Yol. 15, 1977
Pharmacology
International Journal of
Experimental and Clinical Pharmacology
Editors:
B.B. Brodie, Bethesda, Md.
R. Domenjoz, Bonn
E S. Vesetl, Hershey, Pa.
Editorial Staff:
H. Breuer, Bonn
G.E. Gessa, Cagliari
B. Holmstedt, Stockholm
O. Hornykiewicz, Vienna
K. Karzel, Bonn
O. Kraupp, Vienna
P. l.echat, Paris
K. Lederis, Calgary, Alta.
E.G. McQueen, Dunedin
K. Mörsdorf, Bonn
F. Sjöqvist, Stockholm
G. Zbinden, Zurich
G. Zetler, Lübeck
P.A. van Zwieten,
Amsterdam
S. Karger • Basel • München • Paris • London • New York • Sydney
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Copyright 1977 by S. Karger AG, 4011 Basel (Switzerland), Arnold-Bocklin-Strasse 25
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Contents Vol. 15, 1977
No. 1
Aceto, M.D.: Flora, R.E., and Harris, L.S.: The Effects of Naloxone and Nalorphine
during the Development of Morphine Dependence in Rhesus Monkeys ..............
Zimmerman, S.; Zimmerman, A.M.; Cameron, I.L., and Laurence, H.L.: A'-Tetrahydrocannabinol, Cannabidiol and Cannaliinol effects on the Immune Response
of Mice ........................................................................................................................
Chaudhari, A.; Parmar, 5.5.; Singh, S.P.; Kumar, 5., and Spiro, H R.: Correlation
between Antiinflammatory and Antiproteolytic Properties of Substituted Benzy lid e n e s.....................................................................................................................
Anderson, G.F. and Fredericks, Ch.M.: Characterization of the Oxybutynin Antago
nism of Drug-Induced Spasms in Detrusor ...............................................................
Radd, J.P.: Marosi, J., and Fischer, J.: Comparison of the Antidiuretic Effects of Single
Intravenous and Intranasal Doses of DDAVP in Diabetes insipidus .......................
Babb ini, M.; Gaiardi, M., and Bartoletti, M.: Anorexic and Behavioural Effects of a
New Imidazo-Isoindole Derivative (Mazindol) in Comparison with ¿-Amphet
amine in the Rat .......................................................................................................
Nevasaari, K.; Alakare, B., and Kdrki, N.T.: Effect of Atropine on Bile Flow and
Biliary Excretion of 3H-Ouabain in the Isolated Perfused Rat Liver ....................
Hine, B.; Torrelio, M., and Gershon, 5.; Analgesic, Heart Rate, and Temperature
Effects of A“-THC during Acute and Chronic Administration to Conscious Rats. .
Kowalewski, K. and Kokodej, A.: Effect of Secretin on Myoelectrical and Mechanical
Activity of the Isolated Canine Stomach Perfused ex vivo .....................................
Adamson, R.H.; Zaharevitz, D.W., and Johns, D.G.: Enhancement of the Biological
Activity of Adenosine Analogs by the Adenosine Deaminase Inhibitor 2’-Deoxycoformycin ................................................................................................................
1
10
24
31
40
46
57
65
73
84
No. 2
Kishore, V.; Parmar, 5.5.; Kumar, 5., and Barthwal, J.P.: Anti-Inflammatory and Anti
proteolytic Properties of Substituted Guanidines .................................................... 97
Contents
IV
Kun, I.; Feszt, G.; Cuparencu, B., and Orban,
The Different Influence of Pre
dominantly Antiadrenergic and Antidopaminergic Neuroleptics on the Estrous
Cycle in Rats ............................................................................................................ 104
Parmar, S.S.; Chaudhary, M.; Chaudhary, S.K., and Spiro. H R.: Anticonvulsant Ac
tivity and Selective Inhibition of NAD-Dependent Oxidations by 1,4-Disubstituted Piperazines ......................................................................................................... 112
Ercan, Z.S. and Tiirker, R.K.: Histamine Receptors in the Isolated Rat Stomach
Fundus and Rabbit Aortic Strips ................................................................................118
Back. G. and Seidel, G.: Harmine Action in Rats with Lymphostatic Encephalopathy . 127
Riiegg, M. and Jaques, R.: Histamine-Releasing Effect of a Corticotrophin Derivative.
I. Histamine-Releasing Effect of a Nonadecapeptide in Comparison with that of
Other Histamine Liberators ........................................................................................ 134
Bodzenta, A. and Wisniewski. K.: The Effect of Prostaglandin E, on Central Cholin
ergic Mechanisms ..........................................................................................................143
Broughton. A.C.; Secord, D.C., and Scott, G. W.: Effects of Adrenergic Stimulation on
the Choledochoduodenal Sphincter M echanism ......................................................... 152
Fregly, M.J. and Rubin, M.L.: Effect of Some Substituted Pyrimidines on Develop
ment of Desoxycorticosterone-lnduced Hypertension in R a t s .................................. 162
Haustein, K. O.: Extraordinary Cardiac Effects of 16-Epi-Gitoxin in Comparison to
Ouabain in Cats and Dogs ........................................................................................... 178
No. 3
Dratman, M B.; Crutchfield, F.L.; Axelrod, J.; Utiger, R.D., and Marsh,
Tri
iodothyronine in Rat Submaxillary Salivary Gland: Effect of Altered Adrenergic
Function ........................................................................................................................193
Sandor, V. and Cuparencu, B.: Analysis of the Mechanism of the Protective Activity of
Some Sympathomimetic Amines in Experimental Ulcers ........................................208
Cuparencu, B. and Sandor, V.: Influence of Some Sympathomimetic Amines on the
Experimental Gastric Ulcers in Rats ..........................................................................218
Turrin, M.A. and De Moraes, S.: Effects of Sammarium on the Contractile Response of
the Isolated Guinea Pig Ileum to Acetylcholine, Histamine, Potassium and Barium 227
Page, J.G. and West, l..E.: Hypothermia in Rats Produced by Nabilone, a Synthetic
Cannabinoid ..................................................................................................................233
Yu, J.H. and Smith, C.B.: Effect of Cocaine and Desmethylimipramine on the Uptake,
Retention and Metabolism of 5H-5-Hydroxytryptamine in Rat Brain Slices . . . . 242
Severs, W.B.: Kapsha, J.M.: Klase, P.A., and Keil, L.C.: Drinking Behavior in Water
Deprived Rats after Angiotensin Receptor Blockade ................................................ 254
Sirek, A.; Sirek, O.V.; Policova, Z., and Kerekes, A.: Effect of Ergot Alkaloids on
Sulfonylurea-Stimulated Insulin Secretion in Dogs ...................................................259
Miller, I..; Cornett, T.: Drew, W.; McFarland, D.; Brightwell, D., and Wikler, A.:
Marijuana: Dose-Response Effects on Pulse Rate, Subjective Estimates of
Potency, Pleasantness, and Recognition Memory ......................................................268
Zagon, I.S. and McLaughlin. P.J.: Morphine and Brain Growth Retardation in the Rat . 276
Short Communication
Datta, R.K.: Antopol, W. f. and Ghosh, J.J.: Binding of Mescaline with Subcellular
Fractions upon Incubation of Brain Cortex Slices with | '"C'l Mescaline .............. 283
Contents
V
No. 4
Wade, A.E. and Evans, J.S.: Influence of Norethindrone on Drug-Metabolizing En
zymes of Female Rat Liver in Various B-Vitamin Deficiency States .................... 289
Zagon, I.S. and McLaughlin, P.J.: Effects of Chronic Morphine Administration on
Pregnant Rats and Their Offspring .......................................................................... 302
Belpaire, F.; Bogaert, M.; De Broe, M., and Mussche, M.; Serum Binding of Quinidine
in Experimental Acute Renal F a ilu r e ....................................................................... 311
Parry, G.J.G.: Concentration of Clonazepam in Serum and Cerebrospinal Fluid of the
S h e e p ............................................................................................................................. 318
Kowalewski, K. and Kolodej, A.: Effect of Intra-Arterial Infusion of Glucose on Secre
tory Activity of Isolated Canine Stomach . ............................................................ 324
Zwieten, P.A., van: Inhibition of the Central hypotensive Effect of Clonidine by
Trazodone, a Novel Antidepressant ............................................................................. 331
Smith, D.F.; Shimizu, M., and Schou, M.: Lithium Absorption, Distribution and
Clearance and Body Temperature in Rats Given Lithium plus Haloperidol . . . . 337
Pham-Huu-Chanh: Pham-Huu-Chanh, A.; Clavel, P.. and Lehmann-Schad, W.: Cardio
vascular Effects of Synthetic Substance P ...............................................................341
Kowalewski, K.: Pachkowski, T., and Secord, D.C.: Gastric Mucinous Secretion under
Various Conditions of Stimulation in Hypothyroid Dogs ........................................ 348
Plowman, J.; I.akings, D.B.: Owens, E.S., and Adamson, R.H.: Initial Studies on the
Penetration of Spirohydantoin Mustard into the Cerebrospinal Fluid of Dogs . . . 359
No. 5
Van Dyke, K.: Robinson, R.: Urquilla, P.: Smith, D.; Taylor, M.: Trush, M., and Wilson,
M.: An Analysis of Nucleotides and Catecholamines in Bovine Medullary Granules
by Anion Exchange High Pressure Liquid Chromatography and Fluorescence.
Evidence that Most of the Catecholamines in Chromaffin Granules Are Stored
without Associated ATP .............. . '..........................................................................377
Renis, M.; Giovine, A., and Bertolino, A.: MAO Activity in Rat Brain Stem and
Cerebral Cortex following Acute and Chronic Treatment with /.-Dopa and
Ethanol + L -D o p a ....................................................................................................... 392
Messiha, F.S.; Larson, J.W., and Geller, L: Voluntary Ethanol Drinking by the Rat:
Effects of 2-Aminoethylisothiouronium Salt, a Modifier of NAD:NADH and
Noreleagnine, a (3-Carboline Derivative ......................................................................400
Moratinos, J.; Ellis, S., and Potter, D.E.: Catecholamine-Induced Changes in Plasma
Glucose and Insulin Levels in the Unanesthetized Rabbit ..................................... 407
Warwick, R.O.; Bousquet, F., and Schnell, R.C.: Effect of Acute and Chronic
Morphine Treatment on Serotonin Uptake into Rat Hypothalamic Synaptosomes. 415
Severs, W.B. and Summy-Long, J. Y.: Norepinephrine-Induced Reflex Bradycardia after
Central Administration of Angiotensin II ..................................................................428
Viana, A.P.: Role of Adrenergic Mechanisms in Cardiac and Respiratory Effects of
Dioxin .......................................................................................................................... 436
Jaques, R.: The Pharmacological Activity of Tribenoside ................................................. 445
De Moraes, S. and Capaz, F.R.: An Analysis of the Effects of Cocaine on the Respon
siveness of the Isolated Guinea Pig Vas deferens to Noradrenaline and Other
Agonists ........................................................................................................................461
Contents
VI
Nousiainen, O.T.; Arnala, I.; Airaksinen, M.M., and Kokkola, K.: Potentiation of
0-Sympathomimetics with a-Adrenoceptor Blocking Drugs in Guinea Pig Trachea
and Human Bronchus Preparations .......................................................................... 469
No. 6
Sirek, A.M. T.: Sirek, A., and Sirek, O. V.: Failure of Ergotamine to Alter the Lypolytic
Effect of Somatotropin in D o g s ................................................................................
Fregnan, G.B. and Vidali, M.: Pharmacological Profile of a New Psychotherapeutic
Agent: 4-p-Fluorophenyl-5-N(N’-o-methoxyphenyl)piperazinoethyl-4-oxazolin-2one (LR 511) .............................................................................................................
Feldman, S. and Putcha, l.: Effect of Anti-Parkinsonism Drugs on Gastric Emptying
and Intestinal Transit in the Rat ................................................ ...........................
Grechishkin, L.L.; Gavrovskaya, L.K., and Goldfarb, V.L.: Effect of Derivatives of
3-(0-Aminoethyl)-l ,2,4-Triazole on the Histamine H,-and H,-Receptors ............
Green, R.L.: Paradoxical Effects of Calcium-Glucagon Interaction on Cardiac Muscle
Contractility of Isolated Guinea Pig Atria ....................................... ......................
Frey, H.-H.: Study into the Mechanism of Acetylsalicylic Acid-Induced Bronchoconstriction .....................................................................................................................
Mason, R. W.: The Binding of Aurothiomalate to Plasma Proteins in vitro ....................
Nang, L.S.; Cosnier, D.; Terrie, G., and Moleyre.J.: Consequence of Solubility Altera
tion by Salt Effect on Dissolution Enhancement and Biological Response of a
Solid Dispersion of an Experimental Antianginal D r u g ...........................................
Spierings, E.L.H.; Dzoljic, M.R., and Godschalk, M.: Effect of Clozapine on the Sleep
Pattern in the R a t .......................................................................................................
Book Reviews ..................................................................... 90,191,288,367,478,
Varia ...................................................... ........................................................... 288,
Author In d e x ...............................................................................................................
Subject Index...............................................................................................................
481
485
503
512
519
529
536
545
551
557
376
567
569