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International Journal of Pharmaceutical and Clinical Research 2010,2(2), 90-94

Review Article

ISSN 0975 1556

PLANT REVIEW: Butea monosperma

Sindhia V.R.1, Bairwa R.2
1

Institute of Pharmacy, Bundelkhand University Jhansi (U.P.),India

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India

ABSTRACT
Butea monosperma (Lam.) Kuntze (Syn. Butea frondosa; Family Fabaceae) , This is a moderate sized deciduous tree
which is widely distributed throughout India , Burma and Ceylon, popularly known as 'dhak' or 'palas', commonly
known as Flame of forest. The family Fabaceae compromises of 630 genera and 18,000 species. The crude extracts
of various parts and pure isolates of Butea monosperma was reported to possess antibacterial, antifungal,
hypoglycemic, anti-inflammatory activities. Butea monosperma have been found to possess tonic, astringent,
aphrodisiac and diuretics properties. The widespread uses of Butea monosperma in traditional systems of medicine
have resulted in their extensive chemical analysis for their bio-active principles. This article briefly reviews the botany,
chemistry and pharmacology of Butea monosperma (Lam) Kuntze.
Keywords: Butea monosperma, fabacear, dhak, palas.
INTRODUCTION
It is evident that without nature human being life is
impossible. There are three basic necessity of humans is
food, clothes and shelter and now the fourth one is good
health, which provided by plant kingdom. Nature stands
a golden mark and provided the storehouse of remedies
to cure all ailments of mankind. Plant kingdom
represents a rich house of organic compounds, many of
which have been used for medicinal purposes and could
serve as lead for the development of novel agents having
good efficacy in various pathological disorders in the
coming years. Herbs have always been the principal
form of medicine in India and presently they are
becoming popular throughout the world, as people strive
to stay healthy in the face of chronic stress and pollution,
and to treat illness with medicines that work in count
with the bodys own defence. There is a widespread
belief that green medicines are healthier and more
harmless or safer than synthetic ones.
In traditional medicine , there are many natural crude
drugs that have the potential to treat many disease and
disorders one of them is Butea monosperma (Lam.) Taub
(Syn. Butea frondosa; Family Fabaceae) popularly
known as 'dhak' or 'palas' ,commonly known as Flame
of forest, palash , mutthuga ,bijasneha, khakara,
chichara , Bastard teak , Bengal kino.(1)
They comprise one of the largest families of flowering
plants, numbering 630 genera and 18,000 species.(2)
This is a moderate sized deciduous tree which is widely
distributed throughout India , Burma and Ceylon
extending in the north west himalayas as far as jhelum
except in very acrid parts. (3)
Corresponding Author
Email: [email protected]

It is one of the most beautiful tree has been put to some

useful purpose. Butea monosperma is extensibly used in
Ayurveda, Unani and Homeopathic medicine and has
become a cynosure of modern medicine. The plants of
this genus are well known for their colouring matters.
Commonly Butea monosperma is used as tonic,
astringent, aphrodisiac and diuretics. (4).
Roots are useful in filariasis, night blindness,
helminthiasis, piles, ulcer and tumours. (5) It is reported
to possess antifertility, aphrodisiac and analgesic
activities. (2)
Flowers are useful in diarrhoea, astringent, diuretic,
depurative and tonic (33). The stem bark is useful in
indigenous medicine for the treatment of dyspepsia,
diarrhoea, dysentery, ulcer, sore throat and snake bite.
Besides medicinal uses it is also having the economic
use such as leaves are used for making platters, cups,
bowls and beedi wrappers (2)Bark fibres are used for
making cordage.(1) Wood is used for well curbs and
water scoop. It is a cheap board wood .Wood pulp is
suitable for newsprint manufacturing. (6) Butea is also a
host to the Lac insect, which produces natural lacquer.
(61)
Butea superba is a native herb in the family of
Popilionaceae. The Plant twinning woody long-life
herbal plant exists only in Thailand. This species can be
found in the same habitat as Pueraria Mirifica in the
mountainous area. The long shape tuberous were
annually enlarged and accumulated at least 15 chemicals
in the group of direct chain organic acid especially
flavonoids and flavonoid glycosides with c-AMP
Phosphodiesterase potent inhibitor directly at the corpus
cavernosum of the penis and resulted in enhancing blood
flow to that area. In addition, it supports normal sexual
function, erectile capacity, enhance sensitivity and better

Sindhiya V.R., Bairwa R / Plant review: Butea monosperma

performance. The preparation of Butea superba tubers
has been used as an alternative herbal treatment for
erectile dysfunction in males. (7) The tubers of Butea
superba have been found to contain estrogenic
substances similar to follicle hormones. (8) Roots of
Butea superba show rejuvenating activity (9). The root
barks of Butea superba shows 65% inhibitory activity on
acetylcholinesterase.(10)
Butea parviflora also known as climbing Butea and
palashabheda, is a large woody licine with large trifoliate
leaves, white or cream coloured flowers and single
seeded fruit found throughout in india. Roots contain
rotenone.

hairs, orange or salmon coloured: standard 2.5 cm broad:

keel semicircular, beaked, veined. Pods stalked 12.5-20
by 2.5-5 cm, thickened at the sutures, reticulately veined
argenteocanescent: stalked 2 cm long (1, 2).

CHEMICAL CONSTITUENTS
Flower - Triterpene (35),several flavonoids butein, butin,
isobutrin, coreopsin, isocoreopsin (butin 7-glucoside),
sulphurein, monospermoside(butein 3-e-D-glucoside)
and isomonospermoside, chalcones,aurones, isobutyine, ,
palasitrin, 3',4',7- trihydroxyflavone (11).
Myricyl
alcohol, stearic, palmitic, arachidic and lignoceric acids
(13 ) glucose, fructose, histidine, aspartic acid, alanine
and phenylalanine (14 )
RO
OH
Gum -Tannins, mucilaginous material, pyrocatechin (1).
OH
Seed - Oil (yellow, tasteless), proteolytic and lypolytic
enzymes, plant proteinase and polypeptidase. (Similar to
yeast tripsin) (2). A nitrogenous acidic compound, along
OR'
with palasonin is present in seeds . It also contains
O
monospermoside
(butein3-e-D-glucoside)
and
somonospermoside(11 ). Allophanic acid, several
flavonoids (5, 6, 7, 4-tetrahydroxy-8-methoxyisoflavone
R = H, R = Glucosyl - Monospermoside , R=R=H 6-O-rhamnopyranoside. (15) Butin (37)-Amyrin, Butein, R=R = Glucosyl - Isobutrin
sitosterol, -sitosterol--D-glucoside, sucrose (16 ),
RO
O
Fatty acids such as myristic, palmitic, stearic, arachidic,
OH
behenic, lignoceric, oleic, linoleic and linolenic (16)
Monospermin(18). And an acid imide.(19) 15Hydroxypentacosanoic acid nheneicosanoic acid lactone (21). 10, 16-dihydroxyhexadecanoic acid
OR'
(22)Phosphatidylcholine, phosphatidylethanolamine and
O
phosphatidylinositol (23 )
Root- The root of Butea monosperma contains glucose,
R =R = H - Butein, R = R= Glucosyl - Butrin,
glycine, a glycoside (aglycon) and an aromatic hydroxy
R=H,R=Glucosyl - Isomonospermoside.
compound (28)
Stem- 3-Z-hydroxyeuph-25-ene and 2,14-dihydroxyRO
O
11,12-dimethyl-8-oxo-octadec-11-enylcyclohexane (58)
CH
OH
Stigmasterol-e-D-glucopyranoside and nonacosanoic
acid (35) Flavonoid 8-C-prenylquercetin 7,4'-di- Omethyl-3-O--L-rhamnopyranosyl(1-4)--LOR'
rhamnopyranoside.(25)
3-hydroxy-9~
methoxypterocarpan [(-)-medicarpin]. Lupenone, lupeol
O
and sitosterol. Two iso flavones 5-methoxygenistein and
prunetin (26). In addition to stigmasterol-3--LR= R = Glucosyl
arabinopyranoside, four compounds isolated from the
BOTANICAL DESCRIPTION
stem of Butea monosperma have been characterized as
An erect tree 12-15 m high with crooked trunk and
3-methoxy-8,9-methylenedioxypterocarp-6-ene,
21irregular branches, bark rough, ash coloured, young parts
methylene-22-hydroxy-24-oxooctacosanoic acid Me
downy. Leaves 3-foliate, petioles 10-15 cm long,
ester, 4-pentacosanylphenol and pentacosanyl--Dstipules linear lanceolate. Leaflets coriaceous (the
glucopyranoside (27).
terminal 10-20 cm long, broadly ovate from a cuneate
Bark - Kino-tannic acid, Gallic acid, pyrocatechin (4).
base, the lateral smaller, 10-15 by 7.5 10 cm, obliquely
Also contains palasitrin, and major glycosides as butrin,
rounded at the base, equilateral, the lower side the
alanind, allophanic acid, butolic acid, cyanidin, histidine,
larger), all obtuse, glabrous above when old, finely silky
lupenone, lupeol, (-)-medicarpin, miroestrol, palasimide
and conspicuously reticulately veined beneath; petioles 6
and shellolic acid (4, 53, 34, 16, 17, 18, 19, 20). Two
mm long, stout-stipels subulate, deciduous. Flowers
compounds, 3, 9-dimethoxypterocarpan, and triterpenoid
large, in a rigid racemes 15 cm long, 3 flowers together
ester, 3- hydroxyeuph-25-enyl heptacosanoate .(27)
form the tumid nodes of the dark olive-green velvety
Leaves - Glucoside, Kino-oil containing oleic and
rhachis: pedicels about twice as long as the calyx,
linoleic acid, palmitic and lignoceric acid. (13)
densely brown-velvety: bracts and bracteoles small,
Resin - Jalaric esters I, II and laccijalaric esters III, IV.;
deciduous. Calyx 13 mm long, dark olive-green, densely
Z-amyrin, e-sitosterone and its glucoside ,sucrose,
velvety outside, clothed with silky hairs within: teeth
lactone-nheneicosanoic acid-{-lactone (51,52)
short, the 2 upper connate, the 3 lower equal, deltoid.
Sap - Chalcones, butein , butin, colourless isomeric
Corolla 3.8-5cm long, clothed outside with silky, silvery
flavanone and its glucosides, butrin (1).
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Sindhiya V.R., Bairwa R / Plant review: Butea monosperma

Biological and Pharmacological Activites
Antifungal activity, antimicrobial activity, antibacterial
activity
The stem bark of Butea monosperma displays antifungal
activity, which is due to the presence of an active
constituent (-)-medicarpin. (26) The seed oil of Butea
monosperma shows significant bactericidal and
fungicidal effect in in-vitro testing (18)
Anti-inflammatory activity
The leaves of Butea monosperma exhibit ocular antiinflammatory activity in rabbits(5 ), The antiinflammatory activity of methanolic extract of Butea
monosperma evaluated by carrageenin induced paw
edema and cotten pellet granuloma. In carrageenin
induced paw edema at 600 and 800 mg/kg inhibition of
paw edema, by 26 and 35% and in cotten pellet
granuloma inhibition of granuloma tissue formation, by
22 and 28%. (36)
Liver disorders
An extract from the flowers of Butea monosperma is
used in India for the treatment of liver disorders and two
antihepatotoxic flavonoids, isobutrin and butrin have
been isolated from the extract (29). The effect of
pretreatment of methanolic Butea monosperma extract
prior to TAA treatment at two doses and the results
suggest that it may contribute to the chemo preventive
effect. Butea monosperma showed a significant recovery
in the level of glutathione and its metabolizing enzyme
in the liver induced the detoxifying enzyme system,
which is shown by the elevated levels of other QR, SOD,
GPx, and xanthine oxidase, which are important phase II
enzymes. (45)
Anticonvulsive activity
It shows anticonvulsive activity, due to the presence of a
triterpene (42). The ethanolic extracts of leaves of
Albizzia lebbeck and flowers of Hibiscus rosa sinesis
and the petroleum ether extract of flowers of Butea
monosperma exhibited anticonvulsant activity. The
acetone soluble part of petroleum ether extract of Butea
monosperma flowers showed anticonvulsant activity.
The fractions protected animals from maximum electro
shock, electrical kindling pentylenetetrazole and
lithiumpilocarpine induced convulsion but failed to
protect animals from strychnine-induced convulsions.
The fractions raised brain contents of gammaaminobutyric acid (GABA) and serotonin. (62)
Antiesterogenic and antifertility activity
Alcoholic extract of flowers of Butea monosperma has
also been reported to exhibit antiestrogenic. (44). Hot
alcoholic extract of Butea monosperma seeds have been
reported for significant anti ovulatory and antiimplantation activities when given to rats and rabbits.
The active constituent has been identified as butin (37).
Butin also exhibits male contraceptive properties (32).
Antifertility effect of seed extract of Butea frondosa has
also been reported in mice. (17) The stem bark of Butea
monosperma, led to the isolation and identification of
three new compounds named buteaspermin A,
buteaspermin B and buteaspermanol, along with 19
known compounds. (43)
Hemagglutinating activity

Seeds of Butea monosperma showing specificity towards

human erythrocytes.(33). The lectins such as Butea
monosperma agglutinin (BMA) isolated from the seeds
of Butea monosperma are responsible for agglutinating
property (64) this property was only shown by seeds not
by flowers, leaves, roots and stems. Human blood groupA-specific agglutinins have been demonstrated in some
of the N-acetyl galactosamine/galactose binding lectins,
such as the lectins. Hemagglutination test showed that
N-acetyl galactosamine is the strongest inhibitor of
agglutination, (40)
Antidiabetic activity
The single dose treatment of ethanolic extract of Butea
monosperma flowers at the dose of 200mg/kg P.O.
significantly improved glucose tolerance and cause
reduction in blood glucose level in alloxan induced
diabetic Rats. (39) .Oral administration of the ethanolic
extract of the Butea monosperma seeds at the dose of
300mg/kg b.w., exhibited significant antidiabetic,
hypolipaemic and antiperoxidative effects in non-insulin
dependent diabetes mellitus rats. (41)
Wound healing activity
The topical administration of an alcoholic bark extract of
Butea monosperma on cutaneous wound healing in rats.
Full-thickness excision wounds were made on the back
of rat .The granulation tissue formed on days 4, 8, 12
and 16 (post-wound) was used to estimate total collagen,
hexosamine, protein, DNA and uronic acid. The extract
increased cellular proliferation and collagen synthesis at
the wound site, as evidenced by increase in DNA, total
protein and total collagen content of granulation tissues.
The extract treated wounds heal much faster than normal
animals as indicated by improved rates of
epithelialisation and wound contraction, tensile strength
and histopathological examinations. Butea monosperma
exhibited wound healing activities due to its antioxidant
properties. (60)
Diarrhoea
Butea monosperma gum has also been found useful in
cases of chronic diarrhoea. It is a powerful astringent
and also decreases bilirubin level (65)The ethanolic
extract of stem bark of Butea monosperma at 400 mg/kg
and 800mg/kg inhibited castor oil induced diarrhoea due
to inhibiting gastrointestinal motility and PGE2 induced
enteropooling. It is used as nonspecific anti diarrhoel
agent in folk medicine. (39).
Giardiasis
Giardiasis is a common gastrointestinal infection caused
by a protozoa1 parasite, Giurdia lamblia. Pippali
rasayana (PR), an Ayurvedic herbal medicine, prepared
from Piper longum (Pippali) and Butea monosperma
(Palash) in which ash of stem, root, flower and leaves of
Butea monosperma is used, has significant activity
against Giardiasis It produced up to 98% recovery from
the infection. The rasayana had no killing effect on the
parasite in vitro. It induced significant activation of
macrophages as evidenced by increased macrophage
migration index (MMI) and phagocytic activity. With
higher doses of PR recovery increased up to 98% at 900
mg/kg (63) Flowers of this plant are also effective in
leprosy, leucorrhoea and gout (2)
Anthelmintic activity

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Sindhiya V.R., Bairwa R / Plant review: Butea monosperma

The seeds of the plant are used in Ayurvedic system as
an anthelmintic drug. (31) The crude powder of Butea
monosperma seeds (CP) showed a dose-dependent (13
g/kg) and a time-dependent anthelmintic activity in
sheep. The anthelmintic activity of different species of
Butea has been reported against Ascaridia galli, Ascaris
lumbricoides, earthworms, Toxocara canis , Oxyurids,
Dipylidium caninum and Taenia .( 48)
Free radical scavenging
Free radical scavenging activity of various extracts of
flowers evaluated by using different in-vitro models like
reducing power assay, scavenging of 2,2 diphenyl-1picrylhydrazyl (DPPH) radial, nitric oxide radical,
superoxide anion radical, hydroxyl radical and inhibition
of erythrocytes hemolysis using 2,2 azo-bis
(amidinopropane) dihydrochloride (AAPH). Methanolic
extract along with its ethyl acetate and butanol fractions
showed potent free radical scavenging activity. The
observed activity could be due to higher phenolic
contents in the extracts (8).
Thyroid inhibitory, antiperoxidative and hypoglycemic
effects
Stigmasterol, isolated from the bark of Butea
monosperma was evaluated for thyroid hormone and
glucose regulatory efficacy in mice. the administration at
2.6 mg/kg/d for 20 days reduced serum triiodothyronine
(T3), thyroxin (T4) and glucose concentrations as well as
the activity of hepatic glucose-6-phophatase (G-6-Pase)
with a increase in insulin. Showed its thyroid inhibiting
and hypoglycemic properties. Antioxidative potential
due to decrease in the hepatic lipid peroxidation (LPO)
and an increase in the activities of catalase (CAT),
superoxide dismutase (SOD) and glutathione (GSH).
The highest concentration tested (5.2 mg/kg) evoked
pro-oxidative activity. (59)
NUTRITIVE EVALUATION
The nutritive value of leaf extract of Butea monosperma
is OM- 889.2,CP- 150.2,NDF- 506.1, ADF- 356.0,
Cellulose- 151.2, Hemicellulose- 150.2, Lignin- 130.7,
Total phenolics- 6.5, and Condensed Tannins-20.8.(34)
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