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    An Introduction To Grignard Reagents

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    Anonymous JOOQkGbwoR
    Grignard reagents are organic compounds made from halogenoalkanes and magnesium. They are produced by adding the halogenoalkane to magnesium in ether. This forms an alkyl- or aryl-magnesium halide compound. Common reactions using Grignard reagents include adding the reagent directly to other compounds. Proper safety precautions must be taken when working with ether due to its flammability and anesthetic properties.

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    An Introduction To Grignard Reagents

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    Anonymous JOOQkGbwoR
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    Grignard reagents are organic compounds made from halogenoalkanes and magnesium. They are produced by adding the halogenoalkane to magnesium in ether. This forms an alkyl- or aryl-magnesium halide compound. Common reactions using Grignard reagents include adding the reagent directly to other compounds. Proper safety precautions must be taken when working with ether due to its flammability and anesthetic properties.

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    Grignard reagents are organic compounds made from halogenoalkanes and magnesium. They are produced by adding the halogenoalkane to magnesium in ether. This forms an alkyl- or aryl-magnesium halide compound. Common reactions using Grignard reagents include adding the reagent directly to other compounds. Proper safety precautions must be taken when working with ether due to its flammability and anesthetic properties.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    12 views2 pages

    An Introduction To Grignard Reagents

    Uploaded by

    Anonymous JOOQkGbwoR
    Grignard reagents are organic compounds made from halogenoalkanes and magnesium. They are produced by adding the halogenoalkane to magnesium in ether. This forms an alkyl- or aryl-magnesium halide compound. Common reactions using Grignard reagents include adding the reagent directly to other compounds. Proper safety precautions must be taken when working with ether due to its flammability and anesthetic properties.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    AN INTRODUCTION TO

    GRIGNARD REAGENTS
    This page takes an introductory look at how Grignard
    reagents are made from halogenoalkanes
    (haloalkanes or alkyl halides), and introduces some of
    their reactions.

    Making Grignard reagents


    What are Grignard reagents?
    A Grignard reagent has a formula RMgX where X is a
    halogen, and R is an alkyl or aryl (based on a
    benzene ring) group. For the purposes of this page,
    we shall take R to be an alkyl group.
    A typical Grignard reagent might be CH3CH2MgBr.
    The preparation of a Grignard reagent
    Grignard reagents are made by adding the
    halogenoalkane to small bits of magnesium in a flask
    containing ethoxyethane (commonly called diethyl
    ether or just "ether"). The flask is fitted with a reflux
    condenser, and the mixture is warmed over a water
    bath for 20 - 30 minutes.

    Everything must be perfectly dry because Grignard


    reagents react with water (see below).

    Warning! Ethoxyethane (ether) is very dangerous to


    work with. It is a liquid with a boiling point of only
    34.5C, and is extremely flammable. It is also an
    anaesthetic. Under no circumstances should you try to
    carry out this reaction without properly qualified
    guidance.
    (I was challenged by a reader because I had
    previously used the word "inflammable" rather than
    "flammable" in this paragraph. In fact, confusingly, the
    two words mean exactly the same thing. However, by
    switching to "flammable", I have removed any possible
    confusion.)

    Any reactions using the Grignard reagent are carried


    out with the mixture produced from this reaction. You
    can't separate it out in any way.

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