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    Pa Tho Physiology of Cholelithiasis

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    Nicol John Ceballos
    Gallstone formation, or cholelithiasis, can be influenced by both modifiable and non-modifiable risk factors. Non-modifiable factors include female sex, increasing age, genetics, and race. Modifiable risk factors are obesity, rapid weight loss, certain infections, prolonged fasting, and a high-fat diet. Gallstones form when bile contains high cholesterol levels, causing cholesterol crystals to form in the gallbladder. The crystals can then agglomerate into gallstones. Gallstones may lead to obstruction of the biliary tract and inflammation of the gallbladder known as cholecystitis.

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    Pa Tho Physiology of Cholelithiasis

    Uploaded by

    Nicol John Ceballos
    49 views2 pages
    Gallstone formation, or cholelithiasis, can be influenced by both modifiable and non-modifiable risk factors. Non-modifiable factors include female sex, increasing age, genetics, and race. Modifiable risk factors are obesity, rapid weight loss, certain infections, prolonged fasting, and a high-fat diet. Gallstones form when bile contains high cholesterol levels, causing cholesterol crystals to form in the gallbladder. The crystals can then agglomerate into gallstones. Gallstones may lead to obstruction of the biliary tract and inflammation of the gallbladder known as cholecystitis.

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    Gallstone formation, or cholelithiasis, can be influenced by both modifiable and non-modifiable risk factors. Non-modifiable factors include female sex, increasing age, genetics, and race. Modifiable risk factors are obesity, rapid weight loss, certain infections, prolonged fasting, and a high-fat diet. Gallstones form when bile contains high cholesterol levels, causing cholesterol crystals to form in the gallbladder. The crystals can then agglomerate into gallstones. Gallstones may lead to obstruction of the biliary tract and inflammation of the gallbladder known as cholecystitis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    49 views2 pages

    Pa Tho Physiology of Cholelithiasis

    Uploaded by

    Nicol John Ceballos
    Gallstone formation, or cholelithiasis, can be influenced by both modifiable and non-modifiable risk factors. Non-modifiable factors include female sex, increasing age, genetics, and race. Modifiable risk factors are obesity, rapid weight loss, certain infections, prolonged fasting, and a high-fat diet. Gallstones form when bile contains high cholesterol levels, causing cholesterol crystals to form in the gallbladder. The crystals can then agglomerate into gallstones. Gallstones may lead to obstruction of the biliary tract and inflammation of the gallbladder known as cholecystitis.

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    Download as DOC, PDF, TXT or read online from Scribd
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    Pathophysiology of Cholelithiasis

    Gall Bladder

    Etiologic Factor Non-Modifiable:


    Demographic/Genetic factor
    Female sex hormone
    Increasing age
    Bacterial Infection: Race: Asian
    staphylococcus,
    streptococcus Modifiable:
    organisnms. E. coli, Obesity
    typhoid bacillus Weight Loss
    Ileac Disease
    Pregnancy Fasting
    Prolonged parenteral nutrition
    Drugs (clofibrate)
    High calorie, high fat diet
    Chronic hemolysis
    Parasitic infestation

    Supersaturation of bile with cholesterol


    (Cholesterol concentration exceed the solubilizing
    capacity of bile)

    Gallbladder hypomotility promotes nucleation

    Cholesterol nucleation in bile is accelerated

    Mucus hypersecretion in the gallbladder traps the


    crystals, permitting their agglomeration into stones
    Gallstones

    May lead to obstruction

    Inflammation (cholecystitis)

    Frequent- Biliary Nausea/ -fever Leukocyto- hematuria An-


    ly colic/right vomiting -chills sis xiety
    asympto- upper appre-
    matic epigastric hen-
    (initial) pain, sion
    Murphy
    sign,
    abdominal
    tender-
    ness

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