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Gene centers sweep prizes in German Bioregio competition

1997, Nature Biotechnology

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The article discusses the outcomes of the German Bioregio competition, highlighting the selection of three model regions for biotechnology: Munich, BioRegio Rheinland, and Rhein-Neckar-Dreieck. The competition aimed to enhance the status of biotechnology in Germany and attracted considerable attention, despite criticisms about its impact on actual investment. The winners received substantial funding, which reflects political support for the biotechnology sector.

• © 1997 Nature Publishing Group http://www.nature.com/naturebiotechnology ered by health insurance. For such practical reasons, the emerging "principles" are expected to endorse "viral load testing" as perhaps the best way of following the clinical progress of HIV-infected individuals and the impact on them of Pis and other therapeutic regimens, according to Mark Feinberg of OAR. Moreover, although the panel members are unlikely to prescribe any particular therapeutic regimens, they are wrestling with the idea of recommending that drug combinations-in most cases, to include Pis-be used to keep viral load below certain thresholds. For instance, one such benchmark would be to aim at keeping an individual's blood-virus levels below current limits of detectability by the most sensitive RNA amplification procedures available. The underlying goal is, if not to eradicate infection, at least to reduce viral replication so drastically that drug-resistant variants will be less likely to emerge, Feinberg notes. Jeffrey L. Fox Answers to quiz on p.7 A1: A piece of Alexander Fleming's Penicillium mold. A2: All are operating companies of Titan Phannaceuticals (S. San Francisco, CA), except for Titanic, which met a watery grave. A3: (1) Peter Goodfellow is senior vice president of biophannaceutical R&D at SmithKline Beecham (Klng of Prussia, PA); (2) C. Thomas Caskey is senior vice president Merck Research Laboratories (West Point, PA); (3) Daniel Cohen is chief scientific officer of Genset (Paris). Celebration, a town in Florida, where Eli-Lilly (Indianapolis, IN) and Disney together launched a "wonderful world" of home drug management in early 1996. A4: Gene centers sweep prizes in German Bioregio competition Following seven days of deliberation, on November 20, Karl Molitor, leader of the German Chemical Industry Employers Association and chairman of the Bioregio jury, Biotechnologie Initiativkreis named Mtinchen (Munich), BioRegio Rheinland (Cologne, Dusseldorf, Wuppertal and Aachen) and BioRegion Rhein-NeckarDreieck (Heidelberg, Ludwigshafen and Mannheim) as the three model regions for German biotechnology. All three had been strongly tipped (see Nature Biotechnology 14:1664-1665, 1996), having received special support for gene technology over the past ten years as one of four gene centers, with Berlin the only one of the four to miss out. The IO-person jury, drawn from industry, research, and trade unions and including members from outside Germany, reviewed more than 5,000 pages of proposals and interviewed representatives of all 17 regions before awarding DMS0 million (US$33 million) over 5 years to each of the model regions. In addition to the 3 winners, the jury also gave a special commendation to Jena, the smallest of the 17 regions and the home of Carl Zeiss, for its contribution to bioinstrumentation. of development Whether Jena will also receive any special treatment with regard to the allocation of the rest of the DM 200 million (US133 million) a year Germany ministry of education science, research, and technology (BMBF) budget has yet to be decided. Although the final decision largely reflects the accepted status quo in the German biotechnology sector, and some analysts are already questioning the real impact of the competition on biotechnology investment, the Bioregio competition has certainly been a political success for the BMBF. It succeeded Christopher Redhead is a freelance writer working in Cologne ( [email protected]). in generating valuable positive press coverage, presenting biotechnology as both an important part of the economy and a job creator, and dispelling some of the negative image that has plagued biotechnology in Germany in the past. There are three winners, but no losers. The biggest winner is the status of German biotechnology, says Jurgen Rtittgers, Germany's Research Minister. Despite Rtittgers' words, concern has already been expressed that the three winners may now eclipse the rest of Germany in the fight for important foreign investment and joint ventures. Particular disappointment was felt in Berlin, which as one of the four original genes centers, and following massive investment from Bonn after German reunification, has one of the most dynamic biotechnology sectors in the country. Recently rated second only to Munich for biotechnology potential by the German magazine Laborjournal, Berlin was praised by the Bioregio jury for having the highest number of biotechnology startups. "Not to have highlighted Berlin is like buying a new Mercedes and leaving it in the garage," says Hartmut Gtirbel, chairman of the Berlin/Brandenburg initiative. "We have no complaint with the jury, but the competition criteria were simply wrong. There was too much stress on the regional presence of large companies such as Bayer and BASF." Berliners may be disappointed, but they are undeterred. "We may have lost the battle in the conference room, but we will certainly win the war in the market;' declares Giirbel. This sentiment is echoed in other regions. "We are looking forward," says Wolfgang Becker, spokesperson for the Ministry of Economic Affairs in Hamburg, "The Hamburg area has a top-ranking biomedical sector. Our companies are small, innovative, and flexible and it won't be long before we too are in the spotlight:' NATURE BIOTECHNOLOGY VOLUME 15 JANUARY 1997 A5: Jan Leemans. The rest are women. A6: Home Access Express, the first home diagnostic kit for HIV, which has been available over the phone since July 1996 (1800-HIV-TESl). A7: (1) Optro is Somatogen's recombinant human hemoglobin that is in late phase II trials as blood substitute. (2) Redux is a small molecule, dexfenfluoramine, marketed by lnterneuron Phannaceutlcals (Lexington, MA) and approved by FDA in April 1996. (3) BeneFix is Genetics lnstitute's (Cambridge, MA) recombinant Factor IX for treating hemophilia 8-a biological license application for which was submitted to FDA in September 1996. (4) Synovir is a chiral thalidomide marketed by Celgene (Warren, NJ) for the treatment of severe weight loss in AIDS patients. (5) Targretin Is a retlnoid subtype receptor selective agonist from Ligand Phannaceuticals (San Diego, CA) in phase 11/111 trials for T-cell lymphoma (6) Vistide is a nucleotide analog marketed by Gilead Sciences (Foster City, CA) for the treatment of cytomegalovirus retinitis. AS: They are all brand names for recombinant erythropoietin. Amgen's Epogen, which had worldwide sales of $2.9 billion in 1995, Is marketed globally through the following licensees: Johnson & Johnson (New Brunswick, NJ) sell Procrit in the US for all indications except dialysis and diagnostics, for which Amgen markets the drug; Cilag, a subsidiary of Johnson & Johnson, markets it under the name Eprex throughout Europe; Sankyo (Tokyo, Japan) sells it under the name Espo in Japan. Also in the US, Genetics Institute (Cambridge, MA) markets Reconnin for anemia due to kidney disease. A9: (1) Cambridge Biotech Corporation (Worcester, MA) became Aquila Biophannaceuticals in October 1996; (2) AgrEvo (Berlin, Germany) was fonned by Hoechst and Schering AG in 1994; and (3) Celltech Biologics (Slough, UK) became part of the Swiss specialty chemicals group, Lonza Biologics (Basel), on June 12, 1996. A10: The 20-amino acid erythropoietin mimetic created by researchers at R.W. Johnson Research Laboratories (Raritan, NJ), Affymax (Palo Alto, CA), and Scripps Research Institute (La Jolla, CA). Wells declared in a commentary in Science (273:449-450, 1996) that the research was "enough to reinstate one's belief in Santa Claus." Christopher Redhead 15