1 Pharma Questions
1 Pharma Questions
1 Pharma Questions
2014
2015
Pearsonvue
Exam of
Pharmacy
-
- Cases -
:
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ceftriaxone +macrolid or doxy
Ceftriaxone plus either a respiratory fuoroquinolone or azithromycin
**
2-drug need dose adjustment in renal failure
a-Impeniem/cilastatin
b-Clindamycin
c-Ceftrisxon
d-Amoxicillin
**
d-Iron
**
4-what lab tests have to done today:
a-Urin analysis
b-Coagulation test
c-Thyroid test
d-Cbc
**
5- patient with ulcerative colitis ttt on cortison and mesalazin must use
what
a-Iron
b-Vit b12
c-Calcium
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B-LH
C-PROGESTERONE
D-progesterone and Lh
**
b- diclofenac
c- chlorpheniramine
b-700 mcg/day
c-1200 mcg/day
d- 900
Note:
non pregnant
pregnant
Lactating
400 mcg/day
600 mcg/day
500 mcg/day
**
9-which drug will be more absorped in prescence of rantidine
a-warfarin
b-aspirin
c-triazolam
d-naproxen
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a-azithromycin
c doxycyclin
b-naproxen
c-Vit k
d-naloxon
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**
16-recommended calcium dose for geriatric
a-800mg
b-600mg
c-500mg
d-1200mg
**
17-recommended vit d3 dose for geriatric
a-200 iu
b-400iu
c-600 iu
d-300iu
600 iu
800 iu
**
b-doxycyclin
c-amoxcillin
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d-cefclor
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**
22 - gray man syndrome caused by :
a-amiodarone(antiarrhytmic drug)
b-amlodipin
c-amiloride
d-propranalol
**
b-doxucyclin
c-cefpodixme
d-amoxcillin
**
Q- Drug induces lupus like syndrome: Hydralazine & Procainamide
**
24-diphenoxylate and loperamide are narcotics or opioid agonists which
are used as :
a-anti-inflammatory
b-anti diarrheal
c-antipyretic
d-anitcholergic
**
25-both of cimetidine(h2blochker) and spironolactone have anti
androgenic effect
**
26- which of the following is the drug of choice for giardiasis
a-propranolol
b-metronidazole(flagyl)
c-thiabendazole
d-mebendazole
**
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b-asthma
c-influenza
**
29-tertiary amine of TCA (tricyclic antidepressant) is
a-Amitriptylline and imipramine
b-desipramine and nortriptyline(secondry antidep.)
**
30-GRAIN= .065gram or 65mg
**
31-cyclosporin used as immunosuppressant after organ transplantation to
reduce possibility of rejection of new organ by immune system
**
32-Respiratory acidosis is caused by
a-CO2 retention
b-O2 retntion
c-N retention
**
33- the main side effect of alpha antagonist (blocker) as prazosin is
Postural hypotension (orthostatic hypotension)
**
34-morphine cause constipation
**
35-anti cholinergic cause constipation
**
36-narcotic addiction is treated by:
a-methadone
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b-vit.b12
**
b-vecuronium
c-doxacurium
**
41-tyrosine kinase class II receptors are insulin receptors
**
42-drug of choice for pneumonia is pencillins
**
43-mechanism of action of choloroquine(anti malaria ) : choloroquine
bind to heme and prevent it's polymerization to hemozin
**
44-P.C: after meal
P.R.N: as needed
QID=QDS=4times daily
**
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**
47-desmopressin used in treatment of : nocturnal enuresis and diabetes
insipidus
**
48-mechanism of action of clomiphene :
Inhibit negative feed back of estrogen
**
49-rifampicin is used in : leprosy &tuberculosis
**
50-morphine act on mu receptors
**
51-after drug metabolism the drug become
a-polar
b-nonpolar
c-active
d-nonactive
**
52-antidote of iron toxicity: desferroxamine
**
53-digoxin shouldn't be taken with renal failure
**
54-amphotericin-b is
a- parentral anti fungal
b-oral
c-subc
**
55-drug of choice for pseudomonal aeruginosa is:
a-meropenem
b-penicilln
c-imepeinm
Page 9
**
56-digoxin toxicity increased with
hypokalemia or hypomagnesmia or renal failure all of them
**
57- lorazepam is hypnotic at dose of 4mg
**
58-antibiotic which cause yellow teeth tetracycline
**
59-long acting) insulin is :
a-NPH
b-glargine(
c-regular
b-methadone
**
b-antiviral
c-influenza vaccine
**
**
a-epinephrine ( used as broncho dilator)
b-cimetidine
c-reserpine
**
66- loop diuretics (furosemide) cause ototoxicity ( deafness)
**
67-drug need serum creatinine to be monitored
a-gentamycin (aminoglycoside)
b-cefourixme
c-doxycycline
**
68-drug need serum level monitoring with quinidine :digoxin
**
69-magnesium sulphate( antiacid) has cathartic side effect so used as
laxative
**
70-beta2 blocker and aspirin are contraindicated with
a-asthma
b-hypertention
c-diabetes
**
(zyrtec (cetirizine)
**
b-amiolride
c-naloxone
**
84-medication cause long Qr and bradycardia:
Qr.....propranolol
**
85-clonidine and methyldopa are alpha 2 agonists
**
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B-thiazide
**
b-Bupivcaine
c-mepvicaine
**
92-if aspirin taken with warfarin or heparin lead to bleeding
**
93-drug of choice for tape worms : praziquantel or neclosamide
**
94-deltiazem used in hypertension to inhibit calcium influx
**
95-mechanism of aminglycoside: protein synthesis inhibitor
**
96-antacid is used in heart burn to neutralize acidity
**
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b-meningitis
c-measles
**
102-antipsychotic cause agranulocytosis: clozapine atypical
**
103- metformin and metronidazol cause : metallic taste
Captopril cause loss of taste
**
104-treatment of myasthenia gravis( ) by pyridostigmine or
neostigmine
**
105-influenza vaccine contraindicated in (0-6) months baby
**
106-drug should be used with precaution in asthma :b2 antagonist
**
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b-1200
c-200
d-300
**
Dose in iron defecieny anaemia is:A- 100mg tid
B- 212,5 mg tid
C- 275 mg tid
4- 325 mg bid
If in the question elemental iron: the recommended oral daily dose for
the treatment of iron deficiency in adults is in the range of 150 to
200mg/day of elemental iron"50-65 mg 3 times per day.
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d-propranolol
b-mmr vaccine
c- dap vaccine
**
124- which of the following drug taken by inhalation
a-Amyl nitrite or halothane
**
125-what is cytochrome subtype responsible for drug interaction between
omeprazol and clopidegrol :CYP2C19
**
126- digoxin mechanism : +ve inotropic effect
**
127- grinding of solid or powder in liquid or ointment is
a-LEVIGATION
c-disintegration
b-grinding
d-reduction
**
b- cathartics
c- activated charcoal
**
b-thiabendazole
c-neclosamide
b- reserpine
d-vasopressin
**
B-SILVER
C- COPPER
**
b-quinine
c-chloroguanide
**
140- To increase duration of lidocaine in anasethia
a-propranolol
b-succinyl chline
c-epinephrine
**
141- Which organism is the cause of travelers diarrhea :E.coli
**
142- Anticancer from plant alkaloids origin:
A-Cisplatin
B- Cyclophosphamide
C-Etoposide
B-Implantation
C-Follicle develpment
**
a- cardiac toxicity
c- postural hypotension
b- nephrotoxicity
d- arrhythmia
**
b-50 mg/day
c-90mg/day
d-200 mg/day
A-polar
insoluble
b- non polar
c- Lipophilic
d-
**
148- which drug may used as anti-spasmodic
a-reserpine
propranolo
c-baclofen
b-amphetamine
d-
**
149- desmopressine used in :- nocturnal enuresis & diabetes insipidus
**
150- Coal tar uses in (psoriasis)
**
151- Cephalosporin act as:a-Inhibitors of cell membrane function
synthesis
c-Inhibitors of protein synthesis
synthesis
**
152- ISONIAZIDE used in Tuberculosis
**
153- The latin abbreviation for(state):- Immediately
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**
154- Dopamine is used in cardiac shock as:a- decrease C.O.P.
b- Don't induce preiphral vasoconistriction
c- Increase .force of contraction
d- constrict selective dilate renal & mesenteric
**
155- Which of following is the drug of choice for treatment of all forms of
Schistosomiasis?
a-Praziquantel
Thiabendazole
b-Mebendazole
c-Niclosamide
d-
**
156-- which of these have interinsc sympathomemtices effect:
a-labetlol
b-timlol
c-nadolol
d-pindolol
**
157- amphetamine pharmacological action:
a- direct acting adrenergic agonist.
b-direct acting adrenergic
antagonist.
c- indirect acting adrenergic agonist.
d-muscarinic acting agonist
**
158-live attenuated vaccine:
a-measless,mumbs & rubella (MMR)
diphtheria
b-influenza
c-
**
159-sevelamer used in patients with chronic kidney disease for
a-Hypermagnesmia
Hyperphosphatemia
b-Hyperkalemia
c-
**
160- mechanism of action of clomiphene
b-cardiac toxicity
c-nephrotoxicity(kidney
**
162-which of the following diabetic drugs approved by fda for pediatric
use
a-pioglitazone
rastinone
b-metformin
c-glimeperide
d-
**
163- Pharmacy and therapeutic committee
a-storage of drug
c-expiration of drug
b-adverse effect
d-maintain of formulary of drug
**
b- potency
c- indication
**
b-tamsulin
c-bethanecol
d-defranecin
**
166-which of the following used to deal with adverse drug effects
a-pharmacokinetics
c-pharmacoeconomics(cost)
b-pharmacovigilance(safty)
d-pharmacognosy(plants)
**
a- teriparatide
c-alendronate
b- calcium gloconate
d-non of the above
**
b) consensus statement
d) meta analysis
b-pioglitazone
c-metformin
**
171-which vaccine should be taken every year
a-influenza vaccine
b-vzv
c-tetanus vaccine
**
172-estrogen antagonist and used first line in treatment of breast cancer
A-anastrazole
B -tamoxifen
**
173-drug of choice for giardiasis and amoeba
a-niclosamide
c-primaquin
b-metronidazole
d-mebendazole
**
(Menaquinone; K2;)
(Menadione; K3)
**
175-toxidrome is
a-over poison induced syndrome
b-steps involved in treat of toxicity
c-symptoms and signs due to toxicity
**
176-a geriatric patient with osteoarthritis mild pain in hip . he has
hypertension and coronary artery disease what is the best drug for pain
a-glucosamine
c-ibubrofen
b-paracetamol(acetaminophen)
d-aspirin
**
b-2phases
c-3phases
d-4phases
**
178-prescription label should contain
a-patient telephone
c-patient name
b-physician telephone
d-physician name
**
b-tdap
c-dtp
**
181-Thimerosal (mercury)containing vaccine may cause: autism
**
182- Unit dose cassettes in hospital has doses of:
a-day
b-week
c- next change
d-single dose
**
183-septic shock patient with normal sodium value with high potassium
and creatine the treatment is : dopamine
- Cardiac shock = Dopamine
- Anaphylactic shock= Epinephrine
- Septic shock= 1.intravenous fluid (normal saline) first
2.Dopamine
Septic shock in this question with normal sodium level and renal failure
(kidney injury)= Dopamine
**
184- Nitro glycrin side effect is:a-headache
b-bradycardia
c-hypotension
**
185- loperamide act as:
a- Opioid antagonist anti-diarrheal
b- analgesic
c- in parkinsonism
d- opioid agonist anti-diarrheal
**
186- florouracil is Pyrimidine derivative
**
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b-pregnant
**
b) urokinase
d) Abciximab
**
b) anti_hypertensive
d) in chemotherapy
**
194.
b-hypertension
c-diabetes
d-
**
197--Drug with high Distribution Volume , What Means :
a-drug has Diffuse distribution
b- localized distribution
c-conc. of drug in plasma is higher than that in tissues
d- conc. of drug in tissues is higher than that in plasma
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Note : Vd= total amount of drug in the body / drug plasma conc
**
198-A fixed dose of drug that follows 1st order elimination depends on ::
a- dose of drug
b- dosing intervals
c- elimination Half-life
to reach STEADT STATE for drug follows 1st order it depends on rate of
elimination
**
199-Kidneyfailure patient with hyperkalemia which of the following
should be used
a-insulin
b-thiazide diuretic
c- calcium carbonate (may use calcium gluconate or calcium carbonate)
d-spironolactone
**
200-the oesophageal ulcer occurred due to: increase gastric secretion
**
201- if a medication error happened , the first person to refer to :
a) patient
b) prescriber
c) medication safety office
**
202-- another definition for a soluble solution : homogenous
**
203- Opioids can be used as:
a- analgesics
c- anti- epileptic
b- anti hypertensive
d- in chemotherapy
**
204- 2 years old child come to clinic for taking hepatitis vaccine , we
know that he took pneumonia vaccine from month ago , so we should :
a- give him the vaccine immediatly
c- wait for 6 months
b-analgesic
c-anticancer
**
b-succinylcholine
c-rocuronim
**
207-which of the following conditions have non preventable adverse
effect ?
a-allergy from amoxicillin with some one is known that hasn't adverse
effect with any drug
b-tachy cardia with some forgot his dose of anti hypertensive drug and
took 3pills
c-half dose of acetaminophen will cause fever
**
208-which of the foolowing is contraindicated with angina
a-aspirin
b-isosorbide
c-metoprolol
d-vassopresin
b-alpha antagonist
c- adrenergic agonist
**
210-usual daily dose of phenytoin
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a-100-300mg
b-15 mg
c-6mg
d-3mg
**
211-mechanism of action of dantrolene :
(direct acting)
a-cause skeletal muscle relexant bybinding to the ryanodine receptor
decreasing intracellular calcium concentration
**
212-ergot alkaloid used in
a-Uterine stimulant
b-hyperlipidemia
c-hyperuricemia
**
213-perphenazin used in (anti psychotic)
a- nausea and vomiting
b-gout
**
b-hypertension
c- arrhythmia
**
216-Which of the following used as anti estrogen when used cause
abortion
a-anastrozole
b-tamoxifen
**
b-sodium chloride
d-potassium
**
b-12 months
c-24 months
d-36 months
**
219-You should keep the prescription of narcotics in the pharmacy for
a- two year
years
b- three years
c- four years
d- five
**
220-Release from bacteria during The growth :
a- Endotoxin
b- Cytotoxin
c-Exotoxin
**
221-drug dependence means: addiction
**
222-The following is related to dependence :
a- increasing dose of drug to obtain the same effect
b- increasing the dose of drug but no withdrawal symptoms
c- increasing the dose of drug associated with withdrawal symptoms if
sudden decrease
d- decreasing dose to obtain the same effect gradually
**
223-The following is related to tolerance :
a- increasing dose of drug to obtain the same effect
b- increasing the dose of drug but no withdrawal symptoms
c- increasing the dose of drug associated with withdrawal symptoms if
sudden decrease
d- decreasing dose to obtain the same effect gradually
**
So
Simvastatin
**
227- Dont give vaccines to:
A-hypertension patient
b-patients with kidney disease
c- Patients with CD4 < 200
live vaccine c/i with which of the following
choose pt who have CDcount less than 200
**
228- anti diabetic drug used in pregnancy
A-rosiglitazone
b- Metformin
c-glargine Glargine is long acting insulin
NOTE:
Metformin is category B in pregnancy & can be used.
Insulin is the drug of choice in gestational diabetes (diabetic
pregnant) but glargine (long acting insulin) is category C in
pregnancy.
If there is no insulin in choices choose metformin NOT glargine.
**
229- drug for esophageal reflux Pantoprazole
**
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B-prescriber telephone
D- Pharmacist name
B-nitrofurantoin
D-sulphamethoxazole
N.B:
Nitrofurantoin & Sulpha drugs cannot be used in GDPD deficiency
patients because it has high risk to them.
**
249- Pregnant woman has UTI (Urinary Tract Infection) which is the drug
of
choice to treat her UTI :
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a-ciprofloxacin
nitrofurantoin
b-tetracyclin
c-sulphamethoxizole
d-
**
251-drug that makes urine red
A- Rifampicin
b- nitrofurantoin (brown)
**
A-Drugs that make urine red are:
phenazopyridine
senna laxative
rifampicin
Doxorubicin
B-Drugs that make urine brown are
metronidazole dark urine
nitrofuration brown colour
**
252- which antibiotic more likely to cause diarrhea
a-ciprofloxacin
b-doxycycline
c-penicillin
Augmentin
d-
d- muscle
e-
**
254- If a drug has the same active ingredient like other drug but not
contain the same inactive ingredient this mean-:
a- Bioequivalent
c- pharmaceutical alternative
b-pharmaceutical equivalent
d- A and B
**
**
256- To know the severity of immunodeffiecency in HIV
a-ESR
c-WBC COUNt
b-LEUCOCYTE COUNT
d- CD4 count
**
.b. bureaucratic.
.d. benevolent.
**
a. in the refrigerator.
b. in a plastic vial with a childproof cap.
c. with the original cotton.
d. in an amber glass bottle with a metal cap.
e. in a warm, dry place
**
260- Following the ethical principle of nonmaleficence requires that
pharmacists:
a. respect the rights of patients to make choices.
b. do good to patients, placing the benefit of the patient above all else.
c. avoid, remove or prevent harm from people.
d. act with fairness, allowing people access to pharmacy care.
e. act with honesty, without deception.
**
261- Hydroxyurea is antineoplastic drug
**
262- Which one of the following is taken orally
a-Estrogen
c- Estrogen malate
b- Estrogen gluconate
d- all of the above
**
**
264- Plasma conc. Of drug in all body is
a- rate of absorption
c- rate of binding
b- rate of distribution
d- therapeutic volume
**
Q.You should keep the prescription of narcotics in the pharmacy for
a- two year
b- three years
c- four years
d- five years
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36
**
265-The following statements are wrong about domperidone except
a- anti-emetic without CNS effect
b- anticoagulant
c- anti-emetic with sever CNS effect
d- non of the above
**
266- Pka for normal water in room temperature :
A- 7
B- 14
C- 7^10
D- 10^14
**
267- drug make urine red other than rifampicin?
phenazopyridine (Pyridium), and laxatives containing senna
**
268-syncop may occure with the 1st dose of the folowing
c-prazosin
d-reserpin
a-digoxin
b-salbutamol
**
269 -which one is more effective agaienst in traveller diarrhea:
a-amoxiciilin
c-sulphamethoxasol
b-ciprofloxacin
d-erythromycin
b)Reserpine
c)Methyldopa
d)Atenolol
**
271- the action of digoxin can reduced with
a- antacid
d-hypothirodism
b-verapamil
e-hyperthyrodism
c-hypokalemia
**
273- digitalis arrhythmia can be treated with
a-lidocain
b-quinidin
c-procainamide
d-propranolol
Digitalis arrhythmia treatment drugs RESPECTIVILY :
1.lidocaine
2. phenytoin
3. procainamide
4. propranolol
**
274- which one used in ventricular arrhthmia with heart block Phynetoin
**
275-which one is antiarrythmic class 1A
a-phynetoin
b-disopyramide
c-propranolol
d-verapamil
**
276-- Anticancer derived from plant origin NOT venca_
Etoposide
- anti cancer derived from venca is_ Vincristine
Plant origin ... Etoposide
Vinca Plant ... Vincristine
**
277-which one used to trigeminal neuralgia
tegretol(Carbamazepine)
**
278- process require CYP450 :
a)Oxidation
c)Glucoronidation
b)Hydrolysis
d)Deamination
**
b) Physical property
d) Irreversible
e) A + d
**
280- about steady state concentration during IV administration
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b- atropine
d-b&c
**
282-one of following is not alpha 2 agonist :
a) Clonidine((alpha 2 agonist ))
b) Alpha methyl noradrenaline
c) Guanfacine
d) Guanabenz
e) Guanethidine
- about side effect of quinidine :
Cinchonism
Q- volatile substance given by inhalation:
a) Halothane**
**
283-about digitoxin , which is false :
a) Oral bioavaiability 100%
b) Protein binding 95%
c) Half life is 7 days
d) Mainly hepatic metabolism by microsomal
N.B: oral bioavailability of digitoxin 90% (practically we call its
completely absorbed) and 70% for digoxin
**
284-to compare between 2 drugs use:
a) Physical appearance
b) Weightif comparing bioequivalency))
c) Pharmacokinetic parametersif effect
d) Pharmacodynamic parameter
e) Taste
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N.B: c and d are true .. in the exam must give one of them not both
**
285- about sid effect of oral contraceptive except :
a) Depressoin
b) Hypertension
c)constipation
**
286- drug used in ventricular arrhythmia :
a) Phynetoin
Verapamil
b) Quinidine
c) Procainamide
d)
**
a- antibiotic
c - anti platlet
antihistaminic
b- anticoagulant
d- ) non sedating
**
296- all these drugs are anti metabolite execept
Cisplatin
**
297- about digioxin what is not true ?
taken only orally
**
a- Pirbuterol
b- Salmetrol
c- Terbutaline
d- Albuterol
**
302-Which of the following drugs is not a Tricyclic Antidepressant?
a- Trimipramine
b- Maprotiline (tetracyclic)
c- Nortryptiline
**
303- The most common disintergrator in compressed tablets is
a- Dextrose
bitartrate
b- Lactose
c- Starch
d- Potassium
**
304-Which of the following is found in vitamin b12?
a- Magnesium
b- Nickel
c- Iron
d- Cobalt
**
305-Gums are used in tabletting primarily as
a- Disintegrators
c- Lubricants
b- Glidants
d- Binding agents
**
b- angina
d-steroids deficiency
**
307-Ultra-short acting barbiturates are used primarily as
a- Sedatives
c- Anti-parkinsonian agent
b- Hypnotics
d- Preanesthetic agents
**
308-for a 4 year old child, the maximum daily dose of paracetamol is
a- 240mg
b- 480 mg
c- 1 g
d- 2 g
b-fibrinolytic
c-aspirin
d-ACEI
**
310-Which one of the following cannot be dispensed without prescription:
a- Ibuprofen
c- Aspirin
b- Doxycycline
d- Bisacodyl
**
311-The aim in the management of uncomplicated hypertension:
a- > 90\65
180\110
b- > 130\80
c- > 150\95
d- >
**
312- A hospital on formulating drugs, Efficacy, Work overload, and Costs
are taken in concern. A, B, C, D, and E are antifungal drugs available in
the market. All have the same efficacy. The hospital was using drug E for
a period of time. According to the following data which drug is best to be
used by the hospital:
DRUG COST FREQUENCY DURATION
A-3.25 BID 14 DAYS
C-5.5 BID 7 DAYS
313- Solid dosage forms are better than Solution dosage form because:
a- Accurate dose
stable
d- Faster action
b- Easy to handle
c- More
e- a&b and c
**
314- Tolerance is a problem when using Nitroglycerin, which of the
following is true:
a- Tolerance doesn't occur in young patient
b- Over 50 years patient doesn't develop tolerance
c- Dosing schedule may affect tolerance
d- Isosorbide dinitrate doesn't develop tolerance
**
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**
316-indapemide used in
Pulmonary eodema
Essential hypertension
if we have choice both of them this choice is correct or if not have both we
must choice essential hypertension
**
317- one of the followimg not related to heparin
a-prevent blood clotting
b-decrease antithrombine time
c-prevent formation of factor VII
d-used in pulmonary empolie
Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX,X) ,
whereas heparin and related compounds increase the action of
antithrombin on thrombin and factor Xa
**
318-Which not effect of caffiene-:
a)preiphral vasoconistriction
c)dieresis
d)skeletal muscle relaxant
b)cardiac stimulation
e)stimulation of C.N.S
**
319-Hypertonic solutions can be adjusted by:
a-Add Nacl salt to solution
b-add any other salt
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**
320-enteroHepatic recycling depend on all of the following except:
a-Dosage form of the drug
b- Extent of drug passed in feaces
c- extent of drug absorption from stomach
d-gall blader state
**
321-which of the foll. drugs show most multidrug resistance
a)antibiotics
c)a&b
b)anticancer
**
B- non-polar + polar
D- all of the above will be miscible
**
B- Colloidal
D- Polar
**
324- The following properties are similar for both solutions and
suspensions:
A-The components of both solutions and suspensions can be separated
from each
other by physical processes. .
B-Solutions and suspensions are composed of two or more components.
C-Solute in the solutions and suspensions settle out over a period of time.
D-Both A and B
**
325- Concerning COX-2 inhibitor, which is not true ?
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A- they have lower risk gastric adverse reactions than non-selective agents
B- good evidence about their effectiveness in osteoarthritis
C- cardiac toxicity is a recent concern of this class of drugs
D- they are. usually administered once or twice daily
E- combination with non-selective agents provide additional benefit
**
326- In the treatment of the osteoporosis, which of the following is not
correct:
A- alendronate should be taken in the morning 60 min before breakfast
B- calcium and vitamin D are essential
C- hormone replacement therapy (HRT) should be considered in all
postmenopausalpatients with osteoporosis
D- outcome should be assessed with periodic bone density studies
E- raloxifene is selective estrogen modulator that is contraindicated in
DVTpatients
We use HRT when other ttt have failed
**
327- Side effects of albuterol include which of the following?
A- Bradycardia
D- Hypotension
B- Tachycardia
E- Alopecia,
C- Convulsion
**
328-Which of the following side effects is associated with the use of
norepinephrine:
A-Nausea and vomiting.
B- Ischemic damage due to vasoconstriction and tissue hypoxia.
C- Hypoglycemia due to increase insulin reiease.
D- Skin rashes.
E- Headache and constipation.
**because the drug vasoconstriction
**
329- the pharmacological property of amphetamine is:
b-diuresis
d-hyperuricemia
**
b-phenytoin
c- ranitidine
d-
**
333-thiopental is ?
a ) short acting barbiturates
c ) spinal anaesthesia
b ) spiramycin
d ) clarithromycin
**
335- Digoxin action except :a-+ve inotropic
b-shorten refractory period in atrial and ventricular myocardial
c-increase conduction velocity in AV node
d-contraction of myocardial muscle
**
Q-All of the following to decrease the exposure to the radiation except
a-increase the distance from radiation source
b-out from the place of radiation
c-put shelves
e-decrease the activity of radiation person
**
336- Milironin has following except :
a-+ve inotropic
b-vasodilator
c-increase ca intercellular
intercellular
d-phosphodiasterase inhibitor
e-potantiate the effect of CAMP
**
337- Very small molecule(1 part ) soluble in more than 10,000 part of water
a- fairly soluble
b- slightly soluble
C-immiscible
d- miscible
e- insoluble
**
338- Which one of the following cause hypertensive crisis if withdrawn
suddenly
a- Clonodine
b- hydrochlorthiazide
c- b-blocker
d- prazocin
**
339-which one is not effect of Nitroglycerin vasodilation
b- slow heart rate
a- relax of biliay muscle
c- taken sublingually
d- decrease blood pressure
**
340-protect from light" in usp means :
a- air tight container
b- plastic container
c- Light resistant container
d- Amber glass
e- Amber plastic
N.B: if the ques. asked about "InUSP " the answer is Amber glass
if not the answer is " Light resistant container"
**
1000 mcg
800 mcg
900 mcg
1200-1300
**
342-most potent anti-inflammatory corticosteroid systemically is :
a-cortisone
b-hydrocortisone
c-triamcinolone
d-prednisone
e- dexmethasone
**
343-suspension eye drop differ than ophthalmic solution in:
a-less commonly used
b- decrease contact time of drug with
eye
c- used for insoluble drugs
d- a&c
**
344-cushing - like syndrome is due to
a) adrenal hyperplasia
b) adrenal hyporplasia
c) Hypothyroidism
d) hyperthyroidism
**
345- Morphine causes respiratory depression by
a) depression of respiratory center in brain
b) activation of respiratory center in brain
c) depression of CTZ receptors center in brain
d) activation of CTZ receptors center in brain
**
346-Calcium-channel blockers mode of action
a) increase the inward calcium to cells
b) decrease the inward calcium to cells
**
347-which is (are) electromagnetic waves??
a)X-ray
b) Beta- ray
c) Gama- ray
d)a+c
**
348-Phenylepherine
a- used in nasal decongestant
b-in high doses stimulate b adrenergic receptor
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**
350- enzyme kinetics law:
A - MichaelisMenten law.
C -franks law
B -henry s law.
.D - Henderson hasselbach law.
**
**
354- Dobutamine is used as:
a- Parasympathomimetic
c- Hypotensive agent
b- In cardiac surgery
d- All of the above
**
**
357- all these drugs used in ameobic dysentery exept
a-metronidazole
b-diloxanid
c-gentamycin
d-tetracyclin
**
358-Example of pathological toxicity:
A-carcinogenesis from chemotherapeutics
B-Hepatic necrosis from acetaminophine
C-dry mouth of antidepressant
**
359- Allopurinol
a- uricosuric
b- Anti-inflammatory
N.b:
1- uricosuric drugs are substances that increase the excretion of uric acid
in the urine, thus reducing the concentration of uric acid in blood plasma
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b-nofodozine
c-trimipramin
d-bupropion
note:
Bupropion is a ( Dopamine/Norepinephrine-Reuptake Inhibitor) used in
smoking cessation.
Nortriptyline (TCA) is used as (off-label) use in smoking cessation.
Champix (Varenicline) is partial nicotine agonist used in smoking
cessation aid also.
**
361- Amount of water in adult male 60%
N.B: male 60 % female about 55%
**
362- Neuromuscular blocker has the lowest t half
Succinylcholine
**
363- Clonidine MOA in treatment of Hypertension:
Alpha2 Agoinst decrease sympath outflow
it inhibits the release of norepinephrine (noradrenaline) in a form of
negative feedback
**
b-amphetamine
c-baclofen
d-
**
365- Hormone released from posterior gland
a-FSH
b-TSH
c-ADH
N.B
1-An I.V infusion of oxytocin is used to induce labor
2-Vasopressin is antidiuretic hormone (ADH)
**
366- Food increase effect of
a-aspirin
b-lisinopril
c-doxycyline
d-Prpranolol
Food may decrease the rate but not the extent of oral absorption of aspirin.
**
367- Hb1genotybe hepatic patient (hepatitis C genotype 1) fot ttt take ?
a-interferon and ribavirin
c-only interferon
d-only ribavirin
**
c- Sucralfate
d- H2 receptor antagonist
Note : PG for prophylaxis Antacid>>>Mg/AL hydroxide
neutralize acidity>>antacids
**
372- drug used for prevention of influenza
a-antiviral
b- vaccination
C-antibiotic
**
B-verapamil
c-amlodipine
D-antacid
d-
N.B:
Sucralfate (aluminum sucrose sulfate) , H2 blocker and PPI are effective in ttt
NSAIDs induced ulcer
The most effective is PPI
prostaglandin analogue (misoprostol ) (cytotec), gastric mucous barrier is
prophylaxis , cant treat the ulcer
**
375- Sodium bicarbonate antacid makes an out elimination of )
A-pka=1.2, weak acid
B-pka=5.1, weak acid
C-pka=7.8, weak base
D-pka= 9 , weak bas
**
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376- a pregnant woman at 43 week pregnancy She began labor actions for
12 hrs. The contractions were strong at first but after some while became
very weak
Which of the following could be useful in her case :
A- ergotamine
B- saline infusion
C-oxytocin
**
b-mebendazol
c- Niclosamide
c- alginic acid
**
384-Anemic patient refuses to take injection so DOC:
a- Iron sucrose
b-Ferrous gluconate
c-Vit. b12
Note : ferrous gluconate taken orally
iron sucrose .. injection
**
385-the drug that most likely causes peptic ulcer
a- ibuprofen
b-indomethacin
c-diclofenac
d-naproxen
If there is piroxicam or ketorolac in choices choose them better
**
386- Drug that increases paracetamol toxicity
a-Alcohol ( ethanol )
b-phenobarbitone
**
386- Dopamine is used in cardiac shock as ..
a-don't induce peripheral vaso construction
b-decrease c.o.p
c-dec. force of contraction
d-selective dilate renal and mesenteric(vasodilation) **
387- Dopamine is used in cardiac shock as:a) decrease C.O.P.
**
393-Overdose of the following lead to prolongation of Qr and bradycardia
a-propranol
b-verapamil
c-captopril
**
394-Pregnant woman have hepatitis B when deliver we must give for baby?
A. Hepatitis B vaccine only
B. Hepatitis B vaccine with interferon
C. Hepatitis B vaccine with immunoglobulin hepatitis.
D-Hepatitis B immunoglobulin with lamivudine
**
395- According to FDA the most dangerous abbreviation that shouldnt be
written on prescription is???
a-Ac
b- pc
c- prn
d- pe
**
396- 85 years man have pain in joint .. what the most dangours abbreviation
put in prescription ?
a-Qid
b-P.R.N
c-pe
d-OD
OD meaning Once daily Mistaken as right eye (OD-oculus dexter), leading
to oral liquid medications administered in the eye SO it can be fatal
QD (Every day), QOD (Every other day), Q1d (Daily) If any of them in
choices choose them . Because these abbreviations can be mistaken
with QID (Four times daily).
**
397-drug decreases warfarin action
A-Multivitamins
B-Paracetamol
A-spironolactone
B- Furosemide
C-propranolol
Dinsulin
N.B:
aminoglycoside may exist instead of spironolactone
i.e aminoglycosides and any potassium sparing diuretics(spironolactone
,triamterene and amiloride) is C.I with any kidney diseases
**
399-12 years old boy has diabetes type1 which drug can take?
A.metformin
B. glipizide
C. Pioglitazone
D. glibenclamide
Note :
if " insulin" is an option .. choose it .
**
400- Megaloplastic anemia folic acid /cyanocoblamin..i.e (vitb9+vitb12)
N.B: Pernicious anemia. Deficiency of vit b12 ..Only
**
401-Indapamide used in
a-Essential hypertenstion
failure
b-Angina pectoris
c-Heart
Indapamide used in hypertension or for swelling " salt and water retention
due to congestive heart failure
(Indepamid is thiazide diuretic)
**
402- ethosuximide is antiepileptic used in absence (petit mal) seizure
**
403-A Child with otitis media ,,, high dose amoxicillin
**
404- hormone is released from adrenal cortex Adrenocorticotropic
a-oxytocin
b-progesteron
Hormone released from posterior gland Vasopressin and oxytocin.
**
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Used with caution = generally safe in short term use with least possible
effective dose
**
408-A drug for hyperthyroidism associated with a agranulocytosis is
propyl thiouracil
**
409- Bioavailability refers to the extent and rate at which the active moiety
(drug or metabolite) enters:
a- systemic circulation ( the site of action)
b- intestine
**
410- Hb1Vgenotybe hepatic patient for ttt take ?
a.interferon and ribavirin
b- First ribavirin then interferon
c-only interferon
d-only ribavirin
**
411-A pregnant women with syphilis should take
a- ampicillin
B-amoxicillin
c- clavulanate
b- ciprofloxacin
B. Beta 2 antagonist
D. Leukotriene modulator
B. Beta 2 antagonist
c. cortecosteroid
D. leukotrine modulator
B. Ethyl propyl
C. Autoclave
**
427- A Drug that may cause arrhythmia Digoxin
**
428-drug need to monitor its plasma level Gentamycin
**
429-drug make complex with dairy product Ciprofloxacin
**
430- Drugs that make complex with antacids?
(tetracyclines and fluoroquinolones)
N.B: Aluminum, magnesium in anti-acid s and calcium in dairy products, all
of these cations make a complex with fluoroquinolone and tetracycline
antibiotics
**
431-Drug makes complex with antacid
A-Warfarin
b-propranolol
c-Doxycycline
**
432- Antiarrhythmic drug class 1A Disopyramide
N.B class A 1 : quinidine, Procainamide & dispyramide
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**
433- Which the following hormone suppress due to take oral contraception:
A) FSH( Follicle-stimulating hormone)
B) LH(Luteinizing hormone) (in phase of ovulation)
C) GnRH (Gonadotropin-releasing hormone)
**
434-in ovulation phase, Which hormone predominate?
a-FSH
b-LH
C) GnRH
1.Lh hormone is predominate in ovulation phase.
2.Contraceptives make feedback inhibition to (GNRH )hormone
**
435- A small group of medications in any health organization that medical
staff deal with them in caution and their loss from the place cause a very
serious problem so there is special way to store and dispense them
A- Low alert drugs
B- High alert drugs
C- Narrow therapeutic index
**
436- Sign of shock:
A. Hyper infusion
D. Bradycardia
B. Hypoperfusion
C. Tachycardia
**
437- Antidote of DIGITALIS ? Fab fragment
**
438-Drug interaction of heparin:
A-antacid
B- Aspirin
N.B: Aspirin replace heparin in plasma protein bind Increase the effects of
heparin. And risk of bleeding
**
439- Mechanism of action of Dopamine : Dopamine b1agonist
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**
440-MOA of Chorionic gonadotrophic during of treatment of infertility?
A. Follicle
ovulation
**
441-sevelamer is to treat Hyperphosphatemia(Renagel)
**
442- Antiviral for HIV which nucleoside reverse transcriptase inhibitor
zidovudine
**
443-Route of administration of morphin and enoxaparin ??
Morphine IV ,,,,,,,,, Enoxparin SC
Note: Morphine can be taken also as: Oral, IM, Rectal
**
444-the LABEL of drug should has:
A. Patient name
B. Physician name
C. Physician number
The label must contain the pt. name due to no other pt. take this
drug
Prescription must contain physician name
**
445- All of the following to decrease exposure to radiation except:
a-increase the distance from radiation source
radiation
c-put shelves
person
b- diarrhea
**
b-storage
c-Administration
d-
**
451- A pregnant woman has deep vein thrombosis (DVT) hospitalized
treated by:
unfractionated heparin
**
Doses qusetions
Vitamin D
Calcium
Folic acid
Geriatrics
Adult.....1000mg
Male......400mcg
<70years....600Iu
Pregnant
....1200mg
Female....400800mcg
> 70years...800iu
Geriatric ....1200mg Pregnant.....600mcg
Pregnant....600iu
Adult...600iu
**
452- A Drug causes sodium and water retention
A.indomethacin
B.verapamil
C.atenolol
D.ACEI drugs
Indomethacin if there is no Minoxidil in choices
**
453-Which of the following induce diarrhea Indomethacin
**
454-Phenytoin effect decrease by
a- kidney impairment
b-using isoniazid
**
455- streptokinase is used in
a-T.B
b-myocardial infarction
c-increase fat absorption
**
456-Vitamin k is antidote of
A-warfarin
B-Digoxin
C-heparin
**
457-Antidote of heparin is
a- vitamin k
c-propranolol
b-Protamine sulfate
d-desferoxamine
**
Drug
1-warfarin
2-Heparin
3-urokinase
Streptokinase ,alteplase
Reteplase,
Tenecteplase
4-paracetamol
5-morphine
6-Iron
antidote
I.V vitamin K (phytonadion)
Protamine sulfate
aminocaproic acid
tranexamic acid
N- Acetyl cysteine
Naloxone
Deferoxamine
**
458-Atropine is
a- Muscarinic agonist
b- Muscarinic antagonist
c- Nicotinic agonist
D-nicotinic antagonist
**
459-Benefits of using the unit- dose system:
To decrease medication errors (dose errors)
**
460- MOA of cromolyn ( cromolyn sodium)
a- anti-leukotriene
b- mast cell stabilizers
c- pg modifier
**
461- Treatment of patient with chronic wheezing and cough:
A-corticosteroid
B-beta 2 agonist
**
462-which of the following prevents Neural tube defects ( birth defects)
Folic acid (vit. B9)
**
463- Category X
Category X
Studies in animals or humans have demonstrated fetal abnormalities
and/or there is positive evidence of human fetal risk based on adverse
reaction data from investigational or marketing experience, and the
risks involved in use of the drug in pregnant women clearly outweigh
potential benefits.
Example drugs: atorvastatin, simvastatin, warfarin, methotrexate,
finasteride
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**
464- The task of pharmacists and medicine centers& hospitals
Control formulary of drugs
**
465- Verapamil inhibit metabolism of
a- Digoxin
b- Sulindac ( NSAIDs)
c-Naproxen
d-Piroxicam
**
466- MOA of antiarrhythmic Class 1A (quinidine)
a- Increase rate of phase 0 depolarization,
b- decrease rate of phase 0 depolarization
**
467-Acetaminophen for a patient with osteoarthritis suffering from pain
**
468- Drug that is susceptible to cause drug dependence:
Benzodiazepines
**
469-A drug is contraindicated with patients have G6PD deficiency
suffering from malaria:
A-Chloroquine
B- primaquine
**
470-- Magnesium is contraindicated in renal impairment because of
a-accumulation
b- Decreased absorption
c-increased
reabsorption
**
471- A Child born to a hepatitis B positive mother must take
a-first dose of the hepatitis B vaccine
b-one dose of the Hepatitis B Immune Globulin (HBIG).
c- C. Both of them
**
472- Child on oxcarbazepine for epilepsy and suffers from rash
Change to ethosuximide
**
(Kytril)
B-hyper kalmia
C-hypocalcaemia
D- hypercalcemia
**
B - Asthma
D - Liver failure
c-pneumonias
**
488- Drugs induced cough Except
.Losartan (angiotensin II receptor antagonists)
**
489-MOA of. spironolactone (Adverse effect of Spironolactone (
a-hypokalemia
b-hyperkalemia
c-hypnetermia
**
490.ACEI contraindication ?
a- HTN .
b- angina.
c- arrhythmia.
d- renal failure
**
491. Diltiazem actin? CCB cacuim channel blocker
**
492. LDL indicate ? Arteriosclerosis
**
493- cholestyramin use in ? .ttt hypercholesterolemia
**
494. Used in hyperlipidemic? simvastatin
**
495. Benzodiazepine is used in treatment of ? note:( Anxiolytic and
anticonvulsant)
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a-anxiolytic
(a & c are correct)
b-anti parkinsonism
c-anti-epileptic
**
496.benzyl benzoic acid use ? for ACNE
**
497. Pt. with Low creatinine clearance= high serum creatinine=kidney
injury contraindicated? Gentamycin
**
498- benzodiazepine action? Inhances GABA inhibitory effect
(gamma-Aminobutyric acid( GABA agonist)
**
499Treatment of Diabetic patient with Glycated hb 9 as initial ttt:
a- Metformin
b-glipzide
c-insulin
d-another choice
**
500-Use of combination OCs(Oral contraceptives) contraindicated in
case of
DVT(Deep vien thrombosis)
**
501-A woman had DVT and was treated a year ago ,now she wants to
use oral contraceptive pills
the most suitable ocs for her
a-Levonorgestrel (or l-norgestrel or D-norgestrel)
b-ethinyle estradiol
Note: estrogen increase the risk of DVT
Progestin-only OCs are commonly prescribed when women wish to take
OCs but estrogen
is contraindicated.
Levo=progesterone=synthetic progesterone=second generation
progestin
**
502-pregnant hypertensive woman take
a-prazosine
b-methyldopa
c-propanolo
**
503-Iron deficiency anemia treated with.......iron
b)repolarization due to Na
d) non of them
**
b)repolarization due to Na
d)repolarization due to k
**
b .diabetes
B/800 mg
C/1200mg
**
B/ progesterone
**
B/ tigcyciln
C/ insulin
**
518- note:drugs act as antiestrogen
Clomiphene, tamoxifen,, raloxifen, anastrazol, letrozol
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**
519--A 22 years woman wants to become a pregnant , she is taking
metformin and pioglitazone . she has a history of hypoglycemia and she
prefers oral therapy .. What will be the best approach in her case?:
a - stop pioglitazone and titrate metformin
b - stop both if them and start insulin therapy
c- stop metformin and titrate pioglitazone
d.do nothing
**
520-which drug increase the action of warfarin
A/ carbimazole
B/ oral contractive
C/phenobaritone
**
529 - Pregnant woman with G6PD deficiency has G-ve. M.o. and UTI,
which is the drug of choice to treat her UTI:
A-vancomycine
B-nitrofurantoin
C-cefuroxime
D-sulphamethoxazole
b- Clindamycin
c- cephalexine
d-doxycycline
**
532- Decreased efficacy of epoietin due to deficiency of:
a-b12
b- b9
c - b6
d - b1
**
B- metformine
C-amidrone
D-enalopril
c- increase salivation
**
b- adverse effects
d- drug store
**
protein synthesis
**
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d- antacid
**
b- Lefulonamide
c-
**
549- teatment of digitalis induced arrthymea ......................... phenytoin or
lidocain
**
550- cyanide toxicity ................. cardiac toxicity
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**
551- treatment for severe allergic asthma ? omalizumab used in
Treatment of moderate to severe persistent asthma
Ways to Treat asthma RESPECTIVLY :
1-Short acting beta agonist as salbutamol
2-inhaled corticosteroid
3- long acting beta agonist
4- antiinterleukin
5- oral cs(oral corticosteroid)
6- omalizumab
**
552- daily dose of iron in iron defficency anemia is .......... 100 mg 3 times
daily
**
553- mechanism of action of domperidone & doxazocin
Domperidone has peripheral dopamine receptor blocking properties
(dopamine antagonist) and does not readily cross the blood-brain
barrier.
Doxazosin Competitively inhibits postsynaptic alpha1-adrenergic
receptors.
**
554- BPH is worsen by ...................... anticholinergic drugs
**
555- mechanism of action of benzodiazepine..............GABA agonist
**
556- drugs that physician should care when using it .........
a-low safty drugs
**
Q- Which of the following parameters is the most appropriate for PQ's
self-evaluation of the effectiveness of levothyroxine therapy?
a. Increased energy
b. Weight loss
c. Improved vision
d. Less frequent angina
e. Less frequent urination
**
559- anti acid make complex with:
A-aspirin
B-doxycycline
**
560- most low potency corticosteroid hydrocortisone
**
561-.toxiderm meaning:
A.the toxin that cause syndrome
B.the signs and symptoms of toxcity syndrome
C.the causes of the syndrome made by toxin
D.the syndromes caused by toxin
**
562-anti coagulant taken oral
A . clopidogril
B.streptokinas
C.altepase
D.enoxaprin
**
563-selective beta blocker for treatment glucoma:
A.Betaxolo
B.timolol
C- acebutalol
D-propranolol
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Breast feeding
570-14years-obese girl comes to the clinic with severe rash. She was
initiated on oxcarbazepine about 3 weeks ago for management of partial
seizures.
Her medical history is significant only for seizures. She has recently
become sexually active and admits to inconsistent contraceptive use.
Which one of the following interventions is best for her?
A. Change to carbamazepine.
B. Change to topiramate.
C. Change to valproic acid.
D. No change in therapy is necessary
**
571-A 12 years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethosuxamide
B-shift to topiramate
**
572-PH measures:
A-acidity
B-soluibilty
**
573- If a drug is eliminated by first order elimination, what determines
when will it reach steady state?
c) Drug dose D) t(1/2)
a) Dose interval
b) Elimination rate
half life
Note:f or a drug with one-compartment characteristics, the time to reach
steady state is independent of the dose, the number of doses administered,
and the dosing interval, but it is directly proportional to the half-life.
**
574-A drug induces Water retention
a.indomethacin
b-Verapamil
c-Atenolol
**
575-Bioavailbility Area under the curve
**
576-MOA of Fluoxetine selective serotonin reuptake inhibitor (SSRI)
**
577- Relief pain due to MI (Myocardial Infarction)
A.Morphine
B. Ibuprofen
C- Benzodiazepine
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**
578- Which of the following show penicillinase resistance
a-Penicillin v
b-Flucloxacillin (floxacillin)
c-amoxicillin
d- Augmentin
**
579-the recommended maximum adult daily dose of paracetamol
A-2500 mg
B- 3500 mg
C-4000mg
N.B. Dose for children of paracetamol:
Four years old child should take 240 mg paracetamol per dose,
repeated every four hours, Maximum: 5 doses daily>>>>> so, 5 x 240mg=
1200 mg =1.2g choice: 1g (as age based dose)
The larger the therapeutic index (TI), the safer the drug is. If the TI is
small (the difference between the two concentrations is very small), the
drug must be dosed carefully and the person receiving the drug should
be monitored closely for any signs of drug toxicity.
**
582-A drug with narrow therapeutic index
A -Quinidine
B-Procainamide
C-Phenytoin
**
583- Which of the following drugs are considered drugs dependence in
normal dose???
a- Valproate
b-phenytoin
c-fluxetine
(Prozac)
d-quindine
N.B: Fluoxetine is a selective serotonin reuptake inhibitors (SSRI)
antidepressant
**
584- A drug has Dose-dependent according to pharmacokinetic
parameter
A-phenytoin
B-quinidine
**
585- A patient with iron deficiency anemia refused to take any parenteral
drugs
give him
a-ferrous gluconate
b- Iron sucrose
cOther
choices
**
586-which drug has the rapid effective action in esophageal burn and
acidity
A-omeprazole
B- magnesium/aluminum hydroxide
c - Other choices
**
587- Studies in which data collected from different studies
A-double blind
B-systematic review C-other choices
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Note : meta analysis is better answer if not exist the answer will be
systematic review
**
588- Naloxone exert its action through...antagonism
**
589- African American women take lisinopril and another hypertensive
drug suffer from nose swelling and other symptoms what make her more
suspected to this reaction
a-age
b - Gender
c-drug combination
d- ethnicity
Note :
- Black patients have low renin than normal
-ACEI (lisinopril) causes angioedema more in african americans
if no ethnicity in choices .. choose Drug combination
**
590- MOA of Benzodiazepine?
a- Anxiolytic
c- Ant Parkinsonism
b-Antiepileptic
d-anti-psychotic
**
b.Oubain
c.Digitoxin
d.Amrinone
**
592-A patient who is taking sevelamer drug means that he/she suffers
from
a-hyper phosphatemia
b--hyper calcemia
c-hyper magnesiumea
**
593-Mg antacid for patient with renal failure the antacid will cause
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b-metformin
d-clonidine
**
clotrimazole
**
599-Dopamine causes:
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2-Distribution
3-Metabolism
4-Excretion
**
601-.which antacid give cathartic effect as a side effect
A-Mg hydroxide
B-Ca sulfate
C-Ca hydroxide
**
602-.Cimetidine is
enzyme inhibitor
**
urine retention
**
612- A 12 years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethoxsumide
B-shift to topiramate
**
613- rapid relief of acidity...Al hydroxide
**
614-MOA of Labetalol
Labetalol is a selective alpha-1 and non-selective beta adrenergic blocker
used to treat high blood pressure. It works by blocking these adrenergic
receptors cardiac output.
**
615-MOA of :(Isoprenaline)
Non selective stimulant
1- 1 works on heart as Agonist------strengthens the action of heart
2- 2: Agonist works on lung---------------- Dilate lung for asthmatic
patient
Sympathomimetic
Bronchodilator Agents
Cardio tonic Agents
Adrenergic beta-Agonists
**
616- A drug Treats Bph by relaxation of bladder neck?
A-Terazocin
B-metolol
N.B: Bph (benign prostatic hyperplasia (enlarged prostate)
Terazosin is alpha-adrenergic blockers so it relaxes arteries so that
blood can more easily pass through them. It also relaxes the muscles in
the prostate and bladder neck, making it easier to urinate.
**
617- Decreases effect of phenytoin?
A-Isoniazid
b- Alcohol
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632-A case of 22 years old woman that wants to get pregnant, she takes
Pioglitazone with metformin as her treatment. She has a history of
hypoglycemia and she prefers to take oral therapy. What will be the best
approach in her case?
a-stop both drugs and take insulin
b-stop metformin and titrat the pioglitazon
c-stop pioglitazone and titrate the metformin
d- do nothing
**
633-case in which glucose is high and its weight 103 kg and ha1c is 9, he
will take..
A-metformin
B-insulin
C-glyclizide
Metformin as weight is an indication for type 2diabetes
**
634-case 12_years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethoxsumide
B-shift to topiramate
**
635- a pregnant woman in her third week she take levothyroxine 100 mcg
, you advise her :
a) stop the medication immediately
b) increase the dose of levothyroxine
c) ask the prescriber to change the medication
d) continue using the medication as prescribed
Levothyroxine is considered the treatment of choice for the control of
hypothyroidism during pregnancy.
Due to alterations of endogenous maternal thyroid hormones, the
levothyroxine dose may need to be increased during pregnancy and the
dose usually needs to be decreased after delivery.
**
636) The lowest in potency
a)Dexamethasone
b)Triamcinolon
d)Betamethasone
c)Hydrocortisone
**
637-The ability of liquid to dissolve in another liquid is called
A- Solubility equilibrium
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B- solvation power
C- Miscibility
D- Hydrophilicity
**
638-ACEI role in CHF
A.alpha 1 blocker
B.block ca influx to cells
C.prevent ventricular remodeling
D.cannot remember but wasnot related to angiotensin
**
639-.dispyramide as anti arrhythmia:
A.dec. phase 0
B.inc. phase 0
C.dec. phase 3
D.inc phase 3
**
640-.drug interact with statin:
A . aspirin
B Ketoconazole
C-Carvedilol
**
641-. vitamins prevent fetus abnormalities. .
A.iron
B.ca
C.vit a
D.vit b9
N.B. vitb9 ( folic acid )
**
642-antiestrogen cause abortion..>> anastrozole
- antiesterogen used in breast cancer>> .. tamoxifen
**
643-.Antiprogesterone cause abortion.. Mifepristone
**
644-.Drug known to cause kidney injury
A.Thiazide
B. Aminoglycoside
**
645-.carpidopa act anti-parkinsonism by..
A. block dopamine receptor
B.inc. dopamine
NOTE: Carbidopa mechanism: is a peripheral decarboxylase inhibitor. It
inhibits the peripheral decarboxylation of levodopa to dopamine; and as it does
not cross the blood-brain barrier, unlike levodopa, effective brain
concentrations of dopamine are produced with lower doses of levodopa.
That is why carbidopa is used in combination with levodopa to treat
Parkinsonism.
**
646--MOA of Amlodipine:
Calcium channel blocker (CCBs) Block calcium and block contractility of
heart and induce vasodilatation of blood vessel
Note: Verapamil , diltiazem block Ca on heart
Amlodipine , nifedipine block Ca on Blood vessel and heart
**
647-anti arrhythmic cause lupus :
A-procainamide
B.quinidine
N.B:
1-The most common medicines known to cause drug-induced lupus are:
Isoniazid.
Hydralazine.
Procainamide.
2- lupus is any of various diseases or conditions marked by inflammation
of the skin, especially lupus vulgaris or lupus erythematosus
**
648-pharmacological uses of cholestyramine is anti hyperlipidemic
**
649-pharmacological benefit of cholestyramine
a-increase LDL
b-decrease HDL
c- Increase efficiency of lipoprotein removal
d-decrease LDL
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b. beta
one. For drugs to be effective they need to be able to move rapidly from
blood plasma to other body fluids and tissues.
**
671- method used in sterilization (autoclave was not in the choices:
a-radiation
b- dry heat
c-moist heat
**
d-avoid antibiotic
**
673-ceftazidime is third generation cephalosporin
b-decrease hypertenstion
**
701- LDL is responsible for transportation of:
1-lipids from cell to cytoplasm
2-cholesterol
3-fats to tissue
Low density lipoproteins (LDLs) carry cholesterol from the liver to body
cells.
**
702- PPI (Proton Pump Inhibitor) is used in GIT bleeding is:
1-omeprazole
2-pantoprazole
3-esomprazole
**
703_ Ophthalmic preparation should have these properties except:
A-sterile
B-purified
C-should contain preservative sitotosc
d- isotonic
**
704_ Altepase used is
a.Acute coronary syndrome
b.Neoplastic disorder
c.Fat metabolism
d.Acute bacterial infection
**
705. Which is category X ?
a.Ciprofloxacin
b.Rituximab
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N.B:
FDA pregnancy category : C use rituximab only if clearly needed and
benefit outweighs risk
FDA pregnancy category : C Cirofloxacin should not be used during
pregnancy unless the potential benefits justifies the potential risk to both
fetus and mother
**
706.Quinidine is similar in its action to ?
a.phenytoin
b.lidocaine
c.procainamide
**
**
Important Notes :
- intrinsic sympathomimetic activity DRUGS :
pin= pindolol
ox= oxprenolol
ac=acebutelol
- electromagnetic ray incude ( radio, micro, ultraviolet, x_ray,
gama )
- Terbutaline is used as >> Antiasthmatic
- Freeze drying is done by >> Sublimation.
- Converting big fragments into small fragments is >>
Reduction
- q.d.s = q.i.d = four times per day
- p.r = for the rectum
- qqh means every 4 hours
- Bretylium class3 anti antiarrythmic is an adrenergic neuronal
blocking agent
- ceftazidime is 3rd generation cephalosporin
- Amantadine is dopamine agonist
- Diphtheria is an upper respiratory tract illness (makes tough
pharyngeal membrane) caused by Corynebacterium
diphtheria
- Indamide use ------ sulphonyle urea "Diabetic treatment"
indapamide ( natrilix) ---- thiazide diuretic
- Drug used in abscence seizure (petit mal seizures).....
ethosuximide
- ANGIOTEC is the trade name of Enalapril
- The parameter describing dissociation in solution: pka
- Reserpine mechanism: deplete catecholamines from
sympathetic nerve endings
- MAOI work through: increase avialability of monoamine
neurotransmitter
- All the following side effects of atropine:
urine retention, constipation, blurred vision, dyspnea
- Mechanism of action hydrochlorothiazide: inhibition NA
reabsorption in the distal tubules causing increased excretion
of sodium and water as well as potassium and hydrogen ions.
- Phase 1 of Arrhythmia: Transient early repolarization, due to
potassium efflux
- Phase 2 of Arrhythmia: plateau Phase Calcium influx
continues and is balanced to some degree by potassium
efflux
- Main side effect of nitrites is..headache
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IV = intervenes
Pulv. = powder
Gtt or gtt = drop, drops
elix = elixir
comp. = compound, compounded
g or GM =gram
gr or gr = grain
gal = gallon
Cc or cc. cubic centimeter
oz. = ounce
M2 or m2 = square meter
l or L = microlitre
Mcg, mcg or g = microgram
I or L = liter
Lb = pound
mEq = milliequivalent
mg = milligram
ml or Ml = milliliter
fl or fld = fluid
fl oz = fluid ounce
dl or dL = deciliter
cp = chest pain
D.A.W. described as written
GI = gastrointestinal
Non rep. = do not repeat
H = hypodermic
NPO = nothing by mouth
N.S., NS = normal saline
NS = half-strength normal saline
O = pint
IVP = intervenous push
IVPB = intervenous piggyback
OTC = over the counter
K =POTASSIUM
PDR = Physicians, Desk Reference
= Greek mu
M = mix
Ppt = precipitated
p.o. = by mouth
Pr = for rectum
Pv = vagenal use
Prn or p.r.n. = as needed
Pt. = pint
N & V = nausea & vomiting
N.F. = National formulary
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ante = before
a.c. = before meals
p.c. = after meals
h or hr. = hour
q. = every
q.d. =every day
q.h. = every hour
q.4 hr. = every 4 hours
b.i.d. = twice daily
a.m. = morning
Noct. = night, in the night
h.s. = at bed time
**
Dont Forget to Study the other Files (Cases &Calculations)
GOOD LUCK