Noi Cercetări Emoție - Cogniție

REVIEW ARTICLE
published: 17 February 2015

doi: 10.3389/fnhum.2015.00058
The neurobiology of emotioncognition interactions:

fundamental questions and strategies for future research
Hadas Okon-Singer 1 * , Talma Hendler 2 , Luiz Pessoa 3 and Alexander J. Shackman 3 *
1
Department of Psychology, University of Haifa, Haifa, Israel

Functional Brain Center, Wohl Institute of Advanced Imaging, and School of Psychological Sciences, Faculty of Medicine and Sagol School of Neuroscience,
Tel Aviv University, Tel Aviv, Israel
3
Department of Psychology, Neuroscience and Cognitive Science Program, and Maryland Neuroimaging Center, University of Maryland, College Park, College
Park, MD, USA
2
Edited by:
Leonhard Schilbach, University
Hospital Cologne, Germany
Reviewed by:
Christian Sorg, Klinikum rechts der
Isar Technische Universitt Mnchen,
Germany
Elliot Berkman, University of Oregon,
USA
*Correspondence:
Hadas Okon-Singer, Department of
Psychology, University of Haifa,
Mount Carmel, Haifa 3498838, Israel
e-mail: [email protected];
Alexander J. Shackman, Department
of Psychology, Neuroscience and
Cognitive Science Program, and
Maryland Neuroimaging Center,
University of Maryland, 3123G
Biology-Psychology Building, College
Park, MD 20742, USA
e-mail: [email protected]
These
authors have contributed

equally to this work.
Recent years have witnessed the emergence of powerful new tools for assaying the
brain and a remarkable acceleration of research focused on the interplay of emotion and
cognition. This work has begun to yield new insights into fundamental questions about the
nature of the mind and important clues about the origins of mental illness. In particular,
this research demonstrates that stress, anxiety, and other kinds of emotion can profoundly
inuence key elements of cognition, including selective attention, working memory, and
cognitive control. Often, this inuence persists beyond the duration of transient emotional
challenges, partially reecting the slower molecular dynamics of catecholamine and hormonal neurochemistry. In turn, circuits involved in attention, executive control, and working
memory contribute to the regulation of emotion. The distinction between the emotional
and the cognitive brain is fuzzy and context-dependent. Indeed, there is compelling
evidence that brain territories and psychological processes commonly associated with
cognition, such as the dorsolateral prefrontal cortex and working memory, play a central
role in emotion. Furthermore, putatively emotional and cognitive regions inuence one
another via a complex web of connections in ways that jointly contribute to adaptive
and maladaptive behavior. This work demonstrates that emotion and cognition are deeply
interwoven in the fabric of the brain, suggesting that widely held beliefs about the key
constituents of the emotional brain and the cognitive brain are fundamentally awed. We
conclude by outlining several strategies for enhancing future research. Developing a deeper
understanding of the emotional-cognitive brain is important, not just for understanding the
mind but also for elucidating the root causes of its disorders.
Keywords: ACC, amygdala, anxiety, depression, emotion control and regulation, EEG/ERP, fMRI, PFC
Until the 20th century, the study of emotion and cognition was
largely a philosophical matter. Although modern perspectives on
the mind and its disorders remain heavily inuenced by the introspective measures that dened this earlier era of scholarship, the
last several decades have witnessed the emergence of powerful
new tools for assaying the brain and a remarkable acceleration
of research to elucidate the interplay of emotion and cognition
(Pessoa, 2013; Braver et al., 2014; Dolcos and Denkova, 2014).
The immediate goal of our Special Research Topic was to survey
recent advances in understanding how emotional and cognitive
processes interact, how they are integrated in the brain, and the
implications for understanding the mind and its disorders (OkonSinger et al., 2014b; Figure 1). Here, we consider ways in which
this rapidly growing body of work begins to address some more
fundamental questions about the nature of cognitionemotion
interactions, highlighting key points of consensus. By focusing
attention on the most important outstanding questions, we hope
to move the eld forward. First, we hope that answers provided
by our contributors will stimulate discussion. Second, we hope
that juxtaposing clear theoretical goals against the current state
Frontiers in Human Neuroscience
of the science will motivate new and impactful research. Clearly,

our understanding of emotioncognition interactions remains far
from complete. Indeed, we are reminded of Ekman and Davidsons
comment: There are many promising ndings, many more leads,
[and] a variety of theoretical stances (Ekman and Davidson, 1994,
p. 3). We conclude by outlining several strategies for enhancing
future research. With continuing effort, some of the fundamental
questions will be decisively addressed. In some cases, the questions themselves will evolve, as in other areas of the biological
sciences.
HOW DOES EMOTION INFLUENCE COGNITION?

Many of our contributors highlighted evidence that the perception
of emotionally-salient stimuli and the experience of emotional
states can profoundly alter cognition.
EMOTIONAL CUES GRAB EXOGENOUS ATTENTION AND MODULATE
ENDOGENOUS ATTENTION
There is abundant evidence that emotionally-salient cues

snakes, spiders, and angry facesstrongly inuence attention
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Okon-Singer et al.
Emotioncognition interactions
FIGURE 1 | The top 200 scientific terms used in the Special Research Topic. The typeface is scaled proportional to the frequency of each term. The gure
was generated using http://www.wordle.net.
(e.g., Siman-Tov et al., 2009; Lerner et al., 2012; Pourtois et al., 2013; Carreti, 2014) the ability to selectively
respond to relevant aspects of the environment while inhibiting potential sources of distraction and competing courses
of action (Desimone and Duncan, 1995; Miller and Cohen,
2001). The focus of attention is determined by the pervasive competition between exogenous (often termed stimulusdriven or bottomup) and endogenous (often termed goaldirected or topdown attention) mechanisms (Egeth and Yantis,
1997).
With respect to exogenous attention, a number of contributors describe new evidence that emotionally-charged cues are
more attention-grabbing than neutral cues and highlight recent
efforts to specify the mechanisms underlying this bias (Holtmann
et al., 2013; McHugo et al., 2013; Peers et al., 2013; Stollstorff
et al., 2013). Along the way, McHugo et al. (2013) provide a
useful tutorial on methods for quantifying the capture of attention by emotional cues (e.g., dot-probe, emotional attentional
blink).
Importantly, attention can also be guided in an endogenous
fashion by internal goals (e.g., rules, instructions, and plans)
as well as moods and motivational states (e.g., feeling anxious or hungry). Mohanty and Sussman (2013) discuss evidence
demonstrating that emotion and motivation can guide attention to congruent cues (e.g., food when hungry). In particular,
they show that subcortical regions proximally involved in determining value and orchestrating emotional states (e.g., amygdala,
substantia nigra) can facilitate endogenous attentional processes
implemented in frontoparietal regions and can strengthen activation in relevant sensory regions (e.g., face-selective regions of the
fusiform gyrus when anticipating an angry face). This extended
network, encompassing sensory, attentional, and emotional circuits, facilitates the rapid detection of emotionally-signicant
information.
ATTENTIONAL BIASES TO EMOTIONAL CUES ARE PLASTIC
Anxious individuals tend to allocate excess attention to threat and

there is evidence that this cognitive bias causally contributes to the
development and maintenance of anxiety disorders (Bar-Haim
et al., 2007; Hakamata et al., 2010; MacLeod and Mathews, 2012;
Singer et al., 2012; Van Bockstaele et al., 2013; MacLeod and Clarke,
2015). Extreme anxiety and behavioral inhibition often emerges
early in development (Fox et al., 2005a; Blackford and Pine, 2012;
Fox and Kalin, 2014), raising important questions about the degree
to which childhood attentional biases to threat are plastic and
can be inuenced by early experience (Shechner et al., 2012; BarHaim and Pine, 2013; Henderson et al., 2014; MacLeod and Clarke,
2015).
Here, Kessel et al. (2013) provide tantalizing correlative evidence that emotional biases in attention are inuenced by
caregiver style. Using an innovative combination of behavioral
and electrophysiological techniques, they show that although
temperamentally inhibited children allocate more attention to
aversive cues, this is reduced among the offspring of parents who rely on encouragement, affection, and appreciation to reinforce positive behavior. A key challenge for
future research will be to test whether targeted interventions aimed at cultivating more salubrious parenting styles
have similar consequences. Prospective designs (e.g., before
and after exposure to a negative life event or trauma)
would provide another powerful approach for understanding the plasticity of emotional attention (Admon et al., 2009,
2012).
EMOTION EXERTS PERSISTENT EFFECTS ON ATTENTION
Emotions are often conceptualized as eeting and most imaging

and psychophysiological studies of emotion focus on transient
responses to punctate emotional challenges. Yet, there is growing evidence that emotions can have lingering consequences for
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Okon-Singer et al.
cognition and behavior (Davidson, 2004; Suls and Martin, 2005;

Hajcak and Olvet, 2008; Qin et al., 2009).
Here, for example, Vaisvaser et al. (2013) combined serial
measures of emotional state, neuroendocrine activity, and restingstate brain activity to demonstrate that alterations in amygdala
hippocampal functional connectivity persist for more than 2 h
following exposure to intense social stress. Along conceptually
similar lines, Morriss et al. (2013) use electrophysiological techniques to show that endogenous attention is potentiated for several
seconds following brief emotional challenges (i.e., standardized
emotional images).
Several threads of evidence highlight the importance of understanding the mechanisms that govern variation in the speed
of recovery from emotional perturbation. In particular, individual differences in emotional recovery (a) strongly predict
personality traits, such as neuroticism, that confer increased
risk of developing psychopathology (e.g., Blackford et al., 2009;
Schuyler et al., 2014); and (b) are sensitive to adversity and
chronic stress exposure, two other well-established risk factors (Lapate et al., 2014). An important challenge for future
research will be to identify the neural circuitry and molecular pathways that support the enduring effects of emotion on
endogenous attention and to clarify the intermediate processes
that link variation in emotional recovery to mental health and
disease.
DISTRACTING EMOTIONAL CUES READILY PENETRATE THE GATE
PROTECTING WORKING MEMORY
Endogenous attention is tightly linked with working memory

(Postle, 2006; DEsposito and Postle, 2014; Sreenivasan et al.,
2014). The transient representation of task-sets, goals, and other
kinds of information in working memory plays a crucial role
in sustaining goal-directed attention and guiding behavior in
the face of potential distraction (Miller and Cohen, 2001). In
short, information held in working memory is a key determinant of our momentary thoughts, feelings, and behavior.
Importantly, the capacity of working memory is strongly determined by the ability to lter or gate irrelevant information
(Vogel et al., 2005; McNab and Klingberg, 2007; Awh and Vogel,
2008).
Here, Stout et al. (2013) used a well-established electrophysiological marker of working memory storage (i.e., contralateral
delay activity; Vogel and Machizawa, 2004) to show that threatrelated distractors (i.e., task-irrelevant fearful faces) are stored
in working memory and that this ltering inefciency is exaggerated in dispositionally-anxious individuals. Once in working
memory, emotional information is poised to hijack endogenous
attention and other kinds of topdown control mechanisms. From
a psychiatric perspective, this emotional gating decit may help
to explain the persistence of heightened negative affect (e.g., anxiety, sadness) among patients with emotional disorders (Grupe and
Nitschke, 2013; Cohen et al., 2014; Stout et al., 2014). An important
challenge for future studies will be to use hemodynamic imaging
techniques, such as fMRI, to clarify the neural circuitry underlying
emotional gating decits. A variety of evidence suggests that the
pulvinar may play an important role (Pessoa and Adolphs, 2010;
Arend et al., 2014).
DISTRACTING EMOTIONAL CUES DISRUPT COGNITIVE CONTROL AND

WORKING MEMORY
Classically, cognition and emotion have been viewed as oppositional forces (Damasio, 2005a; Okon-Singer et al., 2007, 2011;
Shackman et al., in press). From this perspective, moods and
other kinds of emotional states are responsible for short-circuiting
cognition.
Consistent with this view, Kalanthroff et al. (2013) show that
emotional distractors disrupt cognitive control. Cognitive control
encompasses the range of processes (e.g., endogenous attention,
inhibition, and learning) that are engaged when habitual responses
are not sufcient to sustain goal-directed behavior, as in stopsignal, go/no-go, Stroop, and Eriksen anker tasks (Shackman
et al., 2011b). Here, the authors demonstrate that the brief presentation of emotional images disrupts performance in the stop-signal
task, a widely used index of inhibitory control (see also Pessoa et al.,
2012).
Likewise, Iordan et al. (2013) review evidence that emotional
distractors disrupt working memory. Converging with other work
focused on emotion-related distraction (Bishop, 2007; Etkin,
2012; Bishop and Forster, 2013; Etkin et al., 2013; Okon-Singer
et al., 2014a; van Ast et al., 2014), they suggest that degraded
performance reects two processes: (a) increased engagement
of regions involved in processing socio-emotional information
and orchestrating emotional expressions (e.g., amygdala), and
(b) a reduction of delay-spanning activity in frontoparietal
cortex.
EMOTION STRENGTHENS SOME COGNITIVE PROCESSES WHILE
WEAKENING OTHERS
With the ascent of evolutionary theory in the 19th century (Darwin, 1872/2009, 1872), many scientists adopted the view that
emotions are functional and enhance tness (Susskind et al., 2008;
Todd et al., 2012; Sandi, 2013; Schwabe and Wolf, 2013; Todd
and Anderson, 2013); in short, that emotions are more adaptive
than not and that there is typically more cooperation than strife
between emotion and cognition (Levenson, 1994).
Consistent with this more nuanced perspective, the contributions from Clarke and Johnstone (2013), Morriss et al. (2013),
Robinson et al. (2013a, 2013b), Vytal et al. (2013) provide evidence that experimentally-elicited anxiety facilitates some kinds
of information processing, while degrading others. In particular,
they provide considerable evidence that anxiety: (a) enhances vigilance, potentiating early sensory cortical responses to innocuous
environmental stimuli, increasing the likelihood that emotionally
salient information will be detected; and (b) disrupts working
memory.
The molecular basis of emotions deleterious impact on working memory is reviewed by Shansky and Lipps (2013). Building
on pioneering work by Arnsten and Goldman-Rakic (1998) and
Arnsten (2009), the authors describe evidence that stress strongly
inuences catecholamine (i.e., dopamine and norepinephrine)
and glucocorticoid levels in the prefrontal cortex (PFC) in ways
that degrade delay-spanning neuronal activity.
Shansky and Lipps (2013) also describe important new evidence that sex hormones, such as estrogen, can exacerbate the
impact of stress on prefrontal function. Along these lines, Sacher
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et al. (2013) review human imaging studies showing that the

structure and function of brain circuits involved in emotion generation and regulation are strongly and dynamically modulated
by cyclic uctuations in sex hormones (see also Sacher et al.,
2012). Taken together, these observations underscore the plasticity of emotioncognition interactions and provide promising clues
about the origins of well-established sex differences in the prevalence of stress-related disorders, such as anxiety and depression
(Kessler et al., 2012; Kendler and Gardner, 2014).
EMOTIONAL STATES PROMOTE MOOD-CONGRUENT THOUGHTS AND
ACTIONS
Moods and other, more transient emotional states tend to

encourage congruent thoughts and actions (e.g., Lerner et al.,
2015), a process that is necessarily mediated by enduring
changes in brain activity and connectivity (cf. Vaisvaser et al.,
2013). Here, Van Dessel and Vogt (2012) demonstrate that
mood increases the amount of attention allocated to moodcongruent cues. Schick et al. (2013) provide evidence that individuals at risk for developing depression interpret motivationally
ambiguous cues in a less positive light. Harl et al. (2013)
describe a novel Bayesian computational framework for understanding the mechanisms underlying mood-congruency effects.
An important advantage of this framework is that it generates explicit mechanistic hypotheses. For example, the model
predicts that anxiety facilitates behavioral avoidance because
it leads to inated expectations about the need for avoidant
behavior and increased expectations of punishment or error.
Furthermore, tting model parameters to observable behavior
affords an opportunity to identify the underlying determinants
of mood-congruency effects in healthy and clinical populations.
EMOTIONAL TRAITS INFLUENCE COGNITIVE PERFORMANCE, EVEN
WHEN EMOTIONAL CUES, AND CHALLENGES ARE ABSENT
Emotional traits are often conceptualized as diatheses for emotional states (Matthews et al., 2009). Thus, individuals with high
levels of neuroticism or negative emotionality are thought to be
prone to exaggerated anxiety in the face of trait-relevant cues,
contexts, and challenges (e.g., punishment, negative feedback), as
illustrated in the contributions from Kessel et al. (2013), Moser
et al. (2013), and Proudt et al. (2013). Yet, a considerable body
of neurophysiological evidence indicates that emotional traits
are embodied in the on-going activity and connectivity of the
brain (Canli et al., 2005; Fox et al., 2008; Shackman et al., 2009;
Rohr et al., 2013; Birn et al., 2014a,b). Likewise, the sustained
levels of heightened vigilance and distress characteristic of individuals with anxiety disorders are most apparent in the absence
of clear and imminent threat (Davis et al., 2010; Lissek, 2012;
Grupe and Nitschke, 2013). These observations raise the possibility that emotional traits could inuence cognition in the absence
of explicit emotional distraction or challenge (Watson and Clark,
1984; Bolger and Schilling, 1991; Suls and Martin, 2005).
Here, Berggren et al. (2013) provide compelling evidence that
trait anxiety is associated with degraded cognitive control, indexed
using an anti-saccade task under load. This new observation
adds to a growing literature showing that hot emotional traits
can inuence cold cognition (Shackman et al., 2006; Eysenck

et al., 2007; Bishop, 2009; Berggren and Derakshan, 2013, 2014;
Cavanagh and Shackman, 2014), a point that we develop more fully
in the subsequent section focused on the integration of emotion
and cognition.
HOW DOES EMOTION INFLUENCE EMOTION?

An important but rarely addressed question in psychology and
psychiatry concerns the potential inuence of emotions on one
another and concomitant motivational states. For example, are we
less likely to experience excitement or joy on a day where were
feeling frazzled, depressed, or worn out (Arnsten, 1998, 2009;
Pizzagalli, 2014)?
EMOTION ALTERS REINFORCER SENSITIVITY
Building on earlier work by Bogdan and Pizzagalli (2006),

Pizzagalli et al. (2007), Bogdan et al. (2010), and Berghorst et al.
(2013) demonstrate that experimentally-elicited anxiety selectively reduces sensitivity to reward, suggesting a mechanism
that may contribute to the high rate of comorbidity between
anxiety and anhedonia (Southwick et al., 2005). Notably, this
effect was only observed in the subset of subjects who were
most responsive to the anxiety induction (i.e., threat of noxious electric shock). Given evidence that many individuals will
never experience a mood or anxiety disorder (Kessler et al.,
2012), this paradigm may provide a means of identifying those
at greatest risk. Methodologically, this observation underscores
the necessity of including independent measures of emotion
in studies of emotioncognition interactions (Shackman et al.,
2006).
HOW DOES COGNITION INFLUENCE AND REGULATE

EMOTION?
Humans frequently regulate their emotions and they do so using a
variety of implicit and explicit cognitive strategies (Gross, 1998a,b;
Gross and Thompson, 2007; Gross et al., 2011; Webb et al., 2012;
Okon-Singer et al., 2013). Implicit strategies are unintentional and
appear to occur without effort or insight. In contrast, explicit
strategies are voluntary and demand a degree of effortful control.
Several contributors to our Special Research Topic described
new insights into the mechanisms supporting the cognitive regulation of emotion and the role of emotion regulation in psychiatric
disorders, such as depression.
ATTENTION REGULATES EMOTION
Perhaps the most basic strategy for reducing distress is attentional

avoidance; that is, to simply look away from the source of distress
(Xing and Isaacowitz, 2006). Overt attentional redeployment is a
potent means of regulating the engagement of subcortical structures, such as the amygdala, that play a key role in orchestrating
emotional states (Pessoa et al., 2002; Dalton et al., 2005; Dalton
et al., 2007; van Reekum et al., 2007; Urry, 2010; Okon-Singer
et al., 2014a).
Here, Aue et al. (2013b) employed an innovative combination of eyetracking, psychophysiology, and fMRI to explore
visual avoidance in spider phobics. Taking an individual differences approach, they demonstrate that enhanced activation in
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Okon-Singer et al.
the amygdala and dorsal striatum to spider images was predictive

of increased visual avoidance among arachnophobes. Peripheral
measures of autonomic arousal showed a similar pattern, suggesting that arachnophobes endogenously redirect attention as a
means of regulating their extreme fear, a strategy that might be
non-adaptive in the long term (Grupe and Nitschke, 2013). A key
challenge for future research will be to clarify the order of these
effects (i.e., fear attention avoidance reduced fear), perhaps by leveraging the millisecond temporal resolution afforded by
facial electromyography (e.g., Lee et al., 2009; Heller et al., 2014).
Elucidating the mechanisms supporting the recursive interplay
of emotion and attention and the mutual inuences of different
processing biases (Aue et al., 2013a) would inform our understanding of disorders, like post-traumatic stress, that are characterized
by dysregulated emotion and aberrant attention to emotionallysalient cues (e.g., Admon et al., 2013; Wald et al., 2013) and set
the stage for developing improved interventions (MacLeod and
Mathews, 2012; Bar-Haim and Pine, 2013; MacLeod and Clarke,
2015).
THE CHOICE OF COGNITIVE REGULATION STRATEGY DEPENDS ON THE
SITUATION
Sheppes and Levin (2013) emphasize that humans frequently use

effortful cognitive strategies to cope with and regulate their emotions (e.g., Egloff et al., 2006; Ehring et al., 2010). For example,
they may try to distract themselves or they may try to reappraise
the situation in a more positive light. Sheppes and Levin (2013)
provide evidence that not only do individuals have the capacity
to exibly choose emotion regulation strategies, but that they do
so in ways that are strongly inuenced by the emotional context
(e.g., choosing to reappraise when presented with mild negative pictures, and to distract themselves in face of highly aversive
stimulation).
WORKING MEMORY REGULATES EMOTION
Some strategies for regulating emotional distress, such as reappraisal, require the effortful maintenance of an explicit regulatory
goal. Rolls (2013) reviews evidence suggesting that this critically
depends on working memory. More broadly, he suggests that goals,
attentional sets, and other kinds of declarative knowledge held in
working memory play a central role in regulating the output of
emotional systems.
HOW ARE EMOTION AND COGNITION INTEGRATED?

Humans tend to experience cognition and emotion as fundamentally different. Emotion is infused with feelings of pleasure or pain and manifests in readily discerned changes in
the body, whereas cognition often appears devoid of substantial hedonic, motivational, or somatic features. These apparent
differences in phenomenological experience and peripheral physiology led many classical scholars to treat emotion and cognition
as distinct mental faculties (de Sousa, 2014; Schmitter, 2014).
But contemporary theorists have increasingly rejected the claim
that emotion and cognition are categorically different (Damasio, 2005b; Duncan and Barrett, 2007; Lindquist and Barrett,
2012; Barrett and Satpute, 2013; Pessoa, 2013), motivated in
part by recent imaging evidence demonstrating the overlap of
emotional and cognitive processes in the brain (e.g., Shackman

et al., 2011b; Raz et al., 2012, 2014). The neural integration of
emotion and cognition should not be surprisingafter all, the
human brain did not evolve to optimize performance on laboratory measures of cold cognition or to passively respond
to experimental manipulations of emotion, such as threat of
shock. Our brain, like that of other animals, is the product
of evolutionary pressures that demanded neural systems capable of using information about pleasure and pain, derived from
stimuli saturated with hedonic and motivational signicance,
to adaptively regulate attention, learning, somatic arousal, and
action.
A number of contributors highlighted advances in our understanding of the neural mechanisms that serve to integrate emotion
and cognition.
CANONICAL TERRITORIES OF THE COGNITIVE BRAIN REGULATE
EMOTION
The dorsolateral prefrontal cortex (dlPFC) is a canonically cognitive region of the brain, well known for its critical role in reasoning
and higher cognition (e.g., endogenous attention, working memory, and cognitive control; Roberts et al., 1998; Miller and Cohen,
2001; DEsposito and Postle, 2014). Yet, there is growing evidence
that the dlPFC plays a key role in the topdown control of emotion and motivated behavior (Fox et al., 2005b; Koenigs et al., 2008;
Zaretsky et al., 2010; Buhle et al., 2013; Frank et al., 2014; Treadway
et al., 2014).
Here, Clarke and Johnstone (2013) and Iordan et al. (2013) provide tantalizing, albeit correlational, evidence that dlPFC acts to
protect the contents of working memory from emotional distraction. This converges with work by Peers et al. (2013) and Stollstorff
et al. (2013) indicating that dlPFC plays a key role in regulating the
focus of attention in the face of potentially distracting emotional
cues.
Rolls (2013) extends this perspective to decision-making, arguing that behavior reects a pervasive, dynamic competition
between two kinds of brain systems: (a) emotional systems, including circuits centered on the amygdala and ventral striatum, that
have been genetically programmed by our phylogenetic history
(e.g., fear elicited by danger, joy elicited by sweets and fat); and
(b) cognitive systems, such as the frontoparietal network, that are
informed by our ontogenetic history and governed by our declarative knowledge and explicit goals (i.e., pick the healthy orange,
not the unhealthy candy bar; cf. Hare et al., 2008, 2009). Rolls
emphasizes that the lateral PFC can override the output of emotion circuitry, biasing behavior in favor of our explicit goals. John
et al. (2013) articulate a complementary perspective, reviewing
evidence that the PFC and amygdala functionally interact via a
complex anatomical network of recurrent cortical and thalamic
projections and intra-amygdalar microcircuits (see also Pessoa and
Adolphs, 2010; Pessoa, 2012; Pessoa et al., 2012; Birn et al., 2014a,b;
Treadway et al., 2014).
Evidence linking the dlPFC to mood and anxiety disorders, as
in the papers contributed by Crocker et al. (2013) and Warren et al.
(2013), underscores the importance of developing a more sophisticated understanding of the role played by cognitive regions in
normal and disordered emotion.
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Okon-Singer et al.
CANONICAL TERRITORIES OF THE COGNITIVE BRAIN ARE REGULATED

BY EMOTION
Regulation is a two-way street. Just as cognitive systems (e.g.,

dlPFC) regulate emotion, emotion systems (e.g., amygdala) are
well positioned to regulate cognitive systems via their inuence over the brainstem neurotransmitter systems that govern
the quality of information processing (e.g., neuronal signal-tonoise) in cortical regions, as highlighted in the review contributed
by Shansky and Lipps (2013). Via these mechanisms, the amygdala is endowed with the capacity to transiently assume enhanced
control over attention and behavior in situations that favor immediate responses over slower, more deliberate reasoning (Davis and
Whalen, 2001; Arnsten, 2009).
ADAPTIVE AND MALADAPTIVE BEHAVIOR REFLECTS THE INTEGRATED
CONTRIBUTIONS OF EMOTION AND COGNITIVE CONTROL
Oftentimes, cognitive control is associated with laboratory tasks

that require the detection and adjudication of response conict,
as with incongruent trials of the Stroop, Eriksen Flanker, and
go/no-go tasks. Yet, it is clear that control processes are engaged
by a much broader range of cognitive and emotional challenges
(e.g., Pochon et al., 2008; Shenhav et al., 2013). In particular,
control is engaged when there is uncertainty about the optimal
course of action (e.g., probabilistic learning), when potential
actions are associated with the possibility of error or punishment, or when there is competition between alternative courses
of action (e.g., ee/freeze, go/no-go). These features are hallmarks of dangerous environments, both in the real world and
in laboratory studies of fear, anxiety, and pain. Consequently,
it has long been thought that control processes are engaged in
threatening environments in order to monitor risk, optimize
learning, and avoid potentially catastrophic actions (Norman and
Shallice, 1986; Gray and McNaughton, 2000). These theoretical
considerations raise the possibility that the neural circuitry underlying cognitive control also contributes to the negative emotions
elicited by potential threat. Indeed, there is compelling evidence
from functional imaging studies that negative affect and cognitive control paradigms consistently activate an overlapping region
of the midcingulate cortex (MCC; Shackman et al., 2011b; Lin
et al., 2014). This overlap is consistent with anatomical evidence
suggesting that the MCC represents a hub where information
about pain, threat, and other more abstract forms of potential
punishment and negative feedback are synthesized into a biasing signal that modulates regions involved in expressing fear
and anxiety, executing goal-directed behaviors, and biasing the
focus of selective attention (Shackman et al., 2011b; Cavanagh
and Shackman, 2014). Taken together, these observations suggest that anxiety and other emotions are tightly integrated with
control processes implemented in the MCC and other brain
regions.
Along these lines, Morrison et al. (2013) show that even simple, phylogenetically-ancient kinds of motivated behavior, such
as the reexive withdrawal from pain or the learned avoidance
of pain-related contexts, are dynamically shaped by complex,
hierarchically-organized networks of feedforward and feedback
connections that serve to integrate emotional (e.g., value, risk)
and cognitive computations (e.g., prediction error, attention
allocation, action selection) in ways that support adaptive behavior (for convergent perspectives, see the contributions from Rolls,
2013, and John et al., 2013).
Dreisbach and Fischer (2012) describe other evidence consistent with this integrative perspective. In particular, they show that
cognitive conict is aversive. This converges with a growing body
of evidence demonstrating that conict and other prompts for
increased control (e.g., errors, punishment), are experienced as
unpleasant and facilitate avoidance (Botvinick, 2007; Kool et al.,
2010; Dreisbach and Fischer, 2012; Schouppe et al., 2012; Lindstrm et al., 2013; Proudt et al., 2013; Shenhav and Buckner,
2014).
If negative emotions are indeed integrated with control processes, we would expect that anxiety and control should covary.
That is, one would expect a degree of functional convergence
between measures of anxiety and control-related activity in the
MCC or other regions (i.e., convergent validity; Campbell and
Fiske, 1959). Consistent with this possibility, Moser et al. (2013)
provide compelling meta-analytic evidence that error-related signals generated in the MCC are enhanced among anxiety patients
and individuals with heightened negative emotionality. This indicates that negative emotionality, a fundamental dimension of
childhood temperament and adult personality (Caspi et al., 2005),
involves systematic differences in the way that the brain responds
to prompts for cognitive control.
McDermott et al. (2013) describe important new evidence,
gleaned from the study of Romanian orphans, that MCC control signals are plastic. In particular, they demonstrate that
MCC-generated control signals are profoundly shaped by early
experience in ways that confer risk or resilience for later socioemotional problems. This underscores the need to clarify the
neurodevelopmental mechanisms that serve to integrate emotion
and cognition in the laboratory and in daily life.
UNDERSTANDING THE INTERPLAY OF EMOTION AND

COGNITION: STRATEGIES FOR FUTURE RESEARCH
Despite substantial progress, a number of important questions
about the interaction of emotion and cognition remain unanswered. In this nal section, we highlight three strategies for
enhancing research in the cognitive-affective sciences (for more
general recommendations about best research practices, see
Button et al., 2013a,b,c; David et al., 2013; Chalmers et al., 2014;
Ioannidis et al., 2014a,b).
UNDERSTANDING THE SIGNIFICANCE OF EMOTIONAL-COGNITION
INTERACTIONS IN THE LABORATORY REQUIRES MORE SOPHISTICATED
MEASURES OF BEHAVIOR IN THE REAL WORLD
Most investigations of emotion, cognition, and their interplay

rely on a small number of well-controlled, but highly articial
paradigms for manipulating emotion and cognition (e.g., static
aversive images and threat of shock to elicit anxiety; Coan and
Allen, 2007). Although these methods have afforded a number
of critical insights, their real-world signicance remains poorly
understood. For example, are attentional biases to threat, as
indexed by the dot-probe or other laboratory assays, predictive of
elevated behavioral inhibition or distress in daily life? Is amygdala
activation to fearful faces predictive of heightened social reticence
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Okon-Singer et al.
or risk avoidance outside the scanner (see Admon et al., 2009

for preliminary afrmative evidence)? Does the eliciting stimulus
(e.g., faces or aversive images) matter? Are measures of functional
connectivity or network-based metrics (e.g., node centrality; cf.
McMenamin et al., 2014) more predictive than regional activation
of behavior in the real world?
Given the limitations of ambulatory measures of brain
activitythere is no fMRI helmet as yetaddressing these fundamental questions requires pairing assays of brain and behavior
obtained in the laboratory with measures of thoughts, feelings,
and behavior obtained in the eld. Recent work combining fMRI
with ecological momentary assessment (EMA) techniques, in
which surveys are repeatedly delivered to participants mobile
devices, highlights the value of this approach for identifying the
neural systems underlying naturalistic variation in mood and
behavior, a central goal of psychology, psychiatry, and the behavioral neurosciences (Forbes et al., 2009; Berkman and Falk, 2013;
Lopez et al., 2014; Wilson et al., 2014). The widespread dissemination of smart phone technology affords additional, largely
unrealized opportunities for objectively and unobtrusively quantifying daily behavior (e.g., assessments of activity and context
based on accelerometer and geographical positioning system data
(Gosling and Mason, 2015). In short, combining EMA with laboratory assays provides a critical means of testing theoretical
validity and clinical relevance (e.g., does activation of the ventral striatum support craving and approach?), a novel strategy for
assessing and dissociating the functional signicance of new assays
and derivative measures (e.g., functional connectivity between
the striatum and PFC), and an impetus for the development
of laboratory probes that more closely resemble the challenges
we routinely encounter in life (e.g., appetitive social cues and
temptations).
UNDERSTANDING THE INTERPLAY OF EMOTION AND COGNITION
REQUIRES A DYNAMIC NETWORK PERSPECTIVE
Emotion and cognition emerge from the dynamic interactions of

large-scale brain networks. Put simply, fear, joy, attention, working
memory, and other psychological constructs cannot be mapped to
isolated brain regions because no one region is both necessary and
sufcient. Likewise, similar proles of impairment can emerge
from damage to different regions located within in the same functional network (Karnath and Smith, 2014; Oler et al., in press). This
is not a new or contentious idea; pioneers like Mesulam, GoldmanRakic, and LeDoux highlighted the importance of distributed
neural circuits more than two decades ago and there is widespread
agreement amongst basic and translational researchers (GoldmanRakic, 1988; LeDoux, 1995; Mesulam, 1998; Bullmore and Sporns,
2012; LeDoux, 2012; Uhlhaas and Singer, 2012; Anticevic et al.,
2013).
Thus, understanding the interplay of emotion and cognition requires that we accelerate the transition from localization strategies (i.e., mapping isolated brain structures to function; sometimes termed neo-phrenology) to a network-centered
approach. This will require harnessing the kinds of analytic
tools (e.g., functional connectivity ngerprinting, graph-theoretic
and machine-learning approaches) that are necessary for elucidating how adaptive and maladaptive behavior emerges from
functional coalitions of brain regions (Kinnison et al., 2012; Raz

et al., 2012, 2014; Anticevic et al., 2013; McMenamin et al., 2014;
Uddin et al., 2014). A key challenge for future research will
be to harness new techniques (e.g., EEG/fMRI fusions, sliding window analyses of functional connectivity, EEG source
models of connectivity) for understanding how network activity dynamically changes across the broad range of time scales
on which emotion and cognition interact (Pessoa and Adolphs,
2010; Shackman et al., 2011a; Johnson et al., 2012; Raz et al., 2012,
2014).
Computationally explicit strategies (i.e., where quantitative
parameters of an abstract computational model are t to behavioral or physiological measures), already common in the neuroeconomics literature, and information-based approaches, such as
multivoxel pattern analysis (MVPA), that are increasingly common in the cognitive neuroscience literature, provide powerful
tools for discovering the functional signicance of regions and
networks associated with emotional and cognitive perturbations
and disorders (e.g., Hartley and Phelps, 2012; Montague et al.,
2012; Lewis-Peacock and Norman, 2013). For example, traditional univariate fMRI analyses use regression to predict the
activity of voxels, one-by-one, given some mental state (e.g.,
experiencing pain). While this strategy has proven enormously
generative, it does not provide strong evidence as to whether
overlapping patterns of fMRI activation (e.g., during physical
and social pain; Wager et al., 2013; Woo et al., 2014) reect
the same mental representation. MVPA provides a means of
addressing this problem. MVPA classies mental states given a
pattern of activity across voxels; in effect, treating each voxel
as a weighted source of information about mental state. This
contributes to the identication of the combinatorial code (i.e.,
pattern of activity across voxels) instantiating a particular mental state (e.g., experiencing anxiety) and to test whether that
neural signature is reinstated at other times (e.g., performing a
cognitive control task), an essential step in elucidating the functional contributions of territories that are commonly recruited by
cognitive and emotional challenges (e.g., dlPFC, MCC, anterior
insula).
Embracing a network perspective also reminds us that the functional circuitry underlying the interplay of emotion and cognition
is likely to be complex and need not recapitulate the simpler pattern of direct projections revealed by invasive anatomical tracing
techniques [cf. the contributions from John et al. (2013), Morrison et al. (2013), and Rolls (2013)]. Indeed, there is ample evidence
of robust functional connectivity between brain regions that lack
direct structural connections and increasing evidence that regulatory signals can rapidly propagate across complex, indirect
pathways in ways that enable emotion (e.g., motivational salience
or value) to be integrated with perception and other kinds of
on-going information processing (Vincent et al., 2007; Ekstrom
et al., 2008; Honey et al., 2009; Pessoa and Adolphs, 2010; Adachi
et al., 2012; Birn et al., 2014a). Deciphering the functional signicance of this connectomic complexity is likely to require more
advanced analytic approaches, such as probabilistic machinelearning techniques (Murphy, 2012). The combination of ongoing
advances in computational methods as well as developments in
brain imaging acquisition techniques (e.g., those supported by
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Okon-Singer et al.
the U.S. BRAIN initiative) will undoubtedly contribute to these

efforts.
UNDERSTANDING THE INTERPLAY OF EMOTION AND COGNITION
REQUIRES MECHANISTIC RESEARCH
Most of the contributors to the Special Research Topic used noninvasive techniques, such as fMRI, to trace associations between
emotion and cognition, on the one hand, and brain function
on the other. Aside from unresolved questions about the origins and signicance of the measured signals (e.g., Logothetis,
2008), the most important limitation of these techniques is that
they do not address causation. A crucial challenge for future
studies is to develop a mechanistic understanding of the distributed networks that support the interplay of emotion and
cognition. This can be achieved by combining mechanistic techniques (e.g., optogenetics) or invasive analyses of neuromolecular
pathways in animal models with the same whole-brain imaging
strategies routinely applied in humans (Borsook et al., 2006; Lerman et al., 2007; Fox et al., 2010, 2012; Lee et al., 2010; Desai
et al., 2011; Casey et al., 2013; Narayanan et al., 2013; Roseboom
et al., 2014). Similar strategies can be used with patients with
circumscribed brain damage (e.g., Nomura et al., 2010; Gratton et al., 2012; Motzkin et al., 2014). Combining fMRI or EEG
with non-invasive perturbation techniques (e.g., transcranial magnetic stimulation or transcranial direct current stimulation) or
pharmacological manipulations provides another opportunity for
understanding how regional changes in brain activity alter network function and, ultimately, behavior (Paulus et al., 2005;
Guller et al., 2012; Chen et al., 2013; Reinhart and Woodman,
2014). Prospective longitudinal designs represent another fruitful
approach to identifying candidate mechanisms, especially in relation to the development of neuropsychiatric disorders (Admon
et al., 2013).
CONCLUSION
The last decade has witnessed an explosion of interest in the interplay of emotion and cognition. The research embodied in this
Special Research Topic highlights the tremendous advances that
have already been made. In particular, this work demonstrates
that emotional cues, emotional states, and emotional traits can
strongly inuence key elements of on-going information processing, including selective attention, working memory, and cognitive
control. Often, this inuence persists beyond the duration of
transient emotional challenges, perhaps reecting slower changes
in neurochemistry. In turn, circuits involved in attention and
working memory contribute to the voluntary regulation of emotion. The distinction between the emotional and the cognitive
brain is blurry and context-dependent. Indeed, there is compelling evidence that territories (e.g., dlPFC, MCC) and processes
(e.g., working memory, cognitive control) conventionally associated with cognition play a central role in emotion. Furthermore,
putatively emotional and cognitive regions dynamically inuence one another via a complex web of recurrent, often indirect
anatomical connections in ways that jointly contribute to adaptive behavior. Collectively, these observations show that emotion
and cognition are deeply interwoven in the fabric of the brain,
suggesting that widely held beliefs about the key constituents of
the emotional brain and the cognitive brain are fundamentally

awed.
Developing a deeper understanding will require a greater
emphasis on (a) assessing the real-world relevance of laboratory assays, including measures of brain activity; (b) a network approach to characterizing the neurobiology of emotion
cognition interactions, and (c) mechanistic research. Adopting
these strategies mandates collaboration among researchers from
different disciplines, with expertise in different species, populations, measurement tools, analytic strategies, and conceptual
approaches.
Addressing the interplay of emotion and cognition is a matter of
theoretical as well as practical importance. In particular, many of
the most common and costly neuropsychiatric disordersanxiety,
depression, schizophrenia, substance abuse, chronic pain, autism,
and so oninvolve prominent disturbances of cognition and
emotion (Millan, 2013). Fundamentally, they are disorders of the
emotional-cognitive brain. Collectively, these disorders far outstrip the global burden of cancer or cardiovascular disease (Collins
et al., 2011; Whiteford et al., 2013; DiLuca and Olesen, 2014),
underscoring the importance of accelerating efforts to understand
the neural systems underlying the interaction and integration of
emotion and cognition.
GLOSSARY OF TERMS NOT DEFINED IN THE MAIN TEXT

Affect: The experience or expression of emotion (see also Barrett
et al., 2007).
Anxiety: A sustained state of heightened apprehension in response
to uncertain, distal, or diffuse threat (Davis et al., 2010).
Cognition: Cognition is a fuzzy category that conventionally
includes processes involved in knowing or thinking, including
attention, imagination, language, learning, memory, and perception (for discussion, see Duncan and Barrett, 2007).
Emotion: Like cognition, emotion is a fuzzy, contentious category that conventionally includes valenced processes (e.g., action
tendencies, attention, overt behavior, subjective feelings, and alterations in peripheral physiology) that are triggered by specic
external or internal stimuli (e.g., actual or remembered threat for
fear); often taken to include states of anger, disgust, fear, happiness, and sadness (e.g., Ekman and Davidson, 1994; Duncan and
Barrett, 2007; Gendron and Barrett, 2009; LeDoux, 2012, 2014).
Mood: A low-intensity emotional state that persists in the absence
of an explicit triggering stimulus (Ekman and Davidson, 1994).
Motivation: Internal states that are elicited by reinforcers and
serve to organize behavioral direction (i.e., approach or avoidance)
and intensity. Emotional states involve alterations in motivation
(e.g., increased avoidance in the case of fear). However, motivation can be altered by homeostatic processes, such as hunger
and satiety, that are not conventionally considered emotional
(Rolls, 1999).
Neuroticism/Negative Emotionality: A fundamental dimension
of childhood temperament and adult personality; individuals with
high levels of Neuroticism/Negative Emotionality are susceptible
to more intense or long-lasting negative emotions, including anger,
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Okon-Singer et al.
anxiety, fear, guilt, and sadness (Watson and Clark, 1984; Caspi
et al., 2005).
Reinforcer: Rewards and punishments; anything an organism will
work to approach or avoid (Rolls, 1999).
AUTHOR CONTRIBUTIONS
All the authors supervised the Special Research Topic. Hadas
Okon-Singer and Alexander J. Shackman wrote the paper. All the
authors edited and revised the paper.
ACKNOWLEDGMENTS
We thank the many contributors and staff who made the Special
Research Topic possible. We acknowledge the assistance of L.
Friedman and support of the European Commission (Followship #334206 to Hadas Okon-Singer and Grant #602186 to Talma
Hendler), Israeli Center of Research Excellence, Israeli Science
Foundation (Grant #51/11 to Talma Hendler), National Institute
of Mental Health (MH071589 to Luiz Pessoa), and University of
Maryland (Alexander J. Shackman and Luiz Pessoa).
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Conflict of Interest Statement: The authors declare that the research was conducted
in the absence of any commercial or nancial relationships that could be construed
as a potential conict of interest.
Received: 14 November 2014; accepted: 21 January 2015; published online: 17
February 2015.
Citation: Okon-Singer H, Hendler T, Pessoa L and Shackman AJ (2015) The neurobiology of emotioncognition interactions: fundamental questions and strategies for future
research. Front. Hum. Neurosci. 9:58. doi: 10.3389/fnhum.2015.00058
This article was submitted to the journal Frontiers in Human Neuroscience.
Copyright 2015 Okon-Singer, Hendler, Pessoa and Shackman. This is an openaccess article distributed under the terms of the Creative Commons Attribution License
(CC BY). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution or
reproduction is permitted which does not comply with these terms.
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published: 17 February 2015

The neurobiology of emotioncognition interactions:

Department of Psychology, University of Haifa, Haifa, Israel

authors have contributed

Frontiers in Human Neuroscience

of the science will motivate new and impactful research. Clearly,

HOW DOES EMOTION INFLUENCE COGNITION?

There is abundant evidence that emotionally-salient cues

February 2015 | Volume 9 | Article 58 | 1

Frontiers in Human Neuroscience

ATTENTIONAL BIASES TO EMOTIONAL CUES ARE PLASTIC

Anxious individuals tend to allocate excess attention to threat and

Emotions are often conceptualized as eeting and most imaging

February 2015 | Volume 9 | Article 58 | 2

cognition and behavior (Davidson, 2004; Suls and Martin, 2005;

Endogenous attention is tightly linked with working memory

Frontiers in Human Neuroscience

DISTRACTING EMOTIONAL CUES DISRUPT COGNITIVE CONTROL AND

February 2015 | Volume 9 | Article 58 | 3

et al. (2013) review human imaging studies showing that the

Moods and other, more transient emotional states tend to

Frontiers in Human Neuroscience

can inuence cold cognition (Shackman et al., 2006; Eysenck

HOW DOES EMOTION INFLUENCE EMOTION?

Building on earlier work by Bogdan and Pizzagalli (2006),

HOW DOES COGNITION INFLUENCE AND REGULATE

Perhaps the most basic strategy for reducing distress is attentional

February 2015 | Volume 9 | Article 58 | 4

the amygdala and dorsal striatum to spider images was predictive

Sheppes and Levin (2013) emphasize that humans frequently use

HOW ARE EMOTION AND COGNITION INTEGRATED?

Frontiers in Human Neuroscience

emotional and cognitive processes in the brain (e.g., Shackman

February 2015 | Volume 9 | Article 58 | 5

CANONICAL TERRITORIES OF THE COGNITIVE BRAIN ARE REGULATED

Regulation is a two-way street. Just as cognitive systems (e.g.,

Oftentimes, cognitive control is associated with laboratory tasks

Frontiers in Human Neuroscience

UNDERSTANDING THE INTERPLAY OF EMOTION AND

Most investigations of emotion, cognition, and their interplay

February 2015 | Volume 9 | Article 58 | 6

or risk avoidance outside the scanner (see Admon et al., 2009

Emotion and cognition emerge from the dynamic interactions of

Frontiers in Human Neuroscience

functional coalitions of brain regions (Kinnison et al., 2012; Raz

February 2015 | Volume 9 | Article 58 | 7

the U.S. BRAIN initiative) will undoubtedly contribute to these

Frontiers in Human Neuroscience

the emotional brain and the cognitive brain are fundamentally

GLOSSARY OF TERMS NOT DEFINED IN THE MAIN TEXT

February 2015 | Volume 9 | Article 58 | 8

Frontiers in Human Neuroscience

February 2015 | Volume 9 | Article 58 | 9

neuroimaging studies. Cereb. Cortex 24, 29812990. doi: 10.1093/cercor/

Frontiers in Human Neuroscience

February 2015 | Volume 9 | Article 58 | 10

Frontiers in Human Neuroscience

Hartley, C. A., and Phelps, E. A. (2012). Anxiety and decision-making. Biol.