Somazina Doc Info

SOMAZINA
COMPOSITION
Somazina 500 Injection
Each ampoule contains:
Citicholine sodium equivalent to Citocholine ---- 500 mg
Water for injection IP ………………………………...q.s. to 4ml
Somazina 1 g Injection
Each 4 ml ampoule contains:
Citicholine sodium equivalent to Citocholine ----250 mg/ml
Water for injection IP ……………………………………..q.s.
Somazina 500 mg Tablets

Each film-coated tablet contains:
Citicholine sodium equivalent to Citicholine ------500mg
Somazina 1 g Tablets
Each film-coated tablet contains:
Citicholine sodium equivalent to Citicholine ------1000 mg
DESCRIPTION
Citicoline (CDP-Choline) is a naturally occurring, water-soluble biological
compound that is an essential intermediate for the synthesis of
phosphatidylcholine, a major constituent of the gray matter of brain tissue.
Citicoline promotes brain metabolism by enhancing the synthesis of
acetylcholine and restoring phospholipid content in the brain.
Citicoline (CDP-Choline) is a naturally occurring, water-soluble biological

compound that is an essential intermediate for the synthesis of
phosphatidylcholine, a major constituent of the gray matter of brain tissue.
Citicoline promotes brain metabolism by enhancing the synthesis of
acetylcholine and restoring phospholipid content in the brain.
HIGHLIGHTS
§ Well defined multiple mode of action
§ Suitable pharmacokinetic properties and high safety
§ Highly compatible with first line drugs like rtPA
§ Good quality evidence base
CLINICAL PHARMACOLOGY
§ Citicholine activates the biosynthesis of structural
phospholipids in the neuronal cell membrane, increases
cerebral metabolism, and increases the levels of various
neurotransmitters, including acetylcholine and dopamine.
§ Citicholine has shown neuroprotective effects in situations of

hypoxia and ischaemia, as well as improved learning and
memory performance in brain aging.
§ Citicholine, through the action, improves the function of the

membrane mechanisms, such as the functioning of the ionic
exchange pumps and receptors inserted in it, the modulation
of which is indispensable for a correct neurotransmission.
§ Citicholine has cerebral antiedematous properties due to its

stabilizing action on the neuronal cell membrane.
§ Clinical trials have demonstrated that Citicholine improves the

symptoms associated with states of cerebral dysfunction
subsequent to various processes, such as the
carnioencephalic traumatism and acute cerebral vascular
accident. Citicholine improves the level of amnesia and the
cognitive, sensitive and motor disorders associated with these
pathologies. subsequent to various processes, such
as the carnioencephalic traumatism and acute cerebral vascular
accident. Citicholine improves the level of amnesia and the
cognitive, sensitive and motor disorders associated with these
pathologies.
INDICATIONS
Injections:
For the treatment of disturbance of consciousness resulting
from head injuries, brain operation and acute stage of cerebral
infarction.
Tablets:
For the treatment of patients with serious cerebral injuries of
vascular traumatic nature with or without loss of consciousness
and for treatment of degenerative damages and chronic cerebral
vascular injuries in senile dementia.
CONTRAINDICATIONS
Must not be administered to patients with hypertonia of the
parasympathetic.
PRECAUTIONS
Must not be administered in conjunction, with medications

containing centrophenoxine.
In case of persistent intracranial hemorrhage, it is
recommended not to exceed the dose of 1000 mg of Somazina
daily, in very slow intravenous administration (30
drops/minute).
ADVERSE REACTIONS
Occasionally Somazina may exert a stimulating action of the

parasympathetic, as well as discreet and fleeting hypotensive
effect.
DOSAGE AND ADMINISTRATION
Somazina Vial (1gm/4ml):
1 or 2 gms daily in divided doses or as prescribed by the

physician.
Somazina Vial (500 mg/4ml):
1 or 2 gms daily in divided doses or as prescribed by the
physician.
Somazina Tablets (500mg & 1g):

2 tablets daily or as prescribed by the physician.
To be kept out of the reach of children.
METHOD OF ADMINISTRATION
Somazina can be administered by intramuscular, slow
intravenous route (3 to 5 minutes) or in deep perfusion.
Somazina is compatible with all intravenous isotonic solutions,

it can also be mixed with hypertonic glucosed serum.
PRESENTATION
Somazina 500 mg Injection: 4ml Ampoule
Somazina 1gm Injection : 4ml Ampoule
Somazina 500 mg Tablet: Strip of 10 tablets
Somazina 1g Tablet: Strip of 10 tablets

Somazina Doc Info

Uploaded by

Copyright:

Available Formats

Somazina Doc Info

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Somazina Doc Info

Uploaded by

Copyright:

Available Formats

SOMAZINA

Somazina 500 mg Tablets

Citicoline (CDP-Choline) is a naturally occurring, water-soluble biological

§ Well defined multiple mode of action

§ Suitable pharmacokinetic properties and high safety

§ Highly compatible with first line drugs like rtPA

§ Good quality evidence base

§ Citicholine has shown neuroprotective effects in situations of

§ Citicholine, through the action, improves the function of the

§ Citicholine has cerebral antiedematous properties due to its

§ Clinical trials have demonstrated that Citicholine improves the

Must not be administered in conjunction, with medications

Occasionally Somazina may exert a stimulating action of the

1 or 2 gms daily in divided doses or as prescribed by the

Somazina Tablets (500mg & 1g):

To be kept out of the reach of children.

Somazina is compatible with all intravenous isotonic solutions,

Somazina 1gm Injection : 4ml Ampoule

Somazina 500 mg Tablet: Strip of 10 tablets

Somazina 1g Tablet: Strip of 10 tablets

You might also like