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Inhibition of Lung Cancer

Growth: ATP Citrate Lyase
Knockdown and Statin Treatment
Leads to Dual Blockade of
Mitogen-Activated Protein
Kinase (MAPK) and
Phosphatidylinositol-3-Kinase
(PI3K)/AKT Pathways
JUN-ICHI HANAI,1,2 NATHANIEL DORO,1 ATSUO T. SASAKI,4,5 SUSUMU
KOBAYASHI,3
LEWIS C. CANTLEY,4,5 PANKAJ SETH,1
AND VIKAS P. SUKHATME1,2,3*
Inhibition of Lung Cancer

Growth: ATP Citrate Lyase
Knockdown and Statin Treatment
Leads to Dual Blockade of
Mitogen-Activated Protein
Kinase (MAPK) and
Phosphatidylinositol-3-Kinase
(PI3K)/AKT Pathways
JUN-ICHI HANAI,1,2 NATHANIEL DORO,1 ATSUO T. SASAKI,4,5 SUSUMU
KOBAYASHI,3
LEWIS C. CANTLEY,4,5 PANKAJ SETH,1
AND VIKAS P. SUKHATME1,2,3*
Statins as modulators of colon cancer cells induced cytokine

secretion by
human PBMC
Michael Bergman
a,c,
Hertzel Salman
a,c,
Meir Djaldetti
b,c,
, Hanna Bessler b,c
Statin therapy attenuates growth and malignant potential

of human
esophageal adenocarcinoma cells
Miral R. Sadaria, MD, Amy E. Reppert, MD, Jessica A. Yu, MD, Xianzhong Meng, MD,
PhD,
David A. Fullerton, MD, T. Brett Reece, MD, and Michael J. Weyant, MD
Simvastatin inhibition of mevalonate pathway induces apoptosis in

human
breast cancer cells via activation of JNK/CHOP/DR5 signaling
pathway
Archana Gopalan
a,1,
Weiping Yu
b,1,
Bob G. Sanders b, Kimberly Kline a,
Simvastatin Induces Apoptosis in Castrate Resistant

Prostate
Cancer Cells by Deregulating Nuclear Factor-_B Pathway
Yong Hyun Park, Su Yeon Seo, Eunhye Lee, Ja Hyeon Ku, Hyeon Hoe Kim* and
Cheol Kwak*
Effects of statins and farnesyl transferase inhibitors on ERK

phosphorylation,
apoptosis and cell viability in non-small lung cancer cells
G. Pelaia*, L. Gallelli, T. Renda*, D. Fratto, D. Falcone, M. Caraglia, M. T. Busceti*, R.
Terracciano,
A. Vatrella, R. Maselli* and R. Savino
Statins and autoimmunity

Saakshi Khattri Gisele Zandman-Goddard
Regulation of mevalonate metabolism in cancer and immune cells

Q13 Martin
Thurnher , Georg Gruenbacher, Oliver Nussbaumer
Targeting protein prenylation for

cancer therapy
Norbert Berndt*, Andrew D. Hamilton and Sad M. Sebti*
Pleiotropic Effects of Statins

Basic Research and Clinical Perspectives
Qian Zhou, MD; James K. Liao, MD
Anti-atherosclerotic mechanisms of statin therapy Andrea

Babelova1, Daniel G Sedding2 and Ralf P Brandes1
Targeting tumor cell metabolism with statins

JW Clendening and LZ Penn
Receptor Mediated Tumor Targeting: An Emerging Approach for

Cancer
Therapy
Chandana Mohanty1, Manasi Das1, Jagat R. Kanwar2 and Sanjeeb K. Sahoo1,*
Deciphering the signaling networks underlying

simvastatin-induced apoptosis in human cancer
cells:
evidence for non-canonical activation of RhoA and
Rac1 GTPases
Y Zhu1,2, PJ Casey3,4, AP Kumar5,6,7,8 and S Pervaiz*,1,2,4,6,8,9
Reduction of lung metastasis, cell

invasion, and
adhesion in mouse melanoma by
statin-induced
blockade of the Rho/Rho-associated
coiled-coilcontaining
protein kinase pathway
Yasuhiro Kidera1,2, Masanobu Tsubaki1, Yuzuru Yamazoe1,2, Kaori Shoji3, Haruyuki

Nakamura3, Mitsuhiko Ogaki3,
Takao Satou4, Tatsuki Itoh4, Misako Isozaki1,2, Junichi Kaneko1, Yoshihiro Tanimori1,2,
Masashi Yanae1,5,
Shozo Nishida1*
Mini-review
Molecular mechanisms underlying chronic inflammation-associated

cancers
Yongzhong Wua, Smitha Antony a, Jennifer L. Meitzler a, James H. Doroshow
a,b,
Combating oxidative stress in

vascular disease: NADPH oxidases as
therapeutic targets
*Grant R. Drummond, *Stavros Selemidis, Kathy K. Griendling and *Christopher G.
Sobey
Simvastatin inhibits osteoclast differentiation by

scavenging
reactive oxygen species
Ho-Jin Moon1, Sung Eun Kim1, Young Pil Yun1,
Yu-Shik Hwang1, Jae Beum Bang2,
Jae-Hong Park3,4* and Il Keun Kwon1,4*
Far and Wide Pleiotropic Effects of Statins

A. Rohilla1* and MU. Khan2
Effects of statin use on total oxidant

and antoxidant
capacity and ceruloplasmin activity
Statins: protectors or pretenders

in prostate cancer? Hyeongsun Moon , Michelle
1
M. Hill1, Matthew J. Roberts2,3,4, Robert A. Gardiner2,3, and Andrew J.

Brown5
Reduction of lung metastasis, cell

invasion, and
adhesion in mouse melanoma by
statin-induced
blockade of the Rho/Rho-associated
coiled-coilcontaining
protein kinase pathway
Yasuhiro Kidera1,2, Masanobu Tsubaki1, Yuzuru Yamazoe1,2, Kaori Shoji3, Haruyuki
Nakamura3, Mitsuhiko Ogaki3,
Takao Satou4, Tatsuki Itoh4, Misako Isozaki1,2, Junichi Kaneko1, Yoshihiro Tanimori1,2,
Masashi Yanae1,5,
Shozo Nishida1
Mechanisms for the anti-inflammatory effects of statins

De-xiu Bu, Gabriel Griffin and Andrew H. Lichtman
Antioxidant, antinociceptive and anti-inflammatory

activities
of atorvastatin and rosuvastatin in various experimental
models
Mahesh M. Ghaisas Prasad R. Dandawate
Suyash A. Zawar Yogesh S. Ahire
Santosh P. Gandhi
A Clinical Review of Statins and Cancer:

Helpful or Harmful?
Statins:
perspectives
in
Cancer
Therapeutics
Laurent
CORCOS
&
Catherine
LE
JOSSIC--CORCOS
A Clinical Evaluation of Statin Pleiotropy:

Statins
Selectively and Dose-Dependently Reduce
Vascular
Inflammation
Evelien van der Meij1, Giel G. Koning2, Patrick W. Vriens2, Marcel F. Peeters5, C. Arnoud
Meijer1,
Kim E. Kortekaas1,4, Ronald L. Dalman4, J. Hajo van Bockel1, Roeland Hanemaaijer3, Teake
Kooistra3,
Robert Kleemann3, Jan H. N. Lindeman1*
Statins as Regulators of Redox State

in the Vascular Endothelium:
Beyond Lipid Lowering
Marios Margaritis, Keith M. Channon, and Charalambos Antoniades

Abstract
Am J Cancer Res 2011;1(4):542-561

www.ajcr.us /ISSN:2156-6976/ajcr0000049
Review Article
Statins and prostate cancer: role of cholesterol
inhibition
vs. prevention of small GTP-binding proteins
Mohana Roy1, Hsing-Jien Kung2, Paramita M. Ghosh1,2
Overcoming multidrug-resistance in cancer: Statins offer a logical

candidate
Narendra G. Mehta
a,*,
Monica Mehta
b,1
Atorvastatin sensitizes human non-small cell lung carcinomas to

carboplatin via
suppression of AKT activation and upregulation of TIMP-1
Inhibition of Autophagy Enhances Anticancer Effects of

Atorvastatin in Digestive Malignancies
Pei-Ming Yang1, Yuan-Ling Liu1, Yi-Chu Lin1, Chia-Tung Shun2, Ming-Shiang Wu3, and Ching-Chow Chen1

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Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY.

Bob G. Sanders b, Kimberly Kline a,

C. Spampanato, M.S. De, M. Sarnataro, E. Giordano, M. Zanfardino, S. Baiano, M.

N. Ghosh-Choudhury, C.C. Mandal, N. Ghosh-Choudhury, G. Choudhury,

M. Thurnher, O. Nussbaumer, G. Gruenbacher, Novel aspects of mevalonate

Inhibition of Lung Cancer

Inhibition of Lung Cancer

Statins as modulators of colon cancer cells induced cytokine

, Hanna Bessler b,c

Statin therapy attenuates growth and malignant potential

Simvastatin inhibition of mevalonate pathway induces apoptosis in

Bob G. Sanders b, Kimberly Kline a,

Simvastatin Induces Apoptosis in Castrate Resistant

Effects of statins and farnesyl transferase inhibitors on ERK

Statins and autoimmunity

Regulation of mevalonate metabolism in cancer and immune cells

Thurnher , Georg Gruenbacher, Oliver Nussbaumer

Targeting protein prenylation for

Pleiotropic Effects of Statins

Anti-atherosclerotic mechanisms of statin therapy Andrea

Targeting tumor cell metabolism with statins

Receptor Mediated Tumor Targeting: An Emerging Approach for

Deciphering the signaling networks underlying

Reduction of lung metastasis, cell

Yasuhiro Kidera1,2, Masanobu Tsubaki1, Yuzuru Yamazoe1,2, Kaori Shoji3, Haruyuki

Molecular mechanisms underlying chronic inflammation-associated

Yongzhong Wua, Smitha Antony a, Jennifer L. Meitzler a, James H. Doroshow

Combating oxidative stress in

Simvastatin inhibits osteoclast differentiation by

Far and Wide Pleiotropic Effects of Statins

Effects of statin use on total oxidant

Statins: protectors or pretenders

M. Hill1, Matthew J. Roberts2,3,4, Robert A. Gardiner2,3, and Andrew J.

Reduction of lung metastasis, cell

Mechanisms for the anti-inflammatory effects of statins

Antioxidant, antinociceptive and anti-inflammatory

A Clinical Review of Statins and Cancer:

A Clinical Evaluation of Statin Pleiotropy:

Statins as Regulators of Redox State

Marios Margaritis, Keith M. Channon, and Charalambos Antoniades

Am J Cancer Res 2011;1(4):542-561

Overcoming multidrug-resistance in cancer: Statins offer a logical

Atorvastatin sensitizes human non-small cell lung carcinomas to

Inhibition of Autophagy Enhances Anticancer Effects of

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