous
membranes
symptoms vomiting on high dose Reassure the patient
* With a single dose regimen (ROM) complications are rare. However, this drug is also not
recommended for use in pregnant women and children below five years of age.
Any patient showing a positive skin smear, irrespective of the clinical
classification, should be treated with the MDT regimen for MB leprosy.
When classification is in doubt, the patient should be treated with the
MDT for MB leprosy.
LEPROSY CONTROL
Leprosy Control Programs

1. Medical measures
a. Estimation of the problem
b. Early case detection
c. Multidrug therapy
d. Surveillance
e. Immunoprophylaxis
f. Chemoprophylaxis
g. Rehabilitation
h. Health education
i. Others
2. Social support
3. Program management
4. Evaluation.
Candidate Vaccines
In view of the variable protective effect of BCG vaccine against leprosy,
several alternative vaccine preparations are under development. They
should more appropriately be called Candidate Vaccines (Table 4.21).
Table 4.21: Candidate vaccines
Category I Category II
(based on M. leprae) (based on cultivable mycobacteria)
Killed M. leprae BCG
Killed M. leprae + BCG BCG + M. vaccae
Acetoacetylated M. leprae Killed ICRC bacillus
Health Education
Leprosy Educational Messages

1. Leprosy is the least communicable of all infectious diseases.
2. Four out of five leprosy cases in India are of the noninfectious kind.
3. The treatment available today renders infectious cases noninfectious
in as little as five or six weeks with the help of MDT.
4. Leprosy does not strike overnight. It can take years to manifest itself.
A very prolonged exposure to untreated, infectious cases is necessary
for the signs of the disease to become manifest.
5. Leprosy is neither hereditary nor a curse. It is caused by a germ.
6. Leprosy is completely curable.
7. Leprosy need not result in deformities at all. If detected and treated
early, it leaves no physical scars.
8. The nerve and limb complications that lead to deformity are not
inevitable; they are the result of neglect.
9. Leprosy can be cured even at an advanced stage, though it may not be
possible to correct all the deformities.
10. Leprosy is not a poor mans disease. It can occur in any social or
economic class, even among the affluent.
11. Leprosy is not only an adults disease: 20 percent of all newly detected
cases are children.
12. Leprosy is more than just a medical problem and, for the disease to be
fully treated, community support is as important as medical help.
13. The leprosy patients can stay at home without any risk and continue
to work because, once the treatment is started, the disease is contained.
14. The first signs of leprosy are:
a. A pale or red patch which could be oily, smooth or dry. The patch
is neither painful nor itchy.
b. Loss of hair and lack of sweating in the discolored area.
c. Numbness in the patch.
d. A tingling or ant-crawling sensation along the affected nerve.
15. Leprosy is curable. All it needs is:
a. Early detection
b. Early intervention
c. Sustained treatment
d. Community support throughout.
16. Treatment of leprosy is absolutely free.
Rehabilitation
All cured cases should be provided suitable jobs through government or
private agencies. Modern plastic and orthopedic surgery and physio-
therapy should be used to treat disfiguration and deformities and to restore
appearance and function. Burnt out cases with marked deformities may
be kept in special rehabilitation centers.
Leprosy Organizations in India

There are many voluntary organizations working in the field of leprosy
in India. These include:
1. Leprosy Mission: This was the first voluntary organization for leprosy
work in India. It was started in 1874 by Bailey in Chamba, Himachal
Pradesh. Its headquarter is presently in Purulia, West Bengal.
2. Hind Kushth Nivaran Sangh: This pioneer organization was established
in India in 1947 as a branch of the British Empire Leprosy Relief
Association founded in London in 1925.
3. Gandhi Memorial Leprosy Foundation, Sevagram, Wardha.
4. Belgium Leprosy Center (Polambakkam, Chennai).
5. Danish Save the Children Fund.
6. Bharat Sewashram Sangh, Jamshedpur, Bihar.
7. Kashi Kushth Seva Sangh ,Varanasi, UP.
8. Tapovan, Amravati, Maharashtra.
9. Hindu Mission, Chennai, Tamil Nadu.
Two other important organizations active in the field of leprosy are the
Jalma Central Institute of Leprosy (taken over by ICMR in 1975) and the
Central Leprosy Teaching and Research Institute, Chingleput, Tamil Nadu.
National Leprosy Eradication Program (NLEP)

This program was started in 1983.
Strategies
The program has the following four strategies:
1. Provide domiciliary treatment (MDT) in endemic districts through staff
trained in leprosy.
2. Provide services through mobile leprosy treatment units with the help
of primary health care staff in moderate and low endemic districts.
3. Organize health education to patients, their families and the community
to increase awareness and to remove stigma.
4. To Provide deformity and ulcer care and medical rehabilitation services
to the needy patients.
Infrastructure
It is shown in Table 4.22.
The term elimination refers to the reduction in the prevalence of leprosy
to below one case per 10,000 population. There will be drastic reduction
in the prevalence of a disease to the extent that it no longer remains a
public health problems.
Eradication refers to the complete stopping of transmission as a result
of total disappearance of the diseases causing organism. The aim is to
reduce case load to 1 or less than 1 per 10,000 population.
Modified Leprosy Elimination Campaigns
The Modified Leprosy Elimination Campaigns (MLEC) approach is
actually organizing camps for one or two weeks duration in which services
like cases detection, treatment and referral to reconstruction facilities are
available. A wide level information about camps services and about disease
disseminated through radio, TV, newspapers, loudspeaker, etc.
Table 4.22: Infrastructure
Unit Scale No existing Remarks
Leprosy control unit One per 4.5 lakh 778 In endemic rural
(LCU) or modified LCU population areas headed by a
Medical Officer
Urban leprosy center (ULC) One for 50,000 907 Manned by one
population paramedical worker
responsible to the
MO of a dispensary
or hospital
Survey education and One per 25,000 5744 In low endemic areas,
treatment center (SET) population attached to a PHC or
hospital manned by a
paramedical worker
under guidance of
MO, PHC
Contd...
Contd....
Mobile leprosy treatment 350 In non-endemic
units (MLTU) districts headed by a
Medical Officer.
Temporary hospitalization 290
ward (THW)
Reconstructive surgery 75
units (RSU)
Samples survey cum 40
assessment unit (SSAU)
MLEC has proved quite effective for case finding and has been employed
during phase II. Two rounds of MLEC will be held during phase II; the
specific MLEC strategy is varied according to the endemicity of different
regions:
Action Plan of MLEC (Table 4.23)

Table 4.23: Action plan of MLEC
Endemicity 1 MLEC year 1 2 MLEC year 2 Year 3
High endemic Active search statewise Mixed approach Special action
states in UP, Bihar, West active search and projects for the
Bengal, mix of active VRCs depending elimination of
search and VRCs in upon endemicity of leprosy (SAPEL)
Orissa and Madhya individual districts/ and LECs in tribal
Pradesh pockets areas. In Bihar,
voluntary reporting
centers (VRCs)
Moderate/low VRCs for 2 days VRCs for 2 days For 2 days
endemic with training and with training and
states IEC support support
Very low IEC activity, passive IEC activity,
endemic reporting passive reporting
states
Special Action Projects for the Elimination of Leprosy

Special Action Projects for the Elimination of Leprosy (SAPEL) is an
initiative aimed at providing MDT services to patients living in special
difficult to access areas or situation or to those belonging to neglected
population groups. The most important thing is for the elimination
program to reach everyone who needs MDT services. Innovative and
practical strategies involving mainly operation solutions are be used in
order to provide MDT to these patients.
Global Leprosy Elimination Program

Revised Intensified Strategy 2000-2005 (Modified Leprosy Elimination
Campaign and SAPELS).
Elements of the Intensified Program

1. Identification of endemic districts
2. Integration of MDT services with general health services
3. Monitoring elimination at district level
4. Promoting community action
5. Social marketing/advocacy
6. Re-motivating the research community
7. Prevention of disability and rehabilitation.
FILARIASIS
Filariasis is a global problem. (More than 1.1 billion people live in areas
where there is a risk of infection.) It is estimated that globally 751 million
population is exposed to the risk of filariasis. Half of these cases are in
India.
Burden of Disease
Lymphatic filaria is prevalent in 18 states and union territories. Bancroftian
filariasis is widely distributed while brugian filariasis caused by Brugia
malaya is restricted to 6 satesUttar Pradesh, Bihar, Andhra Pradesh,
Orissa, Tamil Nadu, Kerala, and Gujarat. The WHO has estimated that
600 million people are at risk of infection in South-East Asia and 60 million
are actually infected in the region (WHO-SEARO 1999). There are about
454 million people (75.6%) at the risk of infection with 48 million (80%)
infected with parasite are contributed only by India.
Epidemiology
Human Filarial Infections

Agents
1. Wuchereria bancrofti
2. Brugia malayi
3. Brugia timori
4. Onchocerca volvulus
5. Loa loa
T. perstans
T. streptocerca
6. Mansonella ozzardi
Vectors
1. Culex mosquitoes
2. Mansonia mosquitoes
3. Anopheles mosquitoes
4. Simulum flies
5. Chrysopes flies
6. Culicoides.
Host
Man is the definitive host and mosquito is the intermediate host of
Bancroftian filariasis.
Age All age group
Sex Higher in males
Social factors Urbanization, industrialization, poverty, illiteracy
Climate: It influences the breeding of mosquitoes.
.
Temp 22 to 38 C
Humidity70 percent
Town planningthis disease is associated with bad drainage.Vectors
breed profusely in polluted water.
Incubation period = 8 to 16 months.
Clinical Manifestations
I. Lymphatic filariasis
II. Occult filariasis
Lymphatic Filariasis
a. Asymptomatic amicrofilaremia
b. Asymptomatic microfilaremia
c. Stage of acute manifestation
d. Stage of chronic obstructive lesionselephantiasis of leg, scrotum, arms,
penis, vulva and breasts.
Survey
1. Mass blood survey
a. The thick film
b. Membrane filter concentration
c. DEC provocation test
(DEC100 mgadministered orally, microfilaria begin to reach peak
in 15 minutes and begin to decrease 2 hours later, the blood may be
examined one hour after administration of DEC).
2. Clinical survey
3. Serological test
4. Xenodiagnosis
5. Entomalogical survey.
Control Measures
1. Chemotherapy
2. Vector control.
Chemotherapy
For the individual case treatment: Diethylcarbamazine (DEC) is given for
Bancrofti filariasis in the dose of 6 mg/kg body weight orally daily for 12
days in divided doses after meal (a total of 72 mg per kg of DEC). For the
Brugian filariasis, DEC is given 3 to 6 mg/kg body weight per day up to
total dose of 18 to 72 mg per kg.
Mass treatment: Every member of the community irrespective of infection
are treated with DEC. This mode of control has been tried in many areas.
In some areas selective cases of microfilaria positive are treated with DEC.
Revised strategy: Single dose mass treatment of diethylcarbamazine (DEC)
alone or combined with Ivermectine, repeated at six months or one year,
is claimed to bring down the microfilaria rate by over 80 percent. DEC-
fortified table salt brings the microfilaria rate to a negligible level within
eight months of its introduction.
Vector Control
1. Antilarval measures
2. Antiadult measures
3. Personal prophylaxis.
National Filaria Control Program

It was launched in 1955. In June 1978, the operational component of the
National Filaria Control Program (NFCP) was merged with urban malaria
scheme. The program has been extended to rural areas since, 1994.
1. Delimitation of the problem in the hitherto unsurveyed areas.
2. Control in urban areas through recurrent anti-larval measures and
antiparasitic measures.
3. Filaria clinic were established at the rate of one clinic for 50,000 population.
Work involves collection of night blood samples by home visiting. Each
unit is expected to cover the alloted population in 2 to 2.5 years. Cases
are treated with 72 mg DEC.
National Health Policy

Elimination of lymphatic filariasis by 2015.
DIARRHEA AND DYSENTERY

Diarrhea is one of the most common causes of death in under-five children.
Almost 99 percent of death can be prevented by treating with ORS solution.
Definition
Diarrhea is defined as the passage of loose liquid watery stools. The liquid
stools are usually passed more than three times a day. The recent change
in consistency and character of stools rather than frequency that is more

important.
Acute diarrhea Lasts for three to seven days
Chronic diarrhea Lasts for three weeks or more
What is Not Diarrhea?
Passage of frequent formed stools
Passage of pasty stools in a breastfed child
Passage of stools during or immediately after feeding
Passage of frequent loose greenish yellow stool in the 3rd and 4th day
of life (Transitional diarrhea).
Dysentery
If blood is visible in stools the condition is called dysentery.
Gastroenteritis
The term gastroenteritis is used to describe acute diarrhea.
Problem of Diarrheal Disease

The median diarrheal incidence rate ranges from 1.0 to 4.7 episodes per
year. In slum areas of major cities an incidence as high as 10.5 episodes
per child per year was also reported. About 3 million deaths globally are
associated with diarrhea. India alone account for one-third of these deaths.
Around 65 percent of deaths are due to dehydration, 20 to 35 percent due
to persistent diarrhea and remaining 15 percent due to dysentery. Beside
this there is problem of re-emergence of new strains of Cholera, Escherichia
and Shigella that need to be tackeld properly otherwise nation may face
the severe epidemics.
Upto one-third of total pediatric admissions are due to diarrhea disease
and up to 17 percent of all deaths in indoor pediatric patients are diarrhea
related.
Causes of Diarrhea (Table 4.24)

Table 4.24: Causes of diarrhea
Pathogen % of cases
Virus Rotavirus 15-25
Bacterial Escherichia coli 10-20
Shigella 5-15
Campylobacter jejuni 10-15
Vibrio cholerae 5-10
Salmonella 1-5
Protozoans Cryptosporidium 5-15
No pathogen found 20-30
Diarrhea Control Program

Components of diarrhea disease control programstarted in 1978. Since
1985 to 86 Nation has started oral rehydration therapy.
Short-term
1. Appropriate clinical management
2. Appropriate feeding
3. Chemotherapy.
Long-term
1. Better MCH care practices
a. Maternal nutrition
b. Child nutrition :
i. Promotion of breastfeeding
ii. Appropriate weaning practices
iii. Supplementary feedings.
2. Preventive strategies
a. Sanitation
b. Health education
c. Immunization
d. Antifly measures
3. Preventing diarrhea epidemics.
CHOLERA
Cholera is a notifiable disease all over India as well as to WHO. Being a
disease of poor sanitation, poor water, and food hygiene, it occurs as
endemic, sporadic and pandamic.
Typical cases are characterized by the sudden onset of profuse, effortless,
watery diarrhea followed by vomiting, rapid dehydration, muscular
cramps and suppression of urine formation.
Case fatality rate is 30 to 40 percent varies from 10 to 80 percent.
Epidemiology, clinical features, complication and investigation.
Epidemiology
Agent
Vibrio cholerae: There are two types of vibrio cholerae:
1. Classical vibrio cholerae
2. ELT or vibrio cholerae
There are two serotypes:
a. Ogawa
b. Inaba
Source of infection: Contaminated food and water.

Period of communicability: The patient is infective during the later part of
incubation period and during the periods of disease and convalescence
which lasts for 7 to 10 days.
Mode of transmission: Feco-oral route
Incubation period: One to five days , usually 12 hours to 2 days.
Clinical Features
Stage of evacuation
1. Profuse vomiting.
2. Frequent loose motions, watery, copious, with flakes of mucus (Rice
water stool).
Stage of collapse
1. Hypovolemic shock, due to massive diarrhea and vomiting.
2. Tachycardia and tachypnea.
3. Oliguria.
4. Cold and clammy skin.
Stage of recovery
1. Vomiting and loose motions decrease.
2. Hydration improves.
3. Normal temperature returns.
Atypical Presentation
Cholera sicca: It is a fatal variety, in which there is very little or no diarrhea
or vomiting, and patient develops collapse very rapidly with overt
manifestations.
Complications
1. Hypovolemic shock
2. Acute renal failure
3. Electrolyte disturbances (hypokalemia)
4. Enteritis
5. Cholecystitis
6. Stroke in the elderly patient.
Investigations
1. Leucocytosis with polymorphonuclear predominance.
2. Stool swab, for demonstrating darting motility, of V. cholerae
3. Stool culture for V. cholerae
4. Slide agglutination using polyvalent anti-cholera, dignostic serum.
Control of Cholera
1. Verification of the diagnoses
2. Notification
3. Early case finding
4. Establishment of treatment centers
5. Rehydration therapy
6. Adjuncts to therapy
7. Epidemiological investigation
8. Sanitation measures
9. Chemoprophylaxis
10. Vaccination
11. Health education.
Rehydration Therapy
Oral rehydration: The introduction of oral rehydration, by WHO in 1971,

has greatly simplified the treatment of cholera and other acute diarrhea
diseases. The aim of oral fluid therapy is to prevent dehydration and reduce
mortality (Tables 4.25 and 4.26).
Table 4.25: Composition of ORSbicarbonate
Ingredient Quantity
Sodium chloride 3.5 g
Sodium bicarbonate 2.5 g
Potassium chloride 1.5 g
Glucose (dextrose) 20.0 g
Potable water 1 liter
Table 4.26: Composition of ORScitrate

Ingredient Quantity
Sodium chloride 3.5 g
Trisodium citrate dehydrate 2.9 g
Potassium chloride 1.5 g
Glucose 20.0 g
Potable water 1 liter
Assessment of Dehydration (Table. 4.27)
Table. 4.27: How to assess your patient
FOR DEHYDRATION FOR OTHER PROBLEMS
A B C
1. Ask about: Diarrhea Less than 4 liquid stools per day 4 to 10 liquid stools per day More than 10 liquid stools per day Longer than 14 days duration. Blood in the stool
Vomiting None or a small amount Some Very frequent
Thirst Normal Greater than normal Unable to drink
Urine Normal A small amount, dark No urine for 6 hours
2. Look at: Condition Well, alert Unwell, sleepy or irritable Very sleepy, unconscious Severe undernutrition
floppy or having fits
Tears Present Absent Absent
Eyes Normal Sunken Very dry and sunken
Mouth and Wet Dry Very dry
Tongue
Breathing Normal Faster than normal Very fast and deep
3. Feel: Skin A pinch goes back quickly A pinch goes back slowly A pinch goes back very slowly
Pulse Normal Faster than normal Very fast, weak or you cannot
feel it
Fontanelle Normal Sunken Very sunken
(in infants)
4. Take temperature Fever-38C (or 101F) or greater
5. Weigh if possible Loss of less than 25 grams Loss of 25-100 grams Loss of more than 100 grams
for each kilogram of weight for each kilogram of weight for each kilogram of weight
6. Decide The patient has no signs of If the patient has 2 or more If the patient has 2 or more of If your patient has: Then:
dehydration of these signs, he has these danger signs, he has Blood in the stool and Treat with an appropriate oral
some dehydration severe dehydration diarrhea for less than antibiotic for shigella dysentery
14 days If this child is also
Dehydrated
Severely undernourished or
Less than 1 year of age,
reassess the childs progress
in 24-48 hours.
For the severely undernourished
child, also refer for treatment of
severe undernutrition
Diarrhea for longer Continue feeding and refer for
than 14 days with or treatment
without blood Show the mother how to cool the
Communicable Diseases
Severe undernutrition child with a wet cloth and fanning.

Fever - 38 C Look for and treat other causes
(or 101F) or greater (for example, pneumonia, malaria).
59
Treatment of Mild Dehydration (Table 4.28)

1. Amount of ORS solution to give in first four to six hours
2. If the mother can remain at the health center
Show her how much solution to give her child.
Show her how to give ita spoonful every one to two minutes.
Check from time to time to see if she has problems.
Table. 4.28: Amount of ORS solution
Patients age1 2 4 6 8 10 12 18 2 3 4 6 8 15 adult

months years
Patients weight in
Wt in kg Under 5 5-7.9 8-10.9 11-15.9 16-29.9 30 or over
kilograms
ORS solution (ml) 200-400 400-600 600-800 800-1000 1000-2000 2000-4000
1
Use the patients age only when you do not know the weight.
Note: Encourage the mother to continue breastfeeding.
If the patient wants more ORS, give more.
If the eyelids become puffy, stop ORS and give other fluids. If diarrhea continues, use ORS again
when the puffiness is gone.
If the child vomits, wait 10 minutes and then continue giving ORS, but more slowly.
Treatment of Severe Dehydration (Flow chart 4.3)
Flow chart 4.3: Treatment of severe dehydration

Follow the arrows. If the answer to the question is yes, go across. If it is no, go down.
Can the child drink? 1. Start treatment with ORS solution,

Yes as in Treatment Plan B
2. Send the child for IV treatment
No
Are you trained to 1. Start rehydration using the tube
use a nasogastric Yes 2. If IV treatment is available nearby,
tube for rehydration? send the child for immediate
IV treatment
No
URGENT: Send
the child for IV
treatment
Note: If the child is above two years of age and cholera is known to be currently occurring in your
area, suspect cholera and give an appropriate oral antibiotic once the child is alert.
Intravenous Rehydration
The recommended dose of the IV fluid to be given is 100 ml/kg divided
as follows (Table 4.29).
Table 4.29: Treatment plan for rehydration therapy
Age First give 30 ml/kg in Then give 70 ml/kg in
Infants (under 12 months) 1 hour 5 hours
Older 30 minutes 2 hours
Maintenance Therapy (Table 4.30)
Table 4.30: Maintenance therapy

Amount of diarrhea Amount of oral fluid
Mild diarrhea 100 ml/kg body weight per day until
(not more than one stool every 2 hours or diarrhea stops
longer or less than 5 ml stool per kg per hour)
Severe diarrhea Replace stool losses volume for
(more than one stool every 2 hours, or volume; if not measurable, give
more than 5 ml of stool per kg per hour) 10-15 ml/kg body weight per hour
For more than 25 years WHO and UNICEF have recommended a single
formulation of glucose based Oral Rehydration Salts (ORS) to prevent or
treat dehydration from diarrhea irrespective of the cause or age group
affected. This product, which provides a solution containing 90 mEq/l of
sodium with a total osmolarity of 311 mOsm/l, has proved effective and
without apparent adverse effects in worldwide use. It has contributed
substantially to the dramatic global reduction in mortality from diarrheal
diseases during the period.
For the past 20 years, numerous studies have been undertaken to develop
an improved ORS. The goal was a product that would be at least as safe
and effective as standard ORS for preventing or treating dehydration from
all types of diarrhea but which, in addition, would reduce stool output or
have other important clinical benefits. One approach has consisted in
reducing the osmolarity of ORS solution to avoid possible adverse effects
of hypertonicity on net fluid absorption. This was done by reducing the
solution super glucose and salt (NaCl) concentrations.
Oral rehydration therapy is now preventing about one million
dehydration deaths (Table 4.31).
Table 4.31: Oral rehydration therapy
Reduced osmolarity ORS Grams/liter Reduced osmolarity ORS mmol/liter
Sodium chloride 2.6 Sodium 75
Glucose anhydrous 13.5 Chloride 65
Potassium chloride 1.5 Glucose, anhydrous 75
Trisodium citrate, dehydrate 2.9 Potassium 20
Citrate 10
Total osmolarity 245
Adjuncts to Therapy
Antibiotics used in the treatment of cholera (Table 4.32)
Table 4.32: Antibiotics used in the treatment of cholera
Antibiotics (a) Children Adults
Doxycycline once 300 mg (b)
Tetracycline 4 times a 12.5 mg/kg 500 mg
day for 3 days
Trimethroprim (TMP) TMP 5 mg/kg and SMX TMP 160 mg
sulfamethoxazole (SMX) 25 mg/kg (c) SMX 800 mg
twice a day for 3 days
Furazolidone 4 times 1.25 mg/kg 100 mg (d)
a day for 3 days
a. Erythromycin and chloramphenicol may also be used when none of the other recommended
antibiotics are available, or when Vibrio Cholerae 01 is resistant to the latter.
b. Doxycycline is the antibiotic of choice for adults (excepting pregnant women since a single
dose suffices.
c. TMP-SMX is the antibiotic of choice for children. Tetracycline is equally effective, but is not
available everywhere in pediatric form.
d. Furazolidone is the antibiotic of choice for pregnant women.
Disinfection
Both concurrent and terminal disinfections are important in respect of
cholera. This can be done by the following measures:
a. Mix with cholera stools and vomit an equal quantity of 5 percent lysotol
of 5 percent cresol or 30 percent bleaching powder. Allow to stand for
2 hours and bury the mixture.
b. If stools and vomit fall on the floor, the area around the patient should
be covered with a thin layer of lime or bleaching powder.
c. A practical and cheap method is to immerse the pans and receptacles
containing vomit and stools in boiling water.
d. Immerse the soiled clothes in boiling water or in 2 percent lysotol for
some time.
e. Whitewash the walls and floors with lime or throw boiling water on
them. Mud floors may be burnt with cowdung cakes.
f. Boil the utensils and burn cheap fomites.
g. Cots and linen may be disinfected by 10 percent formalin, 5 percent
lysotol spray or exposure to sun. Steam disinfection may also be done.
h. Wash hands with soap and water. Dipping hands in 1 percent lysotol is
also useful.
i. Well or tank water should be disinfected with bleaching powder so as
to get 1.5 to 2.0 ppm of chlorine. This should be the first step when a
report is received about occurrence of cholera. Potassium permanganate
should not be relied upon.
Diarrheal Diseases Control Program

The National Cholera Control Program is now termed has diarrheal
diseases control program
Investigation of an Epidemic
The occurrence of an epidemic always signals some significant shift in
the existing balance between the agent, host and environment. It calls
for a prompt and thorough investigation to prevent further spread.
Emergencies caused by epidemics remain one of the most important role
to play in the investigation of epidemics. The objectives of an epidemic
investigation are:
a. To define the magnitude of the epidemic outbreak or involvement in
terms of time, place and person.
b. To determine the particular conditions and factors responsible for
occurrence of the epidemic
c. To identify the cause, source(s) of infection, and modes of transmission
to determine measures necessary to control the epidemic
d. To make recommendations to prevent recurrence.
An epidemic investigation calls for inference as well as description.
Frequently, epidemic investigations are called for after the peak of the
epidemic has occurred. In such case, the investigation is mainly
retrospective. No step by step approach applicable in all situations can
be described like a cook - book . However, in investigating an epidemic,
it is desired to have an orderly procedure or practical guidelines as outlined
below which are applicable for almost any epidemic study.
Verification of Diagnosis
A clinical examination of a sample of cases may well suffice. Laboratory
investigations wherever applicable, are most useful to confirm the
diagnosis but the epidemiological investigations should not be delayed
until the laboratory results are available.
Confirmation of the Existence of an Epidemic

This is done by comparing the disease frequencies during the same period
of previous years. An epidemic is said to exist when the number of cases
(observed frequency) in excess of the expected frequency for the
population, based on past experience. An arbitrary limit of two standard
errors from the endemic occurrence is used to define the epidemic
threshold for common diseases such as influenza, often the existence of
an epidemic is obvious needing no such comparison, as in the case of
commonsource epidemics of cholera, food poisoning and hepatitis A.
Defining the Population at Risk

Obtaining a map of the area: Before beginning the investigation, it is necessary
to have a detailed and current map of the area. It should contain
information concerning natural landmarks, roads and the location of all
dwelling units along each road or in isolated areas. Within each section,
the dwelling units (houses) may be designed by numbers.
Counting the population: The denominator may be related to the entire
population or sub groups of a population. It may also be related to total
events. Without an appropriate denominator of population at risk attack
rates cannot be calculated.
Rapid Search for all Cases and their Characteristics
Medical survey: Concurrently a medial survey should be carried out in a

defined area to identify all cases including those who have not sought
medical care, and those possibly exposed to risk.
Epidemiological case sheet: The epidemiologist should be armed with an
epidemiological case sheet for collecting data from cases and from
persons apparently exposed but unaffected. The epidemiological case sheet
or case interview form should be carefully designed (based on the
findings of a rapid preliminary inquiry) to collect relevant information.
This includes: name, age, sex, occupation social class, travel, history of
previous exposure, time of onset of disease, signs and symptoms of illness,
personal contacts at home, work, school and other places, special events
such as parties attended, foods eaten and exposure to common vehicles
such as water, food and milk; visits out of the community, history of
receiving injections or blood products, attendance at large gathering, etc.
The information collected should be relevant to the disease under study.
For example, if the disease is food-borne, detailed food histories are
necessary. A case review form will ensure completeness and consistency
of data collection. If the outbreak is large, it may not be possible to interview
all the cases (e.g. influenza). In such cases, a random sample should be
examined and data collected.
Searching for more cases: The patient may be asked if he knew of other
cases in the home, family, neighborhood, school, work place having an
onset within the incubation of the index case. Cases admitted to the local
hospitals should also be taken into consideration. This may reveal not
only additional cases but also person-to-person spread. The search for
new cases (secondary cases) should be carried out everyday, till the area
is declared free of epidemic. This period is usually taken as twice the
incubation period of the disease since the occurrence of last case.
Evaluation of Ecological Factors

An investigation of the circumstances involved should be carried out to
undertake appropriate measures to prevent further transmission of the
disease. Ecological factors which have made the epidemic possible should
be investigated such as sanitary status of eating establishments, water
and milk supply; breakdown in the water supply system; movements of
the human population, atmospheric changes such as temperature humidity
and air pollution, population dynamics of insects and animal reservoirs.
The outbreak can be studied in a case control fashion. One of the primary
concerns of the epidemiologist is to relate the disease to environmental
factors to know the source(s) of infection, reservoirs and modes of
transmission.
Further Investigation of Population at Risk

A study of the population at risk or a sample of it may be needed to obtain
additional information. This may involve medical examination, screening
tests, examination of suspected food, faces, blood samples, biochemical
studies, assessment of immunity status, etc. The approach may be
retrospective or prospective. For example, serological study may reveal
clinically inapparent cases and throw light on the pathogenesis of the
condition. Healthy individuals (those who are not ill) from the same
universe may be studied in a case control fashion. This will permit
classification of all members as to:
a. Exposure to specific potential vehicles
b. Whether ill or not.
Data Analysis
The data collected should be analyzed on ongoing basis, using the classical
epidemiological parameters time, place and person. If the disease agent
is known, the characteristics of time, place and person may be rearranged
into the Agent-Host-Environment model.
Time: Prepare a chronological distribution of dates of onset and construct
an epidemic curve, Look for time clustering of cases. An epidemic curve
may suggest: (a) a time relationship with exposure to a suspected source,
(b) whether it is common-source or propagated epidemic, and (c) whether
it is a seasonal or cyclic pattern suggestive of a particular infection.
Place: Prepare a spot map (geographic distribution) of cases, and if
possible their relation to possible, sources of infection, e.g. water supply,
air pollution, foods eaten, occupation, etc. Clustering of cases may indicate
a common source of infection. Analysis of geographic distribution may
provide evidence of the source of disease and its mode of spread.
Person: Analyze the data by age, sex, occupation and other possible risk factors.
Determine the attack rates/case fatality rates, for those exposed and those not
exposed and according to host factors. For example, in most food borne outbreaks,
food-specific attack rates must be calculated for each food eaten to determine the
source of infection.
The purpose of data analysis is to identify common event or experience,
and to delineate the group involved in the common experience.
Formulation of Hypotheses
On the basis of time, place and person distribution or the Agent-Host-
Environment model, formulate hypotheses to explain the epidemic in
terms of:
a. Possible source
b. Causative agent
c. Possible modes of spread, and
d. The environmental factors which enabled it to occur.
These hypotheses should be placed in order of relative likelihood.
Formulation of a tentative hypotheses should guide further investigation.
Testing of Hypotheses
All reasonable hypotheses need to be considered and weighed by
comparing the attack rates in various groups for those exposed and those
not exposed to each suspected factors. This will enable the epidemiologist
to ascertain which hypotheses is consistent with all the known facts. When
divergent theories are presented, it is not easy to distinguish immediately
between those which are sound and those which are merly plausible.
Therefore, it is instructive to turn back to arguments which have been
tested by the subsequent course of events.
Writing the Report

The report should be complete and convincing with all the information of
the epidemic in prescribed format.
SCABIES
It is a contagious disease more common in low socioeconomic group,
who have poor personal hygiene, more so in children.
Epidemiology
Agent
Sarcoptes scabiei
Source of infection: Infected patients and their clothes and linen.
Mode of Transmission
1. Direct contact with patients
2. Fomites.
Period of communicability: Till such time as the infection persists in untreated
cases, usually four to six weeks. Patient becomes noninfective within three
days of effective treatment.
Incubation period: Usually seven days.
Secondary attack rate: Around 80 percent in children and around 30 percent in
adult contacts.
Host
1. Age: Maximum incidence in school going children and occurs at all
ages.
2. Sex: Equal in both sexes.
3. Poor personal hygiene.
Environmental and Social Factors

1. Maximum incidence in winter season
2. Over crowding
3. Low socioeconomic living style
4. Limited availability of water for washing.
Clinical Features
1. Severe itching, which is worse at night.
2. Common with other family members.
3. Burrow is the greyish, serpentine, dotted line on the skin which
represents the tunnel made by the female mite.
4. Sites of Burrows are:
a. Interdigital folds
b. Flexor aspects of wrists
c. Anterior axillary folds
d. Umibilicus
e. Lower abdomen
f. Genitalia
g. Buttocks and thighs.
Complications
1. Secondary infections
2. Urticaria and eczema
3. Glomerulonephritis.
Variants
1. Scabies in clean and healthy person.
2. Scabies incognito: It occurs in a patient taking steroids.
3. Norwegian scabies: It occurs in immunocompromised persons.
4. Facial scabies in infants.
a. Secondary infections should be treated.
b. All the drugs used locally should be applied below the neck on
three consecutive days.
Control of Scabies
1. Benzyl Benzoate
a. First application with 25% BB Lotion
b. Second application 12 hours after 1st application
c. Bath given 12 hours after 2nd application.
2. HCH 0.5 to 1.0 percent (Lindane)should be rubbed on affected skin
at an interval of two to three days.
3. Tetmosal 5 percent3 daily applications.
4. Sulphur ointment2.5 to 10 percentdaily for four days.
SEXUALLY TRANSMITTED DISEASES

The sexually transmitted diseases are a group of communicable diseases
that are transmitted predominantly by sexual contact and caused by wide
range of bacterial, viral, protozoal and fungal agents and ectoparasites.
What are Sexually Transmitted Diseases?

Sexually transmitted diseases, commonly called STDs, are diseases that
are predominantly spread by sexual contact.
One can get sexually transmitted disease from sexual activity that
involves the mouth, anus, vagina, or penis.
There are at least 25 different types of common STDs. Most of these are
curable.
Some of the viral STDs, which cannot be cured, are preventable. for
example hepatitis B can be prevented by vaccination.
Why is STD Control an Important Component of

HIV/AIDS Prevention?
STDs increase the risk of acquiring HIV or transmitting HIV
Treatment of STD reduces the risk of transmission of HIV
Prevention of STD will prevent the sexual transmission of HIV, which
is the main route of HIV transmission
STDs present earlier than HIV/AIDS. Hence, it offers an opportunity
to counsel the patient for behavior change and condom use
In a person with HIV/AIDS, repeated STD increases the HIV viral load
and therefore shortens the life span of HIV
STDs do not become AIDS.
What are the Symptoms of STDs?

At Least Half of STDs in Women do not produce any Symptoms
Some of the common symptoms of STD are:
Ulcers, sores or, warts near the penis or vagina. In a person who practices
oral or anal sex, these ulcers or blisters may be present around the mouth
or anus.
Discharge from the urethra (males) or vagina or more specifically cervical
discharge in women. This group of individuals may also complain of
pain or burning sensation while passing urine.
Swellings in the groin , swelling of the scrotum in males.
Chronic lower abdominal pain in women, may be a symptom of STD.
How can One Protect Oneself from STDs?

Here are some basic steps that one can take to protect oneself from STDs:
Abstinence or not having sex or sexual relations: This is the only sure
way to prevent STDs. However, this is not practical for a lifetime.
Abstinence could be recommended pre-maritally. Delaying sexual
debut can reduce the risk of STD/HIV transmission.
Practice monogamy: This means have sex with only one person who is
also mutually faithful.
Use a latex condom every time one has sex (If one uses a lubricant,
make sure it is water-based).
Limit the number of sexual partners. The more partners one has, the
more likely such a person is to get an STD.
Choose sex partners with care. Dont have sex with persons who have
multiple sexual partners or have an STD.
Get checked for STDs.
Dont use alcohol or drugs, before having sex. One may be less likely
to use a condom if one is drunk or high.
Know the signs and symptoms of STDs. Look for them in both the sex
partners.
How can Reinfection of STDs be prevented?

Reinfection is very common, especially among women. Men and women
can prevent reinfection by:
Getting prompt, correct and complete treatment if they do have an STD.
Any genital symptoms such as discharge or burning during urination
or an unusual sore or swelling should be a signal to stop having sex
and to consult a doctor immediately. Even if there are no symptoms
but one thinks that he/she is infected, it is recommended to avoid sexual

contact and to consult a health care provider.
Getting the sexual partner also treated concurrently. If one is told that
he/she has STD and receives treatment, such person should notify all
of his/her recent sex partners, so that they can see a doctor and be
treated.
Avoiding sex during treatment for a STD or use condoms during this
time.
Using condoms correctly, continuously (from the beginning of sex to the end)
and consistently (every time) one has sex. The use of latex or ployurethane
condoms during vaginal intercourse can prevent the transmission of
STDs. However, condoms do not provide complete protection from all
STDs. Sores and lesions of STDs on infected men and women may be
present in areas not covered by the condom, resulting in transmission
of infection to another person.
Reducing the number of sex partners, reducing the frequency of change
of partner, practicing sexual abstinence, or limiting sexual contact to
one uninfected partner, are other options.
What are the Approaches to STD Management?
Etiological Diagnosis
An attempt is made to identify the specific cause based on laboratory
investigations . Note that VDRL test is a test that can only tell whether a
person has been infected with syphilis or not. It is not a test that detects all
VDs or STDs.
Clinical Diagnosis
Diagnosis is made on the basis of clinical symptoms. It is possible to
diagnose many STD and on the basis of clinical presentation. But
misdiagnosis can lead to failure of treatments and continued transmission.
Hence, syndromic approach is the most useful and effective approach.
What is the Syndrome Approach?

It is a scientific method of treating STDs in health fecilities that lack
laboratory equipments or skills to make an etiological diagnosis.
A syndrome is a combination of the symptoms complained by patients
and signs found on examination. Even though different organisms cause
STDs these organisms give rise to only a limited number of syndromes.
Syndromic management is based on the identification of a consistent
group of symptoms and easily recognizable signs.
The provision of treatment will deal with the majority of organisms
responsible for producing the syndrome.
The Steps Involved in Adopting a Syndromic Approach

Classify the main causative agents by clinical syndromic they produce.
Choose the appropriate treatment flow-chart for each syndrome.
Choose the appropriate treatment flow-chart if laboratory investigations
are available.
Treat the patients for all the important causes of the syndrome as per
directions on the respective flow-chart, after examination of the patient.
Ensure that the partners are treated, patients are educated, and that the
use of condoms promoted.
Syndromic Case Management necessitates
Clinical Examination of the Patient
It is not symptomatic treatment! identifying the syndromes in STD
(Table 4.33).
Table 4.33: The syndromes in STD are grouped
Common clinical Most common Etiology
signs causes
Genital ulcer in Genital ulcer on Syphilis Treponema pallidum
males or females penis or scrotum Chanchroid Hemophilus ducreyi
in men, on labia, Genital Herpes Herpes simplex
vagina or cervix Lymphogranulo- virus, Chlamydia
in women ma venereum, trachomatis ( L1-L3)
Donovanosis Calynomato-bacterium,
granulomatis
Urethral discharge, Urethral discharge Gonorrhoea N. gonorrhoea
dysuria in males on milking urethra Non-gonococcal C. trachomatis or
urethritis ureplasma urealyticum
Vaginal discharge Abnormal vaginal Cervicitis: N. gonorrhoea
and/or cervical Gonorrhoea C. trachomatis
discharge Chlamydial
Vaginal inflamma- infection
tion cervical
friability Vaginitis: Trichomonas vaginalis
cervical motion Trichomoni- Gardenella vaginalis,
tenderness asis anaerobes
Bacterial- Candida albicans
vaginosis
Candidiasis
Lower abdominal Adnexal + cervical Gonorrhoea N. gonorrhoea
pain in women, motion tenderness Chlamydial C. trachomatis
dyspare-unia, Vaginal or cervical infection
irregular bleeding discharge (some- Anaerobes Anaerobes
times) fever
Inguinal swelling Inguinal lympha- Lymphogranu- C. trachomatis (L1-L3)
or bubo in males denopathy with loma-venereum
or females or without ulceration
Scrotal swelling or Red + edematous Gonorrhoea N. gonorrhoea
pain in males scrotum Non-gonococcal C. trachomatis or
Urethral signs Urethritis Ureplasma
Urealyticum
Syndromic Case Management

The aim of syndromic case management is to identify one of these six
syndromes and manage it accordingly. It includes only those syndromes
that are caused by organisms, which both respond to treatment and lead
to severe consequences if left untreated. Some STD syndromes such as
genital warts are not included in this program, as the presence of these
lesions contributing to the transmission of HIV has not been adequately
documented.
Roles and Responsibilities of the Doctors while giving
Quality Care for Patients with STD
Compliance: Ensure that the patient takes full course of treatment as
prescribed. This means that you need to spend some time communicating
with him/her the importance of completing the treatment.
Contact treatment: Treat the sexual partner (s) for the same STD condition
and initiate the treatment of the partner at the same time as the patient.
Partner treatment is necessary even if the partner does not have symptoms.
Condom promotion: Advice, prescribe, distribute or demonstrate how
condoms must be used correctly. Insist on use of condoms every time
there is sexual contact.
Counseling counsel: The patient or refer him/her for counseling. Counseling
includes risk reduction counseling and pre-test counseling for HIV/AIDS.
Continued support: Follow-up the patient to ensure that there is total cure
of the condition, not only disappearance of syndromes. During follow-
up once more emphasize on safer behaviors. Refer the patient to a STD
specialist if there is no improvement after treatment or developing of
complications such as super- added infection or sequel of the condition.
Collection of essential data: Maintenance of basic records for STD patients
will not only help to document follow-up but will also be useful to track
social, demographic and behavioral characteristics of patients with STD.
Advantages of the Syndromic Case Management
The treatment for each syndrome is immediate and is given at the first
line health facility.
There is wider access to treatment catering to a large needy population.
There are ample opportunities for preventive measures and promotion
of condom use.
Syndromic Case Management
Scientific
Simple
Free from errors in clinical judgment
Effective against mixed infections

Cost-effective in the long run as it does not require laboratory tests.
Treatment for the Most Common STD Associated Syndromes
Treatment of Urethral Discharge

Ciprofloxacin 500 mg as a single oral dose
Alternatively, the patient may be treated with:
Norfloxacin 800 mg single oral dose, or
Cefixime 400 mg single oral dose, or
Ceftriaxone 250 mg single IM dose, or
Spectinomycin 2 g single IM dose.
Plus
Give doxycycline 100 mg orally twice daily for 7 to 14 days for (chlamydial
urethritis). Alternatively, the following drugs may be used:
Tetracycline 500 mg orally 4 times a day for 7 days, or
Erythromycin 500 mg orally 4 times a day for 7 days.
Genital Ulcers
Treatment for syphilis
Give Benzathine pencillin 2.4 million units intramuscularly
Alternatively, if the person is allergic to penicillin, use;
Tetracycline 500 mg orally 4 times a day for 15 days , or
Doxycycline 100 mg orally twice daily for 15 days, or
Erythromycin 500 mg orally 4 times a day for 15 days.
Plus
Treatment for chancroid
Give Erythromycin 500 mg orally 4 times, daily for 7 days
Alternatively, the following may be used:
Ciprofloxacin 500 mg single oral dose, or
Spectinomycin 2 g single IM dose, or
Trimethoprim 160 mg/Sulfamethoxazole 800 mg (2 tablets) orally twice
daily for 7 days.
Treatment for herpes
Acyclovir 200 mg orally 5 times daily for 7 days.
Treatment of Vaginal Discharge

Metronidazole 2 g as a single oral dose, or
Metronidazole 400 mg given orally twice daily for 7 days.
Note: Do not use Metronidazole in the first trimester of pregnancy.
Plus
Nystatin (100,000 units one pessary), inserted intravaginally daily at
night for 14 days (for vaginal candidiasis ), or
Miconazole or Clotrimazole 200 mg may be inserted into the vagina
daily for 3 days, or
Clotrimazole 500 mg is inserted into the vagina once only.
Ciprofloxacin 500 mg in a sinlge oral dose for gonococcal infection, or
Doxycycline 100 mg orally twice daily for 7 to 14 days for chlamydial
infection, or
Tetracycline 500 mg orally four times a day for 7 days, or
Erythromycin 500 mg orally four times a day for 7 days.
Note: Ciprofloxacin, Doxycycline and Tetracycline should not be used
in pregnancy.
Treatment of Lower Abdominal Pain in the Female

Treatment for gonorrhea
Ciprofloxacin 500 mg single oral dose, or
Plus
Treatment for chlamydial infection:
Doxycycline 100 mg oral twice daily for 14 days, or
Tetracycline 500 mg orally four times daily for 14 days ,or
Erythromycin 500 mg orally four times daily for 10 days.
Treatment for anaerobic bacterial infection:
Metronidazole 400 mg given orally twice daily for 14 days.
Note: Ciprofloxacin, Doxycycline and Tetracycline, should not be used
during pregnancy and lactation, Metronidazole should not be used in
the first trimester of pregnancy.
National STD Control Program

It was started in India as a pilot project in 1949. It has following main
components:
a. Teaching and training
b. Research
c. Community education
d. Epidemiology
The control of STD now forms part of the National AIDS Control
Program.
BIBLIOGRAPHY
1. A Guide to Leprosy Control WHO, 1980.
2. Annual Report: Ministry of Health and Family Welfare, Govt of India,
1998-99.
3. Das BC, Malini Shobha, Text of Community Medicine with Recent Advances,
1st edn, 2003.
4. Govt of India, LeprosyNational Leprosy Eradication Programme in India
1989. Guidelines for Multidrug Treatment in Endemic Districts, Leprosy,
Division, DGHS, New Delhi, 1989.
5. Govt of India. TB India: RNTCP Status Report. Central TB Division, DGHS,
Ministry of Health and Family Welfare, New Delhi, 2001.
6. Govt of IndiaSIDA, WHO. Review Committee Report, 1992.
7. Govt. of India. Annual Report 2001-2002. Ministry of Health and Family
Welfare. Govt of India.
8. Gupta MC and Mahajan BK Textbook of Preventive and Social Medicine, 3rd
edn, 2003.
9. Job CK, et al Leprosy: Diagnosis and Management, Hind Kusht Nivaran
Sangh, New Delhi, 1975.
10. Kishore J , National Health Programmes of India, 4th edn, 2002.
11. WHO. Revising challenges towards the elimination of leprosy (Leprosy
Elimination Project. Ind Join Lepr 2000; 72(1 :2000).
12. WHO: Techn Rep Ser 675, 1982.
16. Worndorff van Diepen. Clafazimine resistant leprosy. A case report. Int Join.
Lepre 1982; 50:139-42.
Chapter
5 Noncommunicable
Diseases
CHAPTER OUTLINE
CORONARY HEART DISEASE HYPERTENSION
OBESITY RHEUMATIC HEART DISEASE
MENTAL HEALTH DIABETES MELLITUS
CANCER CAUSES OF CANCER
NATIONAL CANCER CONTROL PROGRAM (NCCP)
Chronic noncommunicable diseases are assuming increasing importance

among the adult population in both developed and developing countries.
The impact of chronic disease on the lives of people is serious when
measured in terms of loss of life, disablement, family hardship and
poverty and economic loss to the country. Some cases of non-communicable
diseases are kept for case presentation. They are discussed briefly in the
following pages.
CORONARY HEART DISEASE

Coronary heart disease (CHD) is becoming a major health problem in
India. The WHO has drawn attention to the fact that CHD is our modern
epidemic. However, there is no national program on prevention in
the offing. As per current estimates at least 50 million people are suffering
from CHD.
Prevalence rate (Age group 35-64 years).
10.9% in urban male
5.5% in rural male
10.2% in urban female
6.4% in rural female.
Definition
Coronary heart disease has been defined as impairment of heart function
due to inadequate blood flow to heart compared to its needs, caused by
obstructive changes in the coronary circulation to the heart.
Manifestations
a. Angina pectoris of effort
b. Myocardial infarction
Noncommunicable Diseases 77
c. Irregularities of heart
d. Cardiac failure
e. Sudden death.
Measurement the Burden of Disease

It can be done by:
a. Proportional mortality ratioin men 30 percent of deaths and women
in 25 percent of deaths in western countries
b. Loss of life expectancy
c. CHD incidence rate
d. Age specific death rate
e. Prevalence rate
f. Case fatality rate
g. Measurement of risk factor levels
h. Medical care.
Epidemiology
No single agent can be pinpointed as the causative agent for coronary
heart disease. The disease is caused by interaction of a variety of factors
web of causation of myocardial infarction.
Risk Factors for CHD
Nonmodifiable Risk Factors

Age40 plus
Sexpredominantly male
Postmenopausal female
Personalitiestype A
Family history of CHD
Genetic factors are probably the most important determinants of a
given individuals TC and LDL levels.
Modifiable Risk Factors

Cigarette smokingit is responsible for 25 percent of CHD death
under 65 years in men.
Hypertensionaccelerates the atherosclerotic process
Serum cholesterol>220 mg/dl is risk for CHD
Diabetesthe risk of CHD is two-three times higher in diabetes.
Obesity and sedentary habitsphysical exercise increases the HDL
levels
Stress.
Complications of Myocardial Infarction

Early
a. Arrhythmias
b. Cardiac failure
c. Embolization
d. Cardiac rupture
i. Ventricular septal defect
ii. Rupture through free wall causing cardiac tamponade.
e. Papillary muscle dysfunction
f. Cardiogenic shock.
Late
a. Ventricular aneurysm.
b. Dresslers syndrome
c. Shoulder hand syndrome.
Medical Treatment
For Angina
a. Control of risk factors like hypertension, diabetes, etc.
b. Bedrest and sedatives
c. Nitratesisosorbide dinitrate-nitroglycerine ointment two percent
d. -blockers
e. Calcium channel blockers.
For Unstable Angina and Myocardial Infarction

Relief of pain
i. Complete bedrest
ii. Nitrates sublingually and intravenously
iii. Analgesics
iv. Heparin
v. Thromobolytic therapy.
Supportive treatment
i. Prevention of deep vein thrombosis
ii. Proper laxatives
iii. Liquid diet initially during attack
iv. Sedative to allay the anxiety
v. Treatment of complications like cardiac failure, arrhythmia, etc.
Percutaneous Transluminal Coronary Angioplasty (PTCA)
Surgical treatment
Coronary arterial bypass grafting (CABG).
Prevention and Control

WHO expert committee recommended the following strategies:
a. Population strategy
i. Prevention in whole populations
ii. Primordial prevention in whole populations.
b. High-risk strategy
c. Secondary prevention.
Population Strategy
Population strategy is based on mass approach focussing mainly on the
control of underlying causes (risk factors) in whole populations not merely
in individuals, small changes in risk factor levels in total population can
achieve the biggest reduction in mortality.
Specific Intervention
1. Dietary changes
a. Reduction of fat intake by 20 to 30 percent of total energy intake
b. Consumption of saturated fats must be limited to less than 10 percent
of total energy intake
c. A reduction of dietary cholesterol to below 100 mg per 1000 Kcal
per day
d. An increase in complex carbohydrate consumption.
2. Regular exercises and yoga practices
3. Hypertension and diabetes kept under control
4. Avoid undue stress
5. Avoid smoking and alcohol consumption.
Legislation
1. Banning the sale of cigarettes and alcohol
2. Making compulsory the printing of the statutory warning that smoking
and drinking alcohol is injurious to health
3. Banning the advertisement of cigarettes and alcohol.
Secondary Prevention
1. Early diagnosis
a. High-risk screening
b. Routine periodic investigation
2. Prompt and effective treatment.
Tertiary Prevention
1. Disability limitation
a. Balloon angioplasty and cardiac bypass surgery
b. Laser and ultrasonic destruction of clots
2. Rehabilitation
a. Physical rehabilitation
b. Occupational rehabilitation
c. Psychological rehabilitation.
HYPERTENSION
Hypertension is an iceberg disease, it has worldwide prevalence. Rules
of halves or 50 percent of the patients were aware of their state.
Fifty percent of those aware were taking treatment
Fifty percent of those being treated, were treated properly.
Prevalence
59.9 per 1000 In urban male population
69.9 per 1000 In urban female population
35.5 per 1000 In rural male population
35.9 per 1000 In rural female population
The sixth report of the Joint National Committee (JNC) on detection,
evaluation and treatment of high blood pressure, provides new guidelines
for hypertension control (Table 5.1).
Table 5.1: Classification of blood pressure for
adults aged 18 years and older *
Blood pressure, mm Hg
Category
Systolic diastolic
Optimal + < 120 and < 80
Normal < 130 and < 85
High-normal 130-139 or 85-89
2+
Hypertension
Stage 1 140-159 or 90-99
Stage 2 160-179 or 100-109
Stage 3 180 or 110
* When systolic and diastolic blood pressures fall into different category, should be selected
to classify the individuals blood pressure status.
+
Unusually low readings should be evaluated for clinical significance.
2+
Based on the average of two or more readings taken at each of two or more visits after an
initial screening
Risk Stratification
The risk of cardiovascular disease in patients with hypertension is
determined not by the level of blood pressure but also by the presence
of target organ damage (TOD), clinical cardiovascular disease (CCD) or
other risk factors such as smoking, dyslipidemia and diabetes. These
factors independently modify the risk of subsequent cardiovascular

disease. Based on the BP reading, the patients risk factors and presence
or absence of TOD/CCD, hypertensive patients have been stratified
into risk groups. The treatment to be initiated depends on the risk group
of the patient (Table 5.2).
Pharmacologic Treatment Initiation

The decision to initiate pharmacologic treatment requires consideration
of several factors: the degree of BP elevation, the presence of target
organ damage (TOD) and the presence of clinical cardiovascular disease
(CCD) or other risk factors (Flow chart 5.1 and Table 5.3).
Table 5.2: Risk stratification and treatment *
Blood pressure Risk group A Risk group B Risk group C
stages (mm Hg) (No risk factors; (At least 1 risk factor, (TOD/CCD
no TOD/CCD) 2+ not including and/or diabetes
diabetes, with or without
no TOD/CCD) other risk factors)
High normal Lifestyle Lifestyle Drug therapy
(130-139/85-89) modification modification
Stage 1 Lifestyle Lifestyle Drug therapy
(140-159/90-99) modification modification
(up to 12 months) (up to 12 months)
Stage 2 and 3
( 160/ 100) Drug therapy Drug therapy Drug therapy
* Major risk factors include smoking, dyslipidemia, diabetes mellitus, age > 60 years, sex (men
and postmenopausal women), family history of cardiovascular disease; and includes heart
diseases (left ventricular hypertrophy, angina or prior myocardial infarction, prior coronary
revascularization, heart failure), stroke or transient ischemic attack, nephropathy, peripheral
arterial disease, retinopathy.
2+
For patients with multiple risk factors, clinicians should consider initial drug therapy plus lifestyle
modifications.
For those with heart failure, renal insufficiency or diabetes.
Table 5.3: Concomitant condition and antihypertensive drug of choice

Concomitant condition Antihypertensive drug of choice
Angina -blockers, long-acting calcium antagonists
Postmyocardial -blockers, with intrinsic sympathomimetic activity,
infarction ACE inhibitors, verapamil/diltiazem ACE inhibitors in
conjunction with digoxin/diuretics, hydralazine plus isosorbide
dinitrate, carvedilol, losartan
Renal disease ACE inhibitors ACE inhibitor plus diuretic, loop diuretic,
loop diuretics plus long acting thiazide diuretic
Dyslipidemia -blockers
Diabetes mellitus ACE inhibitors, -blockers, calcium channel blockers,
diuretics (in low doses)
Elderly Thiazide diuretics -blockers plus thiazide diuretics,
long-acting calcium channel blockers
Flow chart 5.1: Algorithm for the treatment of hypertension
OBESITY
It is defined in terms of a body mass index (BMI) of 30 or more in male
and 28.6 or more in female indicate obesity.
Types
Hypertrophic obesityincrease in number of fat cell
Hyperplastic obesityincrease in size of fat cell.
Prevalence
In adulttwenty to forty percent.
In childrenten to twenty percent.
Epidemiological Factors
Age
It can occur at any age and generally increase with age. Infants with excessive
weight gain have an increased incidence of obesity in later life.
Sex
Men were found to gain more weight between the age of 29 and 35 years.
Women gain most between 45 and 49 years of age.
Socio-economic factors
Directly proportional to the per capita income.
Family tendency
1. Due to rich diet pattern
2. Overeating associated with pregnancy and lactation in well to do families.
Individual eating habits
1. Preference for energy rich diets in marked excess to the daily
requirement
2. Frequent eating
3. Alcohol consumption
4. Psychological overeating as a result of anxiety neurosis, depression, etc.
5. Junk food.
Physical exercise (enquire about)
1. Nature of job
2. Time devoted to sports or other physical activity
3. Recent illness particularly those which lead to long-term restriction
of physical activity, e.g. fractures.
Endocrine Disorders
1. Cushings syndrome
2. Cretinism and hypothyroidism
3. Pituitary disorders
4. Maturity onset diabetes mellitus
5. Insulinoma
6. Hypothalamic disorders.
Drug Intake
1. Corticosteroids
2. Estrogens.
Assessment of Obesity
Some indicators that are commonly used to measure obesity.
Brocas Index
The individual height in cms minus 100 = maximum permissible weight
of the individual in kg.
For example: For a person with a height of 182 cm. 182-100 = 82 kg is
the max permissible weight. Anything in excess of 82 kg will make the
person to be considered as obese.
Body Mass Index

Weight (in kg)
BMI =
[Height (in meters)]2
Males
1. Twenty to twenty-five desirable range
2. Twenty-two desirable ideal
3. Greater than 30 obese
Females
1. Nineteen to twenty four desirable range
2. Twenty one desirable ideal
3. Greater then 28.6 obese
Corpulence Index
Actual weight (in kg)
CI =
Desirable weight (in kg)
In obesity this should exceed 1.2.
Ponderal Index
Ht (in cms)
PI =
3 Wt (in kg)
Lorentzs Formula
[Ht in(cms) 150]
LF (Males) = [Ht (in cms) 100]
4
[Ht in(cms) 150]
LF (Females) = [Ht ( in cms) 100]
2
Fat Fold Thickness (Skin Fold Thickness)
The fat fold thickness is measured using skin callipers at the following
sites, mid triceps, biceps, subscapular and suprailiac region.
The sum total of the above measurements from all four sites should
not be more than 40 mm for adult males and 50 mm for adult females.
Normograms showing the ideal for males and females at various ages
are available.
Total Body Mass

The total body mass is also calculated by weight/volume studies using
water displacement technique.
Clinical Features of Obesity

1. Weight gain
2. Buffalo hump
3. Moon face
4. Prone to develop
a. Diabetes
b. Hyperlipidemia
c. Gallstones
Complications
1. Respiratory
a. Pickwickian syndrome
2. Cardiovascular
a. Hypertension
b. Cor pulmonale
c. Varicose veins
3. Gastrointestinal
a. Hiatus hernia
b. Fatty liver
c. Gallstones
4. Musculoskeletal
a. Osteoarthritis
b. Sciatica
c. Flat foot
5. Miscellaneous
a. Hernia
Treatment
1. Treatment of the secondary causes, like hypothyroidism, Cushings
syndrome, etc.
2. Diet:
a. Restrict the calorie intake.
b. Excessive eating should be avoided particularly at night.
c. Small and frequent meals should be preferred.
d. High roughage diet (which will have less calories) is preferred.
3. Exercise: It selectively decreases the body fat, while preserving the lean
body mass.
4. Behavior modification: It is advisable to treat abnormal patterns of
eating behavior.
5. Drugs:
a. Fenfluramine: 20 mg/day
b. Diethylpropion: 25 mg thrice a day
c. Biguanides
d. Thyroid extract
e. Amphetamine
6. Other methods:
a. Body massage
b. Steam-bath (sauna)
7. Surgery:
a. Gastric pouch by gastroplasty.
b. Jejunoileal shunt.
c. Gastric balloon: Balloon is introduced through gastroscope and
kept inflated, so that the patient gets a sense of satiety (feeling of
fullness) after a small feed.
d. Lipectomy: Removal of omental fat by laparotomy or liposuction.
Primordial Prevention
Avoidance of lifestyles leading to obesity and inculcation of habits for a
healthy lifestyle:
1. Dietary control
2. Physical exercises.
Identification of risk individuals:
1. Obese children
2. Those with familial tendencies and starting them on obesity manage-
ment regimes at an early age.
3. Treatment as outlined above.
Tertiary Prevention
1. Physical rehabilitation, e.g. physiotherapy.
2. Occupational rehabilitation.
RHEUMATIC HEART DISEASE

Rheumatic fever and rheumatic heart disease cannot be separated from
epidemiological point of view. The antecedent streptococcal pharyngitis
causes rheumatic fever that may lead to rheumatic heart disease. Once
heart disease is established, patient has to be treated surgically or by
other interventions and the financial burden increases.
Prevalence
Two per thousand population.
Epidemiological Factors
Agentgroup A streptococcus
Special emphasis is M type 5 which is frequently associated with
rheumatic fever.
Recently coxsackie B-4 has been suggested as a causative factor and
streptococcus acting as a conditioning agent.
Host and Environmental Factors

Age in 5 to 15 years
Sexboth sexes equally
Socioeconomic statuscommon in low socioeconomic status
Environmental factors:
Overcrowding
Poor housing conditions
Poor health care facilities (Particularly school health facilities).
Clinical Features
1. Fever
2. Polyarthritisin 90 percent cases in large joints
3. Carditisin 60 to 70 percent cases
4. Nodulessmall painless non-tender
5. Brainabnormal jerky purposeless movement
6. Skinvarious types of skin rashes.
Diagnosis
A WHO expert committee in 1988 has recommended use of revised Jones
criteria (Table 5.4) for diagnosis of acute rheumatic fever.
The presence of two major or one major and two minor manifestation
plus evidence of preceding streptococcal infection indicate high
probability of rheumatic.
Table 5.4: Jones criteria (revised) for
diagnosis of acute rheumatic fever
Major manifestations Minor manifestations
Carditis Clinical
Polyarthritis Fever
Chorea Arthralgia
Erythema marginatum Previous history of RF or RHD
Subcutaneous nodules Laboratory
Abnormal ESR
C-reactive protein
Leukocytosis
Prolonged P-R intervals

Primary Prevention
a. Health promotion: Health education regarding RF, RHD, to school
children, teachers and parents.
b. Specific protection (throat swab): If culture facility is not available, it is
justified to treat all sore throat with penicillin. For this purpose one
injection of penicillin containing 300,000 units of crystalline penicillin,
300,000 units procaine penicillin and 600,000 units benzathine penicillin
(available as one injection).
1. Early diagnosis
a. Surveillance of school children for RF and RHD
b. Throat swab for detection of group A Streptococci.
2. Prompt and effective treatment
a. Injection penidure 1.2 mega unit deep IM once in three weeks
b. Salt and water restriction and diuretics
c. Bed rest.
Tertiary Prevention
1. Disability limitation: Cardiac surgery
2. Rehabilitation, physical rehabilitation, occupational rehabilitation,
psychological rehabilitation.
MENTAL HEALTH
Mental health disorder is defined as a clinically significant behavior or
psychological syndrome or pattern that occurs in a person and that is
associated with a significantly increased risk of suffering death, pain,
disability or an important loss of freedom.
Prevalence
In India 18 to 20 per 1000.
Classification
1. Depressive disorders
2. Schizophrenia
3. Substance abuse disorders
4. Disorders of childhood and adolescence
5. Suicidal tendencies.
Etiology
1. Idiopathic
2. Organic condition
3. Sociopathological cause
4. Heredity.
Organic Conditions
Prenatal Causes
a. Chromosomal anomalies
i. Down syndrome
ii. Turners syndrome
b. Inborn errors of metabolism
i. Phenyl ketonuria
ii. Galactosemia
iii. Mucopolysaccharidoses
c. Cranial malformations
i. Microcephaly
ii. Hydrocephaly.
Perinatal Causes
a. Infections, e.g. TORCH
b. Physical causes
i. Birth trauma
ii. Radiation
c. Prematurity
d. Intoxications like bilirubin.
Postnatal Causes
a. Infections
i. Meningitis
ii. Encephalitis
b. Head injury
c. Malnutrition.
Social Pathological Causes

1. Worries
2. Anxieties
3. Stress
4. Broken home
5. Industrialization and urbanization.
1. Toxic substances
2. Psychotropic drugs
3. Radiation
4. Trauma.
Warning Signals of Poor Mental Health
1. Are you always worrying?
2. Are you unable to concentrate because of unrecognized reasons?
3. Are you continually unhappy without justified cause?
4. Do you lose your temper easily and often?
5. Are you troubled by regular insomnia?
6. Do you have wide fluctuations in your moods from depression to
elevation, back to depression, which incapacitate you?
7. Do you continually dislike to be with people?
8. Are you upset if the routine of your life is disturbed?
9. Do your children consistently get on your nerves?
10. Are you browned off and constantly bitter?
11. Are you afraid without real cause?
12. Are you always right and the other person always wrong?
13. Do you have numerous aches and pains for which no doctor can
find a physical cause?

Primary Prevention
Health promotion
a. Health education regarding causes and how to avoid some of them
b. Prospective genetic counseling
c. Marriage counseling
d. Specific prevention
e. Good quality of MCH care.
Early detection
Screening programs in schools, universities, and industry.
Prompt treatment
By using antipsychotic drugs.
Tertiary Prevention
Disability limitation
Rehabilitation
a. Specialized institution to impart care and training for the mentally
handicapped
b. Occupational therapy
c. Half-way homes and family service programs
d. Public education.
National Mental Health Program

The Government of India has launched the National Mental Health
program in 1982, keeping in view the heavy burden of mental illness in the
community, and the absolute inadequacy of mental health care
infrastructure in the country to deal with it (a total of about 20764 beds
available or 1 bed for 15400 population). Around 10 to 60 percent of the
OPD patients have mental illness which is usually mild in nature. In the
community the prevalence of mental illness range from 10 to 20 percent,
whereas severe type of mental illness is around 1 to 2 percent of the
population. The program envisages a primary health care approach in
the rural areas supported by professional psychiatric supervision from
the district level and referral services by the mental hospitals and mental
health units of the general hospitals.
Aims
1. Prevention and treatment of mental and neurological disorders and
their associated disabilities.
2. Use of mental health technology to improve general health services.
3. Application of mental health principles in total national development
to improve quality of life.
Objectives
1. To ensure availability and accessibility of minimum mental health care
for all in the foreseeable future, particularly to the most vulnerable
and under-privileged sections of population.
2. To encourage application of mental participation in the mental health
knowledge in general health care and in social development.
3. To promote community participation in the mental health services
development and to stimulate efforts towards self-help in the community.
Strategies
1. Diffusion of mental health skills to the periphery of the health services system:
Through the primary health centers which is the most extensive health
care system reach up to the most remote rural and tribal areas the
mental health can be provided. It requires the training of all level of
primary health care workers.
2. Appropriate appointment of tasks in the mental health care: The tasks to be
specified at all level of the health care delivery from village to District
health center.
DIABETES MELLITUS
Diabetes is an iceberg disease. The prevalence of diabetes mellitus in
adult is around 4 percent worldwide (1995), which will be 5.4 percent in
2025.
In India, 2.4 percent in rural, 4.0 to 11.6 percent in urban dwellers.
It is a one Potential Diabetic who has a risk of developing DM due
to genetic reasons (e.g. having a first degree relative with DM).
Latent Diabetic
It is a one who has risk of developing DM due to stressful conditions
like pregnancy, surgery, trauma, infections, etc. they may return to normal
if stress is removed.
Black Zone
It is a state of affairs in a Type 2 DM patients in whom blood glucose
levels are high but do not have symptoms, although the process of
complications is going on.
The factors that allow the patients to slip into the black zone are:
Lack of health services provided to diabetics
Lack of knowledge in the patient
(Or Defects in the health education program provided to diabetics)
Negligence by the patient (i.e. not accepting the presence of disease
and practicing a self-damage) behavior such as alcoholism.
Clinical Classification of Diabetes Mellitus as Adopted by WHO
1. Diabetes mellitus
a. Insulin-dependent diabetes mellitus
i. Juvenile diabetes mellitus
ii. Adult diabetes mellitus
b. Noninsulin dependent diabetes mellitus
c. Malnutrition-related diabetes mellitus
2. Impaired glucose tolerance
3. Gestational diabetes mellitus.
Epidemiology
Agent
1. Pancreatic disordersinflammatory, neoplastic, cystic fibrosis.
2. Defects in formation of insulin.
3. Decreased insulin sensitivity.
4. Autoimmunity.
Host
a. Ageany age
NIDDM usually at middle age group
b. Sexmale-female ratio is about equal
c. Genetic factor
d. Genetic markerHLA B8 and B15
e. Immune mechanisms
f. Obesity.
1. Sedentary lifestyle
2. Diet and alcoholism
3. Malnutrition
4. Viral infections (rubella, mumps, etc.)
5. Chemical agents
6. Stress.
Social Factors
a. Occupation
b. Marital status
c. Urbanization
d. Changes in lifestyle.
Clinical Features
1. Polyuria
2. Polydipsia
3. Polyphagia
4. Weight loss
5. Repeated infectionslike skin infections, urinary infections and others
6. Fatigue.
Complications
1. Diabetic ketoacidosis
2. Hyperosmolar hyperglycemic nonketotic coma
3. Latic acidosis
4. Diabetic retinopathy
5. Diabetic neuropathy
6. Nephropathy
7. Dermopathy
8. Fungal infections.
Investigations
1. Urine sugar and ketone bodies.
2. Fasting and postprandial blood sugar.
3. Glucose tolerance test (GTT) (Table 5.5).
4. Glycosylated hemoglobin.
Prevention and Care
High-risk Screening
Screening of the whole population is not a rewarding exercise. However,
screening of High-risk groups is appropriate.
These groups are:
Individuals above 30 years of age
Those with a strong family history of DM
Obese individuals
Sedentary workers with lack of exercise.
Other than high-risk group, the following group of persons should also
be screened for diabetes as a routine.
A patient with premature atherosclerosis
A person complaining polyurea, polyphagia, polydipsia sudden loss
of weight, repeated infections, nonhealing ulcer (purities vulvae in a
lady).
Patients undergoing surgery, including tooth extraction
All expectant mothers attending antenatal clinic
A pregnant mother gaining more than 3 kg body weight in any month
A woman who has given birth to a baby weighing more than 3.5 kg
at birth.
Primary Prevention
1. Population strategy
2. High-risk strategyavoid alcohol, smoking, oral contraceptives.
Table 5.5: Diagnostic values for the
oral glucose tolerance test (mg/dl)
Whole blood Plasma
Venous Capillary Venous Capillary
Diabetes mellitus
a. Fasting value 120 120 140 140
b. 2 hours after glucose load 180 200 200 200
Impaired glucose tolerance
a. Fasting value < 120 < 120 < 140 < 140
b. 2 hours after glucose load 120-180 140-200 140-200 160-200
1. Maintain blood glucose level
2. Maintain ideal body weight.
Treatment
It is based on:
1. Diet alonesmall balanced meals more frequently
2. Diet and oral antidiabetic drugs
3. Diet and insulin
4. Self-careadherence to diet and drug regimens, examination of his own
urine and blood glucose monitoring self-administration of insulin:
maintenance of optimum weight, estimation of glycosylated hemoglobin
at half yearly interval.
Tertiary Prevention
To prevent complication like:
1. Blindness
2. Kidney failure
3. Coronary thrombosis
4. Gangrene of the lower extremities.
National Diabetes Control Program
Government of India started National Diabetes Control Program on

pilot basis during 7th five year plan in 1987 in some districts of Tamil
Nadu, Jammu and Kashmir and Karnataka, but due to paucity of founds
in subsequent years this program could not be expanded further in
remaining years. However, a sum of 12 lakh during 1995-1996 was
allocated for the program. In 1997 to 1998, an allocation of 1 crore was made.
Objectives
1. Prevention of diabetes through identification of high-risk subjects and
early intervention in the form of health education.
2. Early diagnosis of diseases and appropriate treatment to reduce
morbidity and mortality with reference to high-risk group.
3. Prevention of acute and chronic metabolic, cardiovascular, renal and
ocular complications of the disease.
4. Provision of equal opportunity for physical attainment and scholastic
achievement for the diabetic patient.
5. Rehabilitation of those partially or totally handicapped diabetic people.
CANCER
Cancer is a major cause of death in India.
Prevalence
Cancer in all forms are causing about 12 percent of deaths throughout
the world.
In India, it is estimated there are approximately 2 to 2.5 million cases
of cancer in India at any given point of time with around 7,00,000 new
cases being detected each year nearly half of these dies each year
(Fig. 5.1).
Fig. 5.1: Cancer among Indians
Cancer registration: It provides a base for assessing the magnitude of

the problem and for planning the necessary services. There are two
types of registers (Flow charts 5.2 and 5.3).
Sex Differences
Ranking order by site of eight selected cancer.
Flow Chart. 5.2: Cancer registration
Flow chart 5.3: Cancer registration
CAUSES OF CANCER
Environment
Tobacco, Alcohol, Diet, Radiation, Occupation, Parasites, Viral infection
Ebstein Bar Virus (EBV), Cytomegalovirus (CMV).
Human Immunodeficiency (HIV), Human Papilloma Virus (HPV).
Genetic
Retinoblastoma, leukemia.
Primary Prevention
1. Avoid consumption of tobacco, alcohol
2. Diet control
3. Occupation, environmental (Protect from carcinogen)
4. Sunlight
5. Sexual reproductive factor
6. Control of air pollution
7. Treatment of precancerous lesions
8. Legislationto control known environmental carcinogens.
Health Education Regarding Danger Signals

1. A lump or hard area in the breast
2. A change in a wart or mole
3. A persistent change in digestive and bowel habits
4. A persistent cough and hoarseness
5. Excessive loss of blood at the monthly period or loss of blood outside
the exact date
6. Blood loss from any natural orifice
7. A swelling or sore that does not get better

8. Unexplained loss of weight.
Early detection of cases.
Treatment for Cancer

1. Chemical therapy
2. Radiotherapy
3. Surgical therapy
4. Palliative care.
NATIONAL CANCER CONTROL PROGRAM (NCCP)
Basic Steps
1. Assess magnitude of National cancer problem
2. Setting measurable cancer control objectives
3. Evaluating possible strategies
4. Choosing priority of action.
Goals of NCCP
1. To prevent future cancers
2. To diagnose cancer early
3. To provide curative therapy
4. To ensure freedom from suffering
5. To reach all in population.
District Cancer Control Program

1. Cancer education
2. Cancer screening camps
3. Ca cervixpap test
Carcinoma of Breast
1. Self-examination
2. Clinical
3. Thermography
4. Mammography.
Carcinoma of Lung
1. MMR
2. Sputum cytology.
BIBLIOGRAPHY
1. El Kholy A, et al. Bull WHO 1978;56:887.
2. Kishore J, National Health Programmes of India, 4th edn, 2002.
3. Mann JI, et al. Brit Med J 1976;2:445.
4. Parks Textbook of Preventive and Social Medicine, 16th edn, Nov 2000.
5. Seshubabu VVR, Review in Community Medicine. 2nd edn, 1996.
6. Shaper AG, et al. Brit Med J 1981;283:179.
7. Strasser T, et al. Bull WHO 1981;59:285-94.
8. The Sixth Report of the Joint National Committee on Prevention, Detection,
Evaluation and Treatment of High Blood Pressure. Arch. Intern Med 1997;
157:2413-44.
9. WHO. Sixth Report World Health Situation part I, 1980.
10. WHO. Techn Rep Ser, No. 695, 1983.
11. WHO. Techn Rep Ser 727, 1985.
12. WHO. Techn Rep Ser 764, 1988.
Maternity and Child Health 101
Chapter
6 Maternity and Child Health
CHAPTER OUTLINE
REPRODUCTIVE AND CHILD HEALTH PROGRAM MAJOR ELEMENTS OF RCH PROGRAM
ANTENATAL CARE MATERNAL AND CHILD HEALTH
INTRANATAL CARE POSTNATAL CARE
MALNUTRITION PROTEIN-ENERGY MALNUTRITION
BREASTFEEDING
In any community mother and children constitute a priority group. They

comprise 70 percent of population.
In India:
Women in reproductive age group constitute19 percent
Children under 15 years constitute40 percent
Total 59 percent population, but they are also a vulnerable or special
risk group.
In Developing Countries
One woman dies every minute.
190 women face unwanted or unplanned pregnancy every minute.
110 women face pregnancy complication.
40 women have unsafe abortion.
Causes of Maternal Death
Direct causes 80 percent
Indirect causes 20 percent
Direct Causes
Hemorrhage 25 percent
Sepsis 15 percent
Unsafe abortion 13 percent
Eclampsia 12 percent
Obstructed labor 8 percent
Other 7 percent
Indirect Causes
Anemia 23 percent
Viral hepatitis 20 percent as compared to 1 percent in non-
pregnancy
Malaria 30 to 35 percent
Tetanus 2 to 6 percent
HIV complications are more during pregnancy.
Conceptual Framework of Safe Motherhood

Four important aspects are to be considered equity, accessibility, affordability,
and accountability for quality care (Fig. 6.1).
Improvement of womens pre-pregnancy health is also important
(Table 6.1)
Fig. 6.1: Maternity emergency care
Risk Approach
The central purpose of antenatal care is to identify High-risk cases
from a large group of antenatal mothers.
1. Elderly primi (30 years and over)
2. Short statured primi (140 cm and below)
3. History of previous cesarean or instrumental delivery
4. Antepartam hemorrhage threatened abortion
5. Twinshydramnios
6. Pre-eclampsia and eclampsia
7. Previous stillbirth, intrauterine death, manual removal of placenta
8. Elderly grand multiparas
9. Prolonged pregnancy (14 days after expected date of delivery)
10. Anemia
11. Malpresentations, viz. breechs, transverse lie, etc.
12. Pregnancy-related general disease, viz. cardiovascular disease,
kidney disease, diabetes, tuberculosis, liver disease, etc.
Table 6.1: Milestones of Family Welfare Program
1880 Establishment of training for dais in Amritsar
1902 Ist Midwifery Act to promote safe delivery
1930 Setting up of Advisory Committee on Maternal Mortality
1951-56 1st Plan Family Planning Program adopted by Government of India,
first of its kind in the world
1961-66 3rd Plan Extension education approach
Department of Family Planning created in Ministry of Health
Created Target Oriented Approach
Lippes loop introduced
Contd...
Contd...
1969-74 4th Plan Family planning services under Primary Health Center
All India Hospital Postpartum Program
Medical Termination of Pregnancy (MTP) Act, 1971
1974-79 5th Plan Renaming Family Planning to Family Welfare
Community Involvement
Child Marriage Restraint Act 1978
1983 National Health Policy
1980-85 6th Plan Strengthening of Maternal and Child Health
Strengthening Family Welfare
1985-90 7th Plan Further inclusion of various programs under MCH
1992-97 8th Plan Child Survival and Safe Motherhood Program (CSSM)
1993-94 National Development Committee Report
International Conference on Population and Development
(ICPD), Cairo 1994
1996 Target Free Approach
Review of Safe Motherhood Component of CSSM
1997-02 9th Plan Reproductive and Child Health (RCH)
(CSSM plus STD and RTI components)
RTI = Reproductive Tract Infections)
REPRODUCTIVE AND CHILD HEALTH PROGRAM

The Reproductive and Child Health (RCH) Program for the Ninth Plan
is a very ambitious program which aims to effectively bring all the
reproductive and child health services within easy reach of the community.
Reproductive and Child Health Program marks a significant paradigm
shift in the India contexta change from a population control approach
through a top-down, target-driven program, to one that provides high
quality services that are gender-sensitive and responsive to the needs
of clients, especially women who are the major users but have a serious
problem of access, both physical and social to health services.
Definition of RCH
People have the ability to reproduce and regulate their fertility, women
are able to go through pregnancy and child birth safely, the outcome of
pregnancies is successful in terms of maternal and infant survival and
well being and couples are able to have sexual relations free of fear of
pregnancy and of contracting diseases.
Components of RCH (Fig. 6.2)
Fig. 6.2: Components of RCH

MAJOR ELEMENTS OF RCH PROGRAM

Reproductive Health Elements
1. Responsible and healthy sexual behavior
2. Intervention to promote safe motherhood
3. Prevention of unwanted pregnanciesincrease access to contraceptives
4. Safe abortion
5. Pregnancy and delivery services
6. Management of RTI/STD
7. Referral facilities by government/private sector for pregnant woman
at risk
8. Reproductive health services for adolescents
9. Screening and treatment of infertility, cancers and other gynecological
disorders.
Child Survival Elements

1. Essential newborn care
2. Prevention and management of vaccine preventable disease
3. Urban measles campaign
4. Neonatal tetanus elimination
5. Surveillance of vaccine preventable diseases
6. Cold chain system
7. Polio eradication: Pulse polio program
8. Acute respiratory infections (ARI) control program
9. Diarrhea control program and ORS program
10. Prevention and control of vitamin A deficiency among children
11. Baby Friendly Hospital Initiatives (BFHI).
State Committee on Voluntary Action

For RCH implementation and flow of funds, the states who have
established their ability for expenditure, utilization of funds and based
on their performance will be provided funds through State Finance
Department as at present. Otherwise, funds will be routed through a
State Committee on Voluntary Action (SCOVA), a registered society
with the State Chief Secretary as chairman and State Health Secretary
(FW) as vice-chairman. This will provide flexibility in fund utilization
on various activities like selection of contractual staff and experts.
Contents of Kits Supplied to Subcenter

and First Referral Unit (FRU)
Under the CSSM program supplies of drugs are being made to the sub-
centers. These kits are supplied twice a year. There are two types of
drug kits.
Drug kit A is supplied to all health workers while drug kit B is supplied
to health workers in selected areas of the country only.
These kits will reach once in six months. The PHC/district medical officer,
will have to ensure that the kits are supplied/distributed in turn to all health
workers and monitor the use of individual items in the kits.
Subcenter Drug Kits
(Twice a year to each subcenter)
Drug Kit A (For all districts under CSSM)
1. IFA (large) 15000 tablets
(100 mg)
2. IFA (small) 13000 tablets
(20 mg)
3. Vitamin A 6 bottles (100 ml each) (1 ml=1 lakh IU)
4. Cotrimoxazole 1000 tablets (pediatric)
5. ORS packets 150 packets
Drug Kit B (For selected districts)
1. Methylergometrine 500 tablets
(0.125 mgm)
2. Paracetamol 500 tablets
(500 mg)
3. Tablet antispasmodic 250 tablets
4. Methylergometrine 10 ampoule
(0.2 mg/ml)
5. Mebendazole 300 tablets
(100 mg)
6. Chloramphenicol 500 eye applicants
(1%)
7. Cetrimide powder 125 gms
8. Providone ointment 5 tubes (Iodine 5% tube of 25 gm each)
9. Cotton bandage 120 rolls (4 cm x 4 meter)
10. Cotton absorbent One roll (500 gm)
Under RCH Program

Health facilities that can function as FRUs get kit E to kit P. The different
types of kits are given below:
Kit E Laparotomy set
Kit F Mini-laparotomy set
Kit G IUD insertion set
Kit H Vasectomy set
Kit I Normal delivery set
Kit J Vaccum extraction set
Kit K Embryotomy set
Kit L Uterine evacuation set
Kit M Equipment for anesthesia
Kit N Neonatal resuscitation set
Kit O Equipment and reagents for blood test
Kit P Donor blood transfusion set
Methods to Estimate Requirements for MCH Services

Probable number of pregnancies = Population of area Birth rate of
the area.
Antenatal registration = Probable number of pregnancies + 10 percent
(for pregnancy wastage)
Fifteen percent of the antenatal women registered are high-risk
Fifty percent of the registered antenatal mothers are anemic
Ten percent of the live birth babies are sick or high-risk and need referral
services
Infants alive at one year in the area = number of live birthinfant mortality
rate of the area
Three percent of the total population is children below three years of age
Thirteen percent of the total population is children below five years
of age.
ANTENATAL CARE
Objectives of Antenatal Visit
1. Preventive services for mothers
2. Prenatal services
3. Prenatal advice
4. Specific protection
5. Mental health
6. Family planning
7. Pediatric care.
Prenatal Services
1. First visithistory, physical examination, investigation
2. Subsequent visitphysical examination, investigation
3. Distribution of iron and folic acid tablets
4. Immunization
5. Health education
6. Home visit
7. Referral services
8. High-risk approach
9. Maintenance of records.
Prenatal Advice
Prenatal advice regarding:
1. Diet
2. Personal hygienepersonal cleanliness, diet, rest, exercise, abstinence
from smoking and alcohol, dental care, sexual intercourse.
3. Drugs
4. Radiation
5. Warning signals:
a. Swelling of the feet b. Convulsions
c. Headache d. Blurring of vision
e. Bleeding and discharge per vagina f. Any other unusual symptom
6. Child care.
Specific Protection
1. Anemia
2. Nutritional deficiency disorder
3. Toxemia of pregnancy
4. Tetanus
5. Syphilis
6. German measles
7. Rh-Status
8. HIV infection
9. Prenatal genetic screening.
MATERNAL AND CHILD HEALTH
RCH-II and Family Planning

The RCH-II is the flagship program of the Government of India on
reproductive, child and maternal health under National Rural Health
Mission. The program has been reoriented and revitalized to give it a
pro-outcome and pro-poor focus.
Under RCH-II it is envisaged that 50 percent of PHCs and all CHCs
would be made operational as 24 hours delivary centers; in phased
manner; by the year 2010. These centers would be responsible for
providing basic emergency obstetric care and essential new born care
and basic newborn resuscitation services round the clock. Beside these
all the FRUs will also made operational for providing emergency obstetric
care by the end of RCH-II.
New areas-components and elements in RCH-II at various levels:
1. Village level: One Link worker or ASHA in each village.
2. Subcenter: Location; analysis of subcenter and necessary relocation
as per the need.
3. PHC: Location; analysis of PHC and necessary relocation as per the
need.
4. CHC: Ensure full staff; five specialists (OBG, pediatrics, anesthetiology,
general surgeon and physician) seven staff nurses, one pharmacist
and two laboratory technicians and one radiographer. Gradually 50
percent of CHCs should become first referral units (FRUs) for emergency
obstetric care.
5. District: The chief medical officer/civil surgeon will be provided

adequate training and knowledge of public health functions.
6. State: To build capacity in management (planning and decentralization
and management information and evaluation system).
Program Implementation Plan (PIP)

Differential approach for implementation of RCH-II program in
empowered action group (EAG) states based on the level of infant
mortality rate, institutional deliveries and strengthening of the health
system.
i. Integrated management of neonatal and childhood illness (IMNCI)
introduction in phased manner.
ii. Adolescent health initiative in selected districts (75 districts) for
adolescent friendly health services and counseling and once a week
clinic at PHC/CHC.
iii. Strengthening of social marketing of contraceptives in rural areas,
through rural health practitioners and community mobilization
through satisfied acceptor couples.
iv. Urban health: Provision of quality integrated primary health care
services to urban poor by establishing urban health center for
1:50,000 population with one medical officer, 3-4 ANMs, one
laboratory assistant, one public health nurse/lady health visitor,
one clerk and one chowkidar and a peon.
Second tier referral center it could be district hospital/maternity
home/private and NGO nursing home (by public private partnership).
v. Tribal health will be given primacy.
vi. Establishing newborn care corner in phased manner in the existing
FRUs/CHCs/PHCs/subcenters and priority will be given to EAG
states.
vii. Hospital generated waste management/infection control.
viii. Incorporation of new areas (adolescent health, urban primary
health care infrastructure, tribal health, adverse sex ratio in
different states, PNDT Act) in the matrix of priorities for behavior
change communication strategy (BCC).
ix. Revamping of training in RCH at various levels especially training
under newer areas incorporated under RCH-II.
Janani Suraksha Yojana
Promoting hospital delivery among poor families. It is 100 percent centrally
sponsored scheme to help all pregnant women (19 years and above)
from below poverty line families.
Janani Suraksha Yojana (JSY) has the main objectives of reducing
maternal and infant mortality by focusing on promoting institutional
delivery care during pregnancy, delivery and post-delivery by linking
delivery care to antenatal check-up and neonatal care along with

appropriate referral and transport assistance, in the BPL groups.
An Accredited Social Health Activist (ASHA) will be an effective link
between the field level Government machinery and the poor pregnant
women and they will make available the delivery services to the intended
beneficiaries, encouraging antenatal care, institutional delivery, adopting
small family norms. In addition, ASHA will escort the poor pregnant
women and also stay with the women during delivery.
Important Features of JSY
a. The scheme is 100 percent centrally sponsored and intended all
women from BPL families, of age 19 years or above. Benefit available
up to two live birth. In 10 low performing states (LPS) (namely; Bihar,
Chhattisgarh, Jharkhand, Orissa, UP, Uttarakhand, Rajasthan,
Madhya Pradesh, Assam and Jammu and Kashmir) the benefit will
be available for the woman on her own accord, chooses to undergo
sterilization, after the delivery.
b. Scale of Assistance
NB 1: LPS: Low performing States (10 states)
HPS: High Performing States (Remaining states/ UTs)
NB 2: Cash benefit of Rs. 500/- per live birth is to be given to all
pregnant women (BPL) after registration and at the time of delivery,
irrespective of the place of delivery.
NB 3: Such eligible beneficiaries under the scheme who deliver in
health institutions would get an additional cash benefit of Rs. 200/-
if they belong to rural areas and Rs. 100/- if they belong to urban
areas of ten low performing states (namely; Bihar, Chhattisgarh,
Jharkhand, Orissa, UP, Uttarakhand, Rajasthan, Madhya Pradesh,
Assam and Jammu and Kashmir).
c. The package for ASHA or an equivalent worker where ASHA has
not been recruited includes:
The referral transport assistance to go to the nearest health center,
The compensation for ASHA or an equivalent worker if she stays
with the pregnant woman in the health center for delivery.
d. Placement of imprest money with the ANMs: To quicken the process of
disbursement, all ANMs will be having an imprest of Rs. 5000/to
make all payment of cash assistance.
Note: Where Panchayati Raj Institutions (PRIs) exist and an elected body is in
place, the State Governments/District society will be at liberty to keep the money
with Panchayati Raj Institutions and empower Auxiliary jointly with the Gram
Panchayat through a simple procedures to recoup the imprest periodically. All
disbursements should be made immediately after delivery, if possible, in the
hospital itself.
e. Disbursement of cash assistance: As the scheme is targeting the poor
women who would generally be short of cash, it is essential that the
cash assistance provided under the scheme is made available to her
in the shortest possible time. With a view to quicken the process of
disbursement, ANM should keep a contingency amount of atleast

Rs. 1500/- with the ASHA or AWW (if ASHA has not been recruited)
and replenishment thereafter as already stated in the JSY guidelines.
f. Linking antenatal check-up, institutional delivery and neonatal care:
Beneficiaries should register themselves with the Health Workers
at the subcenter/primary health centers for availing of at least three
antenatal check-ups, postnatal care and neonatal care.
g. Encouraging pregnant women to undergo tubectomy/laparoscopy: If
hospitalization for delivery is followed immediately by tubectomy/
laparoscopy, the beneficiary will also get compensation money
available under the existing family welfare scheme.
h. Provision of cesarean section: Where government specialists are not
available, assistance up to Rs. 1500/- per case will be provided for
hiring services of private experts to carry out the surgery either in a
government medical facility or in private hospital, nursing home, etc.
i. Partnership with private sector: Benefits proposed under JSY would
also be available to such beneficiaries delivering in an accredited
private health institutions. Provision of five percent (4% for the district
authorities and 1% for the state) of the fund released towards
administrative expenses for monitoring, IEC and office expenses for
implementation.
Mamta SchemeAn Example of Public Private Partnership in

Health Care
India suffers from high maternal and neonatal mortality. One of the
reasons of this high mortality is home delivery conducted by untrained
personnel. In Delhi, approximately 3.2 lac deliveries take place every
year and 63 percent (as per NFHS 3 survey report, 2005) of these are
institutional deliveries and in some areas there are much lower rates of
institutional deliveries. Government of NCT of Delhi is committed to
provide equitable, quality health care for its citizens especially, the
maternal and child segment of its population. An important component
of health care aimed at reducing the maternal and infant mortality is
provision of Institutional Delivery for pregnant women. The
Government is trying to universalize institutional deliveries. However,
there are constraints like lack of adequate Government health facilities
equipped and functional to provide the comprehensive obstetric services
for the mother and the newborn and overburdened Government
hospitals. Therefore, PPP model was chosen wherein Private Hospitals
were approached to express their intention to join the Mamta scheme.
For comprehensive care, which includes antenatal Rs. 4000/- by the
district societies, however, these are part packages also, wherein for
institutional deliveries alone Rs. 3000/- is given. If only antenatal care is
provided Rs. 2000/-is given (Kishore and Charu, 2008).
Health Care Services for the Beneficiaries under the Scheme

1. At least three antenatal check-ups with all necessary investigations
including ultrasound of pregnant woman registered under the
scheme.
2. Provision of injection TT and iron folic acid tablets to all pregnant
women as per RCH schedule, provision of institutional delivery facilities,
including emergency obstetric care to all care to the newborn
including administration of birth doses of vaccines to newborns.
3. One postnatal check-up within first week of delivery but not later
than 14 days.
Eligibility Criteria for Beneficiaries under the Scheme
a. The pregnant woman must belong to the BPL/SC/ST category and
should be a resident of Delhi.
b. The pregnant woman should not be less than 19 years of age.
c. The pregnant woman should not have more than one living child.
Registration of Beneficiaries under the Scheme

The pregnant woman shall be enrolled under Mamta only after production
of the following documents:
a. Proof of age: Ration card/school certificate/birth certificate/affidavit/
any other relevant document/clinical assessment of the attending
doctor in absence of any other proof. Proof that she is a resident of
Delhi (Ration card/election I-card/any other document indication
specific address).
b. Affidavits regarding number of living children.
c. Registration of pregnant women will be preferably done in the first
trimester (12 weeks).
d. BPL card/certification of BPL status from the SDM/certificate of
SC/ST issued by competent authority.
Prevention of Patient to Child Transmission (PPTCT)

Prevention of Parent to Child Transmission of HIV Infection
When a child or infant is infected with HIV from an infected mother it is
known as vertical transmission and this can occur during pregnancy,
child birth and through breastfeeding. In general, the level of transmission
can vary in accordance with several variables, however, it is estimated
that 35 percent of the children of seropositive women can acquire HIV,
10 percent in pregnancy, 10 percent during the child birth and 15 percent
by breastfeeding.
In resource poor setting such as India the reported rate of mother-to-
child transmission ranges from 13-60 percent. According to Kumar et al
the vertical transmission rate in India is 48 percent. Another study
conducted by ARCON in Mumbai, Dongaonkar et al reported a mother

to child transmission rate of 36 percent.
1. All pregnant women attending the antenatal clinic are group
counseled and offered HIV testing. Those who opt to be tested
undergo pre-test counseling for HIV.
2. Testing is done as per NACO guidelines with 3 ELISA/Rapid test.
3. If the mother is found to be HIV positive, she is counseled after the
test. The post-test counseling focuses on disclosing the results of the
test, options to the mother with regard to breastfeeding of the child
and about HIV. Confidentiality is maintained.
4. The spouse of the HIV positive women is offered HIV counseling
and testing.
5. Nevirapine prophylaxis at the time of delivery is administered to
both the mother at the time of delivery and to the child immediately
after delivery, to reduce HIV transmission to the child.
Various Types of Antiretroviral Regimens

a. ShortShort course wherein the mother receives the ARV from 35
weeks of gestation and the infant for up to 3 days;
b. LongLong course wherein the ARV from 28 weeks of gestation
and the infant for up to 6 weeks;
c. ShortLong course wherein the ARV from 35 weeks of gestation
and the infant for up to 6 weeks;
d. LongShort course wherein the ARV from 28 weeks of gestation
and the infant for up to 3 days.
Role of maternal and child health services in the prevention of HIV
infection in infants and young children program.
Maternal and child health services:

PPTCT programs need to be integrated as an essential part of MCH
care. MCH care encompasses a broad range of educational and clinical
services that help mothers, their children and their families lead
healthy lives. Although, all four prongs of a comprehensive PPTCT
programs are important, antenatal care is the most common entry
point for women into those programs. MCH programs facilitate PPTCT
by providing:
Essential antenatal
Family planning services
ARV prophylaxis
Safe delivery practices
Counseling and support for the womans chosen infant feeding
method.
Integration of PPTCT within Postnatal MCH Services

Effective integration of PPTCT within postnatal MCH services is likely
to increase community acceptance of PPTCT programs and strengthen
maternal care, infant care and family care.
Maternal care: MCH postpartum care services help protect the mothers
health by providing medical and psychosocial care.
Infant care: MCH postnatal care services offer assessment of infant
growth and development, nutritional support services may include
ARV treatment.
Family care: MCH services provide social support, testing and
counseling for family members; referrals to community-based support
programs; and assistance in dealing with stigma.
Key Points
A comprehensive approach is needed to prevent HIV infection in
infants and young children
The four prongs of comprehensive care in PPTCT are:
Primary prevention of HIV-infection.
Prevention of unintended pregnancies in HIV-infected women
Prevention of HIV transmission from HIV-infected women to their
infants
Provision of treatment, care and support to HIV-infected women,
their infants and their families.
Without intervention the risk of MTCT is 25 to 49 percent
Combination interventions can reduce the MTCT rate by upto 40 percent
in breastfeeding populations.
Because ARV prophylaxis alone does not provide long-term benefit
to the mothers infection, ongoing care and support are needed.
MCH services can act as an entry point to the range of services that
can provide care and support to HIV-positive women and affected
family members.
Linkages to community services provide enhanced care support PPTCT
Services for the HIV-2 infected women. The HIV-2-infected women
should have access to the entire range of neonatal, labor and childbirth,
and postnatal services a linkages designed for HIV-1-infected women.
Offering the HIV-2-infected other short-course ARV prophylaxis to
prevent MCT should follow national and local policy, if such a policy
statement exits. The following information, adapted from the US
Centers Disease Control and Prevention (October 1998) provides
pertinent background on HIV for consideration:
HIV-2 infections are predominantly found in West Africa.
HIV-2 infections:
Have the same modes of transmission as HIV-1
Are associated with the similar opportunistic infections
Develop more slowly and appear less virulent than HIV-1

Appear to be less transmissible from mother to child than HIV-1.
Testing for both HIV-1 and HIV-2 should be considered in the following
situations:
When demographic or behavioral risk factors are present
When illnesses (such as opportunistic infections) appear in someone
whose HIV-1 test is negative
When an HIV-1 Western blot indicates certain indeterminate test
band patterns.
The best approach to clinical treatment of HIV-2 is unclear:
Not all drugs used to treat HIV-1 are as effective against HIV-2.
Treatment response is more difficult to monitor than in HIV-1;
CD4 + T-cell counts and physical sings of immune deterioration are
currently being used.
Non-nucleoside reverse transcriptase inhibitors, such as nevirapine,
are not effective against HIV-2; therefore, zidovudine therapy should
be considered for HIV-2-infected expectant mothers and their
newborn infants to reduce MTCT risk, especially for women who
become infected during pregnancy.
Womans wishes: The healthcare provider should have a frank
discussion with the HIV-2-infected woman to explain the prevailing
policy and practice and support her incoming to a decision with which
she is comfortable.
Continued surveillance to monitor the further spread of HIV-2 is
necessary.
Infant Feeding Formula (Table 6.2)

For infants from birth to six months old, modify animal milk to create
infant formula following these directions:
Table 6.2: Infant feeding formula
60 ml (One feeding for a 1-month-old infant)
Type of milk Milk Water Sugar
Cow, goat, or camel 40 ml 20 ml 4 g (1 teaspoon)
Sheep and buffalo 30 ml 30 ml 3 g (3/4 teaspoon)
90 ml (One feeding for a 2-month-old infant)
Sheep and buffalo 45 ml 45 ml 5 g (1 teaspoon)
120 ml (One feeding for a 3 to 4 -month-old infant)
Sheep and buffalo 6 g (1 teaspoon)
150 ml (One feeding for a 5 to 6 -month-old infant)
Sheep and buffalo 75 ml 75 ml 8 g (2 teaspoon)
INTRANATAL CARE
1. Thorough asepsis
2. Delivery with minimum injury to mother and child
3. Readiness to deal with complications such as prolonged labor, antepartum
hemorrhage, convulsion, mal-presentation, prolapse of cord, etc.
4. Care of the baby at delivery.
Care at Birth
Five Cleans
Clean hands, clean surface, clean cord tie, clean razor blade and clean cord
stump (no applicant).
POSTNATAL CARE
Care of the mother and baby after delivery.
Objectives of Postnatal Care

1. To prevent complications of postnatal period
Immediate Late
a. Puerperal sepsis Subinvolution
b. Thrombophlebitis Retroverted uterus
c. Secondary hemorrhage Prolapse uterus
d. Others Cervicitis
2. Restoration of mother to optimum health
a. Physical: Postnatal examination
i. Twice daily for three days
Once dailytill umbilical cord falls
Once in month up to six months
Once in two to three months up to 1 year
ii. Anemia correction
iii. Nutritional deficiency treatment
iv. Postnatal exercises to strengthen perineal muscles
b. Psychological: Eliminate anxiety, fear insecurity, Rx postpartum
psychosis if it occurs.
c. Social:
3. Breastfeeding
4. Family planning
5. Basic health education regardingpersonal hygiene, environment
hygiene, nutrition of mother and child, importance of health check-up,
spacing, birth registration.
Warm Chain
The warm chain is a set of ten interlinked procedures carried out at birth
and later, which will minimize the likelihood of hypothermia in all newborns.
The elements of warm chain are:
1. Warm delivery room (250C)
2. Warm resuscitation
3. Immediate drying
4. Skin-to-skin contact between baby and the mother
5. Breastfeeding
6. Postpone bathing
7. Appropriate clothing and bedding
8. Mother and baby nursed together
9. Warm transportation
10. Training and awareness raising of health care providers.
At risk infants: Identification of these neonates and giving special care is
important.
High-Risk Infants
1. Birth weight (1800-2500 gm)
2. Multiple births
3. Cesarean section
4. Suspected sepsis
5. At risk for isoimmunization
6. Born to mothers with previous bad obstetric history
7. At risk for hypoglycemia.
MALNUTRITION
Definition
Malnutrition has been defined as a state resulting from a relative or
absolute deficiency or excess of one or more essential nutrients.
Classification
1. Undernutrition
2. Overnutrition
3. Imbalance
4. Specific deficiency.
Children under 15 years of age are main victims.
Nutritional Problems (Table 6.3)

Table 6.3: Nutritional problems
Nutritional problem Prevalence
a. PEM By clinical examination 3% in (0-6 years
children)
By anthropometric 4% in (0-6 years children)
b. Vitamin A deficiency Conjuctival xerosis 5-10%
Corneal involvement 0.12% (in 0-6 years
children)
c. Anemia By Hb estimation 90% in pregnant women and
60% in 0-6 years children
d. Endemic Goiter Thyroid enlargement in 33% of the community
at risk.
Epidemiology
Conditioning Influences
1. Diarrhea
2. Intestinal parasites
3. Malaria
4. Measles
5. Whooping cough.
Cultural and Social Factors

Harmful cultural patterns and habits related to:
a. Breastfeeding
b. Weaning
c. Food taboos
d. Feeding of pregnant and lactating women
e. Repeated pregnancy.
Infections
a. Gastrointestinal infections
b. Worm infestation
c. Respiratory infection
d. Measles.
Health and Other Services

1. Nutritional surveillance
2. Nutritional rehabilitation
3. Nutritional supplementation
4. Health education.
PROTEIN-ENERGY MALNUTRITION
Definition
A range of pathological condition arising from deficiency of protein and
energy, normally associated with infection.
Protein-energy malnutrition (PEM) is major health problem and a
leading cause directly or indirectly of death during an emergency.
It is not only an important cause of childhood mortality and morbidity,
but also leads to permanent impairment of physical and possibly of mental
growth of those who survive.
Most commonly affecting children are between the age of six months
and five years.
The condition may result from lack of food or from infections that
causes loss of appetite while increasing the bodys nutrient requirements.
Children between 12 and 36 months old are especially at risk since
they are the most vulnerable to infections such as GIT infection and
measles.
Incidence of PEM in preschool age children is one to two percent.
Types of PEM
1. Marasmus
2. Kwashiorkor
3. Dwarfism (Subnormal physical development)
4. Marasmus-Kwashiorkor.
Marasmus
If deficiency arises early in the infancy marasmus is likely to supervene.
Marasmus is due to deficiency of protein and energy, characterized by
severe wasting of fat and muscle, which the body breaks down for energy
leaving skin and bones. This is most common form of PEM in nutritional
emergencies.
Nutritional marasmus is due to prolonged starvation.
Secondary marasmus is due to the result from chronic or recurrent
infection with marginal food intake.
Clinical Features
1. Low body weight for age
2. Loss of subcutaneous fat
3. One of the cardinal sign is muscle wasting [Signs(a) old man face,
(b) Baggy pants] (the loose skin of the buttocks hanging down).
4. No edema
5. Mental retardation
6. Infection.
In Kwashiorkor (Moonface)
In kwashiorkor, energy is adequate but lack of protein is the cause.
Kwashiorkor is mainly due to lack of protein (hypoalbuminemia).
Clinical Features
1. Low body weight
2. Muscle wasting
3. Dermatitis
4. Enlargement of liver
5. Changes in hair
6. Mental retardation
7. Infection
8. Edema.
Signs
Tick Sign
In kwashiorkor, if you start treatment edema start disappearing which
leads to weight loss, afterwards baby starts gaining weight, this sign is
known as tick sign.
Flag Sign
The hair is thin, dry, brittle, easily pluckable, sparse and devoid of their
normal shine. It becomes straight and hypopigmented.
The length of hair that grows during the period of nutritional deprivation
appears reddish brown, during phases of better nutrition, the growing
part of the hair gets appropriately pigmented. This gives appearance of
alternate bands of hypopigmented and normally pigmented hair.
Classification of PEM
Gomezs Classification (Weight for Age)
Normal 90-110
Grade I 75-89 percent
Grade II 60-74 percent
Grade III Less than 60 percent
Dr Udanis Classification (Calorie Deficiency Classification)

Grade I Twenty percent less than expected
Grade II Subcutaneous fat reduced in buttock
Grade III Subcutaneous fat reduced all over the body except cheeks
Grade IV Subcutaneous fat reduced all over the body including
cheeks.
Waterlows Classification defined Two Groups for PEM (Table 6.4)

Malnutrition with retarted growth, in which a drop in the height/age
ratio points to a chronic conditionshortness or stunted.
Malnutrition with a low weight for a normal height in which the weight
for height ratio is indicative of an acute condition of rapid weight
loss or wasting.
wt/ht = wt of the child/wt of the normal child at same height 100
ht/age = ht of the child/ht of normal child at same age 100
Table 6.4: Waterlows classification

Nutritional status Stunting (% of ht/age) Wasting (% of wt/ht)
Normal > 95 > 90
Mild impaired 87.5-95 80-90
Moderate impaired 80-87.5 70-80
Severly impaired < 80 < 70
Harwards Classification
Fifty percent Harward standard.
Arrange children of same birth date in ascending or descending order,
take 50th child as Indian standard.
Jellyfish Classification
Grade I 81-90% of the 50th Harward
Grade II 71-80% of the 50th Harward
Grade III 61-70% of the 50th Harward
Grade IV Less than 60% of the 50th Harward
NSIAP (National Subcommittee of Indian Academy of Pediatric)

Grade I 71-80% of 50th Harward
Grade II 61-70% of 50th Harward
Grade III 51-60% of 50th Harward
Grade IV Less than 50% of 50th Harward
Waterlows Classification
When child age is known, measurement of weight enables almost instant
monitoring of growth (Table 6.5).
Table 6.5: Measures of height assess the effect of
nutritional status on long-term growth
W/H > m-2D < m-2D
H/A
> m 2D Normal Stuntend
< m 2D Wasted Wasted and stunted
Epidemiology of Malnutrition
Poverty Cycle
Vicious Cycle
1.
2.
Agent Factor
1. Ignoranceof nutritional awareness in the country.
2. Inadequate dietin terms of quality and quantity.
3. Infectionmost common is diarrhea, ARI, measles, worm infestation
4. Weaninggradual withdrawal of the child from the breast of the
mother and introduction of supplimentary (semisolid) food.
Breast milk isbirth right of child

After four months breast milk alone is insufficient for development of
child.
Next choice is cows milk.
Beliefcustoms and habits
Misuse of antibiotics and self-medication.
Host Factors
1. Agefive years
Six months to two years most vulnerable group
2. Sexfemale children > vulnerable.
3. Birth orderchance of PEM increases with increasing birth order 1st
child > PEM
4. Family sizelarger the family size > PEM
5. Literacy statePEM is more in baby of illiterate mother
6. Socioeconomic statePEM > in low socioeconomic state
7. Knowledge Attitude Practice (KAP)regarding PEM
a. Cow dung application for umbilical cord
b. Brand marking if child weeps, suspecting for abdominal pain and
sometime purgatives are given
c. Postnatal mother kept in for one month with child in dark room.
d. Child is not put to breast during first three days of birth because of
belief that colostrum might be harmful. Instead child is put on sugar
solution and water.
Social Problems
A crucial role in the causation of PEM
1. Addiction in relation to alcohol
2. Reasons for smoking
3. Divorce and broken homes
4. Food habits and food fads
5. Cooking practicesopen cooking pan lose all nutrients
6. Food storage
7. Food habits of mother.
1. Poor housing
2. Inadequate water supply
3. Food production and availability
4. Infection and malnutritionagainst six killer diseases, i.e. DPT and
MTP (Measles, TB and Polio)
5. Economical statuspolitical will to improve economic status
6. Control of population explosion.
Examination of the Case

Hair : Luster, gray color, straight, easily pluckable
Face : Moon face in Kwashiorkor, pigmentation (due to specific
vitamin deficiency) old man face in marasmus
Eye : Anemia
Bitot spots
Conjunctivalxerosis
Cornealxerosis
Keratomalacia
Night blindness
Lips : Pigmentation, angular stomatitis
Tongue : Raw tongue, dry tongue pigmentation fissure
Teeth : Caries, mottled
Gum : Bleeding
Glands : Enlarged (inguinal glands)
Skin : Dermatitis
Flaky paint dermatitis
Nail : Koilonychia, brittle nail, bridged nail
Subcutaneous fatedema
Musculoskeletal systemwasting
Frontal and parietal bossing
Hepatomegaly
Mental confusion
Sensory loss
Calf tenderness
Body Measurement Techniques

Responsible personnel should be trained to measure and record weight,
height, and/or arm circumference as described in the following
paragraphs.
Weight
Weight should be measured to the nearest 100 g (0.1 kg). Although,
various types of scales are used for weighing infants in the field, the
most commonly used is the hanging spring balance scale, which can
weigh up to 25 kg.
Weighing Procedure (Fig. 6.3)

Note: If the parent or carer or other untrained person is acting as the
assistant, the measurer should carry out the weighing and record the
weight on the record form.
1. Measurer or assistant: Hang the scale from a tree branch, ceiling beam,
tripod, or pole held by two people, using a rope if necessary, so that
the scale is at eye level. Make sure that it is secure. Ask the parent or
carer to undress the child.
1. Put hands through leg holes

2. Grasp feet
3. Child hangs freely
4. Assistant with record form
5. Measurer reads scale at eye level
Fig. 6.3: Use of the hanging spring balance for weighing infants
2. Measurer: Attach a pair of weighing pants (or infant sling or basket)

to the hook of the scale and adjust the scale to zero; then remove the
pants.
3. Measurer: Put your arms through the leg holes of the weighing pants
(if used) while the parent or carer holds the child, grasp the childs
feet and pull his or her legs through the leg holes; make certain that
the strap of the pants is in front of the child.
4. Measurer: Attach the strap of the pants to the hook of the scale. Do
not carry the child by the strap alone. Gently lower the child and
allow him or her to hang free.
5. Assistant: Stand behind and to one side of the measurer ready to
record the weight (arrow 4). Have the record form and a pencil
ready to hand.
6. Measurer or assistant: Check the childs positionmake sure he or she
is hanging free and not touching anything.
7. Measurer: Hold the scale and read the weight to the nearest completed
0.1 kg call out the measurement when the child is still and the scale
needle has stopped moving; even the most active child will eventually
become still long enough for a reading to be taken.
8. Assistant: Immediately record the weight and show your record to
the measurer.
9. Measurer: Take hold of the child in one arm and gently lift him or
her; release the state from the hook of the scale with your free hand.
Do not lift the child by the strap of the weighing pants.
10. Measurer: Check the recorded weight on the form for accuracy and
eligibility. If there are any errors instruct the assistant to erase and
correct them.
Height or Length (Fig. 6.4)

Every effort should be made to measure childrens height or length
accurately, to the nearest 0.1 cm if possible. Measurement errors of 2 to
3 cm can easily occur and cause significant errors in classifying nutritional
status. Shoes and other footwear should be removed before measurements
are made.
Length
A child two years old or shorter than 80 cm (or 85 cm in a population
that is not chronically undernourished) should be measured lying
1. Record form and pen

2. Assistant on knees
3. Measurer on knees
4. Hands cupped over earshead against base of board
5. Arms comfortably straight
6. Line of sight perpendicular to base of board
7. Child flat on board
8. Hands on knees or shins legs straight
9. Feet flat against foot piece.
Fig. 6.4: Measuring a childs length
on its back. The child should be quiet, relaxed, and lying straight, with
the head resting against a fixed head-board; the childs should be looking
vertically upwards. The help of the childs parent or carer is often valuable.
Using one hand, the measurer should keep the legs straight by applying
gentle pressure to both knees of the child and ensure that the movable
slide is in contact with the surface of the soles and heels of the childs
feet (not just the toes).
Height (Fig. 6.5)

A child over two-years old (or taller than 80 or 85 cm) should normally
stand to be measured. The childs heels should be together, at the back
of the fixed foot-board. The buttocks, the backs of the heels, the upper
back, and the head should touch the measuring board, which should
have a metal tape-measure attached. The childs knees should not be
bent. The movable head-board, which must be horizontal, should be
1. Record form and pencil

2. Assistant on knees
3. Measurer on knees
4. Right hand on shins heels against back and base of board
5. Left hand on knees. Knees together and leg straight
8. Line of sight
9. Hand on chin
10. Shoulder level
11. Hands at side
6, 7, 12, 13, 14 Body flat against board
15. Head piece firmly on head.
Fig. 6.5: Measuring a childs height
slowly lowered until it rests firmly on the crown of the head (not just
lightly on the hair). The vertical tape-measure is read opposite the highest
point of the head when the child is looking straight ahead.
Midarm Circumference
Arm circumference is measured on the upper left arm. To locate the
correct point for measurement, the childs elbow is flexed to 90 degree,
with the palm facing upwards. A measuring tape is used to find the
midpoint between the end of the shoulder (acromion) and the tip of the
elbow (olecranon); this point should be marked. The arm is then allowed
to hang freely, palm towards the thigh, and the measuring tape is placed
snugly around the arm at the midpoint mark. The tape should not be
pulled too tight (Figs 6.6 and 6.7).
Fig. 6.6: Arm tapes
Fig. 6.7: These three children are being measured using an arm
tape. Which child is weak and thin?
Head and Chest Circumference

At birth the head circumference is about 34 cm. It is about 2 cm more
than the chest circumference. By six to nine months the two measurements
become equal, after which the chest circumference overtaken the head
circumference. In severely malnourished children, this overtaking may
be delayed by three to four years due to poor development of thoracic
cage. In a ICMR study, the crossing over of chest and head circumference
did not take place unitl the age of two years and six months, this has
been attributed to growth retardation in poor Indian children.
General Procedures
for Treatment of Severe PEM
1. Initial treatment phase
2. Rehabilitation phase.
Initial Treatment Phase

Initial treatment phase begins with admission to the therapeutic feeding
center and lasts until the child condition is stable and his or her appetite
has returned (Usually after 2-7 days).
Growth chart is a visible display of the childs physical growth and
development. The WHO prototype (home-based) chart is shown in
Figure 6.8. It has two reference curve. The upper reference curve
represents the median (50th percentile) for boys (slightly higher than
that for girls), and the lower reference curve the 3rd percentile for girls
(slightly lower than that for boys). Thus, the chart can be used for both
sexes. The space between two growth curve in Figure 6.8 has been called
the road-to-health.
Acute severe PEM is as much a medical emergency, as say a heart
attack even with utmost care, mortality rates are often 20 to 30 percent
or higher. Deaths commonly occur during the first 24 to 48 hours after
admission.
Complications
Commonly include:
1. Dehydration
2. Localized and generalized infection
3. Septic shock
4. Hypothermia
5. Hypoglycemia
6. Anemia
7. Vitamin A deficiency
8. Fluid and electrolyte imbalance.
Fig. 6.8: The WHO prototype growth chart

Preventive Measures
There is no simple solution to the problem of PEM. Many types of action
are necessary. The following is adopted from the 8th FAO/WHO expert
committee on nutrition for the prevention of PEM in the community.
Health Promotion
1. Measures are directed to pregnant and lactating women (education,
distribution of supplements like food, iron and folic acid tablets).
2. Promotion of breastfeeding
3. Development of low cost weaning foods, the child should be made to
eat food at frequent intervals.
4. Measures to improve family diet
5. Nutrition education promotion of correct feeding practices
6. Home economics
7. Family planning and spacing of births
8. Family environment.
Specific Protection
1. Childs diet must contain protein and energy rich foods, milk, eggs.
Fresh fruits should be given if possible
2. Immunization
3. Food fortification.
Early Diagnosis and Treatment

1. Periodic surveillance
2. Early diagnosis of any lag in growth
3. Early diagnosis and treatment of infection and diarrhea
4. Development of programs for early rehydration of children with
diarrhea
5. Development of supplementary feeding programs during epidemics
6. Deworming of heavily infested children.
Rehabilitation
1. Nutritional rehabilitation services
2. Hospital treatment
3. Follow-up care.
Calculation of Expected Weight of the Child

Age (months) + 9
For 3 to 12 months old child :
2
For 1 to 6 years of child : (Age in years 2) + 8
(Age in years 7) 5
For 6 to 12 years of child :
2
Calculation of Expected Height of the Child

At birth : 50 cm
At one year of age : 75 cm
For 2 to 12 years of age : (age in years 6) 77
Surface Area According to Weight

Range Surface area (meter2)
1-5 kg : (0.05 kg ) + 0.05
6-10 kg : (0.04 kg ) + 0.1
11-20 kg : (0.03 kg) + 0.2
20-40 kg : (0.02 kg) + 0.4
Calculation of Pediatrics Doses

Age
Youngs formula : Adult dose
Age + 12
Age
Dillings formula: Adult dose
20
BREASTFEEDING
A to Z Benefits for Baby

AAntibodies BBrain development
CColostrum DDigestion
EEasy FFresh
GGrowth promoting HHealthy
IImmunity factor JJoyful
KKnotting with baby LLoving
MMagnificent NNutrition
OObesity prevention PPromotes development
QQuantity unlimited RRecommended
SSatisfactory TTime tested
UUnique VValuable
WWhite blood XXenial
YYummy ZZephyr
Advantages to Mother
1. Feeling of motherhood
2. Reduces postpartum bleeding
3. Natural birth spacing method

4. Reduces risk of cancer
5. Economical
6. Reduces chances of osteoporosis
7. Helps to lose weight.
BIBLIOGRAPHY
1. Belavady B, Gopalan C. Indian J Med Res 1959;47:234.
2. Govt of India. RCH II and family planningprogram implementation plan
(PIP). New Delhi: Ministry of Health and Family Welfare, Govt of India:
2004.
3. Gopalan C, Kamala Jaya Rao. In: Prevention in childhood of health problem
in adult life F, Falkner (Ed), Geneva, WHO, 1980.
4. Govt of India, Reproductive and Child Health Service in Urban Areas.
Ministry of Health and Family Welfare, Nirman Bhawan, New Delhi.
5. Kohler KA, et al. Vaccine-associated paralytic poliomyelitis in India during
1999: decreased risk despite massive use of oral polio vaccine. Bull WHO
2002;80:210-6.
6. Lallemant M, Jourdain G, Le Couer S. A trial of shortend zidovudine regimens
to prevent mother to child transmission of human immunodeficiency
virus type 1. N Engl J Med 2000;343:982-91.
7. NFHS-3 IIPS, Mumbai, India, 2005-06.
9. Planning Commission. Tenth five year plan 2002-07. Vol II. New Delhi:
Planning Commission GOI;2002.
10. The Management of Nutrition in Major Emergencies. Authorized reprint.
WHO Geneva, 2002.
11. Venkatachalam PS, et al. Nutrition for Mother and Child, Spl Rep Ser, No
41, ICMR, New Delhi, 1971.
12. WHO. Risk Approach for MCH Care, WHO Offset Publication No. 39, 1978.
14. WHO. The Health Aspects of Food and Nutrition, A manual for developing
countries in the Western Pacific Region, 1979,p49.
16. WHO. The World Health Report 1996, Report of the Director General.
Chapter
Reproductive and
7 Child Health
CHAPTER OUTLINE
SUBCUTANEOUS DMPA AND HOME INJECTION
MANUAL VACUUM ASPIRATION (MVA)
CALCULATION OF THE EFFECTIVE COUPLE PROTECTION RATE (ECPR)
INTRODUCTION
Birth control services involve guidance about the timing, spacing and
number of children, education regarding contraceptive methods and
provision of facilities for the same, unless we understand the exact
technique of use, advantages and disadvantages. It is not possible to
motivate eligible couples to use them. Every doctor is expected to know
the use of contraceptives thoroughly.
Qualities of Good Contraceptives

The wide variety of contraceptives available today reflects the fact that
an ideal contraceptive is yet to be developed. The desirable qualities in
a good contraceptive are listed below.
1. Reliability 100 percent effectiveness
2. Safety Freed from associated side effect or complication
3. Reversibility Complete return to fertility when the method is
discontinued
4. Low cost
5. Convenience
6. Consumer control
7. Cultural acceptability.
Cafeteria Choice
That is to offer all methods from which an individual can choose
according to his needs and wishes and to promote family planning as a
way of life.
Conventional Contraceptive
Contraceptive is used to denote those methods that required action at
the time of intercourse, i.e. condoms, spermicides, etc.
Contraceptive Failure Rate (CFR) (Table 7.1)

It is calculated as:
Reproductive and Child Health 135
No. of accidental pregnancies 1200

CFR =
No. of patients observed months of use
Example: If 100 couples have used a method for a period of one year and
has resulted in 20 accidental pregnancies then the pregnancy rate
(contraceptive failure rate) would be:
20 1200 20
,
100 12 HWY
where HWY is hundred women years.
Table 7.1: Failure rate of contraceptives
Contraceptive Failure rate
methods (Pregnancies per
100 women years)
None used 80
Natural methods
Rhythm method 25
Withdrawal (coitus interruptus) 25
Barrier methods
Condom 10-14
Spermicidal 30
Douching 40
Dutch cap 4-6
Today (nanoxynol-9) 9-30
IUCD
Progestasert 0-3
Lippes loop 3
Copper-7 1.9
Cu-T-200 3.0
Cu-T-200c 0.9
Nova T 0.7
Multiload 250 0.5
Multiload 375 0.1
Oral pills
Postcoital:
Ethinyl estradiol 1-1.5
Stilbestrol 5 days 0-2.4
Combined (Mala N,D) 0.1
Minipills 2-3
Injected and implants
Depot (Medroxyprogesterone acetate) 1.0
Depot (Norethisterone Oenanthate) 0.6
Norplant 1.1
Silastic vaginal rings (SVR) 3.5
Centchromen 1.83
Sterilization
Mini-laparotomy (Pomeroys method) 0.4
(Madlener method) 7.0
Laparoscopic sterilization 0.6
Hysteroscopic sterilization 1.5
Pregnancy Rate
It is calculated as:
CFR = Twenty per hundred women years (HWY) of exposure.
(Do not forget to write the rate in terms of HWY or you will lose
valuable marks).
Methods of Family Planning (Flow chart 7.1)
Flow chart 7.1: Family planning methods
Newer Contraceptives
To expand choices for women, CuT 380A, a long-term intrauterine device
has been added in the National Family Welfare Program. This will
provide long-term (upto 10 years) protection for women and will be
useful for women who have completed their family size but do not want
to undergo for terminal methods (Table 7.2).
Table 7.2: A brief account of contraceptives
Method How it works Advantages Disadvantages

Low-dose When a woman swallows No need to do anything at the Some women have upset stomach
combined oral a pill each day, her ovaries stop time of sex. (especially in first 3 months) and/or
contraceptives releasing eggs. She cannot become Monthly periods are regular, light short; spotting or bleeding between
(the pill) pregnant without an egg. milder, fewer cramps. menstrual periods, missed periods,
Effectiveness: Very effective if Helps to prevent iron deficiency anemia, mild headaches, breast tenderness
taken every day. Effective as usually ectopic pregnancy ovarian and uterine and/or slight weight gain.
used. cancer, and pelvic inflammatory Some women cannot remember pill
No STD protection. disease (PID) a every day.
Also can be used for emergency In rare cases the pill causes stroke,
contraception heart attack, or clots deep in the
especially in woman with high leg
blood pressure and in woman who
smoke and also are 35 or older.
Condom A very thin, flexible sheath that covers Only method proved to prevent STDs, Must take the time to put condom
the mans erect penis during sex. including HIV/AIDS, and also on erect penis before sex.
It keeps sperm out of the womans pregnancy when used correctly May decrease sensation.
vagina. Also prevents many STDs with every act of sexual intercourse. May cause itching for a few people
from passing between sex partners. Helps prevent conditions caused by allergic to latex rubber.
Effectiveness: Effective if used STDs, such as pelvic inflammatory
correctly and every time. Only disease (PID) in women and infertility
somewhat effective as usually used*. in both women and men.
Best method for STD prevention. No need to see a health care provider
before using.
Contd...
Contd...
Female A specially trained health care A single procedure leads to effective, Usually painful for a few days after
sterilization provider makes a small surgical lifelong family planning. the procedure. Slight chance
opening in the womans abdomen Nothing to remember and no repeated if infection or bleeding at incision,
and closes off both tubes that carry clinic visits needed. internal infection or bleeding, or
eggs from the ovaries to the womb. No known long-term side effects injury to internal organs.
Then eggs cannot meet the mans or health risks. Usually not reversible.
sperm. The woman still has menstrual A woman can still have sex as usual.
periods.
Effectiveness: Very effective and
permanent. * No STD protection.
Vasectomy A specially trained health care A single quick procedure leads to Not effective at once. Couple must
provider makes a small surgical effective, lifelong family planning. use another method for at least the
opening in the mans scrotum (the A man can still ejaculate and have first 20 ejaculations or 3 months.
sac of skin that holds the testes) sex as usual. Usually some discomfort for a few
and closes off both tubes that carry No known long-term side effects of days after the procedure. Possibly
sperm from his testes. The man still health risks. also some pain, bruising in the
produces semen, but it has no sperm scrotum.
in it to make a women pregnant. Usually not reversible.
Effectiveness: Very effective and
permanent. * No STD protection.
Long-acting Injectables Depo-Provera (DMPA) Private. No one else can tell that the Changes in menstrual bleeding are
injectable and Norethisteron enanate (NET EN) woman is using contraception. normalsuch as light spotting at
contraceptives stop ovaries from releasing eggs. A Long-term yet reversible. Each injection first and no periods after the first
woman cannot become pregnant lasts at least 3 months (DMPA) or 2 year of use. (Some women
without an egg. They also thicken months (NET EN). The woman has consider no periods an advantage).
cervical mucus so sperm cannot pass. to remember only to return for next Some women gain some weight.
Effectiveness: Very effective when injection. (Some women consider this an
Contd...
Contd...
spaced 3 months apart (for DPMA) or advantage).
2 months apart ( for NET EN )*.
Norplant implants Small plastic capsules placed under Lasts at least 5 years; fertility returns Changes in menstrual bleeding
the skin of a womans arm slowly when capsules are taken out. are normalespecially spotting or
release a hormone. The hormone Nothing to remember. No need to do bleeding between periods. Some
thickness cervical mucus so sperm anything at the time of sex. women have no periods. (Some
cannot pass. Sometimes also stops Helps prevent iron deficiency anemia women consider no periods an
ovaries from releasing eggs. and ectopic pregnancy. advantage).
Effectiveness: Very effective. Clinic procedure needed to start or
*No STD protection. stop use.
Intrauterine device A small, flexible plastic frame, often Effective prevention of pregnancy for Many women at first have longer,
(IUD) with copper wire or sleeves on it. as long as 10 years; fertility returns heavier menstrual periods, bleeding
A health care provider inserts the when IUD is taken out. or spotting between periods, or more
IUD into the womans womb through No need to do anything at the time of menstrual cramps or pain.
her vagina. The IUD stops egg and sex. Can be inserted just after childbirth. Clinic procedure needed to start or
sperm from meeting. stop use.
Effectiveness: Very effective. Pelvic inflammatory disease is more
*No STD protection. likely to follow STD infection if a
woman is using an IUD.
Fertility awareness A woman learns to recognize the No physical side effects. More effective methods take 2 or 3
based methods fertile time of her menstrual cycle. Very little or no cost. months to learn. Calendar method
(Including periodic To prevent pregnancy, a couple Most couples can use these takes 6 months of recording
Contd...
Contd...
abstinence) avoids vaginal sex during the fertile methods if committed to them. cycle length before it can be used.
time or else uses a barrier method or Acceptable to some religious Long abstinence may cause tension.
withdrawal. groups that objects to other Some methods may be less reliable
Effectiveness: Effective if used or more difficult to use if woman is
correctly. Only somewhat effective as sick, has a vaginal infection, or is
usually. breast-feeding.
*No STD protection
Vaginal methods A woman places a spermicide, or Womancontrolled method for use May cause irritation. Can make
(Spermicides, else a diaphragm or cap with when needed. urinary tract infections more
diaphragm, spermicide, in her vagina before sex. May help prevent some STDs and common.
cervical cap) Spermicides kill sperm or stop their conditions caused by STDs. Possibly Woman must put method in vagina
movement. some protection against HIV/AIDS, before every act of sexual
Diaphragms and caps keep sperm but this is not proved. intercourse.
out of the womb. No need to see a health care provider
Effectiveness: Effective if used before using spermicides.
correctly and every time. Only
somewhat effective as usually used.
* Help prevent STDs.
What to do if you miss one or more pills (Flow chart 7.2)
Flow chart 7.2: Every time you miss one or more active pills (days 1-21:)
Anti-fertility Vaccines
Under development.
1. Anti-hCG Vaccines subunit of hCG linked chemically to a carrier
protein.
2. Immunization of female using specific antigen-Zona pellucida,
trophoblastic surface antigen, sperm-inhibine antigen.
3. Anti GnRH VaccineHocks LHRH activity prevents spermatogenesis/
ovulation.
No Scalpel Vasectomy
It is an improvement on the conventional vasectomy as it is safe,
convenient and more acceptable to male. In this operation the pair of
scissors is used to pierce the skin and through small opening the vas is
tied and cut. No stitch is required. This new method is being offered to
men, who have completed their families on a voluntary basis.
Emergency Contraceptives
Experience gained from clinic-based trials is not adequate from the point
of program operations. Without careful planning and preparation, the new

methods may be poorly accepted and the dropout and pregnancy rates
may be unacceptably high. It also damages the reputation of family
planning program. Emergency contraceptives are as follows:
1. High-dose estrogen in a dose of 5 mg daily for 5 days
2. Estrogen-progesterone combination:
a. Yuzpe method: EE 50 g + LNG 250 g of 2 pills given as soon as
possible after unprotected coitus and repeat after 12 hours
b. EE 30 g + LNG 150 mg of 4 pills are taken as soon as possible
after unprotected coitus and 4 more pills after 12 hours
c. EE 200 g + dl norgestrel 2 mg or 1 mg/LNG 1 mg of one pill as
the first dose followed by another pill after 12 hours.
3. Progesterone-only pill: LNG 0.75 mg as soon as possible after
unprotected sex followed by another pill 12 hours later
4. Antiprogesterone-mifepriston (RU-486) in 600 mg single dose
5. Intrauterine contraceptives (IUD) insertion within 5 days of unprotected
sex
6. Danazol
7. GnRH antagonist
EE = ethinyl estradiol
LNG = levonorgestrel
Emerging Oral Contraception

Emergency oral contraception can prevent pregnancy. It is also called as
postcoital or morning after contraception. Any women can use
emergency oral contraception if she is not already pregnant.
Emerging oral contraception should be started up to 72 hours after
unprotected sex.
It mainly stops ovulation but perhaps also works in other ways. It
does not disrupt existing pregnancy. It seems to prevent at least three-
fourths of pregnancies that would otherwise have occurred. (Average
chance of pregnancy due to one act of unprotected intercourse in the
second or third week of the menstrual cycle is 8 percent; after emergency
oral contraception1-2%). The sooner emergency oral contraceptive are
used, the better they prevent pregnancy.
Emergency oral contraception should not be used in place of family
planning methods. It should be used only in an emergency for example:
A woman has had sex against her will or has been forced to have sex
(rape).
A condom has broken.
An IUD has come out of place.
A woman has run out of oral contraceptives, has missed 2 or more
progestin only oral contraceptives, or is more than a few weeks late
for a DMPA injection and has had sex without using other family
planning.
Sex took place without contraception, and woman wants to avoid

pregnancy.
Emergency oral contraception does not prevent sexually transmitted
diseases.
Give Specific Instructions

1. Upto 72 hours after unprotected sex, the woman should take 4 low
dose or 2 standard dose combined oral contraceptives, or else
take 20 or 25 progestin contraceptives, and then take another equal
dose 12 hours later.
Important: If she takes pills from a 28 days packet of combined oral
contraceptives, she must be sure to take hormone-containing pills.
Show her which pills contain hormones.
2. If willing, she should start another method immediately, such as
condoms and/or spermicide, or she should avoid sex until she can
start her preferred methods.
Progestin-only pills better for emergency contraception.
A large WHO study has found that progestin-only pills are better
than combined oral contraceptives (progestin + estrogen) for emergency
contraception. Used for emergency contraception, progestin only pills
were more effective and caused less nausea and less vomiting.
Dosage: Either 20 or 25 progestin-only oral contraceptive tablets up to
72 hours after unprotected sex. Then 20 or 25 more tablets 12 hours
later.
Note: Special-purpose pills, each containing 0.75 milligrams
levonorgestrel may be available in some places.
Table 7.3 tells us how many pills to take according to their formulation:
Table 7.3: Pills and their formulation

Formulation (Examples of brands) Number of pills Number of pills
to swallow within to swallow
72 hours 12 hours later
Progestin-only oral contraceptive containing 20 20
0.075 milligrams (75 micrograms) of
norgestrel (Ovrette, Neogest, Norgeal)
Progestin-only contraceptives containing 25 25
0.03 milligrams (30 micrograms) of
levonorgestrel (Follicle, Microval, Microlut,
Microluton, Mikro30 Wyeth,
Mikro-30, Norgestin, Nortel).
Low dose COCs containing 0.15 or 4 4
0.25 milligrams of levonorgestrel or
0.5 milligrams of norgestrel plus
0.03 milligrams (30 micrograms) of ethinyl
Contd...
Contd...
Formulation (Examples of brands) Number of pills Number of pills
to swallow within to swallow
72 hours 12 hours later
estradiol (Lo-feminal, Lo-ovral, MalaD (India),
Nordette, Microgynon-30)
Standard-dose COCs containing 0.125 or 2 2
0.25 milligrams of levonorgestrel or 0.5 milligrams
of norgestrel plus 0.05 milligrams (50 micrograms)
of ethinyl estradiol (Eugynon 50, Nordiol, Ovral,
Microgynon 50, Nordette 50)
Levonorgestrel 0.75 mg (Postinor 2) 1 1
COC = Combined oral contraceptive
Important
Other combined oral contraceptive pills may work too but their effectiveness
for emergency contraception has not been tested. (Note that equal weights
of different hormones do not mean equal strength).
Give Advice on Common Problems

Nausea: Suggest that she eat something soon after taking the pills to
reduce any nausea. Prescription anti-nausea medicines such as
Dramamine and Marezine can reduce the risk of nausea when taken
half hour before taking emergency contraceptive pills and every four
to six hours thereafter.
Vomiting: If the woman vomits within two hours after taking the
pills, she need to take another dose. Otherwise, she should not take
any extra pills. Extra pills will not make the method more effective
and they may increase nausea. If vomiting continues, she can repeat
dose by vaginal replacement.
Her next monthly period may start a few days earlier or later than
expected. Reassure her that this is not a bad sign.
Explain Specific Reasons to Return to the Health Care Provider

1. Advise her to return or see another health care provider if her next
period is quite different from unusual for her, especially if it is:
Unusual light (possible pregnancy).
Dose not starts within four weeks (possible pregnancy).
Unusually painful (possible ectopic pregnancy. But emergency oral
contraception does not cause ectopic pregnancy).
2. Describe the symptoms of sexually transmitted diseases, for example,
unusual vaginal discharge, pain or burning on urination. Advise her
to see a health care provider if any of these symptoms occur.
Introduction to Injectable Contraceptives

Depot-medroxyprogesterone acetate (DMPA) is given every three
months. It contains a progestin, similar to the natural hormone that
a womans body makes. The hormone is released slowly into
bloodstream also known as depot-medroxyprogesterone acetate,
Depo-proverai, Depo and Mejestron.
There are other injectable contraceptives. NET EN-also called
Noristrat, norethindrone enanthate and norethisterone enanthate is
given every two months.
Mechanism of Action
Mainly stops ovulation (release of eggs from ovaries).
Also thickens cervical mucus, making it difficulty for sperm to pass
through.
DMPA does not work by disrupting existing pregnancy. Failure rate
0.3 pregnancies per women in first year of use (1 in every 333) when
injections are regularly spaced three months apart. Pregnancy rates may
be higher for women who are late for injection or who miss an injection
if provider runs out of supplies.
Advantages and Disadvantages of Injectable Contraceptives
Advantages
Very effective
Private. No one else can tell that a women is using it.
Long-term pregnancy prevention but reversible. One injection
prevents pregnancy for at least three months.
Does not interfere with sex.
Increased sexual enjoyment because no need to worry about
pregnancy.
No daily pill taking.
Allows some flexibility in return visits. Client can return as much as
two week early or weeks late for next injection.
Can be used at any age.
Quantity and quality of breast milk do not seem to be harmed. Can
be used by nursing mothers as soon as six weeks after childbirth.
No estrogen side effect. Does not increase the risk of estrogen related
complications such as heart attack.
DMPA prevents ectopic pregnancies in user
DMPA prevents endometrial cancer in user
DMPA prevents uterine fibroids in user
DMPA help prevents ovarian cancer in user.
Special advantages for some women:

May help in preventing iron deficiency anemia.
May make seizures less frequent in women with epilepsy.
Makes sickle cell crisis less frequent and less painful.
Disadvantages
Common side effects (not sign of sickness)
Changes in menstrual bleeding are likely including:
Light spotting or bleeding. Most common at first.
Heavy bleeding can occur at first but rare
Some women will have amenorrhea, especially after first year of
use. It may cause weight gain (average of 1-2 kilo or 2-4 lbs each
year). Some women see weight gain as advantage.
Delayed return of fertility (until DMPA levels in the body drop).
About four months longer wait before pregnancy than for women
who had been using combined oral contraceptives, IUDs, condoms
or a vaginal method.
Requires another injection every three months.
May cause headaches, breast tenderness, moodiness, nausea, hair
loss, less sex drive and/or acne in some women.
Does not protect against sexually transmitted diseases including HIV/
AIDS. Table formulations, injection schedules and availability of
injectable contraceptives are given in Table 7.4.
Table 7.4: Injection schedules and availability of injectable contraceptives
Common trade names Formulation Injection type and schedule

Progestin-only injectables
Depo-provera, Depot One intramuscular (IM)
Mejestron, contracep, medroxyprogesterone injection every three
Depo-prodasone acetate (DMPA) 150 mg months
Depo-sub provera DMPA 140 mg One subcutaneous
140 (DMPA SC) injection every
three months
Noristrat, Norigest, Norethisterone enanthate One IM injection every
Doryx (NET- EN) 200 mg two months
Combined injectables (progestin + estrogen)
Cyclofem, Medroxyprogesterone One IM injection every
Ciclofeminina, Lunelle scetate 25 mg + month
Estradiol cypionate
5 mg (MPA/E2V)
Deladroxate, Perlutal, Dihydroxyprogesterone One IM injection every
Topasel, Patectro, (algestone) month
Nomagest acetophenide 150 mg+
Estradiol enanthate 10 mg
Anafortan, Yectames Dihydroxyprogesterone One IM injection every
(algestone) month
acetophenide 75 mg +
Estradiol enanthate 5 mg
SUBCUTANEOUS DMPA AND HOME INJECTION

A new lower dose formulation of DMPA, depo-subQ provera 104 (also
called DMPA-SC) is injected under the skin rather than in the muscle. It
contains 104 mg of DMPA rather than the 150 mg in the intramuscular
formulation. Like the intramuscular formulation, DMPA-SC is given at
three months intervals.
Approved first in the United States and the United Kingdom,
subcutaneous injection of DMPA may be available in some developing
countries by 2008. DMPA-SC is available only in prefilled, single use
syringes. In developing countries it will be available only in prefilled
Uniject devices designed as the formulation for subcutaneous injection.
DMPA-SC is just as effective as the formulation injected into the muscle
and the patterns of bleeding changes and amount of weight gain are
similar. One year continuation rates in clinical trails were high, 68 percent
on average at sites in North and South America and 80 percent in Europe
and Asia. Despite the lower dose, DMPA-SC is effective for over weight
or obese women.
Injections of DMPA-SC are given in the upper thigh or abdomen. DMPA-
SC should not be injected intramuscularly and intramuscular formulation
should not be injected subcutaneously. The intramuscular formulation
cannot be diluted to make the lower dose subcutaneous formulation.
Injectables work mainly by preventing the development and release
of eggs from the ovaries (ovulation). They also thicken cervical mucus,
which blocks sperm from meeting the egg. Both progestin-only and
combined injectables are very effective when users return on time for
their next injections.
Long-term studies of the health risks and benefits are under way, but
few results are available yet. Still combined injectable contraceptives
contain the same types of hormones as combined oral contraceptives
(COCs). Therefore researchers assume that most of the findings about
COCs also apply to combined injectables. A difference is that monthly
injectables are not processed by liver before entering the bloodstreams,
as are medication taken by mouth. As a result, monthly injectable have
less effect.
Centchroman
This oral contraceptive does not contain any steroidal hormones,
developed by the Central Drug Research Laboratory, Lucknow. It is
marked under the brand names Saheli and Centron. It is taken twice
weekly for intial two months and thereafter once a week and has no
known side effects, except that in about 8 percent of users there is delay
in menses. It is advised to use barrier method for the initial two months
of start. Fertility typically returns within six months of discontinuation
of Centchroman. However 80 percent of the women do not know about
them (Vatsayan A et al, 1996).
Family Planning Insurance Scheme

Government of India is introducing a Family Planning Insurance Scheme
for acceptors of sterilization and indemnity cover for doctors performing
sterilization procedures in both government and private/NGO/
corporate health facilities. The insurance scheme will be operated by the
Oriental Insurance Company Ltd. (OCIL). The insurance scheme is as
follows:
Section I:
1. Death due to sterilization in hospital Rs.1,00,000
2. Death due to sterilization within 30 days of discharge from hospital
Rs. 30,000
3. Failure of sterilization (including first insurance of conception after
sterilization) Rs. 20,000
4. Medical complication occurring within 60 days of sterilization
operation Rs. 20,000
*To be reimbursed on the basis of actual expenditure incurred, not
exceeding Rs. 20,000.
Section II:
All the doctors/health facilities including doctors/health facilities of
central, state, local-self governments, other public sectors and all
accredited doctors/health facilities of non-governmental and private
sectors rendering Family planning services, conducting such operations
shall stand identified against the claims arising out of failure of
sterilization, death or medical complication resulting there from up to a
maximum amount of Rs. 2 lakhs per doctor/health facility in court, which
would be borne by the insurance company within certain limits.
All persons undergoing sterilization operation in public health facility/
accredited health facility in private/NGO sector are covered under
section I of the policy. The consent form filled by the person at the time
of enrolling himself/herself for sterilization operation shall be proof of
coverage under the scheme.
The scheme is uniformly applicable for all States/Union territories.
Government of India has paid entire premium for Insurance policy. States
do not have any expenditure under this scheme.
The claim settlements has been decentralized at state and District
levels and nominated officers of third party administrators (TPAs) will
co-ordinate with existing machinery of the States/UTs.
The present scheme will do away with the complicated process of
payment of ex-gratia to the acceptors of sterilization for the treatment
of postoperative complications, medical complications or deaths
attributed to the procedure of sterilization or deaths resulting from

sterilization but would also provide indemnity cover to the Doctor/
health facility affirming sterilization procedure.
Medical Methods of Abortion

Medical abortion methods are especially effective in the first trimester,
most effective before 49 days of pregnancy. This is due to the fact that
both Mifepristone and Methotrexate cause detachment of the trophoblast
(outer layer of developing embryo which ultimately forms the placenta)
from the uterine wall, which is easier to accomplish the less developed
the pregnancy.
Mifepristone and Misoprostol

Mifepristone (aka RU486) is more effective, earlier in the pregnancy it is
used: women with pregnancy durations of seven weeks or less LMP
experience a complete abortion about 95 percent of the time. Success
rates decrease to about 80 percent in the ninth week LMP.Mifepristone
acts primarily as an anti-progestational agent. The progesterone receptors
in the endometrium are blocked, and the disruption of the embryo and
trophoblast lead to a decrease in human chorionic gonadotropin (hCG)
produced by the placental tissues and therefore a withdrawal of hormonal
support for the corpus luteum. This provides the rationale for why this
method is more effective the earlier the pregnancy, because the more
dependent the pregnancy is on progesterone produced by the corpus
luteum, the more likely the action of the progesterone antagonist,
mifepristone, will result in abortion. The regimen involves three visits
to an abortion provider. On the first visit, the woman takes 600 mg
mifepristone orally. She returns two days later for administration of
Misoprostol, a prostaglandin which serves to soften and open the cervix
and cause contractions of the uterus, expelling the contents of the
pregnancy. In five percent of pregnancy, mifepristone alone is enough
to induce abortion, but in all other cases 400 to 800 ug of misoprostol is
administered orally or vaginally. Following administration of
misoprostol, three-fourths experience expulsion within 24 hours and
80 to 95 percent abort within two weeks. The third visit is for follow-up.
Side Effects
Most of the side effects when using this early abortion option are caused
by the second medication, misoprostol. Side-effects may include heavy
bleeding, headache, nausea, vomiting, diarrhea, and heavy cramping.
Criteria
Abortion medication may be an option if you:
Are less than eight weeks since your last menstrual period.
Are willing and able to give informed consent.
Have the support you need such as access to reliable transportation
and ability to communicate with the clinic by telephone.
Live no more than two hours away from emergency medical care
(a hospital).
Are able to come back to the clinic for one to three follow-up
appointments.
Agree to have a surgical abortion if the misoprostol does not induce
termination.
Contraindications
Blood clotting problem or women on anticoagulant medicine.
Severe anemia.
Adrenal failure.
Long-term systemic corticosteroids.
Ectopic pregnancy.
Mass in the tubes or ovaries.
Inherited porphyria.
Allergy to mifepristone, misoprostol or other prostaglandin medicine.
Severe diarrhea.
Future Fertility
According to studies of the Food and Drug Administration (FDA) and
the National Abortion Federation, there are no known long-term risks
associated with using mifepristone and misoprostol. Therefore, women
may pursue another pregnancy whenever they feel the time is right
after having a Medical Abortion.
MANUAL VACUUM ASPIRATION (MVA)
Methods of Uterine Evacuation
Surgical Methods of Evacuation

The primary surgical methods of uterine evacuation following incomplete
abortion in the first trimester are dilation and curettage (D and C) and
vacuum aspiration (VA).
The decision on which method should be used to empty the uterus
should be based on:
The duration of gestation

Availability of equipment and supplies
Training and skill level of staff and facility.
D and C also called sharp curettage uses mental surgical instruments
to empty the uterus. The use of D and C may entail operating theater
facilities and staff trained in surgical techniques and general anesthesia.
VA uses a vacuum of at least 55 mm Hg with a cannula made of
flexible plastic, rigid plastic or metal to evacuate the uterus. This technique
has low complication rates and involves very little trauma. It can often
be performed in a clinic or outpatient setting that requires fewer
resources and fewer staff.
Currently VA is preferred to D and C because of the lower complication
rates and the reduced need for transporting the woman to a high level
facility with an operating theater.
Types of Vacuum Aspiration

Two types of vacuum aspiration (VA) are available:
1. Electric vacuum aspiration uses an electric pump and rigid cannula
for uterine evacuation in the first trimester.
2. Manual vacuum aspiration (MVA) uses a hand held vacuum syringe
and flexible plastic cannula. Foot-operated pumps also available in
some areas. MVA was developed in the early 1970s in the US. MVA
is a safe, effective and low cost method of uterine evacuation. MVA
is a very similar to the better known technique of menstrual
regulation (MR).
Mechanism of MVA
The MVA cannula is inserted through the cervix and attached to a syringe
that contains a vacuum. A valve or two valves are compressed which
creates this vacuum. When the valve is released, the contents of the
uterus are emptied by suction into the syringe. The syringe aspirates
(provides suction), while the cannula reaches into the uterus.
Key Aspects of MVA Mechanism

It does not require electricity
It is portable
The syringe has two functions: source of vacuum and a container
The syringe (double and single valve) holds 60 cc of aspirated fluid
and tissue.
The Government of India has approved the use of MVA for termination
of pregnancy up to eight weeks of gestation. The MTP Act special provision
for this and Ministry of Health and Family Welfare (MOHFW) has issued
guidelines for use of MVA.
Uses of MVA Equipment

The single and double valve syringes may be used for performing
abortion or for treatment of incomplete abortion up to 8 weeks from the
last menstrual period (LMP) (confirmed by bimanual examination), and
the double valve syringes may be used for MVA for abortion or treatment
of incomplete abortion up to 12 weeks LMP.
The single valve syringes are also appropriate for use in obtaining an
endometrial biopsy. MVA can be used in outpatients setting, thus
increasing womens access to care.
Advantages of MVA
Incidence of hemorrhage, pelvic infection, cervical injury and uterine
perforation are lower than with D and C.
Because no general anesthesia is used, the recovery time is quicker.
Less cervical dilation is necessary.
Heavy sedation is required.
Costs for procedure, time of staff and resources are lower.
CALCULATION OF THE EFFECTIVE COUPLE
PROTECTION RATE (ECPR)
Suppose a village is having a population of 2000, with 320 eligible couples.
Sixty of the eligible couples were using condoms, ten were using oral
contraceptives, ten got IUCD inserted, four have got vasectomy and
sixteen tubectomy. Calculate the effective couple protection rate of this
village?
Effective Protection
Effective protection of contraceptive accepted:
Sterilization (Vasectomy/Tubectomy): 100%
Oral contraceptive: 100%
IUCD: 95%
Conventional contraceptives: 50%
Based on these rates the effective protection is calculated:
20 100
Sterilization = = 20
100
10 100
Oral contraceptive = = 10
100
10 95
IUCD = = 9.5
100
60 50
Conventional contraceptives = = 30
100
20 10 9.5 30
ECPR = 100 = 21.7%
320
Pearl Index
Pearl index give rise to the failure rate of the contraceptives. It is
calculated by the formula:
No. of accidental pregnancies
= 1200
No. of women observed months of use
Important Facts about Contraceptives (Tables 7.5 and 7.6)
Table 7.5: Important fact about contraceptives
Intrauterine contraceptive devices (IUCD)

Removal rate at the end of one year due to 15.16%
complication and side effects
Expulsion rate 5.15%
Perforation rate 1-3 per 1000 insertion
Ectopic pregnancy 1-30 pregnancies
Copper T 200 effective for 3 years
Copper T 380 effective for 6-8 years
NOVAT 5 years
Vasectomy reversibility
After anastomoses 60-70%
Tubectomy reversibility by tuboplasty
For laparoscopic sterilization 70%
Table 7.6: Choice of contraceptives

Subject Contraceptive
Newly married Pill
Postabortal Pill
Postpartum nonlactating Pill
Women below 35 years of age Minipill or injectable steroid
Above 35 years of age Pill
Women who smoke and above IUCD
35 years of age
Diabetic mothers/overt diabetic IUCD
Pulmonary tuberculosis on Barrier methods (condom)
chemotherapy
Heart disease (incomplete family) IUCD
Heart disease decompensated with Barrier methods (condom)
complete family Permanent sterilization of husband
BIBLIOGRAPHY
1. Clive Wood. Contraception Explained, Geneva, WHO, 1975.
2. Dalsimer I, et al. Barrier Methods, Population Report Series H:I, 1973.
3. Medical methods for first trimester abortion Cochrane review on methods
available for first trimester abortions.
4. Medical methods for termination of pregnancy report of a WHO scientific
group technical report series, No. 871.
5. National Population Policy Action Plan 2002-2003, Department of Family
Welfare, Ministry of Health and Family Welfare, Government of India.
6. Parks Textbook of Community Medicine, 16th edn.
7. Sherris JD. Barrier Methods, Population Report Series H:6, 1982.
8. WHO. The Work of WHO 1976-77, Biennial Report, 1978.
Immunization 155
Chapter
8 Immunization
CHAPTER OUTLINE
NATIONAL IMMUNIZATION SCHEDULE
NATIONAL IMMUNIZATION SCHEDULE

The age at which the vaccines are best given and the number of doses of
each vaccine is called the immunization schedule. The immunization
schedule is framed keeping in view the epidemiological pattern of the
diseases, the types of vaccines available and the administrative and
economic feasibility of providing the services. In our country we give:
Two doses of TT to pregnant women
Three doses each of DPT and OPV and one dose each of BCG and
measles vaccines to infants
School children are given DT and TT vaccines.
Immunization of Pregnant Woman

The pregnant woman develops adequate antibody titers to protect herself
and her child after birth from tetanus (NNT) only two to three weeks
after the second dose. It is recommended that the first dose be given on
first contact during pregnancy. The second dose should be given ensuring
at least one months interval after the first completing the schedule as
early as possible.
Reactions after Vaccination

Reactions after vaccination are in general mild and of a short duration.
These may be:
Mild fever
Local pain, swelling at the site of injection
Mild rash one week after measles vaccination
A lump or papule appears in the third or fourth week after BCG
vaccination.
It is generally not painful but is tender to touch. The papule increases
in size to 6 to 10 mm in diameter by the sixth week. The nodule softens
with the formation of pus. No treatment is necessary. At the end of 10
to 12 weeks only a small scar is visible .
In rare cases convulsions or collapse after DPT vaccination have been
observed. In such cases further doses of DPT should be stopped. Instead,
one dose of DT may be given (second dose). If two doses of DPT have
already been administered, further doses are not required.
Complications
Abscess formation is usually due to the use of unsterilized or inadequately
sterilized syringes and needles.
The injections are painful if blunt needles are used.
Determine Needs and Requirement

Estimation of Eligibles
Your aim is to provide universal immunization coverage in your area. In
order to do this you must have an estimate of the total annual number
of pregnant women and infants. The numbers can be calculated by using
the formula given below:
Population Birth rate = No. of pregnant women
Population BR (1-IMR) = No infants at one year of age.
For example,
If the population served by a health center is 50,000, the birth rate-
30/1000.
And IMR 100/1000 live births, the expected number of pregnant
woman and infants will be:
50,000 0.03 = 1500
50,000 0.03 (1-0.01) = 1350
The estimates of the pregnant women and infants should be worked
out at each level locally and compare with the list maintained by the
health worker to ensure completeness of registration.
The health workers should have a list of the pregnant women and
infants in the areas covered by them. The list should be kept up to date.
The information can easily be obtained during, their visits to the villages
and also through the village level workers such as dais,VHGs, anganwadi
workers (AWWs) and others. The name of the child should be registered
soon after birth, the vaccinations being given when the child reaches the
right age.
At any given time, 100 percent of the total estimated annual number
of infants and 60 percent of the pregnant women should be registered.
If the numbers do not fall within 10 percent of your estimates, it is your
responsibility to get the lists updated immediately. You may already
have the required information in the Eligible Couples and Child Register
(ECCR).
Estimation of Number of Contacts

The number of vaccination sessions to be scheduled depends upon the
number of children to be vaccinated in the area served by the health
center or vaccination site. If there are ten or more children to be vaccinated
Immunization 157
each day, schedule daily sessions. This will ensure that all children can
be vaccinated at the earliest acceptable age and will therefore, give them
the best protection against disease. If there are fewer than ten children
to be vaccinated each day,the vaccines and the time of the health staff
may be wasted by holding daily sessions, so it is better to plan fewer
vaccination sessions.
To determine the number of children to receive vaccinations per month
(monthly target population), divide the number of children to receive
vaccinations for the year by 12 and multiply by the number of doses of
the vaccine which need to be given.
Contaminated vaccines can lead to severe reactions including death.
Use only sterile syringes and needles to mix vaccines and to draw them
from the vials or ampoules (Measles and BCG vaccines). Use a single sterile
syringe and needle for each injection. Do not use opened vials in subse-
quent sessions. Display these instructions at all sites where immunization
sessions are conducted.
The parents should be informed of the expected side effects so that
they do not worry. If there is any anxiety they should be encouraged to
return to the health center for consultation.
Difference between EPI and UIP

Expanded Program of Immunization (EPI)
Started in 1978
High coverage of children under two years and pregnant women
DPT, BCG and TT vaccines
DT and TT vaccines for school children
Oral polio vaccine added in 1979.
Universal Immunization Program (UIP)

Started in 1985
Universal coverage of infants and pregnant women
Measles vaccine added to the program
Strengthen cold chain
Take up districts in phases.
National Immunization Schedule (Tables 8.1 and 8.2)

Table 8.1: Schedule of National Immunization
a. For Infants
At birth (for institutional deliveries)$ BCG and OPV-O dose Hepatitis B*
At 6 weeks BCG (if not given at birth) Hepatitis B
DPT-1 and OPV-1 Hepatitis B
At 10 weeks DPT-2 and OPV-2 Hepatitis B
At 14 weeks DPT-3 and OPV-3 Hepatitis B
At 9 months Measles
Contd...
Contd...
b. At 16-24 months DPT and OPV (Booster 1)
c. At 5-6 years DPT (Booster 2) OPV #
d. At 10 and at 16 years Tetanus toxoidThe second dose of TT
vaccine should be given at an interval of
one month if there is no clear history or
documented evidence of previous
immunization with DPT, DT or TT vaccines
e. For pregnant women TT1 TT2
Early in pregnancy
One month after
Note: i. Interval between two doses should not be less than one month.
ii. Minor cough, colds and mild fever are not a contraindication to vaccination
iii. In some states Hepatitis B vaccine is given as routine immunization.
$ For institutional delivery OPV and Hepatitis B is considered as zero dose.
# Initially DT used to be given recently DPT is advocated
Table 8.2: Some more vaccines in the immunizations schedule

Vaccine Dose Age Cost per dose
1. Hepatitis A 1st Dose Before 1st year of birth
2nd dose After 1 year of birth Rs 900
2. Chickenpox One dose After 1st year within 2 years Rs 1,300-1,500
3. Typhoid After 3 years, repeated Rs 150
every 3 years
4. Meningitis 1st dose 1 months Rs 450
2nd dose 2 months
3rd dose 3 months
Note: i. Interval between doses should not be less than one month
ii. The dose of all vaccines is 0.5 ml except BCG which is 0.1 ml polio vaccine is given
by mouth in 2 drops.
iii. Check the label of the vial before use.
The Indian Association of Pediatrics recommends four more vaccines

in the immunization schedule which is not recognized by the WHO.
Although these are optional, it is safe to get them done.
A PHC would roughly be required to keep 400 to 500 vials a month.
Such quantities can be easily stored in an ordinary refrigerator.
Cold boxes, vaccine carriers and day carriers would be needed to
carry vaccines to the lower formations and to the field. The total numbers
will depend on the number of the centers, the staff in position and the
strategies adopted for coverage.
Estimation of Requirements of Syringes and Needles

The total number of syringes and needles that you would require will
depend on the number of pregnant women and infants you plan to
immunize. It is expected that an ordinary glass syringe would be used
at least 50 times and a needle 10 times before replacements are made.
Reusable plastic syringes are also being supplied to the UIP districts.
Such syringes can be steam sterilized up to 200 times.
Immunization 159
The calculations of syringes and needles is quite simple:

Total number of pregnant women and infants to be covered
number of doses of each vaccine (total number of injections)
50 (glass syringes)
200 (plastic syringes)
10 (number of needles)
This calculation gives annual requirement of syringes and needles.
However, for any session syringes to be carried will depend on the expected
number of injections to be given. At this rate about 500 syringes and
needles are required for each PHC.
A sterile syringe and needle should be used for each injection. The
total number of syringes and needles at each PHC session should not be
less than the expected number of children and pregnant women during
the session. The syringes and needles should be sterilized before the
session.
You must ensure that adequate quantities of the syringes and needles
have been distributed to the field workers and replacements are made
to them periodically or autoclaved syringes and needles should be
provided on the day of session.
Estimation of Requirements of Sterilization Equipment

Arrangements must be made for the sterilization of syringes and needles
for the immunization sessions.
Each visit to the health center or vaccination site for vaccination is
called as contact. Minimum four contacts are required for one child to
receive the complete series of vaccinations, so the total number of
contacts will be four times greater than the number of children in the
target population. Two contacts with each pregnant woman are expected.
Estimation of Vaccine Needs

Estimation of vaccine requirements and ordering for the right quantities
of vaccine is critical for the success of your program. The requirements
depend on the population to be covered and the number of sessions to
be held (periodicity of supply).
The vaccine requirements will depend on the number of pregnant
woman and children and on the number of sessions held.
The calculations for vaccine requirements are simple:
Total number of infants/pregnant women to be covered
No. of doses of the vaccine
WMF (Wastage Multiplication Factor)*
No. of sessions proposed to be held.
* WMF: 1.33 for DPT, DT, TT and OPV, 2 for BCG and Measles.
The vaccines are supplied in 10 or 20 doses vials or ampoules. The

required number of doses are divided by 10 or 20 and rounded off to
the next nearest number of vials or ampoules.
You must always check your previous balance stocks before placing
order for fresh.
You must monitor the performance reports from the centers to which
you supply vaccines to ensure that the expected number of pregnant
women and infants are being immunized and the vaccines are not
wasted. If the attendance is low, vaccine supplies must be suitably
reduced till you can find out the reasons and take corrective measures
to step up coverage.
Health centers should not keep more than one months requirements
and no vaccine should be stored at a subcenter.
Estimation of Cold Chain Requirements

All vaccines must be kept at +2C to + 8C otherwise they lose their
effectiveness to protect against diseases. The cold chain requirements will
depend on the quantities of vaccines to be stored and the period for which
they will be stored.
It is estimated that cold storage facilities for roughly 30,000 to 40,000
vials of all vaccines will be necessary at the district level (>3 months
requirements of an average district of 2.5 million population).
Storage capacity of around 900 to 1200 liters is required to store the
above quantities of vaccines.
Each task described in the task description must be included somewhere
in a job description of an individual staff member. Otherwise it will not be
clear who is to perform which tasks and some steps may not always be
performed or may not even be performed at all.
Make a list of the activities and allocate job responsibilities to the staff.
Ensure that the following tasks are covered:
a. Vaccination coverage of pregnant women and infants.
b. Stores including vaccines. The person concerned should indent the
required quantities of vaccines and other supplies in time. He should
be responsible for the distribution of the required quantities to the lower
formations and also for monitoring that the supplies are used properly.
c. Monitoring and supervision of services.
d. Preparation and display of health education material, advance plan
for health talks in the community prior to outreach operation and
compaigns.
e. Recording and keeping reports in order, compilation and analysis of
the reports. Forwarding the reports to the higher formations and
providing feedback.
f. Surveillance of diseases.
Immunization 161
Although, you may delegate some of the duties to others, the final
responsibility for ensuring that the immunization sessions are organized
efficiently and effectively is yours.
Determine Training Needs

You are expected to immunize all pregnant women and infants in your
area. This means that you must contact all the eligibles. Since some of the
vaccines require repeated dose, each child must be contacted at least
five times.
It is clear that unless the quality of the services is high it will not be
possible to achieve universal immunization coverage. The planning and
implementation of the program must be meticulous. There is no scope
for any default in the services. Even temporary dislocation can prove
disastrous. Critical to the success of the program will be the high quality
and easy accessibility of the services.
It is expected that the Medical Officers at the PHC level responsible for
the immunization program will attend four day course at the district
level. The course will cover the modules on surveillance, cold chain and
organization of immunization sessions. In addition, the manual for the
health workers should also be covered.
All the MPWs and their supervisors are expected to undergo a two
day task oriented course and cover the manual for the health workers.
The course should include practical demonstration of all the items
covered in the manual. The manuals are available in the regional
languages.
Each PHC has been provided with an autoclave. The syringes and
needles required for the sessions held at the PHC can be autoclaved the
previous evening.
Three or four subcenters may organize vaccination sessions on the
same day. These subcenters must be supplied vaccines from the PHC on
the day of the sessions. The feasibility of autoclaving the required number
of syringes and needles at the PHC and supplying them to the subcenters
along with the vaccines must be seriously considered. This will ensure
proper sterilization of the syringes and needles, save the time of the
ANMs at the subcenters and also avoid the logistics of supplying
kerosene and sterilization equipment to the subcenters.
Where the above arrangements are not operationally feasible stoves
and pressure sterilizers must be provided to the subcenters. It will also
be your responsibility to ensure that adequate stocks of kerosene are
available. This should be replenished regularly.
Boiling of syringes and needles at outreach sites should be done only
as an emergency and not on a routine basis. Sufficient number of sterilised
syringes and needles should be taken by the health staff to the outreach
sessions. The numbers taken should be at least 10 percent more than the
expected number of children and pregnant women to be vaccinated on

that day.
Estimation of Requirements of Immunization Cards
Vaccination cards must be given to all the pregnant women and infants.
The card used for the pregnant women can be later used for the infant
after the birth of the child. The cards should be in the regional language.
During the first year of the program you will, however, need more
cards for the infants.
The number of cards you would need is as follows:
First yeartotal number of pregnant women and infants +10 percent
Latertotal number of pregnant women + 10 percent.
Manpower Needs
You must clearly define:
Task description of all the steps to be performed in order to carry out
each major step. Task descriptions describe what must be done.
Job responsibilities describe the tasks to be performed by the staff member.
Job responsibilities describe who will do the work.
Enumerate Eligibles
The vaccine requirements depend on the eligibles and the number of
sessions to be held. The simplest and best way to know the eligible is
house to house enumeration of pregnant women and infants. The village
wise enumeration at a particular period should get the information of
infants according to month of birth. Though enumeration can be done
at any time in the year, it is ideal to do in the first week of April every
year. Thereafter, regular updating of the eligibles must be done during
the routine visits. However, the number of eligibles in the future months
can be assumed to be same as the corresponding period of the previous
year. Pregnant women should be registered at the earliest period of
pregnancy and expected date of delivery (EDD) should be worked out.
Obtain Vaccines
Estimation of the vaccine requirements and ordering for the right
quantities of vaccines is critical for maintaining the cold chain. The
requirements depend on the population to be covered and the number
of sessions to be held (periodicity of supply). Estimation based on the
following formula will enable the supervisors to assess the vaccine
requirements and to verify the correctness of enumeration.
Estimation of Vaccine Requirements

Total number of pregnant women/infants in the area.
Proposed coverage
Number of doses of the vaccine to be given (including booster dose)
Immunization 163
Vaccine administration rate *(VAR).

Periodicity of supply (depending on the number of sessions held per
month).
For example, in an area with a population of 5,000 birth rate of 30/
1000 and IMR of 100/1000 live births, the estimated number of pregnant
women and infants is calculated as follows:
Eligibles:
Pregnant women = Population BR
Infants = Population BR (1 IMR)
Pregnant women = 5,000 0.03 = 150
Infants = 5,000 0.03 (1 0.0) = 150 9 = 135
Vaccine requirements are calculated based on the following formula:
Number of vials required = Number of eligibles expected coverage
Number of doses VAR Number of
doses per vial.
Instead of dividing by VAR you can multiply by wastage multiplication
factor (WMF) as indicated by equivalents below:
VAR WMF
50% 2
75% 1.33
90% 1.11
Thus, the formula using WMF will be:
No. of eligibles expected coverage No. of doses WMF No. of
doses per vial continuing with the example on previous page.
Requirement of TT = 150 100/100 2 1.33 = 400 doses.
This is annual requirement of TT for pregnant women.
Monthly requirement = 400 12 = 34 doses 10 = 4 vials.
If sessions are held fortnightly, divide by 24 and if weekly, divide by 52.
Although minimum coverage required for DPT, OPV, BCG and measles
is 85 percent, it is better to calculate vaccine requirements for 100 percent.
Accordingly in the example cited, requirement of DPT/OPV will be:
135 100/100 4 1.33 = 720 doses (4 doses include 3 primary and
one booster)
Accordingly, monthly and fortnightly requirements will be 60 and
30 doses.
BCG/Measles = 135 100 100 1 2 = 270 doses.
Accordingly, monthly and fortnightly requirements will be 25 and
13 doses.
The vaccines are supplied in 10 or 20 dose vials or ampoules. The
required number of doses are divided by 10 or 20 and rounded off to
the next higher number of vials or ampoules.
Since, the subcenters are not supposed to keep vaccines there will be
no balance stocks from previous supplies.
(Note:*Vaccine administration rate: It is the number of doses actually administered
to beneficiaries out of one hundred doses of the vaccine).
You must monitor the performance reports from the subcenters to

ensure that the expected number of pregnant women and infants are
being immunized and the vaccines are not wasted. If the attendance is
low, vaccine supplies must be suitably reduced till you can find out the
reasons and take corrective measure to step up coverage.
Maintain Vaccines
When administrating vaccine to expectant mothers and infants at the
vaccination site, you must take great care not to expose the vaccine to
heat and sunlight. To do this:
Select a vaccination site that is as cool as possible, preferably inside a
room. If a room is not available, vaccinate in the shade. Do not vaccinate
in the sunlight.
Open the carrier only when necessary
Remove vaccine and diluent from the vaccine container, only when
you need it.
Take only vial of one type of vaccine from the container at a time. Do
not take the second vial from the carrier until it is needed.
Secure the lid tightly after opening as soon as possible
Wrap the BCG ampoules in a dark paper to protect them from heat
and light.
When you take vaccine out of the container, place vials inside a cup
containing ice. If the ice melts and no mothers and children are waiting,
put the vials back into the cold chain container until a mother arrives.
Then place the vials inside the cup with ice.
When the vaccination session is completed, return all vials to the health
center store, if ice packs in the carrier still contain ice, mark unopened
vials by putting rubber band, and return them to the refrigerator. Be
sure to use these marked vials during the next vaccination session.
Do not take the same vial of the vaccine out to the field more than
three times. If a vial of vaccine has been taken to the field third time,
return it to the PHC after marking Discard. You must, however, be
careful that vaccines are not wasted in this way too often.
Keep opened vials in plastic bag and return these to PHC at the
end of the session for discarding by an identified person.
If the ice in the cold chain container is completely melted for less
than one day:
i. Discard polio vaccine, so that no one else can use.
ii. Mark the remaining DPT, tetanus toxoid, measles and BCG
vaccine, return it to the refrigerator, and use it during the next
vaccination session.
If the ice in the cold chain container is completely melted for more
than one day throw away all vaccines.
Keep a record of the vaccine you administer.
Immunization 165
Keep record of the batch numbers and the expiry dates of the vaccines
used.
Keep a record of vaccines returned to PHC.
The administration rate of the vaccines will depend on the number of
sessions held and the attendance at the sessions. The fewer the number
of pregnant women and infants per session the lower will be the
administration rate. This is because opened vials must be discarded at
the end of the session. On an average, the administrative rates of all
vaccines is estimated to be 75 percent except BCG and measle-vaccines
for which the administration rate is around 50 percent.
Sometimes the services may have to be intensified to cover up the
back logs. On the other hand, due to various reasons, such as heavy
rains, priorities of other programs, vacant posts, etc. services may be
considerably reduced during some months of the year. Thus, the
monthly requirements will be more in some months and less in others.
The supplies to the subcenters must be adjusted accordingly with less
vaccines being supplied over some months and more during the others.
This must be part of your planned activities.
Before the vaccines are despatched, make sure to check the ice packs
of the vaccine carriers. These should be frozen solid. If using thermocol
carrier, these should be packed at least 1/3rd with ice.
Check that the types and amounts of vaccine and diluent are the same
as you estimated.
Check that the expiry date on each vial of vaccine has not passed.
Check that DPT, DT, TT vaccines have not been frozen. The solution
of such vaccines, on shaking is not uniform. Small granules or floccules
will be seen. Such vaccine also forms sediment faster than the normal
vaccine (shake test).
If you are sending vaccines to more than one subcenter see that the
subcenters fall on the same route and if one person can deliver the
vaccines taking the shortest route. The vaccines should reach the
subcenters in time for the vaccination sessions.
Any unused vaccine left at the end of the day should be returned to
the PHC on the same day. No vaccine should be stored at the subcenter.
These vials should be kept in a separate box in the refrigerator marked
returned. Put a rubber band around the vial to indicate that it was
taken out once, two rubber bands if taken out twice. Any vial which has
been taken out three times and not used, must be discarded. You must,
however, be careful that this does not happen too often.
Maintain Equipment
Vaccine and diluent taken from cold storage can be kept for several
hours if packed properly in well insulated cold chain containers. To do
this, three types of cold chain containers are available for your use:
A cold box
Vaccine carrier
A day carrier.
Vaccine
BCG
History: Developed in the year 1927 by Calmette and Gurin from bovine
bacilli after 230 subcultures (Table 8.3).
Table 8.3: Milestones in vaccination

1796 - First vaccination. Jenner tests for smallpox resistance
1883 - Vaccination for children against rabies
1892 - Cholera vaccine
1913 - Toxoid, antitoxin immunization against diphtheria
1921 - BCG vaccine
1923 - Diphtheria toxoid
1923 - Pertussis vaccine
1927 - Tetanus toxoid
1937 - Influenza vaccine
1937 - Yellow fever vaccine
1949 - Mumps vaccine
1954 - Salks polio vaccine
1957 - Sabins oral polio vaccine
1960 - Measles vaccine
1962 - Rubella vaccine
1968 - Type C meningococcus vaccine
1970 - Researchers in Israel proved that injection of a peptide from a virus or
disease can induce the production of antibodies that recognize the entire
virus or disease
1971 - Type A meningococcus vaccine
1980 - First commercial vaccine for Hepatitis B
1982 - First vaccine produced through genetic engineering (vaccines for diarrhea
in pigs)
1982 - First synthetic vaccine created at Institute Pasteur and at Weizmann
Institute from diphtheria toxin.
Aim: To induce benign artificial primary infection which will stimulate

an acquired resistance to possible subsequent infection with virulent TB
bacilli and thus reduce mortality and morbidity from pulmonary TB
among those most at risk.
Vaccine
It is a live bacterial vaccine. It consists of living bacteria derived from
an attenuated bovine strain of TB bacilli
Vaccine is prepared from Danish 1331 strain since Jan 1967 at BCG
laboratory Guindy, Chennai.
Immunization 167
Potency
Vaccine is stable for up to one year if stored below 10C
At room tempone month
During summerone weeks
After reconstitution with normal salinethree hours.
Protection
Protect it from sunlight.
Types of vaccine: Liquid vaccine (fresh) and freeze dried vaccine
Storage: Wrapped in a double layer of red or black cloth.
Dosage:
0.1 ml for infant
0.05 ml for neonate (< 4 weeks)
0.1 ml in neonate penetrats into deeper tissue and gives rise to local
abscess formation and lymphadenopathies (axillary).
Route of Administration
Intradermal using a tuberculin syringeomega microstate syringe fitted
with 1 cm steel 26 gauge intradermal needle.
Site: Just above the insertion of the deltoid muscle. A satisfactory injection
should produce a wheal of 5 mm in diameter. The vaccine must not be
contaminated with an antiseptic or detergent.
Age: Immediately after birth for institutional delivery or at six week of
age simultaneously with DPT and polio, it should always be completed
by one year. It can be given up to 20 years irrespective of tuberculine
status.
Complication
Ulceration at site and suppurative lymphadinitis occur in1 to 10 percent
of vaccination.
Osteomyelites, disseminated infection occur in<1 percent/million
vaccination.
Abscess formationRx incision and drainageRx with PAS or INH
powder.
Protective value: Range of protection 0-80 percent is from 15 to 20 years,
it gives protection against childhood TB, tubercular meningitis.
Contraindications
1. Generalized eczema
2. Infective dermatitis
3. Hypogamma globulinemia
4. History of deficient immunity.
Oral Polio
Oral polio vaccine was described by Sabin in 1957.
It contains live attenuated vaccine (Type 1, 2 and 3)
Grown in monkey kidney HDCC (Human Deploid Cell Cultures).
The vaccines contain:
i. 300000 TCID 50 g type 1 polio virus
ii. 100000 TCID 50 g type 2 polio virus
iii. Over 30000 TCID 50 g type 3 polio virus per dose.
National Immunization Schedule

BCG may be given at the same time as the oral polio vaccine. DPT vaccine
may also be given at the same time as BCG but in different areas:
Three doses of OPV at one month interval commencing first dose
when the child is 6 weeks old.
It is very important to complete vaccination for all infants before six
months of age.
Because most of the polio cases occur at the ages of six months and
three years one booster dose OPV is recommended 12 to 18 months
later.
If vaccine is spoon fed spoon should be boiled in water and cooled in
ice water before administering vaccine. Dont use disinfectant for
sterilization of spoon.
Development of Immunity
Live vaccine strains infect intestinal epithelial cells after replication, the
virus is transported to the payers patches where secondary multiplication
with subsequent viraemia occurs. The virus spreads to other areas of
body, resulting in production of circulating antibodies and prevent
paralytic polio.
Intestinal infection stimulates the production of IgA secretory
antibodies which prevent subsequent infection of the alimentary tract
with wild strains of polio virus and is effective in limiting virus
transmission in the community.
Oral Polio Vaccine (OPV)
It includes both local immunity and systemic immunity. Virus is excreated
in feces and secondary spread occurs to house hold contacts and
susceptible contacts in the community. Nonimmunized persons may
therefore be immunized. Thus, widespread herd immunity results,
even if only 66 percent approximately of community is immunized.
Immunization 169
Therefore, this property of OPV has been exploited in controlling

epidemics of polio by administration of vaccine simultaneously in a short
period to all susceptibles in a community. This procedure, virtually
eliminates wild polio strains in the community. Wild polio is replaced
by attenuated strains.
Failure of Three Dose Regimen
The proportion of children developing antibody after three doses of
trivalent vaccine can be as low as 30 percent in tropical countries as
against the more usual 90 percent in temperate climate countries.
Failure of OPV
Increased gradually from 5 percent in 1960 to 30 percent currently.
To overcome this failure Indian academy of pediatric has recommended
five dose of OPV in clinic based programs. Some have recommended
yearly dose up to eight years.
At the vaccination clinic, the bottle containing the OPV should not be
frozen and thawed repeatedly. It would be preferable to keep the vials
of the vaccine in ice during its administration to children.
Breastfeeding does not impede the effectiveness of OPV. However,
hot water, hot milk or hot fluids should be with held for about half an
hour after the administration of the vaccine. The vaccine should be
administered preferably in a cool room, rather than in a hot, humid and
crowded room.
Complications
Risk of vaccine associated paralysis is 1 case/1 million vaccination. Risk
of close contact of vaccine developing paralytic polio is about 1 case/5
million dose of vaccination.
Contraindications
For administration of OPV are fever, diarrhea, dysentery, leukemias,
malignancy, those receiving corticosteroids. These are only relative
contraindications.
Storage
OPV(Heat stabilized) can be stored without losing potency for a year at
4C and for a month at room temperature. Nonheat stabilized vaccine
should be stored at 20C in a deep freeze. If deep freeze is not available
it might be stored temporarily in freezing chamber of refrigerator.
Salk Polio Vaccine
Inactivated by formaline. It contains 20, 2, and 4 D antigens unittype
1, 2 and 3 respectively.
third doseat an interval of one to two months

fourth dose6-12 months after 3rd dose
Additional dosesrecommended prior to school entry and then every
five years until the age of 18 years. One or two dose of OPV are given
safely as booster after an initial course of immunization.
Inducehumeral antibodies (IgM and G, A) serum antibodies.
Advantages
Safe to administer in:
1. Person with immune deficiency disease.
2. To person undergoing corticosteroid and radiation therapy.
3. For those over 50 years who received vaccine for 1st time.
4. During pregnancy.
Strategies for Polio Eradication

1. Conduct Pulse Polio Immunization (PPI) days every year for three to
four years or until polio myelitis is eradicated.
2. Sustain high level of immunization coverage.
3. Monitoring OPV coverage at district level and below.
4. Improve surveillance capable of detecting all cases of Acute Flaccid
Paralysis (AFP) due to polio and non-polio etiology.
5. Ensure rapid case investigation, including the collection of stool
samples for virus isolation.
6. Arrange follow-up of all cases of AFP at 60 days to check for residual
paralysis.
7. Conduct outbreak control for cases confirmed or suspected to be polio
myelitis to stop transmission.
Even a single case is treated as an out break and preventive measures
are initiated, usually within 48 hours of notification of case. Reporting
of all cases of acute flaccid paralysis in children under 15 years of age is
mandatory and line lists of all reported cases of polio are maintained.
Current Four Basic Strategies to Eradicate Polio

Routine Immunization
Immunize every child aged < 1 year with at least four doses of oral polio
vaccine.
National Immunization Days (NIDs)/Pulse Polio
Immunization (PPI) Program
Conduct by giving additional doses of OPV, four to six weeks apart to
every child aged < 5 years. Intensification of the Pulse Polio Immunization
Immunization 171
Program can be done by adding additional rounds, house-to-house

search and vaccinate component to the fixed post approach. Intensifica-
tion of PPI needs a meticulous planning of the program along with
intensive supervision and monitoring besides social mobilization effort.
National Immunization Days

In India, transmission of polio has dramatically reduced from 1934
laboratory confirmed cases in 1998 to 1126 in 1999 and just 263 in 2000. It
is decided that there is a need to make extra-efforts to reach the
unreached during Pulse Polio Immunization Days. For that reason
Intensified Pulse Polio Immunization was proposed and just after the
National Immunization Day a immunisation team would go to house to
check whether the child has received pulse polio vaccine and if not given
then child must be given a dose. An elaborative work plan has been
proposed for each supervisor to ensure that no child is left without
polio vaccine.
Surveillance of Acute Flaccid Paralysis (AFP)

To identify all reservoirs of wild poliovirus transmission.
Objective
To find places with circulation of wild poliovirus.
Components
Establishment and maintenance of reporting units (RUs): Reporting units form

the backbone of surveillance network. These are hospitals, pediatricians,
doctors, and medical/health establishments in government or private
sectors who are likely to see a case of Acute Flaccid Paralysis (AFP). The
reporting units are well distributed to cover all areas in the country.
Apart from reporting AFP cases immediately, the RUs send a weekly
AFP surveillance report to the District Immunization Officer (DIO)
irrespective of whether or not they see a case of AFP during the work.
Each RU has a nodal officer responsible for reporting and upkeep of
records. At present, 8,453 RUs are participating in AFP surveillance
throughout India. Apart from these, numerous small clinics, private
practitioners, doctors of Indian systems of medicine, quacks (all together
termed as informers) report AFP cases whenever they see them. Both
the Surveillance Medical Officer (SMO) and DIO are involved in the
creating of a sound reporting network and visiting regularly to the
reporting units in their area and conducting active case searches in the
RUs at regular intervals to look for any cases that might not have been
reported.
AFP case notification: The RUs and informers notify AFP cases immediately
to the DIO. Since very important activities like stool specimen collection,
outbreak response immunization, active case search in the community,
etc. should occur early, rapid notification is very essential.
AFP case investigation: An AFP case is immediately investigated, usually
within 48 hours of notification, by DIO or SMO. After confirming the
case as AFP, the DIO clinically examines the child, takes history and fills
a standard Case Investigation Form (CIF).
Stool specimen collection and transportation: From every case of AFP,
2-stool specimens are collected. The aim is to get these specimens at the
earliest, within 14 days of onset of paralysis (or maximum of eight weeks)
and at least 24 hours apart. Each specimen is 8 grams or about adult
thumb size collected in a clean, dry screw capped container. The container
need not be sterile and no preservative/transport media is used. The
specimens are collected, labeled and transported in cold chain to the
designated national lab. A standard Lab Request Form (LRF) is filled
that accompanies the stool specimen. Special stool specimen carriers have
been provided to districts for this purpose. Stool specimens are collected
from all AFP cases detected within eight weeks from the onset of
paralysis.
Virological Classification Scheme (Flow chart 8.1)
Flow chart 8.1: Virological classification scheme
** 2 Specimen at least 24 hours apart and within 14 days of onset paralysis: each specimen
must be of adequate volume (8-10 grams) and arrive at a WHO accredited laboratory in good
condition (i.e. no desiccation, no leakage; adequate documentation and evidence that the cold
chain was maintained)
Immunization 173
Process of AFP Surveillance (Flow chart 8.2)
Outbreak response immunization (ORI): Following stool specimen

collection, outbreak response immunization is organized in the community.
All 0 to 59 months old children are given one dose of oral polio vaccine
irrespective of their previous immunization status while going house to
house. The recipients include all target children in the village/locality.
At least 500 children are vaccinated. The ORI is performed as soon as
possible. The travel history of the child may suggest additional places
of stay where ORI should also be conducted. While conducting the
house-to-house immunization during ORI active case search is conducted
in the community.
Active case search in the community: In the community where an AFP case
lives, a house-to-house active case search is organized to find more AFP
cases if they have occurred. This activity is carried out immediately
along with Outbreak Response Immunization (ORI). The case definition
used during searches is: Flaccid/floppy paralysis in a child between
0-15 years of age with onset within last 60 days. All the cases that are
found are investigated immediately and have two stool specimens taken
before the child is given Oral Polio Vaccine (OPV). The purpose of the
search is to fully uncover additional polio cases, if any, in the community.
Sixty days follow-up examination: The District Immunization Officer or
Surveillance Medical Officer revisits every case of AFP 60 days after the
onset of paralysis to confirm the presence or absence of residual weakness.
Child is assessed for weakness, asymmetrical skin folds, and difference
in left/right mid-arm/mid-thigh circumference. The child has residual
weakness, if any of the above is present, even if minimal. This activity is
completed before 70th day of onset of paralysis.
Cross notification and tracking of cases: The cases are investigated anywhere
in India irrespective of where the child lives. A very advanced
communication system (telephone/fax/e-mail) has been established that
sends information to DIO of the resident district of AFP case
immediately. The AFP case is constantly tracked by SMOs to complete
all the activities related with surveillance. This also leads to realistic and
complete epidemiological picture at district level.
Data management and analysis: At the end of each week, DIO reports to
the State EPI Officer the line of all new AFP cases, reported during that
week. He summarizes the activities and reports the current status of
investigation and the follow-up of AFP cases. Reporting takes place even
when no cases of AFP have been identified. The data is entered into
computers at National Polio Surveillance Unit (NPSU) and is used for
program monitoring, checking quality of data and assessing progress
towards eradication. The data is analyzed for taking appropriate action.
Flow chart 8.2: Process of AFP surveillance
Case classification: When lab results and 60 days follow-up examination

reports are available, the cases are classified at NPSU as polio or non-
polio. Until 1999, the clinical system of classification was being used.
According to this scheme, a case is classified as polio if wild poliovirus
is isolated. If two adequate stool specimens have been collected (24 hr
apart) from the case within 14 days of onset of paralysis and the stool
results are negative then the case is non-polio. If the case had inadequate
stool specimen and the AFP case had residual weakness, died or lost to
follow-up then that case is classified as polio. From January 2000, India
has shifted to the advanced virological system of classification. Cases
with inadequate stool specimen and having residual weakness, died or
lost to follow-up are subjected to special investigation and are presented
for the review by the Expert Group at national level. The Expert Group
classifies the case as compatible or discarded. This has been possible
due to the achievement of a high level of surveillance of AFP.
Feedback: In order to give feedback, the reports and maps, which are
generated by NPSU, are on the website. NPSU also sends line lists of
the cases to the states twice a month.
Conduct Extensive House-to-House

Immunization Mopping-up Campaigns
In the final stages in focal areas where wild poliovirus transmission
persists.
Immunization 175
Mopping-up: Conduct extensive house-to-house immunization mopping-

up campaigns: Experience in previous years has shown that though the
National Immunization Days (NIDs called as Pulse Polio Immunization
or PPI in India) decrease polio transmission and delay the annual peak
in high endemic states, the virus persists and bounces back in the later
half of the year. But to achieve eradication quickly, it will be critical to
target the remaining districts with extra rounds of house-to-house
immunization early in 2001 before the onset of the hot summer and the
subsequent high season of polio during the rains.
Mopping-up is not a Sub-National Immunization Day (SNID). SNIDs
are done when there is widespread and dispersed transmission in a
part of the country and is aimed at reducing the transmission to clearly
delimited, focal areas. SNIDs are not an end-game strategy and can be
repeated a few times if needed. On the other hand, mopping-up is aimed
at stopping transmission in a defined area. This cant be repeated too
many times. In mopping-up the virus from an area or population, there
are no shortcuts to reaching all children. Going house-to-house or family-
to-family are tools to achieve that elusive goal of reaching all eligible
children.
Line Listing of Cases

Started in 1989.
Aim of line listing of cases
1. To check for duplication (Same case reported more than once).
2. Year of onset of illness to screen the children with residual paralysis.
3. Identification of high-risk pockets.
4. Documentation of high-risk age groups.
Intensive Pulse Polio Immunization (IPPI)

1. It will reduce number and size of high-risk areas.
2. Increase in the involvement of health official in the planning process.
AFP surveillance information in planning of immunization activities
by helping and monitoring of the technique.
Strategies Involved to Achieve Intensification of PPI

Conduct Nation wide four Pulse Polio Immunization (PPI) rounds based
on June 1999 recommendation of Global Technical consultative group
in polio myelitis eradication.
Four roundswith four weeks apart from 1999-2000
First daybooth based 2nd and 3rd dayhouse-to-house search
Aimhundred percent immunization.
In addition2 supplementary rounds in February 27th to 29th and
March 26th to 28th in eight priority states Uttar Pradesh, Madhya Pradesh,
West Bengal, Bihar, Rajasthan, Assam, Gujarat, and Orissa.
Vaccine Vial Monitoring

During the IPPI there is a need to reach every eligible
child with potent oral polio vaccine. The Vaccine Vial
Monitor (VVM) is a simple tool, which enable the
vaccinator to know whether vaccine is potent at the
time of administration.
On the vaccine vial there is a circle mark in which a
small square is printed which is either white or lighter
than the color of circle that indicate that the vaccine is
potent and can be used. However, if the color of square
is dark or of same color as circle mark then the vaccine
should be discarded.
Measles Vaccine
Measles is best prevented by active immunization. Only
live attenuated vaccines are recommended for use.
No egg culture vaccine are produced at all today.
All are tissue culture vaccinechick embryo, HDCC (Human diploid
cell culture)
It is a freeze dried product.
Age
1. The most effective compromise is immunization as close to the age of
nine months as possible.
2. If there is measles outbreak in community, measles vaccine should be
started at sixth month.
3. For infants immunized between six and nine months of age, a second
dose should be administered as soon as possible after the child reaches
the age of nine months provided that at least four weeks have elapsed
since the last dose.
4. In countries where the incidence of measles has declined, the age of
immunization is being raised to 15 months in order to avoid the
blocking effect of persistent transplacentally acquired antibody.
Storage
Heat stable measles vaccines able to maintain their potency for more
than 2 years at 2 to 8C have been developed.
Administration
It is administered in a single subcutaneous dose of 0.5 ml.
Immunization 177
Diluting fluid for reconstituting the vaccine must be kept cold at 4 to

8C.
The reconstituted vaccine should be kept on ice and used within one
hour
Measles vaccine has recently been adapted for aerosol administration.
Reactions
When injected into the bodyattenuated virus multiplies and induces a
mild measles illness (fever and rash) 5 to 10 days after immunization
But reduced in frequency and severity. This may occur in 15 to 20
percent of vaccinees.
Fever may last forone to two days and the rash for one to three
days.
There is no spread of the virus from the vaccinees to contacts.
Immunity
Develops within 11 to 12 days after vaccination
Appears to be of long duration probably for life.
One dose of vaccine offers 95 percent protection.
Contacts
Susceptible contacts over the age of 9 to 12 months may be protected
against measles if vaccine is given within three days of exposure. This is
because incubation period of measles induced by vaccine is about seven
days compared to 10 days for the naturally acquired infection.
Contraindications
1. Pregnancy is positive contraindication
2. Acute illness
3. Defective cell mediated immunity
4. Steroids and immunosuppressive drugs.
Adverse Effects of Vaccine

Toxic shock syndrome (TSS) occurs when measles vaccine is contaminated
or same vial is used for more than one session on the same day or next day.
Vaccine should not be used after four hours of opening the vial. TSS
is totally preventable. TSS symptoms are:
1. Fever (high degree)
2. Watery diarrhea
3. Vomiting within few hours of measles vaccination.

Case fatality rates are high. May cause death within 48 hours.
Combined Vaccine
It can be combined with other live attenuated vaccines such as mumps
and rubella vaccines (MMR vaccines) and such combinations are highly
effective.
Immunoglobulin
Measles may be prevented by administration of immunoglobulin early
in the incubation period, the dose recommended by WHO is 0.25 ml per
kg of body weight. It should be given within 3 to 4 days of exposure.
The person passively immunized should be given live measles vaccine
8 to 12 weeks later.
Eradication is possible because:
1. Highly potent vaccine is available
2. Need a single dose of vaccine
3. Vaccine can be stored for long time and gives long lasting immunity
4. Case detection and surveillance is possible
5. By primary health care approach-universal immunization program
facilities are made available even in remote areas.
Urban Measles Campaign

Measles is a highly contagious viral disease occurring in overcrowded
areas where poor people live and coverage of measles vaccination is
poor. These areas are needed special vaccination drive initiated by
UNICEF in 1998 covering 13 cities and in 1999-2000, 50 more cities are
also covered. The main focus is on covering all unprotected children up
to the three years.
Diphtheria Immunization
Current prophylactics. These may be grouped as below:
Combined or Mixed Vaccines

DPT (Diphtheria, pertussis-tetanus vaccine)
DT (Diphtheria and tetanus toxoid)
dT (Diphtheria and tetanus, adult type).
Single Vaccines
FT (Formal toxoid)
APT (Alum-precipitated toxoid)
Immunization 179
PTAP (Purified toxoid aluminum phosphate)

PTAH (Purified toxoid aluminum hydroxide)
TAF (Toxoid-antitoxin floccules).
Antisera
Diphtheria antitoxin
Combined vaccines DPT vaccine.
Advantages
1. The infant can be immunized simultaneously againstthree diseases
viz. diphtheria, pertussis and tetanus.
2. Pertussis component enhances the potency of the diphtheria toxoid.
Two types of vaccinesplain and adsorbed. Adsorbtion is carried
out on a mineral carrier like aluminum phosphate or hydroxide.
Composition of DPT Vaccines (Table 8.4)

Table 8.4: Composition of DPT vaccines
Contents Glaxo (Per/0.5ml) Kasauli
Diphtheria toxoid 25 Lf 30 Lf
Tetanus toxoid 5 Lf 10 Lf
B. pertussis (millions) 20,000 32,000
Aluminum phosphate 2.5 mg 3.0 mg
Thiomersal, BP 0.01% 0.01%
Storage
Vaccines should not be frozen. They should be stored in a refrigerator
between 4 to 8C.
Optimum age is six weeks after birth
No of doses: 2-3 doses
Two dose of DT gives > 80 percent protection
But two doses of pertussis gives50 percent protection
Three dose of DPT offers better protection than two doses of DPT.
Interval between Doses
An interval of four weeks between three doses with a booster injection
at 1-2 years followed by another booster dose (DT only) at age five to
six years.
Mode of Administration
Deep IM upper outer quadrant of the gluteal region.
In 1984, Global Advisory Group recommended DPT vaccine for
children under one year of age, DPTshould be administered in lateral
aspect of thigh.
Reactions
Fever and mild local reactions are common two to six percent of vaccinees
develop fever of 39C or higher 5 to 10 percent experience swelling and
induration or pain lasting more than 48 hours.
Neurological Complications
These are due to the pertussis component of the vaccine.
Encephalitis
Encephalopathy
Prolonged convulsions
Infantile spasms
Reyes syndrome.
Contraindications
Minor illness such as cough, cold, mild fever are not considered contra-
indications to vaccination.
DPTshould not be repeated if a severe reaction occurred after a
previous dose.
Such reactions include collapse or shock like state, persistent screaming
episodes, temp > 40C, convulsions, anaphylactic reaction. In case of
DPT subsequent immunization with a DT only is recommended without
pertussis component.
Tetanus Toxoid
1. Active immunization
2. Passive immunization.
Aim
Protective level of antitoxin approximately0.01 IU/ml serum throughout
life.
All persons should be immunized regardless of age.
Two Preparations
1. Combined vaccine-DPT
2. Monovalent vaccines
a. Plain or fluid (formal) toxoid
b. Tetanus vaccine, adsorbed (PTAP, APT).
Monovalent
0.5 ml injected into armone to two months interval
First booster doseone year after the initial two dose
Second booster dosefive year after 3rd dose
Immunization 181
It can be stored up to 5 hours at 4 to 10C

It must not be allowed to freeze at any time.
All wounds should receive surgical toilet (Flow chart 8.3)
Flow chart 8.3: All wound receive surgical toilet
A = Has had a complete course of toxoid or a booster dose within the past five
years.
B = Has had a complete course of toxoid or a booster dose more than five years
ago and less than 10 years ago.
C = Has had a complete course of toxoid or a booster dose more than 10 years ago.
D = Has not had a complete course of toxoid or immunity status is unknown.
Passive Immunization
Temporary protection against tetanus can be provided by injection of
Human tetanus hyperimmunoglobulin or ATS.
It is best prophylactic to use. The dose for all ages is 250-500 IU. It
does not cause serum reactions. It gives longer passive protection up to
30 days or more compared to 7 to 10 days for Horse ATS. Human tetanus
Ig is now available in India and it is produced by the Serum Institute of
India, Pune.
ATS (Equine)
If human antitoxin is not availableequine antitoxin (ATS) is used. The
dose is 1500 IU-SC after sensitivity testing.
Gives passive protection for about 7 to 10 days.
Being foreign protein ATS is rapidly excreted from the body and
there may be very little antibody at the end of two weeks.
Therefore, it does not cover the tetanus incubation period (IP) in all
cases. It causes sensitivity reaction in many cases. Person receiving first
time may toleratesubsequent injection with horse serum may lead to
allergic reaction varying in severity from rash to anaphylactic reaction.
It stimulates formation of antibodies.
Active and Passive Immunization
The patient is given:
1500 IU of ATS or 250-500 IU Human Ig in one arm, and
0.5 ml of adsorbed TT (PTAP or APT) into other arm or gluteal region
Booster dose aftersix weeks later (0.5 ml), and
Third doseone year later.
Elimination of Neonatal Tetanus
Neonatal tetanus is still a common problem in many districts. Fortunately
this disease can be eliminated by immunising all women in reproductive
age group with tetanus toxoid. The National Program of Elimination of
Neonatal Tetanus includes:
Reducing the incidence to less than 1 case per 1000 live births by 1995
and later it was extended to 2000
Component of RCH
Interventions:
1. Coverage of all pregnant women with two doses of tetanus toxoid
2. Extensive IEC efforts to promote clean deliveries: Five Cleans
Clean Hands, Clean Surface, Clean Blade, Clean Stump, and Clean
Tie.
3. Providing disposable delivery kits.
4. Community based surveillance of neonatal deaths and investigation
and control measures in case of neonatal deaths.
Anti-rabies Vaccine (Table 8.5)
Table 8.5: Dosage schedule

Class Adult Children Duration Booster dose (Bd)
Treatment recommended by Central Research Institute Kasauli
Class I 2 ml 2 ml 7 days No
Class II 5 ml 2 ml 10 days 1 Bd to be given 3 weeks or
later after 10th inj.
Class III 5 ml 2 ml 10 days 1st Bd 7 days after 10th inj
2nd Bd 2 weeks or later
after 1st Bd
Recommended by Pasteur Institute Coonoor
Class I 2 ml 1 ml 7 days No
Class II 3 ml 3 ml 10 days
Class III 5 ml 3 ml 10 days
Immunization 183
Cell Culture Vaccine

Six doses 1 ml each on days0, 3, 7, 14, and 28
Bd on day 90. Injected IM on deltoid muscle.
Multisite schedule
Reduced multisite in regimen (2-1-1) (0.5/ml)
(0.5/1 ml) deltoid
2-1-1 regimen on days 0-7- 21
Intradermal (Id): 2 Site regimen (2-2-2-0-1-1) on days 0, 3, 7, 28 and
90 dose: 1 Id dose = 1/5th of IM dose (1.0 or 0.5 ml) Id per site
Intradermal regimen: 8 Site (8-0-4-0-1-1) on days 0,7,28,90 dose
1/5th of IM dose.
Pre-exposure Prophylaxis
Cell culture vaccine is given either as 1 ml IM of 0.1 ml Id on days, 0.7
and 28.
If serum titers of virus neutralizing antibodies are less than 0.5 IU/ml,
booster doses of 1 ml IM or 0.1 ml intradermally should be administered
until antibodies become demonstrable. Further booster injections should
be administered at intervals of two years as long as exposed person
remains at risk.
Re-exposure to Animals after Anti-rabies Vaccination

Re-exposure after six months of completion of course of anti-rabies
vaccination (with nervous tissue vaccine). It should be considered as
fresh case.
Re-exposure within six months:
Class I risk within 6 month1 Bd 2 ml vaccine
Class I infected by class II and III wound
Full course vaccine to be given.
If Patient has been treated earlier for class II and III wound next
exposure is also same class2 Bd of 5 ml1st dose immediately and
2nd dose after a week.
In tissue culture vaccineRe-exposure after 5 years should be treated
as fresh case.
Re-exposure within 5 years: 2 BdSpaced a week apart
No anti-rabies serum indicated up to 5 years following primary
immunization.
Adverse Reactions
General: Headache, insomnia, giddiness, palpitation
Local: Pain, tenderness, redness swelling
Allergic: Urticaria, syncope, angioneurotic edema
Neuroparalysis: Post-vaccinal paralysis due to sensitization
Advice to Patients
1. They should abstain from alcohol during and one month after
completion of anti-rabic Rxit may facilitate paralytic accident.
2. Undue physical and mental strain should be avoided
3. Corticosteroid and other immunosuppressive agent should not be used
4. Rabies may develop following inadequate immunization.
Anti-Snake Venom
Polyvalent anti-snake venom serum should be given to neutralize the
poison.
Serum should be injected soon after the bite
20 ml is given IV after test dose
Repeated after one hour or even earlier
If symptoms persist, further dose repeated every sixth houruntil
symptoms disappear completely.
Prepared by
Hyper immunizing horse againstvenom of four common poisonous
snake, i.e. cobra, common krait, russels, viper (saw scaled viper).
Plasma obtained from hyperimmunized horses is concentrated and
purified.
Serum is lyopolised by drying it from frozen state under high vaccum.
It is prepared in Haffkins Institute, Bombay and Kasauliin India
Available in the form of lyopolized powder in an ampoule, dissolved
in distilled water before being injected.
It is useful when given within 4 hours, doubtful value after24 hours
Serum will produce serum sickness and even acute anaphylaxis in
sensitive persons
To test the sensitivity
0.05 to 0.1 ml in 1:10 dilution of serum is injected intradermally. +ve
reactionwheal 1 cm surrounded by erythema of same width develop
in 5 to 20 minutes
For desensitization1/2 to 1 ml of antiserum is injected subcutaneously
40 ml of anti-venom is given IV and repeated as required. It is effective
for cobra and russel
In case of viper biteinject anti-snake venom around to the site of
bite
If there are signs of neuroparalysisgive 1/2 mg neostigmine 1/2 hr
before each injection 1/2 mg atropine should be given to block
muscarinic side effects of neostigmine
Heparin 1000 to 5000 IU if clotting abnormality is present
Inject TT
Broad spectrum antibiotics.
Immunization 185
Newer Vaccines
HIV Vaccine
There are three different approaches to HIV vaccination:
Preventive vaccine: To prevent HIV-negative persons from being infected.
Perinatal vaccine: To vaccinate HIV-infected pregnant women, in order
to protect the fetus or the newborn child from being infected.
Therapeutic or post-infectious vaccine: To delay the progression to AIDS
in HIV-positive persons.
Leprosy Vaccine
Three leprosy vaccines are currently undergoing large scale human trials.
The first is the WHO vaccine developed by Dr J Convict in Venezuela. It
is a combined vaccine containing BCG and heat killed M. leprae, harvested
from armadillo. The rationale for incorporating BCG in it is the fact that
BCG has some protective action against leprosy. The other two are
Indian vaccinesthe ICRC vaccine developed by Dr MG Deo at Cancer
Research Institute, Mumbai and the MW vaccine, developed by Dr GP
Talwar at National Institute of Immunology, New Delhi from Mycobact.
W, which is a nonpathological atypical Mycobacterium sharing antigens
with M. leprae.
Chickenpox Vaccine
A live attenuated vaccine (OKA strain) developed by Takashasi in Japan
has been extensively studied in field trials. The frequency of mild local
reactions at the site of inoculation is about one percent. A general reaction
to the vaccine, after vaccination, in healthy seronegative children is over
90 percent. The vaccine has proved safe and effective in preventing the
disease.
Rubella Vaccines
In 1979, the RA 27/3 vaccine, produced in human diploid fibroblast has
replaced all the other vaccines. This is because RA 27/3 vaccine induces
higher antibody titers and produces an immune response more closely
paralleling natural infection than the other vaccines. There is evidence
that it largely prevents subclinical superinfection with wild virus.
RA 27/3 vaccine is administered in a single dose of 0.5ml subcutaneously.
It may provoke mild reactions in some subjects such as malaise,
fever, mild rash and transient arthralgia, but no serious disability.
Seroconversion occurs in more than 95 percent vaccinees. Vaccine-induced
immunity persists in most vaccinees for at least 14 to 16 years and
probably is lifelong.
MMR: Rubella vaccine is also available as combined measles, mumps

and rubella (MMR) vaccine. It is equally effective. It is given at 15 months
of age in a dose of 0.5 ml intramuscularly/subcutaneously.
Influenza Vaccines
Split-virus vaccine: Also known as sub-virion vaccine. It is a highly purified
vaccine, producing fewer side effects than the whole virus vaccine.
Because of its lower antigenicity, it requires several injections instead of
a single one. It is recommended for children.
Neuraminidase specific vaccine: It is a sub-unit vaccine containing only the
N antigen, which induces antibodies only to the neuraminidase antigen
of the prevailing influenza virus. Antibody to neuraminidase reduces
both the amount of virus replicating in the respiratory tract and the
ability to transmit virus to contacts. It significantly reduces clinical
symptoms in the infected person, but permits subclinical infection that
may give rise to lasting immunity.
Recombinant vaccine: By recombinant techniques, the desirable antigenic
properties of a virulent strain can be transferred to another strain known
to be of low virulence. Effort to improve influenza vaccine are continuing
in several directions.
Hepatitis B Vaccines
Active immunization can be done using a vaccine prepared from plasma
of HbsAg carriers. The whole virus is removed and inactivated with
formalin. It is available as Hepativax-B (MSD) and Hevac-B (Pasteur) and
is indicated only for high-risk groups.
A 3 ml vial of Hepativax-B contains 20 micrograms of the vaccine.
Recent observations suggests as the routine higher dose and provides
protection for 5 years. The use of this smaller 0.1 ml dose considerably
lowers the cost of immunization (Table 8.6).
Table 8.6: Hepatitis B vaccineimmunization schedule
1st dose 1 ml at selected date
2nd dose 1 ml 1 month later
3rd dose (booster) 1 ml 6 months after the first dose
Note: Children under 10 years of age should be given half of above dosage at the same time
intervals.
rDNA-yeast derived vaccine: A subunit HbsAg containing vaccine made

by recombinant DNA (rDNA) technology is also available. It is costlier
but safer. The reason is that the plasma derived vaccine carries the risk
of infection, especially AIDS. A combination of DPT with HB vaccine is
also available.
Immunization 187
Malaria Vaccines
Asexual blood-stage vaccines based on antigens derived from the blood

states of P. falciparum present in man. These vaccines are designed to
reduce severe and complicated manifestations of the disease.
A synthetic cocktail vaccine for P. falciparum, called SPf 66 is developed
by Dr M Patarroyo in Colombia. It reduces the risk of developing clinical
malaria by about 30 percent.
Pfs25 vaccine: As far as transmission blocking vaccines are concerned,
Pfs25 is a leading candidate and a preparation based on it has gone into
clinical trials in the USA and Africa during 1995.
Meningococcal Vaccines
Effective vaccines prepared from purified Group A, Group C, Group
Y, and/or Group W135 meningococcal polysaccharides are now available.
They may be monovalent (A or C) or polyvalent (A-C; A-C-Y, etc). Recent
field trails have indicated that immunity lasts for about three years, and
boosters every three years would be reasonable. High-risk population
should be identified and vaccinated. The vaccine is not recommended
for use in infants and children under two years. The vaccine is contraindicated
in pregnant women.
BIBLIOGRAPHY
1. Ann Rev of PH 1988; 209.
2. Desai HG. Prevention and Control of Hepatitis B virus. Medical times
(sandoz)1984;14:4.
3. Jawetz E, et al. Review of Medical Microbiology, 14th edn, Lang Med Pabl
California, 1980.
4. Kallings LO. CARC Calling 1993; 6:(1) 3-5.
5. Ministry of Health and Family Welfare Govt. of India New Delhi. Conduct
immunisation, 1989.
6. National Health Programmes of India, J Kishore 4th edn, 2002.
7. Pan American Health Organisation. Bull PAHO 1978;12(2):162.
8. Parks Textbook of PSM, 16th edn, 2000.
9. Peckham CS. Med Int 1988;51:2107.
10. Textbook of PSM, MC Gupta and BK Mahajan, 3rd edn, 2003.
11. Wahdan MH, et al. Bull WHO 1973;48:667-73.
12. Wahdan MH, et al. Bull WHO 1977;55:645-51.
13. WHO. Tech RCP Ser No. 693,1983.
14. WHO. Tech RCP Ser No. 771,1988.
15. WHO. The World Health Report 1995 Bridging the gaps, Report of the
Director General WHO,1995.
Chapter
9 Nutrition
CHAPTER OUTLINE
BALANCED DIETS
INTRODUCTION
The importance of nutritional support was realized in the late 1970s.
Nutritional support is not merely administering calories and proteins, it
also includes the provision of all nutritional substrates to facilitate the
biological processes of inflammation and healing.
Dietetics
Dietetics is the practical application of principles of nutrition for the well
and sick persons.
Balanced Diet
A balanced diet is defined as one which contains a variety of foods in
such quantities and proportions that the need for energy, amino acids,
vitamins, minerals, fats, carbohydrate and other nutrients is adequately
met for maintaining health, vitality, and general well-being and also makes
a small provision for extra nutrients to withstand short duration of
leanness.
An Indian Reference Man

An Indian reference man is between 20 and 39 years of age and weighs
60 kg (Tables 9.1 and 9.2). He is free from disease and physically fit for
active work. On each working day he is employed for eight hours in
occupation that usually involves moderate activity, while not at work he
spends eight hours in bed, four to six hours sitting and moving around
and two hours in walking and in active recreation or household duties.
An Indian Reference Woman

An Indian reference woman is between 20 and 39 years of age, healthy
and weighs 50 kg (Tables 9.1 and 9.2). She may be engaged for eight hours in
Nutrition 189
general house hold work, in light industry or in other moderately active

work. Apart from eight hours in bed, she spends four to six hours sitting
or moving around only through light activity and two hours in walking
or in active recreation or in household duties.
Table 9.1: Indian reference men and women

Reference man Reference woman
1. Age 20-39 years 20-39 years
2. Weight 60 kg 50 kg
3. Household works 8 hours 8 hours
4. Sleep 8 hours 8 hours
5. Light activity 4-6 hours 4-6 hours
6. Active recreation (walking) 2 hours 2 hours
Table 9.2: Appropriate body weights for men and women

Men Women
Height (cm) Average (kg) Acceptable Average Acceptable
range (kg) range (kg) range (kg)
145 46.0 37.53
148 46.5 37.54
150 39.58 47.0 38.55
152 40.59 48.5 39.57
156 43.62 49.5 39.58
158 55.8 44.64 50.4 40.58
160 57.6 44.65 51.3 41.59
162 58.6 46.66 52.6 42.61
164 59.6 47.67 54.0 43.62
166 60.6 48.69 55.4 44.61
168 61.7 41.71 56.8 45.65
170 63.5 51.73 58.1 45.66
172 65.0 52.74 60.0 46.67
174 66.5 53.75 61.3 48.69
176 68.0 54.77 62.6 49.70
178 69.4 55.79 64.0 51.72
180 71.0 58.80 65.3 52.74
182 72.6 59.82
184 74.2 60.84
186 75.8 62.86
188 77.6 64.88
190 79.3 66.90
192 81.0 68.93
The dietary sources of energy are:

Protein 4 kcal/gm
Fat 9 kcal/gm
Carbohydrate 4 kcal/gm
Macronutrients: These are proteins, fats and carbohydrates. These are also
called as proximate principles which form the major bulk of food.
Micronutrients: These are vitamins and minerals. They are required in very
small quantities.
Energy expenditure for work:
Persons require energy for daily activitiessitting, standing, walking,
talking.
Male: 1250 kcal for 8 hours of work
Female: 820 kcal for 8 hours of work
Energy requirements: Energy requirements for persons doing
1. Light work 1.7 kcal/kg/hr
2. Moderate work 2.5 kcal/kg/hr
3. Heavy work 5 kcal/kg/hr
Energy requirement decreases as age advances, after 40 years, there
is 5 percent decrease per decade up to 60 years, another 10 percent decrease
during 60-70 years and further 10 percent decrease after
70 years of age.
Nutrition: Nutrition signifies a dynamic process in which the food that is
consumed is utilized in the human body for nourishment.
Nutrient: Chemical compounds found in food which are needed for the
body.
Meal: It is sum of the total food ingested at one feeding.
Diet: It is sum of the meals per day.
Dietary: It is the prescription of course of diet.
Food: It is composite mixture of various substances in various quantities.
Foodstuff: Anything which can be used as food is foodstuff.
Assessment of Nutritional Status

The assessment of nutritional status involves various techniques. Proper
evaluation demands many angled approach.
The assessment method includes:
1. Clinical examination
2. Anthropometry
3. Biochemical evaluation
4. Functional assessment
5. Assessment of dietary intake
6. Vital and health statistics
7. Ecological studies
8. Weighment of raw food
Nutrition 191
9. Weighment of cooked food

10. Oral questionnaire method
11. Mortality data
12. Morbidity
13. Food balance sheet
14. Socioeconomic factors
15. Health and educational services
16. Conditioning influences.
Assessment of the Energy Requirement for Family

The recommendation co-efficients for calculating energy need of different
members of the family are given in Table 9.3.
Table 9.3: Assessment of the energy requirements of a group of family
Category Co-efficient
(for calculating energy requirements)
Adult male (sedentary worker) 1.0
Adult male (moderate worker) 1.2
Adult male (heavy work) 1.6
Adult female (sedentary) 0.8
Adult female (moderate worker) 0.9
Adult female (heavy worker) 1.2
Adolescents12 to 21 years 1.0
Children9 to 12 years 0.8
Cereals and Millets

In India, cereals like wheat, rice and maize form the staple food of people.
Millets (smaller grains that are eaten without removing the outer layer)
are also used to fair extent by same segment of the population. More
common among the millets are jawar and bajra.
Cereals and millets are rich in carbohydrates and sources of dietary
protein. They are a good source of minerals and several B complex vitamins
(Table 9.4).
Milling Process Deprives

Thiamine15 percent
Riboflavine75 percent
Protein60 percent
Washing and cooking60 percent loss of water soluble vitamins.
Table 9.4: Food value per 100 g

Cereals Carb- Fat Protein Calcium Iron Energy Limiting
name of ohyd- (gm) (gm) (mg) (mg) (kcal) amino acid
foodstuff rates
(gm)
Jawar 72.6 1.9 10.4% 25 4.1 349 Lysine and
threonine
Bajra 67.5 5 11.9 42 8 361
Ragi 72 1.3 7.3 344 3.9 328
Maize 66.2 3.6 11.1 50 3.8 342 Tryptophan and
(dry) lysine
Wheat 71.2 1.5 11.8 50 5.3 346 Lysine and
(whole) threonine
Rice 78.2 0.5 6.8 23 6.6 345 Poor source of
(row, milled) A1, C and D vitamins
Parboiling
Process starts with soaking the paddy in hot water at 65 to 70C for three
to four hours which swells the grain. This is followed by draining of
water and steaming the soaked paddy in same container for 5 to 10
minute. The paddy is then dried and home pounded or milled. During
steaming, greater part of vitamins and minerals present in outer aleurone
layer of rice grain are driven into the inner endosperm. With subsequent
drying process the germ get attached more firmly to the grain. It results in
the grains becoming resistant to insect invasion and more suitable for
storage than raw rice. The starch also get gelatinized which improves
keeping qualities of rice.
Pellagra
It is a nutritional deficiency disease. High leucine content in jawar and
maize interferes in the conversion of tryptophan into niacin and thus
aggravates the pellagragenic action of maize and jawar.
Pellagra manifestations3Ds
Diarrhea
Dementia
Dermatitis
Pulses (Legumes)
Pulses are called poor mans meat. In fact pulses contain more protein
than egg, fish and flesh food, but in regards to the quality, pulses protein
is inferior to animal protein. Pulses are poor in methionine and to a lesser
extent in cystein and are rich in lysine (Table 9.5).
Soyabean is exceptionally rich in protein, containing up to 40 percent.
Nutrition 193
Table 9.5: Nutritive value of pulses

Food Energy Protein Fat Carbo- Iron Thia- Ribo- Niacin Vit
stuff (kcal) (gm) (gm) hydrate (mg) mine flavin mg C
Bengal 360 17.1 5.3 202 4.6 0.30 0.15 2.9 0
gram (whole)
Black 347 24.0 1.4 154 3.8 0.42 0.20 2.0 0
gram (dhal)
Red 335 22.3 1.7 73 2.7 0.45 0.19 2.9 0
gram (dhal)
Soya 432 43.2 19.5 240 10.4 0.73 0.39 3.2 0
bean
Germination and Fermentation

The simple measures of soaking pulses in water for 2 to 3 hours improves
their nutritive value and vitamin A and vitamin C content.
Germination increases the content of folic acid and other vitamin B group
by a factor of two or three. Pulses contain an antidigestive factor (trypsin
inhibitor) which is destroyed by cooking.
Anti-nutritional factors: In the raw state, pulses have some anti-nutritional
factors such as phytate and tannins most of anti-nutritional factors
destroyed by heat.
Presence of certain sugar known as oligosaccharides is known to be
associated with flatulence.
Lathyrism
Lathyrism is a paralyzing disease of human and animal, occuring mostly
in adults consuming the pulse, lathyrus sativus in large quantity (more
than 30% of this dhal over a period of 2-6 months).
In humans it is referred to as neurolethyrism.
In animals it is referred to as osteolethyrism.
Toxin present in lathyrus seeds has been known as (Beta-oxalyl amino
alanine) BOAA .
Manifestation (in Different Stages)

1. Latent stage
2. No stick stage
3. One stick stage
4. Two stick stage
5. Crawler stage.
Intervention
1. Vitamin C prophylaxis
2. Banning the crop
3. Removal of toxin
a. Steeping method
b. Parboiling
4. Education
5. Genetic approach.
Vegetables
Vegetables are classed as protective foods
Vegetables are divided into:
1. Green leaves
2. Roots and tubers
3. Other vegetables.
Leafy vegetables are high in water content and dietary fiber. These
vegetable contain a high proportion of cellulose, which human intestinal
juices (unlike those of herbivorous animals) can not digest. It thus remains
unabsorbed and increase bulk of the intestinal contents.
The bioavailability of calcium and iron from green vegetables is rather
poor because of the presence of high amount of oxalates.
Dont soak cut leaves for a long time, by doing so water soluble vitamins
B and C will be dissolved in water and are wasted.
Addition of baking powder will not only destroy the flavor and texture
but vitamin B will also be lost.
Dont cook in excess water, avoid over cooking and reheating to avoid
vitamin C loss.
The recommended daily intake of green leafy vegetables is about 40 gm
for an adult.
Fruits (Fructuato Enjoy)

Fruits are protective foods.
The costly fruits are not necessarily the best one. Banana is the cheapest
when considered as a food rather than a fruit. Grape and apple are not of
high nutritional value.
Composition of Fruits per 100 gm (Table 9.6)
Clinical use
Banana
a. Acts as a mild laxative
Nutrition 195
Table 9.6: Composition of fruits per 100 gm

Fruits Protein Fat Carbohydrate Vit A Vit C Caloric
(gm) (gm) value
Apple 0.2 0.5 13.4 Trace 2 59
Banana 1.2 0.3 27.2 Trace 1 116
Grapes (pellagra) 0.5 0.3 16.5 15 31 71
Mango 0.6 0.4 16.9 800 13 74
Papaya (ripe) 0.6 0.1 7.2 2020 46 32
Jack fruit 1.9 0.1 19.8 540 10 88
Lemon 1.0 0.9 11.1 0 39 57
b. A high-banana diet probably increases the butyric acid concentration

in intestine and this may control diarrhea.
c. Steamed banana leaves are effectively used for dressing burn wounds.
Mango
a. Eating mangoes in season may provide a store of vitamin A in the
liver, sufficient to last for the rest of the year.
Papaya
a. Papaya can be prescribed for dyspeptic patients as the pepsin may help
in the digestion of proteins.
b. Papaya seeds have an antihelminthic action.
c. A protein digestive enzyme chymopapain derived from papaya is used
as injection into herniated intervertebral lumbar disks to relieve pain
caused by pressure on nerves.
Nuts and Oil Seeds

The common nuts consumed in the tropics are coconut, groundnut, cashew
nut, almonds and pista.
They are rich in proteins, fat, carbohydrates, minerals, and factors of
vitamin B complex. Nuts approach on ideal food by supplying high
calories in a palatable form. Groundnut is palatable and cheapused in
multipurpose food Balahar, used as balanced malt food due to high fat
content and partly cellulose content.
Aflatoxin: Stored groundnut may be contaminated with the fungus
Aspergillus flavors which produce toxins known collectively as aflatoxins.
Sweet Food and Sweetening Agents

Sugar is almost pure sucroseA diasaccharides made up of glucose and
fructose (levulose). One gm of sugar supplies4 kcal.
One teaspoonful (5 g) gives20 kcal.
The average consumption of sugar is well over 100 gm a day per person.
Honey: Golden colored syrup made by bees from the nectar of flowers
which contains mixture of glucose and fructose which gives it a particular
sweetness.
Composition
Glucose25 to 37 percent
Fructose34 to 43 percent
Sucrose0.5 to 12 percent
Maltose5 to 12 percent
100 gm honey provides288 Kcal
Honey may contain the bacteria Clostridium botulinum which may
produce infant botulism.
1. Honey 50 mg/liter recommended instead of sugar in oral rehydration
fluid.
2. Honey in warm water or milk can be a soothing drink for patients with
pharyngitis and tracheitis.
Nutrient Requirements during Pregnancy (Tables 9.7 to 9.14)

Table 9.7: Daily allowances for nutrients for expectant and nursing mothers
(ICM R Nutrition Export Group, 1998)
Nutrient Sedentary Moderate Heavy Pregnancy Lactation
work work
Calories (kcal) 1900 2200 3000 +300 +700
Proteins (g) 45 45 45 55 65
Calcium (g) 0.45-0.5 0.4-0.5 0.4-0.5 1.0 1.0
Iron (g) 30 30 30 40 30
Vitamin (A)
as Retinol (g) 750 750 750 750 1150
Or
as Carotene (mg) 3000 3000 3000 3000 4600
Thiamine (mg) 1.0 1.1 1.5 +0.2 +0.4
Riboflavin (mg) 1.0 1.2 1.7 +0.2 +0.4
Nicotinic acid (mg) 13 15 20 +2 +5
Ascorbic acid (mg) 50 50 50 50 80
Folic acid (mg) 100 100 100 150-300 150
Vitamin B12 (mg) 1.0 1.0 1.0 1.5 1.5
Vitamin D (IU) 200 200 200 200 200
Table 9.8: Suggested substitution for nonvegetarians

Food item which can be deleted from non- Substitution that can be suggested for
vegetarian diets deleted item or items
1. 50% of pulses 1. One egg or 30 g meat or fish
(20-30 g) 2. Additional 5 g fat or oil
2. 100% of pulses 1. Two eggs or 50 g of meat or fish,
(40-60 g) one egg plus 30 g meat
2. 10 g of fat or oil
Nutrition 197
Table 9.9: Additional allowances during pregnancy and lactation

Food items During Calories During Calories
pregnancy (kcal) lactation (kcal)
Cereals 35 g 118 60 g 203
Pulses 15 g 52 30 g 105
Milk 100 g 83 100 g 83
Fat 10 g 90
Sugar 10 g 40 10 g 40
Total 293 521
Diet: For a child suffering from protein calorie malnutrition and weighing
12 kg, the daily calorie intake should be about 12 140 = 1680 kal and
protein intake should be 12 4 or 5 = 48 to 60 g.
Table 9.10: Diet for a child suffering from kwashiorkor or marasmus
(Body wt 12.12 kg calories 1700 kcal protein 50-60 g)
Foodstuffs Diet for Ist to 10th day Diet for 11th to 30th day
Milk, skimmed (ml) 1000
Milk, skimmed (ml) 1000 2000
Cane sugar (g) 100 100
Dextrimaltose (g) 50
Ripe banana (two) (g) 150 150
Corn or wheat flour (g) 25 50
Bread and biscuit (g) 25 10-100
Vitamins Daily requirements added to milk
Table 9.11: Daily menu for a child suffering from kwashiorkor or marasmus
1st day to 10th day 11th day to 30th day
Morning 6.00 am Morning 6.00 am
Milk (half fat) Milk (full fat)
With sugar1 cup With sugar1 cup
Breakfast 8.00 am Breakfast 8.00 am
Corn flour milk pudding1 serving Bread (1 slice) with milk
Banana (one) Banana (one)
Milk with sugar1 cup Corn flour milk pudding1 serving
Milk with sugar1 cup
10.00 am 10.00 am
Milk with sugar1 cup Milk with sugar1 cup
1.00 pm (lunch) 1.00 pm (lunch)
Bread soaked in milk1 slice Bread2 slices (with milk)
Banana1 Banana1
Milk with sugar1 cup Milk pudding1 serving
4.00 pm 4.00 pm
Biscuit 2
Contd...
Contd...
1st day to 10th day 11th day to 30th day
7.00 pm (Dinner) 7.00 pm (Dinner)
Bread soaked in milk1 slice Same as lunch
Banana1
10.00 pm 10.00 pm
Table 9.12: Daily menu for adults suffering from tuberculosis

Vegetarian Nonvegetarian
Early morning
Breakfast
Bread4 slices or Bread4 slices or

Idli4 or Idli 4 or
Dosa2 or Dosa2 or
Poori3 Poori3
Cheese1 slice Boiled egg1
Nuts2 tablespoons Nuts2 tablespoons
Mid-morning
Fruit juice1 glass Fruit juice1 glass
Lunch
Cooked rice or chappati1 serving Cooked rice or chappati1 serving
Vegetable curry1 serving Mutton or fish curry1 serving
Dal soup1 cup Vegetable curry1 cup
Curd1 cup Dal soup1 cup
Milk pudding1 serving Milk pudding1 serving
Fruits1 serving Fruits1 serving
Mid-afternoon
Fruit juice1 glass Fruit juice1 glass
Tea
Biscuits2 Biscuits2
Nuts2 tablespoons Nuts2 table spoons
Cheese1 slice Cheese1 slice
Fruits1 serving Fruits1 serving
Dinner
Same as lunch
Nutrition 199
Table 9.13: Diet in severe jaundice in viral hepatitis for an adult (g/caput/day)
Proteins, 40-45 g; Fats 25-30 g; Carbohydrates 300-340 g

and Calories 1600-1700 Kcal
Cereals 200
Skimmed milk 500
Potato 100
Leafy vegetables 50
Fruits (apple, mango, papaya or banana) 200
Fruit juice 600
Fat and oils 15
Sugar and Jam 60
One multivitamin tablet providing the daily requirements of all vitamins should be included along
with the diet.
Table 9.14: Daily menu for severe jaundice
Morning
Fruit juice 1 glass
Breakfast
Corn flakes with skimmed milk and sugar 1 serving
Toast with a little butter and jam 2 slices
Fruits 1 serving
Tea or coffee 1 cup
Mid morning
Fruit juice 1 glass
Lunch
Cooked rice or bread or chappati 1 serving
Vegetable soup 1 cup
Cooked vegetables 1 serving
Fruits 1 serving
Skimmed milk pudding 1 serving
Tea
Biscuits 2
Fruit juice 1 glass
Dinner
Similar to Lunch
Rich Sources of Essential Nutrients

Richest source of poly unsaturated fatty acid: Safflower oil75 percent.
Richest source of saturated fatty acid is coconut oil92 percent.
Richest source of Linoleic acid (EFA) is safflower oil73 percent.
Richest source of vitamin A (retinol) is Halibut liver oil(900,000 mcg/
100 g) and cod liver oil (18000 mcg/100 g).
Green leafy vegetable rich in vitamin A (Carotene) is Colocasia
leaves12000 mcg/100 g. Others are Amaranth, Spinach.
Vegetable rich in vitamin A is carrot1167 mcg/100g.

Fruit rich in vitamin A is Ripe mango.
Richest source of vitamin D is halibut liver oil (50-10,000 mcg/100 g)
and cod liver oil.
Thiamine rich foodswheat, rice parboiled, bengal gram dhal,
gingelly seeds.
Rich source of riboflavin in sheep liver1.70 mg/100 mg.
Rich source of niacin-ground nut (22.1/100 g), sheep liver.
Fruits rich in vitamin Camla (600 mg/100 g), guava (212).
Pulse with high vitamin Ccontent bengal gram.
Vegetables rich in vitamin Camaranth (99), cabbage (124).
Rich source of calciumragi (344 g/100 g).
Protein Requirements
Men and women 1 gm/kg/day
Infants (0-6 mon) 1.8-2.3
Infants (6-9 mon) 1.65
Children (1-6 years) 1.52-1.83
Children (6-9 years) 1.48
Adolescent males 1.3-4.6
Adolescent females 1.21-1.45
Principles in Calculating Balanced Diet

India
Energy from cereals not to be more than 75 percent.
Cereal protein to pulse protein ratio to be kept at 4:1.
Vegetables to constitute 80 gm.
Inclusion of green leafy vegetables.
Minimum milk intake of 100 ml needed.
Fat not to contribute more than 15 percent of energy.
Energy from refined carbohydrates kept around 5 percent and total
calories from sugar not to exceed 20 percent.
BALANCED DIETS (TABLE 9.15)

Table 9.15: Balanced diets (The quantities are given in grams)
Adult man Adult woman

Food items Sedentary Moderate Heavy Secondary Moderate Heavy
worker worker worker worker worker
Cereals 460 520 670 410 440 575
Pulses 40 50 60 40 45 50
Leafy vegs 40 40 40 100 100 50
Other vegs 60 70 80 40 40 100
Roots and tubers 50 60 80 50 50 60
Milk 150 200 250 100 150 200
Oils and fats 40 45 65 20 25 40
Sugar 30 35 55 20 20 40
Nutrition 201
Balanced Diet for Children (Table 9.16)

Table 9.16: Balanced diet for children
Children Children Boys Girls

Food items 1-3 years 4-6 years 10-12 years 10-12 years
Cereals 175 270 420 380
Pulses 35 35 45 45
Leafy vegs 40 50 50 50
Other vegs 20 30 50 50
Roots and tubers 10 20 30 30
Milk 300 250 250 250
Oil and fats 15 25 40 35
Sugar/jaggery 30 40 45 45
Food items Approx Approx Protein Calories
Quantity Weight (gm) (gm)
Musambi 1 average 150 1.2 63
Watermelon 100 0.5 28
Strawberries 10 large 100 0.8 37
Almonds 100 20.8 655
Cashewnuts 100 20.2 596
Groundnut 100 26.7 559
Pista 100 19.8 626
Coconut 100 6.8 662
Butter 100 0.0 729
Cheese 100 24.1 348
Curds 100 3.1 60
Buffalo milk 1 cup 200 8 206
Cows milk 1 cup 200 7 160
Goats milk cup 100 3.3 75
Milk powdered 1 table spoon 7 1.9 35
Human milk 100 1.1 65
Ice cream 1 spoon 100 4.1 196
Ghee 1 table spoon 5 0.0 45
Chicken boiled 1 serving 100 17.0 132
Egg boiled 1 medium 48 6.1 77
Egg omlet 1 62 6.6 120
Mutton (Goat) 5-6 pieces 100 21.0 120
Beef boiled 100 25.4 242
Pork 1 serving 100 24.6 317
Fish 1 plate 100 18 81
Limbu juice 1 glass 240 0.0 73
Rice gangi 1 glass 193 8.7 312
Ragi ganji 1glass 280 6.9 263
Butter milk 1 glass 200 2.4 66
Biscuit 2 in number 16 1.6 64
Milk chocolate 1 piece 28 2.4 152
Bengal gram 1 cup 200 7 105
Chana Dal 1 cup 200 7 105
Contd...
Contd...
Black gram, Green 1 cup 200 7 105
gram, Masor dal, Toor
dal, Beans baked,
Peas dried
Cabbage cooked cup 85 1.2 20
Carrot cooked cup 75 0.5 23
Carrot raw 1 large 100 1.2 42
Cauliflower, Brinjal, 125 3.0 36
Bhendi, Bitter guard
Cooked
Cucumber medium 50 0.4 06
Green leafy 125 3.0 32
(palak, menthe)
Potato 100 1.6 97
Radish 99 0.7 17
Sweet potato 100 1.2 120
Beet root 85 1.7 43
Pumpkin 79 1.4 25
Tomato 150 1.5 30
Banana 1 big 100 1.2 99
Mango 1 in no. 100 1.0 54
Apple 1 medium 150 0.3 66
Grapes 22.24 100 1.4 70
Guava 1 medium 100 0.9 51
Orange 1 medium 150 1.4 68
Papaya 1 medium 100 0.6 32
Pineapple 1 slice 84 0.3 44
Whisky 1 peg 30 ml 91
Neera 1 glass 200 ml 0.8 90
Toddy 1 glass 200 ml 0.2 20
Beer 1 glass 240 ml 98
Brandy 1 peg 30 ml 98
Gin 1 peg 30 ml 84
Rum 1 peg 30 ml 98
Red wine 1 glass 100 ml 82
Champagne 1 glass 100 ml 78
Cola/Orange/ 1 bottle 300 ml 84
Lemon drink
Soda 1 bottle 300 ml 00
Samosa 1 2.0 94
Kachori 1 3.0 152
Rasagolla 1 3.0 162
Burfi 1 4.0 74
Bournvita 1 cup 230 ml 10.2 625
Contd...
Nutrition 203
Contd...
Horlicks 2 table spoon 30 4.1 113
Ovaltine 2 table spoon 30 3.8 109
Chapati 2 57 5 193
Poori 2 32 2.2 136
Jowar roti 2 150 7.5 232
Ragi roti 3 185 8.0 460
Ragi balls 1 336 8.0 446
Plain rice 1 plate 170 4.2 200
Wheat bread 1 slice 30 2.3 75
Wheat bread, butter 1 slice 40 2.6 130
and jam1 tea
spoon each
Wheat bun 1 average 35 2.6 120
Wheat parota 1 60 4.8 256
Bajra roti 1 45 3.5 108
Mazia roti 1 45 3.3 102
Idli 1 no 68 2.3 65
Plain dosa 1 no 50 2.0 108
Masala dosa 1 no 101 4.6 212
Uppit/Upma 1 plate 128 3.8 163
Uttappa(onion dosa) 1 no 132 7.3 337
Rava Idli 2 in no 114 5.0 212
Shira(Kesari bath) 1 plate 180 4.0 564
Uddin wada 2 in no 50 5.1 138
Bajji 6 in no 40 2.3 132
Chakli 3 in no 44 8.6 408
Dahi wada 2 in no 99 6.5 177
Tomato omelette 1 in no 56 3.2 100
Poha 1 plate 30 1.8 114
Mysorepak 1 piece 56 2.6 345
Bundi laddu 1 no 34 1.8 150
Rava laddu 1 in no 57 2.9 285
Halva 2 pieces 109 2.6 342
Jalabi 2 in no 41 1.4 313
Cake plain 1 piece 75 3.5 218
Custard cup 130 7.1 164
Preparation Weight Measure Calories Proteins Fats (g) Carbo-
(g) (kcal) (g) hydrates (g)
Chutneys
Coconut 55 2 tbsp 125 2 10 6
chutney
Coriander 20 1 tbsp 45 1 4 2
chutney
Contd...
Contd...
Preparation Weight Measure Calories Proteins Fats (g) Carbo-
(g) (kcal) (g) hydrates (g)
Groundnut 20 1 tbsp 65 3 5 3
chutney
Mint chutney 18 1 tbsp 7 - - 2
Tomato 50 k 32 1 1 5
chutney
Nonvegetarian
Dam ka chicken 125 1k 260 26 15 4
Fish cutlet 80 Two 190 14 9 12
Fish fried 85 Two 220 18 12 6
Fish jhol 110 1k 140 18 3 12
Liver do-pyaza 140 1k 330 22 22 11
Mutton
ball curry 145 1k 240 10 18 10
Prawn curry 145 1k 220 18 7 22
Average Weight of Vegetables (Table 9.17)

Table 9.17: Average weight of vegetables
Vegetable Weight per piece
Ash gourd 1000

Beans 3
Brinjal (small) 20
Brinjal (long) 50
Brinjal (big) 250
Cabbage 500
Capsicum 30
Carrot 40
Cauliflower 200
Drumstick 30
Fenugreek leaves (bundle) 12
Ladies finger 10
Onion (medium) 50
Pumpkin 1100
Radish 150
Raw banana 60
Ridge guard 50
Spinach (bundle) 20
Tomato 40
Nutrition 205
Approximate Weight of Foods Equal to 1 Level Katori (Bowl) of 150 ml

Volume (Table 9.18)
Table 9.18: Approximate weight of foods
Item Weight 1 katori (gm)
Cereals
Rice 150
Rice flour 90
Semolina 120
Wheat flour 90
White flour (maida) 80
Pulses
Bengal gram dhal 130
Bengal gram dhal flout 80
Black gram dhal 130
Green gram dhal 140
Lentil dhal 130
Red gram dhal 140
Whole pulses and legumes
Black-eye beans 130
Green gram whole 140
Kabuli chana 130
Kidney beans 120
Lentil whole 125
Source: Pasricha-count what you eat. National Institute of Nutrition Hyderabad,1989
Average Weight of Nuts and Spices (Table 9.19)
Table 9.19: Average weight of nuts and spices
Nuts Measure/number Weight (gm)

Almonds (small) 15 20
Cashewnut 15 25
Coconut (dry) 1 160
Coconut (fresh) 1 150
Groundnuts 20 6
Poppy seeds 1 tsp 4
Raisins 15 5
Sesame seeds 1 tsp 3
Spices
Asafoetida 1 tsp 6
Black pepper 1 tsp 5
Cardamom 10 1
Chilli powder 1 tsp 7
Cinnamom 1 piece 0.5
Contd...
Contd...
Nuts Measure/number Weight (gm)
Cloves 12 1
Coriander leaves 1 bundle 3
Coriander powder 1 tsp 7
Curry leaves 1 bundle 5
Cumin 1 tsp 5
Fenugreek seeds 1 tsp 6
Garlic 1 pod 0.5
Green chillies 5 5
Mint 1 bundle 5
Mustard seeds 1 tsp 10
Salt 1 tsp 10
Sugar 1 tsp 7
Turmeric 1 tsp 8
Recommended Dietary Allowances for Indians (Table 9.20)
Table 9.20: Recommended dietary allowances for Indians
Group Particulars Body Net Protein Fat Calcium Iron** Vit g/d B- Thiami- Ribofla- Nicotin- Pyrido- Ascorbic Folic Vit B12
wt energy g/d g/d mg/d mg/d retinol caro- mg/d vin ic acid xin acid acid g/d
kg kcal/d tene mg/d mg/d mg/d mg/d mg/d
Men Secondary 2425 1.2 1.4 16
work
Moderate 60 2875 60 20 400 28 600 2400 1.4 1.6 18 2.0 40 100 1
work
Heavy work 3800 1.6 1.9 21
Women Sedentary 1875 0.9 1.1 12
work
Moderate 50 2225 50 20 400 30 600 2400 1.1 1.3 14 2.0 40 100 1
work
Heavy work 2925 1.2 1.5 16
Pregnant 50 +300 +15 30 1000 38 600 2400 +0.2 +0.2 +2 2.5 40 400 1
women
Lactation +0.3 +0.3 +4
0-6 months +550 +25 45 1000 30 950 3800 2.5 80 150 1.5
0-12 months+400 +18 +0.2 +0.2 +0.3
Infants 0-6 months 5.4 108/kg 2.05/kg 500 55 g/ 65 g/ 710 g/ 0.1 25 25 0.2
kg kg kg
6-12 months 8.6 98 kg 1.65 kg 350 1200 50 g/ 60 g/ 650 g/ 0.4
kg kg kg
Children 1-3 years 12.2 1240 22 25 400 12 400 1600 0.6 0.7 8 0.9 30
4-6 years 19.0 1690 30 18 400 2400 0.9 1.0 11 0.9 40
7-9 years 26.9 1950 41 26 600 2400 1.0 1.2 13 1.6 60
Boys 10-12 years 35.4 2190 54 22 600 34 600 2400 1.1 1.3 15 1.6 70
Nutrition
Contd...
207
Contd...
Group Particulars Body Net Protein Fat Calcium Iron** Vit g/d B- Thiami Ribofla- Nicotin- Pyrido- Asorbic Folic Vit B12
wt energy g/d g/d mg/d mg/d retinol caro- mg/d vin ic acid xin acid acid g/d
kg kcal/d tene mg/d mg/d mg/d mg/d mg/d
Girls 10-12 years 31.5 1970 57 19 1.0 1.2 13 1.6 40 70 0.2-1.0
Boys 13-15 years 47.8 2450 70 22 600 41 600 2400 1.2 1.5 16 100
Girls 13-15 years 46.7 2060 65 28 1.0 1.2 14 100 0.2-1.0
Boys 16-18 years 57.1 2640 78 22 500 50 600 2400 1.3 1.6 17 2.0 100
Girls 16-18 years 49.9 2060 63 22 30 1.0 1.2 14 100 0.2-1.0
** On mixed cereal diet with absorption of 3% in man, 5% in woman 8% in pregnant woman.
Approximate Nutritive Value of Some Common Food Preparations (Table 9.21)
Table 9.21: Approximate nutritive value of some common food preparations (per serving and per 100 g)
Food Qty (per Wt. Calories Protein Fat Carbohy- Calcium Phos- Iron Vitamin Thia- Nicotin- Ribo- Vit-
prepara- serving) (per (Kcal) (g) (g) drate (g) (g) phorus (mg) A value min ic acid flavin min
tions serving) (g) (IU) (mg) (mg) (mg) C (mg)
Ragiputtu 1 plate 146 422 4.4 7.4 2.0 0.20 0.20 3.0 280 0.20 0.6 0.06
- 100 289 3.3 5.1 57.7 0.14 0.14 5.5 193 0.14 0.4 0.4
Pulse pre- 1 cup 151 284 9.0 16.4 25.2 0.07 0.13 3.8 366 0.14 2.4 0.10 2.0
parations,
Bengal gram
dal cooked
100 188 6.0 10.9 16.7 0.05 0.9 2.5 242 0.10 1.6 0.7 1.2
Green 1 cup 142 171 7.0 7.7 18.4 0.08 0.9 2.7 33 0.14 2.4 0.11 1.6
gram
dal
cooked
100 120 4.9 5.4 12.9 0.06 0.06 1.9 23 0.10 1.7 0.08 1.1
Red gram cup 96 110 6.4 2.0 16.4 0.05 0.07 2.6 64 0.13 0.7 0.7
dal
cooked
100 115 6.7 2.1 17.1 0.05 0.07 2.7 67 0.14 0.73 0.73
Dal
rasam 1 cup 196 29 1.5 0.9 3.8 0.03 0.03 0.9 72 0.03 0.2 0.2 1.5
100 15 0.8 0.5 1.9 0.02 0.02 0.5 37 0.02 0.1 0.1 0.8
Amaranth 1 cup 140 97 5.1 2.7 13.0 0.50 0.08 8.0 2009 0.07 0.7 0.03 53.0
sambar
Nutrition
100 69 3.6 1.9 9.3 0.36 0.06 5.7 1435 0.05 0.5 0.02 37.9
Radish
209
sambar 1 cup 196 101 4.1 3.6 13.1 0.04 0.07 2.2 73 0.07 0.05 0.03 3.0
Contd...
Contd...
tions serving) (g) (I.U.) (mg) (mg) (mg) C (mg)
100 52 2.1 1.8 6.7 0.02 0.04 1.1 37 0.04 0.26 0.02 1.5
Green gram 1 plate 142 259 13.1 9.2 30.9 0.08 0.20 4.8 120 0.24 1.2 0.10 1.1
Sundal
100 182 9.2 6.5 21.8 0.06 0.14 3.4 85 0.17 0.9 0.07 0.8
Bangal 1 plate 142 272 13.2 11.1 29.7 0.11 0.15 5.5 198 0.16 1.4 0.08 1.1
gram
Sundal
100 192 9.2 7.8 20.1 0.08 0.11 3.9 140 0.11 0.98 0.06 0.8
Cowpea 1 plate 142 255 13.5 8.8 30.3 0.05 0.20 2.5 71 0.30 0.9 0.15 1.1
Sundal
100 180 9.5 6.2 21.4 0.03 0.14 1.8 50 0.21 0.6 0.11 0.8
Vegetable plate 28 47 1.4 2.3 5.1 0.04 0.04 6.6 1942 0.03 0.4 0.03 51.0
prepara-
tions ama-
ranth curry
100 168 5.6 8.2 17.6 0.14 0.14 23.6 6934 0.11 1.4 0.11 182.2
Brinjal curry plate 45 122 1.4 10.7 4.9 0.02 0.05 0.9 9 0.03 0.5 0.06 10.1
100 266 3.1 23.8 10.9 0.04 0.11 2.0 20 0.07 1.1 0.13 22.5
Amaranth plate 42 46 1.2 2.6 4.4 0.05 0.05 6.8 1946 0.02 0.4 0.02 55.0
maseal
100 110 3.0 6.2 10.3 1.2 0.12 16.2 4634 0.05 0.95 0.05 119.1
Cabbage plate 56 81 1.5 5.6 6.1 0.04 0.12 0.9 1028 0.04 0.3 0.03 38.0
and carrot
curry
100 145 2.7 10.0 10.9 0.07 0.21 1.6 1835 0.07 0.05 0.05 67.9
Contd...
Contd...
Preparations 100 52 1.9 1.7 7.2 0.05 0.05 0.10 77 0.02 0.09 0.09 0.7
containing
milk:coffee
1 cup 200 104 3.8 3.4 14.4 0.10 0.10 1.20 154 0.04 0.18 0.18 1.4
Tea 100 36 0.7 0.8 6.5 0.03 0.02 38 0.01 0.05 0.05 0.3
1 cup 200 72 1.4 1.6 13.0 0.06 0.0.4 76 0.02 0.10 0.10 0.6
Cocoa 1 cup 200 174 7.5 7.0 20.2 0.20 0.15 0.30 306 0.08 0.2 0.34 2.7
100 87 3.8 3.5 10.1 0.10 0.08 0.15 153 0.04 0.1 0.17 1.35
Wheat
Payasam 1 cup 154 178 3.4 4.3 31.5 0.09 0.08 0.40 160 0.05 0.1 0.12
100 116 4.2 2.8 20.5 0.06 0.05 0.26 104 0.03 0.06 0.08
Rice 1 cup 154 178 3.2 4.2 31.7 0.09 0.08 0.40 160 0.05 0.1 0.26
Payasam
100 116 2.1 2.7 20.6 0.06 0.05 0.26 104 0.03 0.06 0.17
Bengal 1 cup 140 221 7.7 5.1 35.9 0.07 0.14 4.7 197 0.05 0.2 0.40
gram dal
Payasam
100 158 5.5 3.6 25.5 0.05 0.10 3.4 141 0.04 0.14 0.28
Sago 1 cup 266 227 3.7 4.0 44.0 0.14 0.10 0.17 204 0.06 0.23 2.0
porridge
100 85 1.4 1.5 16.5 0.05 0.04 0.26 77 0.02 0.09 0.8
Rice 1 cup 280 263 7.6 6.2 44.3 0.30 0.20 0.7 306 0.10 0.3 0.34 2.0
porridge
Nutrition
100 94 2.7 2.2 15.2 0.11 0.07 0.25 109 0.04 0.11 0.123 0.8
Contd...
211
Contd...
tions serving) (g) (I.U.) (mg) (mg) (mg) C (mg)
Wheat 1 cup 193 317 8.7 8.0 52.7 0.24 0.22 1.0 408 0.13 0.2 0.28 1.6
porridge+
100 164 4.5 4.1 27.3 0.12 0.11 0.52 211 0.07 0.1 0.13 0.8
Ragi 1 cup 280 263 6.9 6.3 44.7 0.30 0.20 1.7 321 0.20 0.2 0.34 2.0
porridge
100 94 2.5 2.2 16.0 0.11 0.07 1.61 115 0.07 0.07 0.12 0.7
Milk 1 cup 200 130 7.0 7.4 9.8 0.24 0.20 0.8 280 0.06 0.2 0.34 4.0
(cows)
100 65 3.5 3.7 4.9 0.12 0.10 0.4 140 0.03 0.1 0.17 2.0
Milk 1 cup 200 216 8.4 16.0 9.2 0.42 0.30 0.8 368 0.06 0.2 0.42 3.4
(buffalo)
100 108 4.2 8.0 4.6 0.21 0.15 0.4 184 0.03 0.1 0.21 1.7
Butter milk 1 cup 200 36 1.8 2.8 2.0 0.07 0.07 0.2 102 0.03 0.10 0.11 0.9
(curd from
cows milk)
100 18 0.9 1.4 1.4 0.04 0.04 0.1 51 0.02 0.05 0.06 0.45
Butter-milk 1cup 200 66 2.4 5.4 2.8 0.07 0.07 0.2 92 0.02 0.10 0.10 0.9
(curd from
Buffalo milk)
100 33 1.2 2.5 1.4 0.04 0.04 0.1 46 0.06 0.05 0.05 0.45
Egg, Fish 1 cup 39 77 5.8 5.7 0.5 0.03 0.10 1.0 940 0.06 0.1 0.15
and Meat
Prepara-
tions:
Omelette
Omelette 100 187 14.9 14.6 1.3 0.08 0.26 2.6 2410 0.15 0.26 0.38
Contd...
Contd...
Meat curry 1 serving 128 220 11.6 18.0 2.7 0.10 0.07 2.1 227 0.10 0.9 2.20 2.4
100 172 9.1 14.1 2.1 0.08 0.08 1.6 2.16 0.08 0.7 0.16 1.9
Meat fry 1 serving 142 339 21.8 26.0 4.5 0.23 0.20 3.3 294 0.23 7.8 0.30 7.6
100 239 15.4 18.8 3.2 0.16 0.14 2.3 207 0.16 5.5 0.21 5.4
Fish fry 1 serving 100 220 17.5 16.2 1.4 0.05 0.45 1.2 216 0.11 1.3 0.02 1.0

Rice 2 servings 341 686 20.4 39.0 63.6 0.10 0.22 3.5 100 0.20 6.0 0.20 1.1
Mutton
Pulav
100 201 6.0 11.4 18.7 0.03 0.06 1.03 29 0.06 1.8 0.06 0.32
Nutrition
213
BIBLIOGRAPHY
1. Behar M. In: Nutrition in Preventive Medicine, WHO Monograph Ser No 62,
1976.
2. Clinical Dietetics and Nutrition, 4th edn, Second impression, FP Antia and
Philip Abraham, 2001.
3. Food and nutrition facts and figures. Kusum Gupta and others, 5th edn, 2000.
4. Gopalan C, et al. Nutritive Value of Indian Foods, National Institute of
Nutrition, Hyderabad, 1989.
5. ICMR. Recommended Dietary Intakes for Indians, New Delhi, 1990.
6. Narsinga Rao BS. Nutrition, 1986;20(1)14.
7. Nutritive value of Indian foods. Gopalan C and others. NIN (ICMR) Hyderabad,
Revised Edition-1989.
8. Ramachandran LK. Science Reporter, Feb 1978, Council of Scientific and
Industrial Research, New Delhi, 1978.
9. Swaminathan MC. Nutrition Oct. 1970 NIN.
10. Swaminathan M. Handbook of Food and Nutrition, Ganesh & Co, Madras,
1977.
11. Tabers Cyclopedic Medic al Dictionary, 17th edn, 1993; vol. 2:2222.
Chapter
Medical Entomology
10 and Worm Infestations
CHAPTER OUTLINE
ARTHROPODS
PUBLIC HEALTH IMPORTANCE OF WORM INFESTATION
ARTHROPODS
Arthropods comprise the most numerous and varied of the living things
in the environment of man. Some of them are mans allies helping in the
fertilization of flowers, but the majority of arthropods, in general, are
either of no use to man or his most dangerous enemies. They destroy
mans crops and his food reserves; and some which live close to man act
as vectors or carriers of disease. A study of the arthropods of medical
importance is known as medical entomology which is an important
branch of preventive medicine.
Arthropods of Medical Importance

The arthropods of medical importance are given below.
Class: Insecta (Flow chart 10.1)

Flow chart 10.1: Class: Insecta
Distinctive Characters
Distinctive characters of class: Insecta (Fig. 10.1)
Body divisionshead, thorax, abdomen
1. Three pairs of legs
2. One pair of antennae
3. One or two pairs of wings, some are wingless
4. They are found on land
Fig. 10.1: Characteristics of insecta

Medical Entomology and Worm Infestations 217
Class: Archnida (Flow chart 10.2)

Flow chart 10.2: Class: Archnida
Distinctive characters of class: Archnida
1. Body divisionscephalothorax and abdomen (no division) in some cases
2. Four pairs of legs
3. No antennae, no wings
4. Found on land.
Class: Crustacea (Flow chart 10.3)

Flow chart 10.3: Class: Crustacea
Distinctive characters of class: Crustacea
1. Body divisionscephalothorax and abdomen
2. Five pairs of legs
3. Two pairs of antennae
4. Found in water.
Mosquito
General Description
Mosquitoes constitute the most important single family of insects from
the standpoint of human health. They are found all over the world. The
four important groups of mosquitoes in India which are related to disease
transmission are the Anopheles, Culex, Aedes and Mansonia (Fig. 10.2
and Table 10.1).
Mosquito-borne Diseases
Apart from their pestiferous nature, mosquitoes play an important role
in the transmission of human disease. They act as vectors of many diseases
in India (Flow chart 10.4).
Fig. 10.2: Characteristics of mosquitoes

Table 10.1: Differentiation between anopheline and culicine

Tribe genus AnophelineAnopheles CulicineCulex, Aedes
mansonia
Eggs A. Laid singly A. Laid in clusters or rafts, each
B. Eggs are boat-shaped, and raft containing 100-250 eggs
provided with lateral floats ( except-Aedes)
B. Eggs are oval-shaped, and
not provided with lateral floats
Larva A. It has segmented body A. Suspended with head
consisting of head and rest downwards at an angle to
parallel to water surface water surface
B. No siphon tube B. Siphon tube is long and
C. Palmate hairs present on slender
abdominal segments C. No palmate hairs
Pupae A. Siphon tube is broad and A. Siphon tube is long and
short narrow
Adults A. When at rest, inclined at an A. When at rest, the body
angle to surface exhibits a hunch back
B. Wings spotted B. Wings unspotted
C. Palpi long in both sexes C. Palpi short in female,
long and tapering in male
D. In male D. In male
1. Proboscis not adopted for 1. Proboscis bent at an angle
piercing and suckling blood with the body
2. No public health importance 2. No public health importance
E. In female E. In female
1. Proboscis specially 1. Proboscis specially
adopted for piercing skin and adopted for piercing skin and
suckling blood suckling blood
2. Public health importance
vector of malaria
3. Proboscis in straight line with body
F. Breeds in clear water and F. Breeds in dirty water like
slowrunning streams cesspools, stagnant drains
containing organic materials
and polluted water
Flow chart 10.4: Mosquito-borne diseases
Mosquito Control Measures

While there are many methods of mosquito control, experts now
recommend an integrated approach, that is, an approach which avoids
the excessive use of any one method (e.g. insecticides) but tries to combine
one or more methods with a view to obtain maximum results with
minimum inputs and also to prevent environmental pollution with toxic
chemicals and development of insecticide resistance. The various methods
of mosquito control may be classified as below:
Anti-larval Measures
a. Environmental control
b. Chemical control
c. Biological control.
Anti-adult Measures
a. Residual sprays
b. Space sprays
c. Genetic control.
Protection against Mosquito Bites

a. Mosquito net
b. Screening
c. Repellents.
Ticks
Ticks are blood sucking parasites.
They are found in warm climate, and are nocturnal in habits.
Natural hosts for ticks are domestic animals like dogs, cats, and cattle.
They attack man only accidentally.
They can live without food for two to three years.
Families of Medical Importance (Flow chart 10.5)

Flow chart 10.5: Families of medical importance
Public Health Importance of Ticks (Flow chart 10.6)

Flow chart 10.6: Public health importance of ticks
Control Measures (Flow chart 10.7)

Flow chart 10.7: Control measures for ticks
Houseflies
Houseflies are the commonest and most familiar of all insects which live
close to man.
The most important of these are:
Musca domestica
Musca vicinia
Musca nebulo
Musca sorbens.
Life History
Egg: The female lays about 120 to 150 eggs at one sitting. The fly lays from
600 to 900 eggs during lifetime.
Larva: Measures about 12 mm, larval period lasts for two-seven days.
Pupa: Dark brown barrel shaped, measures about quarter of an inch,

Pupal stage lasts for three to six days.
Adult: Complete life cycle from egg to adult lasts for five to six days.
Life span 15 days in summer and 25 days in winter.
Diseases Transmitted
1. Typhoid and paratyphoid
2. Diarrheas and dysenteries
3. Cholera and gastroenteritis
4. Amoebiasis and giardiasis
5. Helminthic infestations
6. Poliomyelitis
7. Anthrax
8. Yaws
9. Trachoma.
Routes of Transmission
1. Mechanical transmission
2. Through vomit drop
3. Defecation.
Control Measures for Houseflies (Flow chart 10.8)
Flow chart 10.8: Control measures
Control measures
Spread of Diseases (Flow chart 10.9)

1. Sandfly
2. Lice
3. Cyclops
4. Rat flea
Flow chart 10.9: Spread of diseases
Control Measures
Sandfly (Flow chart 10.10)

Flow chart 10.10: Control measures for sandfly
Lice (Flow chart 10.11)

Flow chart 10.11: Control measures for lice
Cyclops (Flow chart 10.12)
Flow chart 10.12: Control measures for cyclops

Cyclops
Ratflea (Flow chart 10.13)
Flow chart 10.13: Control measures for ratflea
Itch mite (Flow chart 10.14)

Flow chart 10.14: Control measures for itch mite
PUBLIC HEALTH IMPORTANCE OF WORM INFESTATION
Ascariasis (Table 10.2)

Table 10.2: Ascariasis treatment
Infestation Drug Dose
Ascariasis Mebendazole or 100 mg bd x 3 days
(round worm) pyrentel pamoate 10 mg/kg single dose
Symptoms of Ascariasis
1. Passage of worm in stool or vomitus
2. Vomiting, diarrhea, abdominal distention, flatulence
3. Cough
4. Skin rashes
5. Encephalopathy.
Prevention
1. Personal hygiene
2. Untreated sewage should not be used as fertilizer
3. Proper disposal of sewage.
Enterobius vermicularis (Table 10.3)

Table 10.3: Enterobius vermicularis treatment
Enterobius Pyrentel pamoate or 10 mg/kg single dose
vermicularis Albendazole 100 mg once
(pin worm) (repeated after 4 weeks)
Symptoms
1. Irritability
2. Perianal itching
3. Loss of appetite
4. Symptoms of appendicitis.
Prevention
1. Personal hygiene
2. Nails to be cut and trimmed
3. Washing of nails and perianal area with soap and water.
Trichuris trichiura (Table 10.4)
Table 10.4: Trichuris trichiura treatment

Trichuris trichiura Mebendazole 100 mg bd x 3 days
Albendazole 400 mg/kg once
Symptoms
1. Asymptomatic, if light infection
2. Vague abdominal pain
3. Mild diarrhea
4. Blood in stool
5. Tenesmus
6. Loss of weight
7. Failure to grow if heavy infection

8. Rectal prolapse
9. Volvulus.
Prevention
1. Personal hygiene
2. Untreated sewage should not be used as fertilizer
3. Proper disposal of sewage.
Wuchereria bancrofti (Table 10.5)

Table 10.5: Wuchereria bancrofti treatment
Wuchereria Diethyl carbamazine 6 mg /kg body weight in divided
bancrofti (DEC) doses 12 days
Brugia malayi DEC 3-6 mg/kg 6-12 days
Loa loa DEC 1mg/kg as a single dose
initially double on second day
then 2-3 mg /kg tds daily for 18 days
Onchocerciasis Ivermectin Single dose 200-400 g/kg
annually or biannually
Symptoms
1. Lymphangitis
2. Lymphadenitis
3. Elephantiasis
4. Hydrocole
5. Chyluria.
Prevention
1. Protection against mosquito bite
2. Destruction of mosquitoes
a. Antilarval measures
b. Antiadult measures.
Ancylostoma duodenale (Table 10.6)

Table 10.6: Ancylostoma duodenale treatment
Ancylostoma Mebendazole 100 mg bd 3 days
duodenale, or Pyrentel pamoate 10 mg/kg single dose and
Necator americanus second dose after 2-4 weeks
(Hook worm) needed in North American
Symptoms
1. Abdominal pain
2. Diarrhea
3. Anemia
4. Dyspnea
5. Swelling of feet.
Prevention
1. Avoid walking bare foot
2. Proper disposal of feces
Strongyloides stercoralis (Table 10.7)

Table 10.7: Strongyloides stercoralis treatment
Strongyloides Thiabendazole 25 mg/kg bd 5-7 days
stercoralis
Symptoms
1. Abdominal pain
2. Diarrhea
3. Malabsorption.
Prevention
1. Avoid walking barefoot
2. Proper disposal of feces.
BIBLIOGRAPHY
1. Chatterji KD. Human Parasites and Parasitic Diseases, Calcutta, 1952.
2. Orkin M. JAMA 1971;217:593.
3. Parks Textbook of Preventive and Social Medicine, 17th edn, 2002.
4. Puri IM. The House-Frequenting Flies, their relation to Disease and their
control. Health Bulletin No. 31 Manager of Publications, Govt of India
Press Delhi, 1948.
5. Puri IM. Synoptic Table for the identification of the Anopheline Mosquitoes
in India, Health Bulletin No. 10, Manager of Publications, Govt of India
Press, Delhi,1955.
6. Roy DN, Brown AWA. Entomology, Medical and Veterinary, Excelsior Press,
Calcutta, 1954.
7. Sharma MID. J. Com. Dis, 1974;6, 136.
8. WHO. Control Control of Arthropods of Public Health Importance. WHO
Training Leaflet No. 1 Vector Control Series Geneva, 1966.
9. WHO. Techn. Rep Ser, No.443,1970.
10. WHO. Techn Rep Ser, No.561,1975.
Chapter
11 Disinfection
CHAPTER OUTLINE
DEFINITIONS (DISINFECTANT OR GERMICIDE)
Semmelweis (1818-1865) demonstrated the value of handwashing with

antiseptic solutions.
DEFINITIONS (DISINFECTANT OR GERMICIDE)
Disinfectant
It is a substance which destroys harmful microbes (not usually spores)
with object of preventing transmission of disease. Disinfectants are
suitable for application of only to inanimate objects.
Antiseptic
Antiseptic is a substance which destroys or inhibits the growth of micro-
organisms.
Antiseptic are suitable for application to living tissues. A disinfectant
in low concentrations or dilutions can act as an antiseptic.
Deodorant
It is a substance which suppresses or neutralizes bad odours, e.g. lime
and bleaching powder.
Detergent
It is a surface cleaning agent which acts by lowering surface tension,
e.g. soap which remove bacteria along with dirt.
Sterilization
It is a process of destroying all life including spores. This is widely used
in medical practice.
Disinfection
Refers to the killing of infectious agents outside the body by direct
exposure to chemical or physical agents.
It can refer to the action of antiseptic as well as disinfectants.
Disinfection 229
Types of Disinfection
1. Concurrent disinfection
2. Terminal disinfection
3. Precurrent (Prophylactic) disinfection.
Concurrent Disinfection
The disease agent is destroyed as soon as it is released from the body,
and in this way further spread of the agent is stopped, e.g. urine, feces
vomit, contaminated linen, clothes, hands, dressings, aprons, gloves,
etc. throughout the course of illness.
Terminal Disinfection
Application of disinfective measures after the patient has been removed
by death or to a hospital, or has ceased to be a source of infection,
terminal cleaning is considered adequate, along with airing and sunning
of rooms, furniture and bedding.
Precurrent Disinfection
For example, disinfection of water by chlorination, pasteurization of
milk and handwashing.
Disinfecting Agents
They are classified as:
1. Natural agent
2. Chemical agent
3. Physical agent.
Natural Agents
1. Sunlight
2. Air.
Physical Agents
1. Burning
2. Hot air
3. Boiling
4. Autoclaving
5. Radiation.
Chemical Agents
1. Phenol and related compounds
2. Quaternary ammonia compounds
3. Halogens and their compounds
4. Alcohols
5. Formaldehyde
6. Miscellaneous.
Natural Agents
Sunlight
The ultraviolet rays of sunlight are particularly lethal to bacteria and
some viruses, e.g. bedding, linen and furniture.
Air
Acts by drying or evaporation of moisture which is lethal to most bacteria.
Physical Agents
Burning
Burning should not be done in open air. It is best done in incinerator.
Hot Air
For sterlizing articles such as glassware, syringes, swabs, dressings,

vaseline, oils and sharp instruments.
Hot air sterilization is done at hot air oven maintained at 160 to 180C
at least for one hour to kill spores.
Boiling
Boilers provide temperature above 90C. Boiling for 5 to 10 minutes

will kill the bacteria.
The destruction of spores which require 100C temperature which
can not be achieved in boilers. Boiling is suitable for disinfection of
small instruments which are not used for subcutaneous insertion.
Addition of 1 percent soap and 0.3 percent of washing soda enhances
the effect of boiling, e.g. linens, rubber goods such as gloves.
Autoclaving
Sterilizers, which operate at high temperatures (in excess of 100C) and
pressure are called autoclaves.
Two types: 1 Single chambered 2 double chambered autoclaves.
It attains temp 122C under 15 lbs/sq inch pressure.
Absolute sterility can be obtained only by raising the temperatures of
articles to over 135C, e.g. linen, dressing, gloves, syringes, certain instruments
and culture media.
Radiation
Ionizing radiation is being increasingly used for sterilization of bandages,
dressings, catgut, surgical instruments.
Disinfection 231
Chemical Disinfectants
Articles which can not be sterilized by boiling or autoclaving may be
immersed in chemical disinfectants.
Phenol and Related Compounds
Phenol
Pure phenol or carbolic acid is the best known member of this group.
On exposure to air, the colorless crystals of phenol become pinkish
and on long exposure to air, the color deepens to dark-red.
Pure phenol is not an effective disinfectant.
Crude phenol: It is mixture of phenol and cresol
It is dark oily liquid.
It is effective against gram-positive and gram-negative bacteria.
It is slowly effective against spores and acid-fast bacteria.
It is also effective against certain viruses.
Its effect is weakened by dilution. So it should not be used in less
than 10 percent strength for disinfection of fecal matter.
In 5 percent strength, it may be used for mopping floors and cleaning
drains.
Aqueous solutions of 0.2 to 1 percent are bacteriostatic.
Cresol: It is an excellent coal-tar disinfectant. It is 3 to 10 times as powerful
as phenol.
Cresol is best used in 5 to 10 percent strength for disinfection of feces
and urine
A 5 percent solution is prepared by adding eight ounces of cresol to
one gallon of water (or 50 ml to one liter of water)
Cresol is an all purpose general disinfectant.
Cresol emulsions
Cresol emulsified with soap is known as Saponified cresol. Lysol
contain 50 to 60 percent cresol.
A two percent solution of lysol may be used for disinfection of feces.
Chlorhexidine : It is most useful skin antiseptic
Highly effective against vegetative gram +ve organisms and
moderately active against gram +ve microbes
It is soluble in water and alcohol
It is inactivated by soap and detergents.
Creams and lotions containing one percent chlorhexidine are
recommended for burns and hand disinfection.
Hexachlorphane: Highly active against gram +ve organisms, less active
against gram ve organisms.
Dettol : Nontoxic antiseptic. Can be used safely in high concentrations.

Dettol 5 percent is suitable for disinfection of instruments and plastic
equipment, a contact of at least 15 minutes will be required.
Quaternary Ammonia Compounds
Cetrimide: It is manufactured under trade name cetavlon.

Active against gram +ve organisms
Less effective against gram ve organisms
It is soluble in water
It is used in one o two percent strength.
Savlon: It is a combination of cetavlon and hibitane.
Savlon one in six in spirit is more effective than savlon 1 in 20 aqueous
solution.
For example, clinical thermometer may be best disinfected in savlon
one in six in spirit in just under three minutes.
Halogens and their Compounds

Halogens are actively bactericidal agents, and are the only useful
antiseptics with a sporocidal action.
Bleaching powder
It is chlorinated lime.
It is white amorphous powder with pungent smell of chlorine.
A good sample of bleaching powder contains about 33 percent of
available chlorine.
It kills organisms when used in the strength of one to three percent.
It is widely used for disinfection of water, feces and urine and as a
deodorant.
Drawbacks: It is an unstable compound and loses its chlorine content on
storage. Its action is rapid but brief.
Sodium hypochlorite
A five percent solution is suitable for disinfection of feces and urine
allowing a period of one hour for disinfection.
Freshly prepared hypo-solution containing 100-200 ppm of available
chlorine has been recommended for sterilizing infants feeding bottles.
Halazone tablet: One tablet of halazone containing 4 mg of halazone is
sufficient to disinfect about one liter of water in about half to one hour.
The taste of residual chlorine may be removed by adding sodium
thiosulphate normally in the form of tablets containing about 5.5 mg.
Disinfection 233
Iodine:Iodine in an alcoholic solution of one to two percent is still one of

the most effective skin antiseptics available. Iodine is cheap, readily
available and quick in action.
A drop of tincture of iodine may be added to a one liter of drinking
water for disinfection in an emergency.
Iodophors: These are complexes of iodine and solubilizers.
For example, Povidine-iodine (Betadin)
It is nonirritant and does not stain the skin.
Alcohols: Seventy percent alcohol is lethal in a period of seconds to all
types of non-sporing bacteria. It has no action against spores, but will
inactivate viruses. Below 50 percent concentration activity decreases
rapidly.
Formaldehyde: It is highly toxic and irritant gas which precipitates and
destroys protein. It is effective against vegetative bacteria, fungi, and
many viruses. Slow effective against bacterial spores (e.g. tetanus spores).
It is used as two to three percent solution (20-30 ml of 40% formalin in 1
liter of water) for spraying rooms, walls and furniture.
Formaldehyde gas: Gas is most effective at a high temperature and at a
relative humidity of 80 to 90 percent.
It is used for disinfection of blankets, beds, books and other valuable
articles which cannot be boiled.
Miscellaneous
Lime: About 10 to 20 percent aqueous suspension of lime is known as

milk of lime. Feces and urine can be disinfected by mixing 10 to 20
percent aqueous suspension of lime and allowing the disinfectant to act
for two hours. It is used as a deodorant in public urinals and latrines.
Ethylene oxide: Heat sensitive articles may be sterilized at 55 to 60C by
ethylene oxide which kills bacteria, spores (e.g. tetanus spores) and
viruses.
BIBLIOGRAPHY
1. Bres P. Public Health action in Emergencies caused by Epidemics, WHO,
Geneva, 1986.
2. Parks Textbook of Preventive and Social Medicine, 17th edn, 2002.
3. Report by the Public Health Laboratory Service Committee, Brit Med J 1965;
1:408-13.
4. Todays Drugs Brit. Med J 1964;2:1513-15.
5. WHO. Techn. Rep Ser, 1972; No. 493, p. 58.
Chapter
Insecticides and
12 Rodenticides
CHAPTER OUTLINE
INSECTICIDES AND PESTICIDES
INSECTICIDES AND PESTICIDES

Insecticides are used to kill the insects.
Pesticidesinsecticides, herbicides, rodenticides (Table 12.1),
repellents, fungicides all come under pesticides which are used for control
of pests.
Table 12.1: Characteristics actions and doses of various rodenticides
Rodenticide Characteristics Mode of action Dose
1. Barium White tasteless It is a single dose It is mixed with
Carbonate powder rodenticide but it is wheat or rice flour
a weak rodenticide in the proportion
as compared to of 1 to 4 parts
others. On eating of flour. The mixed
the bait, rats are material is mois-
killed in 2 to 4 hourstened with water
and made into
small round marbles
2. Zinc phosphide 1. It is a grayish It is a single dose 1 part of Zinc
powder rodenticide. Rats phosphide to 10
2. It has a garlic are killed in about 3 parts of wheat or
odour hours rice flour mixed
with a few drops of
edible oil in order
to render it more
attractive to the rats
3. Warfarin White crystalline It is a multiple dose Mixed with wheat
powder, turns (cumulative) poison, or rice flour 1 : 10
brownish yellow which causes internal parts and mois-
on keeping hemorrhage and tened with oil.
slow death in 4 to
10 days
4. Cyanogas White/brownish It gives off hydrogen It is prepared in
Powder amorphous powder cyanide gas when powder form and
moistened, which is is pumped into the
Contd...
Insecticides and Rodenticides 235
Contd...
lethal to both rats rat burrow by a
and their fleas. The special foot pump
gas is very toxic to (cyanogas pump).
other animals and About 2 ounces of
humans also. poison are
pumped into each
burrow after
moistening it and
closing the exit
openings.
Classification
Contact poisonsDDT, HCH, pyrethrum
Stomach poisons
Fumigants.
Class I Organochlorine compounds,
DDT, HCH, chlordane, methoxychlor dieldrin,
Class II Organophosphorous compounds
1. Malathion
2. Fenthion
3. Abate, etc.
Class III Carbamates
1. Propoxur
2. Carbaryl.
DDT (Dichloro-diphenyl-trichloroethane)
DDT synthesized in 1874, by Ziedler.
Insecticidal properties were discovered by Swiss scientistPaul Muller
in 1939.
Properties
It is white amorphous powder
It is insoluble in water
Active ingredient of DDT is para-para-isomer (70-80%)
Soluble in oil and organic solvents.
Action
It is primarily a contact poison.

It acts on nervous system of insects and permeates into the insect
body through cuticle, after dissolving in the waxy coverings of feet
and it paralyses the legs and wings of insect and finally leads to death.
It does not cause immediate death.
Residual action lasts up to 18 months.

It has no repellent action on insects.
Application
It is applied at a dosage of 100 to 200 mg/sq foot area. A five percent of

suspension of DDT is sprayed, at a rate of 1 gallon over an area of 1000
sq feet.
Two percent strength used for mosquito control
Five percent strength used for housefly control and
Ten percent strength used for flea control
It should be applied every six months.
HCH (BHC) Hexachlorocyclohexane

Benzene hexachloride or hexachlorocyclohexane or hexidol or
gammexane
Synthesized earlier than DDT in 1825 by Michael Faraday.
It is white chocolate powder. The active ingredient is 13 to 16 percent
of gamma isomer.
Pure HCH containing 99 percent of gamma isomer is called lindane.
Action
By direct contact with insects.
Application
Every three months. A dose of 25 to 50 mg/sq foot of gamma HCH is

recommended for residual treatment.
Malathion
It is yellow or clear-brown liquid with unpleasant smell.
It is water dispersible.
Dosage
It is 100 to 200 mg/sq foot every three months. It has been used for
killing adult mosquitoes to prevent or interrupt dengue hemorrhagic
fever and mosquito-borne encephalitis epidemic.
Mineral Oil
Kerosene, fuel oil, crude oil, (mosquito larvicidal oil).
Kills larvae and pupae within short time after application
When applied on water, mineral oil spreads and forms thin film, which
cuts off air supply.
Insecticides and Rodenticides 237
Dosage
It is 40 to 90 lit/hectare applied once a week.
The killing power of oil is increased by the addition of 1 percent
DDT.
Paris Green (Copper aceto-arsenite)

It is emerald greenmicrocrystalline powder and it is insoluble in water.
A good sample of paris green contains over 50 percent arsenious oxide.
It is stomach poison.
It kills surface feeder Anopheline larvae.
When applied in granular formulationit kills bottom feeder.
It is applied as two percent dust which is prepared by mixing 2 kg
paris green and 98 kg of diluent such as soapstone powder or slaked
lime in a rotary mixture.
Dosage
1 kg of paris green/hectare of water surface.
BIBLIOGRAPHY
1. Dhir SL. Swasth Hind 1970;14:269.
4. WHO. Manual on Larval Control Operations in Malaria, Geneva, 1973.
Chapter
13 Environmental Models
CHAPTER OUTLINE
CHLOROSCOPE/CHLORINOMETER DRY AND WET BULB THERMOMETER
MAXIMUM AND MINIMUM THERMOMETER (HYGROMETER)
KATA THERMOMETER GLOBE THERMOMETER
SOAK PIT SLOW SAND FILTER
CHLOROSCOPE/CHLORINOMETER
It is used to determine the amount of excess/residual chlorine in water after
chlorination.
It consists of:
1. Orthotolidine reagent
2. Standard test tubes or disks.
3. Empty test tube.
4. Plastic or metal container.
Procedure
1. Take the water to be tested and add it up to the mark in the empty test
tube.
2. Add drops orthotolidine reagent 1:10 parts of water.
3. Shake slowly and match the yellow color formed with the standard
tubes/disks. This gives directly the amount of residual chlorine in the
water if read quickly (within 10 seconds of adding the reagent). After
15 to 20 minutes the color developed is due to free plus combined
chlorine.
4. Orthotolidine arsenite (OTA) test is a modification of the OT test which
avoids the errors due to the presence of other elements like, manganese, iron
and nitrites. It also allows the reading of free and combined chlorine
separately.
DRY AND WET BULB THERMOMETER (HYGROMETER)
This is used for measuring the relative humidity.
It consists of:
1. Ordinary mercury thermometer, which measures the room temperature.
2. Another ordinary mercury thermometer, whose mercury bulb is kept
moist by covering it with a muslin cloth, whose end is dipping in a small
water container.
Environmental Models 239
Procedure
1. The continuous evaporation of water through the muslin cloth, causes
reduction in the temperature in that thermometer (with a cloth) hence
it shows a lower reading than the other thermometer (without a cloth).
2. The drier the air, more rapid will be the evaporation and hence lower
will be the temperature in that thermometer.
3. The difference in the temperatures of the two thermometers varies
inversely with the amount of moisture in the air.
4. The humidity can be read from available charts or slide scale.
5. At 100 percent humidity, both thermometers
will show the same temperature. Since, then
there would be no evaporation.
6. The thermometers should be protected from
radiant heat, direct sunlight and rain.
MAXIMUM AND MINIMUM

THERMOMETER
This is used for measuring the maximum and
minimum temperatures of a place on a given
day (Fig. 13.1).
It consists of:
1. A mercury thermometer with a constriction
at the neck of the mercury bulb.
2. A spirit thermometer with a dumb-bell
shaped rider or index.
Procedure
1. When the temperature rises the mercury in
the mercury thermometer expands.
2. When the temperature falls, the mercury
cannot fall back into the bulb, due to the
constriction, hence the mercury column will
remain at the maximum temperature.
3. After taking the maximum reading, the
mercury thermometer is shaken briskly to
push the mercury back into the bulb (like in
a clinical thermometer).
4. When the temperature falls, the spirit in the
spirit thermometer contracts and drags the
rider down along with it, due to surface Fig. 13.1: Maximum and
tension. minimum thermometer
5. When the temperature rises, the spirit expands and runs past the rider,
hence the rider remains stuck at the minimum temperature.
6. After taking the minimum temperature reading, the rider can be moved
to the surface of the spirit column by gently tapping with fingers.
KATA THERMOMETER (FIG. 13.2A)

Used for Measuring
a. Cooling power of air.
b. Velocity of air.
It consists of:
1. Two alcohol thermometers each with a bulb of 1.8 cm diameter and
4 cm length.
2. The bulb of one is covered with a wet muslin cloth. This is known as
the wet kata thermometer and the other one is known as the dry kata
thermometer.
Procedure
1. The bulbs of both katas are immersed in warm water till the temperature
rises above 130F.
2. The bulb of the dry kata is wiped dry.
3. The muslin cloth over the wet kata is moistened.
4. The katas are suspended in air and the time required for the
temperature to fall from 100F to 95F is noted for both katas. This is
repeated four to five times and the mean of the last three to four readings
is taken.
5. Kata factor is written on the thermometer or the instruction leaflet.
6. Kata factor divided by the mean cooling time gives the cooling power.
7. Dry kata readings of 6 or more, and wet kata readings of 20 or more,
are regarded as an index of thermal comfort.
GLOBE THERMOMETER (FIG. 13.2B)

Used for measuring the Mean radiant heat.
It consists of:
1. A hollow copper globe, 15 cm in diameter, which is coated on its external
surface with soot or black paint.
2. A mercury thermometer, is inserted into the globe through an opening,
so that the mercury bulb lies exactly at the center of the globe.
Procedure
1. The black globe absorbs the radiant heat from the surroundings.
2. The mercury thermometer registers the room temperature plus the
radiant heat.
(A) (B)
Figs 13.2A and B: (A) Kata thermometer; (B) Globe thermometer
3. The difference between the readings of a globe thermometer and an
ordinary thermometer kept side by side is equal to the mean radiant heat.
4. The globe thermometer is also influenced by the air velocity.
Note: A wet globe thermometer is a globe thermometer whose globe is covered
with a wet black cloth. This thermometer exchanges heat with the surroundings
by evaporation, radiation, convection and conduction, like a human being. Hence,
a wet globe thermometer is considered to provide the most comprehensive
measure of the cooling capacity of the environment and is used extensively to
measure the thermal comfort in industries.
Sling Psychrometer (Fig. 13.3)

This is used to measure the relative humidity.
It consists of:
One dry and one wet bulb thermometer mounted side by side on a rotating
wooden frame.
Procedure
1. The cloth over the wet bulb is moistened and the wooden frame is
rotated for about 15 seconds at a rate of 4 revolutions per second so as
to achieve a rotational speed of 5 meters per second. Note the wet bulb
thermometer reading.
2. The psychrometer is again rotated for 10 seconds and the wet bulb
thermometer reading is noted.
3. This is repeated several times, till the wet bulb thermometer tempera-
ture remains constant, with no further fall. Now note the dry bulb
thermometer reading.
4. Relative humidity can be read directly from available charts.
Fig. 13.3: Sling psychrometer
Gully Trap
Three types of pipes are usually seen on
the outer wall of sanitary blocks in a
building. The largest is the storm or rain
water pipe which drains rain water from
the roof into the gully trap. The medium
sized is the soil pipe while the small sized
pipe is the sullage water pipe draining
bathrooms and sinks (Fig. 13.4).
SOAK PIT Fig. 13.4: Gully trap
In the absence of a drainage system in rural areas, sullage water spills and
stagnates along open streets, leading to nuisance an unhygienic conditions,
apart from acting as breeding source for mosquitoes. The soak pit is a
cheap, simple and sanitary method of disposing sullage water. Besides
acting as a sanitary sullage disposal system, the soak pit also acts as a
device for recharging of ground water. Improvements in soak pit have
been suggested by the Safai Vidyalaya, the Central Building Research
Institute, Roorkee, and the Consortium on Rural Technology, Delhi. The
steps in constructing an improved soak pit as suggested by the latter are
given below:
1. Choose a proper site which should be away from a house wall and at
least 10 m distant from any well. The water table should not be very
high. Its water is present three to four meter below ground level, this
technology may not be appropriate.
2. Dig a pit about one meter long, broad and deep. The bottom of the pit
must have a slope of about 15 cm, the direction of the slope being
away from the house.
3. Divide the depth of the pit into roughly four equal parts. Fill the
lowermost part with stones or bricks the size of a coconut. Fill the
second part with stones or bricks the size of a big apple. The third part
is to be filled with stones of the size of an average lemon. The fourth
or uppermost part is for the inlet chamber.
4. The inlet chamber is constructed as follows:
a. At the center, lay the foundation of the chamber in the form of
4 bricks arranged as shown laid with a gap of 5 cm between the
bricks, leaving a central space of 12.5 12.5 cm (5 5).
b. Lay over these bricks a second layer of bricks without leaving any
space between the joints.
c. If necessary, similarly lay a third or fourth layer of bricks. This will
depend upon the slope of the drain from the source outlet of waste
water to the inlet chamber of the soak pit.
5. Take a 1 sq m gunny cloth with a hole in the center about the size of
the inlet chamber. Cover the stone layer of the pit with this gunny cloth.
6. Cover the gunny cloth with a similar sized polythene sheet having a
similar hole in the center.
7. Cover the polythene sheet with soil and fill the pit. Compact the soil
properly. The soak pit is now ready.
8. Make a pucca drain 7 cm (3) wide and 10 cm (4) deep from the
water outlet to the soak pit inlet. It should have a slope of about 8 cm
per meter, i.e. about 1 per foot. The drain should be covered by bricks
or flat stones without joining them. This helps in checking the entry
or solid waste and rain water.
9. Provide a trap near the middle of the drain to check the entry of
suspended solid wastes from entering the pit. Dimensions of the trap
are: length 35 cm (14), breadth 25 cm (10) and height, progressively
sloping along the flow of water, so as to be 25 cm (10) in beginning,
Fig. 13.5: Soak pit
22.5 cm (9) in the middle and 20 cm (8) at end. At the middle

provided a partition with a 7.5 cm 7.5 cm (3 3) hole at the bottom
as shown in Figure 13.5.
10. Cover the trap and the inlet chamber of the pit with a flat stone.
11. Cover the top surface of the soak pit with soil so as to raise it 5 cm
above the surrounding ground level.
SLOW SAND FILTER (FIG. 13.6)

1. Slow sand filter requires to 1 acre area. So the initial cost is much
more (about 20-30 times) than rapid filter, maintenance cost is however
low.
Fig. 13.6: Slow sand filter

2. Total depth of filter is about 3.6 meters and various layers from below
upward are as follows:
Underdrain Two layered bricks
Gravel 15-30 cm
Coarse sand 15-30 cm
Fine sand 0.6 meter
Water on top 1.5 to 1.8 meter
3. Dust free sand insoluble in dilute HCL and having effective size of
0.25 to 0.35 mm is used in slow sand filter.
4. Heart of slow sand filter vital layer, which formed by algae, bacteria,
plankton and diatoms. The development of vital layer is called ripening
of filter, which removes organic matter, holds bacteria and oxidises
organic material.
5. Loss of headwhen vital layer increases in thickness, loss of head
occurs. If this is above 4 feet Scraping the filter is needed.
6. Quality of workit removes 99.9 to 99.99% bacteria.
Rapid Sand Filter (Fig. 13.7)

This is introduced to the world after 80 years after the discovery of slow
sand filter.
1. It occupies very little space.
2. Vital layer is not required. Alum block bring about changes in surface
tension which help to clear out the impurities.
3. Quality of workit removes 98 to 99 percent bacteria.
Washing is easy (back-wash).
Fig. 13.7: A rapid sand filter

Chapter
14 Water Analysis
CHAPTER OUTLINE
DETERMINATION OF TOTAL HARDNESS
BACTERIOLOGY OF WATER
STEPS IN WELL DISINFECTION
DETERMINATION OF TOTAL HARDNESS

Determination of total hardness of water by ethylenediaminetetraacetic
acid (EDTA) method.
Theory
The characteristic of water that prevents the lathering of soap is called
hardness. EDTA is an excellent complexing agent, which forms insoluble
complexes with divalent ions (Ca++ Mg++) present in water. Therefore,
hardness causing salts of calcium and magnesium present in water can
be estimated by titrating the given water sample against standard EDTA
solution using Erichrome Black-T as an indicator. The indicator is effective
in the PH range of about 8 to 11, so while performing the experiment it
is essential to maintain the PH of water sample in between 8 and 11 by
adding a suitable buffer solution.
Procedure
1. Pipette out given 25 ml of hard water into a clean conical flask.
2. Add 2 ml of buffer solution and shake it well.
3. Add 1 to 2 drops of Erichrome BlackT indicator.
4. Titrate the above sample against standard 0.02 M EDTA solution from
the burette until wine red color changes to blue. Let this volume of
EDTA be V2 ml (Table 14.1).
Example
1. In burette Standard 0.2 N EDTA solution.
2. By pipette 25 ml of given water solution.
3. Indicator Erichrome BlackT
4. Color change Wine red to blue.
5. Reactions Wine red to blue.
++
i. Ca + EDTA CaMg EDTA
Stable colorless sample
Water Analysis 247
++
ii. Ca + EBT CaMg EBT
++
Mg
Unstable wine red color complex
iii. CaMg EBT + EDTA CaMg EDTA + EBT
Stable complex
Table 14.1: Burette readings
Burette Pilot I II III Mean
Final reading 6.0 11.7 17.7 23.6
Initial reading 0.0 6.0 11.7 17.7
Difference 6.0 5.7 6.0 5.9 5.9
Calculations
1000 ml of 1 M EDTA = 100 gm of CaCO3
1 ml of 1 M EDTA = 0.1 gm of CaCO3
1 ml of 0.02 M EDTA = 0.01 0.02 gm of CaCO3
5.9 ml of 0.02 M EDTA = 0.1 0.02 5.9 gm of CaCO3
i.e. 25 ml of water sample contains = 0.002 5.9 gm of CaCO3
1000 ml of sample contains = 0.002 5.9 40 gm of CaCO3
Total hardness of water = 0.02 5.9 1000 mg of CaCO3
= 475.2 ppm of CaCO3
BACTERIOLOGY OF WATER
Drinking water has to be visually acceptable, being clear and colorless,
and without disagreeable taste or odor. It should also be safe, being
free from chemical toxins and pathogenic microorganisms. Many more
human diseases, for example, typhoid fever, cholera and other diarrheal
diseases, poliomyelitis and viral hepatitis A and B are waterborne. These
pathogens reach water sources through fecal or sewage pollution. It is
essential to prevent such contamination, treat the water suitably to
remove or destroymicroorganisms, and also to ensure the safety of such
protected water supplies by regular bacteriological surveillance.
Bacteriological Examination of Water

Bacteriological analysis of water supplies should be a regular periodical
procedure and not a random exercise.
Plate Count
This consists of counting the numbers of colonies formed in pourplate
cultures of the water samples, on nutrient agar incubated aerobically, in
parallel, at 37C for 1 to 2 days and at 22C for 3 days. Those that grow
at 37C are those most likely to be associated with organic material of

human or animal origin, whereas those growing at a lower temperature
are mainly saprophytes that normally inhabit water are derived from
soil and vegetables.
The agar count at 22C gives an indication of the amount of
decomposing organic matter in the water available for bacterial nutrition.
Though most bacteria growing at 22C are nonpathogenic to human
beings, on general grounds, the greater the amount of organic matter
present, the more likely is the water to be contaminated with parasitic
and potentially pathogenic organisms. The agar count at 37C is a more
important index of dangerous pollution. A rise in colony count is the
usual signal of some defect in filter beds demanding immediate
attention.
Detection of Coliform Bacteria and E. coli
Presumptive coliform count (Multiple tube technique): The test is called

presumptive because the reaction observed may occasionally be due to
the presence of some other organisms and the presumption that the
reaction is due to coliform organisms has to be confirmed.
An estimate of the number of coliform organisms is usually made by
adding varying quantities of water (0.1-50 ml) to bile salt lactose peptone
water (with an indicator for acidity) and incubating at appropriate
temperatures. Acid and gas formations indicate the growth of coliform
bacilli. Thus, it is possible to state the smallest quantity of water
containing a coliform bacillus and to express the degree of contamination
with this group of organisms.
The following ranges are put up:
One 50 ml quantity of water added to 50 ml double strength medium.
Five 10 ml quantities each to 10 ml double strength medium.
Five 1 ml quantities each to 5 ml single strength medium.
Five 0.1 ml quantities each to 5 ml single strength medium.
MacConkeys fluid medium (modified) is used. The range of quantities
depends on the likely strength of contamination. For highly contaminated
waters, smaller volumes are tested. The bottles are incubated at 37C
and examined after 18 to 24 hours. The presumptive positives are read
off and the remaining negative bottles are reincubated for another 24
hours. Any further positives are added to the previous figures. The
probable number of coliforms per 100 ml are read off from the probability
tables of McCrady. This is known as the presumptive coliform count
or the most probable number of coliforms (MPN).
Water Analysis 249
Differential coliform test: The Eijkmans test is usually employed to find

out whether the coliform bacilli detected in the presumptive test are
E. coli. After the usual presumptive test, subcultures are made from all
the bottles showing acid and gas to fresh tubes of single strength
MacConkeys medium already warmed to 37C. They are incubated at
44C and examined after 24 hours. Incubation at 44C should be carried
out in thermostatically controlled water baths that do not deviate more
than 0.5C from 44C. Those showing gas in Durhams tubes contain
E. coli. From the number of positive tubes obtained, results are read off
the probability tables. Further confirmation of the presence of E. coli can
be obtained by testing for indole production and citrate utilization
(Table 14.2).
Table 14.2: Bacteriological quality of drinking water a
Organisms Guideline value

All water intended for drinking
E. coli or thermotolerant coliform Must not be detectable in any 100 ml
bacteria b,c sample
Treated water entering the distribution system
E. coli or thermotolerant coliform bacteria b
Total coliform bacteria Must not be detectable in any 100 ml
sample
Treated water entering the distribution system Must not be detectable in any 100 ml
sample
E. coli or thermotolerant coliform bacteria b Must not be detectable in any 100 ml
Total coliform bacteria sample
In the case of large supplies where
sufficient samples are examined,
must not be present in 95% of samples
taken throughout any 12-month period.
a. Immediate investigative action must be taken if either E. coli or total coliform bacteria are
detected. The minimum action in the case of total coliform bacteria is repeat sampling: if
these bacteria are detected in the repeat sample, the cause must be determined by immediate
further investigation.
b. Although E. coli is the more precise indicator of fecal pollution, the count of thermotolerant
coliform bacteria is an acceptable alternative necessary, proper confirmatory tests must be
carried out. Total coliform bacteria are not acceptable indicators of the sanitary quality of
rural water supplies, particularly in tropical areas where many bacteria of no sanitary
significance occur in almost all untreated supplies.
c. It is recognized that, in the great majority of rural water supplies in developing countries,
fecal contamination is widespread. Under the conditions, the national surveillance agency
should set medium term targets for progressive improvement of water supplies.
Membrane filtration method: A measured volume of water is filtered through

a millipore filter. All the bacteria present are retained on its surface. It is
placed on suitable media face upwards and incubated at the appropriate
temperature, and the colonies that develop on the surface of the

membrane are counted. After 18 hours of incubation the presumptive
coliform counts and E. coli counts can be directly made.
Detection of Fecal Streptococci

Subcultures are made from all the positive bottles in the presumptive
coliform test into tubes containing 5 ml of glucose azide broth. The
presence of Streptococcus faecalis is indicated by the production of acid in
the medium within 18 hours at 45C. The positive tubes should be plated
onto MacConkeys agar for confirmation.
Millipore membrane technique can also be adopted for this purpose.
Examination for Clostridium perfringens

This is tested by incubating varying quantities of the water in litmus
milk medium (anaerobically) at 37C for five days and looking for stormy
fermentation.
Tests for Pathogenic Bacteria

Under special circumstances, specific pathogens such as typhoid bacilli
or cholera vibrios may have to be looked for in water. This used to be
done by adding the water samples to ten-fold concentrated liquid media,
incubating and subculturing onto appropriate solid media. A simpler
and more sensitive method is to filter the water, sample through
membrane filters and incubate the filters on appropriate solid media.
STEPS IN WELL DISINFECTION

Find the Volume of Water in a Well
a. Measure the depth of water column (h) meters
b. Measure the diameter of well (d) meters
Take the average of several readings of the above measurements
c. Substitute h and d in:
2
3.14 d h 1000
Volume (liters) =
4
d. 1 cubic meter = 1000 liters of water.
Find the Amount of Bleaching Powder

Required for Disinfection
Estimate the chlorine demand of the well water by Harrocks apparatus
(for water testing) which contains six white cups (200 ml capacity). One
black cup with a circular mark on inside, two metal spoons (each holds
2 g of bleaching powder) seven glass stirring rods, one special pipette,
Water Analysis 251
two droppers, starch iodide indicator solution, instruction folder and

calculate the amount of bleaching powder require to disinfect the well.
= 2.5 gm bleaching powder is required to disinfect 1000 liters of water
= 0.7 mg applied chlorine per liter of water.
Procedure
Take one level spoonful (2 g) of bleaching powder in the black cup and
make it into a thin paste with a little water. Add more water to the
paste and make up the volume up to the circular mark with vigorous
stirring. Allow to settle. This is the stock solution.
Fill the 6 white cup with water to be tested up to about a cm below
the brim.
With the special pipette provided add one drop of the stock solution
to the 1st cup, 2 drops to 2nd cup, 3 drops to 3rd cup and so on.
Stir the water in each cup using a separate rod.
Wait for half hour for the action of chlorine.
Add 3 drops of starch iodide indicator to each of the white cups and
stir again. Development of blue color indicates the presence of free
residual chlorine.
Note the first cup which shows distinct blue color, supposing 3rd cup
shows blue color then 3 level spoonfull, 6 gm of bleaching powder
would be required to disinfect 4.55 liters of water.
Dissolve Bleaching Powder in Water

The bleaching powder required for disinfecting the well is placed in a
bucket (< 100 g in one bucket of water) and made into a thin paste. More
water is added till the bucket is nearly full. The content is stirred well
and allowed to sediment for 5 to 10 minute then lime settle down. The
supernatant solution which is chlorine solution, it is transferred to another
bucket and the chalk or lime is discarded (Since lime hardens well water,
it should not be poured into the well).
Delivery of Chlorine Solution into the Well

The bucket containing the chlorine solution is lowered some distance
below the water surface, and the well water is agitated by moving the
bucket violently but vertically and laterally. This should be done several
time and so that the chlorine is mixed intimately to the water inside the
well.
Contact Period
A contact period of one hour is allowed before the water is drawn
for use.
Orthotolidine Arsenite Test

To test for residual chlorine at the end of one hour contact. If the residual
chlorine itself is < 0.5 mg/lit, the chlorination procedure should be repeated
before any water is drawn. Wells are best disinfected at night after the
days drawn off. During epidemics of cholera, wells should be disinfected
every day.
National Water Supply and Sanitation Program (1972): The stipulated
norm of water supply is 40 liters of safe drinking water per capita per
day and at least one hand pump/spot source for every 250 persons.
Provide safe drinking water to all the villages by the turn of century as
available to about 85 percent of the total population and 16 percent
population has access to adequate sanitation.
Chapter
15 Bacteriology of Milk
CHAPTER OUTLINE
BACTERIA IN MILK
BACTERIA IN MILK
Types of Bacteria in Milk

1. Acid forming bacteria
2. Alkali forming bacteria
3. Gas-forming bacteria
4. Proteolytic bacteria
5. Inert bacteria.
Bacteriological Examination
The routine bacteriological examination of milk consists of the following:
Viable Count
This is estimated by doing plate counts with serial dilutions of the milk
sample. Raw milk always contains bacteria, varying in number from about
500 to several million per ml.
Test for Coliform Bacteria

This is tested by inoculating varying dilutions of milk into MacConkeys
fluid medium noting the production of acid and gas after incubation.
Contamination with coliforms comes mainly from dust, dirty utensils and
dairy workers.
Methylene Blue Reduction Test

This is a simple substitute for the viable count. It depends on the reduction
of methylene blue by bacteria in milk when incubated at 37C in complete
darkness. The rate of reduction is related to the degree of bacterial
contamination. Raw milk is considered satisfactory if it fails to reduce the
dye in 30 minutes under standard conditions.
The Resazurin test is similar but the dye resazurin, on reduction, passes
through a series of color changesfrom blue to pink to colorlessthe
shade of color after incubation with milk for a particular period of time,
depending on the degree of contamination. Generally, the 10 minute
resazurin test is done, in which the shade of color is noted after incubation
with the milk for 10 minutes.
Phosphatase Test
This is a check on the pasteurization of milk. The enzyme phosphatase
normally present in milk is inactivated if pasteurization has been carried
out properly. Residual phosphatase activity indicates that pasteurization
has not been adequate.
Turbidity Test
This is a check on the sterilization of milk. If milk has been boiled or
heated to the temperature prescribed for sterilization , all heat coagulable
proteins are precipitated. If ammonium sulphate is then added to the milk,
filtered and boiled for five minutes, no turbidity results. This test can
distinguish between pasteurized and sterilized milk.
Examination for Specific Pathogens
Tubercle bacillus: The milk is centrifuged at 3000 rpm for 30 minutes and
the sediment inoculated into two guineapigs. The animals are observed
for a period of three months for tuberculosis. Tubercle bacilli may also
be isolated in culture. Microscopic examination for tubercle bacilli is
unsatisfactory.
Brucella: Isolation of brucella may be attempted by inoculating cream
heavily on serum dextrose agar or by injecting centrifuged deposit of
the milk sample intramuscularly into guineapigs. The animals are
sacrificed after six weeks and the serum tested for agglutinins and the
spleen inoculated in culture media.
Brucellosis in animals can be detected also by demonstrating the
antibodies in milk, by the milk-ring or the whey agglutination tests.
Chapter
Staining, Culture Media
16 and Microscopy of Slides
of Public Health Importance
CHAPTER OUTLINE
GRAM STAIN ZIEHL-NEELSEN STAIN
ALBERT STAIN CULTURE MEDIA
MICROSCOPIC SLIDES
GRAM STAIN
Aim
To study the morphology and arrangement of bacteria and to classify the
bacteria into gram +ve and gram ve. Gram stain is a differential stain.
Requirement
1. Methylviolet 5 gm
2. Grams iodine 10 gm
Potassium iodide 20 gm
Distill water 1 liter
3. Counterstain 0.5% Safarin
Safarin 5 gm
Distill water 2 liter
Procedure
1. Cover the smear with methylviolet solution and allow to act for one
minute, wash with water.
2. Cover the smear with Grams iodine, keep it for 1 minute.
3. Decolorize with absolute alcohol for 10 to 30 seconds with gentle
agitation till no more stain comes off. Again wash with water.
4. Apply the counter stain (Safarin) for one to two minutes. Wash with
water and dry between blotting paper. Observe under oil immersion
objective.
Result
Gram +ve bacteria take violet color and gram ve bacteria are stained
pink.
ZIEHL-NEELSEN STAIN
Aim
To demonstrate acid fast bacteria
a. Ziehl-Neelsen carbol fuschin
i. Basic fuschin10 gm
ii. Absolute alcohol100 gm
iii. Solution of phenol (5%)1000 ml in water
b. Twenty percent sulfuric acid solution
c. Counter stainLoefflers methylene blue.
Procedure
1. Smear should be prepared from the thick purulent part of the sputum.
2. Smears are dried, heat fixed and stained by Ziehl-Neelsen technique.
The smear is covered with strong carbol fuschin and gently heated to
steaming for five to seven minutes, without letting the stain boil and
become dry.
3. The slide is then washed with water and decolorized with 20 percent
sulphuric acid till the stain become faint pink and then decolorize with
ethanol for two minutes.
4. After washing, the smear is counter-stained with Loefflers methylene
blue or 1 percent picric acid or 0.2 percent malachite green for one
minute. Dry with bloting paper.
5. Under the oil immersion objective, AFB are seen as bright red rods
while the background is blue, yellow or green depending on the
counterstain used.
Result
Acid fast bacilli stain bright red while the tissue cell and other organisms
are stained blue.
ALBERT STAIN
Aim
To demonstrate Corynebacterium diphtheriae, it is a special stain to
demonstrate intracytoplasmic granules.
Requirement
]
Toludine blue 15 gm
Malachite green 20 gm
Glacial acetic acid 100 ml Albert A
Alcohol (95%) ethenol 200 ml
Distilled water 1000 ml
Staining, Culture Media and Microscopy of Slides of PHI 257
]
Alberts iodine (iodine) 60 gm
Potassium iodide 90 gm Albert B
Distilled water 900 ml
Procedure
1. Make smear dry and fix by heat.
2. Cover the slide with Albert A and allow to act for two to three minutes.
3. Cover the slide with Albert B, allow to act for one minute
4. Wash and blot dry.
Result
By this method intracytoplasmic granules stain bluish black, the
protoplasm green and other organisms lightly green.
CULTURE MEDIA
Types of Media
1. Solid media, liquid media.
2. Simple media, complex media, special media.
3. Aerobic media, anaerobic media.
Simple Media
Nutrient broth consists of peptone, meat extract, sodium chloride and
water. Nutrient agar is made by adding two percent agar to nutrient broth.
Complex Media
In complex media ingredients are added for growth of special bacteria.
Synthetic or Defined Media

Prepared from pure chemical substances and exact composition of the
medium is known, e.g. simple peptone water medium, one percent
peptone with 0.5 percent sodium chloride in water.
Enrichment Media (Liquid Media)

In mixed culture wanted bacteria is over grown as compared to unwanted
bacteria, e.g. E. coli overgrow than salmonellae in fecal culture tetrathionate
brothwhich inhibits the coliforms while allowing typhoid and
paratyphoid bacteria to grow freely, e.g. Selinate F broth for dysentery
bacilli.
Selective Media
The inhibiting substance is added to solid media, it enables a greater
number of required bacterium to form colonies than the other bacteria,
e.g. desoxycholate citrate medium for dysentery bacilli.
Indicator Media
This media contain indicator which changes color when a bacterium grows
in them, e.g. incorporation of sulphite in Wilson and Blair medium.
MICROSCOPIC SLIDES
Microorganisms which cause diseases of public health magnitude should
be identified and certain important characteristics related to their
identification, special stains and special media are expected to be known
by the students (Fig. 16.1). The diseases caused by these microorganisms,
their signs and symptoms,their management as well as prevention and
control should also be known to the student. Important aspects related to
the identification, stains and media are mentioned here. For the disease
aspects the student is advised to refer back to the description of these
diseases in the chapter related to case examination.
Fig. 16.1: Microscopy of slides of public health importance

Mycobacterium tuberculosis
Identification
Mycobacteria means fungus like bacteria
1. It is an acid fast bacillus (AFB).
2. They are slender rod shaped that sometimes show branching
filamentous forms resembling fungal mycelium.
3. AFB appear pink against a blue background in the Ziehl-Neelsen stain.
4. They are aerobic, nonmotile, noncapsulated and nonsporing.
5. They are straight or slightly curved rods occurring singly, in pairs or in
small clumps.
6. Solid media for growth includes:
a. Lwenstein-Jensen media
b. Lefflers serum slope
c. Dorsets egg media.
Mycobacterium leprae
Identification
1. They are acid fast bacilli seen singly and in bundles, intracellularly or
lying free outside the cells.
2. They frequently appear as conglomerates the bacilli being bound
together by a lipid like substance, the glia. These masses are known as
globi.
3. The parallel rows of bacilli in the globi present a cigar bundle
appearance.
4. Mycobacterium leprae appear pink against a blue background in the Ziehl-
Neelsen (5% sulfuric acid) stain.
Treponema pallidum
Identification
1. Trepos meaning to turn and nema meaning thread.
2. They are slender spirochaetes with fine spirals and pointed or rounded
ends.
3. They are thin, delicate, spirochaete with tapering ends, and have about
ten regular spirals which are sharp and regular at an interval of about
1 (1 micron).
4. They are motile, exhibiting rotation round the long axis, backward and
forward movements and flexion of the whole body.
5. It stains light rose red with Giemsas stain and can be stained by silver
impregnation.
Neisseria meningitidis
Identification
1. They are Gram-negative, aerobic, nonsporing, nonmotile cocci, which
are both intra- and extracellular.
2. They are spherical cocci arranged in pairs, with the adjacent sides
flattened.
3. Culture media are:
a. Blood agar.
b. Chocolate agar.
c. Meller-Hinton media.
Clinical Features
1. Meningococcemia
a. Sudden onset.
b. Prodromal symptoms like cough, bodyache, headache, myalgia.
c. Fever with chills, tachycardia, tachypnea and shock.
d. Petechial rash.
2. Meningitis
a. Fever, headache and vomiting.
b. Altered sensorium and convulsions.
c. Neck stiffness with other meningeal signs.
Complications
a. Addisons crisis (Waterhouse-Friderichsen syndrome)
b. Deafness and other neurological damage.
c. Disseminated intravascular coagulation (DIC).
Treatment
1. Antibiotics
a. Benzylpenicillin 10 to 20 lacs units intravenously 2 hourly.
b. Chloramphenicol 500 mg intravenously, 6 hourly.
c. Third generation cephalosporins like cefatoxime.
2. Treatment of raised intracranial tension with mannitol.
3. Treatment of shock:
a. IV fluids
b. Steroids
c. Electrolyte imbalance correction.
4. Treatment of Addisons crisis

a. Saline infusion.
b. Hydrocortisone.
Corynebacterium diphtheriae
Identification
1. They are Gram-positive, nonacid fast, nonmotile rods with irregularly
stained segments and metachromatic granules and polar bodies.
2. They are nonsporing, and noncapsulated.
3. They show club-shaped swelling, (coryne meaning club), arranged in
pairs or small groups and form various angles with each other so as to
resemble V or L letter (Chinese letter arrangement).
Lefflers serum slope
McLeods and Hoyles media
Potassium tellurite blood agar.
Neisseria gonorrhoeae
Identifications
1. They are gram-negative, aerobic, nonsporing, nonmotile cocci.
2. They are diplococci with adjacent sides concave, the cocci are reniform
or bean shaped.
3. They are found predominantly within the polymorphs, some cells may
contain as many as hundred cocci. Extracellular forms are also seen.
a. Blood agar.
b. Chocolate agar.
c. Thayer-Martin medium.
Clostridium tetani
Identification
1. They are gram-positive, motile, anaerobic, spore-forming bacilli.
2. Spores are spherical and placed terminally giving a drumstick
appearance.
3. The spores are wider than the bacillary bodies, giving the bacillus a
swollen appearance resembling a spindle (Closter means a spindle)
hence the name Clostridium.
4. Grown in anaerobic conditions only. Special medium used is
Robertsons cooked meat broth.
Clinical Features
1. Inability to open the mouth (Trismus).
2. Inability to swallow.
3. Repeated fall in case of children due to stiffness of muscles.
4. Risus sardonicus (facial muscle contraction giving the appearance of a
smile).
5. Spatula test becomes positive, i.e. on touching the spatula to the soft
palate, patient forcefully closes the mouth.
Complications
1. Laryngeal spasm.
2. Secretions and chest infection.
3. Autonomic nervous system disturbance like cardiac arrhythmia,
hypotension.
Treatment
1. Anti-tetanus serum (ATS) is given intravenously, dose 5000 to 10,000
units.
2. Antibiotic: Benzathine penicillin is given 0.6 to 1.2 megaunit intra-
muscularly.
3. Muscle relaxants:
a. Diazepam
b. Chlorpromazine
c. Barbiturate.
d. Baclofen
4. Ryles tube feeding.
5. Local wound or infection site should be cleaned and antiseptic applied.
Leptospira
Identification
1. They are elongated, motile, flexible bacteria, they are twisted spirally
round the long axis and stained with Giemsa stain.
2. They possess numerous coils, set so close together that they can be
distinguished only under dark ground illumination in the living state
or by electron microscopy.
a. Stuarts medium
b. Fletchers medium.
Clinical Features
1. Leptospirosis
a. Primary phase: Fever, headache and joint pain.
b. Secondary phase:
i. Signs and symptoms of meningeal irritation occurs.
ii. Optic neuritis.
iii. Myelitis.
iv. Peripheral neuropathy.
2. Weils syndrome
a. Fever.
b. Jaundice.
c. Hepatorenal failure.
d. Subconjunctival hemorrhages.
Treatment
1. Benzylpenicillin 20 lacs units Intravenous, 6 hourly.
2. Fluid and electrolyte imbalance to be corrected.
3. Blood transfusion if required.
4. Renal dialysis if required.
Note: Leptospirosis is transmitted by rats and is an occupational hazard of sewage
drainage workers.
BIBLIOGRAPHY
1. Difco Manual of Dehydrated Culture Media and Reagents, 9th edn, Michigan:
Difco Laboratories, 1977.
2. Oxoid Manual, 3rd edn. Baringstoke, R Ananthanarayan, CKJ Paniker, 6th edn.
2000.
Chapter
Hospital Waste
17 Management
CHAPTER OUTLINE
HOSPITAL WASTE DISPOSAL
PLANNING AND ORGANIZATION
INCINERATORS
INTRODUCTION
The following estimates for an average distribution of health care wastes
useful for preliminary planning of waste management. Eighty percent
general health care waste, which may be dealt by the normal domestic
and urban waste management system:
Fifteen percent pathological and infectious waste;
One percent sharps waste;
Three percent chemical and pharmacological waste.
Less than one percent special waste, such as radioactive or cytotoxic
waste, pressurized containers or broken thermometers and used
batteries.
The wastes generated by the hospitals add to the community waste,
thereby putting the load on the already scarce resources. Most of the
hospital-generated waste is potentially infectious and therefore, spreads
infections amongst the community causing a major health problem
(Fig. 17.1).
Fig. 17.1: International infectious substance symbol

Hospital Waste Management 265
Type of Hospital Waste

The waste generated by the hospitals is of two types:
1. High-risk waste (which requires special handling)
2. Non-risk waste (general wastes).
The High-risk Waste

Chemical wastes: Which comprises of materials discarded from diagnostic
and experimental works, cleaning, housekeeping and disinfecting work.
Pathological wastes: Consists of tissues, organic body parts and human
fetuses, which may be infectious.
Highly infectious wastes: Contain pathogens in sufficient quantity, so that
exposure could result in diseases. This category includes cultures and
stocks of infectious agents from laboratory work, wastes from surgery
and autopsies of patients with infectious diseases, waste from infectious
patients in isolation wards, etc.
Sharp: Include needles, syringes, scalpels, blades, broken glasses, nails
and any other material which can cause puncture.
Pressurized containers: Include those containers used for demonstration
or instrumental purposes containing innocuous or inert gas and aerosol
cans which may explode, if incinerated or accidentally punctured.
Laboratory wastes: Include pharmaceutical products, drugs and chemicals
that have been returned from wards, outdated, contaminated or discarded
for any other reason.
General Wastes
General wastes includes domestic wastes, packing material, noninfectious
bleeding from animals, garbage from hospital kitchens and other
waste materials that are not infectious or hazardous to the human health
or environment.
In view of the large number of government hospitals and the rapidly
increasing number of nursing homes and clinics in the private sector, in
the urban as well as in the rural areas, proper training and awareness is
essential for the safe and efficient management of hospital wastes. It is
highly desirable that the wastes disposed should be free from disease
organisms, the disposal system should prevent re-entry of the disease
organisms in the community, there should be no contamination of the
surface soil, water and a check on air pollution (including odors).
Getting rid of the hospital wastes in a proper manner plays a major
role in prevention of emergence and re-emergence of infectious diseases
and also other nosocomial infections and iatrogenic infections.
Hazards and Risks from Hospital Waste Exposure
Indiscriminate Disposal of Infectious

Hospital Waste is Hazardous in Many Ways
1. Occupational hazard to persons who are constantly exposed to these
wastes, like patients and hospital workers and contact personnel such
as milkmen, laundry staff, cleaners, etc.
2. Inappropriately handled waste can be a public health nuisance as it
can spread fatal diseases like Hepatitis B and C and HIV through
injuries caused by contaminated needles or sharps picked by rag
pickers, children, etc. The people who visit hospital to see patients
also are at risk.
3. Impact of badly disposed infectious hospital waste like blood soaked
bandages, used needles and gloves, syringes and linen is great. When
these wastes are indiscriminately thrown in backyards of hospitals or
into open municipal pits, they become breeding sources for disease
producing mosquitoes, flies, rodents and microbes. Besides being an
environmental pollutant, this poses additional health risk to health
workers and rag pickers. The ugly sight and stench of these biomedical
wastes can be highly discouraging for the users of hospital services.
Epidemics can result from the contamination of drinking water and
food sources with these infectious wastes, which can be washed by
rains. Indiscriminate open burning of infectious waste, especially plastics
will result in emission of noxious gases which may produce cancer.
HOSPITAL WASTE DISPOSAL

Disposal strategies form a critical part of total waste management in
hospitals, as any failure in this aspect will have hazardous consequences.
The basic principle is that wastes are disposed in most hygienic and
cost-effective manner, by methods which at all stages, minimize risk to
health environment. Any strategy adopted should have a scientific bases.
The Government of India has prescribed strict procedures and guidelines
for each step in waste management leading to waste disposal in hospitals
(Fig. 17.2).
Fig. 17.2: Hospital waste management structure
Categories of Biomedical Waste (Table 17.1)
Table 17.1: Categories of biomedical waste

Category Waste category
I Human anatomical waste
(Human tissues, organs, body parts)
II Animal waste
(Animal tissues, organs, body parts carcasses,
bleeding parts, fluid, blood and experimental animals
used in research, waste generated by veterinary
hospitals colleges, discharge from hospitals, animal
houses)
III Microbiology and biotechnology waste Local auto-
(Wastes from laboratory cultures, stocks or specimens claving/micro-
of microorganisms live or attenuated vaccines, waving/
human and animal cell culture used in research and incineration
infectious agents from research and industrial
laboratories, wastes from production of biological,
toxins, dishes and devices used for transfer of cultures)
Contd...
Contd...
IV Waste sharps
(Needles, syringes, scalpels, blades, glass, etc. that
may cause puncture and cuts. This includes both used
and unused sharps)
V Discarded medicines and cytotoxic drugs
(Wastes comprising of outdated, contaminated and
discarded medicines)
VI Solid waste Incineration @
(Items contaminated with blood, and body fluids autoclaving/
including cotton, dressings, solid plaster casts, lines, microwaving
bedding, other material contaminated with blood)
VII Solid waste
(Waste generated from disposal items other than the
waste sharps such as tubings, catheters intravenous
sets, etc.
VIII Liquid waste
(Waste generated from laboratory and washing,
cleaning, house keeping and disinfecting activities)
IX Incineration ash
(Ash from incineration of any biomedical waste)
X Chemical waste
(Chemical used in production of biological, chemicals
used in disinfection, as insecticides, etc.)
Objectives of Plan
The objectives of this plan are:
Immediate Objectives
a. To ensure safe, efficient, cost-effective disposal of hospital waste by
developing a waste disposal plan.
b. To train hospital workers on waste management.
Long-term Objectives
a. To develop strategies for reduction of waste generation in the hospital.
b. To create awareness among workers about healthy hospital
surroundings.
c. To create community awareness on environment issues in hospital
surrounding.
PLANNING AND ORGANIZATION

The medical officer incharge of the hospital prepares a strategy on the
following aspects.
Organization
Medical officer incharge will be the overall supervisor of the waste
management program, and composes his team as follows:
Team leader
Waste management co-ordinator (Medical officer incharge of the
hospital)
Members
The second medical officer
Senior staff nurse
FDA
SDA
Senior Group D worker.
Responsibilities
The team will be responsible for:
1. Implementing effective waste disposal procedurescollection,
transport, storage and final disposal and continuously monitoring
them.
2. Designating Group D workers for daily collection of waste, transport
and disposal and monitoring their works.
3. Ensuring that adequate and correct waste containers are kept and
maintained in all strategic areas of the hospital and used appropriately.
4. Supply and monitor use of protectiveclothing, gloves, footwear,
etc. by workers.
5. Arranging training of all staff on waste management through
workshops, demonstrations and talks.
6. Creating environmental awareness among hospital patients, visitors
and community leaders.
7. Developing waste reduction, reuse and recycling strategies.
8. Arranging periodic health check-up of involved personnel and
immunization for all workers.
The team leader will delegate responsibilities to subgroups within
the team to supervise and coordinate all activities.
Staff Appraisal on Hospital Waste Management

The well motivated and committed Medical Officer incharge of the
hospital adopts an effective strategy for proper disposal of the waste.
Entire staff of the hospital will be involved in a dialogue which will
make them understand the mission of the hospital, present status with
regard to hospital waste generation and implications of improper disposal
to patients, workers and to community at large.
Waste Disposal Strategy

Different types of wastes are generated in different quantities by
different sections of the hospital. To achieve the immediate objective of
effective and scientific disposal of hospital waste, the following strategy
will be adopted.
Collection of Waste with Source Segregation

Personnel in each department/section will collect wastes generated in
their areas of responsibility into appropriate plastic bags kept inside
hard, plastic containers which are coded with suitable colors which
indicate nature and type of waste that should be put inside them, e.g.
waste receptacle coded yellow and labeled as put infectious wastes
only with a biohazard sign will receive all infectious waste materials,
blue waste receptacle will receive only sharp waste and plastic/rubber
waste and so on. This process of segregating wastes into their respective
types at the point where they are generated is called segregation at
source. This is a very critical step in proper waste management as this
will facilitate correct disposal strategy and prevent mixing and cross
contamination which can create a serious health risk. Hence, it is essential
that all hospital workers are trained well on color coding and collection
techniques. The table below gives details of color coding for different
kinds of hospital wastes.
Plastic bags should be collected preferably on a daily basis to reduce
spread of infection by flies or spillage by dongs. They should be allowed
to fill to a maximum of three quarters of their capacity to prevent the
bag from tearing and also to facilitate the ease of transport by workers.
Storage
Daily hospital waste from different facilities of the hospital awaiting
final disposal are stored in a store-room meant for the purpose. The
store-room should be away from the service areas and should be dry
and well secured to prevent rodent nuisance.
Transportation
The waste segregated and collected in each point of generation will be
transported daily in a trolley to a central store-room. The transport will
be done in an orderly way according to stipulated rules:
1. Only designated hospital workers will transport the waste.
2. Only one waste receptacle at a time be transported on a trolley to the
store-room where the plastic bag containing the waste is left in store
and the plastic container washed with disinfectant brought back and
kept in the designated place.
3. The wastes will be transported at specified time of the day and through
specified routes which the waste management coordinator will decide
and draw.
4. Before removing from the waste receptacle the transported should
ensure that the mouth of the bag is well secured by tying to prevent
pilferage.
5. Waste from white receptacles will be sorted out for recyclable waste
which are bundled and transported to the store-room separately.
Temporary Storage
The wastes collected daily will be stored in a temporary store-room
which is specially designated for the purpose. The store-room should
be away from all patient care areas and offices as well as residences and
well secured and locked. Recyclable materials are all stored separately
away from other infectious categories of wastes.
Final Disposal of Waste

Recyclable waste: Waste in white containers which may be marketed for
recycling, e.g. all kinds of paperstyping, computer prints, drafts, etc.
corrugated card board packing materials, books, news papers,
magazines, empty metal cans, bottles of aerated water are disposed off
periodically by trading for going rates. Hyposolution used for developing
films can also be marketed for its silver content. Mutilated and treated
wastes of category 4 and category 7, viz. used disposable needles and
syringes, blades, broken glassware, intravenous infusion and blood bags,
tubings, catheters collected in blue containers will be transported and
stored until they are disposed to the market for recycling.
Chemical disinfection: Chemical disinfection involves destruction of most
of the pathogenic microorganisms from inanimate body surface or
material by using chemicals. Instruments and equipment in contact with
patients, infected sharps contaminated floor, beds, etc. may be disinfected
by using neutral disinfectants. Liquid waste from laboratories may be
decontaminated chemically. Bleaching powder, glutaraldehyde, alcohols
or quaternary ammonium compounds may be used. Factors like
concentration and stability of chemicals, surface contact time determines
effectiveness of a chemical disinfectant. The main disadvantage of
chemical disinfectants is that there is no disinfectant which attains the
desirable level III disinfection and there is no easy but accurate post-
treatment test to judge whether the wastes have been effectively
decontaminated. Chemically disinfected medical wastes should continue
to be treated hazardous, unless bacterial testing shows completed
disinfection (Managing medical wastes in developing countries, WHO,
1994). Hence, this type of treatment option may be used only to

decontaminate liquid infection waste from laboratories.
Autoclaves: In autoclaving technology wastes are steam-heated in a special
autoclave meant for waste treatment at specified temperature and
pressure for specific period of time. Decontamination occurs when steam
penetrates the waste. The equipment requires supply of high temperature
and pressurized steam from a boiler unit. Equipment should conform to
standards, mentioned in rules. A gravity flow autoclave or a vaccum
autoclave which functions within specified range of internal waste load
temperature (121 C-149 C), pressure (15-51 psi) and residence time
(30 to 60 min ) should be used. Vaccum autoclaves are more efficient as
absence of air ensures uniform and total penetration of waste by steam
and thus total disinfection. The equipment should have computerized
recording devices to monitor operational parameters and should answer
specified validation tests such as spore testing for Bacillus subtilis at
concentration of 104 spores/mm. Treated waste from an autoclave remains
wet and disinfected to level III, with no volume change. The emission is
likely to give emits foul odour and may be infectious. Autoclaves can
decontaminate most categories of waste except biodegradable organic
waste and toxic waste. Autoclaves with superior technology conforming
to regulations of Central Pollution Control Board (CPCB) are efficient
and offer advantages of volume reduction and odourless and nontoxic
emission. But they may cause more occupational hazard and are not
cost-effective, besides, requiring special elaborate infrastructure.
INCINERATORS
The Central Pollution Control Board has recommended two types of
incinerators:
1. Incinerators for individual hospital/nursing homes/medical establishments.
2. Common incinerator to handle waste from a number of hospital/
nursing homes/pathological laboratories, etc.
Site for Incinerator

Incinerators should be installed at appropriate location to avoid nuisance
to patients and neighborhood.
Standards for Incinerators

All incinerators shall meet the following operating and emission
standards:
Operating Standards
Combustion efficiency (CE) shall be at least 99.0 percent
The combustion efficiency is computed as follows:
% CO 2
CE 100
% CO 2 % CO
1. The temperature of the primary chamber shall be 800 + 50C.
2. The secondary chamber gas residence time shall be at least 1 (one)
second at 1050 + 50C, with a minimum % CO2 oxygen in the stack gas.
Emission Standards
Parameters Concentration mg/Nm 3 at
(12% CO2 correction)
1. Particulate matter 150
2. Nitrogen oxides 450
3. HCI 50
4. Minimum stack height shall be 30 meters above ground
5. Volatile organic compounds in ash shall not be more than 0.01%
Incineration or mass burn technology: The technique of incineration involves

conversion of solids into ash and harmless gas by subjecting to high
temperature. Incineration, as a simple technique known as burning, has
been used to dispose off all types of wastes from hospitals. When
unsorted waste is burnt in simple kilns incinerators, the high temperature
(1000 C) in them converts the solid waste into bottom ash
(noncombustible matter) and fly ash which may contain particulate
matters and some environmentally hazardous noxious gases. Adverse
publicity has resulted in innovation of technically superior, state of the
art models equipped with pollution control components such as scrubbers,
gravity settlers, condenses and deodorants that take care of the possible
environmental hazards due to their emissions. Global/local environmental
benefits, consumption of landfull space, disposal of harmful substances
into environment are factors which are addressed favorably by
incinerators. Incineration offers a direct disposal technology with zero
occupational hazard (from cradle to grave) and a volume reduction of 85
to 95 percent.
Incinerable hospital waste categories include organic waste from
surgery, autopsy and delivery, blood and body fluids from dialysis and
transfusion, microbial and pathological waste from laboratories and
general wastes like papers, cardboard, etc. Heavy metals like mercury,
cadmium and chloride based plastics (PVC) cannot be incinerated as at
low temperatures (800C) they produce hazardous particulate matter
and gases like Hydrogen Chloride dioxins and furons. Reports on PVC
usage in India indicate that hospitals use only two percent of the total
PVC products. Heavy metals are not present in most of the materials
used for patient care in hospitals. Proper source segregation and installing
multi-chambered electrical incinerators with pollution control technology
are key points to ensure environmental safe use of this technology.

The environment protection agency (EPA) recommends use of electrical
incinerator with adequate control devices to ensure safe emission
standards. Regular monitoring and recording of flue gas temperature,
periodic checking of emission gases, annual check-up for wear and tear
and importantly ensuring source segregation and recycling of plastics
are EPA guidelines. With these measures taken, incineration represents
the best practical environmental option (Royal Commission on
Environmental Pollution).
As source segregation can identify the actual quantity of incinerable
waste, hospitals can decide on the capacity of the incinerator they would
like to invest in. Incinerators of different capacities to burn waste beginning
with 3 to 40 kg/hr are available at competitive costs. Incineration as a
process involves waste preparation (segregation) waste charging and
combustion, treatment of emission (through controls) and handling of
incinerator ash. The ash may be collected in thick puncture proof bags
and stored for periodic dumping into a community landfull. Factors
which help the hospital management to decide on characteristics of their
incinerator system are:
i. Air distribution to combustion chambers (stored excess air combustion).
ii. Mode of operation (batch/continuous).
iii. Method of removal of ash (batch/continuous).
Microwave: In microwaving technique, the heat generated inside the
equipment during bombardment of electromagnetic waves into the
rotating molecules of the waste, disinfects the waste. The waste should
have some water content to enhance molecular mobility and thus the
heat generated. Shredded waste is more efficiently disinfected than bully
materials, microwaving attains level III disinfection of all categories of
biomedical waste except those of category 1 and 2, viz. human body
parts and blood-soaked tissues and large metal items. Any microwave
equipment installed must comply with efficacy tests stipulated under
the biomedical rules and have performance guarantee. At the maximum
design capacity, microwave unit should show total destruction of Bacillus
subtilis spores at a concentration of 104 spores per min. Main advantage
of this treatment technology are high efficiency, 30 to 40 percent volume
reduction. Minimal environmental pollution and occupational risk,
compact nature of equipment and cost-effectiveness. Simple and
computerized operation enable semiskilled hospital staff to operate the
equipment. Microwave system has made good advance years. Available
data on microwave system suggest that it satisfies more selection criteria
for choosing suitable technology for waste disposal than any other
acceptable option.
Landfill: Sites are specially constructed areas used as one of the options
for disposal of nonbiodegradable infectious hospital wastes. Hospitals
with large surrounding land may choose this mode of disposal as it is
comparatively simple and cost-effective. The area chosen should be away
from service areas and residential localities. A hospital with bed strength
of 100 may require a landfill site of about 500 to 600 cft. Basic features of
an engineered landfill are:
i. An impermeable clay and pebble base liner to present uncontrolled
release of leachate, a toxic liquid that is released by decomposition
of waste.
ii. Graded base create leachate collection.
iii. Stored earth for covering at the end of each disposal operation.
Essential features of a correct landfill operation are:
i. That all the waste bags are completely pushed into landfill without
getting opened up.
ii. Enough earth and hay cover is put to cover the entire waste so that
stray animals do not pick the waste.
iii. Frequent spray of insecticides is done
iv. Personnel use proper protection like boots, gloves, aprons.
Deep burial: Wastes belonging to category 1, 3 and 6 collected in yellow
containers are disposed by deep burial. The waste coordinator identifies
a suitable place for digging a deep pit or trench within the premises of
the hospital but at a fair distance from the hospital and houses. The
place should not be prone for flooding or erosion and should be away
from shallow wells. The pit may be a 4 feet square with a depth of 6 feet
covered with wire mesh to deny access to animals and prevent accidents.
Each time the waste (human tissuesplacenta, amputated parts, blood
soaked tissues, etc.) is disposed into the pit, should be covered completely
with a thick layer of soil to ensure biodegradation.
Land fill: General wastes from white containers and waste from black
containers will be disposed into an engineered landfill (8 ft 8 ft 4 ft
depth) constructed at a distant corner of the hospital within its premises.
In order to prevent contamination with subsoil water, the base of the
landfill should be made impermeable by putting a stone masonry.
Scattering by stray animals and rag-pickers should be prevented by
covering with a metallic mesh of the size of the landfill which is fixed at
one margin and can be locked at the other margin. The medical officer
in-charge will liase with the engineer in-charge of the hospital to construct
this landfill.
Disposal of biodegradable kitchen waste: The non-infectious, but biodegradable
waste from kitchen, dining areas and wards such as food waste, vegetable
and fruit peals, etc. will be disposed into a vermicompost, which will be
constructed adjacent to the land filling site.
Inertization
The process of inertization involves mixing waste with cement and
other substances before disposal, in order to minimize the risk of toxic
substances contained in the wastes migrating into the surface waste or
ground water. A typical proportion of the mixture is: 65 percent
pharmaceutical waste, 15 percent lime, 15 percent cement and 5 percent
water. A homogeneous mass is formed and cubes or pellets are produced
on site and then transported to suitable storage sites.
Legislative Framework
The Government of India has, under Environment Protection Act (1986),
passed the Biomedical Waste (Management and Handling) Rules in July
1998. The rules define the Administrative Medical Officers of health
care facilities as biomedical waste generators and fix responsibility on
them for developing an effective waste disposal mechanism for the waste
their facilities generate. While the rules spell out treatment and disposal
options for the various categories of biomedical wastes that are generated
in healthcare facilities, they leave the option of handling the general or
domestic type of waste to the generator. Standards for various treatment
and disposal technologies that may be employed have been stipulated.
The rules have also fixed time scale for implementing a treatment and
disposal technology (incinerator technology) in hospitals of different
bed strengths. At state level the State Pollution Control Board is the
regulatory body, which monitors the proper implementation of the rules.
Standards have been fixed for different technology options giving
consideration to international standards accepted by environment
protection agencies in developed countries.
Summary of Biomedical Waste Rules

This notification was issued on 20th July 1998 by the Ministry of Environ-
ment and Forests under Section 6, 8 and 25 of Environment (Protection)
Act, 1986.
1. The rules apply to all persons who generate, collect, receive, store, transport,
treat, dispose and handle biomedical waste in any form.
2. Biomedical waste is any waste generated during diagnosis, treatment,
immunization and research activities involving human beings and
animals.
3. Authorized person is an occupier or operator of any health care
facility who has control over the facility and has been authorized by
the prescribed authority to deal with all aspects of biomedical waste
in accordance with rules.
4. Biomedical waste treatment facility is one where treatment and disposal
of biomedical wastes is carried out.
5. Every generator/occupier of a health care facility has the duty to

take steps to ensure that waste generated is handled without any
adverse effect on human health and environment.
6. Biomedical waste shall be segregated from other wastes at the source,
collected in color coded containers and transported for treatment
and disposal within 48 hours of its generation (Table 17.2).
Table 17.2: Color coding and type of container for
disposal of biomedical wastes
Color Type of container Waste category Treatment options
coding as per schedule
Yellow Plastic bag Cat 1, Cat 2, Cat 3 and Incineration/deep
Cat 6 burial
Red Disinfected container/ Cat 3, Cat 6, and Cat 7 Autoclaving/
plastic bag microwaving/chemical
treatment
Blue/ Plastic bag/puncture Cat 4, Cat 7 Autoclaving/
White proof container Microwaving/Chemical
translu- treatment and
cent destruction/shredding
Black Plastic bag Cat 5, Cat 9 and Disposal in secured
Cat 10 (solid) landfill
What You should Know and Do

Plastics
Plastics are a heterogenous family.
Plastic are polymers of hydrocarbons typically derived from petroleum
of natural gas.
Plastic by not being biodegradable remain in the soil for more then
one thousand years, contaminating the soil and the surrounding water
bodies.
Plastics constitute a major chunk of Health Care Waste. More so, with
the increase in use of disposable items like syringes, IV bags, blood
bags, catheters, etc.
There is four times more plastic in Health Care Waste than in Municipal
Waste.
Problems
Collection and reuse or resale of the single-use (disposable) products
without adequate treatment result in possible spread of infections.
Infection to the waste handlers, especially the rag-pickers and
pourakarmikas.
Improper burning or sub-standard incineration of these plastics release
toxic gases likedioxins and furans and also other harmful gases like
sulphur dioxide, oxides of nitrogen, hydrochlorides, etc. The dioxins and
furans are said to be potent carcinogens.
Improper landfilling or dumping them results in leaching and contamina-

tion of soil and surrounding water bodies.
Proposed Method for Disinfection of Commonly Used
Articles, Materials/Surfaces in Order of Preference (Table 17.3)
Table 17.3: Proposed method for disinfection of commonly used
articles, materials/surfaces in order of preferences
Material Methods
Ampoules Disinfectant with alcohol/methylated spirit/Iodine (PVI) before cutting.
Skin Handwashing is an effective method for preventing the infection
between health professionals. Some microbial agents are always
present in the skin, which passes from the hands of the health
staff to the patients. Handwashing is a very effective method of
decontamination of hands.
Social handwashing: With soap and water removes microorganisms.
This method should be practiced before handling food, eating and
feeding the patient after visiting the toilet. In this method, mechanical
friction is applied to all the surfaces of the hands using soap and
water for 10 seconds and hands are rinsed under a stream of
water and dried with sterilized paper towel.
Hygienic handwashing: A procedure where an antiseptic detergent
preparation is used for washing or is disinfected with alcohol. It is
performed before any invasive procedure, before and after use of
gloves and after contact with blood products. The agents used
are 4% chlorhexidine gluconate solution, solution containing
0.75% available chlorine.
Surgical handwashing: A procedure to kill the bacterial flora and
to decrease the organisms present to prevent wound contamination.
This is done before surgical procedures and any interventions.
Only soap is used, but scrubbing of hands, fingers and nails is very
important.
Thermometer Keeping in gluteraldehyde/PVI/Hexachlorophenes/Chlorhexidine
+ cetrimide (salvon) for at least 10 minutes before next use.
Articles/Ware: Wash with warm detergent, disinfect with chlorine releasing comp-
Stainless steel/ ound/PVI/Formaldehyde/Phenolic compounds/Chloroxylenols/
Enamel plated/ Hexachlorophenes/Chlorhexidine
Plastics, e.g.
Bedpan/urine
bottles/bowls
Surfaces like: Wash with detergent disinfect with chlorine releasing compound/
Floor/walls/ Carbolic acid/PVI/Hexachlorophenes
trolleys/
furnitures/sink/
wash basin
Contd...
Contd ...
Material Methods
Humidifiers Fill daily humidifiers with sterile distilled water containing 0.1%
and incubators silver nitrate. Clean and disinfect with chlorine releasing
compounds/activated glutaraldehyde/alcohol or carbolic acid.
Crockery/ Wash with warm detergent solution, keep in boiling water for
Cutlery 10 minutes/expose to steam. No chemical should be used.
disinfectant
Laboratory Phenolic compounds (carbolic acid)/Chlorine releasing
Discarding jar compounds/Chloroxylenols and Hexachlorophenes
Syringes and Chemical disinfectant must not be used for needle and syringes.
needles
Instruments Keep in concentrations recommended for grossly contaminated
Cheatle forceps articles of PVI/Chlorhexidine + cetrimides/Chloroxylenols,
gluteradehyde. Change the disinfectant daily.
Sharp All articles and surfaces to be disinfected must first be cleaned
instruments and washed with warm water preferable containing detergent
Skin piercing chemical disinfection only as last resort, if sterilization by heat is
and invasive not possible, activated gluteraldehyde/carbolic acid for at least
instruments 10 hours for sterilization.
(not sterilizable
by heat)
Equipment: Chemical disinfection only at last resort, if sterilization by heat is
Catheters, not possible. Immerse in activated solution of gluteraldehyde/
Cystoscope Carbolic acid for 4 to 10 hours or more. Only vegetative bacteria,
Endoscope, fungi and viruses are killed by immersing in surface disinfectants
Laproscope for 30 minutes.
BIBLIOGRAPHY
1. Achary DB, Singh M. The Book of Hospital Waste Management, 2000.
2. Mannual for control of hospital associated infections, NACO, Ministry of
Health and Family Welfare Government of India.
3. Pruss A, Cirouit E, Rushbrook P. Safe management of wastes from health-
care actives, WHO, 1999.
Chapter
National Rural
18 Health Mission
(2005-2012)
CHAPTER OUTLINE
GOALS STRATEGIES
PLAN OF ACTION INSTITUTIONAL MECHANISMS
TECHNICAL SUPPORT ROLE OF STATE GOVERNMENTS UNDER NRHM
FOCUS ON THE NORTH EASTERN STATES ROLE OF PANCHAYATI RAJ INSTITUTIONS
ROLE OF NGOs IN THE MISSION MAINSTREAMING AYUSH
FUNDING ARRANGEMENTS TIMELINES (FOR MAJOR COMPONENTS)
OUTCOMES MONITORING AND EVALUATION
NATIONAL URBAN HEALTH MISSION
INTRODUCTION
Health is fundamental to national progress in any sphere. In terms of
resources for economic development, nothing can be considered of higher
importance than the health of the people. Recognizing the importance of
health in the process of economic and social development and improving
the quality of life of our citizens, the Government of India has resolved to
launch the National Rural Health Mission (NRHM) to carry our necessary
architectural correction in the basic health care delivery system.
In India, 12th April 2005 was a historic day, when our honorable Prime
Minister, Dr Manmohan Singh launched the National Rural Health
Mission. With a budget outlay of Rs.6500 crores for 2005 to 2006 and a
commitment of the government to raise public health expenditure from
0.9 to 2-3 percent of GDP, the goal of the Mission is to improve the
availability of and access to quality health care by people, especially for
those residing in rural areas, the poor, women and children, with initial
focus on 18 high focus states.
Any successful development program stands on four pillars, i.e. political
will, financial resources, administrative infrastructure and scientific
leadership.
The National Rural Health Mission seeks to provide effective health
care to the rural population, especially the disadvantaged groups
improving access, enabling community ownership and demand for
services, strengthening public health systems for efficient service delivery,
enhancing equity and accountability and promoting decentralization.
The National Rural Health Mission subsumes key national programs,
the Reproductive and Child Health II project (RCH II), the National Disease
National Rural Health Mission (2005-2012) 281
Control Programs (NDCP) and the National Disease Surveillance Project

(NDSP). The National Rural Health Mission will also enable the
mainstreaming of AYUSH, i.e. Ayurvedic, Yoga, Unani, Siddha and
Homeopathy Systems of Health.
The Mission covers the country, with special focus on 18 states where
the challenge of strengthening poor public health systems and there by
improve key health indicators is the greatest. These are Uttar Pradesh,
Uttaranchal, Madhya Pradesh, Chhattisgarh, Bihar, Jharkhand, Orissa,
Rajasthan, Himachal Pradesh, Jammu and Kashmir, Assam, Arunachal
Pradesh, Manipur, Meghalaya, Nagaland, Mizoram, Sikkim and Tripura.
NRHM lists a set of core and supplementary strategies to meet its goals.
GOALS
Reduction in infant mortality rate (IMR) and maternal mortality ratio
(MMR).
Universal access to public health services such as Womens health, child
health, water, sanitation and hygiene, immunization, and Nutrition.
Prevention and control of communicable and noncommunicable
disease, including locally endemic diseases.
Access to integrated comprehensive primary health care.
Population stabilization, gender and demographic balance.
Revitalize local health traditions and mainstream AYUSH.
Promotion of healthy lifestyles.
STRATEGIES
Core Strategies
Train and enhance capacity of Panchayati Raj Institutions (PRIs) to own,
control and manage public health services.
Promote access to improved health care at household level through the
female health activist (ASHA).
Health plan for each village through Village Health Committee of the
Panchayat.
Strengthen sub-center through an united fund to enable local planning
and action and more multi-purpose workers (MPWs).
Strengthening existing PHCs and CHC per lakh population for
improved curative care to a normative standard (Indian public Health
standards defining personnel, equipment and management standards).
Preparation and Implementation of an intersect oral District Health Plan
prepared by the District Health Mission, including drinking water,
sanitation and hygiene and nutrition.
Integrating vertical Health and Family Welfare programs at National,
State, block and District levels.
Technical support to National, State, and District Health Mission, for

Public Health Management.
Strengthening capacities for data collection, assessment and review for
evidence based planning. Monitoring and supervision.
Formulation of transport policies for deployment and career development
of human resources for health.
Developing capacities for preventive health care at all levels for promoting
healthy lifestyles, reduction in consumption of tobacco and alcohol,
etc.
Promoting nonprofit sector particularly in underserved areas.
Supplementary Strategies
Regulation of private sector including the informal rural practioners
to ensure availability of quality services to citizen at reasonable cost.
Promotion of public private partnerships for achieving public health
goals.
Mainstreaming AYUSHrevitalizing local health traditions.
Reorienting medical education to support rural health issues including
regulation of medical care and medical ethics.
Effective and viable risk pooling and social health security to the poor
by ensuring accessible, affordable, accountable and good quality
hospital care.
PLAN OF ACTION
Component (A): Accredited Social Health Activists

Every village/large habitat will have a female Accredited Social Health
Activist (ASHA)chosen by and accountable to the panchayat to act
as the interface between the community and the public health system.
ASHA would act as a bridge between the ANM and the village and be
accountable to the panchayat.
She will be an honorary volunteer, receiving performance-based
compensation for promoting universal immunization, referral and escort
services for RCH, construction of household toilets, and other health
care delivery programs.
She will be trained on a pedagogy of public health developed and
mentored through a Standing Mentoring Group at National level
incorporating best practices and implemented through active
involvement of community health resource organizations.
She will facilitate preparation and implementation of the Village Health
Plan along with Anganwadi worker, ANM, functionaries of other
Departments, and Self-Help Group members, under the leadership of
the Village Health Committee of the Panchayat.
She will be promoted all over the country, with special emphasis on
the 18 high focus States. The government of India will bear the cost of
training. Incentive and medical kits. The remaining components will
be funded under Financial Envelope given to the States under the
program.
She will be given a drug kit containing generic AYUSH and allopathic
formulations for common ailments. The drug kit would be replenished
from time-to-time.
Induction training of ASHA to be of 23 days in all, spread over 12 months.
On the job training would continue throughout the year.
Prototype training material to be developed at national level subject to
state level modifications.
Cascade model of training proposed through Training of Trainers
including contract plus distance learning model.
Training would require partnership with NGOs/ICDS Training Centers
and State Health Institutes.
Component (B): Strengthening Sub-Centers

Each sub-centers will have an united fund for local action @ Rs. 10,000
per annum. This fund will be deposited in a joint bank account of the
ANM and Sarpanch and operated by the ANM, in consultation with
the Village Health Committee.
Supply of essential drugs, both allopathic and AYUSH, to the sub-centers.
In case of additional outlays, multipurpose workers (Male) additional
ANMs wherever needed, sanction of new sub-centers as per 2001
population norm, and upgrading existing sub-centes, including
buildings for sub-centers functioning in rented premise will be
considered.
Component (C): Strengthening Primary Health Centers

Mission aims at strengthening PHC for quality preventive, promotive
curative, supervisory and outreach services.
Adequate and regular supply of essential quality drug and equipment
(including supply of Auto Disabled Syringes for immunization) to
PHCs.
Provision of 24 hours service in 50 percent PHCs by addressing shortage
of doctors, especially in high focus states, through mainstreaming
AYUSH manpower.
Observance of standard treatment guidelines and protocols.
In case of additional outlays, intensification of ongoing communicable
disease control programs, new programs for control of noncommnuicable
disease, upgaradation of 100 percent PHCs for 24 hours referral service,
and provision of 2nd. Doctor at PHC level (1 male, 1 female) would be
undertaken on the basis of felt need.
Component (D): Strengthening CHCs for First Referral Care

A key strategy of the Mission is:
Operationalizing 3222 existing Community Health Center (30-50 beds)
as 24 Hours First Referral Units, including of anesthetist.
Codification of new Indian Public Health Standards, setting norms for
infrastructure, staff, equipment, management, etc. for CHCs.
Promotion of Stakeholder Committees (Rogi Kalyan Samitis) for hospital
management.
Developing standards of services and costs in hospital care.
Developing, display and ensure compliance of Citizens Charter at
CHC/PHC level.
In case of additional outlays, creation of new Community Health Centers
(30-50 beds) to meet the population norm as per Census 2001, and
bearing their recurring costs for Mission period could be considered.
Component (E): District Health Plan
District Health Plan would be an amalgamation of field responses
through Village Health Plans, State and Notional priorities for health,
water supply, sanitation and nutrition.
Health Plan would from the core unit of action proposed in areas like
water supply, sanitation, hygiene and nutrition. Implementing
departments would integrate into District Health Mission for
monitoring.
District becomes core unit of planning, budgeting and implementation.
Centrally Sponsored Schemes could be rationalized/modified
accordingly in consulation with States.
Concept of funneling funds to district for effective integration of
programs.
All vertical Health and Family Welfare Programs at district and state
level merge into one commonDistrict Health Mission (DHM)at the
district level and the State Health Mission at the state level.
Provision of Project Management Unit for all district, through
contractual engagement.
Component (F): Converging Sanitation and Hygiene under NRHM
Total Sanitation Campaign (TSC) is presently implemented in 350
districts, and is proposed to cover all district, and proposed to cover all
district in 10th Plan.
Components of TSC include IEC activities, rural sanitary marts,
individual household toilets, women sanitary complex, and School
Sanitation Program.
Similar to the DHM, the TSC is also implemented through Panchayat
Raj Institutions (PRIs)
The District Health Mission would, therefore, guide activities of

sanitation at district level, and promote joint IEC for public health,
sanitation and hygiene through Village Health and Sanitation
Committee, and promote household toilets and School Sanitation
Program. ASHA would be incentivized for promoting household toilets
by the mission.
Component (G): Strengthening Disease Control Programs
National Disease Control Programs for malaria, TB, kala azar, filaria,
Blindness and Iodine Deficiency and Integrated Disease Surveillance
Program shall be integrated under the Mission, for improved program
delivery.
New Initiative would be launched for control of Noncommunicable
Diseases.
Disease surveillance system at village level would be strengthened.
Supply of generic drugs (both AYUSH and Allopathic) for common
ailments at village, SC, PHC/CHC level.
Provision of a mobile medical unit at District level for improved
outreach services.
Component (H): Public-Private Partnership for Public Health Goals,
including Regulation of Private Sector
Since, almost 755 of health services are being currently provided by the
private sector, there is a need to refine regulation
Regulation to be transparent and accountable
Reform to be regulatory bodies/creation where necessary
District Institutional Mechanism for Mission must have representation
of private sector
Need to develop guidelines for public-private partnership (PPP) in
health sector. Identifying areas of partnership, which are need based,
thematic and geographic.
Public sector to play the lead role in defining the framework and
sustaining the partnership
Management plan for PPP initiatives: At District, State and National
levels.
Component (I): New Health Financing Mechanisms
A Task Group to examine new health financing mechanisms, including
Risk Pooling for Hospital Care as follows:
Progressively the District Health Mission to move towards paying
hospitals of services by way of reimbursement on the principal of
money follows the patient.
Standardization of servicesoutpatient, in-patient, laboratory, surgical
interventions and costs will be done periodically by a committee of
experts in each state.
A National Expert Group to monitor theses standards and give suitable

advices and guidance on protocols and cost comparisons.
All existing CHCs to have wage component paid on monthly basis.
Other recurrent costs may be reimbursed for services rendered from
District Health Fund. Over the Mission period, the CHC may move
towards all costs, including wages reimbursed for services rendered.
A district health accounting system, and an ombudsman to be created
to monitor the District Health Fund Management, and take corrective
action.
Adequate technical managerial and accounting support to be provided
to DHM in managing risk pooling and health security.
Where credible Community Based Health Insurance Schemes (CBHI)
exits/launched, they will be encouraged as part of the Mission.
The central government will provide subsidies to cover a part of the
premiums for the poor, and monitor the schemes.
The IRDA will be approached to promote such CBHIs, which will be
periodically evaluated for effected delivery.
Component (J): Reorienting Health/Medical Education to support

Rural Health Issues
While district and tertiary hospitals are necessarily located in urban
centers, they form an integral part of the referral care chain serving the
needs of the rural people.
Medical and paramedical education facilities need to be created in states,
based on need assessment.
Suggestion for Commission for Excellence in Health Care (Medical
Grants Commission), National Institution for Public Health
Management, etc.
Task Group to improve guidelines/details.
INSTITUTIONAL MECHANISMS
Village Health and Sanitation Samiti (at village level) consisting of
Panchayat Representative/s, ANM/MPW, Anganwadi worker, teacher,
ASHA, community health volunteers.
Rogi Kalyan Samiti (or equivalent) for community management of
public hospital.
District Health Mission, under the leadership of Zila Parishad with
District Health Head as Convener and all relevant departments, NGOs,
private professionals, etc. represented on it.
State Health Mission, chaired by Chief Minister and co-chaired by
Health Minister and with the State Health Secretary as Convener
representation of related departments, NGOs, private professionals, etc.
Integration of Departments of Health and Family Welfare, at National
and State level.
National Mission Steering Group chaired by Union Minister for Health

and Family Welfare with Deputy Chairman, Planning Commission,
Ministers of Panchayat Raj, Rural Development and Human Resource
Development and public health professionals as members, to provide
policy support and guidance to the Mission.
Empowered Program Committee chaired by Secretary HFW, to be the
Executive Body of the Mission
Standing Mentoring Group shall guide and oversee the implementation
of ASHA initiative
Task Groups for Selected Tasks (time-bound).
TECHNICAL SUPPORT
To be effective the Mission needs a strong component of technical support
This would include reorientation into public health management
Reposition existing health resource institutions, like Population
Research Center (PRC), Regional Resource Center (RRC), State Institute
of Health and Family Welfare (SIHFW)
Involve NGOs as resource organizations
Improved Health Information System
Mission would require two distinct support mechanismsProgram
Management Support Center and Health Trust of India.
Program Management Support Center

For strengthening management systembasic program management,
financial systems, infrastructure maintenance, procurement and logistics
systems, Monitoring and Information System (MIS), non-lapsable health
pool, etc.
For developing manpower systemrecruitment (induction of MBAs/
CAs/MCAs), training and curriculum development (revitalization of
existing institutions and partnerships with NGO and private sector
institutions), motivation and performance appraisal, etc.
For improved governancedecentralization and empowerment of
communities, indication of IT based systems like e-banking, social audit
and right to information.
Health Trust of India
Proposed as a knowledge institution, to be the repository of innovation
research and documentation, health information system, planning,
monitoring and evaluation, etc.
For establishing public accountability systemsexternal evaluations,
community based feedback mechanisms, participation of PRIs/NGOs, etc.
For developing a Framework for pro-poor innovations.
For reviewing health legislations.
A base for encouraging experimentation and action research.
For inter- and intra-sector networking with National and International

Organizations.
ROLE OF STATE GOVERNMENTS UNDER NRHM

The Mission covers the entire country. The 18 high focus States are
Uttar Pradesh, Bihar, Rajasthan, Madhya Pradesh, Orissa, Uttaranchal,
Jharkhand, Chhattisgarh, Assam, Sikkim, Arunachal Pradesh, Manipur,
Meghalaya, Tripura, Nagaland, Mizoram, Himachal Pradesh and
Jammu and Kashmir. Government of India would provide funding for key
components in these 18 high focus States. Other state would fund
interventions like ASHA, Program Management Unit (PMU), and
upgradation of SC/PHC/CHC through Integrated Financial Envelope.
NRHM provides broad conceptual framework. States would project
operational modalities in their State Action Plans, to be decided in
consultation with the Mission Steering Group.
NRHM would prioritize funding for addressing inter-state and
intradistrict disparities in terms of health infrastructure disparities in
terms of health infrastructure and indicators.
State would sign Memorandum of Understanding with Government
of India, indicating their commitment to increase contribution to Public
Health Budget (Preferably by 10% each year), increased devolution to
Panchyati Raj Institution as per 73rd Constitution (Amendment) Act,
and performance for release of funds.
FOCUS ON THE NORTH EASTERN STATES

All 8th North-East States, including Assam, Arunachal Pradesh,
Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura, are
among the States selected under the Mission, for special focus.
Empowerment to the Mission would mean greater flexibilities for the
10 percent Committed outaly of the Ministary of Health and Family
Welfare, for North-East State.
States shall be supported for creation/upgradation of Health
infrastructure, increased mobility, contractual engagement, and technical
support under the Mission.
Regional Resource Center is being under supported under NRHM for
the North Eastern States.
Funding would be available to address local health issues in a
comprehensive manner, through state specific schemes and initiatives.
ROLE OF PANCHAYATI RAJ INSTITUTIONS

The Mission envisages the following roles for PRIs:
State to indicate in their Memorandum of Understandings (MoUs) the
Commitment for devolution of funds, functionaries and programs for
health, to PRIs.
The District Health Mission to be led by the Zila Parishad. The DHM
will control, guide and manage all public health institutions in the
district, Sub-centers, PHCs and CHCs.
ASHAs would be selected by and be accountable to the Village
Panchayat.
The Village Health Committee of the Panchayat would prepare the
Village Health Plan, and promote integration.
Each sub-center will have an United Fund for local action @ Rs. 10,000
per annum. This Fund will be deposited in a joint Bank Account of the
ANM, in consultation with the Village Health Committee.
PRI involvement in Rogi Kalyan Samitis for good hospital management.
Provision of training to members of PRIs.
Making available health related databases to all stakeholders, including
Panchayats all levels.
ROLE OF NGOs IN THE MISSION

Included in institutional arrangement at National, State and District
levels, including Standing Mentoring Group for ASHA
Member of Task Groups
Provision of Training, Technical Support for ASHAs/DHM
Health Resource Organizations
Service delivery for identified population groups on selected themes
For monitoring, evaluation and social audit
MAINSTREAMING AYUSH
The Mission seeks to revitalize local health traditions and mainstream
AYUSH infrastructure, including manpower, and drugs, to strengthen
the public health system all level.
AYUSH medications shall be included in the Drug Kit provided at
village levels to ASHA.
The additional supply of generic drugs for common ailments at Sub-
center/PHC/CHC levels under the Mission shall also include AYUSH
formulations.
At the CHC level, two rooms shall be provided for AYUSh practitioner
and pharmacist under the Indian Public Health System (IPHS) model.
Single doctor PHCs shall be upgraded to two doctor PHCs by
mainstreaming AYUSH practitioner at that level.
FUNDING ARRANGEMENTS
The Mission is conceived as an umbrella program subsuming the
existing programs of health and family welfare, including the RCHII,
National Disease Control Programs for Malaria, TB, Kala Azar, Filaria,
Blindness and Iodine Deficiency and Integrated Disease Surveillance
Program.
The Budget Head For NRHM shall be created in 2006-07 at National
and State levels. Initially, the vertical health and family welfare programs
shall retain their Sub-Budget Head under the NRHM.
The outlay of the NRHM for 05 to 06 is in the range of Rs 6700 crores.
The Mission envisages an additionality of 30 percent over existing
Annual Budgetary outlays, every year, to fulfill the mandate of the
National Common Minimum Program to raise the outlays for Public
Health from 0.9 percent of GDP to 2 to 3 percent of GDP.
The outlay for NRHM shall accordingly be determined in the Annual
Budgetary exercise.
The States are expected to raise their contributions to Public Health
Budget by minimum 10 percent p.a. to support the Mission activities.
Funds shall be released to State through SCOVA, largely in the form of
Financial Envelopes, with weightage to 18 high focus States.
TIMELINES (FOR MAJOR COMPONENTS)

Merger of Multiple Societies June 2005. Constitution of District/State
Mission Provision of additional generic drugs at SC/PHC/CHC level
December 2005, Operational Program Management Units 2005 to 2006
Preparation of Village Health Plans 2006, ASHA at village level (with drug
kit) 2005-2008. Upgrading of Rural Hospitals 2005 to 2007, Mobile Medical
Unit at district level 2005 to 2008.
OUTCOMES
National Level
Infant mortality rate reduced to 30/1000 live births
Maternal mortality ratio reduced to 100/100,000
Total fertility reduction rate: 50 percent upto 2.1
Malaria mortality reduction rate: 50 percent upto 2010 and sustaining
elimination until 2012
Kala azar mortality reduction rate: 100 percent by 2010 and sustaining
elimination until 2012
Filaria/Microfilaria reduction rate: 70 percent by 2010, 80 percent by
2012 and elimination by 2015
Dengue mortality reduction rate: 50 percent by 2010 and sustaining at
that level until 2012
Japanese encephalitis mortality reduction rate: 50 percent by 2010 and
sustaining at that level until 2012.
Cataract operation: Increasing to 46 lakhs per year until 2012.
Leprosy prevalence rate: Reduce from 1.8/10,000 in 2005 to less than

1/10,000 thereafter
Tuberculosis DOTS services: Maintain 85 percent cure rate through
entire Mission period.
Upgrading Community Health Centers to Indian Public Health
Standards
Increase utilization of First Referral Units from less than 20 to 75 percent
Engaging 250,000 female Accredited Social Health Activists (ASHAs)
in 10 States.
Community Level
Availability of trained community level worker at village level, with a
drug kit for generic ailments
Health Day at Anganwadi level on fixed day/month for provision of
immunization, ante/postnetal checkups and services related to mother
and child health care, including nutrition.
Availability of generic drugs for common ailments at subcenter and
hospital level
Good hospital care through assured availability of doctors, drugs and
quality services at PHC/CHC level
Improved access to Universal Immunization through induction of Auto
-Disabled Syringes, alternate vaccine delivery and improved mobilization
services under the program
Improved facilities for institutional delivery through provision of
referral, transport, escort and improved hospital care subsidized under
the Janani Suraksha Yojana (JSY) for the Below Poverty Line families.
Availability of assured health care at reduced financial risk through
pilots of Community Health Insurance under the Mission
Provision of household toilets
Improved outreach services through mobile medical unit at district level.
MONITORING AND EVALUATION
Health MIS to be developed upto CHC level, and web-enabled for
citizen scrutiny
Subcenters to report on performance to Panchayats, Hospitals to Taluk,
Panchayat Rogi Kalyan Samitis and District Health Mission to Zila
Parishad
The District Health Mission to monitor compliance to Citizens Charter
at CHC Level
Annual District Reports on Peoples Health (to be prepared by Govt/
NGO collaboration)
State and National Reports on peoples Health to be tabled in assemblies,

parliament
External evaluation/social audit through professional bodies/NGOs.
Mid course reviews and appropriate correction.
Is NRHM a New Program of the Government of India?

The NRHM is basically a strategy for integrating ongoing vertical programs
of Health and Family Welfare, and addressing issues related to the
determinants of Health, like sanitation, nutrition and safe drinking Water.
The National Rural Health Mission seeks to adopt a sector wide approach
and aims at systemic reforms to enable efficiency in health service delivery.
NRHM subsumes key national programs, namely, the Reproductive and
Child Health II project, (RCH II) the National Diseases Control Program
(NDCP) and the Integrated Diseases surveillance Project (IDSP). NRHM
will also enable the mainstreaming of Ayurvedic, Yoga, Unani, Siddha,
and Homeopathy System of Health (AYUSH).
What is the Institutional Setup at National, State and District Levels?

The Mission Steering Group under the Chairmanship of the Union Minister
for Health and Family Welfare will provide policy guidance and
operational oversight at the National level. Ministrial/Secretary level
representative of Planning Commission, Rural Development, Panchayati
Raj, Human Resource Development and Health and Family Welfare.
NATIONAL URBAN HEALTH MISSION

As per Census 2001, 28.6 crores people live in urban area. The urban
population is estimated to increase to 35.7 crores in 2011 and to 43.2 crores
in 2021. Urban growth has led to rapid increase in number of urban poor
population, many of whom live in slums and other squatter settlements.
The above situation is reflected in poor health indicators as per the
reanalysis of the NFHS III data as follows:
Urban poor Urban

Under five mortality 72.7 51.9
Number of the children miss 60% 42%
complete immunization
Piped water supply 18.5% 50%
Institutional deliveries 44% 67.5%
Therefore, there is need of the National Urban Health Mission to address

the health economics of the urban poor by facilitating equitable access to
available health facilities by rationalizing and strengthening of existing
capacity of health care delivery for improving the health status of the
urban poor.
Goal
To improve the health status of the urban poor particularly the slum
dweller and other disadvantaged section.
Core Strategies
1. Improving the efficiency of public health system in the cities by
strengthening, revamping and rationalizing urban primary health
structure
2. Partnership with nongovernment provider for filling up of health
delivery gaps
3. Promotion of access to improved health care at household level
through community based groups; Mahila Arogya Samiti.
4. Strengthening the public health through preventing and promotive
action
5. Increased access to health care through risk pooling and community
health insurance model
6. IT enabled services (ITES) and e-governance and monitoring.
7. Capacity building of stakeholders
8. Prioritizing the most vulnerable among the poor.
9. Ensuring quality health care services.
Components of Urban Health Mission (UHM)

1. Planning and mapping
2. Program management
3. Outreach services
4. Primary urban health center
5. Referrals
6. Capacity building, training and orientation
7. Community risk pooling/insurance
8. Public private partnership
9. Monitoring and evaluation
10. Social program for vulnerable groups
11. Support for city level public health action
12. Additional support for National Health Programs
Targets
National Urban Health Mission is expected to achieve the following target
in urban areas:
1. IMR reduced to 30/1000 live birth by 2012.
2. Maternal mortality reduced to 100/100,000 live birth by 2012.
3. TFR reduced to 2.1 by 2012
4. Malarial mortality reduction rate50 percent by 2010 additional
10 percent by 2012
5. Kala-azar mortality reduction rate100 percent by 2010 and sustaining
elimination thereafter
6. Filarial reduction rate70 percent by 2010, 80 percent by 2012 and
elimination by 2015.
7. Dengue mortality reduction 50 percent by 2010 and sustaining it at
that level till 2012.
8. Japanese encephalitis mortality reduction rate50 percent by 2010
and sustaining at that level till 2012.
9. Chikungunya: Reduction in number of outbreaks and morbidity due
to chikungunya by prevention and control strategy.
10. Leprosy prevalence rate: Reduced from 1.8 per 10,000 in 2005 to less
than 1 per 10,000 thereafter.
11. Tuberculosis DOTS Series: Maintain 85 percent cure rate through the
entire Mission period and also sustain planned case detection rate.
12. Reduce the prevalence of deafness by 25 percent (from existing level)
by 2012.
Urban Health Delivery Model

a. At community level
b. Primary health center level
c. Referral units
At Community Level (Urban Social Health Activist, USHA)

The USHA would preferably be a women resident of the slummarried/
widowed/divorced, preferably in the age group of 25 to 45 years.
She should also be a literate women with formal education upto class
eight which may be relaxed only if no suitable person with this qualification
is available.
Essential Service to be Rendered by the USHA

1. Active promoter of good health practices and enjoying community
support.
2. Facilitate awareness on essential RCH services.
3. Facilitate access to health related services available at the Anganwadi/

Primary Urban Health Center and other services being provided by
state/central government.
4. Formation and promotion of Mahila Arogya Samiti in her community.
5. Arrange/escort/accompany pregnant women and children requiring
treatment to the nearest primary urban health center. Secondary/tertiary
level health care facility.
6. Reinforcement of community action for immunization, prevention of
water born and other communicable diseases like TB, malaria, chikungunya
and Japanese encephalitis.
7. Carrying out preventive and promotive health activites with AWW/
Mahila Arogya Samiti
8. Maintenance of necessary information and records about birth and
death, immunization, antinatal services in her assigned locality.
Performance Based Incentive Package for USHA

Activity Proposed incentive/month
1. Organization of outreach services Rs 200
2. Organization of monthly meeting of MAS Rs 100
3. Attended monthly meeting at UHC Rs 200
4. Organize Health and National Day in collaboration with AWW Rs 100
5. Organize community meeting for strengthening 50 per meeting
preventive and promotive services (200 upper limit)
6. Provide support to baseline survey 5 per house hold
and filling up of family health register (once a year)
7. Maintain records as per the desired 50 per month
norms like household registers.
meeting minutes, outreach camps register.
8. Additional Immunization incentives for 5 per child
achiving complete immunization among the
children in her area of responsibility.
Primary Urban Health Center

Generally one urban health center is for approximately 50,000
population.
In slum area, one UHC for 20,000 to 30,000 population.
In cities, UHC may be established for 75,000 population.
In areas with very high density, isolated slum clusters or disadvantage
group, one UHC can be established for 5000 to 10,000 population.
Services available under UHC: UHC can provide services for 4 hours in
the morning and 2 hours in the evening. For provision of certain services
evening OPD if required.
The services provided in UHC will include OPD, basic lab diagnosis,
drug and contraceptive dispensing, distribution of health education
material and counseling for all communicable and noncommunicable

disease.
Staffing Pattern
1 Docter
1 Labtechnician
1 Pharmacist
2 Staff nurses
4 ANMs
1 Program manager/Community mobilization officer/Peon/ Sweeper.
Financial support: Annual financial support in the form of Rogi Kalyan
Samiti/Hospital Management Committee fund of Rs. 50,000 per UHC per
year.with the amount being proportional to the population covered @ Re
1.00 per head a PUHC covering 40,000 population will get Rs. 40,000.
Referral units: State government hospitals and medical colleges, apart
from private hospitals will be empanelled/accredited to act as referral
points for different types of health care services. The referral services will
be cash-free for the beneficiary and will be financed by community health
insurance or voucher scheme as per the PIP developed for the cities.
Chapter
19 Sanitation of Camps
CHAPTER OUTLINE
CAMP SITE ACCOMMODATION AND EQUIPMENT
FOOD AND COOKING ARRANGEMENTS DISPOSAL OF REFUSE AND EXCRETA
DISPOSAL OF STABLE LITTER
INTRODUCTION
In view of the fact that camps and temporary lodgements have been freely
set up all over the country, a description of the general sanitary control of
camps demands special consideration. For all practical purposes, camps
may be regarded as so many improvised townships where the different
tents or temporary huts represent so many houses. Although the sanitation
of camps is more or less based on the same principles as of ordinary houses
or towns, in practice certain sanitary rules have to be followed because of
their temporary nature and because very often they are located in places
where sanitary conditions are not ideal. The following pointes require
consideration with reference to camps:
1. Camp site.
2. Accommodation and equipment.
3. Water supply
4. Food and cooking arrangements.
5. Disposal of refuse, excretal matter and waste water.
CAMP SITE
The site should be on a high ground not subject to flooding or water logging
and should have good approach from the main road. The soil should be
porous and physical features suitable for easy and rapid surface drainage.
Irrigated or marshy land or land with steep slope should be avoided; gentle
slope however facilitates drainage. While the site should not be close to a
bazaar, its accessibility, facility for transport and easy availability of
supplies should be kept in mind.
The ground and its surroundings must be dry and free from dense vegetation.
A high sub-soil water creates dampness and water-logging. All hollows and
other excavations where water can collect should be filled up to prevent
breeding of mosquitoes. For the same reason, digging or excavating the
soil within the camp area is unwise.
Agricultural land, because of its propensity to breed flies, should be

avoided. Wherever possible, there should be sufficient open land all
around the camp area to sever as a protective boundary.
The most important consideration which should dominate selection of
a camp site is the facility which exists for obtaining water. This is specially
important in temporary camps. When camp sites are likely to be occupied
for a longer period, the feasibility of bringing in filtered water by pipe
from outside or sinking of deep tube wells locally may be considered.
ACCOMMODATION AND EQUIPMENT

The lay out of a camp should be properly planned after a survey of the
site. In laying out a camp, the following particulars should be attended to:
i. The front of the camp should face the prevailing wind.
ii. The sleeping accommodation should be in front, with kitchens and
messing accommodation nearby at one side.
iii. The bathing area and water point should be so at one side, well away
from the conservancy area, and with drainage so arranged as to
prevent the water logging of the camp.
iv. Camp roads should be so arranged that traffic for watering horses
and the delivery of supplies do not cover the cooking and messing
areas with manure-laden dust.
v. Surface drainage of the camp area should be provided.
Water
Supply of safe water is of primary importance and every effort should be
made to see that the water is not only safe but the chances of accidental
contamination are also nil. In camps where arrangements are made for
supply of filtered water or deep tube well water, no inconvenience is
experienced. The water is delivered from overhead reservoir and stand
pipes. But attention should be paid to see that no contamination occurs
due to defective storing or from other sources. The delivery taps should
be near the kitchen.
FOOD AND COOKING ARRANGEMENTS

With regard to cook and cooking arrangement, attention should be paid
to the following:
i. The kitchen should be located at a distance from latrines, urine pits
and the receptacles for garbage and refuse, preferably at the opposite
end but within easy access of the water cart. It should be well-lighted
and ventilated preferably fly proofed and provided with a smoke
outlet.
Sanitation of Camps 299
ii. There should be suitable provision for storage of food.

iii. All sullage water must be made to pass into pits from which it can
drain into suitable dry trenches. In the alternative, it can be kept in
special covered tubs or reservoirs and removed daily for sanitary
disposal.
iv. Provisions should be made for washing cooking utensils, plates, dishes,
etc. It is always convenient to have a special place allocated for this.
v. There should be provision of ample supply of hot water and a
sufficiency of clean dish-cloths to secure a clean and wholesome food
service.
vi. Everything used for food service namely, utensils, tables, knives and
forks, plates and dishes, tables should be clean.
The practice of using earth. For cleansing cooking utensils, should be
forbidden. Utensils should be cleaned by baked sand stored in a clean tin.
Where ash is used, one should see that its preparation, collection and
storing are sanitary.
DISPOSAL OF REFUSE AND EXCRETA

One of the important duties of the officer-in-charge of the camp is to ensure
that disposal of refuse and excreta is carried out in such a way as these
will be rendered innocuous.
These generally consist of:
a. Dry camp and kitchen refuse.
b. Liquid waste.
c. Feces.
Dry Camp and Kitchen Refuse

Dry camp and kitchen refuse generally consist of bits of papers and crockery.
These should be collected daily in sand bags or in specially provided
receptacles by men detailed for the purpose.
Dry kitchen refuse consists of scraps of food, remnants of vegetables,
fruits, etc. All these should be collected in covered metal receptacles and
not allowed to scatter in and around the kitchen.
The solid refuse both from the camp and kitchen, should either be buried
in deep pits at a safe distance or better still burnt in an incinerator. It may
also be disposed of the special type of dustbins in which refuse can be
burnt in the bin itself.
Liquid Waste
This consists of urine (human and animal), kitchen sullage and ablution
water.
i. Kitchen sullage, consisting mainly of greasy water, soon becomes

very foul if not properly disposed of. These should be collected in
mental receptacles placed on a stand fitted with a cover. If allowed
to run direct on to the soil, it makes a greasy quagmire covered with
scum which attracts flies. When its disposal depends on the
absorptive pits filed with hay, straw or coarse brushwood. Here the
grease and other organic solids are entangled allowing the clear liquid
to run away. The hay and straw loaded with greasy and other fatty
matter should be buried or burnt and replaced by fresh material daily.
ii. Urine is disposed of in soakage pits. The pit may be combined with
urinal. This consists of two parts, the urine receiving portion on top
consisting of either a trough, funnel or tin; and the disposal portion
consisting of the soakage pit below the ground consisting of the
soakage pit below the ground.
Disposal of Feces
In permanent camps provided with piped water supply and where water-
carriage system prevails, there is no trouble. But in places where such
arrangement cannot be made, one should have recourse to trench system,
earth-pet or service latrine.
The first principal in any form of trench system is to construct it in such
a way as will not pollute the surrounding ground. Shallow trenches should
be avoided. They should be regarded as an emergency measure and must
not be used for more than two to three days.
Deep trenches cover less ground and are better suited for the purpose.
These should be made fly-proof. Trenches should be source of water supply
or kitchen. There should always be a superstructure for protection against
inclement weather and partitions for privacy.
Where convenient, bored-hole, well or pit latrines may be provided.
Boredhole latrines will be found suitable in places where the sub-soil water
in not very high. Generally, one seat for every 12 persons will be found
convenient.
If service latrines are used, the pans or pails should be daily emptied
and the contents quickly removed for final disposal either by trenching or
incineration, whichever will be available and convenient. After emptying,
the pans should be thoroughly cleansed. Facilities for such cleansing
should be available and convenient. After emptying, the pans should be
thoroughly cleansed. Facilities for such cleansing should be provided with
soakage pits for waster. The cleaned pans should be treated with crude
oil before being replaced under the seats. There should be a small
conservancy staff to look after the cleanliness of the latrines and urinals
and also for removal of refuse. Washing facilities should be provided and
there should be adequate supply of water for washing purposes. The
approach to the latrines should always be kept clean and lighted at night.
Sanitation of Camps 301
DISPOSAL OF STABLE LITTER

Much nuisance is caused by stable litter which is generally horse manure
or cow dung. Daily collection and complete removal of these ensure
freedom from infestation by flies and biting insects to a large extent.
Arrangements should be made for their sanitary removal and disposal
either by incineration or by burying in deep pits.
Chapter
Indian Systems
20 of Medicine
CHAPTER OUTLINE
AYURVEDA SYSTEM OF MEDICINE SIDDHA SYSTEM OF MEDICINE
UNANI SYSTEM OF MEDICINE HOMEOPATHY
YOGA NATUROPATHY
ALLOPATHY
INTRODUCTION
Indian systems of medicine covers both the systems of which originated
in India and outside but got adopted in India in the course of time.
These systems are Ayurveda, Siddha, Unani, Homeopathy, Yoga and
Naturopathy. These systems have become a part of the culture and
tradition of our country.
AYURVEDA SYSTEM OF MEDICINE

Ayurveda means the "science of life". Ayurveda or the Indian Science of
Life oriented and developed around 1000 BC the knowledge of Ayurveda
was documented by Charaka and Sushruta.
According to Ayurveda, health is considered a pre-requisite for achieving
the goals of life. Ayurveda takes an integrated view of the physical and
spiritual aspects of man.
The philosophy of Ayurveda is based on the theory of Panchmahabhutas
of which all the objects and living bodies are composed of these five
elements. The combination of these five elements are represented in the
form of tridosha. For example, vata (Ether+Air), pitta (Fire) and kapha
physiological entities in living beings. The mental-spiritual attributes
are described as satva, rajas and tamas. The various permutations and
combinations of satva, rajas and tamas constitute human temperament
and personality. Ayurveda considers the human being as a combination
of tridoshas, (Panchmahabhutas) (5 elements), seven body tissue (Saptadhatu),
five senses (Panch-indriyas), mind (Manas), intellect (Budhi) and soul
(Atman).The doctrine of Ayurveda aims to keep these structural and
functional entities in a functional state of equilibrium which signifies
good health. Any imbalance due to internal or external factors is a disease
and restoring the equilibrium through various techniques, procedures,
regimen, diet and medicine is the treatment.
Indian Systems of Medicine 303
In Ayurveda, diagnosis is done by questioning and examination, viz.

pulse, urine, feces, tongue, eyes, visual/sensual examination and inference.
Treatment in Ayurveda has two complements:
a. Preventive measures
b. Curative measures.
Preventive aspects of Ayurveda is called Avasth Vritt and includes
personal hygiene, appropriate social behavior and Rasayana Sevann, i.e.
use of rejuvenate materials/drugs. The curative treatment consists of
three major categories of procedures:
i. Aushdhi (drug)
ii. Anna (diets)
iii. Vihara (exercises and general mode of life).
SIDDHA SYSTEM OF MEDICINE
Introduction and Origin

Siddha system is one of the oldest systems of medicine in India. The
term 'Siddha' means achievement and 'Siddhas' were saintly figures who
achieved results in medicine through the practice of Yoga. Eighteen
'Siddha's are said to have contribute towards the development of this
medical system Siddha literature is in Tamil and it is practiced in Tamil
speaking parts of India. The system is also called Agasthyar system after
its most famous exponent sage Agasthya. A number of medical works
of this system are ascribed to him. The Siddha system is largely
therapeutic in nature.
Basic Concepts
The principles and doctrines of this system, both fundamental and applied,
have a close similarity to Ayurveda.
According to this system the human body is the replica of the universe
and so are the food and drugs irrespective of their origin. Like Ayurveda,
this system believes that all objects in the universe including human
body are composed of five basic elements namely earth, water, fire, air,
sky. The food which the human body takes and the drugs it uses all
made of these five elements. The proportion of the elements in the drugs
vary and their preponderance or otherwise is responsible for certain
actions and therapeutic results.
Diagnosis and Treatment

The diagnosis of disease involved identifying its cases identification of
causative factors is through the examination of pulse, urine, eyes, study
of voice, color of body, tongue and status of the digestive system of
human body. The system has worked out its colordensity, quantity
and oil drop speeding pattern. Diagnosis involves the study of person,
as a whole, as well as his diseases.
The Siddha system of medicine emphasis the medical treatment is
oriented not merely to disease but has to take into account the patient,
his environment, the meteorological consideration , age, sex, race, habits,
mental frame, habitat, diet, appetite, physical condition, physiological
constitution, etc. This means the treatment has to be individualistic which
ensures lesser chance of committing mistakes in diagnosis or treatment.
UNANI SYSTEM OF MEDICINE
Origin and Development

Unani system of medicine originated in Greece (460BC-377BC). It was
brought to India by Arabs and Persians. Unani is the Arabic name for
Greece which denotes the origin of the system. Hippocrates established
his philosophy of health on the word 'Physis' which meant simply
'Organism' and he postulated that life comprised a reciprocal relationship
between organism and environment. He explained that disease was a
normal process and its symptoms were the reaction of the body to the
disease. The chief function of the physician was to aid the natural forces
of the body. He held that there exists in the body four humorous that
keep up the balance of it. He also laid emphasis on diet and drugs for
cure of diseases.
Fundamental Principles
The Unani system of medicine is based on the Humoral Theory, which
pre-supposes the presence of four humorous namely blood (Dam).
phlegm (Balgham), yellow bile (Safra) and black Bile in the body. The
humours have specific temperament and the temperament of a person is
expressed as being sanguine, phlegmatic, choleric and melancholic
according to their preponderance in the body.
Diagnosis and Treatment

The diagnosis of disease and treatment revolves round the concepts of
temperament of 'Mizaj'. Changes in temperament are related to changes
in the balance of humors. Any change in temperament brings about a
change in the health of the individual. Thus, imbalance in humors and
temperament along with failure of one or more parts of the body to
eliminate pathogenetic waste causes disease.
Treatment is mainly done through drugs of herbal, animal and mineral
origin, which are supposed to have specific temperament (hot, cold, moist,
dry, etc. in different degree). Use of drugs restores balance of humors

by activating self-preservation mechanism in human body. The system
believes in the presence of some natural self-prevention mechanism in
human body. The drugs are supposed to stimulate and strengthen the
action of defence mechanism. In other words, drugs not only normalize
the existing imbalance but also minimize chances of future disease. Thus,
the treatment generally is both curative and preventive.
HOMEOPATHY
Homeopathy is a specialized method of drug therapy of curing natural
diseases by administration of drugs, which have been experimentally,
provide to possess the power of producing similar artificial symptoms
on healthy human beings.
Dr Christian Friedrich Samuel Hahnemann entrained this observation
more thoroughly discovering the fundamental principles of what was
to become Homeopathy. He conducted experiments upon himself, which
went into history as the famous Peruvian Bark Trail. After series of
repeated tests, Hahnemann observed that any substance capable of
producing artificial symptoms on healthy individuals could cure the same
symptoms in natural disease. This forms the basis of the theory of
Homeopathy Simla Similibus Crenature or let like be treated by like.
He published his research works in the classical booksMateria Medica
Pura and Organon the Art of Healing.
Homeopathy is based on the following cardinal principles:
i. The law of similars
ii. The law of direction of cure
iii. The principle of single remedy
iv. The theory of minimum dose
v. The theory of chronic diseases.
The law of similars states that a medicine which can produce artificial
symptoms on healthy human beings can cure the similar set of symptoms
of natural diseases. The direction of cure states that during cultivate
process the symptoms disappear in the reverse order of its appearance
from above downwards, from more important organs, etc. In the
treatment of chronic diseases Homeopathy generally uses only a single
medicine which has a true similarity of symptoms with that of the remedy.
This process of selecting the correct remedy done on the basis of
individualization. The dose applied are the minimum possible dose, just
sufficient to correct the diseased state.
Homeopathy does not give much importance to the nomenclature of
disease for treatment. The concept is that the physical, mental and
spiritual expressions of the sick form the totality of the disease. It is
also believed that the external influences such as bacteria, viruses could
not cause sickness unless the vital resistance of an individual is reduced
beyond a certain level.
In treatment, primary emphasis is given to increasing the
defensive mechanism of the individual through holistic approach
of individualization. Here the treatment is directed in correcting the
imbalance in the immune mechanism and restoring health to the sick.
Here two sick individuals are never considered identical for selection
of medicine, though they may be suffering from the same disease.
Individualization through a detailed and exhaustive case taking is the
most important aspect in homeopathy.
Homeopathy has definite and effective treatment for individuals with
chronic diseases such as diabetes; arthritis; bronchial asthma; skin, allergic
and immunological disorders and for several other diseases, for which
there is less or no treatment in other system.
YOGA
Yoga is a way of life propounded by Patanjali in a systematic form. It
consists of eight components namely restraint, observance of austerity.
Physical postures, breathing exercises, restraining of sense organs,
contemplation, meditation and samadhi. These steps in the practice of
Yoga have potential for improvement of social and personal behavior,
improvement of physical health by encouraging better circulation of
oxygenated blood in the body, restraining the sense organs and thereby
the mind and inducing tranquility and serenity of mind. The practice of
Yoga prevents psychosomatic disorders/diseases and improves individuals
resistance and ability to endure stressful situations. Meditation, one of
the eight components, if regularly pracused, has the capacity to reduce
unwholesome bodily responses to a bare minimum so that the mind can
be directed to perform more fruitful functions.
A number of physical postures are described in Yogic works to improve
bodily health, to prevent diseases and to cure illness. The physical
postures are required to be chosen judiciously and have to be practiced
in the right way to drive the benefits of prevention of diseases, promotion
of health and for therapeutic purposes.
Studies have revealed that the Yogic practices improved intelligence
and memory and help in developing resistance to endure situations of
strain and stress and also to develop an integrated psychosomatic
personality. Meditation is an exercise which can stabilize emotional
changes and prevent abnormal functions of vital organs of the body.
Studies have shown that meditation not only restrain the sense organs
but also controls the autonomic nervous system.
NATUROPATHY
Naturopathy is not only a system of treatment but also a way of life. It
is often referred to as a drugless treatment of diseases. It is based mainly
on the ancient practice of the application of the simple laws of Nature.
The system is closely allied to Ayurveda as far as it fundamental principals
are concerned. There are two schools of thought regarding the approach
to Naturopathy. One group believes in the Indian methods while the
other mainly adopts Western methods, which are more akin to modern
physiotherapy.
The advocates of naturopathy pay particular attention to eating and
living habits, adoption of purificatory measures, use of hydrotherapy,
cold packs, mud packs, baths, massage uses a variety of methods,
measures, based on various innovations.
This system believes that properly boundless organized way of life
and deliver energy, health and happiness. For prevention of disease,
promotion health and to get therapeutic advantages, it is required to
adopt natural means to avoid distortion of nature.
ALLOPATHY
Allopathy is a method of treating disease with remedies that produce
effects different from those caused by the disease itself.
The term allopathy was invented by German Physician Samuel
Hahnemann he referred it to harsh practices of his time which included
bleeding, purging, vomiting and administration of highly toxic drugs.
Four humorous theoryattributed diseases to an imbalance of four
humors (i.e. blood, phlegm and black, yellow bile) and four bodily
conditions (i.e. hot, cold, wet and dry) that corresponded to four
elements (earth, air, fire and water). Physicians follow the Hippocratic
tradition attempted to balance the humors by treating symptoms with
'opposites' during 18th century, it started to loose ground to several
new and conflicting systems that attempted to several one or two basic
causes for all diseases.
It was well known to the physician that their drugs were damaging,
thus by mid century scientific medicine took a back seat.
Methods
Methods are used for:
1. Bleeding 8. Puking
2. Blistering 9. Swatting
3. Plastering 10. Fumigation
4. Leaching 11. Purging
5. Blood letting 12. Ointments
6. Cupping 13. Dehydrations.
7. Poulticing
Chapter
21 Adolescent Health
CHAPTER OUTLINE
PHYSICAL CHANGES DURING ADOLESCENT PUBERTY CHANGES IN ADOLESCENT
EMOTIONAL PROBLEMS EDUCATIONAL PROBLEMS
BENEFICIARIES
INTRODUCTION
The term adolescence is derived from the Latin word "adolescere"
meaning to grow, to mature. It is considered as a period of transition
from childhood to adulthood. They are no longer children yet not adults.
It is characterized by rapid physical growth, significant physical,
emotional, psychological and spiritual changes. Adolescents constitute
22.8 percent of population of India as on 1st march 2000. They are not
only in large numbers but are the citizens and workers of tomorrow.
The problems of adolescents are multi- dimensional in nature and require
holistic approach.
Adolescent has been defined by WHO as the period of life spanning
between 10 to 19 years and the youth as between 15 to 24 years. Young
people, when referred to as such, are those between 10 to 24 years of
age. They are no longer children, but not yet adults.
Population Profile: Ages 10 to 24 Years in India

Population age: 10 to 24 (yrs) 284.2 millions
10 to 24 years as percent of total population 30
Percentage of males enrolld in secondary school 59
Percentage of females enrolled in secondary school 38
Average age at first marrige 20
Percentage of adolescent TFR contributed by 15 to 19 years 9
Percentage of adolescent using contraceptives 7
Characteristics
AAggressive, anemic, abortion
DDynamic, developing, depressed
OOverconfident, overindulging, obese
Adolescent Health 309
LLoud but lonely and lacking information

EEnthusiastic, explorative, and experimenting
SSocial, sexual and spiritual
CCourageous, cheerful, and concern
EEmotional, eager, emulating
NNervous, never say no to peers
TTemperamental, teenage pregnancy.
Early Adolescence (10 to 13 years)

In early adolescent period spurt of growth of development of secondary
sex will take place.
Middle Adolescence (14 to 16 Years)

In middle adolescent period they will have separate identity from
parents, new relationship to peer groups, with opposite sex and desire
for experimentation.
Late Adolescence (17 to 19 Years)

In late adolescent period they will have distinct identity, well formed
opinion and ideas.
The following changes are taking place during adolescent period:
a. Biological changesonset of puberty
b. Cognitive changesemergence of more advanced cognitive abilities
c. Emotional changesself-image, intimacy, relation with adults and
peers group
d. Social changestransition into new roles in the society.
PHYSICAL CHANGES DURING ADOLESCENT
Age group
In girls, physical changes may begin at around 10 years
Reaches their maximum growth by around 14 years
Thereafter, growth continues at slower rate till the age of 18 years
Puberty in boys usually appears later than in girls.
During adolescence there is considerable gain in the weight and height,
it accounts for nearly 20 to 25 percent of adult height and 50 percent of
weight. Puberty height spurt begins at an average age of 12 years for
girls and 14 years for boys.
During puberty girls gain 25 cm height and boys 38 cm height. At the
cessation of growth boys are taller than girls by 13 cm.
PUBERTY CHANGES IN ADOLESCENT
Puberty in Girls
During this period, in female, subjects the secondary sexual characteristics
appear such as appearance of hair in pubic area, and breast begin to grow.
Other changes include accelerated growth and development of genital
organs.
Ovaries begin to ovulate at around 11 to 14 years once every 28 days.
Menarche is the onset of first menstruation which occurs in a young girl
at around 12 years.
Psychological and Behavioral Changes

1. During this transition phase from childhood to adulthood due to
rapid physical and sexual changes in the body, the adolescent
develops anxiety and apprehension.
2. In case they are not given appropriate information and education on
these normal physical, sexual and psychological changes they are
prone to health risk behavior such as sex experiments and drug abuse
leading to teenage pregnancy, contracting RTI/STI, HIV/AIDS, injuries,
accidents, violence, rape, homicides, suicides, etc.
Impact of Adolescence
1. Lack of formal or informal education
2. School dropout and childhood labor
3. Malnutrition and anemia
4. Early marriage, teenage pregnancies
5. Habits and behaviors picked up during adolescence period have
lifelong impact
6. Lot of unmet needs regarding nutrition, reproductive health and
mental health
7. They require safe and supportive environment
8. Desire for experimentation
9. Sexual maturity and onset of sexual activity
10. Transition from dependence to relative independence
Ignorance about sex and sexuality
Lack of understanding
Suboptimal support at family level
Social frustration
Inadequate school syllabus about adolescent health
Misdirected peer pressure in absence of adequate knowledge
Lack of recreational, creative, and working opportunity.
Adolescent Health Problems

1. Anorexia nervosa
2. Obesity and overweight
3. Adolescent pregnancy
4. Micronutrient deficiency
5. Emotional problems
6. Behavioral problems
7. Substance abuse and injuries
8. Sexually transmitted infection
9. Thinking and studying problems
10. Identity problems
11. Respiratory infection, asthma
12. Goiter
13. Bed wetting
14. Dandruff
15. Alopecia
16. Skin patches
17. Pimples
18. Nutritional problem
19. Menstrual problem.
EMOTIONAL PROBLEMS
1. Lack of freedom: Worry about future and career, loneliness. Worries
regarding love marriage and child birth, struggle for identity and
inferiority complex.
2. Lack of confidence: Failed love affairs, stranger anxiety, difficulty in
adjusting with others, parental expectation, problems dealing with
elders.
3. Lack of emotional stability: Depression, suicide, homicidal tendencies.
EDUCATIONAL PROBLEMS
1. Lack of proper counseling and guidance.
2. Inferiority complex due to poor performance in studies.
3. Constant nagging of teachers.
4. Lack of opportunities for preferred profession.
5. Difficulty in adjusting with fellow students.
6. Lack of peer acceptance.
7. Difficulty in talking with teachers.
8. Examination fear.
9. Not achieving academic goals like entrance examination.
10. Stage fear.
Reasons for Adolescent Reluctant to seek Help

Fear
Uncomfortable with of opposite sex health worker
Poor quality perception
Lack of privacy
Confidentiality
Cumbersome procedure
Long waiting time
Parental consent
Operational barrier
Lack of information
Feeling of discomfort.
Prevention
Health education
Skill based health education
Life skill education
Family life education
Counseling for emotional stress
Nutritional counseling
Early diagnosis and management of medical and behavioral problem.
Syllabus for Adolescent Health Education
Development of secondary sexual characters and menarche
Problems associated with menstrual cycle and menstrual hygiene
Body image
Nutritional needs (micronutrients)
Managing emotional stress
Early marriage
RTI/HIV/AIDS
Safe sex
Family life including pregnancy
Child rearing and responsible parenthood
Stress management
Substance abuse.
Inclusion of life skill training in school and college to empower
adolescent in making informed choice to face the complex life situation.
Life Skills
Decision making: Assessing option and what effects different decisions
may have.
Problem solving: Unresolved problems may cause tension.

Creative thinking: Consequences of both action and non-action, looking
beyond direct experience.
Critical thinking: Factors that influence attitudes and behavior.
Effective communication: To express not only opinions and desires but
also needs and fears.
Interpersonal skill: To develop and nurture supportive networks, to be
able to end relationships constructively.
Self-awareness: Recognition of our self-positives and negatives .
Coping with emotions and stress.
Adolescent Friendly Health Center Services

Reproductive health services
Sexual and reproductive health education
Contraception
Pregnancy testing and option
MTP
STD/HIV screening counseling and treatment
Prenatal and postpartum care
Well baby care
Nutritional services
Growth and development monitoring
Anticipatory guidance about substance abuse and other risk taking
behavior
Counseling for life skill development
Screening for various disorders.
Criteria for Adolescent Friendly Health Worker

Welcoming and friendly nature
Knowledgeable
Presentable
Have good communication skill
Maintain confidentiality
Punctuality
Flexibility
Understanding
Good listener
Nonjudgemental.
Criteria for Adolescent Friendly Health Center

Good reception
All facilities
Accessibility
Quality care service
Well trained people
Security
Easy communication to the outside
Privacy
Conducive environment.
Adolescent Girls Scheme

There are two schemes:
Scheme I: Girl-to-girl approach
Scheme II: Balika Mandal.
BENEFICIARIES
Scheme I: Girl-to-Girl Approach
This has been designed for adolescent girl (AG) in the age group 11 to
15 years belonging to families with income level below Rs. 6400/- per
annum and school dropouts in urban and in the rural areas.
These girls are selected per Anganwadi and attached to the local
Anganwadi center for six months duration for learning and training.
These girls act as resource person for other girls in their neighborhood.
Intervention focal point of services is an Anganwadi. These girls are
provided supplementary nutrition equivalent to the entitlement of
pregnant/lactating women for six days in a week.
Simple and practical messages are provided on preventive health,
hygiene, nutrition, working of Anganwadi centers and family life
education. This is provided through initial three days training program,
followed by six continuing education sessions of one day each, every
month. This exercise is aimed at building confidence and encouraging
adolescent girls to become active participants in the development process.
Anganwadi workers act as role models for these girls.
Scheme II: Balika Mandal

All eligible in the age bracket 11 to 18 years irrespective of income
levels of the family are eligible to receive assistance in this scheme;
preference is given to 11 to 15 years age group. In each community
development block and urban ICDS areas 10 percent of total Anganwadi
centers are selected to serve as Balika Mandals 20 girls in the age bracket 11
to 18 are identified. These girls are enrolled for a period of 6 months in
Balika Mandal. Thus, in a year each Balika Mandal will reach out to 40
adolescent girls.
Interventions
These girls are provided supplementary nutrition for six days in a
week to provide 500 calories and 20 g of protein.
Activities cover the areas of personal hygiene, environmental
sanitation, nutrition, home nursing, first aids, communicable diseases,
vaccine preventable diseases, family life, child care and development
and the impact of constitutional rights on the quality of life.
Participate in creative activities and recreation. Learning through
sharing of experiences and discussions on issues that affect their lives.
Training in vocational skills/agro-based skills/household related
appropriate technology.
The Anganwadi worker is regular honorary instructor for the Balika
Mandal and provides general education and literacy to adolescent girls.
She is also responsible for overseeing the work related to skills
improvement/upgradation.
Kishori Shakti Yojna (KSY) has much wider scope than the earlier AG
scheme and involves the entire network of Government of state/union
Territory and district as supportive skills of local self-Government.
Training
Under the AG scheme, a nine days training program has been designed
for selected girls, three days training period is spent at circle headquarter
and remaining six days are devoted for continuing education, spread
over to six months. The training is conducted by supervisors. There are
10 themes for training-environmental sanitation, nutrition, home nursing,
first aid, family life education, child development, legal rights of women,
home economics, positive attitudes and motivation.
The National Population Policy 2000, National Health Policy 2002
identifies the adolescent girls as under-served group for priority
intervention. Similarly, National Nutrition Policy focuses on adolescent
girls to improve their nutritional status, to remove the intergenerational gap.
Chapter
Integrated Disease
22 Surveillance
Project (2004-2009)
CHAPTER OUTLINE
PROJECT OBJECTIVES
SPECIFIC OBJECTIVES
PHASING OF IDSP COVERING THE STATES OF INDIA
SENTINAL SURVEILLANCE UNDER IDSP
REGULAR PERIODIC SURVEY
NATIONAL SURVEILLANCE UNIT
STATE SURVEILLANCE UNIT
DISTRICT LEVEL UNIT
DISTRICT SURVEILLANCE UNIT
DISTRICT EPIDEMIOLOGICAL CELL
LEVELS OF RESPONSE TO DIFFERENT TRIGGERS
SURVEILLANCE OF NONCOMMUNICABLE DISEASES
PROJECT OBJECTIVES
To establish a decentralized state based system of surveillance for
communicable and noncommunicable disease, so that timely and
effective public health action can be initiated in response to health
challenges in the country at the state and national level.
To improve the efficiency of the existing surveillance activities of
disease control programs and facilitate sharing of relevance
information with the health administration, community and other
stakeholders so as to detect disease trends over time and evaluate
control strategies.
SPECIFIC OBJECTIVES
To integrate, coordinate and decentralize surveillance activities
To surveil a limited number of health conditions and risk factors
To establish system for quality data collection, reporting, analysis
and feedback using information technology
To improve laboratory support for disease surveillance
To develop human resources for disease surveillance
To involve all stakeholders including private sector and communities
in surveillance.
PHASING OF IDSP COVERING THE STATES OF INDIA

Phase I (commencing from financial year 2004-2005): Andhara Pradesh,
Himachal Pradesh, Karnataka, Madhya Pradesh, Maharashtra,
Uttaranchal, Tamil Nadu, Mizoram and Kerala.
Integrated Disease Surveillance Project (2004-2009) 317
Phase II (commencing from finacial year 2005-2006): Chhattisgarh, Goa,

Gujarat, Rajasthan, West Bengal, Manipur, Meghalaya, Orissa, Tripura,
Chandigarh, Pondicherry, Delhi
Phase III (commencing from financial year 2006-2007): Uttar Pradesh, Bihar,
Jammu and Kashmir, Jharkhand, Punjab, Arunachal Pradesh, Assam,
Nagaland, Sikkim. Andaman and Nicobar, Dadra and Nagar Haveli,
Daman and Diu, Lakshadweep.
Project Activities
1. Upgradation of laboratories
Renovation and furnishing laboratories
Supply of laboratory equipments
Laboratory material and supplies
2. Information technology and communication
Computer hardware and office equipment
Software for surveillance
Leasing of wide area networking
3. Human resources and development
Consultant/Contract staff
Training
Information education and communication
4. Operational activities and response
5. Monitoring and evaluation.
Diseases and Conditions Covered under IDSP (Table 22.1)

Table 22.1: Diseases and conditions covered under IDSP
Category Disease and condition

Regular surveillance
Vector borne diseases 1. Malaria
Water borne diseases 2. Acute diarrheal disease (Cholera)
3. Typhoid
Respiratory diseases 4. Tuberculosis
Vaccine preventable diseases 5. Measles
Disease under eradication 6. Polio
Other conditions 7. Road traffic accidents
Other international commitments 8. Plague
SENTINAL SURVEILLANCE UNDER IDSP

A. STDs/Blood borne diseases: HIV, HBV, HCV
B. Other conditions: Water quality, air quality.
REGULAR PERIODIC SURVEY

Noncommunicable risk factors:
Antropometry, BP, pulse, tobacco, blindness, BMI, etc.
NATIONAL SURVEILLANCE UNIT

1. Execution of approved annual plan of action.
2. Monitor progress of implementation of project.
3. Obtain reports and expenditure statements from state.
4. Seek reimbursement from world bank.
5. Production of prototype guide lines, manuals, modules.
6. Analysis of data from states and provide feedback on trends observed.
7. Coordinating with other national organizations.
8. Conduct periodic meetings with state surveillance officers.
9. Organize independent evaluation of various activities.
STATE SURVEILLANCE UNIT

Chair person: State Secretary for Health
Analysis of data received by districts and sending it to Central Surveillance
Unit (CSU).
Formation of rapid response teams and deputing them
Coordinating with state public health lab, medical colleges, state level
institutes
Sending regular feedback to districts unit
Coordinating training activity and meetings of state surveillance units.
DISTRICT LEVEL UNIT

1. Chair person: DC or district magistrate
2. Data analysis and transmitting it to State Surveillance Unit (SSU)
3. Constituting rapid response teams
4. Coordinating with other organizations
5. Organizing surveys on infections/noncommunicable diseases and risk
factors
6. Periodic review meetings with State Surveillance Officers.
DISTRICT SURVEILLANCE UNIT (FLOW CHARTS 22.1 TO 22.4)

Functions of the District Surveillance unit
Flow chart 22.1: Chief medical and health officer

Flow chart 22.2: The role of the district within the surveillance system
Flow chart 22.3: District surveillance committee

Flow chart 22.4: District epidemic investigating team (DEIT)
Managerial
Implement and monitor all project activities
Coordinate with laboratories, medical colleges, nongovernmental
organizations and private sector
Organize training and communication activities
Organize district surveillance committee meetings.
Data Handling
Centralize data
Analyze data
Send regular feedback
Outbreak response
Constitute rapid response teams
Investigate.
DISTRICT EPIDEMIOLOGICAL CELL

Reports weekly summary data on disease to state epidemiology
center. It collects all data and pass on monthly summaries to National
Institute of Communicable Disease (NICD).
This cell has one senior officer not below rank of DHO, designated as
District Epidemiology Officer
One medical officer and five field workers per two million or less
population
Cell completes list of all health care institutions, private medical
practitioners in district
All reports are documented, scanned every day to rule out clustering
of cases, analyzed weekly and is forwarded to state epidemiology unit
District cell is responsible for defining and designing interventions

Implements and monitors all project activity in coordination with labs,
private sector and medical colleges
Conducts training and communication activity
Organize district surveillance unit meetings
Triggers in the context of the Indian Integrated Disease Surveillance
Program (IDSP) (Flow chart 22.5)
Threshold for diseases under surveillance that trigger predetermined
actions at various levels
Based upon the number of cases in weekly report
Trigger levels depend on:
Type of disease
Case fatality (Death/case ratio)
Number of evolving cases
Usual trend in the region.
Flow chart 22.5: Structural framework of IDSP
LEVELS OF RESPONSE TO DIFFERENT TRIGGERS (TABLE 22.2)
Table 22.2: Levels of response to different triggers
Trigger significance Levels of response

1. Suspected/limited outbreak Local response by health worker
and medical officer
2. Outbreak Local and district response by
district surveillance officer and
rapid response team
3. Confirmed outbreak Local, district and state
4. Wide spread epidemic State level response
5. Disaster response Local, district, state and center
Malaria Triggers
Trigger 1
Single case of smear positive in an area where malaria was not present
for a minimum of three months
Slide positivity rate doubling over last three months
Single death from clinically/microscopically proven malaria
Single falciparum case of indigenous origin in a free region.
Trigger 2
Two fold rise in malaria in the region over last three months
More than five cases of falciparum of indigenous origin.
Cholera Triggers
Trigger 1
A single case of cholera/epidemiologically linked cases of diarrhea
A case of severe dehydration/death due to diarrhea in a patient of >5
years of age
Clustering of cases in a particular village/urban ward where more
than 10 houses have at least one case of loose stools irrespective of
age per 1000 population.
Trigger 2
More than 20 cases of diarrhea in a village/geographical area of 1000
population.
Typhoid Fever Triggers

Trigger 1
More than 30 cases in a week from the entire primary health center
area
Five or more cases per week from one sub-center of 5,000 population
More than two cases from a single village/urban ward/1000 population
Clustering of cases of fever.
Trigger 2
More than 60 cases from a primary health centre or more than 10 cases
from a subcenter.
Polio Trigger
One single case.
Plague Triggers
Trigger 1
Rat fall
Trigger 2
At least one probable case of plague in community.
Japanese Encephalitis Triggers
Trigger 1
Clustering of two or more similar case from a locality in one week
Trigger 2
More than four cases from a PHC (30,000 population) in one week.
Dengue Triggers
Trigger 1
Clustering of two similar cases of probable dengue fever in a village
Single case of dengue hemorrhagic fever.
Trigger 2
More than four cases of dengue fever in a village with population of
about 1000.
Triggers for Syndromic Surveillance
Fever
More than two similar case in the village (1000 population)
Diarrhea
See cholera
Acute flaccid paralysis
1 case
Jaundice
More than two cases of jaundice in different houses irrespective of
age in a village or 1000 population.
When to Sample?
Isolation of agent, PCR or antigen:
At the earliest
Before antimicrobial administration
For antibody estimation:
Ideally two paired specimens
i. At earliest
ii. After 7 to 10 days
Alternately, one specimen 4 to 5 weeks after onset
Whom to Sample During a Classical Outbreak?

Typical cases
Should represent the majority of the specimens
Untreated patients
Without antibiotics
Cases likely to carry the pathogen
Children
Atypical cases
Few specimens
Healthy contacts
Few specimens.
Rule of Thumb Regarding the Number of Specimens to take during a

Cholera Outbreak
10 specimens to confirm the outbreak
Five specimens per week during the outbreak
Specimens at the end to confirm that the outbreak is over.
How many Specimens to take?

Ensure sufficient number of specimens (At least 20)
Avoid sampling error
Obtain reliable results
Avoid overwhelming the laboratory with excessive specimens
Repeat sampling in some case-patients
Acute and convalescent sera
Exploration of chronic carriage
Intermittent shedding (e.g. Stool microscopy for parasites)
Unknown etiology.
Transport Medium
Allows organisms to survive under adverse conditions
Does not allow organisms to proliferate
Available for bacteria, e.g. Cary Blair
Available for viruses
Virus transport media (VTM).
What is a Viral Transport Medium?

Sterile buffered solution (Pink colored) containing antibiotics for
preservation of viruses
Used in the collection of specimens for viral isolation and testing
Save the viruses from drying

Nutrient, glycerol
Prevents specimen from drying out
Prevents bacterial and fungus growth
Prepared in the lab or commercially obtained
Storage for short periods at 4 to 8C.
Vacutainers
Vacuum tube with rubber stopper mounted on a needle system
Tubes may be changed for collection of different tubes for different
purposes
Smooth blood flow, lower risk of hemolysis
Reduces risk of spillage.
Collecting Blood for Cultures

Collect within 10 to 30 minutes of fever
Aseptic technique
Quantity
Venous blood for infants0.5 to 2 ml
Venous blood for children2 to 5 ml
Venous blood for adults5 to 10 ml
Take three sets of blood culture when suspecting bacterial endocarditis.
To Avoiding Hemolysis for Blood Specimens

Fine needles
Forced suction of blood with syringe
Unclean tube (residual detergents)
Shaking tube vigorously
Forced expulsion of the blood through needle
Freezing/thawing of blood
High speed centrifugation before complete clotting.
Handling and Transporting Blood for Cultures

Collect in blood culture bottles with infusion broth
Change the needle to inoculate the broth
Travel at ambient temperature.
Handling and Transporting Serum

Transport at 4 to 8C if transport lasts less than 10 days
Freeze at 20C if storage for weeks or months before processing and
shipment to reference laboratory
Ship frozen
Avoid repeated freeze-thaw cycles

Destroy IgM (e.g. Measles diagnosis)
Collecting and Handling Cerebrospinal Fluid

Collection
Lumbar puncture
i. Aseptic conditions
ii. Trained person
Sterile tubes
Handling and transportation
For bacteria, transport at ambient temperature or preferably in
trans-isolate medium (pre-warmed to 25-37C before inoculation)
For viruses, transport at 4 to 8C for up to 48 hours or at 70C for
longer duration.
Collecting a Sputum
Instruct patient to take a deep breath and cough up sputum directly
into a wide-mouth sterile container
Avoid saliva or postnasal discharge
Minimum volume should be about 1 ml.
Handling and Transportation of Respiratory Specimens

All respiratory specimens except sputum are transported in appropriate
media
Amies or Stuarts transport medium for bacteria
Viral transport medium for viruses
Transport as quickly as possible to the laboratory to reduce overgrowth
by oral flora
For transit periods up to 24 hours
Ambient temperature for bacteria
For viruses 4 to 8C
Collecting Stool Specimens for Parasites

Timing
As soon as possible after onset
Specimen amount and size
At least 3 5 to 10 ml fresh stool from patients (and controls)
Method
Mixed with 10 percent formalin or polyvinyl chloride, 3 parts of
stool to 1 part preservative
Unpreserved specimens for antigen detection and PCR
Storage
Refrigerate at 4C
Store at 15C for antigen detection and PCR
Transport
4C (Do not freeze)
Dry ice for antigen detection and PCR.
Collecting stool Specimens for Bacteria

Timing
During active phase
Fresh specimens and two swabs from patients, controls and carriers
(if indicated)
Method
In Cary-Blair medium (+ specimen without transport medium for
antigen detection/PCR)
Storage
Refrigerate at 4C if testing within 48 hours, 70C if longer.
Collecting Stool Specimens for Viruses

Timing
Within 48 hours of onset
At least 5 to 10 ml fresh stool from patients (and controls)
Method
Fresh stool unmixed with urines in clean, dry and sterile container
Storage
Refrigerate at 4C. Do not freeze
Store at 15C for antigen detection and protein chain reaction (PCR)
Transport
4C Do not freeze at 4C
Dry ice for antigen detection and PCR.
Rectal Swabs
Advantage
Convenient
Adapted to small children, debilitated patients and other situation
where voided stool specimen collection is not feasible
Drawbacks
No macroscopic assessment possible
Less materials available
i. Not recommended for viruses.
Collecting and Handling Stool Specimens

Take freshly passed stool specimen
Avoid collecting specimen from a bed pan
Collect specimen in sterile container (if available) or clean container
(not cleaned with a disinfectant)
Collecting Serum
Collect venous blood in a sterile test tube
Let specimen clot for 30 minutes at ambient temperature
Place at 4 to 8C for clot retraction for at least 1 to 2 hours
Centrifuge at 1500 RPM for 5 to 10 min
Separate the serum from the clot with pipette/micro-pipette.
Triple-packaging of Specimens: Two Goals

Protect the environment and the carrier
Protect the specimen.
Early Warning Signals for an Outbreak (Flow chart 22.6)

Clustering of cases of deaths
Increase in cases or deaths
Single case of disease of epidemic potential
Acute febrile illness of an unknown etiology
Two or more linked cases of disease with outbreak potential
(e.g. measles, cholera, dengue, Japanese encephalitis or plague)
Unusual isolate (Cholera O 139)
Shifting in age distribution of cases (Cholera O 139)
High vector density
Natural disasters.
Flow chart 22.6: Components of early warning surveillance

Steps in Outbreak Response (Flow chart 22.7)

1. Verifying the outbreak
2. Sending the rapid response team
3. Monitoring the situation
4. Declaring the outbreak over
5. Reviewing the final report.
Step 1: Verifying the Outbreak

Validate the source of information
Change in the reporting system
Change in the population size
Acute reporting of old, chronic cases
Check with the concerned medical officer
Abnormal increase in the number of cases
Clustering the cases
Epidemiological link between cases
Triggering event
Deaths
Step 2: Sending the Rapid Response Team

Review if the source and mode of transmission are known
If not, constitute team with:
Flow chart 22.7: Investigation of an epidemic
Medical officer
Epidemiologist
Laboratory specialist
Formulation of hypothesis on basis of the description by time, place
and person (Descriptive epidemiology)
Does the hypothesis fits the fact
Yes: Propose control measures
No: Conduct analytical studies.
The rapid response team:
Composition
Epidemiologist, clinician and microbiologist
i. Entomologist when vector-borne disease
Gathered on ad hoc basis when needed
Role
Confirm and investigate outbreaks
Responsibility
Assist in the investigation and response
Primary responsibility rests with local health staff
Monitoring the situation:
Trends in cases and deaths
Implementation of containment measures
Stocks of vaccines and drugs
Logistics
Communication
Vehicles
Community involvement
Media response.
Declaring the Outbreak Over

Role of the district surveillance officer/medical health officer
Criteria
No new case during two incubation periods since onset of last case
Implies careful case search to make sure no case are missed.
Review of the Final Report

Sent by medical officer of the primary health center to the district
surveillance officer/medical and health officer within 10 days of the
outbreak being declared over
Review by the technical committee
Identification of system failures
Longer term recommendations
Control Measures for an Outbreak

General measures
Till source and route of transmission identified
Specific measures, based upon the results of the investigation
Agent
i. Removing the source
Environment
i. Interrupting transmission
Host
i. Protection (e.g. immunization)
ii. Case management.
Sources of Information to detect Outbreaks

Event-based surveillance
Rumor register
i. To be kept in standardized format in each institution
ii. Rumours need to be investigated
Community informants
i. Private and public sector
Media
i. Important source of information, not to neglect
Case-based surveillance
i. Review of routine surveillance data and triggers
Outbreaks versus Epidemics

Occurrence of cases of an illness in excess of expected numbers
Scale
Outbreak
i. Limited to a small area, within one district or few blocks
Epidemic
i. Covers larger geographic areas
ii. Linked to control measures in district/state
No exact precise threshold: Use a word or the other according to
whether you want to generate or deflect attention
i. Be aware of legal implications of the use of the term Epidemic
in India (Epidemic Disease Act, being revised)
Endemic versus epidemic
Endemicity
i. Disease occurring in a population regularly at a usual level
Tuberculosis, Malaria
Epidemics
Unusual occurrence of the disease in excess of its normal expectation
i. In a geographical location
ii. At a given point of time
For example, hepatitis E, measles, cholera
SURVEILLANCE OF NONCOMMUNICABLE DISEASES
Aims
1. To monitor trends of important risk factors of NCDs in community
over a period of time.
2. Evolve strategies for intervention of these risk factors so as to reduce
the burden of diseases due to NCDs.
3. Strengthen NCD surveillance and integrate risk factors surveillance.
NCD Risk Factors

1. Behavioral: Tobacco, alcohol, diet habits
2. Physical: Levels of inactivity
3. Biochemical: Blood sugar, cholesterol
4. Measurements: Height, weight, pulse, BP, wiast circumference
Program for Control and Treatment of Occupational Diseases

Major occupational illness are listed based on three criterias:
1. Frequency
2. Severity
3. Potential for prevention.
List
Occupational injuries
Occupational lung disorders
Occupational cancer
Occupational dermatoses
Occupational toxicology
Occupational mental illness.
Etiological Classification of Occupational Disorders

1. Chemical: Dust, gases, acids, alkali, metals.
2. Biological factors
3. Behavioral factors
4. Social occupational factors.
5. Physical: Noise, heat, radiation.
Proposed Projects for Occupational Diseases under National

Program for Control and Treatment of Occupational Diseases
1. Prevention, control, treatment of silicotuberculosis
2. Occupational health problems of tobacco harvestors
3. Hazardous process and chemicals database generation, documentation

and information dissemination.
4. Capacity building to promote research, education, training at National
Institute.
Global Strategy of Occupational Health (Fig. 22.1)

Developing healthy work environment and healthy work practices to
promote health at work.
Strengthening occupational health services
Support services for occupational health
Developing health standards on scientific risk assessment.
Developing human resources for occupational health
Strengthening research and developing collaboration in occupational
health services and organizations.
Strengthening international and national policies.
Monitoring and Evaluation
Monitoring
1. Number and percent of districts providing monthly surveillance
reports on time by state and overall.
2. Number and percent response to disease specific triggers on time by
state and overall.
Fig. 22.1: Recommendations link field epidemiology and program management

3. Number and percent of labs providing adequate quality of information

by state and center.
4. Number of districts in which private providers are contributing to
disease information
5. Publication by CSU of consolidated annual surveillance report.
Evaluation
1. Baseline study: Existing quality of lab services and waste management
practice.
2. Sample surveys: Surveys of risk factors of NCDs.
3. Mid-term evaluation: Evaluation of training activities at various levels.
4. Trends on lab quality assurance and waste management practices.
5. End line evaluation: Evaluation of training activities at various levels.
6. Effectiveness information technology in surveillance, cost-benefit
analysis of a project.
Chapter
Integrated Management
23 of Neonatal and
Childhood Illnesses
CHAPTER OUTLINE
COMPONENTS OF IMNCI IN INDIA IMNCI STRATEGY IN INDIA
INTRODUCTION
Most illness contributing to under five deaths are preventable. Only a few,
mostly developing countries, account for a large proportion of child deaths
worldwide. Internationally, there has been a call to reduced burdens
contributing to infant, neonate, child morbidity and mortality such as
the world summit for children (1990) and the Millennium Development
Goals (2001). From this, the Integrated Management of Childhood Illness
(IMCI) strategy was developed by WHO, UNICEF and other agencies,
institution and individuals to address issues related to morbidity among
children under five years of age.
Problem Statement
In India 2.1 million children die before reaching the age of 5 years
India accounts for one-fifth of the global child morbidity burden
IMR60 to 7 per 1000 live births of which two-third are neonates.
NMR40 to 45 per 1000 live births.
National Goals of India by 2015
IMR27 and NMR20.
COMPONENTS OF IMNCI IN INDIA

1. Care of newborns and young infants (<2 months)
2. Care of infants and children (2 months to 5 years)
3. Home visits
4. Skill based training
5. Strengthening the Health Systems and Referral
6. Improvements of family and community practices
7. Collaboration with other departments, PRIs, SHGs, MSS.
IMNCI STRATEGY IN INDIA

Implementation of Integrated Management of Neonatal and Childhood
Illness, in the district is a component of the Child Health Strategy under
the National Rural Health Mission/Reproductive and Child Health

Program Phase II. The IMNCI strategy has been developed by child
health researchers, academicians, the Indian Academics of Pediatrics
(IAP) and National Neonatology Forums (NNFs). According to
operational guidelines developed by the Indian Ministry of Health and
Family Welfare, Governments of India, the IMNCI package includes the
following components:
I. Care of newborns and young infants (under-two months):
Keeping the baby warm
Initiation of breastfeeding immediately after birth and counseling
for exclusive breastfeeding and non-use of prelacteal feeds
Cord, skin and eye care
Recognition of illness in newborn and management and/or
referral
Immunization
Home visits in postnatal period.
II. Care of infants (2 months and 5 years):
Management of diarrhea, acute respiratory infections (pneumonia),
malaria, measles, acute ear infection, malnutrition and anemia
Recognition of illness, risk conditions and their management and
referral
Prevention and management of iron and vitamin A deficiency
Counseling on feeding for malnourished children between two
to five years
Immunization.
III. Home visits: Home visits made by ANMs, ASHAs and link volunteers
are integral part of this intervention which help mothers and families
to understand and provide essential newborn care at home.
IV. Training: IMNCI involves two categories of skill based training.
One for medical officers and a second for front Line functionaries
including ANMs and AWWs. For ASHA and link volunteers if any
a separate package focusing on home care of newborn and children
is being prepared.
V. Improvements to health systems: Essential elements include:
Ensuring availability of essential drugs
Improves referral to identified referral health facility
Referral mechanism to ensure that an identified sick infant or
child can be swiftly transferred to a higher level of care
Functioning referral centers, especially where health care systems
are weak, referral institutions need to be reinforced or private/
public need to be established
Ensuring availability of health workers/providers at all levels.
Integrated Management of Neonatal and Childhood Illnesses 337
Ensuring supervision and monitoring follow-up visits by trained

supervisors.
VI. Improvements of family and community practices: Counseling of
families and creating awareness among community on healthy
behaviors through IEC campaigns and counseling of caregivers and
families as part of management of the sick child.
VII. Collaboration/Community Medicine coordination with other
departments, PRIs, Self-Help Groups, MSS, etc.
Globally
Integrated Management of Childhood Illness (IMCI)
India
Integrated Management of Neonatal and Childhood Illness (IMNCI)
(Table 23.1)
Table 23.1: Integrated management of neonatal and childhood illness
Feature Generic IMCI Indian IMNCI

Coverage of 0-6 days No Yes
(early new born period)
Basic health worker module No Yes
Home visit module by provider for care No Yes
of new born and young infants
Home based training No Yes
Duration of training on newborn/ 2 of 11 days 4 of 8 days
young infant
Sequence of training Child first then Newborn/young
young infant infant then children
Timeline of IMNCI
1. Instrument Development (July-Sep, 2006)
2. Program Managers Meeting (August, 2006)
3. International Advisory Board meeting (September, 2006)
4. National Orientation and Protocol Finalization Workshop (September,
2006)
5. Second International Advisory Board meeting (November, 2006)
6. Regional Training Workshops (February-March, 2007)
7. Data Collection (March-May, 2007)
8. Data Analysis (ongoing)
9. Draft Report Writing (ongoing)
10. Dissemination of Results (July, 2009)
11. Final Report (August, 2009).
The IMNCI-PLUS
The objective of IMNCI-PLUS strategy in RCH II are to implement by
2010, a comprehensive newborn and child health package at the level
of all subcenters (through ANMs). Primary health centers (through
medical officers, nurse and LHVs) and first referral units (through
medical officers and nurses).
Implement by 2010 a comprehensive newborn and child health package
at household level in 250 districts (through AWWs).
Chapter
Community-based
24 Rehabilitation
CHAPTER OUTLINE
HARD FACTS NEED OF REHABILITATION SERVICE
INTRODUCTION
Community-based Rehabilitation (CBR) strategy was developed by the
WHO after 1978. Alma Ata declaration, which stated that comprehensive
primary health care, should include promotive, preventive, curative and
rehabilitative care. The major objective of CBR is to ensure that people
with disabilities (PWD) are able to maximize their physical and mental
abilities, have access to regular services and opportunities and achieve
full social integration within their communities. CBR is a comprehensive
approach, which encompasses disability prevention and rehabilitation
in primary health care activities and integration of disabled children in
ordinary school and provision of opportunities for the gainful economic
activities for disabled adults.
Community-based Rehabilitation (CBR) may be defined, according
to three United Nation Agencies, ILO, UNESCO, and the WHO, as a
strategy within community development for the rehabilitation,
equalization of opportunities, and social integration of all people with
disabilities. CBR is implemented through the combined efforts of disabled
people themselves, their families and communities, and the appropriate
health, education, vocational and social services.
HARD FACTS
One billion population distributed over 27 states and 7 union territories
that are further divided into 557 administrative units called districts.
About five percent persons with disabilities.
Seventy eight percent population lives in rural areas.
Fifteen percent people who live in urban areas have access to some
kind of rehabilitation service whereas in rural areas it is only one percent.
On average 5 to 10 percent person with disabilities has access to basic
rehabilitation services.
NEED OF REHABILITATION SERVICE

Only 15 percent people living in urban areas and three percent people
living in rural areas can avail rehabilitation service in India, total coverage
according Ministry of Social Justice and Empowerment is only 5.7 percent
Seven National Levels Institutes

National Institute for the Visually Handicapped, Dehradun
National Institute for the Hearing Handicapped, Mumbai
National Institute for the Mentally Handicapped, Secunderabad
National Institute for the Orthopedically Handicapped, Kolkata
National Institute of Rehabilitation Training and Research, Cuttack
Institute for the Physically Handicapped, New Delhi
National Institute for the Empowerment with Persons with Multiple
Disabilities, Chennai
Government Rehabilitation Services

The Ministry of Social Justice and Empowerment is the nodal agency of
the Central Government that promotes services for the people with
disabilities through its various schemes.
Objectives
The primary object is to promote services for people with disabilities
through government and non government organizations, so that they
are encouraged to become functionally independent and productive
members of the nation through opportunities of education, vocational
training, medical rehabilitation, and socioeconomic rehabilitation.
Emphasis is also placed on coordination of services particularly those
related to health, nutrition, education, science and technology, employment,
sports, cultural, art and craft and welfare programs of various government
and nongovernment organizations.
District Rehabilitation Center (DRC) Project
Regional Rehabilitation Training Center (RRTC)
National Information Center on Disability and Rehabilitation (NICDR)
National Council for Handicapped Welfare
National Handicapped Finance and Development Corporation
Assistance through Overseas Development Administration, UK
Training in the UK under the Colombo Plan
UNICEF Assistance in collaboration with the Government of India
National Awards.
District Rehabilitation Center (DRC) Project

The District Rehabilitation Center scheme was launched in early 1985
to provide comprehensive rehabilitation services to the rural disabled.
Community-based Rehabilitation 341
This was done in collaboration with the National Institute of Disability

and Rehabilitation Research (NIDRR), Washington, USA. A Central
Administrative and Coordinaiton Unit (CACU) for coordinating and
administering the activities of DRC was setup.
The aims and objectives of the DRCs include surveys of disabled
population, prevention, early detection and medical intervention and
surgical correction, fitting of artificial aids and appliances, therapeutic
servicesphysiotherapy, occupational therapy and speech therapy,
provision of educational services in special and integrated schools,
provision of vocational training, job placement in local industries and
trades, self-employment opportunities, awareness generation for the
involvement of community and family to create a cadre of multi-
disciplinary professionals to take care of major categories of disabled in
the district. At present, 11 DRCs function in 10 states in India.
Regional Rehabilitation Training Center (RRTC)

Four Regional Rehabilitation Centers have been functioning under the
DRCs scheme at Mumbai, Chennai, Cuttack and Lucknow since 1985 for
the training of village level functionaries, training of DRCs professionals,
orientation and training of State Government officials, research in service
delivery and low cost aids, etc. Apart from developing training material
and manuals for actual field use, RRTCs also produce material for creating
community awareness through the medium of folders, posters, audio-
visuals, films and traditional forms.
National Information Center on Disability and Rehabilitation (NICDR)

A National Information Center on Disability and Rehabilitation was set
up under CACU in 1987 to provide a database for comprehensive
information on all facilities and welfare services for the disabled within
the country. It also acts as a nodal agency for awareness creation,
preparation/collection and dissemination of materials/information on
disability relief and rehabilitation. The computerized data so far collected
relates to institutions/professionals working for the disabled, aids and
appliances, scholarships, national awards and physical/financial
performance of DRCs/RRTCs. It publishes the Indian Journal of Disability
and Rehabilitation.
The Media Cell is responsible for the publication of awareness-
generation material/journals, hold seminars/workshops, organization
of film festival/exhibitions, production of films, etc. UNICEF assistance
is obtained for different activities on awareness creation.
Proposed Program for Rehabilitation of the Disabled in the Ninth

Five-year Plan
At the Gram Panchayat level the local panchayat committee will
manage the CBR program. Preferably, two CBR workersone male
and one female, for about 5,000 population, may be employed and
suitably trained at the Gram Panchayat level.
At the PHC level 2 multirehabilitation workers (MRWs) for about
30,000 population will be responsible to provide services to the persons
with disabilities. They will provide information to community leaders,
to the persons with disabilities and their families about disability.
They will also provide services and opportunities using already
available resources. The MRW will cooperate with PHC, education,
labor, NGOs and other persons, which will make services available
and open opportunities for PWDs. They will also make appropriate
referral of cases to the District Rehabilitation Center (DRC).
At the district level DRC will be headed by District Rehabilitation
Officer who will monitor and guide the work carried out at peripheral
levels. Functionaries of the department of rural development, social
welfare, labor and employment and women and child development
will also provide specialist services at the district level.
At the state level, an apex level institution will be set up to serve as
resource center in the field of disability prevention and rehabilitation.
This institute will train the functionaries of DRCs, PHCs and CHCs.
The institute will also undertake long and short term training program
to develop the manpower required in the state for the delivery of
rehabilitation services. It will also establish linkages with the existing
medical professionals, training and employment infrastructure and
also promote and conduct research in the area of disability prevention
and rehabilitation.
At the national level, it is proposed that there should be a national
center for disability rehabilitation under the national program of
rehabilitation.
Role of Primary Health Centers for Disability Rehabilitation

Various services for persons with disabilities in India are very short in
supply and do not cover more than even one percent of the entire disabled
population. In order to face the challenges of increased population and
the lack of proper services to match the needs and expectations of the
persons with disability, their family members and the society as a whole,
a suitable framework having wide coverage has to be developed in the
country for effective management of the disabled. It is in view of these
primary and basic needs, the primary health center (PHC) network in
India assumes great importance. A PHC is the only existing minimum
necessary infrastructure to provide various disability prevention and
rehabilitation services. By sensitizing the medical officers and health
teams in PHCs on some of the important aspects of disability prevention,
early identification, referral and rehabilitation, valuable services could
be rendered to people with disabilities in the rural areas.
Primary health care in India is provided by a network of primary

health centers and its subcenters in rural areas and health posts in
urban areas. Health workers at subcenters get help from village health
guides (VHGs), traditional birth attendants (TBAs) and Anganwadi
workers in their functioning. This huge manpower can help in
identification of disabled along with CBR workers and community level
functionaries of DRC with the help of training packages developed by
WHO.
Multi-rehabilitation workers (MRWs) at PHC with the help of Medical
Officer will attend to referred disabled and help in training of personnel
engaged at subcenter and village level. Vocational rehabilitation centers
will provide support in relation to generating various occupational
opportunities for disabled along with NGOs and other concerned
personnel at district level.
Model Method of Implementation of CBR Using Primary Health Centers

Community level functionaries (CLF) at village and subcenter level for
a population of 5000. The village rehabilitation committee (VRC) of the
Panchayat members will manage the activities.
Manpower
Person with disabilities
Family trainee
Community rehabilitation worker
MPHW male and female
VHG, TBA and Anganwadi worker
NGOs, teachers and volunteers.
Functions
Micromanagement
Community preparation
Resources
Monitoring.
Tasks
Locate and identify PWD
Referral
Assess functions and activities
Select training material and trainees
Teach and motivate family training
Increased acceptance by family
Facilitate school admission
Refer to social and vocational organization
Assess record and report results to VRC

Stimulate awareness of community about disability.
Continuing education for CLF and teach them about health care needs
of disabled persons.
At PHC and CHC level for a population of 30,000 to 1 lakh. The
Medical Officer-in-charge of PHC and CHC will manage the activities.
Manpower
Multirehabilitation worker (MRW)
Health assistant male and female.
Functions
Provide technical training, supervision and support of CBR program
Report on effectiveness of CBR center
Provide first level referral advice and refer to higher level if required
Interact with middle level personnel in other sectors like social,
education and labor and coordinate supports to community.
Orientation of Medical Officers Working in

Primary Health Centers to Disability Management
Rehabilitation Council of India has launched the National Program on
Orientation of Medical Officers working in Primary Health Centers to
Disability Management on 15th July 1999, with a view that the Medical
Officers of PHCs could be trained in various disability issues, PHC is
the only health infrastructure, which is spread over the country. Training
the Medical Officers in Disability Prevention and Rehabilitation can bring
significant benefits to the persons with disabilities. Most of the disable
people live in the rural areas with very poor infrastructure for providing
rehabilitation services. In view of such gross neglect of rural areas, this
program has been designed for rural disabled.
The program is being implemented in two stages. In the first stage, a
master training program is imparted in each state to a team of medical
practitioners/rehabilitation professionals working in the institutions
selected to conduct the master training program. In the second stage,
the trained Master Trainer's Services are utilized for taking up the training
of the Medical Officers working in the PHCs. The ingenuity of program
is the utilization of the rehabilitation professionals taken from all the
disability areas for the training of Medical Officers. This has been
consciously done with a view to add thrust to program by way of
transferring the rich knowledge and experience of these professionals
to the Medical Officers regarding various intricate disability issues.
Another notable feature of the program is the selection of institutions,
which have rich experience and possess laboratories in one or more
areas of disability. This not only gives an opportunity to the doctors to

observe themselves the various facets of disability and also allow them
to gain practical insight into managing the problems in the locality
covered under their PHCs.
Expected Benefits of the Program

1. The program is expected to generate in the country, the following
benefits in the short as well as in the long run.
2. Large scale direct benefit of various services like prevention, early
identification, referral and rehabilitation to the rural population.
3. Wide and improved service network for the persons with disabilities
even in the remotest corners of the country.
4. Decrease in the severity and extent of disability in millions of cases.
5. Increase in the GDP, as the impact of disability prevalence will be less.
6. Awareness generation among the Health Workers through the PHC
Medical Officers which will percolate to the lowest level as the lower
level health workers function within the community.
7. Social and economic empowerment of the persons with disability.
8. Leadership building in the PHC Medical Officers to help create better
sensitization at the grass root level which will ultimately ensure better
implementation of the Persons with Disabilities Act, 1995.
BIBLIOGRAPHY
1. Disability Prevention and Rehabilitation in primary health carea guide
for district health and rehabilitation managers. Rehabilitation, WHO, 1995.
2. National programme on orientation of medical officers working in primary
health centres to disability management-status of implementation 2001,
Rehabilitation Council of India.
3. Proceedings of workshop on Community-based Rehabilitation WHO
sponsoreddepartment of Physical Medicine and Rehabilitation,
Safdarjang Hospital, New Delhi, 1997.
4. The Persons with Disabilities (equal opportunities, protection of rights and
full participation) Act 1995Ministry of Law, Justice and Company affairs.
Chapter
25 Social Security
CHAPTER OUTLINE
WORKFORCE IN INDIA
FUNCTIONS OF SOCIAL SECURITY DIVISION
INTRODUCTION
Social security protects not just the subscriber but also his/her entire
family by giving benefit packages in financial security and health care.
Social security schemes are designed to guarantee at least long-term
sustenance to families when the earning member retires, dies or suffers
a disability. Thus, the main strength of the social security system is that
it acts as a facilitatorit helps people to plan their own future through
insurance and assistance. The success of social security schemes, however,
requires the active support and involvement of employees and employers.
In the Indian context, social security is a comprehensive approach
designed to prevent deprivation, assure the individual of a basic
minimum income for himself and his dependents and to protect the
individual from any uncertainties. The state bears the primary
responsibility for developing appropriate system for providing protection
and assistance to its workforce. Social security is increasingly viewed as
an integral part of the development process. It helps to create a more
positive attitude to the challenge of globalization and the consequent
structural and technological changes.
WORKFORCE IN INDIA
The dimensions and complexities of the problem in India can be better
appreciated by taking into consideration the extent of the labor force in
the organized and unorganized sectors.
Organized and Unorganized Sectors

The organized sector includes primarily those establishments which are
covered by the Factories Act, 1948, the Shops and Commercial
Establishments Acts of State Governments, the Industrial Employment
Standing Orders Act, 1946, etc. This sector already has a structure through
which social security benefits are extended to workers covered under
these legislations.
Social Security 347
The unorganized sector on the other hand, is characterized by the

lack of labor law coverage, seasonal and temporary nature of occupations,
high labor mobility, dispersed functioning of operations, casualization
of labor, lack of organizational support, low bargaining power, etc. all
of which make it vulnerable to socioeconomic hardships. The nature of
work in the unorganized sector varies between regions and also between
the rural areas and the urban areas, which may include the remote rural
areas as well as sometimes the most inhospitable urban concentrations.
In the rural areas it comprises of landless agricultural laborers, small
and marginal farmers, share croppers, persons engaged in animal
husbandry, fishing, horticulture, bee-keeping, toddy tapping, forest
workers, rural artisans, etc. where as in the urban areas, it comprises
mainly of manual laborers in construction, carpentry, trade, transport,
communication, etc. and also includes street vendors, hawkers, head
load workers, cobblers, tin smiths, garment makers, etc.
FUNCTIONS OF SOCIAL SECURITY DIVISION
List of Subjects
Matters concerning framing of social security policy especially for the
organized sector of workers.
Administration of Employees' State Insurance Act, 1948.
Administration of the Employees' Provident Funds and Miscellaneous
Provisions Act, 1952 and three schemes framed there under, namely:
The Employees' Provident Fund Scheme, 1952
The Employees' Pension scheme, 1995
The Employees' Deposit linked Insurance Scheme, 1976.
Workmen's Compensation Act, 1923.
Maternity Benefits Act, 1961.
Payment of Gratuity, Act, 1972.
Establishment matters relating to the Employees' State Insurance
CorporationConstitution of ESI Corporation, Standing Committee
and Medical Benefit Council of ESIC as also Regional Board.
Administrative matters of ESI Corporation including implementation
of ESI Scheme in New Geographical Areas, opening of Sub-Regional
Offices of ESIC and up-gradation of medical facilities.
Annual report, budget and accounts, and matters connected with
auditing of accounts of the ESIC and EPFO
Issues relating to International Social Security Association (ISSA); and
other International Social Security Organizations. Processing of ILO
Conventions relating to social security.
All parliamentary matters and MP/VIP References in relation to the
above as also legislative matters/amendment in respect of the aforesaid
Acts.
Vigilance matters/Disciplinary proceedings relating to officers of EPFO

and ESIC.
Representations from employees of ESIC and EPFO, and general public
grievances on ESIC/EPFO/Social Security measures in India.
All matters relating to setting up of EPF Appellate Tribunal-
establishment matters and appointment of staff.
Constitution of the Central Board of Trustees and Regional
Committees, EPFO.
All matters relating to:
Pattern of investment of provident fund money.
Declaration of rate of interest on the provident fund.
Enhancement of the rate of provident fund contributions.
Budget of the EDLI Scheme and EPS;
Payment of central government contribution and administrative
charges for Family Pension Scheme, Deposit Linked Insurance under
the EPF Act as well as the Assam Tea Plantation Provident Fund
Act.
References relating to recovery of EPF/ESI dues/exemptions and
Exclusions from the EPF and MP Act and also the ESI Act.
EPFO Programs at a Glance (Table 25.1)
Table 25.1: EPFO programs at a glance

Program name Program type Financing Coverage
Employees Mandatory Employer: 1.673.67% Firms with + 20
provident fund Employee: 1012% employees
Government: None
Employees Mandatory Employer: 8.33% Firms with + 20
pension Employee: None employees
scheme (EPS) Government: 1.16%
Employees deposit Mandatory Employer: 0.5% Firms with+20
linked insurance Employeees: None employees
Scheme (EDLI) Government: None
ESI contribution rates

Employees: 1.75 percent of wages
Employers: 4.75 percent of wages
State Govts.: 1/8th share of expenditure.
A few examples of other retirement programs giving social security
(Table 25.2).
(Information on extent of coverage of the labor force under these
programs is not available).
Social Security 349
Table 25.2: Retirement programms in social security
Program name Program type Financing Coverage

Civil service Mandatory State or central Civil servants at state and
pension scheme Government central government level
Government Mandatory Employee Civil servants at state and
provident fund contribution central government level
Special provident Mandatory Employer and Applies to worker in
particular funds employee sectors: Coal, mines, tea
contributions plantation, Jammu and
Kashmir seamen, etc.
Public provident Voluntary Contributions All individuals are eligible to
fund apply
Personal pension Voluntary Contributions Employees as decided by
respective establishments
Personal pension Voluntary Purchase of All individuals
annuity type
products
State level social Government State Varies by state and type of
assistance sponsored Government scheme
social
assistance
National old age Government Central Poor persons above age 65
pension scheme sponsored Government
social
assistance
New Initiative in Social Security

Varishtha Pension Bima Yojana (VPBY): This scheme proposed in the 2003-
04 budget by the Ministry of Finance is to be administered by the Life
Insurance Corporation of India (LIC). Its main features are summarized
below:
Under VPBY, any citizen above 55 years of age could apy a lump-sum
and get a monthly pensions are pegged at Rs. 250 and Rs. 2000 per
month respectively. These amounts are not indexed to inflation.
There is a guaranteed return of nine percent per annum for this
scheme.
The difference between the actual yield by the LIC under this scheme
and the 9 percent will be made up by the central government.
The EPF and MP Act is proposed to be amended suitably to allow EPF
subscribes to invest in the VBPY.
Chapter
26 Swine Flu
CHAPTER OUTLINE
TRANSMISSION SIGNS AND SYMPTOMS
INTRODUCTION
Swine influenza was first proposed to be a disease related to human
influenza during the 1918 flu pandemic. When pig became sick at the
same time as human. The first identification of an influenza virus as a
cause of disease in pigs occurred about ten years later, in 1930. For the
following 60 years, swine influenza strain were almost exclusively H1N1.
Then, between 1997 and 2002, new strain of three different subtype and
five different genotype emerged as cause of influenza among pigs in
North America. In 1997 to 1998, H3N2 strain emerged. These strain, which
include genes derived by reassortment from human, swine and avian
virus, have become a major cause of swine influenza in North America.
Outbreak in Human, 2009

The H1N1 viral strain implicated in 2009 flu pandemic among human
often is called swine flu because initial testing showed many of genes
in the virus were similar to influenza viruses normally occurring in North
American swine.
TRANSMISSION
The main route of transmission is through direct contact between infected
and uninfected animals. These close contacts are particularly common
during transport. Intensive farming may also increase the risk of
transmission, as the pigs are raised in very close proximity to each other.
The direct transfer of the virus probably occurs either by pigs touching
noses or through dried mucus. Airborn transmission through the aerosols
produced by pigs coughing or sneezing are also an important means of
infection. The virus usually spread quickly through a herd, infect all the
pigs within a few days. Transmission may also occur through wild
animals, such as:
Transmission to Human
People who work with poultry and swine, especially people with intense
exposures, are at increased risk of zoonotic infection with influenza virus
Swine Flu 351
endemic in these animal and constitute a population of human host in

which zoonosis and reassortment can co-occur.
SIGNS AND SYMPTOMS

The symptoms of swine flu H1N1 virus are similar to those of influenza
and of influenza like illness in general. Symptoms include fever, cough,
sore throat, body aches, headache, chills, and fatigue. The 2009 outbreak
has shown an increased percentage of patient reporting diarrhea and
vomiting.
Cause of Death
Common cause of death is respiratory failure. Other cause of death are
pneumonia (leading to sepsis) high fever (leading to neurological
problem), dehydration (excessive diarrhea and vomiting) and electrolyte
imbalance. Fatality are more likely in young children and the elderly.
Prevention
i. Prevention in swine
ii. Prevention of transmission to human
iii. Prevention of its spread among humans.
Prevention in Swine
i. Facility management
ii. Herd management
iii. Vaccination.
Facility Management
Facility management includes using disinfectant and ambient temperature
to control virus in environment.
Herd Management
Herd management includes not adding pigs carrying influenza to herds
that have not been exposed to the virus. The virus survives in healthy
carrier pigs for upto three months.
Prevention of human-to-human transmission: Frequent washing of hands
with soap and water or with alcohol-based hand sanitizers, especially
after being out in public.
Social distancing is another tactic. It means staying away from other
people who might be infected and can include avoiding large gatherings,
spreading out a little at work or perhaps staying home and lying low if
an infection is spreading in a community.
Treatment in human being: If the person become sick with swine flu, antiviral
drugs can make illness milder and make the patient feel better faster.
They may also prevent serious flu complications. For treatment antiviral
drugs work best if started soon after getting sick (within 2 days of
symptoms). Beside antivirals, supportive care at home or in hospital,
focuses on controling fevers, relieving pain and maintaining fluid balance,
as well as indentifying and treating any secondary infections or other
medical problems. The US Centers for Disease Control and Prevention
recommends the use of Tamiflu (oseltamivir) or Relenza (zanamivir) for
the treatment and prevention of infection with swine influenza viruses;
however, the majority of people infected with the virus make a full
recovery without requiring medical attention or antiviral drugs. The
virus isolates in the 2009 outbreak have been found resistant to
amantadine and rimantadine.
Chapter
27 Hospital Statistics
CHAPTER OUTLINE
DAILY ANALYSIS MONTHLY REPORTS
CENSUS DEATH RATE
DAILY ANALYSIS
Daily census of admissions, births, transfer in, transfers out and death
complied by ward and by specialty.
Daily discharge analysis.
MONTHLY REPORTS
Summary of outpatient visits (first and repeat).
Summary of inpatient activity speciality wise: number of admissions,
discharges, death, hospital days, mean length of stay, bed turnover
ratio, occupancy rate, mortality rate, operations, infections, specialized
procedures.
CENSUS
Inpatient bed occupancy ratio:
Total inpatient service days for a period 100
Total inpatient bed count number of days for a period
Average daily newborn inpatient service days for a period. Total
number of days in the period.
DEATH RATE
Hospital death rate (Gross death rate):
No. of inpatient deaths in a period
= 100
No. of discharges (including deaths) in the same period
Postoperative death rate:
Total no. of deaths within 10 days postoperative for a period
100
Total no.of patients operated upon for the period
Anesthesia death rate:
Total number of deaths due to anesthetic agents for a period
100
Total no. of patients administered anesthesia for the period
Maternal death rate (Maternal mortality rate):

Total no.of direct maternal deaths for a period
100
No. of obstetric discharges (incl. deaths) for the period
Neonatal death rate
Total number of newborn deaths for a period
100
No of newborn infant discharges (incl. deaths) for the period
Perinatal mortality rate:
Intermediate (20-28 weeks gestation or 500-1000 gm weight) and late
fetal (after 28 weeks) deaths + neonatal
Deaths (less than 28 days)
100
Births and fetal deaths for the period
Hospital admission rate
Hospital admission rate denotes the number of hospital admissions
per 1000 population per year. Hospital admission rate
Total admissions during the year
100
Midyear population
Per capita hospitalization rate
Per capita hospitalization rate is the per capita days of hospital care given
per 1000 population for a particular geographical area. During a particular
period. It expresses the volume of hospitalizations in terms of number
of hospitalization days per person per year.
Total number of days inpatient care
100
Midyear population
The rang varies from 0.3 to 1.5 in India, it is approximately 0.3.
Bed turnover rate (BTR)
Bed turnover rate gives the number of discharges per hospital bed
over a given period, i.e. how many times a bed was turned over
during the period, say a year. It is directly related to the average
length of stay (ALS) and bed turnover interval (BTI).
No. of discharges for a given period of time
Bed turnover rate:
Average bed count for that period of time
Total patient days during a given period

Average length of stay =
Total discharges (including deaths)
during the same period
Hospital Statistics 355
Average length of stay (ALS)

Average length of stay (ALS) is the average period in hospital (in
days) per patient admitted, i.e. the average number of days of service
rendered to each inpatient
Number of inpatient days care (excluding) healthy newborn during
the year
ALS = Total number of discharges and deaths.
Other Statistics
Autopsy rate
This relates to autopsies carried out on patients who died in hospital
Therefore, it excludes stillbirths. Dead on arrival/brought in dead.
and medicolegal cases.
No of autopsies
Autopsy rate = 100
No of deaths in hospital
Consultation (written only) rate
No. of patients receiving consultations
100
No. of patients discharged (and dead)
Cesarean Section Rate
Total no. of cesarean sections in a period

100
No. of deliveries (incl. cesarean sections) in the period
Infection Rates
Hospital infection rate:
Total no. of nosocomial infections in the hospital
(or specific clinical unit) for a period
100
Total no. of discharges (incl. deaths) in the hospital
(or specific clinical unit) for the period
Postoperative infection rate:
No. of infections in clean surgical cases for a period
100
Number of clean surgical operations for the period
Chapter
28 Biostatistics
CHAPTER OUTLINE
COLLECTION AND PRESENTATION OF DATA
GRAPHICAL REPRESENTATION OF DATA
CENTERING CONSTANTS (MEASURES OF CENTRAL TENDENCY)
MEASURES OF VARIATION
INTERNATIONAL DEATH CERTIFICATECAUSE OF DEATH
INTRODUCTION
Definitions of Statistics
The word statistics used in plural means figures but while used in
singular it implies science of figures such as collection, presentation,
analysis and interpretation of data.
Quantitative Medicine
Since, every thing in medicine be it research, diagnosis, or treatment
depends on measurement and counting the medical biostatistics is
defined as quantitative medicine.
Science of Variation
For defining normal health and prescribing the normal limits for health,
the variations in the characteristics like pulse rate, blood pressure, height,
weight, etc. are noted and studied. In this sense it is defined as science
of variation.
Science of Averages
Many types of averages are computed in course of the analysis of a
statistical data to arrive at an inference or interpretation. In this
connection it is also defined as the science of averages.
Biostatistics in the real sense means Science of figures about any
life.
The three important branches of biostatistics are: (a) Health statistics,
(b) Medical statistics, and (c) Vital statistics.
a. The Health Statistics are collected in connection with the assessment
of health and for prescribing the normal limits of health.
Biostatistics 357
b. The medical statistics deal with the study of injury defect and disease.
The efficiency of various drug. Seraline of treatment are also tested
statistically in this branch.
c. Vital statistics deal with the figures of births deaths and marriages in
populations.
Use of Biostatistics
1. Interpretation of observation
2. Assessment of patient/situation/problem
3. Management of patient/situation/problem
4. Evaluation of patient/situation/problem.
COLLECTION AND PRESENTATION OF DATA

The data collected in respect of any characteristics will be full of figures
and lies in a haphazard manner. It conveys no meaning unless the figures
are sorted out properly and presented systematically.
The following are the principles of presentation:
1. To arrange the data in such a way that it should create interest in the
readers mind at the first sight.
2. To present the information in a compact and concise form without
losing important details.
3. To present the data in a simple form so as to draw the conclusion
directly by viewing at the data.
4. To help in the further statistical analysis.
Presentation of Data (Flow chart 28.1)
Flow chart 28.1: Presentation of data

Frequency Table
It is a table showing the frequency with which the values are distributed
in different groups or classes with some defined characteristic.
Construction of a Frequency Table

Rules: Rules to be followed in the construction of a frequency table.
a. The class interval should not be too large or too small.
b. The number of classes to be framed more than 8 and less than 15.
c. Class interval should be equal and uniform throughout the classification.
d. After the construction of the table, proper and clear heading should
be given to it.
e. The base or source of a data should be mentioned with the pattern of
analysis in a footnote at the end of the table.
f. If some observations are omitted or missing the details of exclusion
of such observations should be mentioned.
GRAPHICAL REPRESENTATION OF DATA

Graphs
1. The data is presented diagramatically.
2. It gives better grasp than the table.
3. Interpretation is done by rough translation of the points into the actual
figures as a change in the scale will give different patterns.
4. Graphs should never be substituted for statistical table because the
graphs cannot have the mathematical treatment whereas table can be
treated mathematically.
5. Whenever comparing graphs note the difference in the scale if any.
Bar Diagram (Fig. 28.1)

It is used for representing discrete or discontinuous data. Data is
presented in form of rectangular bars of equal breadth. Each bar
Fig. 28.1: Bar diagramprevalence of reproductive tract infection

Biostatistics 359
represents one attribute/variate. The width of the bar and the gaps between
the bars should be the same throughout. Scale must from zero if not it
may be indicated by broken bar.
1. Breadth of all bars is equal.
2. Length of each bar is proportional to the frequency of the characteristic
it is representing.
3. Distance between the bars is smaller than the breadth of each bar.
4. Scale has been indicated.
5. Scale starts from zero.
6. Available space is used.
Proportional Bar Diagram (Fig. 28.2)

The bar is colored differently to show various proportions.
Gynecological morbidity
Age Vaginitis Cervicitis Cervical Genital Pelvic Firm bulley
group erosion prolapse inflamma- uterul
years tory disease
No% No% No% No% No% No% No% No% No% No% No% No%
15-25 12 18.2 34 31.7 21 20.6 4 10 11 31.4 02 14.3
26-35 37 56.1 57 53.3 61 59.8 10 25 18 51.4 08 57.1
36-45 16 24.2 11 10.3 18 17.6 20 50 5 14.3 02 14.3
46+ 01 1.5 05 4.7 02 2.0 6 15 01 2.9 02 14.3
Total 66 100 107 100 102 100 40 100 35 100 14 100
Fig. 28.2: Proportional bar diagramage-wise distribution

of gynecological morbidity on clinical examination
Histogram (Fig. 28.3)

1. This method is useful for presenting frequency of quantitative
continuous variate.
2. It is an area diagram composed of a series of adjacent rectangles. The
area of each rectangle is proportional to the frequency of that group
or class.
Fig. 28.3: Histogram with frequency polygon
3. The width of the rectangles is equal.

4. Histogram is useful to represent the mode graphically.
5. The only disadvantage of this graph is that it varies accordingly to
the class intervals.
Frequency Polygon
Frequency polygon is an area diagram of frequency distribution
developed over a histogram.
It is a linear representation of a frequency table and histogram.
Frequency is plotted at the central point of a group. It is used when two
or more frequency distributions are to be compared.
Pie Diagram (Fig. 28.4)

This is used for showing proportions of the total areas of sectors of a
circle each sector represents an attribute/variate. It is used for presenting
qualitative data and quantitative discrete data.
The Ogive
The ogive is graph of the cumulative relative frequency distribution.
This is curve plotted on X- and Y-axis with the corresponding
cumulative frequency of each class or group. This curve is useful to find
the median and the quartiles graphically.
Biostatistics 361
Fig. 28.4: Pie diagramgynecological morbidity on clinical examination
CENTERING CONSTANTS
(MEASURES OF CENTRAL TENDENCY)
Measures of central tendency is measurement of variate which represents
a group of individual measurement in a simple and precise manner.
After collecting and presenting the data in frequency distribution, it
is essential to calculate certain values which may be used as descriptive
characteristic of that distribution. With the help of these values it is
possible to make the comparisons between two series of observations
as they represent the entire data. A majority of the observations are
very close to this value.
There are three measures of central tendency.
There are helpful in measuring closeness of each observation to the
central value and to understand the homogenicity of the information
collected.
a. Mean b. Median c. Mode
Arithmetic Mean
It is the sum of observations divided by the total number of observations
and is noted by x .
By Definition
x fx
i. x = (for unclassified data) ii. x = (for classified data)
n N
The arithmetic mean is used usually when the data is quantitative.
Median
i. Median is the middle most item when the observations are arranged
either in ascending or in descending order of magnitude (for
unclassified data).
N c

ii. Median l 2 i (for classified data)
f
Where l = Lower limit of the median class N= Total frequency
f = Frequency of the median class i = Class interval
c = Cumulative frequency of the class preceeding to the
median class. Median is usually preferred in case if the
data is quantitative type.
Mode
Mode is that value of variate for which the frequency is maximum.
It is calculated if median and mean are known by using the relation.
Mode = 3 (Median) 2 (Mean)
In case of normal distribution, Mean = Median = Mode
Mode is generally used in the field of industrial statistics to control
the quality of the products produced.
MEASURES OF VARIATION
Measures of variation are computed to know the degree of scatteredness
of each value from the central value. The important measures of variation
are larger scatteredness indicate not normal condition while less or no
scatteredness suggest to the normal conditions.
Range
Mean deviation
Standard deviation
Coefficient of variation
Quartile deviation
Inter-quartile range
Percentile.
Range
It is the difference between the maximum and minimum value of the
observation. It quantities the variation in one number. The nature of
variation between the observations is not taken into account.
Range = X X
max min
Biostatistics 363
Mean Deviation (MD)

It is arithmetic average of each observations from the mean neglecting
the sign of the deviation. It measures the absolute distance of each
observation from the central value as an average.
|(X x )|
Mean deviation (MD) = (for unclassified data)
n
f |( X x )|
Or = (for classified data)
N
Standard Deviation (SD)

It is defined as Root-MeansSquare-Deviation.
( x x )2
SD = for n < 30
n1
If the number of observation is less than 30, then the sum of squares
of deviation is divided by (n 1) instead of n. It is the most sensitive
measures of variation lesser SD reveals smaller variation and a bigger
SD suggests the deviation from normal condition.
( x x )2
SD = for large size
n
Coefficient of Variation (CV)

It is a relative measure of dispersion defined as the ratio of SD to the
mean and expressed in percentage.
SD
CV = 100%
Mean
If the CV is small then observations are considered to be more
consistent as it reveals little variation from the normal value higher value
of CV. Suggests uncomfortable situation.
Quartile Deviation (QD)

It is obtained by dividing the range between the lower and upper
Quartiles by 2.
Q3 Q1
QD = ,
2
where Q = lower Quartile and Q = upper Quartile
1 3
Q3 Q1
Coefficient of QD =
Q3 Q1
Percentile
In inter-quartile range, we divide the set of observations into four parts.
If the series is divided into 10 equal parts then each part is called as
decile if it is divided into 100 equal parts, each part is called
percentile.
Tests of Statistical Comparison of Two Groups

Tests of statistical comparison of two groups where the cause effect
relationship is to be established for a certain factor under consideration.
Tests of Statistical Significance (Flow chart 28.2)
Flow chart 28.2: Tests of statistical significance
Chance: Something unexpected

Probability: May be defined as possible chances of occurrence.
With which an event is expected to occur on an average, such as of
giving birth to a boy in the first pregnancy.
Null hypothesis: Assumption is made that external factor plays no
role in the condition under study. Such an assumption is called Null
Hypothesis (Ho). This hypothesis nullifies the claim that the experimental
result is different from or better than the one observed already.
Test of Significance (for Large Size)
Standard Error of Mean

Definition: Standard error (SE) of any statistical value is a measure of
variability that would occur merely by chance in the repeated samples
of the same size drawn from the same population. The standard error
Biostatistics 365
SD
of mean is given by SEx , i.e. the SE varies directly with SD and
n
inversely as square root of the size the sample.
Uses of SE of Mean
1. To find the confidence limits of population mean if the standard
deviation of the sample is known.
2. To tell whether a sample is drawn. From the same population or not.
3. To test the significant difference between two sample means.
4. To calculate the approximate size of a sample in order to have the
desired confidence limits.
5. It measures variation due to chance (or biological factors).
Standard Error of difference between Two Means

Definition: If repeatedly independent random samples are drawn in pairs
from the same population and each time the difference between two means
of each pair is calculated. There will be a series of difference between
means. It is shown mathematically that these differences are also normally
distributed around the population mean. The standard deviation of
difference is called as standard error of difference between two means.
Whenever we want to test the significance of the observed difference
between two given means the standard error is applied directly by making
use of the individual standard deviation. In case the observed difference
is more than 1.96 times the standard error, then it is said to be statistically
significant at 95 percent confidence limits.
Formulae
Let X1 and X2 be the means of the first and the second samples
respectively.
Next the steps involved in the calculation of standard error of
difference between two means are:
i. | X1 X2 |
SD12 SD22 1 1 1 1
ii. SED = = SD2 = SD
n1 n2 n1 n2 n1 n2
| X1 X 2 |
iii.
SED
Note: > 1.96 the difference is significant.
The Ho is rejected (Variation is due to external factors)
< 1.96 the difference is not significant.
The Ho is accepted (Variation is due to chance).

Where Ho is null hypothesis Ho is a tentative statement related to
the population and always stated negatively, e.g. there is no difference
in the birth weight of babies born in two different hospitals.
Or
There is no difference in growth rate of babies belonging to two
different socioeconomic groups.
Test of Significance (for Small Sample Size)
t-Distribution
If we have to test the difference between two sample means of small
size (usually less then 30) the sample standard deviation will not be the
accurate estimate of the population SD. Secondary it has been shown
mathematically that the ratio of difference between two means to their
SD will not be following the normal distribution. But it will follow a
slightly different distribution known as Students t-distribution. The
tests based on this distribution are known as t-tests. There are two
t-tests.
i. t-tests for unpaired data
ii. t-tests for paired data.
Criteria for Applying t-test

1. Random samples
2. Quantitative data
3. Variable normally distributed
4. Sample size less than 30.
t-tests for Unpaired Data

This test is used when two types of observation one on controlled group
and the other on experimental group are available to test the significance
of difference between means of the two groups.
Steps involved in the test: Suppose X and Y are two series of observations.
1. Make the null hypothesis that there is no difference between the two
sample means.
2. Calculate the difference between the two sample means.
3. Calculate combined standard deviation.
(X X ) (Y Y )2
CSD =
n1 n2 2
Biostatistics 367
Standard Error of Difference

Standard error of difference is then calculated as
1 1
SED = CSD
n1 n2
(X Y )
tc =
SED
Note: > t 0.05 for df (n1 + n2 2) the difference is significant
Ho is rejected (Variation is due to external factors)
< t 0.05 for df (n1 + n2 2) the difference is not significant
Ho is accepted (Variation is due to chance for biological variation)
t-tests for Paired Data

The paired t-test is used when paired observations are available. This is
when:
i. Observation are made on the same individual before and after
exposure to some factor (or treatment) under study.
ii. The same sample is tested by two methods.
Before proceeding with the test we first frame the null hypothesis that
there is no real difference between the two sets of observations.
Steps for Paired t-test

1. Calculate the difference in each set of observations ( x y = z).
This will form the new set of observation (z series).
2. Find out the mean of this series (Z).
3. Compute the SEz by the formula.
2
Z
Z
2
SD2
n Z
i . SDz = ii. SE2 = iii. t =
n1 n SE2
Z
t= > t 0.05 for df (n 1) the difference is significant.
SE2
< t 0.05 for df (n 1) the difference is not significant.
Ho is accepted.
Standard Error of Proportion (Large Sample Size)

Whenever the statistical value is of qualitative type it is the customary
to express it in proportion of percentages.
The SE of proportions is computed to know the variation in proportions
of different samples drawn from the same population due to chance it is
given by:
Pq
SEP =
n
p = Sample proportion (expressed in percentage)
q = 1 p (expressed in percentage)
When p is the percentage of individuals belonging to one category
and q is the percentage of the individuals belonging to the other category
and n is the number of individuals in the sample. Since, all sample
proportions p and q follow the normal distribution the confidence limits
can be calculated to find the range for p the population percentage.
As a convention we take 1.96 times. SE as a criteria. If the difference
exceeds 1.96 (SE) the difference is said to be significant statistically.
This rule applies for a large sample size (>30) taken from the same
population. For small sample this does not hold good. Since, the
distribution of proportion follows the normal distribution the CL can
also be computed.
P 1. SEp Contains 68.27 percent of sample proportions
Standard Error of Difference between

Two Proportions (Large Sample)
As we have tested the standard error of difference between two means
in case of quantitative data, we can similarly test the difference between
two proportion in case of qualitative data by using SE of proportions.
The difference between proportions in a pair samples will vary from
pair to pair and from even sample to sample though they are drawn
from the same population or universe.
The object of the test is to determine the size of difference that is
likely to occur by chance in samples of given size and how far it can
deviated by chance. In reasonably large sample the SE of difference
may be taken as the sum of square root of the two individual standard
errors of values in two samples.
Steps for Calculation

1. Compute the difference between proportion |(P P )|
1 2
p1 q1 p2 q2
2. SE( p1 p2 ) =
n1 n2
|P1 P2|
3. Z = SE
( p1 p2 )
Biostatistics 369
Probability of a Larger Value of t (Table 28.1)

Table 28.1: Probability (P)
df 0.10 005 001 0.001
1 6.31 12.71 63.66 636.62
2 2.92 4.30 9.39 31.60
3 2.35 3.18 5.84 12.94
4 2.13 2.78 4.60 8.61
5 2.02 2.57 4.03 6.89
6 1.94 2.47 3.71 5.96
7 1.90 2.37 3.50 5.41
8 1.86 2.31 3.36 5.04
9 1.83 2.26 3.25 4.78
10 1.81 2.23 3.17 4.59
11 1.80 2.20 3.11 4.44
12 1.78 2.18 3.06 4.32
13 1.77 2.16 3.01 4.22
14 1.76 2.15 2.98 4.14
15 1.75 2.13 2.95 4.07
16 1.75 2.12 2.92 4.02
17 1.74 2.11 2.90 3.97
18 1.73 2.10 2.88 3.92
19 1.73 2.09 2.86 3.88
20 1.73 2.09 2.85 3.85
21 1.72 2.08 2.83 3.82
22 1.72 2.07 2.82 3.79
23 1.71 2.07 2.81 3.77
24 1.71 2.06 2.80 3.75
25 1.71 2.06 2.79 3.73
26 1.71 2.06 2.78 3.71
27 1.70 2.05 2.77 3.69
28 1.70 2.05 2.76 3.67
29 1.70 2.05 2.76 3.66
30 1.70 2.04 2.75 3.65
35 1.69 2.03 2.72
40 1.68 2.02 2.71 3.55
45 1.68 2.02 2.69
50 1.68 2.01 2.68
100 1.66 1.98 2.63 3.37
1.64 1.96 2.58 3.29
P = Probability of getting a larger value of t than indicated in the column by mere
chance
df = Degrees of freedom
Note: > 1.96 the difference is significant

Ho is rejected
< 1.96 the difference is not significant
Ho is accepted
If the sample is small, then it follows t-test with prescribed degrees of
freedom.
Normal Distribution
If we take large number of observations of a characteristic and if the
observations are arranged in a frequency distribution with small class
interval, the frequencies will be very small in the beginning and at the
end, while the largest frequency is found to have concentrated
somewhere in the middle class. The frequency curve drawn of such
data will give us a smooth symmetric curve. This curve is normal curve.
This is a curve of great importance in statistics theory as it is the basis of
all statistical tests of significance. It is useful:
1. To estimate the population value based on a small sample.
2. To study whether two samples are drawn from the same population.
3. To know whether two samples values differ significantly or not.
Normal Curve
The normal curve is as shown in Figure 28.5.
Fig. 28.5: Normal curve
Characteristics of the Normal Curve

The normal curve has the following characteristicsit is bell shaped
curve.
1. The mean, median and the mode all coincide.
2. It is smooth symmetrical curve. The smoothness is due to small and
equal class intervals. Symmetry means that the curve has one peak
and its skewness is zero.
3. The whole area under the curve is unity.
4. By knowing the sample mean and standard deviation we can calculate
Biostatistics 371
Table of the Unit Normal Distribution (Table 28.2)
Table 28.2: The normal distribution with mean zero and

standard deviation unity
The normal Proportion of Normal variate Proportion of
variate with individuals who with mean = 0 individuals who do
and standard do not exceed not exceed the
deviation unity the value (Z) value (Z)
1 2 3 4
0.0 0.50000 2.3 0.98928
0.1 0.53983 2.4 0.99180
0.2 0.57926 2.5 0.99379
0.3 0.61791 2.6 0.99534
0.4 0.65542 2.7 0.99653
0.5 0.69146 2.8 0.99744
0.6 0.72575 2.9 0.99813
0.7 0.75804 . .
0.8 0.78814 3.0 0.99865
0.9 0.81594 3.1 0.99903
. . 3.2 0.99931
1.0 0.81434 3.3 0.99952
1.1 0.86433 3.4 0.99966
1.2 0.88493 3.5 0.99977
1.3 0.90320 3.6 0.99984
1.4 0.91924 3.7 0.99989
1.5 0.93319 3.8 0.99993
1.6 0.64520 3.9 0.99995
1.7 0.95543 . .
1.8 0.96407 4.0 0.99997
1.9 0.97128 4.1 0.99998
. . 4.2 0.99999
2.0 0.97725 4.3 0.99999
2.1 0.99214 4.4 0.99999
2.2 0.98610 . .
the number of observations falling on both sides of mean at any

multiple of SD by the help of this curve.
a. X 1 contains 68.27 (68.3) percent of observations
b. X 2 contains 95.45 (95.4) percent of observations
c. X 3 contains 99.73 (99.7) percent of observations
We thus find that the values that differ from the mean by more than
twice the SD(s) are fairly large (5%) and that differ more than three
times the SD(s) are very few (0.27) in normal distribution.
If mean height X is 160 cms, SD () = 4 cms and height X is 166 cms. Z
XX 166 160
will be = 1.5 corresponding Z1.5 we find 0.93 out of
4
one 93 percent height do not exceed 160 cms only seven percent of the
subjects will be taller. To find proportion for negative values of Z subtract
the corresponding proportion from one.
Chi-square Test ( 2-Test)

Chi-square ( ): Test offers an alternate method of testing the
significance of difference between two proportions. It can also be used
when more than two groups are to compared.
It was developed by Karl Pearson and has got the following three
common but very important application in medical statistics as test of:
1. Proportion
2. Association
3. Goodness of fit.
The test is usefull to know whether the observed frequencies in the
distribution differ significantly from the expected frequencies calculated
according to same assumed hypothesis like the other tests of significance
it only shows the probability of chance operation.
2
a. Chi-square-test ( -test) is done with the actual observations.
Table of Chi-square (Table 28.3)

Table 28.3: Probability (P)
d.f. .50 .10 .05 .02 .01 005 .001
1 0.45 2.71 3.84 5.41 66.3 7.88 10.83
2 1.39 4.61 5.99 7.82 9.21 10.60 13.82
3 2.37 6.25 7.82 9.84 11.34 12.84 16.27
4 3.35 7.78 9.46 11.67 13.38 14.86 18.47
5 4.35 9.24 11.07 13.39 16.09 16.75 20.52
6 4.35 10.64 12.59 5.03 16.81 18.55 22.46
7 6.35 12.02 14.07 16.62 18.48 20.28 24.32
8 7.31 13.36 15.51 18.17 20.09 21.96 26.13
9 8.34 14.68 16.92 19.68 21.67 23.59 27.88
10 9.34 15.99 18.31 21.16 23.21 25.19 29.59
11 10.34 17.28 19.68 22.62 24.72 26.70 31.26
12 11.34 18.55 21.03 21.05 26.22 28.30 31.91
chi-square
P = Probability of getting a larger value of 2 by chance alone
df = Degrees of freedom
b. Degrees of freedom (df) are not related to the actual number of

observations but on the number of columns and rows in the table, i.e.
d.f = ( c 1) (r 1), c for columns, and r for rows
c. Yates correction is to be applied to the 2 2 contingency tables if any
of the frequency in the cells is less than 5.
Biostatistics 373
d. If the expected frequency in any group is less than five, it is to be

clubed with the frequency of the previous group so that the total
frequency is greater than five.
Formula
1. x =
2

(O E)2
E
where O = observed frequency and E = expected frequency
2. x =
2
( ab bc )2 N
( a b ) (c d ) ( a c ) (b d )
,
where N = a + b + c + d and r = row c = columns

2
| ab bc| N N

2
Yates correction x =

2
( a b ) (c d ) ( a c ) (b d )
2
x = (|O E| 0.5)2
E
Reject Ho if xc2 > x2 0.05 for df = (c 1) (r 1)
Accept Ho if xc2 < x2 0.05 for df = (c 1) (r 1)
Fallacies in Biostatistics
1. Comparison of dissimilar groups.
2. Use of different standard for classification.
3. Generalization from not representative sample.
4. Conclusions based on biased sample.
5. Conclusions from the relative values or proportion rates without
considering absolute values or population.
6. Mixture of noncomparable records.
7. Consideration of association direct or indirect as the cause and effect.
8. Conclusion based on statistical significance alone without other
important practical consideration.
Causes
1. Personal error
Interviewee
Interviewer
2. Institutional errors
Records
Selection of the facts for reporting

3. Spurious correlation
4. Correlation of unusual situations.
Vital Statistics
Definition
Data which gives quantitative information on vital events occurring in
life, i.e. births, deaths, marriages, etc.
Measures of Population
Mid-year population
Arithmetical progression method
Pt = Po + rt
where t is the period in years after the last census.
Pt = Population at the required time, i.e. t years after the last census.
Po = Population of last census
r = Annual increase rate.
Geometrical Progression Method

Pt = Po (1 + r)t where Po = Population of any census years and r =
Annual increase per person in intercensal years. Pt = Population after t
years
Measures of Vital Statistics
Measures of Fertility
1. Crude birth rate (CBR)
Number of live births which occurred among the population
of a given geographical area during a given year
= 1000
Mid-year population of the same geographical area
during same year
2. General fertility rate (GFR)
Number of live births in one year
= 1000
Number of women aged 15-49 years
3. Age specific fertility rate (ASFR)

Number of live births to mothers of a specified age group
= 1000
Mid-year female population of the same age group
Biostatistics 375
4. Gross reproduction rate (GRR)

Total number of female children
born to women in the cohort sample
=
Total number of women in the same cohort sample
5. Net reproduction rate (NRR)
Number of girls survived after the mortality experience
=
Number of cohort women survived at the end of
reproductive period as per their mortality experience
6. Sex ratio at birth
Number of female live births
= 1000
Number of male live birth
Measures of Mortality
1. Crude death rate (CDR)
Number of death which occurred among the population

of a given geographical area during a given year
= 1000
Mid-year population of the same geographical area
during same year
D
CDR = 1000, where D = Total death and P = Total population
P
2. Age specific death rate (ASDR)
Number of deaths in the specified age group

= 1000
Mid-year population of the same age group
3. Infant mortality rate (IMR)
Number of deaths under one year of age

= 1000
Number of live births
4. Still or late fetal death rate
Fetal deaths of after 28 weeks of gestation

= 1000
Live births + still births
5. Perinatal mortality rate (PMR)
Late fetal deaths (after 28 weeks or more)+ deaths under 1 week

= 1000
Live births + still births
6. Neonatal mortality rate (NMR)
Number of deaths up to 28 days of life

= 1000
Number of live births
7. Post-neonatal mortality or late infant mortality rate
Deaths after 28 days of life up to one year

= 1000
Live births
8. Cause specific mortality rate (CSMR)
Number of deaths in a year due to some cause

= 100000
Mid-year population
9. Case fatality rate (CFR)
Number of deaths due to a particular disease

= 100
Number of cases of the same disease
10. Proportional mortality rate (PMR)
Number of deaths from the specific disease in a year

= 100
Total deaths from all causes in that year
Morbidity Statistics
1. Incidence rate (IR)
Number of persons becoming sick in a specified period of time

= 1000
Number of exposed to risk at the same period
2. Period prevalence rate (PPR)
Number of person sick (Old + New) within a specific of time

= 1000
Number exposed to risk at the same period
Biostatistics 377
3. Point prevalence rate (PPR)
Number of person sick (Old + New) at a specified point of time

= 1000
Number of exposed to risk at the point of time
4. Average duration of sickness
Point prevalence rate

=
Incidence rate
INTERNATIONAL DEATH CERTIFICATE

CAUSE OF DEATH (TABLE 28.4)
Table 28.4: International death certificatecause of death
Name of patients: Approximate interval

between onset and death
Address:
Part 1
Disease or condition directly leading to death (a)
Antecedent cause: Morbid condition if any:
Giving rise to the above (b)
Cause stating the underlying condition last (c)
Part 2
Other significant condition contributing to the death
but not related to the death or condition causing
it.
Signature
BIBLIOGRAPHY
1. Kulkarni AP, Baride JP. Textbook of community medicine, 2nd edn, 2002.
2. Mahajan BK. Methods in Biostatics, 6th edn, 1997.
3. Parks Textbook of PSM, 16th edn, 2000.
Chapter
29 Problems
CHAPTER OUTLINE
ENVIRONMENTAL PROBLEMS BIOSTATISTICS
CORRELATION AND REGRESSION DEMOGRAPHY
EPIDEMIOLOGICAL AND NUTRITIONAL EXERCISES
ENVIRONMENTAL PROBLEMS
1. 1 cubic feet = 6.25 gallons of water
2. 1 cubic meter = 1000 liters of water .
3. 1 gallon of water = 4.55 liters.
4. If blue color appears in I, II, and III up of Horrocks apparatus the
required amount of bleaching powder to disinfect the well is 2,4,
6 gm for 100 gallons of water.
5. Standard bleaching powder contains 33 percent of available chlorine.
6. If available chlorine is 25 percent, i.e. for 1 gm, it is taken as
inverse proportion and while calculating, multiply 1000 liter of water
54. This will give you required amount of bleaching powder to
disinfect 1000 liters of water. If available chlorine in given sample of
1
water is 20 percent in of 1 gram multiply by 2.
5
7. If the well is circular and measurement is in feet, calculate the total
2
amount of water by using the formula 5D h.
Where D = diameter of well , h = depth of water
8. If the measurements are in meters, then:
2 22 2 2
r h or r h or 3.14 r h
7
where r = radius of well, h = depth of water
9. If the well is rectangular well then:
L b h 6.25 which gives, gallons of water.
10. If measurements are in meters, then:
L b h 1000 gives liters of water.
Problems
1. Calculate the amount of bleaching powder required to disinfect a circular
well having a diameter of 6 m and depth of water is 12 m. The Horrocks test
shows blue color in 4th cup.
Problems 379
Sol. Given D = 6 m, R = 3 m, H = 12 m
The given data for circular well is in meters, so
2
= 3.14 r h
= 3.14 32 12
= 3.14 9 12
= 3.14 108
= 339.12 m
1 cubic meter = 1000 liters of water
339.12 meter = ?
339.12 1000 = 339120 liters of water
4.55 liters = 1 gallon of water
339.120 liter = ?
339120/4.55 = 74531.868 gallons
100 gallons = 8 gm of bleaching powder
74531.868 = ?
74531.868 8/ 100 = 5962.5 gm
2. Calculate the amount of bleaching powder required to disinfect a circular
well where D = 5 feet and depth of water is 10 feet. Available chlorine is 33
percent in bleaching powder.
Sol. Given D = 5 feet and h = 10 feet
The given data for circular well is in feet, so
5 D2 h = 5 5 2 10
= 5 25 10 = 1250 feet
1 cubic feet = 6.25 gallons of water
1250 feet = ?
1250 6.25 = 7812.5 gallons of water.
1 gallon of water = 4.55 liters
7812.5 gallons of water = ?
7812.5 4.55 = 35546.87 liters
1000 liters 2.5 gm of bleaching powder
35546.85 liters = ?
35546.85 2.5/1000 = 88867.18/1000
= 88.867 gm of bleaching powder.
3. A well measuring 10 m in diameter having depth of water 20 m. Available
chlorine is 25 percent in bleaching powder. Calculate the amount of bleaching
powder required.
Sol. Given D = 10 m, H = 20 m, R = 5 m
The given data for circular well is in meters, so
= 3.14 r2 h
= 3.14 52 20
= 3.14 25 20
= 3.14 500
= 1570 m
Available chlorine is 25 percent, i.e. of gm = 0.25 gm
Hence,
= 1570 0.25 4
= 1570 1 = 1570 gm
= 1.57 kg.
4. Calculate the amount of bleaching powder required if L = 6 feet, B= 8 feet,
D = 25 feet Horrocks apparatus shows blue color in 12th cup.
Sol. The given data for rectangular well is in feet, so
= L b h 6.25
= 6 8 25 6.25
= 48 156.25
= 7500 gallons of water
100 gallons = 24 gm of bleaching powder, then:
7500 gallons = ?
7500 24 = 1800 gm
= 1.8 kg
5. An annual fair has been organized in summer season in a village on the bank
of river. What arrangements you shall make for the safe drinking water for
the fair?
Sol. The survey should be done by Medical Officer (MO). The fair
consists of a large number of people.
Gathered at one place it is the site for the spread of many diseases.
Arrangements:
The site should be surveyed by Medical Officer.
As the fair is to be conducted on the bank of rivers, all the
precautions should be taken to prevent contamination of water.
Fencing of river should be done, to prevent people going in for
wash.
Safe drinking water should be provided by constructing
reserviours tanks separately away from the gathering place,
which should be provided with taps to prevent contamination.
The surrounding should be kept clean or platform should be
constructed so that there is no stagnation of water.
Water should be changed regularly one for two days.
Health education to the people regarding water-borne disease.
6. There is an NCC camp of 100 students in the outskirts of the city. What
type of sanitary measures you suggest?
Sol. Arrangements:
The site should be surveyed by Medical Officer.
It should be selected in such a way that it should be clean, free
from endemic diseases.
Problems 381
It should be free from mosquito and fly-breeding sites.

Trench latrine should be provided for some days, shallow
latrines, for weeks and for months deep trench latrine.
Disposal of refuse should be done by controlled tipping.
Safe water should be provided by boiling and cooling the water
and chlorine tablets.
All the students should be advised to have separate beds, towels,
to prevent communicable diseases.
BIOSTATISTICS
1. Following are the respiratory rates of 10 infants suspected to be suffering
from acute respiratory infection.
53, 52, 55, 48, 54, 59, 46, 58, 49 and 60.
Find the measures of central tendency.
Sol.
n
x
i 1
i
534
i. Mean = = = 53.4
n 10
n 1
th
ii. Median = value in the arranged series.

2
Arranging the data in ascending order:
46, 48, 49, 52, 53, 54, 55, 58, 59, 60
10 1
th
= value
2
th
11
= value = 5.5th
2
i.e. Average of 5th and 6th value
53 54
= = 53.5.
2
iii. Mode: Mode does not exist.
Mode is most repeated value or the value which possesses the
highest frequency. Here, in this problem not any value repeats,
i.e. it indicates mode does not exist in this distribution.
2. During the MCH clinic at Devarayasamudra RHTC, the Hb% of 10 ANC
and 10 PNC women were recorded as follows:
ANC (gm%) : 12, 11, 10, 12, 12, 11, 08, 06, 09, 08
PNC (gm%) : 11, 09, 10, 11, 10, 11, 07, 08, 05, 07
Calculate the measures of dispersion and compare the coefficient of variation.
Sol. i. Take ANC group. Write the data in ascending order:

6, 08, 08, 09, 10, 11, 11, 12, 12, 12
Range = H L
= 12 6
=6
n
|(x
i 1
i x )|
Mean deviation =
n
(from Mean)
17.2
= = 1.72
10
X x |(xi x )| (xi x )2
12 2.1 4.41
11 1.1 1.21
10 0.1 0.01
12 2.1 4.41
12 9.9 2.1 4.41
11 1.1 1.21
08 1.9 3.61
06 3.9 15.21
09 0.9 0.81
08 1.9 3.61
17.20 38.90
(for n < 30)
n
(x i x )2
Standard deviation = i 1
n1
38.9
=
9
= 4.3222
SD = 2.0790 =

Coefficient of variation = 100
x
n

x i
99
where mean ( x ) i 1
9.9
n 10

2.0790
CV = 100 = 0.2100 100
9.9
CV for ANC group = 21
Problems 383
ii. Take PNC group:

Write the data in ascending order:
05, 07, 07, 08, 09, 10, 10, 11, 11,11
Range = 11 05 = 6
Range = 6
n
|x i x|
Mean deviation = i 1
n
x1 x |(xi1 x )| (xi1 x )2
11 2.1 4.41
09 0.1 0.01
10 1.1 1.21
11 2.1 4.41
10 8.9 1.1 1.21
11 2.1 4.41
07 1.9 3.61
08 0.9 0.81
05 3.9 15.21
07 1.9 3.69
17.2 38.9
n

xi
89
Mean i 1 8.9
n 10

n
x
i 1
i x
Mean deviation =
n
17.2
= = 1.72
10
n
(x i x )2
Standard deviation = i 1
n1
38.9
=
9
= 4.3222
SD = 2.0790
2.0790
CV = 100 = 100
x 8.9
= 0.2336 100
= 23.36
CV of ANC group is less than CV of PNC group
3. The following data represents the total weight gain in kg of 15 women at the
end of 9th month of pregnancy:
06, 08, 07, 10, 06, 07, 07, 08, 09, 11, 10, 10, 12, 14, 12.
Calculate the measures of central tendency and discuss the limitations of
the mean.
n
x i
137
Sol. i. Mean = x = i 1
= 9.1333
n 15
ii. Median is the middle most value in the arranged series:
06, 06, 07, 07, 07, 08, 08, 09, 10, 10, 10, 11, 12, 12, 14.
n 1
th
Median = value
2
15 1
th
= value
2
th
16
= value = 8th value
2
Median = 9
iii. Mode = Most repeated value
In this problem 07 and 10 repeat three times. Therefore, this is
a
Bimodeldistribution. Both 7 and 10 are the modes.
Limitations of the Mean

It is unduly influenced by an abnormal value in the distribution.
It cannot be easily calculated in the case of distributions containing
open-end class-interval.
If one of value of the items is missing, the arithmetic mean cannot be
calculated.
Sometimes it gives fallacious conclusions.
It has an upward bias. It gives less importance to smaller items and
more importance to larger items in the data, i.e. a large item in the
series can push-up the value of arithmetic mean considerably, but a
small item cannot pull down the value of it to the same extent.
Problems 385
4. In a series of boys during admission to a college the mean height was 160 cm
and the standard deviation was 10 cm. In the same series, the mean weight
was 55 kg and the standard deviation was 5 kg. Find which of the above two
characters show greater variation.

Sol. CV of 1st character = 100
x
10
CV = 100
160
and CV = 6.25%

CV of IInd character = 100
x
5
CV = 100
55
CV = 9.09%
Thus, we find that the 2nd character shows greater variation.
5. The systolic BP of male and female interns posted to UHC, Gulpet, is as
follows:
Males : 130, 120, 126, 128, 122, 142, 116 and 160
Females : 110, 120, 100, 114, 108, 102, 110 and 110
Calculate arithmetic mean and standard deviation.
Comment on the above data.
Sol. For males:
X1 x |(xi x )| (xi x )2
130 0.5 0.25
120 10.5 110.25
126 4.5 20.25
128 2.5 6.25
122 130.5 8.5 72.25
142 11.5 132.25
116 14.5 210.25
160 29.5 870.25
1044 1422
Arithmetic mean for males = x
1044
x= = 13.05.
8
n
(x
i 1
i x )2
Standard deviation =
n1
1422 1422
= =
8 1 7
SD = 203.1428
SD = 14.25
For females:
x1 x |(xi x )| (xi x )2
110 0.75 0.56
120 10.75 115.56
100 9.25 85.56
114 4.75 22.56
108 109.25 1.25 1.56
102 7.25 52.56
110 0.75 0.56
110 0.75 0.56
874 279.48
n
x i
874
Arithmetic mean for females = i 1
= 109.25
n 8
(x
i 1
i x )2
n1
279.48 279.48
=
8 1 7
SD = 39.9257
SD = 6.3186
Comments: On comparing the SD values for males and females, it is
concluded that:
(SD value for male = 14.25 and
SD value for female = 6.31)
The deviation of values from mean in the male is greater than the
female values.
6. The respiratory rate in 10 persons was as follows:
20, 21, 22, 16, 19, 18, 19, 17, 20 and 18.
Calculate the range, mean deviation, standard deviation and coefficient of
variation.
Sol. Range = H L = 22 16
Range = 4
Problems 387
xi x (xi x ) (xi x )2
20 1 1
21 2 4
22 3 9
16 3 9
19 0 0
18 19 1 1
19 0 0
17 2 4
20 1 1
18 1 1
190 14 30
n
|(x
i 1
i x )|
14
Mean deviation = = = 1.4
n 10
(x
i 1
i x )2
n1
30
=
9
SD = 3.3333
SD = 1.8257

CV = 100
x
1.82
= 100
19
= 0.0957 100
CV = 9.57
CORRELATION AND REGRESSION

1. Here the variables are non-correlated. Because the points spread all
over the graph.
2. The variables are positively correlated. Because the points cluster

around a line with positive slope. (It is also called partially positive
correlation)
(Moderately + ve correlation)
3. The variables are positively and perfectly correlated. Because the

points form a line with positive slope.
4. There is a curvilinear relation between the variables.
5. The variables are negatively very correlated. Because the points

cluster around a line with negative slope (It is also called partially
negative correlation)
(Moderately ve correlation)
6. This diagram indicates curvilinear relation between the variables.

Problems 389
7. The variables are perfect ve correlation. Because the points form a

line with ve slope
8. The variables are perfectly vely correlated.
Problems
1. Find the value r for the following data:
X48, 52, 60, 45, 65, 72, 80, 50
Y50, 55, 72, 50, 60, 60, 78, 55.
Sol. Karl Pearsons coefficient of correlation between two variables
X and Y is:
Covariance (x , y) Cov (x , y)
rxy =
var (x) var (y) x y
( x x )( y y )
rxy =
( x x )2 ( y y ) 2
X Y (x x ) (y y ) (x x ) (y y ) (xi x )2 (y y )2
48 50 11 10 110 121 100
52 55 7 5 35 49 25
60 72 1 12 12 1 44
45 50 14 10 140 196 100
65 60 6 0 0 36 0
72 60 13 0 0 169 0
80 78 21 18 378 441 324
50 55 9 5 45 81 25
720 1094 718

(x x )( y y )
rxy =
(x x )2 ( y y )2
[ ]
When means are not known, we can use:
n xy x y
r= nx 2 x 2
n y 2 y 2

x
i1
i
472
x = = 59 and
n 8
n
y
j1
i
480
y = = 60.
8 8
From the table,
720 720
=
1094 718 785492
720
= = 0.8123 = 0.8 = rxy = 0.8
886.2815
i.e. the variables are +vely correlated.
2. Find the regression coefficients for:
X : 10, 15, 16, 20, 21, 17, 12, 13, 18 and 8
Y : 7, 16, 20, 18, 19, 21, 10, 14, 19, 6
Sol. The regression coefficients are:
( x x )( y y )
bxy =
( x x )2
( x x )( y y )
and byx = if means are known.
( y y )2
[ ]
If the means are not known, then we can use
r x n xy x y
bxy =
y n y 2 y 2
r y n xy (x)(y)
and byx =
x n x 2 (x 2 )
Problems 391
Applying the first formulae for bxy and byx
x y (x x ) (y y ) (x x ) (y y ) (xi x )2 (y y )2
10 7 5 8 40 25 64
15 16 0 1 0 0 1
16 20 1 5 5 1 25
20 18 5 3 15 25 09
21 19 6 4 24 36 16
17 21 2 6 12 4 36
12 10 3 5 15 9 25
13 14 2 1 2 4 1
18 19 3 4 12 9 16
8 6 7 9 63 49 81
Total=150 150 188 162 274
x 150
x = = 15
n 10
y 150
y = = 15
n 10
( x x )( y y ) 188
bxy = =
(x x ) 2
162
bxy = 1.16
( x x )( y y ) 188
byx = =
(y y) 2
274
byx = 0.6861
3. For the following data calculate correlation coefficient to determine
association if any between fluoride content of drinking water and community
fluorosis index:
Drinking water fluoride level mg/L Community fluorosis index
0.8 0.1
1.3 0.4
1.5 0.9
1.9 0.6
2.3 0.7
2.4 1.1
2.6 0.8
3.5 1.1
Sol. Karl Pearsons correlation coefficient r

Cov ( x , y) Cov ( x , y)
rxy =
var ( x) var ( y) x y
(x x ) ( y y )
rxy =
(x x )2 ( y y )2
X y (x x ) (y y ) (x x ) (y y ) (x x )2 (y y )2
1.8 0.1 0.36 0.6 0.216 0.1296 0.36
1.3 0.4 0.86 0.3 0.258 0.7396 0.09
1.5 0.8 0.66 0.1 0.066 0.4356 0.01
1.9 0.6 0.26 0.1 + 0.026 0.0676 0.01
2.3 0.7 0.14 0 0.000 0.0196 0
2.4 1.1 0.24 0.4 0.096 0.0576 0.16
2.6 0.8 0.44 0.1 0.044 0.1936 0.01
3.5 1.1 1.34 0.4 0.536 1.7956 0.16
Total: 17.3 5.6 1.11 3.4388 0.8
xi
17.3
x =
= 2.16
n 8
yi 5.6
y = = 0.7
n 8
rxy =
(x x ) ( y y )
(x x )2 ( y y )2
1.11 1.11 1.11
=
3.4388 0.8 2.7510 1.65
1.11
rxy = = 0.6692 rxy = 0.7.
1.6586
This indicates there is +ve correlation between these two variables.
DEMOGRAPHY
1. The census population of Kolar town.
1981 : 75,000
1982 : 87,000
No. of live births in 1988 : 1250
Total no. of deaths in 1988 : 750
No. of infant deaths : 70
Deaths of infants within 1 month of births : 30
a. Calculate all vital statistics rates for 1988
b. Compare with current national rates and comment.
Problems 393
Sol. a. For the calculation of 1988 vital rates,

CBR = (Total births/Mid year population of 1988) 1000
Mid year population (MYP) of 1988
Pt = P + rt
MYP of 1988 = 75000 + rt
Increase in 10 years
= 87000 75000
= 12000
Average increase per year = 12000/10 = 1200
MYP of 1988 = 75000 + (1200 7) + (1200 1/3)
= 75000 + 8400 + 400
= 83800
b. i. CBR = (Total births/Mid year population of 1988 ) 1000
= (1250/83800 ) 1000
= 0.0149 1000
CBR = 14.9
ii. CDR = (No. of deaths registered during a year in an area/Mid
year population of 1988) 1000
= (750/83800 ) 1000
= 8.9498
iii. IMR = (Number of deaths under one year of age or infants/
No. of live births ) 1000
= (70/1250 ) 1000
IMR = 7000/125 = 56
iv. NMR = Neonatal mortality rate
= (No. of deaths up to 28 days of life/
No. of live births) 1000
NMR = (30/1250) 1000 = 3000/125 = 24
2. The following vital events are recorded in Kolar district for 1991:
MYP of 1991 : 22,00000
Total no. of deaths in 1991 : 20,000
Total no. of live birth in 1991 : 40,000
Newly diagnosed TB cases : 220
Old cases of TB : 880
No. of deaths due to TB : 140
Calculate all vital indices for 1991 [comment on the growth rate of the
district with reference to the current year].
Sol. CBR = (No. of live births/Mid year population of 1991) 1000
= ( 40000/2200000 ) 1000
= 18.1818
CDR = (No. of deaths/MYP of 1991) 1000
= (20000/2200000 ) 1000
CDR = 200/22 = 9.0909
3. The following is the data of DSRM. PHC area for 1997:

Midyear popn : 70000
Total deaths : 1050
Total birth : 2500
Total infant deaths : 300
No. of maternal deaths : 15
No. of death with in 28 days : 120
Calculate all vital rates of the PHC area for 1997. Compare with the goal for
2000 AD.
Sol. i. CBR = (No. of live births/Mid year population of 1997) 1000
= (2500/70000) 1000
CBR = 250/7 = 35.742
ii. CDR = (Total no. of deaths/MYP of 1997) 1000
= (1050/70000) 1000
CDR = 105/7 = 15
iii. Infant mortality rate
= (Total infant deaths/No of live births) 1000
IMR = (300/2500) 1000
= 3000/25
IMR = 120
iv. Maternal mortality rate
MMR = (No. of maternal deaths/Total of live births) 1000
= (15/2500) 1000
= 150/25 = 6
MMR = 6
v. Neonatal mortality rate
= (No. of deaths with 28 days of life
No. of live births) 1000
NMR = (120/2500) 1000
= 1200/25
= 48
4. The MYP of Kolar town in 1998 was 90,000 and the following vital indices
were reported:
CBR = 24/1000 MYP
CDR = 10/1000 MYP
IMR = 80/1000 LB
MMR = 3/1000 LB
Calculate :
i. No. of births
ii. No. of deaths
iii. Infant deaths
iv. Maternal deaths
v. Growth rate for 1998.
Problems 395
Sol. i. CBR = (No. of births/MYP of Kolar) 1000

No. of births = (CBR MYP)/1000
= (24 90,000)/1000 = 2160
No. of births = 2160
Similarly
ii. No. of deaths = (CDR MYP)/1000
= (10 90,000)/1000
No. of deaths = 900
iii. IMR = (No. of infant deaths/Total no. of live births) 1000
No. of infant deaths = (80 2160)/1000
= 1728/10 =172.8
Infant deaths = 172.8
iv. MMR = (No. of maternal deaths/No. of live births) 1000
Maternal deaths = (3 2160)/1000
= 6480/1000 = 6.48
Maternal deaths = 6.48
v. Growth rate for 1998 = Birth rate Death rate
= 24 10
GR = 14/1000 MYP
5. The MYP of PHU is 35,000. The age wise population of women and live
births is given below :
Age group No. of women No. of live births
15-25 3500 300
25-35 5500 600
35-45 3000 200
Total 12000 1100
Calculate
i . CBR
ii. Age specific fertility rate
iii. Total fertility rate
iv. Comment on the results.
Sol. i. CBR = (Total births/Mid year population) 1000
= (1100/35000) 1000
CBR = 31.4285
ii. Age specific fertility rate
In the first group, i.e. for 15 to 25 age group
ASFR = (No. of live births reported at 15-25 age group/
No. of mothers at the same age group) 1000
ASFR = (300/3500) 1000
= 3000/35
= 85.71
ASFR for the age-group 25 to 35 i.e.

ASFR = (600/5500) 1000
= 6000/55 =109.0909
= 109.1
and ASFR for the age group 35 to 45
ASFR = (200/3000) 1000
ASFR = 2000/30 = 66.66
iii. Total
Fertility rate = Addition of the ASFR gives us TFR
TFR = 85.71 + 109.1 + 66.66
= 261.47
6. The following is the data related to Mulbagal town for 1996:
MYP : 64000
No. of live births : 1856
No. of deaths : 704
No. of fetal deaths > 1000 gms : 40
No. of deaths age < 1 week : 20
No. of deaths aged < 4 weeks : 120
No. of infant deaths : 160
No. of maternal deaths between 28 weeks of
pregnancy and 42nd day of delivery : 8
Calculate CDR, CBR, MMR, perinatal mortality rate, NMR, IMR, GR.
Sol. i. CDR = (No. of deaths registered during a year in an area/
Mid year population) 1000
= (704/64000) 1000
CDR = 11
ii. CBR = (No. of live births/Mid year population) 1000
1856
= 1000 = 0.029 1000 = 29
64000
iii. MMR = (No. of female deaths registered during a year due
to pregnancy and its complication/No. of live births
during that year) 1000
MMR = (8/1856) 1000
MMR = 4.3103
iv. Perinatal mortality rate
= PMR = [Late fetal deaths (after 28 weeks or more) +
deaths under one week/Total births (live + still)]
1000
= [(40 + 20)/1856] 1000
= (60/1856) 1000
= 60000/1856
PMR = 32.32
Problems 397
v. NMR = Neonatal mortality rate

= (Number of deaths upto 28 days of life/
Number of live births) 1000
= (120/1856) 1000
= 0.0646 1000 = 64.6
vi. IMR (Infant mortality rate)
IMR = (Number of deaths under one year of age/
Number of live births) 1000
= (160/1856 ) 1000
= 0.0862 1000
IMR = 86.2
7. The census population of a district in 1981 and 1991 was 20,00,000
and 26,00,000 respectively calculate:
Mid Year population of 1989
What is the present growth rate of India
Sol:
Using arithmetical progression method
Population of a district in 1981 = 20,00,000
Population of a district in 1991 = 26,00,000
Increase in 10 years = 26,00,000 20,00,000 = 600,000
Average increase per year = 60,000
Mid year population in 1989 = Pt = Po+rt (from AP)
= 20,00,000 + 60000 8 + 60000 1/3
(1/3 Means 1st March to June 30th)
= 20,00,000 + 480,000 + 20,000
= 25,00,000
8. In an estimated MYP of 100,000 there were 1500 live births and 850 deaths
in 1995.
No. of abortions reported : 300
No. of fetal deaths (1000 gm) : 50
Deaths 0-7 days : 50
Deaths 8 day to 1 month : 25
Deaths 1 month to 1 year : 50
Woman in the child bearing age group constituted 20 percent of the
population 400 deaths occurred in the age group of 45 years and
above. These were:
Heart disease : 200
Chronic lung disease : 50
Neoplasms : 80
Suicides : 20
Others : 50
Calculate
a. General fertility rate
b. IMR
c. PMR
d. Proportional mortality of deaths overs 45 years due to heart disease.
Sol. a. General fertility rate :
GFR = (No. of live births in one year/ No. of women aged
15-49 years ) 1000
GFR = (1500/20000) 1000 = 75
( 20% of the population are women in the child bearing age
group).
b. IMR = (Number of deaths under one year of age/No. of live
births) 1000
IMR = (50 + 25 + 50/1500) 1000
= (125/1500) 1000
= 0.0833 1000
IMR = 83.3
c. PMR = (Late fetal deaths (after 28 weeks or more) + deaths
under one week/Total births) 1000
= (50 + 50/1500) 1000
PMR = (100/1500) 1000 = 66.66
d. Proportional mortality of deaths over 45 years due to heart
disease. Proportional mortality rate
= (No. of deaths due to specific cause/Total deaths)
100
PMR = (200/400) 100
(Deaths, due to heart disease = 200)
PMR = 50%
9. Estimate the midyear population in the year 1985 given 1971 census
population 548.1 million and 1981 census population 685.2 million.
Sol. Population in the year 1981 = 685.2 million
Population in year 1971 = 548.1 million
Population growth in 10 years = 137.1 million
Annual rate of growth = (Pt P0)/P0 1/10
= (137.1/548.1) 1/10
= 0.025
It is assumed that r remains contant approximately.
Then by geometric growth model
Pt = P0 (1 + r)t
Log Pt = LogP0 + tlog (1+ r)
= log 685.2 + (4 + 1/3) log (1 + 2.5/100)
= log 685.2 + 13/3 log 1.025
= 2.8358 + 4.33 0.0107
Problems 399
= 2.8358 + 0.0463
logPt = 2.8821
Pt = Antilog (2.8821)
= 762.3 million.
EPIDEMIOLOGICAL AND NUTRITIONAL EXERCISES

1. In a boarding house inhabited by 100 children all below 10 years, on 1/3/88,
10 cases of measles occurred. On the 11th a second batch of 35 cases were
detected. Interrogation of those who had not contracted the disease revealed
that 15 of them were previously immunized against measles. Determine the
serial interval and the secondary attack rate of measles.
Sol. Serial interval
= Gap between the onset of primary and secondary case.
= Gap between 1st and 11th March = 10 days.
Secondary attack rate
= No. of exposed persons developing diseases/Total no.
of exposed/susceptible contacts 100
Total no. exposed are 100 10 = 90
Out of these 15 who were immunized are not susceptible.
So no. susceptible are 90 15 = 75
Secondary attack rate = 35/75 100
= 46.66%
2. The 1994 MYP of a place was 5,000. There were 750 children below 5 years,
and 500 from 5 to 10 years.
A lameness survey revealed that 4 of the children 5 to 10 years were lame.
Determine the annual incidence of:
a. Paralytic and
b. All cases of poliomyelities in the total population.
Sol. Prevalence of polio in children of 5 to 10 years:
= Polio cases in 5-10 age group/Population of 5-10 age
group 1000
= 4/500 1000 = 8 per 1000
Correction for those cases not involving lower extremities:
= Prevalence of polio in 5-10 years group 1.25
= 8 1.25 = 10 per 1000
Average annual incidence rate of 0-4 years:
= Corrected prevalence/No. of years of risk = 10/5 = 2 per
1000
a. Annual paralytic incidence for whole population:
= Average incidence of 0-4 years proportion of
0-4 population
= 2 750/5000 = 0.3 per 1000
b. Incidence of all cases of poliomyelitis:

= Annual incidence 1.33
= 0.3 1.33 = 0.399 per 1000
3. The average daily calorie consumption of a weighing 60 kg person is 2770,
and the protein intake 60 G. Determine his percent protein calories and
comment.
He is currently taking 100 G. Eggs daily and no groundnuts. He wishes to
replace eggs with groundnuts. How much of the latter he must eat so that it
furnishes him the same amount of absorbed protein as 100 G of eggs ? If the
cost of egg is 2.50 per 100 G and of groundnuts, 25 per kg, how much less/
more he have to spend ?
Sol. a. Percent protein calories
= Energy given by protein/Total energy 100
= 60 4.1/2770 100 = 8.88%
This is within the required range of 7 to 12 percent
b. Net protein utilization of egg is 96 percent
100 G of eggs have 13.3 G of Protein
of this 96/100 13.3 or 12.77 G is net protein utilization
Net protein utilization of groundnut is 55 percent
To get 55 G of protein utilization in this body 100 G of nut protein
have to be consumed.
So to get 12.77?
(12.77/55) 100 = 23.22 G of Groundnut protein.
The percentage of protein is 25 percent so 23.22 G of Groundnut
protein will be obtained from 23.22 100/1000 = 93 G
So, 100 G of egg costing 2.50 rupees should be replaced by 93 G
of groundnut costing 93 25/1000 = 2.33 rupees.
Therefore, he will be saving 2.50 2.33 = 0.17 rupees.
4. The estimated MYP of place for 1994 was 9,000. Its CBR was 30/1000
population IMR, 80/1000 live births and under 1 to 3 mortality 10/1000
children below three years.
a. How many packets of ORS and how many tablets of septran with
20 mg. Methoprim and 100 mg, Sulphamethoxazole will be required for
the treatment of episodes of acute diarrheal and respiratory diseases,
respectively ? No change in the incidence is expected.
b. A mass polio-immunization camp is planned for January and another
for February 1995 in which all children below three years would be given
polio vaccine irrespective of previous history of vaccination. Determine
the vials of oral polio vaccine that will be required. How many vaccine
carriers will be needed to carry the vaccine to different immunization
centers?
c. The place is being brought under CSSM Program in 1995. How many
bottles of vitamin A concentrate will be required for carrying out vitamin
A prophylaxis among infant during 1995?
Problems 401
Sol. a. i. Under 5 population is 15 percent

Under 5 population = 15 percent of 9000 = 1,350
Average incidence of diarrhea is 2.5/epiosde/year/child.
Total episodes of diarrhea in under fives:
= 1,350 2.5 = 3,375
Only 10 percent require ORS packets.
That is 337.5 or 338 children require ORS packets.
Two packets per episodes with wastage of 30 percent
ORS packets required = 338 2 + 30 wastage
= 676 + 203
= 879 packets of ORS.
ii. Incidence of respiratory diseases under 5 is 3 episodes/year/
child.
No. of episodes in 1350 children = 1350 3 = 4,050
Fifteen percent episodes or moderate or severe which need
drug.
15% of 4050 = 608 episode need drug.
Each episode needs 2 tablets bd for 5 days, that is 20 Tablets
per episodes.
Total No. of Tablets = 608 20 = 12,160
b. To find the estimated population of Under 3, the following
formula is used.
Estimated under 3 population:
= 3 MYP Birth rate as decimal
(1-3 Death rate under 3 as decimal)
= 3 900 0.03 (1-3 0.01) = 785.7 or 786
Total doses of OPV required to immunize 786 under 3 children
for second rounds:
2 no. of children WMF = 2 786 2 = 3144
1 OPV vial has 20 doses.
OPV vials required = 3144/20 = 157.2 or 158
So, for 1st round 79 vials and second round also 79 and each
vaccine carrier accommodates 15 vials.
Vaccine carriers need = 79/15 = 5.2 or 6
Six vaccine carriers will sufficient for both round.
c. Estimated infants under one year:
= MYP Birth rate as decimal (1-IMR as decimal)
= 9000 0.03 0.92 = 248.4 or 249.
One lakh IU of vitamin A for 1 baby Under 1 years is required:
So, for 249 babies 249 lakh IU of vitamin A is required:
One bottle of vitamin A = 100 Ml
Each 1 ml = 1 lakh IU of vitamin A
Therefore, for 1 lakh IU we require 1 ml
For 249 lakh IU we require 249 ml, bottles are therefore 3
5. a. 50,000 liters of water with fluorine concentration of 0.4 mg/L have to be

fluoridated so as to bring the concentration to 1 mg/L determine the
quantity of sodium fluoride required.
b. During 1994, in an industry employing 1,000 workers, 200 remained
absent. Of the later 10 were absent each for one day only; 20 for 2 days each;
30 for 4 days each, 40 for 6 days each; 60 for 12 days each and the remaining
for 14 days each. Calculate the absenteeism rate of this industry for 1994.
Sol. a. Fluorine concentration is 0.4 mg/liter.
Therefore, to get concentration of 1 PPM add 0.6 mg of fluorine
per liters water.
Sodium fluoride contains 45 percent fluorine ions.
That is 1 mg Sodium fluorine gives 0.45 mg of fluorine.
Therefore, to get 0.6 mg fluorine sodium fluoride added is:
= 0.6/0.45 = 1.33 mg
Therefore, to get 1 PPM fluorine level, add 1.33 mg/liter of
Sodium fluoride.
Required Sodium fluoride for 50,000 liters of water:
= 1.33 50,000 mg
= 66,500 mg = 66.5 gm.
No. of days absent No. of workers Total no. of days of absenteeism
10 1 10
20 2 40
30 4 120
40 6 240
60 12 720
40 14 560
Total 1690
b. Absenteeism rate
= Total no. of days of absenteeism/Total no. of workers
= 1690/1000 = 1.69 days/head/year
6. In June 1989, an epidemic of acute gastroenteritis occurred in a village.
There were 160 cases of which 20 died. There are two wells in the village.
Well A is in the north which is used by 600 persons; 120 cases were noted
among them. Well B in the south is the source of water for the remaining
1000 persons among whom 40 cases were recorded.
The age and sex-distribution of the population of the village along with the
cases and deaths in each age sex group is shown below.
Problems 403
Age Males Females

group Pop. Cases Deaths Pop. Cases Deaths
0 130 30 12 120 20 8
5 200 40 0 180 20 0
15 270 25 0 300 15 0
35 150 10 0 100 0 0
55 and above 70 0 0 80 0 0
Total 820 105 12 780 55 8
a. Analyze and interpret the above data.
b. What further information is necessary to elucidate the epidemiology of the
epidemic?
Sol. a. Analysis and interpretation:
i. Attach rate = 160/1600 1000 = 100/1000 population.
ii. Case fatality rate = Deaths/Cases 100
20
= 100 = 12.5%
100
iii. CFR under 5 = Deaths < 5/Cases < 5 100
= 20/50 100 = 40%
Comment: All the deaths under five years. None in older
children. This may be due to complicity of malnutrition in
under fives.
iv. Attack rate in males = 105/820 1000 = 128/1000 males.
Attack rate in Females = 55/780 1000 = 70.5/1000 females
Comment: The disease is 128/70.5 or 1.8 time more in males.
v. Attack rate in different age groups:
Cases in that age group/Total persons in that age group
1000
a. 50/250 1000 = 200/1000, children below 5
b. 60/380 1000 = 157.9/1000 children 5 -< 15
c. 40/570 1000 = 70.2/1000 persons 15 - < 35
d. 10/250 1000 = 40/1000 adults 35 - < 55
e. 0/150 1000 = Zero after 55 years
age group
Comment: There is steady decline in the attack rate with rise
in age up to 54 years. After 55 there are no cases. A
vi. Well A/Attack rate = 120/600 100 = 20%
Well B attack rate = 40/1000 100 = 4%
Is this difference statistically significant.
Ho: There is no difference in the attack rates.
|P1 P2 |
Test criteria is Z =
SE( P1 P2 )
p1 q1 p2 q2
= SE( P1 P2 ) =
n1 n2
20 80 4 96
SE( P1 P2 ) = = 1.75
600 1000
20 4
Z = = 9.14
1.75
Here Z = 9.14 > 1.96 reject Ho
Therefore p.001
Therefore, rejected null hypothesis = 1.75
Comment: This epidemic is due to contamination of the water
of well A.
Miscellaneous Problems
1. 2000 smokers and 1000 matched non-smokers were followed-up. Lung cancer
developed in 120 smokers and 20 nonsmokers. Find the absolute risk, relatives
risk, attributable risk of lung cancer in smokers and comment on them.
Persons with Persons without Total
lung cancer lung cancer
Smokers 120(a) 1880 (b) 2000 (a+b)
Non-smokers 20 (c) 980 (d) 1000 (c+ d)
Sol. Absolute Risk = Incidence of disease among smokers.
= a/a + b = 120/2000 = 0.06 or 6%
Relative risk
= Ratio of incidence of lung cancer between smokers and nonsmokers
a / a b a (c d ) 120 1000
= 3
c / c d c ( a b) 20 2000
Attributable risk
= incidence (risk) of disease that is attributed to smoking
a c

ab cd
= 100
a
ab
0.06 0.02
= 100
0.06
0.04
= 100 66.6%
0.06
Problems 405
Comments:
Lung cancer is three times commoner in smokers than non-
smokers.
Lung cancer among 66.6 percent smoker is due to smoking, the
rest due to background effect.
Results of other studies in other part of world should be
considering before concluding there is casual relationship between
smoking and lung cancer.
2. According to past records the hookworm prevalence rate in a community is
25/1000 population. It is decided to conduct a fresh hookworm survey. Determine
the size of the sample for this survey, allowing an error of 10 percent with
a confidence limit of 95 percent.
The formula to calculate the sample size with 95 percent confidence limit
with d percent error is true prevalence p of disease is:
4pq
n , where q = 1 p
d2
Sol. Given information:

Prevalence of hookworm = p = 25/1000 = 0.025
q = 1 p = 0.975
Error allowed = d = 10% of p = 10% of 0.025 = 0.0025
4 pq 4 0.025 0.975
4pq 4 0.025 0.975

Required sample size n =
d 2
(0.0025)2
0.0975
= 15600
0.000000625
3. The 1993 estimated mid-year population of a town was 200,000. The numbers
of registered vehicles during the year were 5,000. Of these 100 were not
driven during 1993 at all. The average number of KMS per day run by the
remaining vehicles is given below:
1,900 vehicles 10
2,500 vehicles 50
500 vehicles 100
The numbers of persons killed in motor vehicular accident in 1993 were 500,
of which 400 were the occupants of vehicles. Calculate all possible accident
fatality rates.
Sol. 1. Accident death rate per 100,000 population

Deaths due to accidents
= 100000
Mid-year population
= (500 100,000)/200000= 250/100000 population.
2. Death rate per 1000 registered vehicles = 500 1000/5000
= 100/1000 registered vehicles.
3. Total vehicle kilometers are
= (1900 10) + (2500 50) + (500 100) 365
= (19000 + 125000 + 50000) 365
= 70,810,000
Death rate per 100,000 Vehicle kilometers
= 500 100,000/70,810,000
= 0.7/100,000 vehicle kilometer
Death rate of vehicle occupants per 1000 vehicles per year
= 400 1000/5000 = 80/1000 vehicle occupants.
4. A new screening test for a certain disease was administered to 490 persons,
60 of whom are known to have the disease. The test was positive in 50 of the
persons with the disease, as well as in 20 persons without the disease. Calculate
the following:
a. Sensitivity of the test
b. Specificity of the test.
c. Percentage of false positive
d. Percentage of false negatives
e. Prevalence of disease
f. Predictive value of a positive test
g. Predictive value of a negative test.
Screening test Diagnosis Total

results Diseased Non-diseased
Positive 50 (a) 20 (b) 70 (a + b)
Negative 10 (c) 400 (d) 410 (c + d)
Total 60 (a + c) 420 (b + d) 480
Sol. a. Sensitivity of screening test = a/(a + c) 100
= 50/60 100 = 83.33%
b. Specificity of screening test = d/(b + d) 100
= 400/420 100 = 95.24%
c. Percentage of false positives = b/(b + d) 100
= 20/420 100 = 4.76%
d. Percentage of false negatives = c/(a + c) 100
= 10/60 100 =17.67%
Problems 407
e. Prevalence of disease = a + c/(a+ b+ c+ d) 100

= 60/480 100 =12.5%
f. Predictive value of positive test = a/(a+b) 100
= 50/70 100 = 71.43%
g. Predictive value of negative test = d/(c + d) 100
= 400/410 100 = 97.56%
5. In a clinical trial, 240 patients suffering from depression were included.
These matched groups were made. The first was put on drug A second on
drug B and third on a placebo. The results of the trial are shown below:
Drug/ No. felt No. felt No. Total
placebo better worse unchanged
A 47 6 29 82
B 52 3 22 77
Placebo 32 16 33 81
Determine if drug A is statistically more effective than B
Sol. To compare efficacy of drug A with B, exclude placebo results from
analysis. Also club the results not felt worse and number
unchanged as not felt better. The results can be tabulated as:
Drug No. felt better No. felt worse Total
A 47 (a) 35 (b) 82 (a+ b)
B 52 (c) 25 (d) 77 (c+ d)
Total 99 (a+ c) 60 (b+ d) 159 (N)
Null hypothesis: Drug A and B are equally effective
2
Use Chi-Square test. for 2 2 table is:
2 2
= (ad bc) N/(a+b) (c + d) (a + c) (b + d)
2
= (645) 159/99 60 82 77
= 66147975/37505160= 1.763
Degree of freedom = (r 1) (c 1) = (2 1) (2 1) = 1
For one degree of freedom, 2 value at 0.05 level of significance is
3.84. The calculated 2 is less than critical value of 2. Therefore,
accept null hypothesis. Therefore, drug A is not more effective
than drug B.
Chapter
30 Visits
CHAPTER OUTLINE
INTEGRATED COUNSELING AND TESTING CENTER (ICTC)
VISIT TO BLIND SCHOOL
A VISIT TO DEAF AND DUMB SCHOOL
VISIT TO DISTRICT HEALTH LABORATORY
VISIT TO PRIMARY HEALTH CENTER (PHC)
POSTPARTUM CENTER
DELIVERY OF INTEGRATED SERVICES FOR MATERNAL AND CHILD HEALTH, FAMILY
PLANNING, NUTRITION AND IMMUNIZATION
THE BABY FRIENDLY HOSPITAL INITIATIVE
WORLD BREASTFEEDING WEEK
ANGANWADI
INTEGRATED CHILD DEVELOPMENT SCHEME
VISIT TO DISTRICT TUBERCULOSIS CENTER
VISIT TO DISTRICT REHABILITATION CENTER
VISIT TO PLACES OF NATURAL CALAMITIES
SCHOOL HEALTH SERVICE
VISIT TO DISTRICT LEPROSY CENTER
INTEGRATED COUNSELING AND TESTING CENTER (ICTC)

An Integrated Counseling and Testing Center (ICTC) is a place where
person is counseled and tested for HIV, on his own or advised by a medical
provider. This common facility will remove fear, stigma and discrimination
among the clients. The ICTCs have common televise and video-based
health education material that are screened continuous in the waiting area.
The main functions of ICTC include:
1. Early diction of HIV
2. Provision of basic information on modes of transmission and
prevention of HIV/AIDS for promoting behavioral change and
reducing vulnerability.
3. Link people with other HIV prevention, care and treatment services.
Strategies adopted in ICTCs for HIV testing:
Opt out and opt in strategy
Opt out strategy.
Provider-initiated counseling and testingopt out: There are three
varieties of patients who are offered provider counseling and testing:
a. Patients who present at a health facility with symptoms suggestive of
HIV infection (pneumonia, TB and persistent diarrhea).
b. Patients with STI/RTI.
c. Pregnant women who register at antenatal clinic.
Visits 409
In such cases the client in given basic information on HIV, and educated
about testing for HIV. The counselor will ask each client, Do you wish to
test for HIV or not? The client can opt out or choose not to test for HIV.
If a client does not opt out then he/she is tested for HIV.
Client initiated counseling and testing opt in or Direct walk in client.
These clients who present themselves at the ICTC of their own free will
based on their individual risk behavior or information and advice received
from a friend, sexual partner, or outreach worker or peer educator. Here
the client is counseled for HIV and then opts in or actively aggress to be
tested for HIV. Written consent has to be obtained from such clients before
testing.
ICTC can be located in the Obstetric and Gynecology Department for
pregnant women, or with tuberculosis microscopy center for TB patients
at work place, on national highways and on universities.
There are two typed of ICTCs:
1. Fixed facility ICTC
2. Mobile ICTCs.
A fixed facility ICTC can be two types:
Stand alone ICTC having full time counselor and a laboratory
technician located in medical colleges and district and in some sub-
district hospitals. It is envisaged under NACP-III to have such ICTCs
established up to the level of CHC.
Facility-integrated ICTC which does not have full time staff and
provides HIV counseling and testing as a service along with other
services. Such center canters to small number of clients.
VISIT TO BLIND SCHOOL

In India, there are 140 blind schools of which 4 are in Karnataka in Hubli,
Davangere, Mysore and Gulbarga; Blind School at Davangere is exclusively
for girls.
Admission Criteria
Students are admitted in the month of June-July every year the students
should be blind and should produce a certificate from an ophthalmologist.
He should also produce an age certificate, a caste certificate in case of a
SC, ST student, also three passport size photos. Age group for admission
into 1st Std is 6 to 10 years. In case of an orphan a certificate from the
magistrate is needed. There is no admission fees.
Government Authority
The school is government school under the directorate of disabled welfare
which looks after the blind, physically handicapped, deaf and dumb,
mentally handicapped and those suffering from cerebral palsy.
Everything is provided free of cost. Besides education the other facilities

for blind are:
1. KSRTC has completely exempted the travelling charges for blind people
in ordinary buses.
2. In the Indian Railways, the blind persons has to pay only 25 percent of
the fare. For travel of the person needs an escort, the escort also has to
pay only 25 percent of the fare.
3. They are given Rs 125/- month as disabling allowance.
4. The blind students get a readers allowance of Rs 50 per month.
Syllabus for the Blind

There is no exemption in the syllabus for the blind up to VII Std but after
VII Std instead of mathematics and science, they can study economics,
political science, music and history ( choose any two subjects). The special
script for blind is called Braille script. Invented by Louis Braille (divine
life for blind).
Staffing Pattern
Consists of 24 members. In which are included the superintendent, teachers
with physical director to look after the affairs of the school. There is also
one visiting medical officer.
Specific Program for Prevention of Blindness

1. Vitamin A prophylaxis program
2. Trachoma control program
3. School age health services.
National and International Agencies

1. National Association for Blind (NAB) established in 1962.
2. Royal Common Wealth Society for Blind (1950).
3. International Agency for Prevention of Blindness.
4. Danish International Development Association (DANIDA).
A VISIT TO DEAF AND DUMB SCHOOL

There are four government schools in Karnataka:
1. Mysore upto SSLC
2. Gulbarga upto 7th Standard
3. Bellary upto 7th Standard
4. Belgaum upto 7th Standard
The Belgaum school is only for girls, rest all are only for boys.
Visits 411
Staffing Pattern
1. Gazetted postSuperintendent.
2. Two FDA (1st division assistant).
3. Two SDA (2nd division assistant). They look after the administration
and other problems individually.
4. Matron: Food, clothing, bedding are provided by him.
To assist them more in cooking staff two cooking posts.
5. Four graduate assistants who teach upto high school.
6. One primary school teacher undergraduate.
7. One tailoring instructor.
8. Two weaving assistants.
9. Night watchman.
Rules and Regulations

Boys and girls 6 to 10 years are admitted along with their records.
1. Birth certificate from municipality corporation, panchayat.
2. Income certificate and caste certificate from Tahsildar.
3. Photographsfour.
The capacity of student accommodation is 100 in each school. The govern-
ment is providing training facilities to all teachers. Teachers training
institute are formed for this purpose now it is at Bangalore.
There are two categories:
1. Institute for oral training
2. Institute for sign training.
VISIT TO DISTRICT HEALTH LABORATORY

In each district there is one district health laboratory.
Staffing Pattern
1. Medical Officer 1
2. Senior Laboratory Technician 4
3. Attender 4
4. Peon 2
5. Sweeper 1
Functions
1. Preparation of stain for all PHCs.
2. Conducting malaria clinics.
3. Surveillance: (a) Active surveillance, (b) Passive surveillance.
4. Training for paramedical staff.
5. Examination of malaria slides from all PHCs and rural sub-centers.
6. Routine laboratory work: Total count, differential count, ESR, Hb%,
VDRL, pregnancy test.
Urine Test: Bile salts, bile pigment, sugar, albumin and microscopic
examination. Stool examination for ova and cyst.
Staining Procedure for Malarial Smear
The stain used for this is JSB stain (Jaswant Singh Bhattacharya). Two
solutions of JSB are usedJSB 1 solution and JSB 2 solution. After
dehemoglobinization of the smear, dip the smear in JSB2 solution for 30 to
40 seconds which contains eosin. Wash it with buffer water containing KPO4
and disodium hydrogen phosphate. Then dip in JSB1 solution for
30 to 40 seconds and again wash with buffer water. Dry it and examine
under oil immersion lens using liquid paraffin. JSB1 solution contain
methylene blue, water, etc.
VISIT TO PRIMARY HEALTH CENTER (PHC)
The National Health Plan (1983) proposed reorganization of primary health
centers on the basis of one PHC for every 30,000 rural population in the
plains, and one PHC for every 20,000 population in hilly, tribal and
backward areas for more effective coverage. As on 30th June 1999, 22807
primary health centers have been established in the country against the
total requirement of about 23,000.
Functions of the PHC

1. Medical care
2. MCH including family planning
3. Safe water supply and basic sanitation
4. Prevention and control of locally endemic diseases
5. Collection and reporting of vital statistics
6. Education about health
7. National Health Programsas relevant
8. Referral services
9. Training of health guides, health workers, local dais and health assistants
10. Basic laboratory services.
Staffing Pattern
At present in each community development block, there are one or more
PHCs each of which covers 30,000 rural population. In the new set-up
each PHC will have the following staff:
At the PHC Level

Medical Officer 1
Pharmacist 1
Nurse midwife 1
Visits 413
Health worker (Female) ANM 1

Block extension educator 1
Health assistant (Male) 1
Health assistant (Female)/LHV 1
UDC 1
LDC 1
Laboratory technician 1
Driver (subject to availability of vehicle) 1
Class IV 4
15
At the Sub-center Level
Health worker (female)/ANH 1
Health worker (male) 1
Voluntary worker
(Paid Rs 50 per month as honorarium) 1
3
POSTPARTUM CENTER
Introduction
The history of postpartum concept dates back to the year 1966 when the
Population Council, New York, developed an International Program to
test the idea that the post delivery (or postpartum) period is the point of
highest motivation for family planning and therefore the best occasion
for providing information and service. Government of India launched the
All India Hospitals Postpartum Program in 1969.
The postpartum program has been defined as A maternity centered
hospital based approach to Family Welfare Program to motivate women
with in the reproductive age group (15-44 years) or their husbands for
adopting small family norms through education and motivation
particularly during prenatal and postnatal period.
Over a period of years the concept of postpartum program has
undergone a change. The service of the postpartum center now include
MCH and Family Planning Services. The postpartum centers function as
referral centres for peripheral institution.
It ensures effective Obstetric Services leading to decline in maternal
and infant mortality and better acceptance of family planning methods
(Table 30.1).
Table 30.1: Staff pattern of the postpartum center attached to medical college
1. Assistant Professor in OBG 1
2. Lecturer in Health Education and FP 1
3. Lecturer in Statistics and Demography/ 1
Lecturer in Social Preventive Medicine
4. Lecturer in Pediatrics 1
5. Anesthetist (Asst. Surgeon Gr.I) 1
6. Projectionist-cum-Mechanic 1
7. Medical Officer (1 Male and 1 female) 2
8. Public Health Nurse/LHV 1
9. Auxilliary Nurse Mid-wife 2
10. Family Welfare Worker (M) 1
11. Store Keeper cum/Clerk 1
12. Steno-typist 1
13. LDC 1
14. Driver 1
15. Attendant 1
16. Cytotechnician 1
Functions of Postpartum Unit

The Postpartum Unit as a whole is responsible for carrying out the
following functions.
A. To provide contraceptive advice and services primarily to obstetric
and abortion cases attending the Department of Obstetrics and
Gynecology and various other Departments, knowledge regarding
available methods and follow-up of acceptors, in addition to this,
advice/service treatment of infertility for both male and female
recanalization.
B. To provide out reach services and extend material and Child Health
Family Welfare Hospital. This all should cover at least a population of
50,000 or the whole town if the population is less than 50,000.
C. Immunization of all children delivered at the Postpartum Center and
those attending hospital Outpatient Department. To provide nutritional
education to women during antenatal, correct methodology of weaning
of the child. Health education on prevention of anemia, protein
malnutrition and vitamin A deficiency in addition to other diseases
also needs to be imparted. The above services shall also be provided to
the community of the field area.
D. To involve all the departments and staff of the hospital in addition to
the Department of Obstetrics and Gynecology in the Family Welfare
Program.
E. To detect early cases of cervical cancer among users and not-users of
family welfare methods through Postpartum Pap Smear test facilities
wherever such facility is provided under the Postpartum Program.
F. To conduct teaching and training program in family welfare for under
graduate and postgraduate medical and paramedical students.
Visits 415
G. To develop an over all plan for distribution of conventional contra-

ceptives and identify depot holders to meet the demand of the people
in the area served by the Center.
H. To participate in the State Level Seminar and suggest methods for
improving the Program and removing the bottleneck if any.
Department of Obstetrics and Gynecology
Shares the major responsibility of implementing the program while the
other departments viz. Pediatrics, Surgery and Preventive and Social Medicine
supplement the efforts of the Department of Obstetrics and Gynecology.
In the case of non-teaching hospitals, the Medical Superintendent or Civil
Surgeon acts as Program Director and Senior Medical Officer as Project
Officer.
Monitoring and Evaluation Aspects
Program monitoring is considered as one of the most essential tools for
the successful implementing of the program. It helps in studying day-to-
day developments to the program.
Institutional Level Monitoring and Evaluation

At institutional Level the program is monitored by way of maintaining
proper records like eligible couple survey register of field area population
served, acceptors motivated at various intervals of time, etc. and evaluated
by Coordination Committee constituted in every Institution as per the
norms suggested by Government of India.
Guidelines for Constitution of Coordination Committee

In order to evaluate and review the working of the program and to bring
about further improvement in effective functioning of the program,
Coordination Committees are formed in all the Medical Institutions
Hospital/covered under the program. The composition of the Co-ordination
Committee may be as follows (Table 30.2).
Table 30.2: Composition of the coordination committee
1. Program DirectorPrincipal/Dean in case of Medical Chairman
College/Teaching Institution Medical Superintendent/Civil
Surgeon in case of nonteaching Hospital/Institution
2. Project DirectorHead of the Department of Obstetrics of Member
Gynecology
3. Head of the Department of Pediatrics Member
4. Head of the Department of Preventive and Social Medicine Member
5. Head of the Department of Surgery Member
6. Regional Director (H and FW, Government of India) Member
if available
7. State Family Welfare Officer/District, Family Welfare Officer Member
or any person outside the Medical College
May be co-opted as Member at the discretion of the
Chairman if necessary
In those Postpartum Units where Pap Smear Test Facility has been
sanctioned, Professor of Pathology/Cytopathologist may be co-opted as
member of coordination Committee.
Broad Functions
The broad functions of the committee in an institution are:
I. To evaluate and review the progress of the postpartum program.
II. To adopt corrective measures for improvement of the program.
III. To meet at least once in three months.
IV. To apprise State Government of the development taking place in the
field.
DELIVERY OF INTEGRATED SERVICES FOR MATERNAL AND

CHILD HEALTH, FAMILY PLANNING, NUTRITION AND
IMMUNIZATION
The health of the mother and child are interviewed so that the services of
maternal and child health, family planning, nutrition and immunization
are closely and required to be delivered as an integrated package of family
health care. This is indicated in Figure 30.1.
Fig. 30.1: Integrated family health care

Visits 417
THE BABY FRIENDLY HOSPITAL INITIATIVE
What is BFHI?
This is global program aimed at giving quality care to mothers and children
and to ensure that every newborn baby gets the best start in its life. The
program commits itself to protecting, supporting, and promoting
breastfeeding.
Why this Program?
It is generally felt that all mothers in this part of the world breastfeed their
babies anyway. So why worry about such a program?
If we think for a moment and apply our mind to this situation, we all
know that there are many mothers who deliver a baby for the first time,
many more mothers are delivered by cesarean section (this figure is on
the increase especially among urban mothers), one-third of the babies born
in our state are low-birth weight and nearly 12 to 15 percent are preterm
babies Mothers delivering with episiotomy wound and forceps extraction
are also quite a few. These are situations found by each one of us wherein
newborn babies and mothers have breastfeeding difficulties.
Studies conducted from 222 villages of Central Karnataka has shown
that rural mothers delay the first feed, administer prelacteal feeds, quite a
few discard colostrum considering that it is unsuitable to the child and
exclusive breastfeeding is not optimally practised. Quite a few mothers
bottle-feed their babies.
Taking all these points into consideration, we have to conclude that
where ever there is a maternity service and where ever there are lactating
mothers there must be high level of expertise available among MCH care
staff to deal appropriately with any lactation management difficulty.
Hence, this program is very relevant to us.
What is New About it?
Lactation management focuses its attention on understanding the
physiology of the newborn and parturient mothers and critically looks
at factors that govern initation and establishment of lactation.
The dynamics of breast milk transfer is now understood in proper
perspective. We now know that baby should attach in a good position
and its tongue should remove all the milk from the lactiferous sinuses
(the reservoirs of milk). Complete emptying results in more production
of breast milk.
Early initiation results in practical disappearance of breast engorgement

Sore nipples, fissures, cracks and pain experienced by the mother while
breastfeeding are the result of nipple feeding.
The art of manual expression of breast milk tries to mimic the action of
baby at the mothers breast.
What is this Program All About?

Can it be Simply Described in a Few Words?
Yes, the program comprises of:
A. Ten simple steps that should be implemented in a maternity service.
B. Learning five basic skills by all the MCH care staff.
The Ten Steps

1. Have a written breastfeeding policy that is routinely communicated to
all health care staff.
2. Train all health care staff in skills necessary to implement this policy.
3. Inform all pregnant women about the benefits and management of
breastfeeding.
4. Help mothers initiate breastfeeding within half an hour of birth.
5. Show mothers how to breastfeed and how to maintain lactation even
if they should be separated from their infants.
6. Give newborn infants no food or drink other than breast milk unless
medically indicated.
7. Practice rooming-in allowing mothers and infants to remain together
24 hours a day.
8. Encourage breast-feeding on demand.
9. Give no artificial teats or pacifiers to breastfeeding infants.
10. Foster the establishment of breastfeeding support groups.
The Five Basic Skills

1. To learn the skill of initiating breastfeeding and to assure that baby is
placed in a good position at the mothers breast.
2. To learn the skill of manual expression of breast milk.
3. To learn how to prevent and treat insufficient milk supply.
4. To learn how to prevent and treat sore nipples.
5. To learn how to prevent and treat breast engorgement.
What are the Benefits of Making

My Hospital Baby Friendly?
There are many benefits of making my hospital baby friendly:
1. Firstly you will have the satisfaction of providing scientific and updated
information and technical help to lactating mothers.
2. Infant mortality will come down.
Visits 419
3. Your hospital staff will work as a cohesive team and will derive pride
in their work.
4. Your hospital will get National and International recognition.
5. This program will place us on a global forefront.
What are the Investments Needed and

What is the Cost Involved?
Nothing. There is no financial involvement. However, you will have to
spend lots of time training your MCH care staff.
What should I do to get My Hospital

Recognized as Baby Friendly Hospital?
The steps are three folds:
1. Obtain self-assessment form.
2. Complete the form, Xerox two copies and send to coordinator baby
friendly hospital initiative for Karnataka State (Retain one copy with
you).
3. Train your health care staff and await inspection.
WORLD BREASTFEEDING WEEK

Each year we have been observing World Breastfeeding Week from 1st
to 7th August every year. We all know that exclusive breastfeeding for
the first six months and continued breastfeeding for two years along with
home made semi solids, is the best way of bringing up a child.
Most mothers in our country want to breastfeed their children.
Though 90 percent of mothers are successful in breastfeeding their
children, primi mothers, mothers delivering by LSCS and mothers
having preterm and low-birth weight children more often have
breastfeeding difficulties.
What are Our Problems?
Delayed Start
Mothers usually delay the first feed for three days and offer cows milk,
honey, sugar water using cloth or cotton wisp. These pre-lacteal feeds are
unnecessary and can introduce infection in the baby. They also interfere
with the physiology of lactation and delay establishment of breast milk,
They can cause breast engorgement by 4th or 5th postnatal day.
Hence, we have to spread an important message that babies should
be put to breast in first half an hour of birth. During this period, the
neonate is awake, alert and all his neonatal reflexes such as rooting, sucking
and swallowing are very sharp. This is the right time when we should
initiate breastfeeding.
Mothers delivering by LSCS: Such mothers have lot of pain and difficulty
looking after themselves. Such mothers need the help of trained nursing
staff who are able to support and assist them with breastfeeding. The
number of LSCS deliveries are increasing. Hence, we have to create
adequate expertise in all maternity facilities.
Primi mothers: For these mothers, all said and done, it is their first
experience. Mothers have many doubts and fears about breastfeeding and
carrying for their young ones. They need to be adequately supported and
helped. Most difficulties are in the first few days after birth.
Working mothers: Mothers who have to return to work are constantly under
stress as to how to manage feeding once they return to work. Usually
such mothers end up bottle feeding their young ones inviting risks and
hazards of artificial feeding. There is explosion in knowledge and technical
expertise in helping such mothers.
Common breastfeeding problems: Sore nipples, mastitis, engorgement,
difficulty in positioning and breast refusal are some of the common
problems seen. These problems can be easily prevented by simple
measures because of better understanding of physiology of lactation and
breast milk transfer.
What can We do for the World Breastfeeding Week (WBW)?

There is tremendous amount of responsibility with each one of us to ensure
that no mothers will have any difficulty with breastfeeding their young
ones.
At individual level:
1. Every newborn baby that you come across, please make sure that the
baby is sucking in proper position.
2. Ensure that breastfeeding is initiated early and baby fed on demand as
frequently as needed.
3. Train Nurses to assist mothers delivering by LSCS with breastfeeding.
4. Help mothers in manual expression of breast milk in situation like-
baby very small or preterm, mother who has to return to work.
5. Create supporting environment for the mother.
6. Congratulate every mother who is doing well with breastfeeding.
7. Encourage every mother to exclusive breastfeed for six months.
8. Each one of us involved in neonatal care can contribute to better lactation
management in our day to day work, involving nurses and mothers.
At community level:
1. Organize talks and meetings with Pediatricians, Obstetricians, IMA
members and Medical Practitioners. Include all nursing staff in such
meetings.
Visits 421
2. Hold public meetings with Lions Club, Rotary Club and other such
Voluntary Organizations.
3. Organize meetings with Mahila Mandals and Womens organizations.
4. Give radio talks and TV talks.
5. Write in daily newspapers, magazines and other print media.
Promote BFHI Concept

The Baby Friendly Hospital Initiative aims at promoting, protecting and
supporting breastfeeding in the community.
Let us rededicate our efforts to help all mothers in attaining their best
in their role of child rearing. Please note that these activities are not limited
to just the week alone but should become a part and way of life.
Please plan your activities along with your District Branch President
and Secretary.
ANGANWADI
The focal point for the operation of the ICDS at the village level, is an
Anganwadi. It covers a population of about 1000 in urban and rural areas
and 700 in tribal areas. The worker who coordinates and offers the services
is the Anganwadi Worker (AWW).
Some of the important tasks to be performed by the AWW are as follows:
1. To survey the community and identify child and mother beneficiaries.
2. To monitor the growth of children using weight for age and identify
children suffering from malnourishment.
3. To maintain growth charts and records of attendance, immunisation,
births, deaths, etc. at the Anganwadi.
4. To provide supplementary feeding to children.
5. Assist the LHV in distributing Vitamin A to children and iron and folic
acid supplements to pregnant and lactating women; and refer patients
to local health services.
6. To teach nonformal preschool education to three to six years old children
and functional literacy classes for adult women.
7. To make home visits in order to enlist community and beneficiary to
supports various activities.
8. To organize womens clubs (Mahila Mandals) for health and nutrition
education and centers for income-generating activities.
INTEGRATED CHILD DEVELOPMENT SCHEME

A majority of Indias children live in impoverished economic, social and
environmental conditions which impede their physical and mental
development. As a response to the unmet needs of this vast and vulnerable
population, the Government of India introduced in 1975 its most ambitious
and comprehensive plan to increase child survival rates among the poorest
and enhance the health, nutrition and learning opportunities of pre-school
children and their mothers. Drawing upon experience called from twenty
years of planned social development, the Integrated Child Development
Scheme (ICDS) is designed both as a preventive and developmental effort.
If extends beyond the existing health and education systems to reach
children and their mothers in villages and slums and delivers to them an
integrated package of services.
Objectives
Its major objectives are to:
i. Reduce malnutrition, morbidity and mortality of children in the age
group 0 to 6 years
ii. Improve their health and nutritional status
iii. Provide the environmental conditions necessary for their psychological
social and physical development
iv. Enhance the ability of mothers to provide proper care to their children
v. Achieve effective coordination among various departments providing
developmental services to children.
Package of Services
To achieve these goals a package of services consisting of the following
was introduced:
a. Supplementary feeding (Details given in Table 30.3).
b. Immunization
c. Health check-up
d. Referral services
e. Nutrition and health education
f. Pre-school education and
g. Non-formal education for women.
Table 30.3: Nutritional supplements
Recipients Calories Grams of protein
1. Child up to 6 years 300 8-10
2. Adolescent girls 500 20-25
3. Pregnant and nursing mothers 500 20-25
4 Malnourished children Double the daily supplement provided to
the other children (600) and/or special on
medical recommendation
Organizational Set-up
The Ministry of Social Welfare is responsible for the budgetary control
and administration of the scheme forms the center and coordinates
activities with the Ministries of Education, Health Family Welfare and
Rural Development.
Visits 423
Fig. 30.2: Convergence of ICDS services
At the State level, the Department of Social Welfare is mainly responsible,

although in some states, other Departments (e.g. Tribal Welfare, Women
and Child Welfare, Health or Rural Development) may take primary
responsibility for implementation.
At the block level, the Block Development Officer (BDO) exercises
overall responsibility for the project, co-ordinating activities with
the main ICDS functionary, the Child Development Officer (CDPO)
(Fig. 30.2).
Anganwadi Worker
Anganwadi worker is a part-time trained voluntary worker and receives
an honorarium of Rs. 700 per month. She is assisted by a helper who is
also a local women and paid an honorarium.
Mukhya Sevika (MS)
Mukhya Sevika is a full-time worker who supervises the work of 20, 25
and 17 Anganwadi workers in urban, rural and tribal projects respectively.
She visits each Anganwadi at least once a month, and liaise with lady
health visitor in nutritional and health activities.
Child Development Project Officer

For one project there is one Child Development Project Officer (CDPO)
who cover one community development block having a population of
80,000 to 120,000. He or she supervises, co-ordinates and guides the work

of entire ICDS project as an in-charge and provide supervision to four to
five Mukhya Sevika. He is assisted by one assistant CDPO.
Achievements
New ICDS is effective in 5171 community development blocks and major
urban slums throughout the country. As against 2.27 crore beneficiaries
until March 1997, there were 3.4 crore beneficiaries in April 2001. Today
the scheme reached out to about 54 lakh expectant and nursing mothers
and 288 lakh children under six years of age belonging to the disadvantage
groups.
The type of services to be provided for target groups are given in
Table 30.4.
Scheme for Adolescent Girls (Kishori Shakti Yojna)

There was a gap in between women and child age group which was not
covered by any health and social welfare program whereas girls in this
crucial groups need special attention. On one side they need appropriate
nutrition, education, health education, training for adulthood, training
for acquiring skills as the base for earning an independent livelihood,
training for motherhood, etc. Similarly on the other side their potential to
be a good community leader has to be realized. A scheme for adolescent
girls in ICDS was launched by the Department of Women and Child
Development, Ministry of Human Resource Development in 1991.
Table 30.4: Type of services to be provided for target groups
Beneficiary Service
1. Expectant and nursing mothers i. Health check-up
ii. Immunization of expectant
mothers against tetanus
iii. Supplementary nutrition
iv. Functional literacy
2.Other women 25-45 years i. Nutrition and health education
ii. Functional literacy
3. Children less than 3 years i. Supplementary nutrition
ii. Immunization
iii. Health check-up
iv. Referral services
4. Children between 3-6 years i. Supplementary nutrition
ii. Immunization
iii. Health check-up
iv. Referral services
v. Nonformal preschool education
Visits 425
Common services: All adolescents girls in the age group of 11 to 18 years

(70%) receive the following common services:
1. Watch over menarche
2. Immunization
3. General health check-ups once in every six months
4. Training for minor ailments
5. Deworming
6. Prophylactic measures against anemia, goiter, vitamin deficiency, etc.
and
7. Referral to PHC/District hospital in case of acute need.
This scheme for adolescent is extended to 3.51 lakh adolescent girls in
507 ICDS blocks covering all states and union territories. It is proposed to
extend the scheme in 2000 community development blocks during ninth
plan covering 12.8 lakh adolescent girls.
VISIT TO DISTRICT TUBERCULOSIS CENTER
National Tuberculosis Program (NTP)

National Tuberculosis Program (NTP) has been in operation since 1962
NTP operates through the District Tuberculosis Program (DTP) which is
the backbone of the NTP. Over 600 TB clinics have been set up in the
country, of which 390 have been upgraded todate as District TB Centres
(DTC) to undertake districtwise TB control in association with general
health and medical institutions.
Organization
A District Tuberculosis Program consists of one District Tuberculosis
Center (DTC) and on an average 50 peripheral health institutions
comprising of PHCs, general hospitals, rural dispensaries, etc.
To implement the program, a specially trained team of key program
personnel (Trained at the National Tuberculosis Institute, Bangalore for a
period of 13 weeks) is posted at each DTC. The team consists of:
One District Tuberculosis Officer (DTO)
One Second Medical Officer
Two Laboratory Technicians
Two Treatment Organzer/Health Visitor
One X-ray Technician
One Non-medical Team Leader
One Statistical Assistant
One Pharmacist.
The program is integrated with primary health care system ( general
health services) and is brought within the ambit of the District Health
Organization. The District Health Officer is made directly responsible for
the DTP, with the DTO as a specialized staff officer to assist him in the
management of DTP. Not only the peripheral health institutions, but also
the caders of health workers and MPWs are all involved in the program
of case detection and treatment.
VISIT TO DISTRICT REHABILITATION CENTER

The Government of India launched District Rehabilitation Center (DRC)
scheme in early 1985, for providing a package of model comprehensive
rehabilitation services to the rural disabled. The scheme, at present is
operated in 11 different places of the country. The scheme covered:
(1) Locomotor handicap, (2) Speech and hearing impaired, (3) Visually
impaired, (4) Mentally handicapped, and (5) Multiple handicaps.
Services Provided
1. Preventive and early detection
2. Medical intervention and surgical correction
3. Fitment of artificial aids and appliances
4. Therapeutic services such as physiotherapy, speech therapy, and
occupational therapy
5. Provision of educational services in special and integrated school
6. Provision of training, for acquisition of skills through vocational
training, job placement in local industries and trade with proper linkages
with on going training and employment programs
7. Provision of self employment opportunities and bank loans
8. Establishing a meaningful linkage with existing government scheme
such as disability/old age pension, scholarship, etc.
9. Creating of awareness movement of community and family counseling.
At Village Level
Anganwadi worker, teacher, health workers, etc. undertake the work of
prevention, detection, and referral to PHC/CHC/District Hospital or
voluntary organizations.
At PHC/CHC Level
Medical officers and paramedical staff are trained and oriented to prevent,
detect, and appropriate intervention at their level and timely referral to
highest centers.
DRC Level
District unit:
1. Provide service to handicaps
2. Act as referral center to PHC/CHC and for village level staff
3. Organizing camps
Visits 427
4. Education, vocational training, coordinating work with voluntary

agencies and other departments.
Regional Rehabilitation Training Center were set up in Lucknow,
Chennai, Cuttack, Mumbai to provide technical support to the DRCs.
National Program for Rehabilitation of

Persons with Disabilities
National Sample Survey Organization of 1991 indicated 1.8 percent of the
population in the country as disabled which is now 1.9 percent and 2-2.5
percent has mental retardation. The prevalence rate of disability is 22.7
per 1000 males and 16.9 per 1000 females. Disability was more in rural
than urban areas and above national average in states of AP, HP, MP,
Karnataka, Orissa, Punjab, and Tamil Nadu.
Objectives
1. To create services delivery system at state/district block/gram panchayat
level so as to provide comprehensive based rehabilitation services.
2. Prevention, early intervention and information dissemination.
VISIT TO PLACES OF NATURAL CALAMITIES

WHO defines disaster as Any occurrence that causes damage, ecological
disruption, loss of human life, deterioration of health and health services,
on a scale sufficient to warrant an extraordinary response from outside
the affected community or area.
Disasters
Disasters are classified in various ways, e.g. natural versus manmade
disasters or sudden versus slow-onset disasters.
Phases of a Disaster (Fig. 30.3)

Predisaster phase: The phase before a disaster strikes is the pre-disaster
phase.
Alert phase: This phase refers to the period when a disaster is developing
and when it has not yet hit the community.
Impact phase: There is no well-defined impact phase for gradual onset
disasters, and sudden onset disasters are unpredictable in every way.
Post impact phase: This is the phase following the actual impact of the
disaster.
Reconstruction and rehabilitation phase: This is a long-term phase. It aims at
getting the community back to where it was before the emergency and to
strengthen its ability to prevent and/or mitigate other diseases.
Fig. 30.3: Prototype acute disaster cycle
Effect of Disasters on Health (Table 30.5)
Objectives of health disaster preparedness:

The objectives of disaster preparedness and response activities in the health
sector may be expressed as follows:
a. To prevent excess mortality due to the disaster, which may be caused
by the direct impact of the disaster, by delays in rescue and relief
activities, by lack of appropriate and timely health care, by the
disruption of the normal health care and breakdown of preventive
measures, and sometimes by malnutrition.
b. To provide appropriate and timely care for casualties due to the disaster.
These include injuries, trauma and burns in natural disasters;
malnutrition in situations of food shortage; acute cases of communicable
disease in epidemic outbreaks, etc.
c. To prevent exposure to adverse climatic and environmental conditions
including lack of food, water, sanitation, shelter, clothing, chemical or
nuclear exposure, etc.
d. To prevent short-term and long-term disaster related morbidity:
Outbreaks of communicable disease usually due to changes in the local
ecological conditions, disruption of health services, interruption of
control measures, lack of sanitation, overcrowding;
Increase in morbidity and mortality due to destruction of health
infrastructure and to the provision of basic health services;
Introduction of new diseases due to resettlement or imported by external
relief workers;
Occurrence of wide-spread malnutrition/under-nutrition.
Visits 429
Table 30.5: Effect of disasters on health
Effect Earthquake High wind Tidal waves/ Flood Drought

(without flash flood
floodings)
Deaths Many Few Many Few Moderate
Severe Overwhelming Moderate Few Few Moderate
injuries
requiring
extensive
care
Increase risk of Potential risk following all major
communicable diseases natural disasters
(Probability rising with overcrowding and deteriorating sanitation)
Food Rare (May Rare Common Common Common
scarcity occur due
to factors
other than food
shortage)
Major Rare (May Rare Common Common Common
population occur in
move- heavily
ments damaged
urban areas)
Under- Occasional Rare Occasional Moderate Common
nutrition/
Famine
e. To re-establish health services to or above pre-disaster levels, with
special attention to:
Reconstruction and repair of damaged health facilities;
Renovation of health facilities to adequate and appropriate level;
Reorganization of health services based on Primary Health Care.
Examples of Some Disasters
A few examples of disasters which are still fresh in the memory of living
generations are as under:
Atom bombing of Hiroshima (6 August 1945) and Nagasaki (9 August 1945):
During the second world war is regarded as the worst manmade disaster
of the century with estimated casualties of 120,000 and 75,000 respectively.
Guatemala earthquake (1976): In which 92 percent lost their homes, about
76,000 sustained injuries and some 23,000 got killed. A sample survey of
victims of this disaster brought out such startling findings as:
Eighty-four percent of the victims had no social security in the form
of insurance.
Forty-six percent were dissatisfied with the medical care received
by them.
Thirteen percent could not return to their former employment
because of their injury, i.e. they needed vocational rehabilitation.
Twelve percent had to wait 2-3 days and 16 percent for one week
before admission into a hospital.
Even for first-aid, 13 percent had to wait for 2-4 hours, 12 percent for
four to eight hours and 21 percent for two to three days.
Bhopal gas tragedy (1984): It is regarded as the worst air pollution disaster
so far and was due to accidental leakage of methylisocynate (MIC) from
its plant. It affected about two lakh people and claimed 1,754 lives,
according to one published report.
SCHOOL HEALTH SERVICE

School health is an important branch of community health. According to
modern concepts, school health service is an economical and powerful
means of raising community health.
Benefits of School Health Programs

School health programs have a beneficial impact on students, family, nation
and all people at large:
1. Investment in school health programs is the most efficient and cost
effective way to improve students health, and consequently their
academic performance. Beside the students, teachers and other staff
also get health benefits.
2. It has been estimated that 1.3 years of schooling to the mother reduces
child mortality by about 15 percent. More years of education a female
receives, the more likely it is that her children will survive the first 5
years of life (World Development Report, 1993).
3. School food programs also have a marked effect on attendance and
school performance.
4. Carefully designed and implemented comprehensive health education
curricula can prevent certain adverse behaviors, including tobacco use,
illicit drug use, unhealthy dietary practices, unsafe sexual behavior, and
physical inactivity.
5. Schools setting provides an efficient means of improving young peoples
health, self-esteem, life skills (abilities related to effective decision-
making, communication, understanding emotions, critical thinking,
coping with stress, etc.) and behavior. School can also provide the setting
to introduce health information and technologies to the community and
can lead the community by advocating policies and services that
promote health.
6. Schools can reach about one billion students worldwide everyday and,
through them, their families and communities that is the world broadest
and deepest channel for putting information at the disposal of its citizens
(UNICEF 1988).
Visits 431
Objectives of School Health Service

The objectives of the program of a school health service are as follows:
1. The promotion of positive health
2. The prevention of diseases
3. Early diagnosis, treatment and follow-up of defects
4. Awakening health consciousness in children
5. The provision of healthful environment.
School Health Program in India
Formal school health program is nonexistence in India. However, school
medical inspection was started first in Baroda city in 1909. In the succeeding
years practically every province in British India introduced some form of
school health program particularly in middle and high schools. But after
independence there was not much progress made in school health
program. At the government level, a School Health Committee was set
up in 1960 to review the program at national level. The committee
recommended that in the first phase (1962-66) school health services should
be developed in an area close to primary health unit to cover 40 primary
schools and in cities all primary school children in slums must be covered.
In the second phase (1966-71) these services should be extended to all
primary schools in both rural and urban area (GOI 1960-61). Again the
progress in this direction has been rather very slow (Lal 1998).
It is suggested by the School Health Committee that primary health
centers should also cover schools in their jurisdiction for health care
delivery including inspection. One PHC is responsible for more than 5000
students per year. In urban area school health service schemes are run by
corporation or nongovernmental organization.
Aspects of School Health Service

The tasks of a school health service are manifold, and vary according to
local priorities. Where resources are plentiful, special school health services
may be developed. Some aspects of a school health service are as follows:
1. Health appraisal of school children and school personnel
2. Remedial measures and follow-up
3. Prevention of communicable diseases
4. Health school environment
5. Nutritional services
6. First aid and emergency care
7. Mental health
8. Dental health
9. Eye health
10. Health education
11. Education of handicapped children

12. Proper maintenance and use of school health records.
VISIT TO DISTRICT LEPROSY CENTER
The distribution of leprosy within districts is quite uneven and equally
the services available in the districts for leprosy control vary considerably.
There are many reasons for this including the availability of number of
staff, difficult terrain, lack of logistic support and limited participation of
general health staff and community in program activities.
A district level leprosy elimination cell under the chairmanship of
CDMO with ADMO (PH), skin and orthopedic specialists of HQ hospital,
one LCU medical officer, MO incharge and one PHC medical officer as
members of the district leprosy cell could do the planning and monitoring
of leprosy elimination activities in the district. The district leprosy
elimination plan to be comprehensive should include all core activities
for leprosy elimination and take care to see that leprosy services reach every
patient in every village. The plan should be placed before the DLES and
sent to JDHS (Lep) for their information and approval.
District Infrastructure (Table 30.6)
Main Activities
The main activities are to be focused at the district level are:
To expand MDT services to all health facilities.
To treat all leprosy patients with MDT given free of cost.
To detect all leprosy cases undetected in the district and treat them
with MDT.
Capacity building at local level.
To inform and impart health education to community on leprosy and
seek their support.
Referral services for leprosy patients.
The prevention of disability (POD).
Monitoring, supervision and evaluation.
To promote health system research (HSR).
Table 30.6: District infrastructure according to endemicity level
District classification Infrastructure sanctioned
by prevalence levels Leprosy Control Units ( LCU): 1 per 4.5 lakh rural
at the start population
of phase-1-218 A LCU is manned by one Medical Officer (MO)
high endemic 4 Non-medical Supervisors (NMS) and 20
districts (PR>50/10000) paramedical workers
Modified LCUs: Rural areas
Urban Leprosy Centers (ULCs):1 per 50,000
population 1 PMW/NMS (reporting to the MO of a
dispensary or a hospital)
Contd...
Visits 433
Contd...
Temporary Hospitalization Wards (THWs): To provide
specialized services to leprosy patients with complica-
tions/problems. The THWs were supplemented by
limited number of centers identified that doing
restructured surgery
79 Moderately endemic 2 Mobile Leprosy Treatment Units (MLTU) for each
districts moderately endemic 1 MLTU for each low endemic
district
193 Low-endemic districts MLTU for leprosy patients at drug delivery with the
help of general health staff. Each MLTU consists of
following staff appointed on contract basic: MO-1,
NMS-1, PMS-2, Driver-1, Total 350 MLTUs
sanctioned in the country
SET Centers: Survey Education and Treatment Centers
attached to PHCs/hospitals in rural endemic pockets.
One SET covers 25,000 population. Staff one PMW
under the guidance of PHC medical officer
ULCs in urban endemic pockets
Goal of National Health Policy 2002

Elimination of Leprosy by 2005
Project Phase II 2000 Onward

The Project Implementation Plan (PIP) for the NLEP Phase II.
Part A: National plan setting out the project design for the country.
Part B: Plan for eight high endemic states (Madhya Pradesh, Orissa,
Bihar,Uttar Pradesh and West Bengal, Uttaranchal, Chhattisgarh,
Jharkhand)
Part C: Plan for the remaining 27 states and Union Territories
Project Phase II Objectives

1. To achieve elimination of leprosy at national level by the end of the
project.
2. To accomplish integration of leprosy services with the general health
care system in the 27 low endemic states/UTsunion territories.
3. To proceed with integration of services as rapidly as possible in the
eight high endemic states.
Project Phase II Components

1. Decentralization and institutional development
2. Strengthening and integration of service delivery
3. Disability care and prevention
4. Information, education and communication
5. Training.
BIBLIOGRAPHY
1. J Kishore, National Health Programmes of India, 4th edn, 2002.
2. Karnataka Paediatric Journal. April-Sept 2000;14:243
3. Parks Textbook of Preventive and Social Medicine, 16th edn, Nov, 2000.
4. Should disaster strikeBe preparedCentral Health Bureau Directorate,
General of Health Services, Government of India.
5. Swasth Hind, Annual Report 1999-2000.
Appendix 435
Appendix
GOALS TO BE ACHIEVED BY 2000-2015

Year Goals to be achieved
2003 : Enactment of legislation for regulating minimum
standard in Clinical Establishment/Medical Institutions
2005 : Eradicate poliomyelitis and yaws
: Eliminate leprosy
: Establish an integrated system of surveillance, National
Health Accounts and Health Statistics
: Increase State Sector Health spending from 5.5 to 7
percent of the budget
: One percent of the total health budget for Medical
Research
: Decentralization of implementation of public health
programs.
2007 : Achieve zero level growth of HIV/AIDS
2010 : Eliminate kala-azar
: Reduce Mortality by 50 percent on account of TB, Malaria
and other Vector and Water-borne diseases
: Reduce prevalence of blindness to 0.5 percent
: Reduce IMR to 30/1000 And MMR to 100/Lakh
: Increase utilization of public health facilities from current
level of <20 to >75 percent
: Increase health expenditure by government from the
existing 0.9 to 2.0 percent of GDP.
: Two percent of the total health budget for Medical Research
: Increase share of Central grants to constitute at least 25
percent of total health spending
: Further increase of State Sector Health spending to eight
percent
2015 : Eliminate lymphatic filariasis
THEMES OF THE WORLD NO TOBACCO DAYS

A World No Smoking Day, April 7, 1988
World No Tobacco Day, May 31
On 31 May of each year, WHO celebrates World No Tobacco Day,
highlighting the health risks associated with tobacco use and advocating
for effective policies to reduce consumption. Tobacco use is the second
cause of death globally (after Hypertension) and is currently responsible
for killing one in 10 adults worldwide.
The World Health Assembly created World No Tobacco Day in 1987
to draw global attention to the tobacco epidemic and its lethal effects. It
provides an opportunity to highlight specific tobacco control messages
and to promote adherence to the WHO framework convention on tobacco
control. Tobacco use is the number one preventable epidemic the health
community faces.
Year Themes
1988 : Tobacco or Healthchoose health
1989 : Women and tobaccothe female smokerat added risk
1990 : Childhood and youth without tobaccogrowing up without
tobacco
1991 : Public places and transportbetter be tobacco free
1992 : Tobacco free workplacessafer and healthier
1993 : Health servicesour windows to a tobacco-free world
1994 : Media and tobaccoget the message across
1995 : Tobacco costs more than you think
1996 : Sport and art without tobaccoplay it tobacco free
1997 : United for a tobacco-free world
1998 : Growing up without tobacco
1999 : Leave the pack behind
2000 : Tobacco kills, dont be duped
2001 : Second-hand smoke kills
2002 : Tobacco-free sports
2003 : Tobacco-free film, tobacco free fashion
2004 : Tobacco and poverty, a vicious circle
2005 : Health professionals against tobacco
2006 : Tobaccodeadly in any form or disguise
2007 : Smoke free inside
2008 : Tobacco-free youth
2009 : Tobacco health warnings
2010 : Gender and tobacco with an emphasis on marketing to women
Appendix 437
World Diabetes Day

In recent years, World Diabetes Day has focused particularly on raising
awareness of the complications of diabetes affecting the heart, eyes, kidneys,
and feet.
The following themes have been addressed since World Diabetes Day
began in 1991:
1991 : Diabetes Goes Public
1992 : DiabetesA Problem of All Ages in All Countries
1993 : Growing up with Diabetes
1994 : Diabetes and Growing Older
1995 : The Price of Ignorance
1996 : Insulin for Life!
1997 : Global AwarenessOur Key to a Better Life
1998 : Diabetes and Human Rights
1999 : The Costs of Diabetes
2000 : Diabetes and Lifestyle in the New Millennium
2001 : Diabetes and Cardiovascular Disease
2002 : Your Eyes and Diabetes
2003 : Diabetes and Kidneys
2004 : Diabetes and Obesity
2005 : Diabetes and Foot Care
2006 : Diabetes and the Disadvantaged and Vulnerable
2007 : Diabetes in Children and Adolescents
20092013 : Diabetes Education and Prevention
INTERNATIONAL DECADES
20112020 : Decade of Action for Road Safety.
20082017 : Second United Nations Decade for the Eradication of
Poverty.
20062016 : Decade of Recovery and Sustainable Development of the
Affected Regions (third decade after the Chernobyl
disaster).
20052015 : International Decade for Action, Water for Life.
20052014 : United Nations Decade of Education for Sustainable
Development.
Second International Decade of the Worlds Indigenous
People.
20032012 : United Nations Literacy DecadeEducation for All.
20012010 : International Decade for a Culture of Peace and Non-violence
for the Children of the World.
Decade to Roll Back Malaria in Developing Countries,
Particularly in Africa.
Second International Decade for the Eradication of

Colonialism.
19972006 : Decade for the Eradication for Poverty.
19952004 : Decade for Human Rights Education.
19942004 : Decade of the Worlds Indigenous People.
19932003 : Third Decade to Combat Racism and Racial Discrimination.
19912000 : Second Industrial Development Decade for Africa.
Second Transport and Communications Decade in Africa.
United Nations Decade Against Drug Abuse.
Fourth United Nations Development Decade.
19902000 : International Decade for the Eradification of Colonialism.
19901999 : United Nations Decade of International Law.
: International Decade for Natural Disaster Reduction.
1990s : Third Disarmament Decade.
19881997 : World Decade for Cultural Development.
19831993 : Second Decade to Combat Racism and Racial Discrimination.
19831992 : United Nations Decade for Disabled Persons.
19811990 : International Drinking Water Supply and Sanitation Decade.
Third United Nations Development Decade.
19801990 : Second Disarmament Decade.
1980S : Industrial Development Decade for Africa.
19781988 : Transport and Communications Decade for Africa.
19761985 : United Nations Decade for WomenEquality, Development
and Peace.
19731983 : Decade to Combat Racism and Racial Discrimination.
19711980 : Second United Nations Development Decade.
1970s : Disarmament Decade.
19601970 : United Nations Development Decade.
IMPORTANT ACTS RELATED TO HEALTH

Acts
The Indian Medical Council Act, 1956 and Regulations, 2002
The Indian Nursing Council Act, 1947
The Dentists Act, 1948
The Pharmacy Act, 1948
The Rehabilitation Council of India Act, 1992
The Indian Medicine Central Council Act, 1970
The Homeopathy Central Council Act, 1973
The Consumer Protection Act (CPA), 1986
The Registration of Births and Deaths Act, 1969
The Epidemic Diseases Act, 1897
The Transplantation of Human Organ Act, 1994
Appendix 439
The Prevention of Food Adulteration Act, 1954

The International Health Regulation
The Medical Termination of Pregnancy (MTP) Act, 1971
The Maternity Benefit Act, 1961
The Dowry Probihition Act, 1961
The Immoral Traffic (Prevention) Act, 1956
The Prenatal Diagnostic Techniques (Regulation and Prevention of
Misuse) Act, 1994
The Infant Milk Substitutes, Feeding Bottlers and Infant Foods
(Regulation of Production, Supply and Distribution) Act, 1992
The Juvenile Justice (Care and Prevention of Children) Act, 2001
The Child Labor (Prohibition and Regulation) Act, 1986
The Child Marriage Restraint Act, 1929
The Persons with Disabilities (Equal Opportunity, Protection of Rights
and Full Participation) Act, 1995
The Mental Health Act, 1987
The SCs and the STs (Prevention of Atrocities) Act, 1989
The Narcotic Drugs and Psychotropic Substances Act, 1985
The Drugs and Cosmetics Act, 1940
The Drugs (Control) Act, 1948
The Drugs and Magic Remedies (Objectionable Adverstiments) Act, 1954
The Minimum Wages Act, 1948
The Dangerous Machine (Regulation) Act, 1983
The Plantation Labor, Act, 1951
The Factories Act, 1948
The Mines Act, 1952
The Employees State Insurance (ESI) Act, 1948
The Workmens Compensation Act, 1923
The Bonded Labor System (Abolition Act)
The Environment (Protection) Act, 1986
The Biomedical Waste (Management and Handling) Rules, 1998
The Municipal Solid Waste (Management and Handling) Rules, 2000
The Hazardous Waste (Management and Handling) Rules,1989
The National Environmental Tribunal Act, 1995
The Air (Prevention and Control of Pollution) Act, 1981
The Water (Prevention and Control of Pollution) Act, 1974
The Insecticides Act, 1988
The Motor Vehicles Act, 1988
Red Cross Society Act, 1936
YEARS OF LAUNCHING NATIONAL HEALTH PROGRAMS
National program Year

Sexual Transmitted Diseases Program 1949
BCG Vaccination Program 1951
Community Development Program 1952
National Malaria Control Program 1953
National Family Planning Program 1953
Contributory Health Service Scheme 1954
National Water Supply and Sanitation Program 1954
National Leprosy Control Program 1955
National Filaria Control Program 1955
National Malaria Eradication Program 1958
National Small Pox Eradication Program 1962
School Health Program 1962
National Goiter Control Program 1962
District Tuberculosis Program 1962
Applied Nutritional Program 1963
National Trachoma Control Program 1963
Contributory Health Services renamed as 1963
Central Government Health Scheme
Expanded Family Planning Program 1963
National Trachoma Control Program 1968
All India Hospital (Postpartum) PP Program 1969
Accelerated Rural Water Supply Program 1972
National Program of Minimum Needs 1973
National Program for Prevention of
Visual Impairment and Control of Blindness 1976
Rural Health Scheme 1977
Re-oriented Medical Education (ROME) 1977
Modified Plan of Operation (MPO) 1977
Expanded Program on Immunization (EPI) 1978
National Guineaworm Eradication Program 1979
National Mental Health Program 1982
National Leprosy Eradication Program 1983
National Health Policy 1983
Universal Immunization Program (UIP) 1985
New 20 Point Program 1987
National Diabetes Control Program 1987
National AIDS Control Program 1987
Blood Safety Program 1989
Child Survival and Safe Motherhood Program 1992
Reproductive and Child Health Program 1994
Integrated Disease Surveillance Project (IDSP) 2004
Contd...
Appendix 441
Contd...
National program Year
Reproductive and Child Health Program II (RCH II) 2005
Integrated Management of Childhood Illness (IMCI) 2007-2010
Integrated Management of Neonatal and
Childhood Illness 2010
National Rural Health Mission 2005-2012
National Urban Health Mission 2008-2012
WORLD HEALTH DAY
What is the World Health Day?

The seventh of April each year is celebrated as the World Health Day
and it marks the date 1948 when sufficient countries had ratified their
signature to bring the Constitution of the World Health Organization
into force. Ever since 1950, a theme related to international public health
has been chosen for the World Health Day, with an appropriate slogan.
Thus in 1955, the slogan was Clean Water Means Better Health. In
1962, Preserve SightPrevent Blindness and in 1980, Smoking Health
the Choice is Yours.
All over the world, governments, WHO national commities, United
Nations association and Nongovernmental Organizations help to arrange
events related to the theme. Over the years, the World Health Day events
have attracted more and more coverage by mediawhether newspapers
or radio and television. And the impetus does cease when the day is
overthe them is regarded as valid for the rest of the year.
LIST OF WORLD HEALTH DAY THEMES

1950 : Know Your Own Health Services
1951 : Healthy for Your Child and the Worlds Children
1952 : Healthy Surrounding Make Healthy people
1953 : Health is Wealth
1954 : The Nurse, Pioneer of Health
1955 : Clean Water Means Better Health
1956 : Destroy, Disease Carrying Insects
1957 : Food for Health
1958 : Ten Years of Health Progress
1959 : Mental Illness and Mental Health in the World Today
1960 : Malaria EradicationA Word Challenge
1961 : Accidents need not Happen
1962 : Preserve SightPrevent Blindness
1963 : Hunger, Disease of Millions
1964 : No Truce for Tuberculosis
1965 : SmallpoxConstant Alert

1966 : Man and His Cities
1967 : Partners in Health
1968 : Health in the World of Tomorrow
1969 : Health, Labor and Productivity
1970 : Early Detection of Cancer Saves Lives
1971 : A Full Life Despite Diabetes
1972 : Your Heart is Your Health
1973 : Health Begins at Home
1974 : Better Food for a Healthier World
1975 : SmallpoxPoint of No Return
1976 : Foresight Prevent Blindness
1977 : Immunize and Protect your Child
1978 : Down with High Blood Pressure
1979 : A Healthy Child, A Sure Future
1980 : Smoking or HealthThe Choice is Yours
1981 : Health for All by the Year 2000
1982 : Add Life to Years
1983 : Health for All by the Year 2000The Count down has Begun
1984 : Childrens HealthTomorrows Wealth
1985 : Healthy YouthOur Best Resource
1986 : Healthy LivingEveryone a Winner
1987 : ImmunizationA Change for Every Child
1988 : Health for AllAll for Health
1989 : Let Us Talk Health
1990 : Our planet, our healththink globally act locally
1991 : Should disaster strikeBe prepared
1992 : Heart beatThe rhythm of health
1993 : Handle Life with CarePrevent Violence and Negligence.
1994 : Oral Health for a Healthy Living
1995 : Target 2000A World without Polio
1996 : Healthy City for Better Living
1997 : Emerging DiseasesGlobal alert, Global response
1998 : Pregnancy is Precious Let us make it safe
1999 : Active Ageing Makes Difference
2000 : Safe blood starts with me, blood saves life.
2001 : STOP Exclusion dare to care
2002 : Move for Health
2003 : Shape the Future of LifeHealthy Environments for Children.
2004 : Road Safety.
2005 : Make every mother and child count.
2006 : Working together for health.
Appendix 443
2007 : International Health Security.

2008 : Protecting health from the adverse effects of climate change.
2009 : Save lives, Make Hospitals Safe in Emergencies.
2010 : 1000 cities, 1000 lives.
IMPORTANT INTERNATIONAL EVENTS AND DAYS

9th January Cancer Day
30th January Anti-Leprosy Day
1st February Deaf and Dumb Day
8th March International Womens Day
15th March World Consumer Rights Day + World Disabled Day
16th March Measles Day
20th March World Forestry Day
24th March World TB Day
7th April World Health Day
26th April Anniversary of Chernobyl disaster
30th April Child Labor Day
1st May World Labor Day
8th May World Red Cross Day
12th May Red Cross Day
13th May Mothers Day
24th May Dr Olle Hansson Day
31st May World No Tobacco Day
5th June World Environment Day
26th June International Day against Drug Abuse and Illicit
Trafficking
1st July Doctors Day (India)
1st August World Breastfeeding Day World breastfeeding week
5th August World Breastfeeding Practice Day
6th August Hiroshima Day
9th August Nagasaki Day
20th August World Mosquito Day
1st October World Voluntary Blood Donation Day
1-7th September National Nutrition Week
8th September International Literacy Day
20th September International Peace Day
3rd October Habitat Day
10th October World Mental Health Day
11th October National No Tobacco Day
13th October Anti-National Disaster Day
14th October World Standards Day
16th October World Food Day
24th October United Nations Day

15th November World Diabetes Day
18th November World Epilepsy Day
1st December International Pollution and Prevention Day +
World AIDS Day
2nd December National Pollution and Prevention Day
3rd December Bhopal Gas Tragedy Day
8th December National Day for the Mentally Retarded
10th December World Human Rights Day
11th December UNICEF Day.
POLICIES
National Policies Related to Health
1. National Health Policy 2002
2. National Population Policy 2000
3. National AIDS Prevention and Control Policy 2002
4. National Blood Policy 2002
5. National Policy for the Empowerment of Women (2001)
6. National Policiy and Charter for Children Draft
7. National Policy for Old Person 1999
8. National Nutrition Policy 1993
9. National Health Research Policy Draft
10. National Policy on Education
11. National Water Policy
12. National Conservation Strategy and Policy Statement on Environment
and Development 1992
13. Census of India 2001.
ACRONYMS
AFP Acute Flaccid Paralysis
AIDS Acquired Immunodeficiency Syndrome
ANM Auxiliary Nurse-Midwife
ARI Acute Respiratory Infection
BFHI Baby Friendly Hospital Initiatives
CBO Community Based Organization
CBR Crude Birth Rate
CHC Community Health Center
CIDA Canadian International Development Agency
CMO Chief Medical Officer
CPA Consumer Protection Act
CPR Couple Protection Rate
CSSM Child Survival and Safe Motherhood
DALY Disability Adjusted Life Year Lost
Appendix 445
DGHS Director General of Health Services

DHO/DMO District Health/Medical Officer
DHS Directorate of Health Services
DOTS Directly Observed Therapy Short-course
DPT Diphtheria, Pertussis, and Tetanus Vaccine
EPI Expanded Program on Immunization
FAO Food and Agriculture Organization
FWP Family Welfare Program
GBD Global Burden of Disease
GDP Gross Domestic Product
GNP Gross Net Product
GOI Government of India
HIV Human Immunodeficiency Virus
ICCIDD International Council for Control of Iodine Deficiency
Disorders
ICDS Integrated Child Development Service
IEC Information, Education and Communication
IFA Iron and Folic Acid
ILO International Labor Organization
IMA Indian Medical Association
IMR Infant Mortality Rate
ISM Indian System of Medicine
IUD Intrauterine Device
LHV Lady Health Visitor
MCH Maternal and Child Health
MDR Multi-Drugs Resistance Tuberculosis
MDT Mutli-Drugs Therapy of Leprosy
MMR Maternal Mortality Rate
MOHFW Ministry of Health and Family Welfare
MPW Multipurpose Worker
MS Medical Superintendent
Index
Page numbers followed by f refer to figure and t refer to table
A Arthropods 215
Ascariasis 224
Accredited social health activists 282
treatment 224t
Action plan of MLEC 51, 51t
Aspects of school health service 431
Active and passive immunization 182
Aspergillus flavus 195
Acute flaccid paralysis 171
Assessment of
Adolescent
dehydration 61
friendly health center services 313
energy requirement for family 191
girls scheme 314
nutritional status 190
health 308, 311
obesity 83
Advantages of
Atom bombing of Hiroshima 429
MVA 152
Autoclaving 230
syndromic case management 73
Average weight of vegetables 204
Adverse effects of vaccine 177
Ayurveda system of medicine 302
Aflatoxin 195
AFP case
B
investigation 172
case notification 172 Baby friendly hospital initiative 417
Albert stain 256 Bacteria in milk 253
All India Consumers Price Index 12 Bacterial index 41
Allopathy 307 Bacteriological
Amount of ORS solution 61 examination 40, 253
Ancylostoma duodenale 226 of water 247
treatment 226t quality of drinking water 249t
Anganwadi 421 Bacteriology of
worker 423 milk 253
Angina 78 water 247
Angioneurotic edema 184 Balanced diet 188, 200, 200t
Antibiotics used in treatment of for children 201, 201t
cholera 62t Bar diagram 358
Anti-fertility vaccines 141 BCG 166
Anti-larval measures 220 Benefits of School Health Programs 430
Antileprosy drugs 45t Bhopal gas tragedy 430
Anti-nutritional factors 193 Bleaching powder 232, 271
Anti-rabies vaccine 182 Blind school 409
Antiseptic 228 Body
Antisera 179 mass index 84
Anti-snake venom 184 measurement techniques 124
Arachnida 217 Breastfeeding 132
Arm tapes 128f Brocas index 83
Burden of Chlorhexidine 231

disease 52 Chlorinometer 238
leprosy 33 Chloroscope 238
occupational diseases and injuries 3 Choice of contraceptives 153t
tuberculosis 23t Cholera 56
triggers 322
C Chronic noncommunicable diseases
Calculation of and conditions 2
effective couple protection rate 152 Classification of
expected blood pressure 80t
height of child 132 leprosy 37t
weight of child 131 occupational disorders 332
pediatrics doses 132 PEM 120
Calorie deficiency classification 120 Classifying types of leprosy 43t
Cancer 96 Clinical
registration 97, 98 classification of diabetes mellitus 92
Candidate vaccines 48 features of obesity 85
Carcinoma of Clostridium tetani 261
breast 99 Coefficient of variation 363
lung 100 Cohort cure rate MB/PB 35
Case finding tools 20 Coliform test 249
Categories of biomedical waste 267 Collecting
Causes of and handling
cancer 98 cerebrospinal fluid 326
death 351 stool specimens 327
diarrhea 56, 56t blood for cultures 325
maternal death 101 serum 328
Cell culture vaccine 183 sputum 326
Centering constants 361 stool specimens for
Central Pollution Control Board 272 bacteria 327
Cesarean section rate 355 parasites 326
Cetrimide 232 viruses 327
Characteristics of Collection of waste with source
insecta 216f segregation 270
mosquitoes 218f Color coding and type of container
normal curve 370 for disposal of biomedical wastes
Chemical 277t
disinfection 271 Combined
wastes 265 oral contraceptive 144
Chemoprophylaxis 21 vaccine 178
Chemotherapy 54 Common breastfeeding problems 420
Chickenpox vaccine 185 Communicable disease 2, 16, 17
Chief medical and health officer 318 Community
Child based rehabilitation 339
development project officer 423 health centers 3
survival elements 104 level 291
Childhood illnesses 335 Completion of treatment and cure 46
Chi-square test 371 Complex media 257
Index 449
Complicated manifestations of Crustacea 217

disease 187 Cubic space 11
Complications of myocardial Cyclops 224
infarction 78
Components of D
IMNCI in India 335 Deaf and dumb school 410
RCH 103 Death rate 353
Urban Health Mission 293 Definition of
Composition of
infection 16
coordination committee 415t
RCH 103
DPT vaccines 179
statistics 356
Conceptual framework of safe
Deformities occurring in leprosy 43t
motherhood 102
Delivery of
Concurrent disinfection 229
chlorine solution into well 251
Conditioning influences 118
integrated services for maternal
Confirmation of existence of
and child health 416
epidemic 64
Dengue triggers 323
Construction of frequency table 358
Contact period 251 Department of Obstetrics and
Contraceptive failure rate 134 Gynecology 415
Control measures for Detection of
cyclops 224 coliform bacteria and E. coli 248
houseflies 222 fecal streptococci 250
itch mite 224 Determination of total hardness 246
lice 223 Development of immunity 168
ratflea 224 Diabetes mellitus 92
sandfly 223 Diagram of human body 41f
ticks 221 Diarrhea
Control of and dysentery 55
cholera 58 Control Program 56
scabies 68 Diarrheal disease 55
Conventional Control Program 63
contraceptive 134 Dichloro-diphenyl-trichloroethane
regimens 21 235
Convergence of ICDs services 423f Difference in National Tuberculosis
Converging sanitation and hygiene Program and Revised NTCP 29, 29t
under NRHM 284 Diphtheria immunization 178
Coronary heart disease 76 Directly observed therapy short-
Corpulence index 84 course 27
Corynebacterium diphtheriae 261 Disease burden 1
Cresol emulsions 231 Disinfection 62, 228
Criteria for adolescent friendly of sputum 30
health Disposal of
center 313 biodegradable kitchen waste 276
worker 313 feces 300
Crude refuse and excreta 299
birth rate 4 stable litter 301
death rate 4 Dissolve bleaching powder in
phenol 231 water 251
District number of contacts 156

Cancer Control Program 99 requirements of
epidemic investigating team 320 immunization cards 162
epidemiological cell 320 sterilization equipment 159
health syringes and needles 158
laboratory 411 vaccine
plan 284 needs 159
immunization officer 171 requirements 162
infrastructure 432 Ethylene oxide 233
leprosy center 432 Examination for
rehabilitation center 426 Clostridium perfringens 250
project 340 specific pathogens 254
surveillance Expanded program of immunization
committee 319 157
unit 318
tuberculosis F
center 425 Failure of
officer 28 OPV 169
Dosage schedule for MDT 45t three dose regimen 169
DOTS-plus strategy 30 Failure rate of contraceptives 135t
Dr Udanis classification 120 Families of medical importance 220
Dry Family
and wet bulb thermometer 238 cycle 8
camp and kitchen refuse 299 planning
Durhams tubes 249 insurance scheme 148
methods 136
E Fat fold thickness 84
Economic burden of tuberculosis 18 Fermentation 193
Eijkmans test 249 Filariasis 52
Elements of intensified program 52 Final disposal of waste 271
Eligibility criteria for beneficiaries Flag sign 120
under scheme 112 Floor space accepted standard 11
Elimination of Formaldehyde 233
leprosy 51 gas 233
neonatal tetanus 182 Formulation of hypotheses 66
Emergency contraceptives 141 Frequency
Emerging oral contraception 142 polygon 360
Endocrine disorders 83 table 358
Enterobius vermicularis 225 Functions of
treatment 225t District Surveillance Unit 318
Enumerate eligibles 162 PHC 412
Epidemiological and nutritional postpartum unit 414
social security division 347
exercises 399
Epidemiology of malnutrition 122
ESI contribution rates 348
G
Essential indicators for leprosy 34 Gastroenteritis 55
Estimation of Genital ulcers 74
cold chain requirements 160 Geometrical progression method 374
Index 451
Germination 193 Homeopathy 305

Giddiness 183 Hospital waste
Global disposal 266
Leprosy Elimination Program 52 management 264
Strategy of Occupational Health 333 structure 267f
Globe thermometer 240 Houseflies 221
Glutaraldehyde 271 Hypertension 80
Gomezs classification 120
Government rehabilitation services I
340
Immunization 155
Gram stain 255
of pregnant woman 155
Green Light Committee Initiative 32
Immunoglobulin 178
IMNCI
H
plus 338
Handling and strategy in India 335
transportation of respiratory Impact of adolescence 310
specimens 326 Important
transporting facts about contraceptives 153
blood for cultures 325 features of JSY 110
serum 325 international events and days 443
Harwards classification 121 Incinerators 272
Head and chest circumference 129 Indian systems of medicine 302
Headache 183 Infant
Health feeding formula 115, 115t
care
mortality rate 4
indicators 4
Infection 118
infrastructure 3
rates 355
services for beneficiaries under
Influenza vaccines 186
scheme 112
Injectable contraceptives 145, 146t
education 48
Insecticides 234
regarding danger signals 99
Insomnia 183
facilities in India 3t
Integrated
promotion 131
Child Development Scheme 421
status in India 4t
counseling and testing center 408
trust of India 287
disease surveillance 316
Hepatitis B vaccines 186
Hexachlorphane 231 management of neonatal and
Highly infectious wastes 265 childhood illness 337t
High-risk Integration of PPTCT within
infants 117 postnatal MCH services 114
screening 94 Intensive pulse polio immunization
waste 265 175
Histamine test 42, 42t International
Histogram with frequency polygon Death Certificate 377, 377t
360f decades 437
HIV infectious substance symbol 264f
infection 32 Intravenous rehydration 61
vaccine 185 Investigation of epidemic 63, 329
J Maternity
and child health 101
Janani Suraksha Yojana 109 emergency care 102f
Japanese encephalitis triggers 323 Maximum and minimum
Jellyfish classification 121 thermometer 239
Joint family 8 Mean deviation 363
Jones criteria for diagnosis of acute Measles
rheumatic fever 87t mumps and rubella vaccine 186
vaccine 176
K Measurement burden of disease 77
Kata thermometer 240 Measures of
Kishori Shakti Yojna 424 central tendency 361
Kuppuswamys method 12 fertility 374
Kwashiorkor 120, 197t mortality 375
population 374
L variation 362
Laboratory wastes 265 vital statistics 374
Late adolescence 309 Measuring childs height 126f, 127f
Lathyrism 193 Medical methods of abortion 149
Legislative framework 276 Membrane filtration method 249
Lepromatous leprosy 37 Meningococcal vaccines 187
Lepromin test 43 Mental health 88
Leprosy 33 Methods of
Control Programs 48 family planning 136
educational messages 48 social classification 11
Organizations in India 49 study 8
vaccine 185 uterine evacuation 150
Leptospira 262 Methylene blue reduction test 253
Liquid waste 299 Methylisocynate 430
List of World Health Day Themes 441 Microscopic slides 258
Lorentzs formula 84 Midarm circumference 128
Middle adolescence 309
Lymphatic filariasis 53
Mifepristone 149
M Milestones in vaccination 166t
Mineral oil 236
Maintain Misoprostol 149
equipment 165 Mixed vaccines 178
vaccines 164 Mode of transmission 36
Maintenance therapy 61, 61t Modified leprosy elimination
Malaria campaigns 50
triggers 322 Morbidity statistics 376
vaccines 187 Morphological index 42
Mamta scheme 111 Mosquito
Manual vacuum aspiration 150 borne diseases 217, 219
Marasmus 119, 197 control measures 220
Maternal Mukhya sevika 423
and child health 3, 108 Multibacillary rate 35
mortality ratio 4 Multiple tube technique 248
Index 453
Mycobacterium Nurse population ratio 4

leprae 35, 259 Nutrient requirements during
tuberculosis 259 pregnancy 196
Myocardial infarction 78 Nutritional
deficiencies 2
N supplements 422t
National
Cancer Control Program 99 O
Diabetes Control Program 95 Obesity 82
Filaria Control Program 54 Objectives of
Health Policy 55 antenatal visit 107
Immunization health disaster preparedness 428
days 170, 171 NTCP 30
schedule 155, 157, 168 plan 268
information center on disability postnatal care 116
and rehabilitation 341 school health service 431
Leprosy Eradication Program 50 Oral
Mental Health Program 91 glucose tolerance test 94t
polio surveillance unit 173 polio vaccine 168, 173
program for rehabilitation of rehydration therapy 62t
persons with disabilities 427 Orthotolidine arsenite test 252
Rural Health Mission 280
STD Control Program 75 P
Subcommittee of Indian Academy Package of services 422
of Pediatric 121 Passive immunization 181
Surveillance unit 318 Pearl index 153
TB Control Program 29 Pediatric
Tuberculosis Program 425 DOTS 25
Urban Health Mission 292 tuberculosis 25
Neisseria Pellagra 192
gonorrhoeae 261 Per capita
meningitidis 260 income 10
Neuraminidase specific vaccine 186 monthly income 12
Neuroparalysis 184 Percentage of major causes of all deaths
New in developing countries 3t
health financing mechanisms 285 Percutaneous transluminal coronary
initiative in social security 349 angioplasty 78
Newer Perinatal vaccine 185
contraceptives 136 Pesticides 234
vaccines 185 Phosphatase test 254
No scalpel vasectomy 141 Pie diagram 360, 361
Normal Places of natural calamities 427
curve 370, 370f Plague triggers 323
distribution 368 Point prevalence rate 34
with mean zero and standard Polio trigger 322
deviation unity 371t Polyandrous type 7
Notifiable diseases 5 Polygamous type of nuclear family 7
Ponderal index 84 Q
Population strategy 79
Qualities of good contraceptives 134
Postnatal care 116
Quartile deviation 363
Postpartum center 413
Quaternary ammonia compounds 232
Poverty
cycle 122
line 10
R
Prasads Rapid sand filter 245
classification 12t RCH-II and family planning 108
method 11 Recombinant vaccine 186
Precurrent disinfection 229 Recommended dietary allowances for
Pre-exposure prophylaxis 183 Indians 207
Pregnancy rate 136 Rectal swabs 327
Prenatal Recyclable waste
advice 107 Reference index 13t
services 107 Regional rehabilitation training center
Pressurized containers 265 341
Presumptive coliform count 248 Regular periodic survey 317
Prevalence of reproductive tract Rehydration therapy 58
infection 359f Relief of pain 78
Prevention of Reproductive
blindness 410 and Child Health Program 103
parent to child transmission of HIV health elements 104
infection 112 Retirement Programms in Social
Preventive vaccine 185 Security 349t
Primary Rheumatic heart disease 86
health center 3, 412 Risk of tuberculosis 32
urban health center 295 Role of
Primi mothers 420 district within surveillance system
Principles in calculating balanced 319
diet 200 NGOs in mission 289
Probability of larger value of T 369 Panchayati Raj institutions 288
Process of AFP surveillance 173 primary health centers for
Program disability rehabilitation 342
implementation plan 109 state governments under NRHM
management support center 287 288
Proportion of single skin lesion case Routes of
rate 35 administration 167
Proportional bar diagram 358f, 359 transmission 222
Protection against mosquito bites 220 Routine immunization 170
Protein energy malnutrition 119 Rubella vaccine 185, 186
Prototype acute disaster cycle 428f
Puberty S
changes in adolescent 310 Sanitation of camps 297
in girls 310 Scabies 67
Public health importance of ticks 221 Schedule of national immunization
Pulmonary TB 166 157t
Pulse Polio Immunization Program 170 Scheme for adolescent girls 424
Index 455
School Health Sweat test 42, 43t

Program in India 431 Swine flu 350
service 430 Symptoms of ascariasis 225
Sentinal Surveillance under IDSP 317
Seven National Levels Institutes 340 T
Sexually transmitted diseases 69
Table of
Short-course chemotherapy regimens
chi-square 372
22t
unit normal distribution 371
Sickness 17
Ten leading causes of burden of
Siddha system of medicine 303
Side effects of anti-leprosy drugs 46, 46t disease 1t
Skin fold thickness 84 Terminal disinfection 229
Sling psychrometer 241 Test for coliform bacteria 253
Slow sand filter 244 Testing of hypotheses 67
Sodium hypochlorite 232 Tests of statistical significance 364
Split-virus vaccine 186 Tetanus
Spread of diseases 222, 223 spores 233
Stage of toxoid 180
disintegration 9 Themes of World No Tobacco Days
formation 9 436
growth 9 Tick sign 120
Staining procedure for malarial smear Transmission 350
412 Transport medium 324
Standard Treatment for
deviation 363 cancer 99
error of most common STD associated
mean 364 syndromes 73
proportion 367 Treatment of
State ENL reaction 46
Surveillance Unit 318 hypertension 82
tuberculosis officer 28 lower abdominal pain in female 75
Steps for mild dehydration 61
calculation 368 reversal reaction 45
paired T-test 367 severe dehydration 61
Steps in well disinfection 250
urethral discharge 73
Strategies for polio eradication 170
vaginal discharge 74
Strengthening
Treatment plan for rehydration
disease control programs 285
therapy 61t
primary health centers 283
Treponema pallidum 259
Strongyloides stercoralis 227
treatment 227t Trichuris trichiura 225
Structural framework of IDSP 321 treatment 225t
Structure of RNTCP 28 Triggers for syndromic surveillance
Sub-virion vaccine 186 323
Summary of biomedical waste rules 276 Tubercle Bacillus 254
Surveillance Tubercular meningitis 167
medical officer 171 Tuberculosis 18, 198t
of acute flaccid paralysis 171 unit 28
of noncommunicable diseases 332 Turbidity test 254
Types of Varishtha Pension Bima Yojana 349

bacteria in milk 253 Viral transport medium 324
disinfection 229 Virological classification scheme 172
family 7
hospital waste 265 W
media 257 Warm chain 117
non-sporing bacteria 233 Waste disposal strategy 270
PEM 119 Waterlows classification 121
vaccine 167 Weighing procedure 124
vacuum aspiration 151 WHO prototype growth chart 130f
Typhoid fever triggers 322 World
breastfeeding week 419
U diabetes day 437
Unani system of medicine 304 health day 441
Under RCH Program 106 Wuchereria bancrofti 226
Universal Immunization Program 157 treatment 226t
Urban
health delivery model 294 Y
measles campaign 178 Years of launching National Health
Uses of Programs 440
hanging spring balance for Yoga 306
weighing infants 125f
MVA equipment 152 Z
V Ziehl-Neelsen stain 256
Vaccine 166
vial monitoring 176

Essentials of Community Medicine - A Practical Approach PDF

Uploaded by

Copyright:

Available Formats

Essentials of Community Medicine - A Practical Approach PDF

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Essentials of Community Medicine - A Practical Approach PDF

Uploaded by

Copyright:

Available Formats

Contents i

JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD

Jaypee Brothers Medical Publishers (P) Ltd

2012, Jaypee Brothers Medical Publishers

Inquiries for bulk sales may be solicited at: [email protected]

Essentials of Community MedicineA Practical Approach

First Edition: 2004

1. Present Health Status 1-6

4. Communicable Diseases 16-75

5. Noncommunicable Diseases 76-100

6. Maternity and Child Health 101-133

Conceptual Framework of Safe Motherhood 102

Classification of PEM 120

7. Reproductive and Child Health 134-154

Estimation of Requirements of Sterilization Equipment 159

Approximate Weight of Foods Equal to 1 Level Katori (Bowl) of

11. Disinfection 228-233

12. Insecticides and Rodenticides 234-237

13. Environmental Models 238-245

Used for Measuring 240

14. Water Analysis 246-252

15. Bacteriology of Milk 253-254

Staining, Culture Media and Microscopy of Slides

Culture Media 257

17. Hospital Waste Management 264-279

18. National Rural Health Mission (2005-2012) 280-296

Institutional Mechanisms 286

19. Sanitation of Camps 297-301

21. Adolescent Health 308-315

22. Integrated Disease Surveillance Project 2004-2009 316-334

Polio Trigger 322

23. Integrated Management of Neonatal and Childhood Illnesses 335-338

24. Community-Based Rehabilitation 339-345

25. Social Security 346-349

26. Swine Flu 350-352

27. Hospital Statistics 353-355

Table of the Unit Normal Distribution 371

30. Visits 408-434

What is this Program All About? Can it be Simply

CHALLENGES OF 21ST CENTURY

5. Poor level of literacy of the people

CHRONIC NONCOMMUNICABLE DISEASES AND CONDITIONS

of people. In 1992, about 30 percent of babies were born with birth

Recent trends with regard to nutritional status of women and children

MATERNAL AND CHILD HEALTH

Burden of Occupational Diseases and Injuries

Table 1.4: Health status in India

Clinical Diagnosis and Community Diagnosis (Table 1.5)

Clinical diagnosis Community diagnosis

16. Toxic anemia.

Three Generation Family

Familya Dynamic Unit

Stage of formation: This stage begins with marriage.

GENERAL INFORMATION FOR STUDENTS

Floor Space Accepted Standard

and not for individuals. While using this classification it is necessary to

CF = Value AICPI, (Which is variable and it was Rs 741 in July 2009)

Table 3.2: Reference index