How Dancing Really Stops the Clock

Acknowledgments

To my deceased and beloved parents Bob and Marcella, for their enduring grit and love.

To my grown adult children for their faith in me.

To my professional colleagues for tolerating my weaknesses.

To the deceased Professor Radulovacki, who taught me science research and to find joy in the discovery of small things.

To my wife Kate, for her enduring faith, hope and love.

Table of Contents

Acknowledgments

Appendix

Introduction

The Crux of End Organ Interstitial Space Signaling Control: Pro Versus Anti-Inflammatory Signaling Streams and Metabolic Rhythms

Chapters

Chapter One

The Signaling and Metabolic Vulnerability of the End Organ Cell’s Interstitial Space

Chapter Two

How the Capillary Cell’s Dance Steps Execute Precision Multipurpose

Chapter Three

How Chronic Inflammatory Interstitial Space Signaling Streams and Metabolic Rhythms Secede Anti-Inflammatory Signaling Control

Chapter Four

The Interstitial Space Signaling and Metabolic Repercussions of an Inconsistent Capillary-Endothelial Cell Dance Step Rhythm

Chaper Five

How and Why Capillary Cell’s Outer Membrane Complex Pseudocapillarize and Mitochondria Lose Functional Reserve

Chapter Six

The Ebb and Flow of Interstitial Space Vascular Inflammatory Free Radicals and How They Pulse Anti or Proinflammatory Rhythms to the Interstitial Space

Chapter Seven

The Mechanics of the Anti-Inflammatory Capillary Cell Dance Step: The "Pace and Stem" Effect

Chapter Eight

The "Ricochet and Backwash" Effects of the Dance Step Rhythm

Chapter Nine

When End Organ Interstitial Spaces Lose Their Signaling Way: The Path Towards Chronic Inflammatory Intent

Chapter Ten

The Sequential Maturing of a Chronic Inflammatory Interstitial Space Signaling Proforma: Morphing into the Inflammatory Matrix

Chapter Eleven

The Final Chronic Inflammatory Interstitial Space Solution: The Anti-Organ

Chapter Twelve

Scarring: One Outcome of Signal Turned Mesenchymal/Lymphocyte Cell Purposed Conversion from Darker Interstitial Space Signaling Rhythms

Chapter Thirteen

How Infectious Agents Tie into and Extend End Organ Interstitial Space Proinflammatory Signaling Rhythms

Chapter Fourteen

Hyper Coagulopathies and Thrombosis: How the Chronically Inflamed Endothelial Cell Interstitial Space "Double Whammy" Induces End Organ Hypoxia and Ischemia

Chapter Fifteen

The Lethal Integration of Cancer Cells into Chronic Inflammatory Signaling Streams and Metabolic Rhythms

Chapter Sixteen

How Immunoglobulins Lose their Anti-Inflammatory Edge to Become Interstitial Space Signal Maligned

Chapter Seventeen

The DNA Pothole

Chapter Eighteen

The Interstitial Space Big STING!

Chapter Nineteen

The Dubious Conversion of End Organ Interstitial Spaces to Proinflammatory Signaling Streams and Metabolic Rhythms: A Fait Accompli?

Chapter Twenty

Epilogue: Avoiding a Midlife Chronic Inflammatory Signaling and Metabolic Crisis

Appendix

Bibliography

Appendix

Figure One:

Interstitial Space (IS) Vascular Inflammatory Free Radicals (VIFRs) and the Capillary Cell’s (CC) Continuous Outer Membrane (COM) Permeability Pivot

Figure Two:

(IS) (VIFR) Induced (CC) (COM) Chain Reactions

Figure Three:

The (CC) (COM) Permeability Pivot will Facilitate the Combustion Swing of (CC) Mitochondria to Produce Either Nitric oxide (NO) or Energy (ATP) as the (CC) (COM) makes Multiple Dance Step Related Adjustments to Increase or Decrease its Permeability to Funneled (IS) Inflammatory Mediators (IA)

Figure Four:

The Mechanics of (CC) (COM) Funneled, Sequenced and Precision Purposed (IA) Choreography

Figure Five:

The (CC) Dance Step Rhythm is Dependent upon the Timely (IA) Execution of (VIFR) Removal

Figure Six:

How the (CC) Outer Membrane Complex (OMC) and (COM) in Particular Responds to the (IS) Mesenchymal (M) All Clear Inhibitory Signal

Figure Seven:

Pulsed Anti-Inflammatory Signaling Streams and Metabolic Rhythms Chain React a Back-and Forth Pivot and Swing of (CC) (OMC) Permeability and Mitochondrial Combustion that Redirects a Counterbalanced Dance Step Multipurpose

Figure Eight:

The Pulsed Anti-Inflammatory (CC) Mitochondrial (NOCC) and (ECC): A Rhythmic Signaling, Metabolic and Functional Back-and Forth Counterbalance, that Combines with The (CC) (OMC) Permeability Pivots, to Precision Execute Multipurpose

Figure Nine:

(CC) Counterbalanced Mitochondrial Combustion Signaling and Metabolic Rhythms, within the Context of the (CC) Dance Step, will Facilitate and Quality Assure (CC) Multipurpose Execution

Figure Ten:

Counterbalancing a Sequential (CC) Dance Step Rhythm Requires the Timely Execution of Each Sequential Dance Step Purpose

Figure Eleven:

The Linchpin of a Persistent Chronic Inflammatory (IS) Signaling and Metabolic Crescendo: Too Many (IS) (VIFRs) that Cannot be Timely (CC) Dance Step Removed

Figure Twelve:

The Loss of (CC) Dance Step Rhythm, Functional Counterbalance and Multipurpose Execution will Increase (CC) (IA) (IS) Funneling Mistakes from Combinations of (CC) (OMC) Pseudocapillarization, the Reduction of (CC) Mitochondrial Reserve and the Silencing of its Nuclear Chromosomal DNA Coding Capacity (as its Protective Telomeres Shorten)

Figure Thirteen:

The Misappropriated (IS) (IA) Funneling through the Compromised (CC) (OMC) will Outcome an (IS) Purpose Misalignment that will Further Deter (CC) Dance Step Rhythm and Enable the Expression of Chronic Inflammatory Intent

Figure Fourteen:

The Reverberation of Chronic Inflammatory (IS) (IA) Signaling and Metabolic Rhythms will Abort the (CC) (OMC) Dance Step Permeability Pivot which Marginalizes the (CC) Mitochondrial (NOCC) to Result in Loss of (CC) Signaling, Metabolic and Multipurpose Execution

Figure Fifteen:

Persistent (IS) Chronic Inflammatory Signaling Streams and Metabolic Rhythms will Dismantle the Anti-Inflammatory (CC) Dance Step Rhythm and its Execution of Multipurpose

Figure Sixteen:

(IS) Chronic Inflammatory Signaling and Metabolic Consolidation and the Pseudocapillarization Effect on the (CC) (OMC) Enables the Chronic Inflammatory (IS) Matrix to Pirate (IS) Intent

Figure Seventeen:

The Maturing of Chronic Inflammatory (IS) Signaling and Metabolic Purpose towards Anti-Organ Disease Venues (DVs)

Figure Eighteen:

The Full Expression of Anti-Organ (DVs): The Anti-Inflammatory (CC), (IS) and (M) Signaling and Metabolic Capitulation that Enables the Anti-Organ to Divert (IS) Functional Rhythms towards Its Own Purpose

Figure Nineteen:

Breaking the Thread of Chronic Inflammatory (IS) Signaling and Metabolic Chain Reactions: Finding (CC) Dance Step Traction from (IS) (VIFR) Reduction and Decreased (DV) Posturing

Figure Twenty:

Summarizing the Executed Recycling of (CC) Dance Step Rhythms: Integrating the Counterbalanced Anti-Inflammatory Execution of (CC), (IS), (M) and (EOC) Purposes within the Context of (CC) Dance Steps

Introduction

The Crux of End Organ Interstitial Space Signaling Control: Pro Versus Anti-Inflammatory Signaling Streams and Metabolic Rhythms

An Introduction to End Organ Interstitial Space Streaming Signal Momentum

The Signal and Metabolic Engineering of a Reverberating Capillary Cell Dance Step Rhythm

Cytokines, free radicals, electromagnetic wavelets, enzymes, hormones and other assorted proteins are often bundled into functional streams and rhythms within cells, interstitial spaces or blood plasma to cause pulsed chain reactions which provides momentum towards the execution of timely circadian purposes. Within the interstitial space of end organs, these signaling and metabolic streams are flanked by and controlled from either pro or anti-inflammatory influencers, the ladder of which originates from a finely tuned and pulsed capillary cell dance step rhythm. It is within the context of this rhythm that precision choreographed inflammatory mediators are pulsed and funneled into the interstitial space to remove inflammatory breach and secure its hygiene. The success of interstitial space inflammatory breach removal, which typically involves the molecular reduction of vascular inflammatory free radical impediments, will produce sufficient signaling and metabolic momentum to herald the onset of the next endothelial cell dance step which repletes a completely different type of recycled purpose. When executed the corresponding chain reactions the dance step elicits will complement and purpose fulfill the next pivot and swing step.

The back-and-forth rhythm of the capillary (and downstream endothelial) cell dance step rhythm becomes integral as to how the nearby abluminal interstitial space will functionally maneuver its own purpose fulfillment that includes the unique functional rhythms of its end organ cell. When pulse orchestrated in a counterbalanced dance step rhythm, each dance step will emanate circadian signaling streams and metabolic rhythms that drive a multipurpose anti-inflammatory execution whose fulfillment auto perpetuates the health, integrity and functional direction of the capillary cell, interstitial space and its corresponding molecular and transcellular constituents.

The manifest health of these rhythms is intimately linked to and coordinated with everyday behaviors that either favor or disavow the capillary cell dance step continuity. These aforementioned behaviors involve everyday lifestyle decision making which on the surface may appear innocuous towards influencing adverse health outcomes. These subtle but often repetitive behaviors could resonate resistance towards the integrity of the sleep wake cycle, the capacity to manage stress, the capability to regularly exercise, or the motivation to avoid dietary sugars, processed food or red meat. It could also lower the avoidance threshold towards avoiding other addictions such as tobacco products, alcohol, or drugs. The aggregate of these daily proinflammatory lifestyle choices will push reliable compilations of vascular inflammatory free radicals into the systemic circulation and end organ interstitial spaces that will in turn induce chain reactions that eventually nuance chronic inflammatory signaled and metabolic rhythms. Their effects will push signal and metabolic against the capillary cell dance steps and its counterbalanced rhythm to eventually interstitial space enable the maturing of chronic inflammatory outcomes.

This real time confluence between lifestyle choices, vascular inflammatory free radical interstitial space displays and the subsequent capacity of the capillary cell to dance step repulse them defines the anti-inflammatory integrity of the interstitial space in terms of how it manages its sanitation and resists chronic inflammatory overtures while enabling the nearby end organ cell to use the signaling and metabolic format to optimally function. In these potentially anti-inflammatory vulnerable interstitial space settings, the capillary cell dance steps can become unbalanced and desynchronized and subsequently lose their functional verve. As the dance step rhythm falls into functional disarray, its corresponding anti-inflammatory multipurpose fulfillment becomes less satisfying thereby inviting the interstitial space assemblance of chronic inflammatory rhythms as capillary cell funneled space immune arsenal become less anti-inflammatory compliant in executing purpose fulfillment.

The implication from a deteriorating capillary cell dance step rhythm is that its pulsed signaled and metabolic rhythms would be less anti-inflammatory reliable. Given a sufficient chronic inflammatory interstitial space nuance and the capillary cell’s dance step rhythm will mirror in the opposite direction as it can no longer reconcile anti-inflammatory multipurpose. When this occurs, the signaled and metabolic interstitial space processes virilize towards a chronic inflammatory conversion.

One early key factor to this foreboding interstitial space transition is how vascular inflammatory free radical interstitial space impingements become relentless to where they cannot be reliably reduced or eliminated. In this proinflammatory scenario, the capillary cell’s dance steps begin to flail as its rhythm is forced to spend more of its dance time suspended towards funneling inflammatory mediators into the interstitial space. This persistent dance step delay keeps the capillary cell out of rhythm, decreased its signaling and metabolic counterbalance and longer-term functional viability as chronic inflammatory interstitial space rhythms gather virility and intentionality.

One more key factor that increases chronic inflammatory interstitial space impropriety is how the interstitial space can transition incoming purpose neutral immune arsenal to be signal turned to endorse chronic inflammatory maneuvering. This can occur because the capillary cell’s outer membrane complex allows these immune funneling snafus due to its declining capacity to anti-inflammatory choreograph purpose precise immune arsenal into the interstitial space. This occurs as its outer membrane complex loses infrastructure capacity from diminished restitution due to a declining dance step driven nitric oxide combustion cycle. As purpose neutral interstitial space immune arsenal become signal converted from chronic inflammatory signaling rhythms, their purpose gets hijacked to conform towards and further virilize their intent. With persistent forbearance, they will posture a purpose that will enable interstitial space disease consorts.

This conversion of the interstitial space from anti to proinflammatory rhythms will occur over time with the rate of conversion dependent on vascular inflammatory free radical fuel, the degree to which purpose neutral immune arsenal have penetrated the interstitial space, the maturation of chronic inflammatory signaling rhythms, and the decay of the capillary cell itself and its corresponding dance steps. As darker interstitial space signaling and metabolic rhythms consolidate, they will purpose virilize by signal pirating the capillary cell’s outer membrane complex to further increase interstitial space funneling of specific immune arsenal that can be signal aligned to a chronic inflammatory revisionist realm. By dumbing down the disabled capillary cell’s outer membrane complex into their immune funneling agent, chronic inflammation re envisions the interstitial space towards its own purpose. The signaling and metabolic rhythms it musters become fodder for a variety of interstitial space chronic inflammatory entanglements that prioritize oxygen deficits, hyper coagulopathies, the birthing of infections, the advent of different types of scarring, the increasing displays of immune ignored cancer cells, and the proliferation of tweaked immunoglobulins whose electron exposures forebear autoimmune mishaps.

The scope of these chronic inflammatory bursts will not just involve one end organ’s interstitial space but will bisect multiple end organs simultaneously but not necessarily with the same mosaic of disease outcomes. The different end organ chronic inflammatory outcomes will become codependent on how chronic inflammatory signaling and metabolic rhythms opine the interstitial space to subsequently encrypt the nature of the disease outcome or mosaic. In these instances, and in the context of a systemically diffuse capillary and endothelial cell functional decline, upstream oxygen depravity and proclivity towards hypercoagulable states and insulin resistance will forbear how an end organ disease mosaic unfolds in different end organs. In these systemic end organ chronic inflammatory interstitial space outcomes, the signaling and metabolic milieu they portend will deploy disease consorts based on what the end organ cell is most vulnerable to.

The Importance of the Capillary Cell’s Dance Step Rhythm Counterbalance

The capacity of the capillary cell to extoll sufficient anti-inflammatory multipurpose execution to the interstitial space will depend on how resilient its counterbalanced dance step rhythm has been maintained. Counterbalance becomes dependent primarily on how well the dance steps can timely reduce vascular inflammatory interstitial space free radical impingements. When effective, the next dance step pivot and swing purposed execution can fully manifest without being delayed or aborted. The capacity to timely eliminate vascular inflammatory free radical impediments will require that the capillary cell embodies the fullness of its dance step rhythm as its pace, ricochet and backwash align its anti-inflammatory purpose with the blood plasma constituents and interstitial space allies. The timeliness of free radical interstitial space elimination will parlay a signaling and metabolic interstitial space nuance that is intimately linked to the capillary cell’s dance steps and its pulsed anti-inflammatory reverberations. Without a timely vascular inflammatory free radical interstitial space removal, the capacity of the dance step rhythm to perform will decline as next dance step signaling and metabolic counterbalance is lost. Without counterbalance, dance step infrastructure restitution will get short changed wo here signaling and metabolic rhythms cannot be compensated for. The result will nuance a continued dance step purposed decline whereby funneled immune arsenal into the interstitial space will no longer exclusively cater to anti-inflammatory execution. The funneled immune discrepancies become a chronic inflammatory stepping stone for signal conversion towards a proinflammatory purpose.

When the capillary cell’s dance steps no longer pulse anti-inflammatory counterbalance, the rhythm will lose a functional forbearance whereby its outcomes lack multipurpose quality assurance. This proinflammatory bias does not occur from isolated dance step deficiencies but rather is a collective of inappropriate funneled immune contingents that become signal purpose realigned as a result of the lack of thorough capillary cell outer membrane complex and infrastructure restitution. Because of this, the capillary cell’s outer membrane complex loses functional infrastructure (adhesion receptors, pores, switches, voltage gradients) whereby it can no longer accurately choreograph interstitial space funneled immune contingents that will execute a precise anti-inflammatory purpose of inflammatory breach removal. The loss of this capacity can be blamed on a persistently diminished dance step nitric oxide combustion cycle. As the capillary cell’s outer membrane complex pseudocapillarizes its anti-inflammatory purpose execution diminishes which becomes a proinflammatory linchpin to interstitial space outcomes.

This theme of interstitial space immune arsenal becoming signal converted to a chronic inflammatory purpose will eventually convey its own virulence and intentionality. This will enable an interstitial space purpose transition whereby distinct chronic inflammatory signaling and metabolic rhythms will framework a lattice that will elicit disease seeding. The loss of the capillary cell’s dance step counterbalance and a quality assured anti-inflammatory multipurpose fulfillment becomes the necessary infrastructure adjustment that is required for disease consorts to become agents to the interstitial space. This chronic inflammatory interstitial space transitioning will shift the capillary cell’s dance step rhythm and outer membrane complex from a potent anti-inflammatory facilitator to a signal hacked purveyor of chronic inflammatory interstitial space intent.

The capillary-endothelial cell, with its unique blend of purpose sophisticated outer membrane complex receptors and mitochondria that will urgently respond to outer membrane complex energy requirements, that when combined with a cellular infrastructure that functions without oxygen combustion, becomes the primary facilitating entity for pacing and distributing interstitial space anti-inflammatory outcomes. With an elegant and functionally distinct set of outer membranes and sub membranes, the capillary cell’s luminal and abluminal surfaces parlay sophisticated arrays of interstitial space and blood plasma signaling and metabolic crescendos that permutate endo and exocytic anti-inflammatory rhythms that purpose execute its dance steps. When this occurs as a counterbalanced circadian rhythm, the pulsed dance steps execute multipurposed rhythm while at the same time providing for a signaled and metabolic framework for the next dance step’s purpose fulfillment. When this occurs, the dance step rhythm becomes an anti-inflammatory powerhouse that is methodical, recurring, signal and metabolically counterbalanced, and functionally quality assured.

The elicited dance step rhythms will stream cytokines, enzymes, electromagnetic wavelets and even their own blend of anti-inflammatory free radicals that will purpose fulfill while laying the signaling framework for the next dance step. When this occurs, the permutated dance step purpose fulfillment will attribute signaling rhythms that will chain react the onset of the next dance step. The pulsed fulfillment of these dance step anti-inflammatory rhythms become harbingers of interstitial space health and end organ cell functional resolve as they also contribute towards the prevention of chronic inflammatory disease consorts. The dance step counterbalance and multipurposed execution is supported by a cadre of paced metabolic interstitial space shifts that involve pH, osmolality and osmotic pressure gradients, oxygen and carbon dioxide tensions and pyruvate/ fatty acid distribution ratios. These dance step pulsed metabolic rhythms become additive towards the anti-inflammatory purposed execution of all end organ interstitial spaces and their corresponding allied cells as they conform their rhythms and purpose to the capillary cell dance steps and the metabolic fluxes they convey.

The Importance of the Timely Interstitial Space "All Clear" Signal

When vascular inflammatory free radical interstitial space elimination becomes "a fait accompli", the compilation of metabolic and signaled rhythms will reverberate an "all-clear" signal whose chief architect becomes a mesenchymal cell subset. The signaling crescendo will induce the capillary cell’s basement membrane to shift its outer membrane complexes’ permeability away from further interstitial space immune funneling. The all-clear signal will find additional traction within the interstitial space’s landscape from a host of pulsed metabolic indicators that will occur within the all-clear signaling entourage. Once the capillary cell’s basement membrane receives this inhibitory signal, restricted interstitial space immune funneling will occur from signaled chain reactions elicited from the capillary and downstream endothelial cell’s continuous outer membrane that is permutated by fluxing cAMP levels. As transmembrane cAMP levels increase, activated switch operatives among other things will restrict luminal access of continuous outer membrane adhesion receptors to its glycocalyx and circulating white blood cells or platelets. This will also coincide with across-the-board reductions of immune arsenal endocytosis through its gap junction orifice, channel, endocytic vesicles and transcellular transport channels as voltage gradients increase and the cell’s outer membrane configuration flattens out.

As this occurs, the capillary cell’s continuous outer membrane will no longer need extra energy or calcium ions to assist in the transmembrane interstitial space immune funneling efforts. They will in turn form concentration gradients within the capillary cell’s cytoplasm and predictably follow these gradients into the nearby mitochondrial inner membrane space. It is here that they become a feedback loop signaling force with the mitochondrial inner membrane as they signal loop inhibit the electron transfer through the cytochromes that will deactivate ATP synthase while simultaneously activating matrix nitric oxide synthase and nitric oxide combustion. The coming and going of mitochondrial calcium, energy and magnesium to and from the capillary cell’s continuous outer membrane and mitochondria become important dance step feedback loops that become integral to its pulsed rhythms and multipurpose anti-inflammatory execution.

As the all clear signaling manifesto chain reacts resistance towards additional interstitial space immune funneling, the downward shift in the capillary-endothelial cell’s outer membrane complex permeability gradient and its mitochondrial combustion to nitric oxide becomes part of the cell’s counterbalancing master plan of functional anti-inflammatory homeostasis. When the dance step rhythm finds an optimal signaling and metabolic counterbalance, its anti-inflammatory functional outcomes will be quality assured and timely executed. The dance step rhythm’s resilience becomes an abiding anti-inflammatory reverberation of dance step multipurposed execution as each completed pivot and swing dance step gets paced and backwashed into the interstitial space and systemic circulation.

The dance step’s multipurposed execution can be constrained in the short term as the rhythm may struggle to remove vascular inflammatory free radical interstitial space impingements. This rhythm imbalance can be signal and metabolically compensated for by capillary cell infrastructure adjustments. Over time however, a persistent overcompensation of dance steps to purpose execute will cause the rhythms to become unbalanced and lose functional resolve.

Why the Capillary Cell’s Mitochondrial Combustion Cycles are Critical to Dance Step Purpose Fulfillment

The capillary and downstream endothelial cell’s dance step derived pullback of inflammatory mediators from the interstitial space will mean that mitochondrial combustion energy surges will be no longer required to facilitate their interstitial space active transport from blood or lymph plasma. As continuous outer membrane cAMP, transitions permeability calcium and magnesium ions and ATP to and from mitochondria facilitate its execution. In aggregate they form concentration gradients based on outer membrane complex permeability requirements that feedback loop permeability execution on the one hand and mitochondrial combustion preference, be it energy or nitric oxide on the other. These outer membrane complex and mitochondrial raw materials will easily penetrate the porous mitochondrial outer membrane to interact with the more voltage potent inner membrane to signal shifts in combustion output based on their intermembrane space concentration gradients. In this fashion, calcium, magnesium and ATP become the equivalent of facile inner membrane on-off switches that facilitate the rotation mitochondrial combustion back and forth between energy and nitric oxide gas. Depending on combustion output, there will occur a paradigm shift in the capillary cell ‘s purpose fulfillment as either energy or nitric oxide gas production facilitate entirely different functional signaling and metabolic rhythms. Their outcomes produce a mitochondrial and transcellular functional divergence but each requires the other to counterbalance and maximize their combustion benefits.

When the dance step’s outer membrane complex permeability shifts to inhibit interstitial space immune funneling it will feedback loops to mitochondrial signaling rhythms that will inhibit further energy combustion while stimulating a spurt of nitric oxide production which then causes an entirely different set of signaling, metabolic and purpose derived fulfillments. Interestingly, the nitric oxide derived fulfillment is required to maximize the next dance step’s energy combustion purpose fulfillment and so on. These signaling, metabolic and functional transactions that occur with each permeability pivot and combustion swing dance step will not only permutate fulfillment through the capillary cell, but will also signal and metabolically facilitate its functional rhythm into the interstitial space. In this manner the dance step’s purpose fulfillment becomes an interstitial space (and blood plasm) footprint that EXECUTES AN ANTI-INFLAMMATORY interstitial space purpose that conforms to the intent of the capillary cell dance step rhythm. When the pivot and swing capillary cell’s dance step rhythm is timely and purpose fulfilled it forms an aligned signal and metabolic counterbalance that algorithms a quality assured purpose that is transmitted to the interstitial space, its cellular allies that reside there as well as to the blood plasma as the rhythm longer term success requires that it prepares its interstitial space domain and blood plasma for the next step’s purposed execution.

The timely and purpose precise dance steps will to and from the interstitial space and blood plasma will chain react rhythms of activated anti-inflammatory cytokines, enzymes, proteins, hormones, free radicals and electromagnetic wavelets that will produce a collective execution of anti-inflammatory multipurpose. Their reverberation becomes the backdrop towards a counterbalanced and functionally-quality assured multipurposed outcome that is to the mutual benefit of the capillary cell itself, its interstitial space domain, the mesenchymal and end organ cells that reside there as well as with distant endothelia and end organ cells.

The anti-inflammatory capillary and endothelial cell dance step rhythm will at the same time subvert the interstitial space towards a chronic inflammatory signaling and metabolic manipulation. The reverberation of the anti-inflammatory dance step rhythm will contrive a signaling and metabolic wall that will buttress the interstitial space and blood plasma from chronic inflammatory overtures. The back-and-forth pulsed dance step rhythm will integrate itself with its interstitial space partners to precision purpose outcomes that are beneficial to all cellular parties. The derived anti-inflammatory rhythms will inherently suppress chronic inflammatory seeds thereby preventing their escalation towards disease consorts.

The Importance of Dance Step Derived Anti-inflammatory Outcomes

Anti-inflammatory end organ interstitial space signaling and metabolic rhythms become jeopardized when chronic interstitial space inflammation jams the timing of the capillary cell’s dance step rhythm. This can be as simple as not timely removing vascular inflammatory free radical interstitial space impingements or can be more sinister as immune funneling errors into the interstitial space become increasingly de rigueur. Their resilience will cause the capillary cell to minimize its infrastructure reconstitution thereby placing its functional reserve in a tailspin. Chief among its organelle outliers will be its increasingly destitute outer membrane complex, as its lack of restitution increases pseudocapillarization, meaning it no longer has the functional capability to precision choreograph tangible immune remnants into the interstitial space to eliminate all forms of inflammatory breach. This loss of anti-inflammatory outer membrane complex transparency will delay and minimize the next dance steps critically important rhythm, the nitric oxide combustion cycle it permeates, and all of the signaling and metabolic fallout that occurs from its less than stellar purposed execution.

As anti-inflammatory purpose inept immune contingencies are persistently pushed into the interstitial space, the dance step rhythm will continue to break down from chronic inflammatory chain reactions. The process creates an increasingly anti-inflammatory divergent interstitial space rhythm that keeps vascular inflammatory interstitial space free radicals in play and creates an interstitial space signaling and metabolic milieu that increasingly virilizes chronic inflammatory intent to where the disabled capillary cell outer membrane complex becomes a signaling attribute towards chronic inflammatory interstitial space outcomes. The persistent block in the capillary cell’s dance step rhythm will uncouple its anti-inflammatory benefits which become the linchpin to interstitial space decline and capillary cell functional senescence.

The Vascular Inflammatory Free Radical "Pester and Fester Effect" and Subsequent Chronic Inflammatory Interstitial Space Contingencies

Given sufficient diversity, volume and persistence, vascular inflammatory free radical interstitial space impingements can increasingly marginalize the capillary cell’s dance step circadian rhythm by not getting timely removed thereby preventing or delaying the next dance step. Their "pester and fester effect" will require the capillary cell’s outer membrane complex to keep immune funneling into the interstitial space even if they are not capable of eliminating the free radical. This immune ineptness becomes a boon to chronic inflammatory interstitial space rhythms as these bungling immune remnants will signal convert to enhance proinflammatory rhythms thereby increasing capillary cell dance step ineffectiveness. The inability of the capillary cell to subdue the increasing displays of chronic inflammatory rhythms will eventually lead to the conversion of the interstitial space from an anti to proinflammatory signaling rhythm. It is in this context where the capillary cell’s outer membrane complex loses its capacity to choreograph funneled immune arsenal into the interstitial space that will execute an anti-inflammatory purpose. Over time and as the capillary cell’s outer membrane complex pseudocapillarizes and interstitial space chronic inflammatory signaling and metabolic rhythms virilize, the purpose of the capillary cell’s declining infrastructure will convert to a chronic inflammatory cause. The maturing of chronic inflammatory interstitial space intent is executed by its matrix and anti-organ.

The chronic inflammatory-matrix will begin to scale a proinflammatory interstitial space transition by signal pirating the capillary cell’s basement membrane and subsequent outer membrane complex. Doing so will elicit a different type of immune funneling into the interstitial space that will cater to a chronic inflammatory expression rather than to interstitial space hygiene. This purpose transitioning within the interstitial space virilizes chronic inflammatory intentionality as its blended rhythms become a signaling and metabolic edifice for disease seeds. As chronic inflammatory signaling and metabolic rhythms rewire the interstitial space their nomenclature to a different purpose identity, the scope and power of anti-inflammatory rhythm identity diminishes.

The outcome to this interstitial space transitioning is a considerably anti-inflammatory purpose weakened capillary cell that is no longer capable of choreographing or pacing anti-inflammatory rhythms that keep the interstitial space sanitized and the end organ cell functionally optimal. As the chronic inflammatory interstitial space anti-organ builds out it signaling and metabolic hierarchy, disease venues will seed the interstitial space. When this occurs, the capillary and true end organ cell will become senescent as their outer membranes divorce functional intimacy with each other. The chronic inflammatory interstitial space transitioning will require a metabolic rhythm follow through as non-pulsed but increasing insulin resistance, reduced oxygen tensions, acid-base abnormalities and hypo osmolality gradients mature.

With a chronic inflammatory interstitial space transformation, anti-organ disease consortiums take root by signal dialing into these rhythms. In this manner infectious agents, cancer cells, scar tissue, hypercoagulable states, and autoimmune complexes find integrative virulence as they take advantage of chronic inflammatory signaling platitudes, favorable metabolic conditions, and an increasingly complacent anti-inflammatory interstitial space functional hierarchy. The struggle for control of this end organ interstitial space domain is high stakes but can very easily slip into a chronic inflammatory takeover as its signaling and metabolic rhythms competitively silence those that are occurring from an increasingly diminished anti-inflammatory immune hierarchy. The rate and degree of anti-inflammatory surrender is defined by multiple factors that include the volume and diversity of vascular inflammatory free radical interstitial space exposures, the degree to which the capillary cell’s outer membrane complex has pseudocapillarized, the volume and type of funneled interstitial space immune arsenal that have been signal converted and the inherent functional priorities of the end organ cell and how they predispose to being marginalized by certain chronic inflammatory disease venues.

The Importance of the Capillary Cell’s Dance Step Cadence

When capillary cells pulse and optimal pivot and swing dance step rhythm, they will signal and metabolically reinforce anti-inflammatory interstitial space outcomes that become the basis for the dance step’s ricochet, pace, stem and backwash to and from the interstitial space, its allied cellular cohabitants and the blood/lymph plasma. The pulsed and fluxing anti-inflammatory rhythms of the capillary cell’s outer membrane complex permeability pivots and mitochondrial combustion swings produce a reverberating signal and metabolic precipice that communicates dance step multipurpose as it communicates, supplies sustenance and procures next step functional countenance to and from the interstitial space and blood/lymph plasma. In the case of its interstitial space mesenchymal and end organ cells, the capillary cell dance steps will signal and metabolically align anti-inflammatory rhythms that lock and key dance step purpose fulfillment to these cells which integrate their functional rhythms to dance step purpose. That is, the capillary cell’s dance steps will rhythm an anti-inflammatory interstitial space fulfillment that will also enhance the functionality of its interstitial space mesenchymal and end organ cell neighbors.

In the case of the end organ cell, the capillary cell’s pulsed outer membrane complex permeability and mitochondrial combustion rhythms will purpose outcomes that are functionally opposite to those of its nearby end organ cell partner. That is when capillary cell outer membrane complex permeability increases to inflammatory mediator interstitial space penetration, the end organ cell’s outer membrane will increase resistance to the inflammatory assaults coming from the interstitial space thereby forming a barrier between them and its infrastructure. In likewise fashion, as the capillary cell revs up mitochondrial energy combustion to support active transport of immune contingents into the interstitial space, the end organ cell’s mitochondria are being signaled to do the opposite; that is to shut down their energy combustion (and functional rhythms) to instead focus on sustaining its nitric oxide production.

As the interstitial space’ becomes dance step sanitized, all clear signals will emanate from mesenchymal cells to the capillary cell’s basement membrane that will pivot and swing the next dance step. In this manner, the capillary cell’s dance step rhythm delivers a sequential and purpose defining string of anti-inflammatory signaling and metabolic rhythms that execute a multipurpose fulfillment to and from the blood plasma, interstitial space and its cellular allies. The pulsed reverberation of purpose specific anti-inflammatory cytokines, enzymes, hormones, proteins, free radicals and electromagnetic wavelets, and the corresponding metabolic rhythms they cause and effect, become signaled manifestations of timely dance step purpose fulfillment. Each dance step’s purpose fulfillment will threshold the success of the next dance step’s purpose which gets signal and metabolic messaged to and from the interstitial space and blood plasma.

Another important key to capillary cell dance step fulfillment is its backwash effect into the blood and lymph plasma. The pulsed rhythms it generates from the interstitial space, through the capillary cell and into the blood and lymph plasma will serve as a signaling and metabolic backdrop that will immune enhance to increase their future proficiency towards anti-inflammatory interstitial space immune funneling efforts. With each consecutive dance step rhythm multipurpose fulfillment, the prevailing signaling and metabolic momentum to and from the interstitial space will reverberate through the capillary cell a backwash into the plasma/lymph circulation that both immune refurbishes while establishing a backdrop towards a successful capillary cell anti-inflammatory choreographed interstitial space immune funneling effort. In this context, the dance step rhythm will seamlessly interconnect its anti-inflammatory multipurpose fulfillment with the end organ cell, interstitial space and blood/lymph plasma.

The Direct Relationship Between the Power of the Capillary and Downstream Endothelial Cell’s Dance Step Rhythm and a Systemic Multi-End Organ Anti-Inflammatory Trajectory

How Dancing Really Stops the Clock provides a clear descriptive of how the capillary cell’s dance steps defend the functional integrity of its interstitial space domain and its end organ cellular partners. The pulsed capillary and downstream endothelial cell dance step rhythms will signal and metabolically lead a mosaic of interlocking anti-inflammatory chain reactions from different immune cells and their activated cytokine rhythms that support interstitial space hygiene, transcellular restitution and end organ cell functional resolve as it conveys these outcomes to the blood/lymph plasma for future dance step success. In this conveyance, its backwashed anti-inflammatory rhythms will outcome next step purpose fulfillment as they intercept with circulating white blood cells, immunoglobulins, clotting factors, platelets and inflammatory proteins to tweak their molecular identity prior to being next dance step capillary cell choreographed and interstitial space identified. As this is occurring, anything that is chronic inflammatory circulating will become victims to the systemic anti-inflammatory backwash. This would include infectious agents, cancer cells, rogue immunoglobulins, or activated clotting factor contingents.

Thus, the capillary-endothelial cell’s dance step rhythm will not only signal loop anti-inflammatory crosstalk and purpose clarity to its interstitial space domain but will also extend this fulfillment towards a backwash that will systemically provide for further anti-inflammatory immune enhancement as backwashed cytokines, enzymes and assorted free radicals enter the blood and lymph plasma to molecularly tweak the configurations of circulating immune contingents in preparation for future interstitial space deployment. "How Dancing Really Stops the Clock" clarifies how the endothelial cell dance step rhythm renders anti-inflammatory salvos to and from the interstitial space that both connects and clarifies multipurpose management. This trans endothelial cell pluripotent immune holism will nurture a continuous flow of optimizing multi-end organ interstitial space hygiene and cellular refurbishment which in turn will allow for the expression of exceptional multi-end organ functional rhythms. The maintenance of this "anti-inflammatory tone" from the trans-capillary-and downstream endothelial cell’s dance step processes will require:

The timely (circadian) removal of vascular inflammatory free radical interstitial space impediments.

A recurring signal and metabolic counterbalanced and functionally quality assured capillary and downstream endothelial cell dance step rhythm that will cater multipurpose fulfillment.

A funneled interstitial