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    Complexometric Titration

    Uploaded by

    Antonette Ong
    The document discusses complex formation titration using the chelating agent EDTA. It provides details on: - How EDTA forms 1:1 complexes with most metal ions by binding through four oxygen and two nitrogen atoms. - Titration curves for the reaction of EDTA with metal ions like Fe, Zn, Ca, Hg at pH 10. - Stability constants for various metal-EDTA complexes. - Techniques for complexometric titrations like back titration and displacement titration. - How auxiliary complexing agents prevent metal hydroxide precipitation during titration. - Examples of applications like determining hardness of water and cyanide content.

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    © All Rights Reserved
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    Complexometric Titration

    Uploaded by

    Antonette Ong
    116 views8 pages
    The document discusses complex formation titration using the chelating agent EDTA. It provides details on: - How EDTA forms 1:1 complexes with most metal ions by binding through four oxygen and two nitrogen atoms. - Titration curves for the reaction of EDTA with metal ions like Fe, Zn, Ca, Hg at pH 10. - Stability constants for various metal-EDTA complexes. - Techniques for complexometric titrations like back titration and displacement titration. - How auxiliary complexing agents prevent metal hydroxide precipitation during titration. - Examples of applications like determining hardness of water and cyanide content.

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    complexo notes

    Original Title

    complexometric titration

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    The document discusses complex formation titration using the chelating agent EDTA. It provides details on: - How EDTA forms 1:1 complexes with most metal ions by binding through four oxygen and two nitrogen atoms. - Titration curves for the reaction of EDTA with metal ions like Fe, Zn, Ca, Hg at pH 10. - Stability constants for various metal-EDTA complexes. - Techniques for complexometric titrations like back titration and displacement titration. - How auxiliary complexing agents prevent metal hydroxide precipitation during titration. - Examples of applications like determining hardness of water and cyanide content.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    116 views8 pages

    Complexometric Titration

    Uploaded by

    Antonette Ong
    The document discusses complex formation titration using the chelating agent EDTA. It provides details on: - How EDTA forms 1:1 complexes with most metal ions by binding through four oxygen and two nitrogen atoms. - Titration curves for the reaction of EDTA with metal ions like Fe, Zn, Ca, Hg at pH 10. - Stability constants for various metal-EDTA complexes. - Techniques for complexometric titrations like back titration and displacement titration. - How auxiliary complexing agents prevent metal hydroxide precipitation during titration. - Examples of applications like determining hardness of water and cyanide content.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 8

    Complex Formation Titration

    L. dlC. Coo

    Analytically useful chelating agents

    Chelate covalently attached to an antibody carries a metal


    isotope (M) to deliver lethal doses of radiation to tumor cells.

    Orally taken iron chelator


    Part of treatment of thalassemia

    EDTA forms 1:1 complexes with most metal ions, binding


    through the four oxygen and the two nitrogen atoms.

    Titration Reaction:
    Mn+ + H2Y2-

    MY4-n + 2H+

    Titration curves for the


    reaction of 50.0 mL of
    0.0400 M metal ion
    with 0.0800 M EDTA
    at pH 10.

    KFeYKFeY-2
    KCaY-2
    KHgY-2
    KZnY-2

    =
    =
    =
    =
    =

    KFeY- = 1.3 x 1025


    KZnY-2 = 3.2 x 1016
    KCaY-2 = 5.0 x 1012

    1.3 x 1025
    2.1 x 1014
    5.0 x 1012
    6.3 x 1021
    3.2 x 1016

    KHgY-2 = 6.3 x 1021


    KFeY-2 = 2.1 x 1014

    Techniques
    1. Back titration

    2. Displacement Titration
    -unavailability of a suitable indicator

    An auxiliary
    complexing agent
    like NH3, tartrate,
    citrate or
    triethanolamine,
    prevents precipitation
    of metal hydroxide.

    Metal ion indicators change color when they bind to a metal ion.

    Hardness of water
    A 100-mL sample of water containing Ca2+ and
    Mg2+ ions is titrated with 15.28 mL of 0.01016
    M EDTA in an ammonia buffer at pH 10.00.
    Another sample of 100 mL is treated with
    NaOH to precipitate Mg(OH)2, and then
    titrated at pH 13.00 with 10.43 mL of the same
    EDTA solution. Calculate the ppm of CaCO3
    (100.09) and of MgCO3 (84.314) in the sample.

    Liebig Titration of Cyanide with AgNO3


    Basis: 2 CN + Ag+  Ag(CN)2

    K ~ 1021

    End point: appearance of turbidity due to the


    precipitation of silver cyanide.

    or

    Ag+ + Ag(CN)2  2 AgCN (s)


    Ag+ + Ag(CN)2  Ag[Ag(CN)2] (s)

    Deniges modification: iodide ion is added since AgI is


    less soluble than silver cyanide; NH3 is added
    Ag(NH3)2+ forms which retards the precipitation of
    AgI until very near the equivalence point.

    Example. A 0.7562-g sample containing


    NaCN is dissolved in H2O and then
    concentrated NH3 and some KI solution are
    added. The solution requires 23.58 mL of
    0.0988 M AgNO3 for titration. Calculate the
    percentage of NaCN (49.007) in the sample.

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