Depression Raises Parkinson's Risk, Study Confirms

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Depression Raises Parkinson's Risk, Study Confirms - NBC News http://www.nbcnews.com/health/health-news/depression-raises-par...

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HEALTH MAY 21 2015, 3:01 PM ET

Depression Raises Parkinson's


Risk, Study Conrms
by MAGGIE FOX

Robin Williams brought the potential links between depression and Parkinson's to public attention after his suicide last year.
! Getty Images

People with depression were much more likely to develop Parkinson's disease years later,
Swedish researchers report in a new study that strengthens the theory that depression and
Parkinson's are linked.

This one suggests that the depression comes first, not the other way around, the team at Ume
University in Sweden found.

"We saw this link between depression and Parkinson's disease over a timespan of more than two
decades, so depression may be a very early symptom of Parkinson's disease or a risk factor for
the disease," Peter Nordstrm of Umea University, who led the study, said in a statement.

"DEPRESSION MAY BE A VERY EARLY SYMPTOM OF


PARKINSON'S DISEASE OR A RISK FACTOR FOR THE DISEASE."
The study is very strong because it follows the entire population of Swedes who were over 50
by the end of 2005. Nordstrom's team found more than 140,000 who were diagnosed with
depression between 1987 and 2012. They compared them to similar people who were not
diagnosed with depression.

Then they checked to see who had Parkinson's disease. They could do this because Sweden
has an extensive database on the health of its citizens.

Over 26 years, 1,485 of the people had been diagnosed with Parkinson's, the % & + (
team reports in the journal Neurology. About 1 percent of those who had depression at some
point went on to develop Parkinson's, while just 0.4 percent of the population that did not ever <Links to
have depression were diagnosed. PDF fact sheet
This does not necessarily mean that depression causes Parkinson's, says James Beck, vice
on depression
president of scientific affairs at the U.S. Parkinson's Disease Foundation, who was not involved in and PD.
the study.

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Depression Raises Parkinson's Risk, Study Confirms - NBC News http://www.nbcnews.com/health/health-news/depression-raises-par...

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"I think the bigger message is that depression and Parkinson's disease really go hand in hand," Online: 27,277,095
Beck told NBC News. "We have known that before, but this is a very large study."

"THERE IS SOMETHING ABOUT THE PARKINSON'S DISEASE


BRAIN THAT LEADS TO DEPRESSION."
Beck says people who are depressed may need to pay close attention if they develop tremor or
other early symptoms of Parkinson's. Most people, he says, wait until symptoms are more
evident before seeking medical help.

The links between depression and Parkinson's hit U.S. headlines last year when comedian Robin
Williams died. His wife said he'd been struggling with both, although an autopsy suggested he
had Lewy body dementia, which can cause Parkinson-like symptoms.

In a recent U.S. study, researchers found about 14 percent of Parkinson's patients screened
positive for depression, versus 6.6 percent of controls who did not have the disease.

Federal statistics show that close to 8 percent of Americans have depression of some kind, but
only about a third of those are getting treated for it. The Parkinson's Disease Foundation
estimates that 7 million to 10 million Americans have the condition, marked by tremor, rigid
muscles and problems with movement. There is no cure, although early treatment can delay the
worst symptoms.

"Understanding how depression occurs still remains a mystery," said Beck. "There is something
about the Parkinson's disease brain that leads to depression."

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