International Unit: Vitamin A Vitamin C Vitamin D Vitamin E Insulin

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International unit

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In pharmacology, the international unit is a unit of measurement for the amount of a
substance; the mass or volume that constitutes one international unit varies based on
which substance is being measured, and the variance is based on the biological
activity or effect, for the purpose of easier comparison across substances. International
units are used to quantify vitamins, hormones, somemedications, vaccines, blood
products, and similar biologically active substances.
Many biological agents eist in different forms or preparations !e.g. vitamin " in the form
of retinol or beta #carotene $. %he goal of the I& is to be able to compare these, so that different forms or
preparations with the same biological effect will contain the same number of I&s. %o do so,
the W'( )pert *ommittee on +iological ,tandardi-ation provides a reference preparation of the
agent, arbitrarily sets the number of I&s contained in that preparation, and specifies a biological
procedure to compare other preparations of the same agent to the reference preparation. ,ince the
number of I&s contained in a new substance is arbitrarily set, there is no equivalence between I&
measurements of different biological agents. For instance, one I& of vitamin ) cannot be equated with
one I& of vitamin " in any way, including mass or efficacy.
Vitamin A: 1 IU is the biological equivalent of 0.3 g retinol, or of 0.6 g beta-
carotene
[6[!
Vitamin C: 1 IU is "0 g #-ascorbic aci$
Vitamin D: 1 IU is the biological equivalent of 0.0%"
g cholecalciferol&ergocalciferol
Vitamin E: 1 IU is the biological equivalent of about 0.66! 'g $-al(ha-
toco(herol )%&3 'g e*actl+,, or of 0.-" 'g of $l-al(ha-toco(herol acetate.
[.[/
Insulin: 1 IU is equivalent to 0.03-! 'g of hu'an insulin )%... IU&'g,.
.itamin "
/ I& 0 1.2 mcg all#trans retinal 0 1.2 mcg retinol 0 1.233 mcg retinyl acetate 0 1.44 mcg retinyl palmitate 0 2.5 mcg +eta#
*arotene
/ mcg 6etinol 0 2.23 I& of vitamin " activity
/ mg of all#trans +eta#*arotene 0 /557 I& of .itamin " activity
/ mcg +eta#*arotene 0 /.57 I& of .itamin " activity
/ mcg dietary +eta#*arotene 0 1./57 mcg retinal
6etinol )quivalents !6)$ 0 the .itamin " activity in foods / 6) 0 / mcg all#trans retinal 0 / mcg retinal 0 2.22 I& 6etinol /
6) 0 5 mcg all#trans +eta#*arotene 0 5 mcg +eta#*arotene / 6) 0 /8 mcg other provitamin " carotenoids
.itamin )
/ I& 0 1.57 mg of d#alpha#tocopherol or 1.34 dl#alpha#tocopherol
/ mg 0 /.39 I& d#alpha#tocopherol !natural vitamin ); 666#alpha#tocopherol$
/ mg 0 /./1 dl#alpha#tocopherol !synthetic vitamin ); all#rac#alpha#tocopherol$
.itamin :
/ I& 0 1.184 mcg of cholecalciferol !.itamin :2$
/ mcg .itamin : !cholecalciferol$ 0 31 I&

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